Search

We have synthesized a series of hydrazones and acylhydrazones of naltrexone. These substitutions had modest effects on competition of mu binding but many greatly enhanced the relative potency of the compounds for delta receptors. Increased delta affinity was most prominent with the acylhydrazones. Many of the derivatives elicited a wash-resistant inhibition of binding which was restricted to mu, not delta, binding sites. This wash-resistant inhibition of binding did not correlate with affinity, as determined by IC50 values, implying that the inhibition could not be explained simply by slow rate of dissociation due to increased affinity.

Chronic treatment with opioid antagonists increases the potency of opioid agonists and produces an increase in brain opioid binding sites. In the present study, 8 day treatment with naltrexone blocked morphine and DADLE analgesia for the entire treatment period and increased μ 1 , μ 2 and δ opioid receptor binding sites in mouse brain. μ 1 and μ 2 binding were increased by 81 and 67%, respectively, while δ binding was increased by 31%. Consistent with these binding changes, the potency of ICV morphine to produce analgesia was increased by over 3-fold, while the potency of ICV DADLE was increased by only 1.7. These findings indicate that relative increases in opioid receptor subtypes agree with pharmacodynamic studies on potency changes of opioid agonists.

Patients with Parkinson's syndrome whose major symptoms are akinesis, rigidity, inertia, depression, irritability and failure of adaptation rather than tremor appear to benefit in a global way from therapy with imipramine. Patients without much over-all functional impairment do not show this improvement. The hypothesis is offered that motivation to move and ability to move are perhaps neurologically as well as psychologically related functions.

n/a

n/a

This paper describes the development of a movement based training game aimed at teaching users an exercise program. This is achieved through analysing body posture as the player performs the exercise routine while concurrently receiving real-time feedback from the game. An in-depth post game feedback system also features, giving the player a detailed account of their performance after completing the exercise routine. Analysis of the player’s posture is achieved by placing orientation sensors on appropriate parts of the players’ body. The game can then read and interpret data from these sensors reconstructing a live 3D model of the players’ posture. The game has the kinematic data of an expert performing the current exercise routine stored in memory, which is compared to the kinematic data of the current player and appropriate feedback is given to aid the player in performing the exercise. The theme of the prototype game currently developed is that of a yoga training game (E-Yoga).