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1,657 results on '"Margolis, David J."'

215. Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

Author

Mack, Madison R., primary, Brestoff, Jonathan R., additional, Berrien-Elliott, Melissa M., additional, Trier, Anna M., additional, Yang, Ting-Lin B., additional, McCullen, Matthew, additional, Collins, Patrick L., additional, Niu, Haixia, additional, Bodet, Nancy D., additional, Wagner, Julia A., additional, Park, Eugene, additional, Xu, Amy Z., additional, Wang, Fang, additional, Chibnall, Rebecca, additional, Council, M. Laurin, additional, Heffington, Carrie, additional, Kreisel, Friederike, additional, Margolis, David J., additional, Sheinbein, David, additional, Lovato, Paola, additional, Vivier, Eric, additional, Cella, Marina, additional, Colonna, Marco, additional, Yokoyama, Wayne M., additional, Oltz, Eugene M., additional, Fehniger, Todd A., additional, and Kim, Brian S., additional

Published
2020
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217. A Basophil-Neuronal Axis Promotes Itch

Author

Wang, Fang, primary, Trier, Anna M., additional, Li, Fengxian, additional, Kim, Seonyoung, additional, Chen, Zhen, additional, Chai, Jiani N., additional, Mack, Madison R., additional, Morrison, Stephanie A., additional, Hamilton, Jennifer D., additional, Baek, Jinok, additional, Yang, Ting-Lin B., additional, Ver Heul, Aaron M., additional, Xu, Amy Z., additional, Xie, Zili, additional, Dong, Xintong, additional, Kubo, Masato, additional, Hu, Hongzhen, additional, Hsieh, Chyi-Song, additional, Dong, Xinzhong, additional, Liu, Qin, additional, Margolis, David J., additional, Ardeleanu, Marius, additional, Miller, Mark J., additional, and Kim, Brian S., additional

Published
2020
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220. Evaluating patient-perceived control of atopic dermatitis: design, validation, and scoring of the Atopic Dermatitis Control Tool (ADCT)

Author

Pariser, David M., primary, Simpson, Eric L., additional, Gadkari, Abhijit, additional, Bieber, Thomas, additional, Margolis, David J., additional, Brown, Michelle, additional, Nelson, Lauren, additional, Mahajan, Puneet, additional, Reaney, Matthew, additional, Guillemin, Isabelle, additional, Mallya, Usha G., additional, and Eckert, Laurent, additional

Published
2019
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227. No Association of filaggrin copy number variation and atopic dermatitis risk in White and Black Americans.

Author

Fulton, Rachel L., Margolis, David J., Sockler, Patrick G., Mitra, Nandita, Wong, Xuan Fei Colin Cornelius, and Common, John E.

Subjects
*ATOPIC dermatitis, *FILAGGRIN, *AFRICAN Americans, *ODDS ratio, *RACIAL differences
Abstract

Atopic dermatitis (AD) is a chronic, inflammatory skin condition with a multifactorial pathophysiology. The filaggrin gene (FLG) has particularly been implicated given loss of function (LoF) mutations in this gene lead to skin barrier dysfunction and such mutations can increase a patient's likelihood of developing AD. FLG has intragenic copy number variation (CNV), which impacts the total amount of filaggrin produced. Previous research reported a dose‐dependent effect such that as amount of FLG increases, risk of AD decreases. To gain a better understanding, we evaluated FLG CNV in a large case‐control study of Whites and Blacks with and without AD. The goal of our study was to determine whether FLG CNV has a dose‐dependent effect on the risk of developing AD and to determine whether FLG CNV varies by race. The frequencies and odds ratios comparing a given CNV by race or race within those with AD did not significantly vary. It had been thought that FLG CNV might vary by race and represent an important association with AD in Black AD subjects. However, our work suggests that while there are racial differences with respect to CNV, these differences do not appear to explain AD risk. [ABSTRACT FROM AUTHOR]

Published
2022
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234. Clinical onset of atopic eczema: results from two nationally representative British birth cohorts followed through mid-life

Author

Abubara, Katrina, Ye, Morgan, McCulloch, Charles E., Sullivan, Alice, Margolis, David J., Strachan, David P., Paternoster, Lavinia, Yew, Yik Weng, and Williams, Hywel C.

Subjects
body regions, immune system diseases, Epidemiology, otorhinolaryngologic diseases, Natural history, Atopic eczema, skin and connective tissue diseases, Atopic dermatitis
Abstract

BackgroundAtopic eczema onset is described primarily in early childhood; the frequency and characteristics of adult-onset disease remain controversial.ObjectiveTo determine the proportion of individuals who report atopic eczema symptoms between birth and mid adulthood, and to examine demographic, immunologic, and genetic factors associated with period of symptom onset.MethodsWe conducted a longitudinal study using data from two nationally representative community-based birth cohorts from the United Kingdom: the British Cohort Studies 1958 and 1970. Individuals were followed from birth through age 42-50. The primary outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures of self-reported atopic eczema at each survey wave.ResultsThe annual period prevalence of atopic eczema ranged from 5-15% in two cohorts of over 17,000 participants each followed from birth through mid-age. There was no clear trend in prevalence by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom onset reported in childhood. When compared with individuals whose eczema started in childhood, those with adult-onset disease were more likely to be women, from Scotland or Northern England, of lower childhood socio-economic group, smokers in adulthood, and less likely to have a history of asthma. In a sub-analysis using data from the 1958 cohort only, genetic mutations previously associated with atopic eczema, including filaggrin null mutations, and allergen-specific IgE were more common among those with childhood-onset disease.ConclusionRates of self-reported atopic eczema remain high after childhood, and adult-onset atopic eczema has different risk factor associations than childhood-onset eczema.

Published
2019

235. Clinical onset of atopic eczema:Results from 2 nationally representative British birth cohorts followed through midlife

Author

Abuabara, Katrina, Ye, Morgan, McCulloch, Charles E, Sullivan, Alice, Margolis, David J, Strachan, David P, Paternoster, Lavinia, Yew, Yik Weng, Williams, Hywel C, and Langan, Sinéad M

Subjects
Adult, Male, Adolescent, Allergy, Immunology, atopic eczema, Dermatitis, Filaggrin Proteins, Article, Atopic, Dermatitis, Atopic, Cohort Studies, Young Adult, Clinical Research, 2.3 Psychological, immune system diseases, otorhinolaryngologic diseases, Humans, 2.1 Biological and endogenous factors, Longitudinal Studies, Aetiology, skin and connective tissue diseases, Child, Preschool, Skin, FLG, Filaggrin, Pediatric, BCS, British Cohort Study, atopic dermatitis, Prevention, Infant, Newborn, Infant, Middle Aged, Newborn, body regions, England, natural history, Child, Preschool, UK, United Kingdom, Atopic eczema, Female, epidemiology, Self Report, social and economic factors, OR, Odds ratio, 2.4 Surveillance and distribution
Abstract

Background Atopic eczema onset is described primarily in early childhood, and the frequency and characteristics of adult-onset disease remain controversial. Objective We sought to determine the proportion of subjects who report atopic eczema symptoms between birth and midadulthood and to examine demographic, immunologic, and genetic factors associated with period of symptom onset. Methods We conducted a longitudinal study using data from 2 nationally representative community-based birth cohorts from the United Kingdom: the British Cohort Studies 1958 and 1970. Subjects were followed from birth through age 42 to 50 years. The primary outcome was the age period of self-reported atopic eczema symptom onset based on repeated measures of self-reported atopic eczema at each survey wave. Results The annual period prevalence of atopic eczema ranged from 5% to 15% in 2 cohorts of more than 17,000 participants each followed from birth through middle age. There was no clear trend in prevalence by age, and among adults reporting active atopic eczema during a given year, only 38% had symptom onset reported in childhood. When compared with subjects whose eczema started in childhood, those with adult-onset disease were more likely to be women, from Scotland or Northern England, of lower childhood socioeconomic group, smokers in adulthood, and less likely to have a history of asthma. In a subanalysis using data from the 1958 cohort only, genetic mutations previously associated with atopic eczema, including filaggrin-null mutations, and allergen-specific IgE were more common among those with childhood-onset disease. Conclusion Rates of self-reported atopic eczema remain high after childhood, and adult-onset atopic eczema has different risk factor associations than childhood-onset eczema., Graphical abstract

Published
2019

236. Exome Sequencing and Rare Variant Analysis Reveals Multiple Filaggrin Mutations in Bangladeshi Families with Atopic Eczema and Additional Risk Genes

Author

Pigors, Manuela, Common, John E.A., Wong, Xuan Fei Colin C., Malik, Sajid, Scott, Claire A., Tabarra, Niloofar, Liany, Herty, Liu, Jianjun, Limviphuvadh, Vachiranee, Maurer-Stroh, Sebastian, Tang, Mark B.Y., Lench, Nicholas, Margolis, David J., van Heel, David A., Mein, Charles A., Novak, Natalija, Baurecht, Hansjörg, Weidinger, Stephan, McLean, W.H. Irwin, Irvine, Alan D., O’Toole, Edel A., Simpson, Michael A., and Kelsell, David P.

Published
2018
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240. Association between the use of (beta)-adrenergic receptor agents and the development of venous leg ulcers

Author

Margolis, David J., Hoffstad, Ole, and Isseroff, R. Rivkah

Subjects
Adrenergic beta agonists -- Dosage and administration, Adrenergic beta agonists -- Physiological aspects, Adrenergic beta agonists -- Research, Adrenergic beta blockers -- Dosage and administration, Adrenergic beta blockers -- Physiological aspects, Adrenergic beta blockers -- Research, Leg -- Ulcers, Leg -- Development and progression, Leg -- Care and treatment, Health
Published
2007

249. Guidelines of care for atopic dermatitis

Author

Hanifin, Jon M, Cooper, Kevin D, Ho, Vincent C, Kang, Sewon, Krafchik, Bernice R, Margolis, David J, Schachner, Lawrence A, Sidbury, Robert, Whitmore, Susan E, Sieck, Carol K, and Van Voorhees, Abby S

Published
2004
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