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209. The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study.

Author

Fiona Matthews, Carol Brayne, and Medical Research Council Cognitive Function and Ageing Study Investigators

Subjects
Medicine
Abstract

BackgroundAlthough incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted multisite incidence studies in order to facilitate national comparisons. This study aims to provide robust measures of the variation of the incidence of dementia across sites within England and Wales and produce overall estimates by age and sex.Methods and findingsThe Medical Research Council Cognitive Function and Ageing Study used identical methodology in five diverse sites across the United Kingdom, each with different risk patterns and mortality rates. Incidence has been estimated using likelihood-based methods between the first two waves of interviews. Incidence rates rise with age, particularly above the age of 75 y, from 6.7 [corrected] (95% confidence interval, 3.8 [corrected]-12.4 [corrected]) per 1,000 person years at age 65-69 y to 68.5 [corrected] (95% confidence interval, 52.5 [corrected]-88.1 [corrected]) per 1,000 person years at age 85 y and above. The rate of increase for both sexes is marked, and continues into the oldest age groups. Hence, it is estimated that approximately 163,000 [corrected] new cases of dementia occur in England and Wales each year. There is no convincing evidence of variation across sites, and incidence rates do not reflect the variations in the prevalence of possible risk factors in these sites.ConclusionThere is no evidence, within England and Wales, of variation in dementia incidence across sites. Dementia incidence rates do not tail off at the oldest ages.

Published
2005
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214. Catalysing the Containment of COVID-19 (C3-RCT)

Author

Medical Research Council, South Africa, Aurum Institute, National Institutes of Health (NIH), Texas Tech University Health Sciences Center, University of KwaZulu, Perinatal HIV Research Unit of the University of the Witswatersrand, and Keertan Dheda, Professor

Published
2022

226. Praziquantel in Children Under Age 4 (PIPS)

Author

London School of Hygiene and Tropical Medicine, University of Liverpool, Research Institute for Tropical Medicine, Philippines, Medical Research Council, and Jennifer Friedman, MD, PhD, Director, Center for International Health Research

Published
2022

243. Point-of-care Triage Test for Active Tuberculosis (TriageTB)

Author

London School of Hygiene and Tropical Medicine, Makerere University, Find, Leiden University Medical Center, Medical Research Council Unit, The Gambia, LINQ Management GMBH, and Prof Gerhard Walzl, Executive Head of Department of Biomedical Sciences

Published
2022

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