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Your search keyword '"Miyagawa, Kazuya"' showing total 629 results
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629 results on '"Miyagawa, Kazuya"'

201. Abstract 596: Increased Migration of Neutrophils Across Endothelial Cells from Patients with Pulmonary Arterial Hypertension is Related to Reduced Platelet Endothelial Cell Adhesion Molecule -1 and is Prevented by the Neutrophil Elastase Inhibitor Elafin

Author

Taylor, Shalina, primary, Moonen, Jan-Renier, additional, Miyagawa, Kazuya, additional, Gu, Mingxia, additional, Sa, Silin, additional, Hennigs, Jan, additional, Wang, Lingli, additional, and Rabinovitch, Marlene, additional

Published
2016
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202. Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice.

Author

Tsuji, Minoru, Arai, Iwao, Miyagawa, Kazuya, Miyagishi, Hiroko, Saito, Atsumi, Takeda, Kotaro, Takeda, Hiroshi, Akiyama, Nobutake, and Saito, Saburo

Subjects
CELL receptors, ANALGESICS, ANIMAL experimentation, BIOLOGICAL models, ITCHING, MICE, MORPHINE, NARCOTICS, PAIN, CELL physiology
Abstract

Background: Morphine is an effective analgesic for the treatment of severe pain, but it can cause itching in patients. In the present study, we examined the possible involvement of interleukin-31 (IL-31) receptor A (IL-31RA) on the morphine-induced itching and antinociception in mice.Methods: Long-lasting scratching (LLS) and short-lasting scratching (SLS) were estimated as an indicator of itching and nonspecific behaviour, respectively, and antinociception was evaluated using a hot-plate test in mice.Results: Morphine (5 mg/kg, s.c.) induced multiple episodes of SLS, few episodes of LLS, and antinociception in naive mice, with a close correlation observed between SLS or LLS counts and antinociception. In IL-31RA-deficient (IL-31RA-/- ) mice, morphine (5 mg/kg, s.c.)-induced LLS but not SLS was completely abolished, while antinociception was partially suppressed with 2.5 and 5 mg/kg but not 10 mg/kg, s.c. of morphine administration. Interestingly, intracerebroventricular (i.c.v.) administration of morphine (10 μg/mouse) significantly increased SLS but not LLS, and this effect was higher in IL-31RA-/- mice than that in wild-type mice. Furthermore, following i.c.v. administration of morphine (10 μg/mouse), the antinociceptive effect was also significantly higher in IL-31RA-/- mice than that in wild-type mice.Conclusion: Taken together, the present findings suggest that IL-31RA may play a significant role, perhaps in the sensory neurons and/or spinal cord rather than in the brain, in the modulation of morphine-induced itching and antinociception.Significance: Here, we demonstrate a possible common mediator of itching and antinociception of morphine, interleukin-31 (IL-31) receptor A (IL-31RA). IL-31RA may be a noteworthy target for considering the novel mechanism of itch and pain signalling affected by morphine. [ABSTRACT FROM AUTHOR]

Published
2019
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208. Abstract 17231: Contact-Mediated Interaction Between Pulmonary Artery Endothelial and Smooth Muscle Cells Promotes a BMPR2-β-catenin-Notch1 Signal Causing Hyperpolarization of Endothelial Mitochondria and a Stalk Cell-like Phenotype

Author

Miyagawa, Kazuya, primary, Li, Caiyun G, additional, Hennigs, Jan K, additional, Taylor, Shalina, additional, Moonen, Jan-Renier, additional, Sa, Silin, additional, Wang, Lingli, additional, Cao, Aiqin, additional, and Rabinovitch, Marlene, additional

Published
2015
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220. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice.

Author

Miyagawa, Kazuya, Tsuji, Minoru, Fujimori, Kanji, Saito, Yasuho, Takeda, Hiroshi, Miyagawa, Kazuya, Tsuji, Minoru, Fujimori, Kanji, Saito, Yasuho, and Takeda, Hiroshi

Abstract

Most pregnant women are at risk of showing some emotional abnormality, since some biological functions such as hormonal systems may dramatically change in pregnancy. Some of them may be exposed to strong stress as hesitation of positive drug therapies because of worries regarding adverse effects on the embryo. A growing body of evidence suggests that prenatal stress increases the vulnerability to neuropsychiatric disorders, including depression and anxiety. However, the mechanisms involved are still unknown. To clarify the influence of exposure to prenatal stress on emotional development, we examined behavioral responses in offspring exposed to weak- or strong-prenatal restraint stress. We found that offspring that had been exposed to strong stress displayed anxiety-like behavior as determined by the elevated plus-maze test. It has been widely accepted that central serotonin (5-hydroxytryptamine; 5-HT) neurons play a critical role in emotional behaviors. Immunohistochemical studies showed that exposure to strong-prenatal restraint stress increased the expression of 5-HT-positive cells in the dorsal raphe nuclei in mice. Moreover, under these conditions, tryptophan hydroxylase-like immunoreactivities were also dramatically increased. In contrast, these behavioral and neurochemical abnormalities were not observed in offspring that had been exposed to weak-prenatal restraint stress. These findings indicate that exposure to excessive prenatal stress induces anxiety-like behavior together with disruption of the development of 5-HT neurons in mice., source:http://www.ncbi.nlm.nih.gov/pubmed?term=21320553

Published
2012

233. Subsequent shunt closure after targeted medical therapy can be an effective strategy for secundum atrial septal defect with severe pulmonary arterial hypertension: two case reports

Author

Taniguchi, Yu, primary, Emoto, Noriaki, additional, Miyagawa, Kazuya, additional, Nakayama, Kazuhiko, additional, Kinutani, Hiroto, additional, Tanaka, Hidekazu, additional, Shinke, Toshiro, additional, Okada, Kenji, additional, Okita, Yutaka, additional, and Hirata, Ken-ich, additional

Published
2013
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241. Upregulation of Human Endogenous Retrovirus-K Is Linked to Immunity and Inflammation in Pulmonary Arterial Hypertension

Author

Saito, Toshie, Miyagawa, Kazuya, Chen, Shih-Yu, Tamosiuniene, Rasa, Wang, Lingli, Sharpe, Orr, Samayoa, Erik, Harada, Daisuke, Moonen, Jan-Renier A.J., Cao, Aiqin, Chen, Pin-I, Hennigs, Jan K., Gu, Mingxia, Li, Caiyun G., Leib, Ryan D., Li, Dan, Adams, Christopher M., del Rosario, Patricia A., Bill, Matthew, Haddad, Francois, Montoya, Jose G., Robinson, William H., Fantl, Wendy J., Nolan, Garry P., Zamanian, Roham T., Nicolls, Mark R., Chiu, Charles Y., Ariza, Maria E., and Rabinovitch, Marlene

Abstract

Supplemental Digital Content is available in the text.

Published
2017
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245. Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

Author

Widyantoro, Bambang, primary, Emoto, Noriaki, additional, Nakayama, Kazuhiko, additional, Anggrahini, Dyah W., additional, Adiarto, Suko, additional, Iwasa, Naoko, additional, Yagi, Keiko, additional, Miyagawa, Kazuya, additional, Rikitake, Yoshiyuki, additional, Suzuki, Takashi, additional, Kisanuki, Yaz Y., additional, Yanagisawa, Masashi, additional, and Hirata, Ken-ichi, additional

Published
2010
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