201. Uncommon chlorinated xanthone and other antibacterial compounds from the lichen Cladonia incrassata.
- Author
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Dieu A, Millot M, Champavier Y, Mambu L, Chaleix V, Sol V, and Gloaguen V
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Aspergillus drug effects, Benzofurans chemistry, Benzofurans isolation & purification, Candida albicans drug effects, Halogenation, Microbial Sensitivity Tests, Molecular Structure, Staphylococcus aureus drug effects, Xanthenes chemistry, Xanthenes isolation & purification, Xanthones chemistry, Xanthones isolation & purification, Anti-Bacterial Agents pharmacology, Benzofurans pharmacology, Lichens chemistry, Xanthenes pharmacology, Xanthones pharmacology
- Abstract
Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (-)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (-)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL)., (Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2014
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