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202. Sub-target effect in film analysis using TEA CO2 laser-induced plasma

Author

Nasrullah Idris, Kenichiro Tsuyuki, Tjung Jie Lie, Yong-Inn Lee, Koo Hendrik Kurniawan, Miura Satoru, and Kiichiro Kagawa

Subjects
Analytical chemistry, General Physics and Astronomy, chemistry.chemical_element, Laser, Copper, Emission intensity, law.invention, chemistry, law, Impurity, General Materials Science, Emission spectrum, Thin film, Electrolytic process, Carbon
Abstract

A TEA CO 2 laser beam (500 mJ, 200 ns) was focused on film samples, under low pressure surrounding gas at around 1 Torr. It has been found that to generate the laser plasma for the sample of oil or powder, the sample should be attached in the form of thin film on the surface of a metal, such as copper plate, which acts as a sub-target. The plasma has favorable characteristics for spectrochemical analysis due to its low background and sharp line spectrum, and hence an optical multichannel analyzer (OMA) without gated function can be used for spectrum acquisition. Using the sub-target effect we have performed for analyses on water molecular layer and water impurities, where the water was condensed by heating process or electrolysis process on the sub-target so that impurities in the water were attached to the metal surface. It should be emphasized that in this case the sub-target itself has never been ablated and no any damaged on its surface. Another application of the sub-target effect is used for the analysis of oil contamination in soils. We have succeeded to detect clearly the emission line of C I 247.9 nm from the carbon as a major constituent of the oil. To derive the carbon emission intensity coming only from oil, compensation was made to cancel the contribution from other organic species using the emission of Ca, which inherently contains in other organic species in soil. As result, a good linear relationship between carbon emission intensity and oil concentration was obtained.

Published
2007

204. Afatinib for the Treatment of NSCLC Harboring Uncommon EGFRMutations: A Database of 693 Cases

Author

Yang, James Chih-Hsin, Schuler, Martin, Popat, Sanjay, Miura, Satoru, Heeke, Simon, Park, Keunchil, Märten, Angela, and Kim, Edward S.

Abstract

Limited clinical data are available regarding the efficacy of EGFR tyrosine kinase inhibitors (EGFR TKIs) in patients with NSCLC harboring uncommon EGFRmutations. This pooled analysis assessed the activity of afatinib in 693 patients with tumors harboring uncommon EGFRmutations treated in randomized clinical trials, compassionate-use and expanded-access programs, phase IIIb trials, noninterventional trials, and case series or studies.

Published
2020
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205. Influence of Polymer Dispersant on the Granulation of Raw Materials for Sintering Process

Author

Miura Satoru, Katsuyuki Kono, Jun Okazaki, Nakano Masanori, and Okada Tsutomu

Subjects
chemistry.chemical_classification, Materials science, Metals and Alloys, Sintering, Polymer, Raw material, Condensed Matter Physics, Dispersant, Granulation, chemistry, Chemical engineering, Scientific method, Materials Chemistry, Physical and Theoretical Chemistry, Composite material, Iron ore sintering
Published
2006

206. Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer.

Author

Naito, Tateaki, Mitsunaga, Shuichi, Miura, Satoru, Tatematsu, Noriatsu, Inano, Toshimi, Mouri, Takako, Tsuji, Tetsuya, Higashiguchi, Takashi, Inui, Akio, Okayama, Taro, Yamaguchi, Teiko, Morikawa, Ayumu, Mori, Naoharu, Takahashi, Toshiaki, Strasser, Florian, Omae, Katsuhiro, Mori, Keita, and Takayama, Koichi

Subjects
DISEASES in older people, PANCREATIC cancer, NON-small-cell lung carcinoma, EXERCISE, DIET in disease
Abstract

Background: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. Methods: This was a multicentre prospective single‐arm study. We recruited 30 of 46 screened patients aged ≥70 years scheduled to receive first‐line chemotherapy for newly diagnosed, advanced pancreatic, or non‐small‐cell lung cancer. Physical activity was measured using pedometers/accelerometer (Lifecorder®, Suzuken Co., Ltd., Japan). An 8 week educational intervention comprised three exercise and three nutritional sessions. The exercise interventions combined home‐based low‐intensity resistance training and counselling to promote physical activity. Nutritional interventions included standard nutritional counselling and instruction on how to manage symptoms that interfere with patient's appetite and oral intake. Supplements rich in branched‐chain amino acids (Inner Power®, Otsuka Pharmaceutical Co., Ltd., Japan) were provided. The primary endpoint of the study was feasibility, which was defined as the proportion of patients attending ≥4 of six sessions. Secondary endpoints included compliance and safety. Results: The median patient age was 75 years (range, 70–84). Twelve patients (40%) were cachectic at baseline. Twenty‐nine patients attended ≥4 of the six planned sessions (96.7%, 95% confidence interval, 83.3 to 99.4). One patient dropped out due to deteriorating health status. The median proportion of days of compliance with supplement consumption and exercise performance were 99% and 91%, respectively. Adverse events possibly related to the NEXTAC programme were observed in five patients and included muscle pain (Grade 1 in two patients), arthralgia (Grade 1 in one patient), dyspnoea on exertion (Grade 1 in one patient), and plantar aponeurositis (Grade 1 in one patient). Conclusions: The early induction of multimodal interventions showed excellent compliance and safety in elderly patients with newly diagnosed pancreatic and non‐small‐cell lung cancer receiving concurrent chemotherapy. We are now conducting a randomized phase II study to measure the impact of these interventions on functional prognosis. [ABSTRACT FROM AUTHOR]

Published
2019
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207. Real-World Pharmacokinetics, Effectiveness, and Safety of Atezolizumab in Patients with Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer: An Exploratory Study of J-TAIL

Author

Yagishita, Shigehiro, Goto, Yasushi, Nishio, Makoto, Akamatsu, Hiroaki, Hayashi, Hidetoshi, Miura, Satoru, Tamada, Koji, Kagamu, Hiroshi, Hamada, Akinobu, Ohuchi, Mayu, Gemma, Akihiko, Yoshino, Ichiro, Misumi, Toshihiro, Hata, Akito, Hara, Satoshi, Kijima, Takashi, Masaki, Fujita, Iwasawa, Shunichiro, Nakagawa, Shintaro, Tatsuno, Masahiro, and Mitsudomi, Tetsuya

Abstract

This study validated real-world pharmacokinetic (PK) data using an established population PK (PopPK) model for atezolizumab in Japanese patients with NSCLC and explored the relationship between PK parameters, effectiveness, and adverse events (AEs) for the 1200 mg Q3W regimen.

Published
2024
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208. Characteristics of initial deposition and behavior of radiocesium in forest ecosystems of different locations and species affected by the Fukushima Daiichi Nuclear Power Plant accident

Author

Komatsu, Masabumi, primary, Kaneko, Shinji, additional, Ohashi, Shinta, additional, Kuroda, Katsushi, additional, Sano, Tetsuya, additional, Ikeda, Shigeto, additional, Saito, Satoshi, additional, Kiyono, Yoshiyuki, additional, Tonosaki, Mario, additional, Miura, Satoru, additional, Akama, Akio, additional, Kajimoto, Takuya, additional, and Takahashi, Masamichi, additional

Published
2016
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210. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors

Author

Sato, Ko, primary, Watanabe, Satoshi, additional, Ohtsubo, Aya, additional, Shoji, Satoshi, additional, Ishikawa, Daisuke, additional, Tanaka, Tomohiro, additional, Nozaki, Koichiro, additional, Kondo, Rie, additional, Okajima, Masaaki, additional, Miura, Satoru, additional, Tanaka, Junta, additional, Sakagami, Takuro, additional, Koya, Toshiyuki, additional, Kagamu, Hiroshi, additional, Yoshizawa, Hirohisa, additional, and Narita, Ichiei, additional

Published
2016
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212. ゲフィチニブによる腸管気腫症発症後に安全にエルロチニブを投与しえた肺腺癌の1例

Author

大坪, 亜矢, 渡部, 聡, 田中, 知宏, 石川, 大輔, 近藤, 利恵, 大嶋, 康義, 坂上, 拓郎, 野嵜, 幸一郎, 岡島, 正明, 三浦, 理, 田中, 純太, 各務, 博, 吉澤, 弘久, 成田, 一衛, 峠, 弘治, 丸山, 智宏, 若井, 俊文, Ohtsubo, Aya, Watanabe, Satoshi, Tanaka, Tomohiro, Ishikawa, Daisuke, Kondo, Rie, Ohshima, Yasuyoshi, Sakagami, Takuro, Nozaki, Koichiro, Okajima, Masaaki, Miura, Satoru, Tanaka, Junta, Kagamu, Hiroshi, Yoshizawa, Hirohisa, Narita, Ichiei, Toge, Koji, Maruyama, Tomohiro, Wakai, Toshifumi, 大坪, 亜矢, 渡部, 聡, 田中, 知宏, 石川, 大輔, 近藤, 利恵, 大嶋, 康義, 坂上, 拓郎, 野嵜, 幸一郎, 岡島, 正明, 三浦, 理, 田中, 純太, 各務, 博, 吉澤, 弘久, 成田, 一衛, 峠, 弘治, 丸山, 智宏, 若井, 俊文, Ohtsubo, Aya, Watanabe, Satoshi, Tanaka, Tomohiro, Ishikawa, Daisuke, Kondo, Rie, Ohshima, Yasuyoshi, Sakagami, Takuro, Nozaki, Koichiro, Okajima, Masaaki, Miura, Satoru, Tanaka, Junta, Kagamu, Hiroshi, Yoshizawa, Hirohisa, Narita, Ichiei, Toge, Koji, Maruyama, Tomohiro, and Wakai, Toshifumi

Abstract

症例は71歳, 男性. X-3年9月13日から左肺腺癌に対しゲフィチニブの内服治療を開始された. X年2月21日に腹痛, 嘔吐を主訴に当科を受診. 腹部造影CTで小腸腸管壁内ガス像および腹腔内遊離ガス像を指摘された. ゲフィチニブによる腸管気腫症と診断され, 内服を中止し保存的治療で軽快した. ゲフィチニブ中止後, 原病の増悪を認めたためX年4月15日からエルロチニブの内服を開始した. エルロチニブ内服開始後も腸管気腫症の再燃はなく, 腫瘍の縮小を認めた. ゲフィチニブによる腸管気腫症は過去2例の報告のみである. 今回我々は, ゲフィチニブにて腸管気腫症を発症し, エルロチニブにて安全に治療を再開可能であった症例を経験した. 極めて稀な症例であり, 文献的考察を含め報告した.

Published
2015

217. Docetaxel Plus Ramucirumab With Primary Prophylactic Pegylated Granulocyte-Colony Stimulating Factor Support for Elderly Patients With Advanced NSCLC: A Multicenter Prospective Single Arm Phase 2 Trial: DRAGON Study (WJOG9416L)

Author

Tachihara, Motoko, Hata, Akito, Tokito, Takaaki, Hara, Satoshi, Okada, Hideaki, Miura, Satoru, Sato, Yuki, Tabata, Eriko, Watanabe, Hiroshi, Takayama, Yusuke, Toyozawa, Ryo, Ota, Keiichi, Wakuda, Kazushige, Nakamura, Atsushi, Shimokawa, Mototsugu, Yamamoto, Nobuyuki, and Nakagawa, Kazuhiko

Abstract

Docetaxel plus ramucirumab could be a promising treatment for chemo-naive elderly patients with NSCLC, but high incidence of febrile neutropenia (FN) is a critical concern. We thus adopted a routine primary prophylactic pegylated-granulocyte-colony stimulating factor (PEG-G-CSF) to reduce FN and maximize the efficacy of docetaxel plus ramucirumab in elderly patients.

Published
2023
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218. Abstract 3153: Critical roles of chemo-resistant effector and regulatory T cells in cancer immunotherapy during hemostatic proliferation

Author

Sato, Ko, primary, Watanabe, Satoshi, additional, Saida, Yu, additional, Tanaka, Tomohiro, additional, Baba, Junko, additional, Ohtsubo, Aya, additional, Shoji, Satoshi, additional, Ishikawa, Daisuke, additional, Kondo, Rie, additional, Okajima, Masaaki, additional, Miura, Satoru, additional, Tanaka, Junta, additional, Kagamu, Hiroshi, additional, Yoshizawa, Hirohisa, additional, and Narita, Ichiei, additional

Published
2015
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219. Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy

Author

Saida, Yu, primary, Watanabe, Satoshi, additional, Tanaka, Tomohiro, additional, Baba, Junko, additional, Sato, Ko, additional, Shoji, Satoshi, additional, Igarashi, Natsue, additional, Kondo, Rie, additional, Okajima, Masaaki, additional, Koshio, Jun, additional, Ichikawa, Kosuke, additional, Nozaki, Koichiro, additional, Ishikawa, Daisuke, additional, Koya, Toshiyuki, additional, Miura, Satoru, additional, Tanaka, Junta, additional, Kagamu, Hiroshi, additional, Yoshizawa, Hirohisa, additional, Nakata, Koh, additional, and Narita, Ichiei, additional

Published
2015
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220. The efficacy of amrubicin on central nervous system metastases originating from small-cell lung cancer: a case series of eight patients

Author

Miura, Satoru, primary, Kaira, Kyoichi, additional, Kaira, Rieko, additional, Akamatsu, Hiroaki, additional, Ono, Akira, additional, Shukuya, Takehito, additional, Tsuya, Asuka, additional, Nakamura, Yukiko, additional, Kenmotsu, Hirotsugu, additional, Naito, Tateaki, additional, Murakami, Haruyasu, additional, Takahashi, Toshiaki, additional, Endo, Masahiro, additional, and Yamamoto, Nobuyuki, additional

Published
2015
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221. Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis

Author

Miura, Satoru, primary, Kagamu, Hiroshi, additional, Sakai, Takehito, additional, Nozaki, Koichiro, additional, Asakawa, Katsuaki, additional, Moro, Hiroshi, additional, Okajima, Masaaki, additional, Watanabe, Satoshi, additional, Yamamoto, Suguru, additional, Iino, Noriaki, additional, Goto, Shin, additional, Kazama, Junichiro James, additional, Yoshizawa, Hirohisa, additional, and Narita, Ichiei, additional

Published
2015
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223. A phase II study of erlotinib monotherapy in pre-treated non-small cell lung cancer without EGFR gene mutation who have never/light smoking history: Re-evaluation of EGFR gene status (NEJ006/TCOG0903)

Author

Matsumoto, Yoshifumi, primary, Maemondo, Makoto, additional, Ishii, Yoshiki, additional, Okudera, Koichi, additional, Demura, Yoshiki, additional, Takamura, Kei, additional, Kobayashi, Kunihiko, additional, Morikawa, Naoto, additional, Gemma, Akihiko, additional, Ishimoto, Osamu, additional, Usui, Kazuhiro, additional, Harada, Masao, additional, Miura, Satoru, additional, Fujita, Yuka, additional, Sato, Ikuro, additional, and Saijo, Yasuo, additional

Published
2014
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224. Analysis of heavy metal pollution in soil using transversely excited atmospheric CO2 laser-induced plasma by trapping the soil in microstructured holes on metal subtargets

Author

Kiichiro Kagawa, Nasrullah Idris, Miura Satoru, Fujio Sakan, and Kenichiro Tsuyuki

Subjects
Materials science, Atmospheric pressure, Soil test, 010401 analytical chemistry, Analytical chemistry, Plasma, Trapping, 01 natural sciences, 0104 chemical sciences, 010309 optics, Metal, Excited state, visual_art, 0103 physical sciences, visual_art.visual_art_medium, Irradiation, Instrumentation, Quartz, Spectroscopy
Abstract

A unique technique for direct analysis of soil samples utilizing a special advantage of a transversely excited atmospheric (TEA) CO2 laser-induced plasma generated at atmospheric pressure on a metal target has been developed. In this technique, a metal subtarget, such as nickel plate, structured with intentional microholes on its surface, each with dimensions of around 100 μm in diameter and depth, was used to selectively trap small sized soil particles by immersing the metal plate subtarget into the polluted soil sample. The trapped small soil particles on the metal subtarget were irradiated by a TEA CO2 laser (10.6 μm, 1.5 J, 200 ns) at atmospheric pressure under defocused condition with a spot size of 3 mm × 3 mm. This trapping and confining scheme substantially suppresses the blowing off effect; thus, the trapped soil particles can effectively be dissociated and atomized in the microstructured holes. Using this method of a microstructured metal plate subtarget, quantitative analysis was carried out on loam soil samples polluted by Pb. A linear calibration curve was obtained with a detection limit of approximately 50 mg/kg. Preliminary quantitative studies were carried out for a quartz sand sample containing Cr and Hg, resulting in linear calibration curves with detection limits of approximately 25 mg/kg and 10 mg/kg, respectively, at this stage. This technique is promising as a potential field screening tool for soil analysis.

Published
2008

226. Carbon analysis for inspecting carbonation of concrete using a TEA CO2 laser-induced plasma

Author

Hendrik Kurniawan, Nasrullah Idris, Kenichiro Tsuyuki, Munehide Wada, Kiichiro Kagawa, and Miura Satoru

Subjects
Materials science, Carbonation, 010401 analytical chemistry, Mineralogy, chemistry.chemical_element, Plasma, Laser, 01 natural sciences, Chemical reaction, 0104 chemical sciences, law.invention, Phenolphthalein, 010309 optics, chemistry.chemical_compound, chemistry, law, 0103 physical sciences, Degradation (geology), Irradiation, Composite material, Instrumentation, Carbon, Spectroscopy
Abstract

It has been demonstrated that a spectrochemical analysis of carbon using the laser plasma method can be successfully applied to inspect the carbonation of concrete by detecting carbon produced in aged concrete by a chemical reaction of Ca(OH)2 with CO2 gas in environmental air, turning into CaCO3, which induces degradation of the quality of building concrete. A comparative study has been made using a TEA CO2 laser (500–1000 mJ) and a Q-switched Nd– YAG laser (50–200 mJ) to search for the optimum conditions for carbon analysis, proving the advantage of the TEA CO2 laser for this purpose. Also, it was clarified that laser irradiation with suitable defocusing conditions is a crucial point for obtaining high sensitivity in the detection of carbon. Practical experiments on the inspection of carbonation were carried out using both a concrete sample that had been intentionally carbonated by exposure to high concentrations of CO2 gas and a naturally carbonated concrete sample. As a result, good coincidence was observed between the laser method and the ordinary method, which uses the chemical indicator phenolphthalein, implying that this laser technique is applicable as an in situ quantitative method of inspection for carbonation of concrete.

Published
2007

227. O6-3 The significance of ultra-low EGFR T790M mutations on EGFR-TKI efficacy in patients with NSCLC -the WJOG13119L study.

Author

Masuda, Takeshi, Miura, Satoru, Koso, Hidenori, Yanagihara, Kazuhiro, Okamoto, Tatsuro, Shoda, Hiroyasu, Shimizu, Junichi, Kanaji, Nobuhiro, Hara, Satoshi, Sakata, Shinya, Tokito, Takaaki, Kashiwabara, Kosuke, Nishikawa, Kazuo, Watanabe, Hiroshi, Maeno, Ken, Suzuki, Shigeki, Hayakawa, Daisuke, Yamamoto, Nobuyuki, Nakagawa, Kazuhiko, and Noboru, Hattori

Subjects
*EPIDERMAL growth factor receptors, *KINASE inhibitors, *NON-small-cell lung carcinoma, *PATIENTS
Published
2022
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228. Measurement of concrete strength using the emission intensity ratio between Ca(II) 396.8 nm and Ca(I) 422.6 nm in a Nd:YAG laser-induced plasma

Author

Kenichiro Tsuyuki, Tjung Jie Lie, Kiichiro Kagawa, Nasrullah Idris, Miura Satoru, and Koo Hendrik Kurniawan

Subjects
Shock wave, Materials science, Hot Temperature, Compressive Strength, Analytical chemistry, 01 natural sciences, law.invention, 010309 optics, Photometry, law, Ionization, 0103 physical sciences, Materials Testing, Emission spectrum, Laser-induced breakdown spectroscopy, Instrumentation, Spectroscopy, Construction Materials, Lasers, Spectrum Analysis, 010401 analytical chemistry, Plasma, Laser, 0104 chemical sciences, Compressive strength, Nd:YAG laser, Calcium, Gases
Abstract

An experiment to investigate the potential of a laser-induced plasma method for determining concrete compressive strength was conducted by focusing a Nd:YAG laser on concrete samples with different degrees of compressive strength. This technique was developed in light of the role of the shock wave in the generation of a laser-induced plasma. It was found that the speed of the shock front depends on the hardness of the sample. It was also found that a positive relationship exists between the speed of the shock front and the ionization rate of the ablated atoms. Hence, the ratio of the intensity between the Ca(II) 396.8 nm and Ca(I) 422.6 nm emission lines detected from the laser-induced plasma can be used to examine the hardness of the material. In fact, it was observed that the ratio changes with respect to the change in the concrete compressive strength. The findings also show that the ratio increases with time after the cement is mixed with water.

Published
2006

229. A phase II study of carboplatin plus weekly paclitaxel with bevacizumab for elderly patients with non-squamous non-small-cell lung cancer (NEJ016).

Author

Miura, Satoru, Maemondo, Makoto, Iwashima, Akira, Harada, Toshiyuki, Sugawara, Shunichi, Kobayashi, Kunihiko, Inoue, Akira, Nakagawa, Taku, Takiguchi, Yuichi, Watanabe, Hiroshi, Ishida, Takashi, Terada, Masaki, Kagamu, Hiroshi, Gemma, Akihiko, and Yoshizawa, Hirohisa

Abstract

Background The efficacy and safety of bevacizumab in elderly patients with non-small cell lung cancer remain controversial. This study focused on both selecting fit elderly patients and overcoming interpatient variability with respect to pharmacodynamics. Methods Elderly (age: ≥70 years) patients with advanced non-squamous non-small cell lung cancer were enrolled. Patients with uncontrolled congestive heart failure and uncontrolled diabetes were excluded. The treatment regimen comprised carboplatin at an area under the curve of 5 mg/ml/min on day 1, paclitaxel at 90 mg/m on days 1 and 8, and bevacizumab at 15 mg/kg on day 1 every 21 days for up to 4 cycles, followed by maintenance bevacizumab. Dose reduction due to side effects was performed, with a wide range of doses of paclitaxel from 23 mg/m/week to 60 mg/m/week. Results Of the 36 patients entered, 38.9% required a dose reduction or cancellation of paclitaxel administration on day 8, and 75% patients were able to complete 4 cycles of triplet therapy. The response rate, primary endpoint, was 69.4% (95% confidence interval [CI]: 51.9-83.7). The median progression free survival and overall survival were 8.4 months and 29.2 months, respectively. The most common adverse events included neutropenia, hypertension, anemia, and infection. Although Grade ≥ 3 adverse events were observed in 24 patients (66.7%), there were no deaths due to toxicity. Conclusion Carboplatin plus weekly paclitaxel with bevacizumab is a feasible, effective first-line regimen for elderly non-small cell lung cancer patients. (UMIN00006622). [ABSTRACT FROM AUTHOR]

Published
2017
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231. Outcomes of Chemoimmunotherapy Among Patients With Extensive-Stage Small Cell Lung Cancer According to Potential Clinical Trial Eligibility.

Author

Fujimoto, Daichi, Morimoto, Takeshi, Tamiya, Motohiro, Hata, Akito, Matsumoto, Hirotaka, Nakamura, Atsushi, Yokoyama, Toshihide, Taniguchi, Yoshihiko, Uchida, Junji, Sato, Yuki, Yokoi, Takashi, Tanaka, Hisashi, Furuya, Naoki, Masuda, Takeshi, Sakata, Yoshihiko, Miyauchi, Eisaku, Hara, Satoshi, Saito, Go, Miura, Satoru, and Kanazu, Masaki

Published
2023
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235. Abstract 2818: Dendritic cell vaccination and regulatory T-cell depletion augment antitumor immunity after cytotoxic therapy

Author

Tanaka, Tomohiro, primary, Watanabe, Satoshi, additional, Sato, Ko, additional, Saida, Yu, additional, Baba, Junko, additional, Nozaki, Koichiro, additional, Ishikawa, Daisuke, additional, Igarashi, Natsue, additional, Shoji, Satoshi, additional, Okajima, Masaaki, additional, Miura, Satoru, additional, Tanaka, Junta, additional, Tanaka, Hiroshi, additional, Kagamu, Hiroshi, additional, Yoshizawa, Hirohisa, additional, and Narita, Ichiei, additional

Published
2014
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237. Abstract 200: DDX3X induces signal switching to stem cell-specific Wnt/β-catenin signaling, resulting in EGFR-TKI resistance in lung cancer cells harboring EGFR activating mutation

Author

Shoji, Satoshi, primary, Kagamu, Hiroshi, additional, Nozaki, Koichiro, additional, Igarashi, Natsue, additional, Okajima, Masaaki, additional, Miura, Satoru, additional, Watanabe, Satoshi, additional, Yoshizawa, Hrohisa, additional, and Narita, Ichiei, additional

Published
2014
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239. Phase I study of dose-dense chemotherapy (DDC) alternating cisplatin (CDDP), topotecan (TPT), and paclitaxel (PTX) with CDDP, amrubicin (AMR), and PTX under granulocyte colony-stimulating factor support for extensive-stage small-cell lung cancer (ES-SCLC).

Author

Tanaka, Junta, primary, Watanabe, Satoshi, additional, Kagamu, Hiroshi, additional, Ishikawa, Daisuke, additional, Nozaki, Koichiro, additional, Tanaka, Tomohiro, additional, Okajima, Masaaki, additional, Miura, Satoru, additional, Narita, Ichiei, additional, and Yoshizawa, Hirohisa, additional

Published
2014
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247. ペメトレキセドを含むプラチナ併用化学療法により長期生存が得られた原発性心膜悪性中皮腫の1例

Author

田中, 知宏, 才田, 優, 庄子, 聡, 野嵜, 幸一郎, 五十嵐, 夏恵, 佐藤, 昂, 岡島, 正明, 三浦, 理, 田中, 純太, 青木, 信将, 小屋, 俊之, 各務, 博, 成田, 一衛, 渡部, 聡, 吉澤, 弘久, 篠原, 博彦, 土田, 正則, 清水, 崇, Tanaka, Tomohiro, Saida, Yu, Shoji, Satoshi, Nozaki, Koichiro, Igarashi, Natsue, Sato, Ko, Okajima, Masaaki, Miura, Satoru, Tanaka, Junta, Aoki, Nobumasa, Koya, Toshiyuki, Kagamu, Hiroshi, Narita, Ichiei, Watanabe, Satoshi, Yoshizawa, Hirohisa, Shinohara, Hirohiko, Tsuchida, Masanori, Shimizu, Takashi, 田中, 知宏, 才田, 優, 庄子, 聡, 野嵜, 幸一郎, 五十嵐, 夏恵, 佐藤, 昂, 岡島, 正明, 三浦, 理, 田中, 純太, 青木, 信将, 小屋, 俊之, 各務, 博, 成田, 一衛, 渡部, 聡, 吉澤, 弘久, 篠原, 博彦, 土田, 正則, 清水, 崇, Tanaka, Tomohiro, Saida, Yu, Shoji, Satoshi, Nozaki, Koichiro, Igarashi, Natsue, Sato, Ko, Okajima, Masaaki, Miura, Satoru, Tanaka, Junta, Aoki, Nobumasa, Koya, Toshiyuki, Kagamu, Hiroshi, Narita, Ichiei, Watanabe, Satoshi, Yoshizawa, Hirohisa, Shinohara, Hirohiko, Tsuchida, Masanori, and Shimizu, Takashi

Abstract

症例は71歳男性. 上縦隔腫瘤, 左胸水, 心嚢液貯留の精査目的に当科を紹介され入院した. 心嚢水セルブロック法による組織学的診断で上皮型原発性心膜悪性中皮腫と診断された. ペメトレキセドとプラチナ併用化学療法を計4コース施行し, stable diseaseが得られた. 2013年5月現在, 抗癌剤の最終投与日から約18か月間が経過し無増悪生存中である. 原発性心膜悪性中皮腫は稀であり, 標準治療は確立されていない. 本症例から, ペメトレキセドを含むプラチナ併用化学療法が有効である可能性が示唆された.

Published
2013

249. 副腎転移巣から出血をきたした肺癌と胃癌の重複癌の1例

Author

才田, 優, 田中, 知宏, 野嵜, 幸一郎, 市川, 紘将, 古塩, 純, 三浦, 理, 各務, 博, 成田, 一衛, 渡部, 聡, 田中, 純太, 吉澤, 弘久, 櫛谷, 幸嗣, 阿部, 徹哉, 丸山, 佳重, Saida, Yu, Tanaka, Tomohiro, Nozaki, Koichiro, Ichikawa, Kosuke, Koshio, Jun, Miura, Satoru, Kagamu, Hiroshi, Narita, Ichiei, Watanabe, Satoshi, Tanaka, Junta, Yoshizawa, Hirohisa, Kushiya, Koji, Abe, Tetsuya, Maruyama, Yoshie, 才田, 優, 田中, 知宏, 野嵜, 幸一郎, 市川, 紘将, 古塩, 純, 三浦, 理, 各務, 博, 成田, 一衛, 渡部, 聡, 田中, 純太, 吉澤, 弘久, 櫛谷, 幸嗣, 阿部, 徹哉, 丸山, 佳重, Saida, Yu, Tanaka, Tomohiro, Nozaki, Koichiro, Ichikawa, Kosuke, Koshio, Jun, Miura, Satoru, Kagamu, Hiroshi, Narita, Ichiei, Watanabe, Satoshi, Tanaka, Junta, Yoshizawa, Hirohisa, Kushiya, Koji, Abe, Tetsuya, and Maruyama, Yoshie

Abstract

症例は60歳, 男性. 2008年8月より湿性咳嗽が出現した. 10月のCTで左肺上葉に45mm大の腫瘤影と両側肺門・縦隔・噴門部・傍大動脈リンパ節の腫大を認めた. 気管支鏡検査, 上部消化管内視鏡検査により, 非小細胞肺癌, 胃癌の同時重複癌と診断した. 全身化学療法を施行したが徐々に原病は進行し, 2009年7月1日のCTでは新たに両側副腎転移巣を認めた. 2009年7月24日から腹痛, 7月28日から発熱が出現した. 7月29日のCTで右副腎転移巣の著明な増大, 内部に高濃度域を認め, 副腎出血と診断した. 悪性腫瘍の副腎転移巣から出血を来す症例は稀であり, 文献的考察を加え報告する.

Published
2012

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