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203. Tumor Imaging

Author

Mayr, Nina A., primary, Lo, Simon S., additional, Grecula, John, additional, Wang, Jian, additional, Zhang, Hualin, additional, Montebello, Joseph, additional, Martin, Douglas, additional, and Yuh, William T., additional

Published
2006
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214. Normal Tissue Constraints.

Author

Lo, Simon S., Sahgal, Arjun, Ma, Lijun, Slotman, Ben J., Huang, Zhibin, Mayr, Nina A., Kunos, Charles A., Teh, Bin S., Machtay, Mitchell, and Chang, Eric L.

Published
2012
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221. Fractionated Grid Therapy in Treating Cervical Cancer.

Author

Kim, Sun I., Suh, Tae Suk, Magjarevic, R., Nagel, J. H., Zhang, Hualin, Wang, Jian Z., Mayr, Nina, Yuh, William, Grecula, John, and Montebello, Joseph

Abstract

Purpose: To evaluate the potential therapeutic advantage of external beam grid therapy in treating cervical cancers in comparison of conventional open field radiotherapy. Method and Materials: A Monte Carlo technique is employed to calculate 2-dimensinal dose distribution of a commercially available grid, and the linear-quadratic (LQ) model was applied to study the therapeutic advantage of using grid therapy for treating cervical cancers. A list of cervical cancer cell lines with known LQ parameters were employed to calculate the radiotherapy response. Acutely responding Normal muscle with α/β value of 3.1 Gy was used to evaluate the outcome between the open and grid field irradiations. The normal muscle tissue was further classified as three types of cells according to their response to a 2Gy open field. The therapeutic ratio based on normal cell survival has been defined and calculated for treating both the acute and late responding cervical cancer. 2Gy per fraction and 5 to 20 fractions were used in the calculations. Results: The normal tissue as well as tumor cell survival fractions and therapeutic ratios for the open and grid field are calculated. An appreciable therapeutic advantage has been demonstrated. Therapeutic ratio up to 9.5 for radio-sensitive normal muscles was found. However, the radio-resistant muscle does not show apparent advantage benefiting from the grid therapy. The results of data analysis showed that the therapeutic outcome is dependent not only on the single value α/β, but also on the individual α and β values from both the tumor and normal tissue cells. Conclusion: Monte Carlo technique was proven to be able to provide the dosimetric characteristics for grid therapy. The grid therapy in this study was found to be advantageous for treating the acutely responding cervical tumors (α/β>6), but not for late responding ones (α/β≤6). The acutely responding tumors and radio-sensitive normal tissues are more suitable for using the grid therapy. [ABSTRACT FROM AUTHOR]

Published
2007
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223. Intracranial Ependymomas

Author

Paulino, Arnold C., primary, Wen, B.-Chen, additional, Buatti, John M., additional, Hussey, David H., additional, Zhen, Weining K., additional, Mayr, Nina A., additional, and Menezes, Arnold H., additional

Published
2002
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228. Letters to the editor

Author

Mayr, Nina A, primary, Taoka, Toshiaki, additional, Yuh, William T.C, additional, Zhen, Weining K, additional, Paulino, Arnold C, additional, Sorosky, Joel I, additional, and Buatti, John M, additional

Published
2000
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229. Pixel analysis of MR perfusion imaging in predicting radiation therapy outcome in cervical cancer

Author

Mayr, Nina A., primary, Yuh, William T.C., additional, Arnholt, Jeffrey C., additional, Ehrhardt, James C., additional, Sorosky, Joel I., additional, Magnotta, Vincent A., additional, Berbaum, Kevin S., additional, Zhen, Weining, additional, Paulino, Arnold C., additional, Oberley, Larry W., additional, Sood, Anil K., additional, and Buatti, John M., additional

Published
2000
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230. International Outreach: What Is the Responsibility of ASTRO and the Major International Radiation Oncology Societies?

Author

Mayr, Nina A., Hu, Kenneth S., Liao, Zhongxing, Viswanathan, Akila N., Wall, Terry J., Amendola, Beatriz E., Calaguas, Miriam J., Palta, Jatinder R., Yue, Ning J., Rengan, Ramesh, and Williams, Timothy R.

Subjects
*CANCER patient care, *ONCOLOGY, *GLOBALIZATION, *OUTREACH programs, *EDUCATIONAL programs, *REGIONAL disparities
Abstract

In this era of globalization and rapid advances in radiation oncology worldwide, the American Society for Radiation Oncology (ASTRO) is committed to help decrease profound regional disparities through the work of the International Education Subcommittee (IES). The IES has expanded its base, reach, and activities to foster educational advances through a variety of educational methods with broad scope, in addition to committing to the advancement of radiation oncology care for cancer patients around the world, through close collaboration with our sister radiation oncology societies and other educational, governmental, and organizational groups. [Copyright &y& Elsevier]

Published
2014
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233. Estimating kinetic parameters from dynamic contrast-enhanced t1-weighted MRI of a diffusable tracer: Standardized quantities and symbols

Author

Tofts, Paul S., primary, Brix, Gunnar, additional, Buckley, David L., additional, Evelhoch, Jeffrey L., additional, Henderson, Elizabeth, additional, Knopp, Michael V., additional, Larsson, Henrik B.W., additional, Lee, Ting-Yim, additional, Mayr, Nina A., additional, Parker, Geoffrey J.M., additional, Port, Ruediger E., additional, Taylor, June, additional, and Weisskoff, Robert M., additional

Published
1999
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241. Tumor perfusion studies using fast magnetic resonance imaging technique in advanced cervical cancer: A new noninvasive predictive assay

Author

Mayr, Nina A., primary, Yuh, William T.C., additional, Magnotta, Vincent A., additional, Ehrhardt, James C., additional, Wheeler, James A., additional, Sorosky, Joel I., additional, Davis, Charles S., additional, Wen, B.-Chen, additional, Martin, Douglas D., additional, Pelsang, Retta E., additional, Buller, Richard E., additional, Oberley, Larry W., additional, Mellenberg, David E., additional, and Hussey, David H., additional

Published
1996
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243. Usefulness of tumor volumetry by magnetic resonance imaging in assessing response to radiation therapy in carcinoma of the uterine cervix

Author

Mayr, Nina A., primary, Magnotta, Vincent A., additional, Ehrhardt, James C., additional, Wheeler, James A., additional, Sorosky, Joel I., additional, Wen, B.-Chen, additional, Davis, Charles S., additional, Pelsang, Retta E., additional, Anderson, Barrie, additional, Doornbos, J.Fred, additional, Hussey, David H., additional, and Yuh, William T.C., additional

Published
1996
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248. The α/βratio dose-range independent: application of the generalized linear-quadratic (gLQ) model

Author

Zhang, Cancan, Mayr, Nina, Lo, Simon, Lu, Lanchun, Li, Kaile, Zheng, Yi, Yuh, William, and Huang, Zhibin

Abstract

The dose-range dependence of α/βratio of the linear-quadratic (LQ) model for ≥10 Gy single doses has recently been reported. We previously proposed a generalized LQ (gLQ) model to address the LQ model limitations in large-dose regions. Here, we apply the gLQ model to large-dose-range in vitro irradiation data to investigate the dose-range dependence of the α/βratio. In vitro datasets of Chinese hamster cells in a large-dose range (0∼11.5 Gy), human lung carcinoma cells SW-1573 (0–10 Gy), and three cell lines (U373MG, CP3, and DU145) were studied. The cell lines had been irradiated up to 14 Gy in steps of 0.5 Gy. Both LQ and gLQ models were used to fit the datasets. Goodness of fit was determined by the least χ2(χ2min) method and model parameters errors by propagating χ2min. The α/βratios from both models were investigated across dose ranges from 0 Gy to the varying final doses. The α/βratio derived from the LQ model was dose-range dependent. For doses from 5 to 14 Gy, α/βratio increased from 2.8 to 9.3 Gy, 0.67 to 3.3 Gy, and 3.8 to 19.6 Gy for U373MG, CP3, and DU145, respectively. However, α/βratios from the gLQ model remained almost constant across the same dose range: 1.0 Gy, 0.027 Gy, and 1.8 Gy, respectively. The gLQ model provided improved fit over the LQ model across the entire dose range, showing reduced χ2minof 1.5, 1.5, and 4.4 vs. 3.2, 2.7, and 7.2 for U373MG, CP3, and DU145, respectively. Standard error α/βratios were much smaller and decreased more rapidly with increasing final dose using gLQ fitting compared to LQ fitting. The gLQ model provides dose-rate independent α/βratio, suggesting greater stability of model parameters and more consistent interpretation of cell irradiation data.

Published
2015
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249. 68 Usefulness of tumor volumetry by magnetic resonance (MR) imaging in assessing response to radiation therapy in carcinoma of the uterine cervix

Author

Hussey, David H., primary, Mayr, Nina A., additional, Magnotta, Vincent A., additional, Wheeler, James A., additional, Sorosky, Joel I., additional, Squatrito, Robert C., additional, Davis, Charles S., additional, Doombos, J. Fred, additional, Anderson, Barrie, additional, and Wen, B-Chen, additional

Published
1995
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