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This article was presented at the ICACER 2022 conference. The energetic performance of a building insulation coating is assessed by means of simulations of a dynamic RC model and by carrying out a parametric analysis based on Design of Experiment techniques. The external insulation coating is characterized by three parameters: the thermal conductive resistance, the shortwave solar absorptivity, and the longwave emissivity. The façade of the building is modelled with two lumped thermal capacitances on the internal and the external surfaces, and two thermal resistances representing the conduction through the wall and the internal convective and radiative phenomena. The external insulation is modelled by two more thermal resistances, which simulate the external convective exchanges and the conduction through the insulation, and one thermal capacitance in the insulation external surface. The inputs to the model are the external ambient temperature, the internal temperature, and the weather conditions (the wind convective heat transfer coefficient and the incident shortwave and the longwave radiative heat fluxes). The analyzed output parameter of the model is the internal surface heat flux, which has a direct impact on the heating and cooling loads. The Box-Behnken Design has been used to select the optimal values of the parameters of the insulation coating that result in a maximized internal heat flux during winter months and a minimized flux during summer months. The use of the Box-Behnken Design permits to assess the combined effect of the input parameters on the output parameter and the formulation of a simplified compact model to predict the latter as a function of the formers. The outcomes of the models suggest that surface emissivity is a key factor in summer periods while winter periods are mostly dominated by the thermal resistance in the wall.

Introduction Morgellons disease (MD) is a contested dermopathy that is associated with Borrelia spirochetal infection. A simple classification system was previously established to help validate the disease based on clinical features (classes I-IV). Methods Drawing on historical and pathological parallels with syphilis, we formulated a more detailed staging system based on clinical features as well as severity of skin lesions and corresponding histopathological infection patterns, as determined by anti-Borrelia immunohistochemical staining. Results Clinical classes I-IV of MD are further categorized as mild, moderate and severe, or stages A, B and C, respectively, based on histopathological findings. Stage A lesions demonstrated little or no immune infiltrates and little or no disorganization of cells; macrophages were not present, and hemorrhage was negligible. Extracellular isolated spirochetes and intracellular staining of keratinocytes in the lower epidermis was occasionally seen. Stage C lesions demonstrated positive staining of keratinocytes in the stratum basale and stratum spinosum and positive intracellular staining of macrophages for Borrelia. Aggregate Borrelia colonies were frequently encountered, hemorrhage was frequent, and intracellularly stained fibroblasts were occasionally seen. Stage B lesions demonstrated a pattern intermediate between Stages A and C. Conclusion The enhanced staging system provides objective criteria to assess the severity of dermopathy in MD. Further studies are needed to determine the optimal treatment for MD based on this staging system related to Borrelia infection., Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/0r3tVATtJxA

Understanding and monitoring coastal currents and sea-level variability play a key role in the management of coastal areas and activities of high socio-economic and environmental impact developed in the coastal fringe, all of them affected by the current climate change scenario. In this context, one of the main challenges of coastal altimetry is to achieve observations of the sea surface close to land. In coastal zones, altimetry signals are affected by the presence of land within the footprint of the instrument. Besides, derived oceanographic parameters, such as surface current velocities, are partially controlled by local agents, as small-scale wind variability and abrupt bathymetry. The former issue is partially solved by advances in new retracking processing, which allow obtaining accurate measurements up to 3 km from land. The second point must be addressed by the development of local corrections. In this work, surface geostrophic current velocities derived from CryoSat-2 and Sentinel-3A/B altimetry data have been successfully corrected with a wind correction derived from a high-resolution wind speed data from the Weather Research and Forecasting model (WRF). The total surface currents have been used to study the coastal circulation of the Gulf of Cádiz (southwestern Iberian Peninsula), from January to December, 2020. Total surface velocities were previously validated with high-frequency (HF) radar in the study area, obtaining solid statistical scores (correlations up to 0.95 and root mean square errors lower than 10 cm/s), up to 3 km from the coastline. The results and methodology presented state the need of understanding local agents for exploiting altimetric data for coastal oceanographic purposes. Besides, it shows the possibilities of using altimetric data in any coastal location where no other observing systems are available.

This book reviews the history and evolution of district heating networks, with a focus on current and future issues of the district heating sector. Novel developments in the field of low temperature district heating are studied, limitations for safe operation and avoidance of bacteria are considered, and the associated improved performance of the system with fewer network losses is presented. This book showcases how the evolution of district heating networks is linked to the increased use of renewables and de-carbonized heat sources with specific focus to waste heat streams and solar energy systems. Considering the novelty of these technologies, technological developments and funding schemes for these investments are still immature to some extent. For that reason, a comprehensive review of the main aspects of energy planning as well as district heating economics and financing schemes for large-scale investments in renewable energy systems for district energy systems is performed. In the light of digitalization, networks are increasingly monitored, allowing for a drastic change in the approach for network operation. This book also explores the increased digitization and monitoring of networks and how this impacts network operation. This book is of interest to engineers, academics and officials interested in energy systems, presenting readers with the key concepts and tools to adapt to the evolution of district heating into an integrated, digitized and higher performing system.

Surface wind is an essential variable for the study of ocean dynamics. It is one of the main agents responsible for driving ocean surface currents since it is directly related to the generation of mechanisms such as Ekman’s currents. The role of the surface winds is especially relevant in complex coastal areas such as the Gulf of Cadiz (southwestern of the Iberian Peninsula), where the wind field is highly variable in the spatio-temporal domain. Therefore, improving weather models to accurately simulate the wind speed in complex areas is needed for the study of both the ocean and the associated climate variability. Unlike in-situ data from weather stations and buoys, which allow the evaluation of the temporal evolution of the model’s simulations, wind speed from satellite altimetry enable the analysis of the spatial variability of the wind speed along the satellite track over the ocean. This work presents the capabilities of wind speed (WS) retrievals from the altimeters on-board satellites Sentinel-3A/B (S3A/B) for the spatial validation of WS outputs from the Weather Research and Forecasting (WRF) model over the complex coastal area of the Gulf of Cádiz (GoC). In order to assess the applicability of the altimetry data for this purpose, comparisons between three different WS data sources over the GoC area were evaluated: in-situ measurements, S3A/B altimetry data at 20 Hz of posting rate and the WRF model output. Outputs from the WRF model over the area were evaluated with in-situ data, with satisfactory results (WS bias < 0.75 m/s) over the different locations. The spatial variability of the WS derived from the WRF model was compared with the along-track altimetryderived WS. The analysis was carried out under different wind synoptic conditions. Qualitative and quantitative results (average RMSE < 1.0 m/s) proved the agreement between both data sets under low/high wind regimes, proving that the spatial coverage of satellite altimetry enables the spatial validation of high-resolution numerical weather prediction models in water-covered surfaces, including coastal areas. This work aims to fostering the use of altimetry data for improving the knowledge of the wind speed and sea surface circulation over complex areas where the availability of in-situ measurements is limited or inexistent. We have shown how the spatial coverage of satellite altimetry enables the spatial validation of high-resolution NWP models in any water-covered surface of the world, including coastal areas, a feature that sets altimetry apart from any other data source.

El presente estudio tiene como objetivo general determinar la relación entre el Aula Invertida y la Autoeficacia Académica de los estudiantes de la facultad de Derecho de una universidad de Lima en el 2021. Asimismo, determinar la relación entre cada una de las dimensiones del Aula Invertida y el nivel de Autoeficacia Académica. La investigación tiene un enfoque cuantitativo, de tipo aplicada, con un diseño no experimental de corte transversal correlacional. Se trabajó con una muestra conformada por 50 estudiantes del VIII ciclo de la Facultad de Derecho. Se aplicaron dos cuestionarios válidos y confiables. Posteriormente, se desarrollaron los análisis descriptivo e inferencial utilizando el software SPSS 23. Los resultados se mostraron mediante tablas estadísticas y figuras, en los cuales se utilizó la prueba de normalidad de Shapiro Wilk, puesto que se utiliza para muestras menores a 50 sujetos. Los resultados indican que el valor de la significancia es menor a 0.05, lo que permite aplicar la correlación de Spearman para la medición de las relaciones, por lo tanto, se determinó que existe una correlación de 0,541 entre el Aula Invertida y la Autoeficacia Académica. Finalmente, se concluyó que existe una correlación positiva media entre ambas variables. Lima Norte Escuela de Posgrado Evaluación y Aprendizaje Biodiversidad, cambio climático y calidad ambiental Apoyo a la reducción de brechas y carencias en la educación en todos sus niveles Educación de calidad

EEA Valle Inferior Fil: Neffen, Evelyn María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: Zelmer, Hernán Rubén. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: D ónofrio, Mariano Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: Martinez, Roberto Simón. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: Tinture Torrado, Cintia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: Musi, Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina Fil: Musi Saluj, Cristian Ali. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Valle Inferior; Argentina

Background: Venetoclax is a drug that targets BCL-2 protein in cancer cells, first approved for chronic lymphocytic leukemia, this drug has showed efficacy also in acute myeloid leukemia in non-intense chemotherapy candidates in combination with hypomethylating agents as azacitidine and decitabine. This scheme has shown efficiency in acute myeloid leukemia reporting overall response rate (CR) in 61% in untreated elderly patients combined with azacitidine or decitabine. Febrile neutropenia was reported in 30%, thrombocytopenia in 47%, and serious infections in 33%. Hemophagocytic lymphohistiocytosis (HLH) is an uncommon hematologic disorder caused by a proinflammatory state manifested by cytopenias and elevation of acute phase reactants; it is a severe complication of some diseases and to our knowledge it has never been reported secondary to venetoclax plus azacitidine. Early treatment is fundamental for success in HLH. Case series: Three cases of HLH secondary to venetoclax plus azacitidine have appeared in our medical group in patients treated for acute myeloid leukemia. One elderly woman and elderly men with previously untreated acute myeloid leukemia presented HLH with laboratory and bone marrow findings, both responded to dexamethasone plus ruxolitinib. The third case was documented in a male diagnosed with blast phase chronic myeloid leukemia who also responded to dexamethasone plus ruxolitinib. No patient died from HLH. Conclusion: Here we report three cases of patients with HLH after the treatment with azacitidine plus venetoclax. We suspect that the great effect of venetoclax in synergy with azacitidine can liberate enough proinflammatory cytokines in the medullar niche to induce HLH. Early recognition is vital for soon treatment and successful management of this potential complication.