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400 results on '"McCULLOUGH, J P"'

201. Photo-addition of indene and acrylonitrile: orientation and stereochemistry of the cycloadducts

Author

Bowman, R. M., McCullough, J. J., and Swenton, J. S.

Abstract

The cyclobutanes obtained on photosensitized cyclo-addition of indene and acrylonitrile have been reinvestigated and the structures formerly assigned (1) have been unambiguously confirmed. The photo-addition of indene and cyanoacetylene has been shown to smoothly afford a single adduct, 7-cyano-2,3-benzobicyclo[3.2.0]hepta-2,6-diene.

Published
1969
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205. Towards blood flow in the virtual human: efficient self-coupling of HemeLB

Author

McCullough, J. W. S., Richardson, R. A., Patronis, A., Halver, R., Marshall, R., Ruefenacht, M., Wylie, B. J. N., Odaker, T., Wiedemann, M., Lloyd, B., Neufeld, E., Sutmann, G., Skjellum, A., Kranzlmüller, D., and Coveney, P. V.

Abstract

Many scientific and medical researchers are working towards the creation of a virtual human—a personalized digital copy of an individual—that will assist in a patient’s diagnosis, treatment and recovery. The complex nature of living systems means that the development of this remains a major challenge. We describe progress in enabling the HemeLB lattice Boltzmann code to simulate 3D macroscopic blood flow on a full human scale. Significant developments in memory management and load balancing allow near linear scaling performance of the code on hundreds of thousands of computer cores. Integral to the construction of a virtual human, we also outline the implementation of a self-coupling strategy for HemeLB. This allows simultaneous simulation of arterial and venous vascular trees based on human-specific geometries.

Published
2021
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206. Control of growth factor receptor dynamics by reversible ubiquitination

Author

Urbé, S., McCullough, J., Row, P., Prior, I.A., Welchman, R., and Clague, M.J.

Abstract

Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the lysosome. We have characterized two de-ubiquitinating enzymes that interact with components of this machinery. AMSH [associated molecule with the SH3 domain (Src homology 3 domain) of STAM (signal transducing adapter molecule)] shows specificity for Lys63- over Lys48-linked ubiquitin and may act to rescue receptors from taking the lysosomal pathway. In contrast, UBPY (ubiquitin-specific processing protease Y) does not discriminate between Lys48 and Lys63-linked chains and is required for lysosomal sorting.

Published
2006
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207. 1,2-DIFLUOROBENZENE: CHEMICAL THERMODYNAMIC PROPERTIES AND VIBRATIONAL ASSIGNMENT

Author

BUREAU OF MINES BARTLESVILLE OK THERMODYNAMICS LAB, Scott, D. W., Messerly, J. F., Todd, S. S., Hossenlopp, I. A., Osborn, Ann, McCullough, J. P., BUREAU OF MINES BARTLESVILLE OK THERMODYNAMICS LAB, Scott, D. W., Messerly, J. F., Todd, S. S., Hossenlopp, I. A., Osborn, Ann, and McCullough, J. P.

Abstract

Pub. in the Journal of Chemical Physics, v38 n2, p532-539, 15 Jan 1963. Sponsored in part by DARPA.

Published
1962

216. Thermodynamic Properties of Furan

Author

Guthrie, G. B., primary, Scott, D. W., additional, Hubbard, W. N., additional, Katz, C., additional, McCullough, J. P., additional, Gross, M. E., additional, Williamson, K. D., additional, and Waddington, Guy, additional

Published
1952
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