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201. Evaluation of cardiac output variations with the peripheral pulse pressure to mean arterial pressure ratio

Author: Audrey Tantot, Etienne Gayat, Joaquim Mateo, Anais Caillard, Alexandre Mebazaa, Sandrine Millasseau, Fabrice Vallée, Arthur Le Gall, Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, Institut National de la Santé et de la Recherche Médicale (INSERM), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Pulse wave consulting [Saint-Leu-la-forêt], École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Adult, Male, medicine.medical_specialty, Cardiac output, Mean arterial pressure, Operating Rooms, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Systole, Health Informatics, Blood Pressure, Critical Care and Intensive Care Medicine, Positive correlation, Neurosurgical Procedures, 03 medical and health sciences, Norepinephrine, Phenylephrine, 0302 clinical medicine, Bolus (medicine), [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 030202 anesthesiology, Heart Rate, Internal medicine, medicine, Humans, Vasoconstrictor Agents, Anesthesia, Arterial Pressure, Ephedrine, Cardiac Output, ComputingMilieux_MISCELLANEOUS, Aged, Monitoring, Physiologic, business.industry, Hemodynamics, 030208 emergency & critical care medicine, Stroke Volume, Ultrasonography, Doppler, Middle Aged, Pulse pressure, Peripheral, Anesthesiology and Pain Medicine, Cardiology, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, business, medicine.drug
Abstract: Cardiac output (CO) optimisation during surgery reduces post-operative morbidity. Various methods based on pulse pressure analysis have been developed to overcome difficulties to measure accurate CO variations in standard anaesthetic settings. Several of these methods include, among other parameters, the ratio of pulse pressure to mean arterial pressure (PP/MAP). The aim of this study was to evaluate whether the ratio of radial pulse pressure to mean arterial pressure (ΔPPrad/MAP) could track CO variations (ΔCO) induced by various therapeutic interventions such as fluid infusions and vasopressors boluses [phenylephrine (PE), norepinephrine (NA) or ephedrine (EP)] in the operating room. Trans-oesophageal Doppler signal and pressure waveforms were recorded in patients undergoing neurosurgery. CO and PPrad/MAP were recorded before and after fluid challenges, PE, NA and EP bolus infusions as medically required during their anaesthesia. One hundred and three patients (mean age: 52 ± 12 years old, 38 men) have been included with a total of 636 sets of measurement. During fluids challenges (n = 188), a positive correlation was found between ΔPPrad/MAP and ΔCO (r = 0.22, p = 0.003). After PE (n = 256) and NA (n = 121) boluses, ΔPPrad/MAP positively tracked ΔCO (r = 0.53 and 0.41 respectively, p
Published: 2018

202. Well-posedness and convergence of the Lindblad master equation for a quantum harmonic oscillator with multi-photon drive and damping

Author: Alain Sarlette, Remi Azouit, Pierre Rouchon, QUANTum Information Circuits (QUANTIC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre Automatique et Systèmes (CAS), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Mines Paris - PSL (École nationale supérieure des mines de Paris), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: Infinite-dimensional dissipative dynamical systems, Lindblad master equation, 0209 industrial biotechnology, Technology and Engineering, Control and Optimization, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], Banach space, FOS: Physical sciences, 37L99, 47B44, 81Q93, 81S22, 81V10, 02 engineering and technology, 01 natural sciences, [SPI.AUTO]Engineering Sciences [physics]/Automatic, [SPI]Engineering Sciences [physics], 020901 industrial engineering & automation, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], infinite-dimensional dissipative dynamical systems, 0103 physical sciences, Master equation, Invariant (mathematics), decoherence, 010306 general physics, Mathematical Physics, Mathematics, Quantum Physics, quantum electrodynamics and circuits, Mathematical analysis, Invariant subspace, Observable, Mathematical Physics (math-ph), State (functional analysis), accretive operators, Computational Mathematics, Lyapunov functions and stability, Control and Systems Engineering, Quantum harmonic oscillator, Coherent states, IBCN, Quantum Physics (quant-ph), quantum control
Abstract: We consider the model of a quantum harmonic oscillator governed by a Lindblad master equation where the typical drive and loss channels are multi-photon processes instead of single-photon ones; this implies a dissipation operator of order 2k with integer k>1 for a k-photon process. We prove that the corresponding PDE makes the state converge, for large time, to an invariant subspace spanned by a set of k selected basis vectors; the latter physically correspond to so-called coherent states with the same amplitude and uniformly distributed phases. We also show that this convergence features a finite set of bounded invariant functionals of the state (physical observables), such that the final state in the invariant subspace can be directly predicted from the initial state. The proof includes the full arguments towards the well-posedness of the corresponding dynamics in proper Banach spaces of Hermitian trace-class operators equipped with adapted nuclear norms. It relies on the Hille-Yosida theorem and Lyapunov convergence analysis., 20 pages, submitted
Published: 2016

203. On the Reachable States for the Boundary Control of the Heat Equation

Author: Pierre Rouchon, Philippe Martin, Lionel Rosier, Centre Automatique et Systèmes (CAS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), QUANTum Information Circuits (QUANTIC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MINES ParisTech - École nationale supérieure des mines de Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-MINES ParisTech - École nationale supérieure des mines de Paris, Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: 0209 industrial biotechnology, Boundary (topology), exact controllability, 02 engineering and technology, 01 natural sciences, Square (algebra), Borel theorem, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Mathematics - Analysis of PDEs, 020901 industrial engineering & automation, FOS: Mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Gevrey functions, 0101 mathematics, Gevrey class, Mathematics, Parabolic equation, Applied Mathematics, 010102 general mathematics, Mathematical analysis, Function (mathematics), Computational Mathematics, Square-integrable function, reachable states, Heat equation, Analysis, Analysis of PDEs (math.AP), flatness, Analytic function, Interpolation
Abstract: International audience; We are interested in the determination of the reachable states for the boundary control of the one-dimensional heat equation. We consider either one or two boundary controls. We show that reachable states associated with square integrable controls can be extended to analytic functions on some square of C, and conversely, that analytic functions defined on a certain disk can be reached by using boundary controlsthat are Gevrey functions of order 2. The method of proof combines the flatness approach with some new Borel interpolation theorem in some Gevrey class with a specified value of the loss in the uniform estimates of the successive derivatives of the interpolating function.
Published: 2016

204. An energy-based strategy for fatigue analysis in presence of general multi-axial time varying loadings

Author: Zepeng Ma, Patrick Le Tallec, Habibou Maitournam, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), We are grateful for the financial and technical support of Chaire PSA André Citroën and for the continuous advice of Ida Raoult. This work was supported by the ANR under contract number ANR-10-EQPX-37., ANR-10-EQPX-0037,MATMECA,MATériaux-MECAnique/Elaboration-Caractérisation-Observation-Modélisation-Simulation(2010), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Plasticity, [SPI.MECA.MSMECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], 02 engineering and technology, High cycle, Industrial and Manufacturing Engineering, 0203 mechanical engineering, General Materials Science, Point (geometry), Fatigue, Physics, Mesoscopic physics, Energy, Mean stress, Mechanical Engineering, Mechanics, Dissipation, 021001 nanoscience & nanotechnology, Shakedown, Nonlinear system, 020303 mechanical engineering & transports, Mechanics of Materials, Macroscopic scale, Modeling and Simulation, 0210 nano-technology, Energy (signal processing)
Abstract: International audience; The purpose of this paper is to propose an energy based multi-scale fatigue approach which handles multidimensional time varying loading histories.Our fundamental thought is to assume that the energy dissipated at small scales governs fatigue at failure in a nonlinear additive way. We follow the Dang Van paradigm at macro scale. The structure is elastic at the macroscopic scale. At each material point, there is a stochastic distribution of weak points which will undergo strong plastic yielding, which contribute to energy dissipation without affecting the overall macroscopic stress. A kinematic hardening under the assumption of associative plasticity is also considered.Instead of using the number of cycles, we use the concept of multi-scale damage accumulation during the considered load history. A concise non-linear damage accumulation law is also proposed in our model. Fatigue will then be determined from the plastic shakedown cycle and from a phenomenological fatigue law linking lifetime and accumulated mesoscopic plastic dissipation.
Published: 2020

205. Fractal catastrophes

Author: J Meibohm, K Gustavsson, J Bec, B Mehlig, Department of Physics (Göthenburg), University of Gothenburg (GU), Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Stochastic Approaches for Complex Flows and Environment (CALISTO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Statistical Mechanics (cond-mat.stat-mech), Fluid Dynamics (physics.flu-dyn), FOS: Physical sciences, General Physics and Astronomy, Physics - Fluid Dynamics, Nonlinear Sciences - Chaotic Dynamics, 01 natural sciences, 010305 fluids & plasmas, [NLIN.NLIN-CD]Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD], 0103 physical sciences, [PHYS.COND.CM-SM]Physics [physics]/Condensed Matter [cond-mat]/Statistical Mechanics [cond-mat.stat-mech], Chaotic Dynamics (nlin.CD), 010306 general physics, Condensed Matter - Statistical Mechanics
Abstract: We analyse the spatial inhomogeneities ('spatial clustering') in the distribution of particles accelerated by a force that changes randomly in space and time. To quantify spatial clustering, the phase-space dynamics of the particles must be projected to configuration space. Folds of a smooth phase-space manifold give rise to catastrophes ('caustics') in this projection. When the inertial particle dynamics is damped by friction, however, the phase-space manifold converges towards a fractal attractor. It is believed that caustics increase spatial clustering also in this case, but a quantitative theory is missing. We solve this problem by determining how projection affects the distribution of finite-time Lyapunov exponents. Applying our method in one spatial dimension we find that caustics arising from the projection of a dynamical fractal attractor ('fractal catastrophes') make a distinct and universal contribution to the distribution of spatial finite-time Lyapunov exponents. Our results explain a projection formula for the spatial fractal correlation dimension, and how a fluctuation relation for the distribution of finite-time Lyapunov exponents for white-in-time Gaussian force fields breaks upon projection. We explore the implications of our results for heavy particles in turbulence, and for wave propagation in random media., Comment: 32 pages, 7 figures
Published: 2020

206. Quantification of Biventricular Strains in Heart Failure With Preserved Ejection Fraction Patient Using Hyperelastic Warping Method

Author: Hua Zou, Ce Xi, Xiaodan Zhao, Angela S. Koh, Fei Gao, Yi Su, Ru-San Tan, John Allen, Lik Chuan Lee, Martin Genet, Liang Zhong, National Heart Centre Singapore (NHCS), Michigan State University [East Lansing], Michigan State University System, Duke-NUS Medical School [Singapore], Agency for science, technology and research [Singapore] (A*STAR), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), This research was supported in part by grants from the National Medical Research Council (NMRC/OFIRG/0018/2016,NMRC/MOH1AFCAT2/0002/2014, and NMRC/BnB/0017/2015), Biomedical Engineering Programme, Agency for Science,Technology and Research, Singapore Project Grant (132148 0012), National Medical Research Council of Singapore (NMRC/TA/0031/2015), Hong Leong Foundation, Duke-NUSMedical School and the 'Estate of Tan Sri Khoo Teck Puat', and the Biomedical Research Council (14/1/32/24/002), America Heart Association (17SDG33370110, LCL), National Institutes of Health (R01 HL 134841-01A1 and U01 HL133359-01A1, LCL), and National Science Foundation (NSF 1702987, LCL.)., École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: heart failure with preserved ejection fraction, medicine.medical_specialty, Ventricular Ejection Fraction, left ventricle, Physiology, 0206 medical engineering, 02 engineering and technology, right ventricle, hyperelastic warping, 030204 cardiovascular system & hematology, lcsh:Physiology, 03 medical and health sciences, strain, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Physiology (medical), Internal medicine, Healthy control, medicine, Original Research, Ejection fraction, lcsh:QP1-981, business.industry, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], medicine.disease, 020601 biomedical engineering, 3. Good health, medicine.anatomical_structure, Ventricle, Heart failure, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Cardiology, Cardiac magnetic resonance, business, Heart failure with preserved ejection fraction, Radial stress
Abstract: Heart failure (HF) imposes a major global health care burden on society and suffering on the individual. About 50% of HF patients have preserved ejection fraction (HFpEF). More intricate and comprehensive measurement-focused imaging of multiple strain components may aid in the diagnosis and elucidation of this disease. Here, we describe the development of a semi-automated hyperelastic warping method for rapid comprehensive assessment of biventricular circumferential, longitudinal, and radial strains that is physiological meaningful and reproducible. We recruited and performed cardiac magnetic resonance (CMR) imaging on 30 subjects [10 HFpEF, 10 HF with reduced ejection fraction patients (HFrEF) and 10 healthy controls]. In each subject, a three-dimensional heart model including left ventricle (LV), right ventricle (RV), and septum was reconstructed from CMR images. The hyperelastic warping method was used to reference the segmented model with the target images and biventricular circumferential, longitudinal, and radial strain–time curves were obtained. The peak systolic strains are then measured and analyzed in this study. Intra- and inter-observer reproducibility of the biventricular peak systolic strains was excellent with all ICCs > 0.92. LV peak systolic circumferential, longitudinal, and radial strain, respectively, exhibited a progressive decrease in magnitude from healthy control→HFpEF→HFrEF: control (-15.5 ± 1.90, -15.6 ± 2.06, 41.4 ± 12.2%); HFpEF (-9.37 ± 3.23, -11.3 ± 1.76, 22.8 ± 13.1%); HFrEF (-4.75 ± 2.74, -7.55 ± 1.75, 10.8 ± 4.61%). A similar progressive decrease in magnitude was observed for RV peak systolic circumferential, longitudinal and radial strain: control (-9.91 ± 2.25, -14.5 ± 2.63, 26.8 ± 7.16%); HFpEF (-7.38 ± 3.17, -12.0 ± 2.45, 21.5 ± 10.0%); HFrEF (-5.92 ± 3.13, -8.63 ± 2.79, 15.2 ± 6.33%). Furthermore, septum peak systolic circumferential, longitudinal, and radial strain magnitude decreased gradually from healthy control to HFrEF: control (-7.11 ± 1.81, 16.3 ± 3.23, 18.5 ± 8.64%); HFpEF (-6.11 ± 3.98, -13.4 ± 3.02, 12.5 ± 6.38%); HFrEF (-1.42 ± 1.36, -8.99 ± 2.96, 3.35 ± 2.95%). The ROC analysis indicated LV peak systolic circumferential strain to be the most sensitive marker for differentiating HFpEF from healthy controls. Our results suggest that the hyperelastic warping method with the CMR-derived strains may reveal subtle impairment in HF biventricular mechanics, in particular despite a “normal” ventricular ejection fraction in HFpEF.
Published: 2018

207. Delayed feedback control method for computing the cyclic steady states of evolution problems

Author: Patrick Le Tallec, Ustim Khristenko, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Work (thermodynamics), Computer science, Mechanical Engineering, Computational Mechanics, General Physics and Astronomy, 010103 numerical & computational mathematics, [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], Space (mathematics), 01 natural sciences, Computer Science Applications, Term (time), Mechanics of Materials, Limit cycle, 0103 physical sciences, Convergence (routing), Applied mathematics, Initial value problem, Transient (computer programming), Limit (mathematics), 0101 mathematics, 010306 general physics, ComputingMilieux_MISCELLANEOUS
Abstract: This work is focused on fast techniques for computing the cyclic steady states of evolution problems in non-linear mechanics with space–time periodicity conditions. In industrial applications, in order to avoid the inversion of very large matrices, such a cyclic solution is usually computed as an asymptotic limit of the associated initial value problem with arbitrary initial data. However, when the relaxation time is high, convergence to the limit cycle can be very slow. In such cases nonetheless, one is not interested in the transient solution, but only in a fast access to the limit cycle. Thus, in this work we modify the problem, introducing the time-delayed feedback control, which is widely used for stabilization of unstable periodic orbits. In our framework it is applied to an initially stable system in order to accelerate its convergence to the limit cycle. Moreover, the control term, based on the space–time periodicity error, includes both shifts in time and in space. Our main result is the optimal form of the control term for a very general class of linear evolution problems, providing the fastest convergence to the cyclic solution, which has been further extended and studied in the non-linear case . Efficiency of the method increases with the problem’s relaxation time. The method has been tested using academic applications and compared to the non-controlled asymptotic convergence as well as to the Newton–Krylov shooting algorithm. Finally, the method has been implemented into the Michelin industrial code, applied to a full 3D rolling tyre model.
Published: 2018

208. Perioperative management of patients with coronary artery disease undergoing non-cardiac surgery: Summary from the French Society of Anaesthesia and Intensive Care Medicine 2017 convention

Author: Deborah Benchetrit, Etienne Gayat, Sebastien Pili-Floury, Anne-Céline Martin, Jean-Luc Fellahi, Valérie Billard, Rémi Schweizer, Dan Longrois, Thomas Bochaton, Sophie Jenck, Alex Hong, Francis Berthier, Arthur Le Gall, Pierre Coriat, Guillaume Besch, Bertrand Rozec, Anne Godier, Sophie Provenchère, Eric Bonnefoy-Cudraz, Emmanuel Samain, Vincent Piriou, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Fondation Ophtalmologique Adolphe de Rothschild [Paris], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Département d'Anesthésie Réanimation SMUR [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service d'anesthésie - réanimation chirurgicale [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département d'anesthésie [Gustave Roussy], Institut Gustave Roussy (IGR), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) (PCVP / CARDIO), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), CHU Pitié-Salpêtrière [APHP], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université de Franche-Comté (UFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'anesthésie et de réanimation [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Hôpital Jean Minjoz, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), and Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
Subjects: medicine.medical_specialty, education, Heart team, Guidelines as Topic, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Coronary artery disease, Perioperative Care, Perioperative medicine, 03 medical and health sciences, 0302 clinical medicine, Non-cardiac surgery, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 030202 anesthesiology, Cardiac risk, medicine, Humans, Intensive care medicine, Perioperative management, business.industry, General Medicine, medicine.disease, 3. Good health, Anesthesiology and Pain Medicine, Postoperative Periods, Elective Surgical Procedures, Non cardiac surgery, France, business
Abstract: International audience; This review summarises the specific stakes of preoperative, intraoperative, and postoperative periods of patients with coronary artery disease undergoing non-cardiac surgery. All practitioners involved in the perioperative management of such high cardiac risk patients should be aware of the modern concepts expected to decrease major adverse cardiac events and improve short- and long-term outcomes. A multidisciplinary approach via a functional heart team including anaesthesiologists, cardiologists and surgeons must be encouraged. Rational and algorithm-guided management of those patients should be known and implemented from preoperative to postoperative period.
Published: 2018

209. Modeling (some aspects of) the female reproductive system : Gonadotropin and follicular dynamics

Author: Clement, Frederique, Monniaux, Danielle, Postel, Marie, Robin, Frédérique, Yvinec, Romain, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Yvinec, Romain, Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

210. A continuum relaxed growth model for controlling growth-induced residual stresses in living tissues

Author: Genet, Martin, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: [INFO.INFO-CE]Computer Science [cs]/Computational Engineering, Finance, and Science [cs.CE], [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Abstract: International audience; Living tissues are naturally prestrained (or, equivalently, residually stressed), as clearly illustrated by Y.C. Fung's famous opening angle experiment on arteries [1]. If the biomechanical role of residual stresses has been well described for many tissues, their origin remains an open question; growth, however, is a likely candidate. Indeed, differential (i.e., heterogeneous) growth induces residual stresses, in order to accommodate for the non-compatible growth [2]. In continuum models of growth, growth-induced residual stresses have been either kept [2] or dismissed [3], depending on the modeling objective: growth-induced residual stresses allow to quantitatively reproduce the opening angle experiments on the left ventricle [2], on the other hand they can lead to inconsistencies in the mechanical response of hypertrophied ventricles [3]. Moreover, only a partial organ growth is required to induce residual stresses that are compatible with measured opening angle [2], suggesting that not all residual stresses induced by the complete growth process are present in the mature organ. In this work I propose a new model of soft tissue biomechanics, including both strain-or stress-driven growth as well as relaxation of residual stresses. It is written in the general framework of finite deformation continuum mechanics, and based on the multiplicative decomposition of the deformation gradient as illustrated on the figure: the reference configuration, denoted \Omega_0, with prestrain field \F_0, deforms into the current configuration \Omega through mapping \Phi with gradient \F = \nabla\Phi; now the total transformation is composed into growth, prestrain, relaxation and loading parts such that the elastic deformation gradient is \F_e = \F \F'^-1 \F_r \F_p \F_0. In addition to the constitutive relation that relates this elastic deformation gradient to stress, two additional evolution laws are needed to close the model: for growth, and relaxation. Depending on the ratio between the time constants of both laws, the models allows controlling the part of growth-induced residual stresses that is kept in the tissue vs. the part that is relaxed away. From the computational perspective, in order to compute all terms in \F_e, two computations must be performed in parallel: the deformed configuration \Omega, obviously, but also the unloaded configuration \Omega_r.
Published: 2018

211. Equilibrated Warping: Finite Element Image Registration with Equilibrium Gap Regularization

Author: Genet, Martin, Stoeck, Christian, Berberoglu, Ezgi, Kozerke, Sebastian, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institute for Biomedical Engineering [ETH Zürich] (IBT), Universität Zürich [Zürich] = University of Zurich (UZH)-Department of Information Technology and Electrical Engineering [Zürich] (D-ITET), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Physics::Medical Physics, [SPI.MECA.SOLID]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph]
Abstract: International audience; Image processing, in particular motion tracking, is playing an important role in biomedical engineering and in other domains such as materials and mechanical engineering. However, despite important progress made in the past decades, robustness, efficiency and precision of the existing methods must still be improved to translate them into medical and engineering applications [1]. Equilibrated Warping is a novel image registration approach, based on the finite element method and the equilibrium gap regularization [2]. The finite element method is used to formulate the image registration problem, i.e., to find the displacement field that best match the source and target images, allowing to ensure some regularity to the solution. However, because of image limited resolution and noise, this problem is ill-posed, and require regularization. The equilibrium gap regularization essentially penalizes any deviation from the solution of a hyperelastic body in equilibrium with arbitrary loads prescribed at the boundary [3]. It thus represents a regularization with strong mechanical basis. In the presentation, we will first describe the consistent linearization and discretization of the regularized image correlation problem. On simple synthetic images examples, we will show that the equilibrated warping method is effective and robust: regularization strength and image noise have minimal impact on motion tracking, especially when compared to strain-based regularization methods such as hyperelastic warping, or methods based on incompressibility constraint. We will also show results of the equilibrated warping method applied to in vivo tagged (3D CSPAMM, see Figure) and untagged (CINE) cardiac magnetic resonance images of a healthy volunteer: the method allows to extract main deformation features of the left ventricle, including radial thickening, circumferential and longitudinal shortening, as well as ventricular twist. It is also able to extract finer features of deformation, such as (i) larger radial strains in the free wall compared to the septum (because of the right ventricular pressure, this is only seen in untagged images); (ii) longitudinal variations of the radial-circumferential shear strain from apex to base. Finally, we will show that equilibrated warping compares very well with other image registration methods on a public cardiac motion tracking challenge data [1].
Published: 2018

212. Regulation of initiation of follicle growth and dynamics of early follicular development in the sheep

Author: Danielle Monniaux, veronique cadoret, Frederique Clement, Stéphane Fabre, Yann Locatelli, Philippe Monget, Rozenn Dalbies-Tran, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Follicle, endocrine system, Oocyte, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Ovary, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction
Abstract: International audience; Primordial follicles embedded in the ovarian cortex are the source of developing follicles. Follicle growth activa- tion and development up to the small antral follicle stage are controlled by cell interactions. The sheep ovary offers an appropriate non-rodent model to study these interac- tions, thanks to the development of in vitro and in vivo experimental approaches, ex vivo molecular analyses and in silico mathematical modeling. Each primordial follicle, composed of an oocyte surrounded by a single layer of quiescent granulosa cells, relies on nutrients and growth factors supplied by the surrounding stroma of connective tissue. In vitro cultures of ovarian cortex have shown that primordial follicles are activated by the lifting of mech- anisms maintaining quiescence, some of them involving AMH secreted by already growing follicles. Afterwards, follicle development is supported by a finely tuned molec- ular dialog between the growing oocyte and proliferating granulosa cells. The isolation of preantral follicles and their development in vitro as individual follicles perturb this dialog, leading to an acceleration of follicular matu- ration. In vivo, mutations in the oocyte factors BMP15, GDF9 or their receptor BMPR1B also impair this dia- log, leading to an imbalance between oocyte growth and cell proliferation, which can be reproduced by models for cell dynamics. During the growth of preantral follicles, the recruitment and differentiation of theca cells from the ovarian stroma provide them with a structural and vascularized support. In vivo exposure of sheep fetal ovaries to testosterone imprints the stroma cells so that the expression of genes involved in extracellular matrix organization and cell-cell adhesion is affected in theca at adulthood; this leads to a lower ovarian tissue rigid- ity that can account for the accelerated follicle growth observed in androgenized ewes. A better knowledge of cell interactions during early follicular development will help to improve the biotechnology methods of fertility preservation.
Published: 2018

213. Convergence of discrete-time Kalman filter estimate to continuous-time estimate for systems with unbounded observation

Author: Atte Aalto, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Department of Mathematics and Systems Analysis [Helsinki], Aalto University, University of Luxembourg [Luxembourg], École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Temporal discretization, 0209 industrial biotechnology, Control and Optimization, Applied Mathematics, Infinite-dimensional systems, Boundary control systems, 02 engineering and technology, Sampled data, MSC2010: 93E11, 47D06, 93C05, 60G15, temporal discretization, sampled data, 020901 industrial engineering & automation, Control and Systems Engineering, Optimization and Control (math.OC), Signal Processing, FOS: Mathematics, Mathematics [G03] [Physical, chemical, mathematical & earth Sciences], Mathématiques [G03] [Physique, chimie, mathématiques & sciences de la terre], Kalman filter, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Mathematics - Optimization and Control
Abstract: In this article, we complement recent results on the convergence of the state estimate obtained by applying the discrete-time Kalman filter on a time-sampled continuous-time system. As the temporal discretization is refined, the estimate converges to the continuous-time estimate given by the Kalman--Bucy filter. We shall give bounds for the convergence rates for the variance of the discrepancy between these two estimates. The contribution of this article is to generalize the convergence results to systems with unbounded observation operators under different sets of assumptions, including systems with diagonaliz-able generators, systems with admissible observation operators, and systems with analytic semigroups. The proofs are based on applying the discrete-time Kalman filter on a dense, numerable subset on the time interval [0,T] and bounding the increments obtained. These bounds are obtained by studying the regularity of the underlying semigroup and the noise-free output., arXiv admin note: text overlap with arXiv:1408.1275
Published: 2018

214. Iterative observer-based state and parameter estimation for linear systems

Author: Atte Aalto, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: 0209 industrial biotechnology, Control and Optimization, Iterative method, Bilinear interpolation, 02 engineering and technology, Interval (mathematics), Fixed point, 01 natural sciences, 020901 industrial engineering & automation, Control theory, FOS: Mathematics, Parameter estimation, 0101 mathematics, MSC: 93B30, 35R30, 93C05, Mathematics - Optimization and Control, Mathematics, system identification, Estimation theory, output error minimization, Linear system, System identification, State (functional analysis), 16. Peace & justice, back and forth nudging, 010101 applied mathematics, Computational Mathematics, Optimization and Control (math.OC), Control and Systems Engineering, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], 93B30, 35R30, 93C05
Abstract: We propose an iterative method for joint state and parameter estimation using measurements on a time interval [0,T] for systems that are backward output stabilizable. Since this time interval is fixed, errors in initial state may have a big impact on the parameter estimate. We propose to use the back and forth nudging (BFN) method for estimating the system's initial state and a Gauss--Newton step between BFN iterations for estimating the system parameters. Taking advantage of results on the optimality of the BFN method, we show that for systems with skew-adjoint generators, the initial state and parameter estimate minimizing an output error cost functional is an attractive fixed point for the proposed method. We treat both linear source estimation and bilinear parameter estimation problems., Manuscript submitted for publication
Published: 2018

215. Efficient estimation of personalized biventricular mechanical function employing gradient‐based optimization

Author: Finsberg, Henrik, Xi, Ce, Tan, Ju Le, Zhong, Liang, Genet, Martin, Sundnes, Joakim, Lee, Lik Chuan, Wall, Samuel T., University of Oslo (UiO), Michigan State University [East Lansing], Michigan State University System, National Heart Centre Singapore (NHCS), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Norwegian University of Life Sciences (NMBU), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Systole, Heart Ventricles, [INFO.INFO-CE]Computer Science [cs]/Computational Engineering, Finance, and Science [cs.CE], Finite Element Analysis, Models, Cardiovascular, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Reproducibility of Results, Part B ‐ Applications, stress estimation, Magnetic Resonance Imaging, cardiac mechanics, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diastole, contractility estimation, Humans, Ventricular Function, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Stress, Mechanical, parameter estimation, data assimilation, patient specific simulations, Research Article ‐ Application
Abstract: International audience; Individually personalized computational models of heart mechanics can be used to estimate important physiological and clinically-relevant quantities that are difficult, if not impossible, to directly measure in the beating heart. Here, we present a novel and efficient framework for creating patient-specific biventricular models using a gradient-based data assimilation method for evaluating regional myocardial contractility and estimating myofiber stress. These simulations can be performed on a regular laptop in less than 2 h and produce excellent fit between measured and simulated volume and strain data through the entire cardiac cycle. By applying the framework using data obtained from 3 healthy human biventricles, we extracted clinically important quantities as well as explored the role of fiber angles on heart function. Our results show that steep fiber angles at the endocardium and epicardium are required to produce simulated motion compatible with measured strain and volume data. We also find that the contraction and subsequent systolic stresses in the right ventricle are significantly lower than that in the left ventricle. Variability of the estimated quantities with respect to both patient data and modeling choices are also found to be low. Because of its high efficiency, this framework may be applicable to modeling of patient specific cardiac mechanics for diagnostic purposes.
Published: 2018

216. Characterization of oxide scales formed on alloy 82 in nominal PWR primary water at 340 °C and in hydrogenated steam at 400 °C

Author: Catherine Guerre, I. de Curieres, Mohamed Sennour, Jérôme Crépin, Cecilie Duhamel, Eva Héripré, E. Chaumun, F. Georgi, Centre des Matériaux (CDM), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre de Mise en Forme des Matériaux (CEMEF), Laboratoire d'Etude de la Corrosion Aqueuse (LECA), Service de la Corrosion et du Comportement des Matériaux dans leur Environnement (SCCME), Département de Physico-Chimie (DPC), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département de Physico-Chimie (DPC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, MINES ParisTech, PSL Research University, MAT - Centre des matériaux, CNRS UMR 7633, BP 87, 91003 Evry Cedex, France, MINES ParisTech, PSL Research University, CEMEF - Centre de mise en forme des matériaux, CNRS UMR 7635, CS 10207 rue Claude Daunesse, 06904 Sophia-Antipolis, CEA, DEN, DPC, SCCME, Laboratoire d’Etude de la Corrosion Aqueuse, F-91191 Gif-sur-Yvette, France, Ecole Polytechnique, Laboratoire de Mécanique des Solides, CNRS UMR 7649, 91128 Palaiseau Cedex, France, and Institute for Radiological Protection and Nuclear Safety (IRSN), DSR/SAMS, BP17, 92262 Fontenay-aux-Roses Cedex, France
Subjects: Materials science, Scanning electron microscope, General Chemical Engineering, Alloy 82, Alloy, Passive film, Oxide, chemistry.chemical_element, 02 engineering and technology, engineering.material, 01 natural sciences, 7. Clean energy, complex mixtures, law.invention, Corrosion, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, X-ray photoelectron spectroscopy, law, Nickel, 0103 physical sciences, XPS, General Materials Science, Welding, 010302 applied physics, Pressurized water reactor, technology, industry, and agriculture, General Chemistry, 021001 nanoscience & nanotechnology, equipment and supplies, chemistry, Chemical engineering, [SDU]Sciences of the Universe [physics], Transmission electron microscopy, engineering, TEM, 0210 nano-technology
Abstract: International audience; Alloy 82, used as weld metal in Pressurized Water Reactor (PWR), was exposed to hydrogenated steam at 400 °C and to simulated primary water at 340 °C. A comparative study of the oxide layer formed on the alloy surface in both environments was performed to confirm that steam conditions were representative of accelerated primary water conditions. For this purpose, the oxidation products were investigated at a nanometer scale using Scanning Electron Microscopy (SEM), X-ray Photoelectron Spectrometry (XPS) and Transmission Electron Microscopy (TEM). Results obtained in both conditions are compared and the influences of heat treatment, test duration and surface preparation are studied.
Published: 2018

217. Airborne ultrasound surface motion camera: application to seismocardiography

Author: Pavel Shirkovskiy, R.K. Ing, Dominique Chapelle, Mathias Fink, Nathan Jeger-Madiot, Alexandre Laurin, Institut Langevin - Ondes et Images (UMR7587) (IL), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Synthetic aperture radar, Physics and Astronomy (miscellaneous), Computer science, Wave propagation, Acoustics, non-contact seismocardiography, 030204 cardiovascular system & hematology, Accelerometer, 01 natural sciences, cardiac mechanics, 03 medical and health sciences, Acceleration, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Position (vector), [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Center frequency, surface motion, business.industry, 010401 analytical chemistry, Ultrasound, airborne ultrasound vibrometry, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], cardio-vascular signals, Non-contact ultrasonic imaging, 0104 chemical sciences, Identifiability, business
Abstract: International audience; The recent achievements in the accelerometer-based seismocardiography field indicate a strong potential for this technique to address wide variety of clinical needs. Recordings from different locations on the chest can give a more comprehensive observation and interpretation of wave propagation phenomena than a single-point recording, can validate existing modeling assumptions (such as the representation of the sternum as a single solid body), and provide better identifiability for models using richer recordings. Ultimately, the goal is to advance our physiological understanding of the processes to provide useful data to promote cardiovascular health. Accelerometer-based multichannel system is a contact method and laborious for use in practice, also even ultralight accelerometers can cause non-negligible loading effects. We propose a new contactless ultrasound imaging method to measure thoracic and abdominal surface motions, demonstrating that it is adequate for typical seismocardiogram use. The developed method extends non-contact surface-vibrometry to fast 2D mapping by originally combining multi-element airborne ultrasound arrays, a synthetic aperture implementation and pulsed-waves. Experimental results show the ability of the developed method to obtain 2D seismocardiographic maps of the body surface 30×40 cm 2 in dimension, with a temporal sampling rate of several hundred Hz, using ultrasound waves with the central frequency of 40 kHz. Our implementation was validated in-vivo on eight healthy human participants. The shape and position of the zone of maximal absolute acceleration and velocity during the cardiac cycle were also observed. This technology could potentially be used to obtain more complete cardio-vascular information than single-source SCG in and out of clinical environments, due to enhanced identifiability provided by distributed measurements, and observation of propagation phenomena.
Published: 2018

218. Equilibrated warping: Finite element image registration with finite strain equilibrium gap regularization

Author: Lik Chuan Lee, Christian T. Stoeck, C von Deuster, Sebastian Kozerke, Martin Genet, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Michigan State University [East Lansing], Michigan State University System, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), University of Zurich, and Genet, M
Subjects: 1707 Computer Vision and Pattern Recognition, Discretization, Computer science, Computer Graphics and Computer, Finite Element Analysis, Finite elements, Image registration, 610 Medicine & health, Health Informatics, 030204 cardiovascular system & hematology, 1704 Computer Graphics and Computer-Aided Design, Regularization (mathematics), 030218 nuclear medicine & medical imaging, 170 Ethics, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Linearization, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, 2741 Radiology, Nuclear Medicine and Imaging, 10237 Institute of Biomedical Engineering, Radiology, Nuclear Medicine and imaging, Aided Design, Image warping, 3614 Radiological and Ultrasound Technology, Cardiac magnetic resonance imaging, 2718 Health Informatics, Radiological and Ultrasound Technology, Mathematical analysis, Heart, Magnetic Resonance Imaging, Computer Graphics and Computer-Aided Design, Finite element method, Radiology Nuclear Medicine and imaging, Finite strain theory, Hyperelastic material, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Computer Vision and Pattern Recognition, Equilibrium gap regularization
Abstract: International audience; In this paper, we propose a novel continuum finite strain formulation of the equilibrium gap regularization for image registration. The equilibrium gap regularization essentially penalizes any deviation from the solution of a hyperelastic body in equilibrium with arbitrary loads prescribed at the boundary. It thus represents a regularization with strong mechanical basis, especially suited for cardiac image analysis. We describe the consistent linearization and discretization of the regularized image registration problem, in the framework of the finite elements method. The method is implemented using FEniCS & VTK, and distributed as a freely available python library. We show that the equilibrated warping method is effective and robust: regularization strength and image noise have minimal impact on motion tracking, especially when compared to strain-based regularization methods such as hyperelastic warping. We also show that equilibrated warping is able to extract main deformation features on both tagged and untagged cardiac magnetic resonance images.
Published: 2018

219. Front shape similarity measure for shape-oriented sensitivity analysis and data assimilation for Eikonal equation

Author: Annabelle Collin, Cong Zhang, Arnaud Trouvé, Philippe Moireau, Mélanie C. Rochoux, Didier Lucor, Centre Européen de Recherche et de Formation Avancée en Calcul Scientifique (CERFACS), Modélisation Mathématique pour l'Oncologie (MONC), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Department of Fire Protection Engineering [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris-Sud - Paris 11 (UP11)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Saclay (COmUE), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, CERFACS [Toulouse], Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux], École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris Saclay (COmUE)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France
Subjects: Computer science, 0211 other engineering and technologies, 02 engineering and technology, Similarity measure, computer.software_genre, Measure (mathematics), Data assimilation, ACM: I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION/I.4.7: Feature Measurement/I.4.7.4: Size and shape, QA1-939, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Physics::Atmospheric and Oceanic Physics, ACM: G.: Mathematics of Computing/G.1: NUMERICAL ANALYSIS/G.1.8: Partial Differential Equations/G.1.8.5: Hyperbolic equations, 040101 forestry, T57-57.97, 021110 strategic, defence & security studies, Applied mathematics. Quantitative methods, Polynomial chaos, Estimation theory, Eikonal equation, 04 agricultural and veterinary sciences, Kalman filter, ACM: G.: Mathematics of Computing/G.1: NUMERICAL ANALYSIS/G.1.8: Partial Differential Equations/G.1.8.6: Inverse problems, ACM: I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION/I.4.6: Segmentation/I.4.6.0: Edge and feature detection, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Wildfire modeling, 0401 agriculture, forestry, and fisheries, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], computer, Algorithm, Mathematics
Abstract: International audience; We present a shape-oriented data assimilation strategy suitable for front-tracking problems through the example of wildfire. The concept of " front " is used to model, at regional scales, the burning area delimitation that moves, undergoes shape and topological changes under heterogeneous orography, biomass fuel and micrometeorology. The simulation-observation discrepancies are represented using a front shape similarity measure deriving from image processing and based on the Chan-Vese contour fitting functional. We show that consistent corrections of the front location and uncertain physical parameters can be obtained using this measure applied on a level-set fire growth model solving for an eikonal equation. This study involves a Luenberger observer for state estimation, including a topological gradient term to track multiple fronts, and of a reduced-order Kalman filter for joint parameter estimation. We also highlight the need – prior to parameter estimation – for sensitivity analysis based on the same discrepancy measure, and for instance using polynomial chaos metamodels, to ensure a meaningful inverse solution is achieved. The performance of the shape-oriented data assimilation strategy is assessed on a synthetic configuration subject to uncertainties in front initial position, near-surface wind magnitude and direction. The use of a robust front shape similarity measure paves the way toward the direct assimilation of infrared images and is a valuable asset in the perspective of data-driven wildfire modeling.
Published: 2018

220. Solving 2D linear isotropic elastodynamics by means of scalar potentials: a new challenge for finite elements

Author: Patrick Joly, Jerónimo Rodríguez, Sébastien Imperiale, Jorge Martínez, Departamento de Matemática Aplicada, Universidade de Santiago de Compostela [Spain] (USC ), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, Propagation des Ondes : Étude Mathématique et Simulation (POEMS), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Unité de Mathématiques Appliquées (UMA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS), Universidade de Santiago de Compostela, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine ( M3DISIM ), Laboratoire de mécanique des solides ( LMS ), École polytechnique ( X ) -MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique ( CNRS ) -École polytechnique ( X ) -MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique ( CNRS ) -Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Propagation des Ondes : Étude Mathématique et Simulation ( POEMS ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Unité de Mathématiques Appliquées ( UMA ), École Nationale Supérieure de Techniques Avancées ( Univ. Paris-Saclay, ENSTA ParisTech ) -École Nationale Supérieure de Techniques Avancées ( Univ. Paris-Saclay, ENSTA ParisTech ) -Centre National de la Recherche Scientifique ( CNRS ), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: Numerical Analysis, Applied Mathematics, Isotropy, Scalar (mathematics), Mathematical analysis, General Engineering, 010103 numerical & computational mathematics, [ MATH.MATH-NA ] Mathematics [math]/Numerical Analysis [math.NA], 01 natural sciences, Finite element method, Theoretical Computer Science, 010101 applied mathematics, Computational Mathematics, [ MATH.MATH-AP ] Mathematics [math]/Analysis of PDEs [math.AP], Computational Theory and Mathematics, Displacement field, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Boundary value problem, Time domain, 0101 mathematics, Scalar field, Helmholtz decomposition, Software, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Mathematics
Abstract: International audience; In this work we present a method for the computation of numerical solutions of 2D homogeneous isotropic elastodynamics equations by solving scalar wave equations. These equations act on the potentials of a Helmholtz decomposition of the displacement field and are decoupled inside the propagation domain. We detail how these equations are coupled at the boundary depending on the nature of the boundary condition satisfied by the displacement field. After presenting the case of rigid boundary conditions, that presents no specific difficulty, we tackle the challenging case of free surface boundary conditions that presents severe stability issues if a straightforward approach is used. We introduce an adequate functional framework as well as a time domain mixed formulation to circumvent these issues. Numerical results confirm the stability of the proposed approach.
Published: 2018

221. Energy decay and stability of a perfectly matched layer for the wave equation

Author: Maryna Kachanovska, Sébastien Imperiale, Daniel H. Baffet, Marcus J. Grote, Department of Mathematics [Basel], University of Basel (Unibas), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut Polytechnique de Paris (IP Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Propagation des Ondes : Étude Mathématique et Simulation (POEMS), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Unité de Mathématiques Appliquées (UMA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-0056,LMH,LabEx Mathématique Hadamard(2011), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Numerical Analysis, Wave propagation, Applied Mathematics, Mathematical analysis, General Engineering, 010103 numerical & computational mathematics, Space (mathematics), Wave equation, 01 natural sciences, Stability (probability), Theoretical Computer Science, 010101 applied mathematics, Computational Mathematics, Perfectly matched layer, Computational Theory and Mathematics, Preprint, 0101 mathematics, [MATH]Mathematics [math], Constant (mathematics), Software, Energy (signal processing), [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Mathematics
Abstract: In Grote and Sim (Efficient PML for the wave equation. Preprint, arXiv:1001.0319 [math:NA], 2010; in: Proceedings of the ninth international conference on numerical aspects of wave propagation (WAVES 2009, held in Pau, France, 2009), pp 370–371), a PML formulation was proposed for the wave equation in its standard second-order form. Here, energy decay and $$L^2$$ stability bounds in two and three space dimensions are rigorously proved both for continuous and discrete formulations with constant damping coefficients. Numerical results validate the theory.
Published: 2018
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222. Newton-Krylov method for computing the cyclic steady states of evolution problems in non-linear mechanics

Author: Khristenko, Ustim, Le Tallec, Patrick, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Computer Science::Mathematical Software, [SPI.MECA.MSMECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], Computer Science::Numerical Analysis
Abstract: International audience; This work is focused on the Newton‐Krylov technique for computing the steady cyclic states of evolution problems in non‐linear mechanics with space‐time periodicity conditions. This kind of problems can be faced, for instance, in the modeling of a rolling tyre with a periodic tread pattern, where the cyclic state satisfies "rolling" periodicity condition, including shifts both in time and space.The Newton‐Krylov method is a combination of a Newton nonlinear solver with a Krylov linear solver, looking for the initial state, which provides the space‐time periodic solution. The convergence of the Krylov iterations is proved to hold in presence of an adequate preconditioner. After preconditioning, the Newton‐Krylov method can be also considered as an observer‐controller method, correcting the transient solution of the initial value problem after each period. Using information stored while computing the residual, the Krylov solver computation time becomes negligible with respect to the residual computation time.The method has been analyzed and tested on academic applications and compared to the standard evolution (fixed point) method. Finally, it has been implemented into the Michelin industrial code, applied to a full 3D rolling tyre model.
Published: 2018

223. A conservative penalisation strategy for the semi-implicit time discretisation of incompressible elastodynamics equation

Author: Caforio, Federica, Imperiale, Sébastien, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: Time discretisation, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Elastodynamic equations, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Incompressibility
Abstract: International audience; The principal aim of this work is to provide an adapted numerical scheme for the approximation of elastic wave propagation in incompressible solids. We rely on high-order conforming finite element with mass lumping for space discretisation and implicit/explicit, second-order, energy-preserving time discretisation. The time step restriction only depends on the shear wave velocity and at each time step a Poisson problem must be solved to account for the incompressibility constraint that is imposed by penalisation techniques.
Published: 2018

224. The importance of the pericardium for cardiac biomechanics: From physiology to computational modeling

Author: Martin R. Pfaller, Radomir Chabiniok, Wolfgang A. Wall, Andreas Nagler, Julia M. Hörmann, Cristóbal Bertoglio, Martina Weigl, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Université Paris-Saclay, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Bernoulli Institute for Mathematics for Mathematics, Computer Science and Artificial Intelligence Groningen, University of Groningen [Groningen], École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Computational and Numerical Mathematics
Subjects: FOS: Computer and information sciences, 02 engineering and technology, 030204 cardiovascular system & hematology, Computational Engineering, Finance, and Science (cs.CE), Cardiac mechanical modeling, 0302 clinical medicine, Pericardium, PASSIVE MYOCARDIUM, Computer Science - Computational Engineering, Finance, and Science, SOLE MECHANISM, Models, Cardiovascular, Pericardial cavity, Mechanics, MECHANICAL-PROPERTIES, VENTRICULAR MECHANICS, Magnetic Resonance Imaging, Biomechanical Phenomena, medicine.anatomical_structure, HEARTH, Modeling and Simulation, Heart Function Tests, cardiovascular system, Finite element simulation, Biotechnology, Materials science, Systole, Finite Element Analysis, 0206 medical engineering, ATRIOVENTRICULAR PLANE DISPLACEMENT, FOS: Physical sciences, PRESSURE, Dashpot, 03 medical and health sciences, Imaging, Three-Dimensional, Approximation error, ATRIAL, medicine, Humans, Computer Simulation, Boundary value problem, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Boundary conditions, Plane (geometry), Mechanical Engineering, QUANTIFICATION, 020601 biomedical engineering, Physics - Medical Physics, Medical Physics (physics.med-ph), Stress, Mechanical, ORIENTATION, Displacement (fluid), Normal
Abstract: International audience; The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and friction-less sliding of the myocardium. The influence of the pericardium is essential for predictive mechanical simulations of the heart. However, there is no consensus on physiologically correct and computationally tractable pericardial boundary conditions. Here we propose to model the pericardial influence as a parallel spring and dashpot acting in normal direction to the epicardium. Using a four-chamber geometry, we compare a model with pericardial boundary conditions to a model with fixated apex. The influence of pericardial stiffness is demonstrated in a parametric study. Comparing simu-lation results to measurements from cine magnetic resonance imaging reveals that adding pericardial boundary conditions yields a better approximation with respectto atrioventricular plane displacement, atrial filling, and overall spatial approximation error. We demonstrate that this simple model of pericardial-myocardial interaction can correctly predict the pumping mechanisms ofthe heart as previously assessed in clinical studies. Utilizing a pericardial model can not only provide much more realistic cardiac mechanics simulations but also allows new insights into pericardial-myocardial interaction which cannot be assessed in clinical measurement.
Published: 2018

225. Mathematical analysis and 2-scale convergence of a heterogeneous microscopic bidomain model

Author: Annabelle Collin, Sébastien Imperiale, Modélisation Mathématique pour l'Oncologie (MONC), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Université Paris-Saclay, Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux], École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Nondimensionalization, Applied Mathematics, Quantitative Biology::Tissues and Organs, 010102 general mathematics, Mathematical analysis, Bidomain model, 01 natural sciences, Homogenization (chemistry), 010101 applied mathematics, [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], Modeling and Simulation, Symbolic convergence theory, 0101 mathematics, Mathematics
Abstract: International audience; The aim of this paper is to provide a complete mathematical analysis of the periodic homogenization procedure that leads to the macroscopic bidomain model in cardiac elec-trophysiology. We consider space-dependent and tensorial electric conductivities as well as space-dependent physiological and phenomenological non-linear ionic models. We provide the nondimensionalization of the bidomain equations and derive uniform estimates of the solutions. The homogenization procedure is done using 2-scale convergence theory which enables us to study the behavior of the non-linear ionic models in the homogenization process .
Published: 2018

226. An adaptive Hybridizable Discontinuous Galerkin approach for cardiac electrophysiology

Author: Hoermann, Julia M., Bertoglio, Cristóbal, Kronbichler, Martin, Pfaller, Martin R., Chabiniok, Radomir, Wall, Wolfgang A., Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), University of Groningen [Groningen], Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Université Paris-Saclay, Institute for Computational Mechanics, Technical University of Munich, Garching, Germany, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: finite element method, Hybridizable Discontinuous Galerkin, [SDV.IB]Life Sciences [q-bio]/Bioengineering, cardiac electrophysiology, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: International audience; Cardiac electrophysiology simulations are numerically challenging due to the propagation of a steep electrochemical wave front and thus require discretizations with small mesh sizes to obtain accurate results. In this work, we present an approach based on the Hybridizable Discontinuous Galerkin method (HDG), which allows an efficient implementation of high-order discretizations into a computational framework. In particular using the advantage of the discontinuous function space, we present an efficient p-adaptive strategy for accurately tracking the wave front. HDG allows to reduce the overall degrees of freedom in the final linear system to those only on the element interfaces. Additionally, we propose a rule for a suitable integration accuracy for the ionic current term depending on the polynomial order and the cell model to handle high-order polynomials. Our results show that for the same number of degrees of freedom coarse high-order elements provide more accurate results than fine low-order elements. Introducing p-adaptivity further reduces computational costs while maintaining accuracy by restricting the use of high-order elements to resolve the wave front. For a patient-specific simulation of a cardiac cycle p-adaptivity reduces the average number of degrees of freedom by 95% compared to the non-adaptive model. In addition to reducing computational costs, using coarse meshes with our p-adaptive high-order HDG method also simplifies practical aspects of mesh generation and postprocessing.
Published: 2018

227. Extra Corporeal Life Support for Cardiac ARrest patients with post-cardiac arrest syndrome: the ECCAR study

Author: Bouglé, Adrien, Le Gall, Arthur, Dumas, Florence, Geri, Guillaume, Malissin, Isabelle, Voicu, Sebastian, Mégarbane, Bruno, Cariou, Alain, Deye, Nicolas, Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie - Immunopathologie - Immunothérapeutique (I3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Soins Intensifs [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Service d'anesthésiologie et soins intensifs [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Lariboisière-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: endocrine system, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract: International audience; Purpose: Post-Cardiac Arrest Shock (PCAS) occurring after resuscitated cardiac arrest (CA), is a main cause of early death. Extra-Corporeal Life Support (ECLS) could be useful pending recovery of myocardial failure. We aimed to describe our PCAS population, and factors associated with ECLS initiation. Materials and Methods: This analysis included 924 patients admitted in two intensive care units (ICU) between 2005 and 2014 for CA and PCAS, and, of those patients, 43 patients for whom an ECLS was initiated. Neurological and ECLS-related outcomes were gathered retrospectively. Results: The 43 ECLS patients were predominantly young males with evidence of myocardial infarction on coronary angiography (70%). ECLS was initiated in patients suffering from severe cardiovascular dysfunction (Left Ventricular Ejection Fraction: 15 [10 -25] %), with a median delay of 9 [6 -16] hours following CA. At one year, 8 patients survived (19%) without neurological disability. Blood lactate and coronary etiology were associated with neurological outcomes. Logistic regression conducted using 878 PCAS controls identified age, sex, current smoking, location of CA, blood lactate and creatinine levels as risk factors for initiation of ECLS.Conclusions: ECLS, as a salvage therapy for PCAS, could represent an acceptable alternative for highly selected patients.
Published: 2018

228. 126 Regulation of initiation of follicle growth and dynamics of early follicular development in the sheep

Author: Yann Locatelli, Philippe Monget, Frédérique Clément, Danielle Monniaux, Rozenn Dalbies-Tran, V. Cadoret, Stéphane Fabre, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), and Université de Toulouse (UT)-Université de Toulouse (UT)
Subjects: endocrine system, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Ovarian Cortex, General Medicine, Biology, Oocyte, Antral follicle, follicle, Cell biology, Abstracts, Follicle, medicine.anatomical_structure, Theca, Follicular phase, Genetics, medicine, Animal Science and Zoology, ovary, Folliculogenesis, oocyte, Food Science, Extracellular matrix organization
Abstract: Notice à reprendre pas de clé UT au 14 Janvier 2018; International audience; Primordial follicles embedded in the ovarian cortex are the source of developing follicles. Follicle growth activationand development up to the small antral follicle stage are controlled by cell interactions. The sheep ovary offersan appropriate non-rodent model to study these interactions, thanks to the development of in vitro and in vivoexperimental approaches, ex vivo molecular analyses and in silico mathematical modeling. Each primordial follicle, composed of an oocyte surrounded by a single layer of quiescent granulosa cells, relies on nutrients and growth factors supplied by the surrounding stroma of connective tissue. In vitro cultures of ovarian cortex have shown that primordial follicles are activated by the lifting of mechanisms maintaining quiescence, some of them involving AMH secreted by already growing follicles. Afterwards, follicle development is supported by a finely tuned molecular dialog between the growing oocyte and proliferating granulosa cells. The isolation of preantral follicles and their development in vitro as individual follicles perturb this dialog, leading to an acceleration of follicular maturation. In vivo, mutations in the oocyte factors BMP15, GDF9 or their receptor BMPR1B also impair this dialog, leading to an imbalance between oocyte growth and cell proliferation, which can be reproduced by models for cell dynamics. During the growth of preantral follicles, the recruitment and differentiation of theca cells from the ovarian stroma provide them with a structural and vascularized support. In vivo exposure of sheep fetalovaries to testosterone imprints the stroma cells so that the expression of genes involved in extracellular matrixorganization and cell-cell adhesion is affected in theca at adulthood; this leads to a lower ovarian tissue rigiditythat can account for the accelerated follicle growth observed in androgenized ewes. A better knowledge ofcell interactions during early follicular development will help to improve the biotechnology methods of fertilitypreservation.
Published: 2018

229. Validation of cardiac strain estimation from 3D-tagged magnetic resonance images using finite element image correlation

Author: Berberoglu, Ezgi, Stoeck, Christian, Kozerke, Sebastian, Genet, Martin, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institute for Biomedical Engineering [ETH Zürich] (IBT), Universität Zürich [Zürich] = University of Zurich (UZH)-Department of Information Technology and Electrical Engineering [Zürich] (D-ITET), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

230. Groundwater flow and heat transport for systems undergoing freeze-thaw : Intercomparison of numerical simulators for 2D test cases

Author: N. Collier, Andrew Frampton, Agnès Rivière, Johann Holmén, Emmanuel Mouche, John Molson, Barret L. Kurylyk, Ethan T. Coon, Jennifer M. Frederick, René Therrien, Patrik Vidstrand, Jan Olof Selroos, Clifford I. Voss, Romain Pannetier, Nicolas Roux, Christophe Grenier, Quentin Chanzy, Laurent Orgogozo, Samuel Kokh, Johanna Scheidegger, H. Anbergen, François Costard, Wolfram Rühaak, Victor F. Bense, Michel Ferry, Julio Gonçalvès, Anne Jost, Jeffrey M. McKenzie, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Modélisation Hydrologique (HYDRO), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), APS Antriebs-, Prüf- und Steuertechnik GmbH, School of Environmental Sciences [Norwich], University of East Anglia [Norwich] (UEA), ENS Cachan, Département Génie Mécanique, Université Paris-Saclay, Cachan, France, Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Climate Change Science Institute [Oak Ridge] (CCSI), UT-Battelle, LLC-UT-Battelle, LLC, Géosciences Paris Sud (GEOPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), MFRDC, 6 rue de la Perche 44700 Orvault, France, Department of Physical Geography and Quaternary Geology, Stockholm University, Division of Hydrologic Sciences, Desert Research Institute (DRI), Structure et fonctionnement des systèmes hydriques continentaux (SISYPHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Golder Associates Kapellgränd 7, 11625 Stockholm, Sweden, Laboratoire d'Etudes Thermiques des Réacteurs (LETR), Département de Modélisation des Systèmes et Structures (DM2S), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre dor Water Resources Studies [Halifax] (CWRS), Dalhousie University [Halifax], Department of Civil and Resource Engineering [Halifax], Department of Earth and Planetary Sciences [Montréal] (EPS), McGill University = Université McGill [Montréal, Canada], Université Laval [Québec] (ULaval), Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Géosciences (GEOSCIENCES), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Technische Universität Darmstadt - Technical University of Darmstadt (TU Darmstadt), British Geological Survey (BGS), Swedish Nuclear Fuel and Waste Management Company, United States Geological Survey [Reston] (USGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-MINES ParisTech - École nationale supérieure des mines de Paris, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), MINES ParisTech - École nationale supérieure des mines de Paris, and TU Darmstadt Graduate School of Excellence Energy Science & Engineering
Subjects: 010504 meteorology & atmospheric sciences, Groundwater flow, Discretization, 0208 environmental biotechnology, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Permafrost, 02 engineering and technology, Numerical simulation, Hydrology and Quantitative Water Management, 01 natural sciences, Sharp interface problems, Range (statistics), ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Water Science and Technology, WIMEK, Computer simulation, Thermo-hydrological coupling, Mechanics, 020801 environmental engineering, Test case, Code benchmarking, 13. Climate action, [SDU]Sciences of the Universe [physics], Environmental science, Temporal discretization, Groundwater, Hydrologie en Kwantitatief Waterbeheer
Abstract: In high-elevation, boreal and arctic regions, hydrological processes and associated water bodies can be strongly influenced by the distribution of permafrost. Recent field and modeling studies indicate that a fully-coupled multidimensional thermo-hydraulic approach is required to accurately model the evolution of these permafrost-impacted landscapes and groundwater systems. However, the relatively new and complex numerical codes being developed for coupled non-linear freeze-thaw systems require verification. This issue is addressed by means of an intercomparison of thirteen numerical codes for two-dimensional test cases with several performance metrics (PMs). These codes comprise a wide range of numerical approaches, spatial and temporal discretization strategies, and computational efficiencies. Results suggest that the codes provide robust results for the test cases considered and that minor discrepancies are explained by computational precision. However, larger discrepancies are observed for some PMs resulting from differences in the governing equations, discretization issues, or in the freezing curve used by some codes.
Published: 2018

231. Turbulent route to two-dimensional soft crystals

Author: Mohit Gupta, Pinaki Chaudhuri, Jérémie Bec, Samriddhi Sankar Ray, Centre de Mise en Forme des Matériaux (CEMEF), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Stochastic Approaches for Complex Flows and Environment (CALISTO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), International Centre for Theoretical Sciences [TIFR] (ICTS-TIFR), Tata Institute for Fundamental Research (TIFR), and MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: [PHYS.PHYS.PHYS-FLU-DYN]Physics [physics]/Physics [physics]/Fluid Dynamics [physics.flu-dyn], Condensed Matter::Soft Condensed Matter, Physics::Fluid Dynamics, Fluid Dynamics (physics.flu-dyn), Soft Condensed Matter (cond-mat.soft), FOS: Physical sciences, Physics - Fluid Dynamics, Condensed Matter - Soft Condensed Matter, Chaotic Dynamics (nlin.CD), Nonlinear Sciences - Chaotic Dynamics
Abstract: We investigate the effects of a two-dimensional, incompressible, turbulent flow on mono-disperse soft granular particles and show the emergence of a crystalline phase due to the interplay of Stokesian drag (measured through the Stokes number) and short-range inter-particle interactions. We quantify this phase through the bond order parameter and local density fluctuations and find a sharp transition between the crystalline and non-crystalline phase as a function of the Stokes number. Furthermore, the nature of preferential concentration, as characterised by the radial distribution function and the correlation dimension $D_2$, is significantly different from that of particle-laden flows in the absence of repulsive potentials., Comment: 5 pages, 4 figures
Published: 2018
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232. Magnetic Resonance Imaging of the Heart and Large Vessels -- Survey of methods and new perspectives

Author: Chabiniok, Radomir, Súkupová, Lucie, Kautznerová, Dana, Tintěra, Jaroslav, Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, and Institute for Clinical and Experimental Medicine (IKEM)
Subjects: heart diseases, vrozené vady srdce, magnetic, Kardio MR zobrazování, srdce, heart, vrozené vady sr, magnetic resonance examination of heart, congenital heart diseases, získané vady srdce, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, acquired heart diseases, vyšetření srdce magnetickou rezonancí, acquired, cardiovascular system, cardiac MRI, cardiovascular diseases, resonance examination of heart
Abstract: International audience; Early cardiac magnetic resonance imaging (CMR) scans were of inferior quality. A sig- ni cant improvement in image quality was achieved a er introducing the segmented acquisition of the k-space synchronized with patient’s ECG, performed either in breath hold or free breathing. CMR is now used widely in the clinical setting for assessment of cardiac chamber volumes, global and regional cardiac contraction, morphology and tissue charac- terization. In ammatory or post- myocardial infarction changes involve sequences which can appreciate myocardial edema or the use of late post-gadolinium contrast enhancement (LGE) to visualise di use or focal scar. Other applications include the assessment of valvular stenosis or regurgitation by means of ow me- asurement through a de ned ori ce and rst pass myocardial perfusion to assess ischemia. Last but not least, CMR is increasingly used for the assessment of congenital heart diseases, in which CMR o ers objective and directly com- parable measures during serial examinations, without any radiation exposure.
Published: 2017

233. Coupled variational formulations of linear elasticity and the DPG methodology

Author: Brendan Keith, Federico Fuentes, Leszek Demkowicz, Patrick Le Tallec, Institute for Computational Engineering and Sciences [Austin] (ICES), University of Texas at Austin [Austin], Instituto Venezolano de Investigaciones Cientificas (IVIC), Université Paris-Saclay, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Numerical Analysis, Work (thermodynamics), Physics and Astronomy (miscellaneous), Applied Mathematics, Linear elasticity, Mathematical analysis, Mode (statistics), 65N12, 65N30, 010103 numerical & computational mathematics, Numerical Analysis (math.NA), [SPI.MECA.MSMECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], 01 natural sciences, Stability (probability), Finite element method, Domain (mathematical analysis), Computer Science Applications, 010101 applied mathematics, Computational Mathematics, Modeling and Simulation, Convergence (routing), FOS: Mathematics, Mathematics - Numerical Analysis, 0101 mathematics, Variety (universal algebra), Mathematics
Abstract: This article presents a general approach akin to domain-decomposition methods to solve a single linear PDE, but where each subdomain of a partitioned domain is associated to a distinct variational formulation coming from a mutually well-posed family of broken variational formulations of the original PDE. It can be exploited to solve challenging problems in a variety of physical scenarios where stability or a particular mode of convergence is desired in a part of the domain. The linear elasticity equations are solved in this work, but the approach can be applied to other equations as well. The broken variational formulations, which are essentially extensions of more standard formulations, are characterized by the presence of mesh-dependent broken test spaces and interface trial variables at the boundaries of the elements of the mesh. This allows necessary information to be naturally transmitted between adjacent subdomains, resulting in coupled variational formulations which are then proved to be globally well-posed. They are solved numerically using the DPG methodology, which is especially crafted to produce stable discretizations of broken formulations. Finally, expected convergence rates are verified in two different and illustrative examples., Comment: 24 pages, 5 figures
Published: 2017

234. Controllability of Parabolic Equations by the Flatness Approach

Author: Philippe Martin, Lionel Rosier, Pierre Rouchon, Centre Automatique et Systèmes (CAS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre de Robotique (CAOR), QUANTum Information Circuits (QUANTIC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), MINES ParisTech - École nationale supérieure des mines de Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-MINES ParisTech - École nationale supérieure des mines de Paris, Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: 0209 industrial biotechnology, Flatness (systems theory), 010102 general mathematics, Mathematical analysis, Degenerate energy levels, 02 engineering and technology, 16. Peace & justice, 01 natural sciences, Parabolic partial differential equation, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Controllability, 020901 industrial engineering & automation, Principal part, Heat equation, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], 0101 mathematics, Mathematics
Abstract: International audience; — We consider linear one-dimensional parabolic equations with space dependent coefficients that are only measurable and that may be degenerate or singular. We prove the null controllability with one boundary control by following the flatness approach, which provides explicitly the control and the associated trajectory as series. As an application, we consider the heat equation with a discontinuous coefficient in the principal part. The note ends with a numerical experiment which demonstrates the effectiveness of the method.
Published: 2017

235. L’intégration des enjeux de la logique de parcours dans les politiques publiques en santé : une lecture au prisme des régimes de gouvernementalité

Author: Aubert, Isabelle, Kletz, Frédéric, Sardas, Jean-Claude, Lille University Management Lab - ULR 4999 (LUMEN), Université de Lille, Centre de Gestion Scientifique i3 (CGS i3), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut interdisciplinaire de l’innovation (I3), and Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Economics, Econometrics and Finance, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2023

236. Prognosis and chemosensitivity of non-colorectal alimentary tract cancers with microsatellite instability

Author: Claire Boyer, David Sefrioui, Romain Cohen, Romain Chautard, Marine Perrier, Hugo Lebrun, Gael Goujon, Vincent Hautefeuille, Marie Dior, Thomas Walter, Florence Mary, Silvain Manfredi, Francois-Xavier Caroli-Bosc, Baptiste Cervantes, Romain Coriat, Elise Deluche, Aziz Zaanan, Raphael Olivier, Olivier Bouché, Guillaume Piessen, Thierry Lecomte, Christophe Louvet, Pierre Michel, Thomas Aparicio, Thierry André, Julien Taieb, Violaine Randrian, David Tougeron, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Communications Cellulaires et Différenciation (CCD), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Amiens-Picardie, AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Université Paris Cité (UPCité), Centre de Bioinformatique (CBIO), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris sciences et lettres (PSL), Hôpital Avicenne [AP-HP], Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Hôpital Cochin [AP-HP], CHU Limoges, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Université de Reims Champagne-Ardenne (URCA), Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Hepatology, [SDV]Life Sciences [q-bio], Gastroenterology, Humans, Microsatellite Instability, Middle Aged, Prognosis, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Mismatch Repair
Abstract: Data on outcomes of microsatellite instable and/or mismatch repair deficient (dMMR/MSI) digestive non-colorectal tumors are limited.To evaluate overall survival (OS) of patients with dMMR/MSI digestive non-colorectal tumor.All consecutive patients with a dMMR/MSI digestive non-colorectal tumor were included in this French retrospective multicenter study.One hundred and sixteen patients were included with a mean age of 63.6 years and 32.6% with a Lynch syndrome. Most tumors were oesophago-gastric (54.3%) or small bowel (32.8%) adenocarcinomas and at a localized stage at diagnosis (86.7%). In patients with localized tumors and R0 resection, median OS was 134.0 ± 64.2 months. Median disease-free survival (DFS) was 100.3 ± 65.7 months. Considering oesophago-gastric tumors, median DFS was improved when chemotherapy was added to surgery (not reached versus 22.8 ± 10.0 months, p = 0.03). In patients with advanced tumors treated by chemotherapy, median OS was 14.2 ± 1.9 months and median progression-free survival was 7.4 ± 1.6 months.dMMR/MSI digestive non-colorectal tumors are mostly diagnosed at a non-metastatic stage with a good prognosis. Advanced dMMR/MSI digestive non-colorectal tumors have a poor prognosis with standard chemotherapy.
Published: 2023

237. Analysis of passive cardiac constitutive laws for parameter estimation using 3D tagged MRI

Author: Reza Razavi, Liya Asner, Myrianthi Hadjicharalambous, Gerald Carr-White, Eva Sammut, Jack Lee, Nicolas P. Smith, David Nordsletten, Radomir Chabiniok, James Wong, Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Faculty of Engineering [Auckland], University of Auckland [Auckland], École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Adult, Male, Engineering, Relation (database), [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, media_common.quotation_subject, 0206 medical engineering, Constitutive equation, Fidelity, 02 engineering and technology, Parameter space, Displacement (vector), 3D tagged MRI, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Imaging, Three-Dimensional, 0302 clinical medicine, Diastole, Modelling and Simulation, Parameter estimation, Pressure, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Humans, Practical identifiability, media_common, Original Paper, Patient-specific modeling, Ground truth, business.industry, Estimation theory, Mechanical Engineering, Models, Cardiovascular, Heart, Magnetic Resonance Imaging, 020601 biomedical engineering, Cardiac mechanics, Modeling and Simulation, Law, Identifiability, Constitutive laws, business, Biotechnology
Abstract: International audience; An unresolved issue in patient-specific models of cardiac mechanics is the choice of an appropriate constitutive law, able to accurately capture the passive behavior of the myocardium, while still having uniquely identifiable parameters tunable from available clinical data. In this paper, we aim to facilitate this choice by examining the practical identifiability and model fidelity of constitutive laws often used in cardiac mechanics. Our analysis focuses on the use of novel 3D tagged MRI, providing detailed displacement information in three dimensions. The practical identifiability of each law is examined by generating synthetic 3D tags from in silico simulations, allowing mapping of the objective function landscape over parameter space and comparison of minimizing parameter values with original ground truth values. Model fidelity was tested by comparing these laws with the more complex transversely isotropic Guccione law, by characterizing their passive end-diastolic pressure–volume relation behavior, as well as by considering the in vivo case of a healthy volunteer. These results show that a reduced form of the Holzapfel–Ogden law provides the best balance between identifiability and model fidelity across the tests considered.
Published: 2014

238. Reactive transport models of the geochemical interactions at the iron/bentonite interface in laboratory corrosion tests

Author: Alba Mon, Javier Samper, Luis Montenegro, María Jesús Turrero, Elena Torres, Jaime Cuevas, Raúl Fernández, Laurent De Windt, Centro de Investigaciones Científicas Avanzadas (CICA), Facultade de Ciencias, Universidade da Coruña, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Universidad Autónoma de Madrid (UAM), Centre de Géosciences (GEOSCIENCES), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and European Project: 847593,EURAD(2019)
Subjects: Canister corrosion, THCM model, Geochemistry and Petrology, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Bentonite, Reactive transport, Geology, Corrosion products, Fe powder
Abstract: International audience; Carbon steel and compacted bentonite have been proposed as candidate materials for the overpack and buffer, respectively, of the multi-barrier system of a geological high-level radioactive waste repository. Carbon steel corrosion may impair bentonite properties. The interactions of corrosion products and bentonite are analyzed with laboratory corrosion tests. Here coupled thermo-hydro-chemical-mechanical (THCM) models of two types of heating and hydration tests performed on compacted bentonite in contact with Fe powder are presented to study the iron-bentonite interactions at representative repository conditions. Tests on small cells (SC) were performed under unsaturated non-isothermal conditions in 25 mm long columns containing 21 mm of bentonite and 4 mm of Fe powder. Tests on medium-size cells (FB) were performed under unsaturated non-isothermal conditions in 99.8 mm long columns containing 86.8 mm of bentonite and 13 mm of Fe powder. Model results for the SC tests showed that magnetite and Fe(OH) 2 (s) were the main corrosion products which compete for Fe 2+ precipitation. Computed corrosion products precipitate mainly in the Fe powder, penetrate a few mm into the bentonite and reproduce the measured iron weight data. Model results of the FB tests showed that magnetite precipitates throughout the Fe powder interface and reproduce the main trends of the corrosion products. Model results of these corrosion tests will be of great relevance for the performance assessment of engineered barriers of radioactive waste repositories.
Published: 2023

239. Integrating logistics operations for sustainable last-mile deliveries with a consolidation-based assignment heuristic

Author: Limbourg, Sabine, Achamrah, Fatima Ezzahra, Baiwir, Tanguy, Peters, Florian, HEC Liège, Centre de Gestion Scientifique i3 (CGS i3), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut interdisciplinaire de l’innovation (I3), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and European Project
Subjects: 3PL, Sustainable Transportation, [INFO]Computer Science [cs], Last-Mile Delivery
Abstract: International audience; The City Line project aims to promote collaboration between logistics operators and ensure low emissions for last-mile deliveries in cities. This collaboration involves sharing existing assets and capacities, logistics facilities, and services with competitors to save costs, improve global transport efficiency, and extend one's service zone. It is based on negotiating framework contracts with transport providers that occur before collaboration.An algorithm uses a depth-first search strategy for each commodity, starting from a set of services that can pick up the delivery request at its origin and within the pickup time window. The search continues by appending services that can drop off at the destination location within the drop-off time window. The search terminates when no more services are to be appended or when the maximum number of intermediate stops is reached. It results in a set of feasible paths, each of which is a sequence of services. Then, for each period within the rolling horizon, the algorithm selects the path with the minimum score depending on cost and environmental impacts, and assigns the delivery request to this path, updating the capacities of the services in the path accordingly. Delivery requests for subsequent periods within the rolling horizon are assigned to the used paths that can accommodate the new request with the least additional capacity requirement using the BestFit algorithm. The potential impacts of collaboration and low-emission zones are analyzed in Belgium through four scenarios. Six types of vehicles, each with its characteristics and emissions, are included, and costs are computed considering the weight and volume of parcels. The results show that increased collaboration among logistics service providers leads to higher loading rates, greater acceptance of delivery requests, and more diverse use of vehicles, significantly reducing CO2 and NOX emissions. These findings offer promising implications for adopting collaborative transport and sustainable logistics, contributing to developing the Physical Internet concept. The study's results could also provide valuable insights for policymakers in developing decision-support tools to promote sustainable logistics practices.The City Line project aims to promote collaboration between logistics operators and ensure low emissions for last-mile deliveries in cities. This collaboration involves sharing existing assets and capacities, logistics facilities, and services with competitors to save costs, improve global transport efficiency, and extend one's service zone. It is based on negotiating framework contracts with transport providers that occur before collaboration.An algorithm uses a depth-first search strategy for each commodity, starting from a set of services that can pick up the delivery request at its origin and within the pickup time window. The search continues by appending services that can drop off at the destination location within the drop-off time window. The search terminates when no more services are to be appended or when the maximum number of intermediate stops is reached. It results in a set of feasible paths, each of which is a sequence of services. Then, for each period within the rolling horizon, the algorithm selects the path with the minimum score depending on cost and environmental impacts, and assigns the delivery request to this path, updating the capacities of the services in the path accordingly. Delivery requests for subsequent periods within the rolling horizon are assigned to the used paths that can accommodate the new request with the least additional capacity requirement using the BestFit algorithm. The potential impacts of collaboration and low-emission zones are analyzed in Belgium through four scenarios. Six types of vehicles, each with its characteristics and emissions, are included, and costs are computed considering the weight and volume of parcels. The results show that increased collaboration among logistics service providers leads to higher loading rates, greater acceptance of delivery requests, and more diverse use of vehicles, significantly reducing CO2 and NOX emissions. These findings offer promising implications for adopting collaborative transport and sustainable logistics, contributing to developing the Physical Internet concept. The study's results could also provide valuable insights for policymakers in developing decision-support tools to promote sustainable logistics practices.
Published: 2023

240. Error analysis of the Hybrid Hyper-Reduction method for frictionless contact problems

Author: Le Berre, Simon, Ramière, Isabelle, Ryckelynck, David, Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL), Centre des Matériaux (CDM), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), CEA, DES, IRESNE, DEC, SESC Cadarache F-13108 Saint-Paul-Lez-Durance, France, and ECCOMAS (Thematic conference)
Subjects: [PHYS.MECA.SOLID]Physics [physics]/Mechanics [physics]/Solid mechanics [physics.class-ph], frictionless contact problems, Lagrange multipliers method, Error estimators, Hyper-Reduction, reduced order models, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: International audience
Published: 2023

241. Characterisation of 3D strain heterogeneity at the microstructure scale during Low Cycle Fatigue of an AlSi7Cu3Mg alloy at 250°C

Author: Nathalie Limodin, Nora Dahdah, Long Wang, Ahmed El Bartali, Jean-François Witz, Jean-Yves Buffiere, Eric Charkaluk, Laboratoire de Mécanique, Multiphysique, Multiéchelle - UMR 9013 (LaMcube), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and ANR-12-RMNP-0011,INDiANA,Influence des défauts de fonderie dans l'endommagement par fatigue thermomécanique oligocyclique des alliages d'aluminium obtenus par un procédé à modèle perdu(2012)
Subjects: Mechanics of Materials, Mechanical Engineering, Modeling and Simulation, Low cycle fatigue, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], High temperature fatigue, General Materials Science, Aluminium alloys, Digital volume correlation, Synchrotron radiation computed tomography, Industrial and Manufacturing Engineering
Abstract: International audience; 3D tomographic images of a cast AlSi7Cu3Mg alloy were obtained using synchrotron X-ray tomography during in-situ Low Cycle Fatigue tests at 250°C. While image analysis highlights the role of eutectic Si particles close to pores in damage mechanisms, high resolution digital volume correlation reveals the relationship between strain heterogeneity at the microstructural scale and hard particles failure or cracks. Monitoring strains evolution with cycles within hard particles, i.e. eutectic Si and Fe or Cu intermetallics, allows measuring their local failure strains and drawing a hierarchy of the deformation to failure. Then, a local Manson-Coffin curve per hard phase is proposed.
Published: 2023

242. Comparison of Systolic Period Duration Using Aortic Flow or Pressure Based Methods in Anesthetized Patients

Author: Denis Chemla, Arthur Le Gall, F. Vallée, Alexandre Laurin, Université Paris-Saclay, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière], Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Unité d'explorations fonctionnelles cardio-vasculaires [Hôpital Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, Le Gall, Arthur, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: medicine.medical_specialty, Materials science, Monitoring, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Afterload, 030202 anesthesiology, Internal medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Anesthesia, Pulse wave velocity, Systolic Period Duration, Pressure sensor, Arterial tree, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Pulse pressure, Blood pressure, Arterial Pressure Amplification, Flow velocity, Continuous noninvasive arterial pressure, Cardiology
Abstract: International audience; It has been shown that Systolic Period Duration (SPD) measured with trans-esophageal echocardiography (TEE) is significantly shorter compared to measurements made with radial arterial pressure waveform. This difference could be interpreted in terms of arterial pressure amplification , a mechanism by which arterial pressure waveform is transformed alongside the arterial tree. This amplification is closely related to cardiac afterload as it shares common determinants, like arterial stiffness, pulse wave velocity, or aortic reflection waves. In turn, afterload estimated partly using arterial pressure amplification is useful during general anesthesia (GA) to evaluate detrimental or beneficial effects of vasopressors given to combat hypotensions. Despite TEE measurements comport some impracticalities, trans-esophageal Doppler (TE Doppler) is routinely used for cardiac output monitoring. The goal of this paper was to compare SPD measured with TE Doppler and with arterial pressure at the same location. A secondary goal was to describe a novel dicrotic notch identification algorithm that uses the interspace between the pressure waveform and the straight line going from the systolic peak of one beat to the foot of the subsequent beat. Twenty three patients undergoing GA for neurointerventional procedures were included. Central pressure was obtained by fluid filled radiologic guidewire connected to a pressure transducer. Flow velocity waveform was obtained using TE Doppler probe inserted in the esophagus after induction of GA. Pressure and flow velocity measurements were recorded simultaneously when the tip of the pressure catheter was placed in front of the Doppler probe, in the descending Aorta. SPD measured from Flow velocity waveform was significantly shorter than from Pressure waveform (343 ± 46 ms vs 415 ± 54 ms; p < 0.001). Flow velocity and Pressure waveform methods are not interchangeable. To measure SPD consistently at different locations, a consistent algorithm should be used, such as automated identification of dicrotic notch.
Published: 2017

243. Improving the experimental protocol for a more accurate identification of a given mechanical behavior in a single assay: application to skin

Author: Affagard, Jean-Sébastien, Wijanto, Florent, Allain, Jean-Marc, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: anisotropy, biaxial traction, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], sensitivity, biomechanics, large strain
Abstract: International audience; Mechanical properties of the skin, the external organ of the human body, are important for many applications such as surgery or cosmetics. Due to the highly hierarchical structure of the tissue, it is interesting to develop microstructural models which have a better predictability and should reduce the consequences of the sample variability. However, these models generally include a quite large number of mechanical parameters. Therefore, complex assays are required to achieve a proper identification of the microstructural models. We investigated here the best experimental protocol to identify a non-linear, anisotropic, model of skin behavior, namely the Holzapfel's law, using displacement field and force measurements. This was done through a sensitivity analysis of the different parameters. We determined first the 1 optimal assay, which appears to be a biaxial test with an alternated loading: first a stretch in one direction, then in the perpendicular one, and so on. To further improve the quality of the assay, we also determined the optimal geometry. Interestingly, slightly asymmetric geometries are more adequate than symmetric ones, while being easier to realize.
Published: 2017

244. Stress corrosion cracking initiation of alloy 82 in hydrogenated steam

Author: Chaumun, Elizabeth, Crépin, Jérôme, Duhamel, Cecilie, Guerre, Catherine, Héripré, Eva, Sennour, Mohamed, Curières, Ian De, Centre des Matériaux (MAT), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Service de la Corrosion et du Comportement des Matériaux dans leur Environnement (SCCME), Département de Physico-Chimie (DPC), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), J.H Jackson, D. Paraventi, M. Wright, Centre des Matériaux (CDM), Mines Paris - PSL (École nationale supérieure des mines de Paris), and École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Hydrogenated steam, 020209 energy, Alloy 82, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, technology, industry, and agriculture, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 02 engineering and technology, Stress corrosion cracking, respiratory system, 01 natural sciences, 010305 fluids & plasmas
Abstract: International audience; Experiments in hydrogenated steam were performed on several U-bend specimens extracted from two Alloy 82 welds. Results demonstrated that Alloy 82 is susceptible to SCC in hydrogenated steam at 400 °C and its susceptibility depends on its chemical composition, welding process and thermal treatment. The microstructure was characterized in the apex of the U-bend specimens. Chemical analysis were performed by electron probe microanalyser (EPMA) and secondary ion mass spectrometry (SIMS) on several areas in the weld in order to correlate crack initiation with chemical heterogeneities. It was concluded that there are more cracks in the roots of the weld passes where the impurity content (sulfur, titanium and aluminum) is higher.
Published: 2017

245. Structure-preserving adiabatic elimination for open bipartite quantum systems

Author: Azouit, Rémi, Chittaro, Francesca, Sarlette, Alain, Rouchon, Pierre, QUANTum Information Circuits (QUANTIC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre Automatique et Systèmes (CAS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-MINES ParisTech - École nationale supérieure des mines de Paris, MINES ParisTech - École nationale supérieure des mines de Paris, Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract: International audience; We consider a quantum system composed of a fast quantum subsystem coupled to a slow one. We provide expressions of the approximate reduced model describing the slow subsystem perturbed by the fast one (adiabatic elimination), based on an asymptotic expansion that we solve up to second order. The specificity of our expressions is to preserve the quantum structure in the reduced model: we provide the reduced dynamics in Lindblad form, and the mapping defining the slow manifold as a completely positive map in Kraus form.
Published: 2017

246. Norepinephrine reduces arterial compliance less than phenylephrine when treating general anesthesia-induced arterial hypotension

Author: O. Passouant, Alexandre Mebazaa, J. Mateo, Jona Joachim, Etienne Gayat, A. Le Gall, F. Vallée, Université Paris-Saclay, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Département d'Anesthésie Réanimation SMUR [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Le Gall, Arthur, Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France
Subjects: Adult, Male, Cardiac output, hypotension, 030204 cardiovascular system & hematology, Anesthesia, General, 03 medical and health sciences, Norepinephrine, Phenylephrine, 0302 clinical medicine, Bolus (medicine), Vascular Stiffness, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 030202 anesthesiology, Monitoring, Intraoperative, Medicine, Humans, Vasoconstrictor Agents, Arterial Pressure, Prospective Studies, Cardiac Output, Aged, tonometry, business.industry, Doppler, Stroke Volume, vasopressors, General Medicine, Stroke volume, Arteries, Middle Aged, medicine.disease, general anesthesia, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Pulse pressure, Anesthesiology and Pain Medicine, Blood pressure, Anesthesia, Aortic pressure, Arterial stiffness, ventricular arterial coupling, Female, business, medicine.drug, Compliance
Abstract: International audience; Introduction: During general anesthesia, arterial hypotension is frequent and may be an important contributor to peri-operative morbidity. We assessed the effect of a 5µg bolus of Norepinephrine (NA) when compared with 50 µg bolus of Phenylephrine (PE) administered to treat hypotension during maintenance anesthesia, on MAP, derived cardiac output and arterial stiffness parameters. Methods: Patients scheduled for a neurosurgical procedure under general anesthesia were prospectively included. Monitoring included invasive blood pressure, esophageal Doppler and arterial tonometer used to estimate central aortic pressure with arterial stiffness parameters, such as augmentation index (Aix). After initial resuscitation, hypotensive episodes were corrected by a bolus administration of NA or PE in a peripheral venous line. Results: There were 269 bolus administrations of vasopressors (149 NA, 120 PE) in 47 patients with no adverse effects detected. A decrease in stroke volume (SV) was observed with PE compared with NA (-18±9% vs -14±7%, p
Published: 2017

247. New indices from microneurography to investigate the arterial baroreflex

Author: Laurin, Alexandre, Lloyd, Matthew G., Hachiya, Tesshin, Saito, Mitsuru, Claydon, Victoria E., Blaber, Andrew, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Simon Fraser University (SFU.ca), Department of Biomedical Physiology and Kinesiology (BPK), Nagoya University, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris
Subjects: microneurography, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Baroreflex, signal analysis, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Baroreflex‐mediated changes in heart rate and vascular resistance in response to variations in blood pressure are critical to maintain homeostasis. We aimed to develop time domain analysis methods to complement existing cross‐spectral techniques in the investigation of the vascular resistance baroreflex response to orthostatic stress. A secondary goal was to apply these methods to distinguish between levels of orthostatic tolerance using baseline data. Eleven healthy, normotensive males participated in a graded lower body negative pressure protocol. Within individual neurogenic baroreflex cycles, the amount of muscle sympathetic nerve activity (MSNA), the diastolic pressure stimulus and response amplitudes, diastolic pressure to MSNA burst stimulus and response times, as well as the stimulus and response slopes between diastolic pressure and MSNA were computed. Coherence, gain, and frequency of highest coherence between systolic/diastolic arterial pressure (SAP/DAP) and RR‐interval time series were also computed. The number of MSNA bursts per low‐frequency cycle increased from 2.55 ± 0.68 at baseline to 5.44 ± 1.56 at −40 mmHg of LBNP. Stimulus time decreased (3.21 ± 1.48–1.46 ± 0.43 sec), as did response time (3.47 ± 0.86–2.37 ± 0.27 sec). At baseline, DAP‐RR coherence, DAP‐RR gain, and the time delay between decreases in DAP and MSNA bursts were higher in participants who experienced symptoms of presyncope. Results clarified the role of different branches of the baroreflex loop, and suggested functional adaptation of neuronal pathways to orthostatic stress.
Published: 2017

248. Equilibrated Warping: Finite Element Image Correlation with Mechanical Regularization

Author: Genet, Martin, Lee, Lik Chuan, Kozerke, Sebastian, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Michigan State University [East Lansing], Michigan State University System, Institute for Biomedical Engineering [ETH Zürich] (IBT), Universität Zürich [Zürich] = University of Zurich (UZH)-Department of Information Technology and Electrical Engineering [Zürich] (D-ITET), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: Image Correlation, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Finite elements, Hyperelasticity, [SPI.MECA.SOLID]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Solid mechanics [physics.class-ph], Mechanical Regularization
Abstract: International audience; Image correlation/registration is playing an increasing role in many domains such as biomedical engineering. Despite significant progress in the past decades, robustness, efficiency and precision of existing methods and tools must still be improved to translate them into medical and engineering applications. This abstract describes a finite element-based image correlation method with, as regularization, a novel continuum large deformation formulation of the equilibrium gap principle (introduced in [Claire et al., 2004] at the discrete level for linearized elasticity).
Published: 2017

249. Assessment of atrioventricular valve regurgitation using biomechanical cardiac modeling

Author: Chabiniok, Radomir, Moireau, Philippe, Kiesewetter, Christoph, Hussain, Tarique, Razavi, Reza, Chapelle, Dominique, Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, University of Texas Southwestern Medical Center [Dallas], Pop M and Wright G, Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Inria Saclay - Ile de France, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)
Subjects: therapy planning, reduced-order model, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB]Life Sciences [q-bio]/Bioengineering, atrioventricular regurgitation, model-based diagnosis assistance, cardiac modeling
Abstract: International audience; In this work we introduce the modeling of atrioventricular valve regurgitation in a spatially reduced order biomechanical heart model. The model can be fast calibrated using non-invasive data of cardiac magnetic resonance imaging and provides an objective measure of contractile properties of the myocardium in the volume overloaded ven-tricle, for which the real systolic function may be masked by the significant level of the atrioventricular valve regurgitation. After demonstrating such diagnostic capabilities, we show the potential of modeling to address some clinical questions concerning possible therapeutic interventions for specific patients. The fast running of the model allows targeting specific questions of referring clinicians in a clinically acceptable time.
Published: 2017

250. Joint-state and parameters estimation using nudging and SEIK filters for HIV mechanistic models

Author: PRAGUE, Mélanie, THIÉBAUT, Rodolphe, MOIREAU, Philippe, COLLIN, Annabelle, Statistics In System biology and Translational Medicine (SISTM), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, Institut Polytechnique de Bordeaux (Bordeaux INP), Modélisation Mathématique pour l'Oncologie (MONC), Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER-Inria Bordeaux - Sud-Ouest, Prague, Mélanie, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Institut Bergonié [Bordeaux]
Subjects: [SDV.IMM.VAC] Life Sciences [q-bio]/Immunology/Vaccinology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST]
Abstract: National audience; Différentes méthodes ontétéontété utilisées dans le domaine de la statistique pour estimer les paramètres dans les modèles mécanistes. En particulier, l'approche basée sur la vraissemblance pénalisée pour l'estimation des paramètres dans leséquationsleséquations différentielles ordinaires avec des modèles non linéaireslinéairesà effets mixtes sur les paramètres (ODE-NLME) est souvent employée. Nous utilisons ici le programme NIMROD [Prague2013] comme référence pour l'estimation dans ces modèles. Cependant, une telle approche prend beaucoup de temps de calcul. Nous proposons d 'envisager l'assimilation de données, historiquement utilisée dans le contexte de la géophysique. Nous proposons un observateur d'´ etat de Luenberger couplé couplé`coupléà un observateur de Kalman (filtre RoUKF, ´ egalement appelé filtre SEIK) pour effectuer une estimation conjointe desétatsdesétats et des paramètres sur un ensemble de données composé d'observations longitudinales de biomarqueurs pour de multiples patients. Nous comparons ces méthodes en termes de performances et de temps de calcul. Nous discutons comment le concept d'effets aléatoires peutêtrepeutêtre modélisé en utilisant les filtres de Kalman et ses limites. Nous illustrons les deux méthodes en simulation et sur deux ensembles de données (l'essai clinique randomisé ALBI ANRS 070 et les données d'observation de la cohorte d'Aquitaine ANRS CO3) en utilisant un modèle mécaniste du VIH. Mots-clés. Bayésien; Equation Différentielle ordinaire; Kalman and Luenberger filters; Modèles m/'ecanistes; Modèles non linéairè a effets mixtes; VIH; Vraissemblance pénalisée. Abstract. Various methods have been used in the statistical field to estimate parameters in mechanistic models. In particular, approach based on penalised likelihood for estimation of parameters in ordinary differential equations with non linear models on parameters (ODE-NLME) has proven successful. We will consider the NIMROD program [Prague2013] as a benchmark for estimation in these models. However, such approach is time consuming. We propose to consider data assimilation which historically arose in the context of geophysics. We propose a Luenberger (also called nudging) state observer coupled with a parameter Kalman-based observer (RoUKF filter, also called SEIK filter) to perform a joint state and parameter estimation on a dataset composed of longitudinal observations of biomarkers for multiples patients. We compare these methods in term of performances and computation time. We discuss how the concept of random effect can be modelled using Kalman-based filter and its limitations. We illustrate both methods in simulation and on two datasets 1
Published: 2017

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