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3,070 results on '"Maruyama, H."'

219. Concomitant enhancement of the response to Mls-1a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice

Author

Murakami, K., Hosono, M., Maruyama, H., Mori, Y., Nishio, A., Fukumoto, M., Watanabe, Y., Inaba, M., Kuribayashi, K., Sakai, M., and Masuda, T.

Subjects
Male, Mice, Inbred BALB C, Mice, Inbred C3H, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, Immunoglobulins, Other Animal Models, Thymus Gland, Flow Cytometry, Autoimmune Diseases, Minor Lymphocyte Stimulatory Antigens, Mice, Parietal Cells, Gastric, Mice, Inbred DBA, Gastritis, Prevalence, Animals, Female, Autoantibodies
Abstract

We examined the role of Mls antigens in the induction of autoimmune gastritis (AIG) in BALB/c and DBA/2 mice subjected to thymectomy. The prevalence of AIG in Mls-1b mice which underwent thymectomy on day 3 after birth (3d-Tx) was 78% (mean), while in Mls-1a DBA/2 mice it was6%. Whereas AIG-negative 3d-Tx DBA/2 mice produced 2-mercaptoethanol (2-ME)-sensitive antiparietal cell autoantibody, AIG-positive BALB/c mice made 2-ME-resistant anti-parietal cell autoantibody. In addition, the prevalence of AIG in 3d-Tx BALB/c mice which were rendered tolerant to MIs-1a antigens by injection of bone marrow cells from (BALB/c x DBA/2)F1 mice within 24 h after birth was decreased compared with the non-tolerant control mice; the prevalence being 80% in the controls and 30% in the tolerant animals. Thus, the activation of helper T cells, including T cells responding to Mls-1a antigens and including immunoglobulin class switch, appeared to be closely associated with the induction of AIG. Flowcytometric analysis confirmed that CD4- V beta 6 T cells had increased in the regional lymph nodes of the stomach in AIG mice. However, an increase in the number of V beta 11 T cells, which are known to increase in 3d-Tx mice, occurred in the CD8, but not in the CD4 T cell population. Injection of MoAb to L3T4, but not Lyt2, V beta 6- or V beta 8-TCR, into 3d-Tx BALB/c and syngeneic nude mice which had received spleen cells of 3d-Tx BALB/c mice bearing AIG completely abrogated the development of AIG, despite there being remarkable decreases in T cells expressing relevant markers to the injected antibodies in all the mice. These findings suggest that the increase of V beta 6+ L3T4+ T cells in AIG mice was concomitant with the activation of AIG-inducing V beta 6- L3T4+ T cells.

Published
1993

220. A 1.13um2 Memory Cell Technology for Reliable 3.3V 64M NAND EEPROMs

Author

K. Hatakeyama, T. Maruyama H. Watanabe, T. Yamaguchi, S. Aritome, Koji Sakui, Tetsuo Endoh, Susumu Shuto, Gertjan Hemink, H. Iizuka, Toshihiro Tanaka, Riichiro Shirota, and Masaki C O Patent Div Momodomi

Subjects
Materials science, Memory cell, business.industry, Embedded system, NAND gate, business
Published
1993

233. An ultrahigh-speed color video camera operating at 1,000,000 fps with 288 frame memories

Author

Kitamura, K., primary, Arai, T., additional, Yonai, J., additional, Hayashida, T., additional, Kurita, T., additional, Maruyama, H., additional, Namiki, J., additional, Yanagi, T., additional, Yoshida, T., additional, van Kuijk, H., additional, Bosiers, Jan T., additional, Saita, A., additional, Kanayama, S., additional, Hatade, K., additional, Kitagawa, S., additional, and Etoh, T. Goji, additional

Published
2008
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241. An Ultrahigh-Speed, High-Sensitivity, Portable CCD Color Camera

Author

Kitamura, K., primary, Arai, T., additional, Yonai, J., additional, Hayashida, T., additional, Kurita, T., additional, Tanioka, K., additional, Maruyama, H., additional, Mita, Y., additional, Namiki, J., additional, Yanagi, T., additional, Yoshida, T., additional, van Kuijk, H., additional, Bosiers, Jan T., additional, and Etoh, T. Goji, additional

Published
2008
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