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The urgent demand for stable electrode materials, especially for the anode, arises in the pursuit of high-energy Li-ion batteries. This research focuses on bismuth oxide (Bi2O3) and uncovers its performance through a straightforward, commercially viable synthesis route, along with the optimization of binders and electrolytes. By employing a sodium carboxymethyl cellulose binder and fluoroethylene carbonate additives, the Bi2O3 anode demonstrates significantly enhanced performance compared to prior studies. It attains an impressive initial capacity of approximately 750 mA h g−1, exhibits excellent rate capability at 1000 mA g−1 and maintains stable cycling performance over 6000 cycles.

People with mental illness tend to present low levels of physical activity and high levels of sedentary behavior. The study aims to compare these levels in mental illness patients, exploring the role of socioeconomic development and treatment setting. This cross-sectional study used accelerometers and the Simple Physical Activity Questionnaire (SIMPAQ) to assess physical activity and sedentary behavior in mental illness individuals living in 23 countries. Two-way ANOVAs were used to evaluate the interaction between socioeconomic development and the treatment settings on physical activity and sedentary behavior. A total of 884 (men = 55.3%) participants, mean age of 39.3 (SD = 12.8), were evaluated. A significant interaction between socioeconomic development and treatment settings was found in sedentary behavior (F = 5.525; p = 0.019; η2p = 0.009; small effect size). Main effects were observed on socioeconomic development (F = 43.004; p < 0.001; η2p = 0.066; medium effect size) and treatment setting (F = 23.001; p < 0.001; η2p = 0.036; small effect size) for sedentary behavior and physical activity: socioeconomic development (F = 20.888; p < 0.001; η2p = 0.033; small effect size) and treatment setting (F = 30.358; p < 0.001; η2p = 0.047; small effect size), showing that HIC patients were more active, while MIC patients were more sedentary. Moreover, despite of inpatients had presented higher levels of physical activity than outpatients, they also spent more time sitting. Socioeconomic development plays an important role in sedentary behavior in patients with mental disorders, warning the need to develop new strategies to reduce these levels in this population.

La gestión del riesgo destaca la importancia en la integración de los ejes estrategia-desempeño-riesgos, para cumplir metas y objetivos. Precisamente el objetivo de este trabajo es analizar la gestión del riesgo integrada a la estrategia en las instituciones de educación superior, a partir de los cinco componentes que plantea el informe COSO IV “Gestión del riesgo empresarial integrando estrategia y desempeño”. Se utilizaron métodos teóricos como el histórico-lógico, análisis y síntesis e inducción deducción. Los resultados ostentan un acercamiento del riesgo a las estrategias universitarias, la implementación de la gestión del riesgo enfocado a la educación superior, y las experiencias sobre la temática en estos establecimientos de varios países de la región Iberoamericana, a partir de la revisión bibliográfica realizada. Se concluye, en la implementación de la gestión del riesgo en la educación superior, se ha centrado en la fase de evaluación y establecimiento del contexto, obviándose el componente “gobierno y cultura” como elemento crítico en el establecimiento de una cultura de control, y transitan hacia el nuevo modelo.

Traumatic Brain Injuries (TBIs), including mild TBI (mTBI) and concussions, affect an estimated 69 million individuals annually with significant cognitive, physical, and psychosocial consequences. The Sport Concussion Assessment Tool 5th Edition (SCAT5) is pivotal for diagnosing these conditions but possesses inherent subjectivity. Conversely, eye-tracking systems provide objective data, capturing subtle disruptions in ocular and cognitive functions often missed by traditional measures. Yet, the concurrent use of these promising tools for neurotrauma diagnostics is relatively unexplored. This paper proposes integrating eye-tracking with SCAT5 to enhance mTBI and concussion diagnostics. We introduce a model that synergistically combines the strengths of both techniques into an ‘ocular score’, adding objectivity to SCAT5. This union promises improved clinical decision-making, impacting return-to-play, fitness-to-drive, and return-to-work judgments, providing a novel landscape in the neurotrauma scenario. However, our theoretical framework requires empirical validation. We advocate for future large-scale collaborative research databases, and exploration of eye-tracking-based diagnostic markers. Our methodology highlights the potential of this integrated approach to redefine neurotrauma management and diagnostics, addressing a critical global health concern with proven utility in high-risk settings like sports and the military.

Similar to streptavidin, the binding of biotin by avidin does not appear to be cooperative in the traditional sense of altered binding strength, though it appears to be cooperative in terms of ligand induced structural communication across subunits in the protein as previously shown for streptavidin. In this work we provide data from intrinsic tryptophan fluorescence as evidence of a cooperative structural change. The technique involves examination of the changes in fluorescence emission corresponding to the various tryptophan populations accompanying avidin-biotin binding. We note that the 335 nm emission population (i.e. more hydrophobic local environment) saturates prior to full ligation and the saturation of the 350 nm emission population commonly used in standard binding activity assays. We also note that total integrated fluorescence emission and peak height during the titration of ligand into streptavidin also reach saturation prior to the 4:1 stoichiometric end point. Unique to avidin and distinct from the behavior of streptavidin described in our prior work, the wavelength of maximum emission and full width at half maximum (FWHM) data do not saturate prior to the 4:1 stoichiometric end point. Avidin also exhibited larger FWHM for both apo and holo forms suggesting greater heterogeneity in local tryptophan environments, as compared to streptavidin. Taken together, the data suggests that the binding of the first 3 biotins effect greater structural changes in the protein than the final ligand in a similar way for avidin and streptavidin.

While hierarchical linear modeling is often used in social science research, the assumption of normally distributed residuals at the individual and cluster levels can be violated in empirical data. Previous studies have focused on the effects of nonnormality at either lower or higher level(s) separately. However, the violation of the normality assumption simultaneously across all levels could bias parameter estimates in unforeseen ways. This article aims to raise awareness of the drawbacks associated with compounded nonnormality residuals across levels when the number of clusters range from small to large. The effects of the breach of the normality assumption at both individual and cluster levels were explored. A simulation study was conducted to evaluate the relative bias and the root mean square of the model parameter estimates by manipulating the normality of the data. The results indicate that nonnormal residuals have a larger impact on the random effects than fixed effects, especially when the number of clusters and cluster size are small. In addition, for a simple random-effects structure, the use of restricted maximum likelihood estimation is recommended to improve parameter estimates when compounded residuals across levels show moderate nonnormality, with a combination of small number of clusters and a large cluster size.

Filtration has emerged as a critical technology to reduce waterborne diseases caused by poor water quality. Filtration technology presents key challenges, such as membrane selectivity, permeability and biofouling. Nanomaterials can offer solutions to these challenges by varying the membranes' mechanical and bactericidal properties. This research uses nanodiamond particles with facile surface functionality and biocompatibility properties that are added to membranes used for filtration treatments. Scanning and transmission electron microscopy (SEM and TEM) and Fourier transform infrared spectroscopy (FTIR) were performed to study the membrane surface. FTIR spectra confirms an increase in oxygen functional groups onto the ultradispersed diamond's (UDD) surface following acid treatment. SEM images show particle deagglomeration of functionalized UDD at the membrane surface. Tensile strength tests were done to measure the UDD mechanical properties and Coliscan membrane filtration characterization was performed to determine the filter effectiveness. Polyether sulfone (PES) and polyvinylidene (PVDF) membranes expressed a change in their yield point when UDD was incorporated into the porous matrix. A significant microorganism reduction was obtained and confirmed using t-test analysis at a 95% level of confidence. UDD-embedded membranes exhibit a significant bactericidal reduction compared to commercial membranes suggesting these membranes have the potential to enhance current membrane filtration systems. HIGHLIGHTS Carbon nanoparticles, embedded in organic membranes, are used for microbial removal in filtration treatment.; The removal of pathogenic microbes by these organic membranes are enhanced by the incorporation of carbon nanoparticles on their surface, leading to enhanced water filtration treatment.; The mechanical properties of the organic membranes embedded with carbon nanoparticles are modified, creating a membrane with higher or lower yield point depending on the membrane's symmetrical or asymmetrical structure.; The development of these organic/carbon nanoparticle membranes has the potential to enhance their useful lifetime and reduce microbial biofouling, thereby increasing drinking water quality and quantity while reducing operational costs for filtration treatment.;

Abstract Human Muscular Manipulability is a metric that measures the comfort of an specific pose and it can be used for a variety of applications related to healthcare. For this reason, we introduce KIMHu: a Kinematic, Imaging and electroMyography dataset for Human muscular manipulability index prediction. The dataset is comprised of images, depth maps, skeleton tracking data, electromyography recordings and 3 different Human Muscular Manipulability indexes of 20 participants performing different physical exercises with their arm. The methodology followed to acquire and process the data is also presented for future replication. A specific analysis framework for Human Muscular Manipulability is proposed in order to provide benchmarking tools based on this dataset.

Abstract In some modern communication systems, as it is the case of WiMAX, it has been decided to implement Demand Assignment Multiple Access (DAMA) solutions. End-users request transmission opportunities before accessing the system, which provides an efficient way to share system resources. In this paper, we briefly review the PHY and MAC layers of an OFDMA-based WiMAX system, and we propose to use a Network Utility Maximization (NUM) framework to formulate the DAMA strategy foreseen in the uplink of IEEE 802.16. Utility functions are chosen to achieve fair solutions attaining different degrees of fairness and to further support the QoS requirements of the services in the system. Moreover, since the standard allocates resources in a terminal basis but each terminal may support several services, we develop a new decomposition technique, the coupled-decompositions method, that obtains the optimal service flow allocation with a small number of iterations (the improvement is significant when compared to other known solutions). Furthermore, since the PHY layer in mobile WiMAX has the means to adapt the transport capacities of the links between the Base Station (BS) and the Subscriber Stations (SSs), the proposed PHY-MAC cross-layer design uses this extra degree of freedom in order to enhance the network utility.

We analyze the existing trade-offs in terms of system performance versus fairness of a cooperative system based on opportunistic relay selection (ORS) and with outdated channel state information (CSI). In particular, system performance is analytically evaluated in terms of outage probability, and the fairness behavior is assessed based on the power consumption at the different relays. In order to improve the fairness behavior of ORS while keeping the selection diversity gain, we propose a relay selection mechanism where the relay with the highest normalized signal-to-noise ratio (SNR) is selected for relaying the source's information. The proposed strategy is compared with existing relay selection strategies by adopting a novel graphical representation inspired by expected profit versus risk plots used in modern portfolio theory. As shown in the paper, this strategy allows operating the system in more favorable points of the outage versus fairness region.

[This corrects the article DOI: 10.3389/fnmol.2020.00013.].

Purpose: The purpose of this study is to present Prof-teaching, an Englishmedium instruction (EMI) lecturer training program at the University of Alicante (UA) and to determine if it meets the needs of the institution's current and prospective EMI lecturers. Design/methodology/approach: In this case study, the EMI lecturer professional development program is described along with the surveys and course evaluations carried out to assess its effectiveness. The description focuses on the UA context, the key factors that promoted Prof-teaching, as well as the objectives and components of its three modules. Course participants' teaching experiences, needs and challenges are compared together with their course evaluations, which consisted of quality assurance questionnaires for each module. Findings and originality/value: The findings not only provide evidence of the program's benefits, but also highlight the importance of collaborative efforts among diverse university units to implement EMI training initiatives, as well as to conduct periodic needs analysis and quality evaluations. An interesting result was that experienced EMI lecturers claimed that pedagogical training was more important than developing linguistic competence. It is recommended that programs provide lecturers with support technology and mentoring schemes with previously trained EMI content lecturers who already have experience teaching their subjects in English.

This quasi-experimental study analyses the effects of an awareness intervention programme with five different branches designed to improve the attitudes of physical education (PE) students towards the inclusion of classmates with disabilities. The contact (yes/no) and its frequency (×1 vs. ×3) with para-athletes, the duration of the programme (1 vs. 6/7 sessions), and the provision of teaching strategies and materials (yes/no) were manipulated. The study involved 603 students aged 14-19 from five public educational centres in southern Spain. Attitudes were assessed pre- and post-intervention with the Spanish version of the Children's Attitude towards Integrated Physical Education (general and specific subscales) and the Scale of Attitudes towards Students with Disabilities in PE. The three groups having contact with para-athletes during the interventions improved in the three attitude variables (p < 0.05; -0.20 < d < -0.24). Pairwise comparisons of the improvement ratios also revealed several positive effects of the intervention duration and provision of teaching strategies (p < 0.05; -0.07 < d < 0.18). These findings could assist PE teachers in educating students to improve their knowledge and attitudes towards people with disabilities, having different strategies and resources to conduct awareness interventions based on para-sports in their regular PE classes.

Obstructive sleep apnea (OSA) is quite prevalent during pregnancy and is associated with adverse perinatal outcomes, but its potential influence on fetal development remains unclear. This study investigated maternal OSA impact on the fetus by analyzing gene expression profiles in whole cord blood (WCB). Ten women in the third trimester of pregnancy were included, five OSA and five non-OSA cases. WCB RNA expression was analyzed by microarray technology to identify differentially expressed genes (DEGs) under OSA conditions. After data normalization, 3238 genes showed significant differential expression under OSA conditions, with 2690 upregulated genes and 548 downregulated genes. Functional enrichment was conducted using gene set enrichment analysis (GSEA) applied to Gene Ontology annotations. Key biological processes involved in OSA were identified, including response to oxidative stress and hypoxia, apoptosis, insulin response and secretion, and placental development. Moreover, DEGs were confirmed through qPCR analyses in additional WCB samples (7 with OSA and 13 without OSA). This highlighted differential expression of several genes in OSA (EGR1, PFN1 and PRKAR1A), with distinct gene expression profiles observed during rapid eye movement (REM)-OSA in pregnancy (PFN1, UBA52, EGR1, STX4, MYC, JUNB, and MAPKAP). These findings suggest that OSA, particularly during REM sleep, may negatively impact various biological processes during fetal development.

Oxidative stress forms part of the molecular basis contributing to the development and manifestation of myopia, a refractive error with associated pathology that is increasingly prevalent worldwide and that subsequently leads to an upsurge in degenerative visual impairment due to conditions that are especially associated with high myopia. The purpose of our study was to examine the interrelation of potential oxidative-stress-related metabolites found in the aqueous humor of high-myopic, low-myopic, and non-myopic patients within a clinical study. We conducted a cross-sectional study, selecting two sets of patients undergoing cataract surgery. The first set, which was used to analyze metabolites through an NMR assay, comprised 116 patients. A total of 59 metabolites were assigned and quantified. The PLS-DA score plot clearly showed a separation with minimal overlap between the HM and control samples. The PLS-DA model allowed us to determine 31 major metabolite differences in the aqueous humor of the study groups. Complementary statistical analysis of the data allowed us to determine six metabolites that presented significant differences among the experimental groups (p < 005). A significant number of these metabolites were discovered to have a direct or indirect connection to oxidative stress linked with conditions of myopic eyes. Notably, we identified metabolites associated with bioenergetic pathways and metabolites that have undergone methylation, along with choline and its derivatives. The second set consisted of 73 patients who underwent a glutathione assay. Here, we showed significant variations in both reduced and oxidized glutathione in aqueous humor among all patient groups (p < 0.01) for the first time. Axial length, refractive status, and complete ophthalmologic examination were also recorded, and interrelations among metabolic and clinical parameters were evaluated.

The soil mantle of the tropical karst landscapes of southern Mexico was a key resource for ancient Maya agriculture and experienced deep transformation due to long-term human impacts under changing environmental conditions. We conducted a comparative analysis of three compound soil toposequences in mountainous (Sierra de Chiapas/Middle Usumacinta Valley, Busiljá, and Chinikihá archaeological sites) and platform (NE Yucatán Peninsula, Yalahau region) karst landscapes to reconstruct general tendencies and regional variations in pedodiversity development and soil–human interactions since the Early Preclassic Period. Toposequence characterization is based on macro- and micromorphological observations, accompanied by a suite of laboratory data. Calcareous upland geoforms of all toposequences have similar soil combinations consisting of shallow Rendzina and deep red clayey Terra Rossa types of profiles. We argue that Rendzinas, now dominant in the upland soil cover, in most cases, are not a product of incipient pedogenesis on limestone; they have developed from the residues of Terra Rossa soils after their advanced erosion. Pedosediments generated by ancient soil erosion have been found in the piedmont and depression positions in the mountainous landscapes of Chiapas, as a result of lateral downslope soil removal, and in the subsurface karstic cavities in the platform of NE Yucatán, indicating vertical “soil piping.” The soils of the lowland domains show contrasting differences between the toposequences: gleyic clay–rich soils and humic alluvial soils prevail in Chinikihá and Busiljá, whereas hydromorphic carbonate soils have formed in Yalahau karstic depressions. These differences in the lowland soil properties led to divergent ancient Maya land use strategies; in Chinikihá and Busiljá, the major agricultural domain was developed in the lowlands, implying largescale artificial drainage. On the contrary, in Yalahau, mostly upland Rendzinas were cultivated, implying “precision agriculture” and “container gardening.”

Abstract This article presents a case for more rigorous application of complexity science in our efforts to evaluate activity that seeks to bring about transformative change. It builds on the work that is already going on in the evaluation community. Three constructs from complexity science are employed – sensitive dependence, emergence, and social attractors. The paper argues that if–then logic is recommended for small-scale change within transformation efforts, but that to evaluate transformation writ large, data from if–then evaluation must be embedded in, and interpreted in terms of, complex behavior. Methodologies for evaluating within this framework are presented. The argument is linked to a definition of transformation that is multidimensional, non-linear, and measurable. The paper is built around a generic model of transformational change and shows how that model can be customized for specific transformation scenarios. It also shows how evaluation with respect to complexity can be accomplished with methodologies that are well known and well-practiced in the evaluation community.

Assistant nurses caring for older adults with immigrant backgrounds are on the front lines of a practical, theoretical, and policy battlefield. They need to implement culturally sensitive care provision while not overstating the importance of culture, thereby, contributing to a negative picture of older immigrants as especially problematic. One proposed way to strike such a balance is the welfare theory of health (WTH). In this article, we let assistant nurses apply the WTH to a series of questions in four different vignettes representing the life stories of older persons who characterize typical dilemmas described by the theory. The results show that, through the lens of the WTH, assistant nurses looked for individual care preferences rather than stereotypical ideas about cultural characteristics. Further, the assistant nurses expressed a desire to get to know the persons more deeply to better interpret and understand their individual preferences. Thus, the theoretical framework is useful not only for exposing vulnerabilities to which some older adults with immigrant backgrounds may be exposed, but also for finding ways to mitigate the vulnerability by illuminating vital life goals and using them as a framework to organize care. This approach allows for mitigating the gap between the vital life goals and available resources to achieve a holistic state of health.

La traducción fue una de las actividades culturales que animó el genio artístico de Juan del Encina y una de las prácticas textuales, asentadas en la lectio, de la que dejó constancia en su Cancionero. Así, en este trabajo se analizan los comentarios que el propio autor disemina en su opus magnum en relación con el arte de la traducción y se reconstruye el proceso de formación en gramática que habría podido seguir. Teniéndose en cuenta que la mayoría de autores del periodo que se ejercitaron en la práctica traductora repiten, sistemáticamente, hábitos y procedimientos que provienen del ámbito académico. Todo ello, a la luz del magisterio ejercido por Nebrija en el Estudio salmantino. Tales usos, en dicho trabajo, se van ilustrando a través de casos localizados tanto en el prólogo de la Traslación de las Bucólicas como en las traducciones de los himnos bíblicos de la sección de poesía devota del Cancionero. En concreto, y a modo de ejemplo, en la del Miserere. Estas últimas han sido menos abordadas, pero evidencian, de igual manera, la importancia de dicha actividad en el proyecto creativo de Encina y su coherencia con el resto de las facetas artísticas que cultivó a lo largo de su trayectoria, en especial con la poética.

Ultrastructural descriptions of the inner ear of highly sound-dependent mammalian species are lacking and needed to gain a better understanding of the hearing sense. Here, we present the first morphometric descriptions of the sensory cells of the inner ear in the harbor seal (Phoca vitulina), a mammal with broadly sensitive amphibious hearing. Scanning electron micrographs of the apical surface of the outer hair cells (OHCs) and inner hair cells (IHCs) within the organ of Corti were obtained from five individuals and analyzed by linear and geometric morphometrics. Measurements were taken at regular locations along the cochlea. The spiral shape of the seal cochlea contained two and a half turns. The organ of Corti had an average length of 27.7 mm with 12,628 OHCs (12,400-12,900). Six linear morphometric parameters showed significant patterns of change associated with their location within the cochlear spiral. Likewise, these trends were similarly expressed in cell configuration (cell blocks with 57 landmarks in 12 representative cells) revealed by geometric morphometry. Cell configuration varied predictably with position in the cochlea according to clustering analyses and Procrustes ANOVA (F= 25.936, p

Summary: Background: COVID-19 in paediatric ages could result in hospitalizations and death. In addition, excluding children from vaccination could turn them into reservoirs of the SARS-COV-2. Safe and effective COVID-19 vaccines are urgently needed for large-scale paediatric vaccination. ISMAELILLO study aimed to evaluate safety and immunogenicity of two strengths of a new recombinant receptor-binding domain (RBD) protein vaccine (Abdala) in paediatric population. Methods: A double-blinded, multicentre, randomised, phase 1/2 clinical trial was conducted in nine polyclinics in the province of Camagüey, Cuba. Healthy children and adolescents were stratified according to age (3–11 years old, or 12–18 years old) and they were randomly assigned (1:1; block size four) in two dosage level groups of vaccine to receive three intramuscular doses of 25 μg or 50 μg of RBD, 14 days apart. Main safety endpoint was analyzed as the percentage of serious adverse reactions during vaccination up to 28 days after the third dose (Day 56) in participants who received at least one dose vaccination. The primary immunogenicity endpoint assessed was seroconversion rate of anti-RBD IgG antibody at day 56. The immunogenicity outcomes were assessed in the per-protocol population. This trial is registered with Cuban Public Registry of Clinical Trials, RPCEC00000381. Findings: Between July 15, 2021, and August 16, 2021, 644 paediatric subjects were screened, of whom 592 were enrolled after verifying that they met the selection criteria: firstly 88 were included in Phase 1 of the study and 504 who completed Phase 2. The vaccine was well tolerated. Injection site pain was the most frequently reported local event (143 [8·4%] of 1707 total doses applied), taking place in 66/851 (7·8%) in the 25 μg group and in 77/856 (9·0%) in the 50 μg. The most common systemic adverse event (AE) was headache: 23/851 (2·7%) in the 25 μg group and 19/856 (2·2%) in the 50 μg. Reactogenicity was mild or moderate in severity, represented in 75% of cases by local symptoms, completely resolved in the first 24–48 h. Twenty-eight days after the third dose, seroconversion anti-RBD IgG were observed in 98·2% of the children and adolescents (231/234) for the 50 μg group and 98·7% (224/228) for the 25 μg group without differences between both strength. The specific IgG antibody geometric mean titres (GMT) showed higher titres between participants who received Abdala 50 μg (231·3; 95% CI 222·6–240·4) compared to those who received 25 μg (126·7; 95% CI 121·9–131·7). The mean ACE2 inhibition %, were 59·4% for 25 μg, and for 50 μg, 72·9% (p