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1,163 results on '"Mara, Kristin"'

206. Incidence and risk of attention-deficit/hyperactivity disorder and learning disability by adulthood after traumatic brain injury in childhood: a population-based birth cohort study.

Author

Brown, Allen W., Esterov, Dmitry, Zielinski, Martin D., Weaver, Amy L., Mara, Kristin C., Ferrara, Michael J., Immermann, Joseph M., and Moir, Christopher

Subjects
LEARNING disabilities, BRAIN injuries, ATTENTION-deficit hyperactivity disorder, COHORT analysis, ADULTS
Abstract

The aim of this study was to understand the risk of developing attention-deficit/hyperactivity disorder (ADHD) or learning disability (LD) after childhood traumatic brain injury (TBI) in a population-based birth cohort. Cases of TBI for children from birth to 10 years were confirmed and stratified by severity of injury. For each TBI case, two age-matched and sex-matched referents without TBI were identified from the same birth cohort. Presence of ADHD and LD before age 19 were confirmed using medical and/or school records. Associations between TBI exposure and subsequent ADHD or LD were assessed in multivariable Cox regression models, adjusting for maternal age, education, and race. The incidence rate of TBI before age 10 was 1,156 per 100,000 person-years. Children who had a TBI before age 10 were more likely to have met the research criteria for ADHD (hazard ratio [HR], 1.68; 95% CI, 1.15–2.45) or LD (HR, 1.29; 95% CI, 1.00–1.68) by age 19. No statistically significant associations were shown between TBI and ADHD or LD when restricted to definite and probable TBI cases (consistent with moderate to severe and mild TBI, respectively) and their referents. Significant associations were shown when the analysis was confined to possible TBI cases (consistent with concussive TBI) and their referents (ADHD: HR, 2.05; 95% CI, 1.31–3.20; and LD: HR, 1.42; 95% CI, 1.05–1.91). Increased risk for developing ADHD and LD by adulthood was shown particularly for children with the least-severe injuries, indicating that factors other than trauma-related altered brain function likely contribute to this risk. [ABSTRACT FROM AUTHOR]

Published
2023
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207. Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support.

Author

Wieruszewski, Patrick M., Seelhammer, Troy G., Barreto, Erin F., Busse, Laurence W., Chow, Jonathan H., Davison, Danielle L., Gaglani, Bhavita, Khanna, Ashish K., ten Lohuis, Caitlin C., Mara, Kristin C., and Wittwer, Erica D.

Subjects
ANGIOTENSIN II, HYPOTENSION, VASOCONSTRICTORS, ARTERIAL pressure, HEALTH outcome assessment, VASOPRESSIN
Abstract

Background: Patients supported on mechanical circulatory support devices experience vasodilatory hypotension due to high surface area exposure to nonbiological and non-endothelialized surfaces. Angiotensin II has been studied in general settings of vasodilatory shock, however concerns exist regarding the use of this vasopressor in patients with pre-existing cardiac failure. The objective of this study was to assess the systemic and central hemodynamic effects of angiotensin II in patients with primary cardiac or respiratory failure requiring treatment with mechanical circulatory support devices. Methods: Multicenter retrospective observational study of adults supported on a mechanical circulatory support device who received angiotensin II for vasodilatory shock. The primary outcome was the intraindividual change from baseline in mean arterial pressure (MAP) and vasopressor dosage after angiotensin II. Results: Fifty patients were included with mechanical circulatory devices that were primarily used for cardiac failure (n = 41) or respiratory failure (n = 9). At angiotensin II initiation, the norepinephrine equivalent vasopressor dosage was 0.44 (0.34, 0.64) and 0.47 (0.33, 0.73) mcg/kg/min in the cardiac and respiratory groups, respectively. In the cardiac group, MAP increased from 60 to 70 mmHg (intraindividual P <.001) in the 1 h after angiotensin II initiation and the vasopressor dosage declined by 0.04 mcg/kg/min (intraindividual P <.001). By 12 h, the vasopressor dosage declined by 0.16 mcg/kg/min (P =.001). There were no significant changes in cardiac index or mean pulmonary artery pressure throughout the 12 h following angiotensin II. In the respiratory group, similar but nonsignificant effects at 1 h on MAP (61-81 mmHg, P =.26) and vasopressor dosage (decline by 0.13 mcg/kg/min, P =.06) were observed. Conclusions: In patients requiring mechanical circulatory support for cardiac failure, angiotensin II produced beneficial systemic hemodynamic effects without negatively impacting cardiac function or pulmonary pressures. The systemic hemodynamic effects in those with respiratory failure were nonsignificant due to limited sample size. [ABSTRACT FROM AUTHOR]

Published
2023
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209. Reply

Author

Gidener, Tolga, primary, Dierkhising, Ross, additional, Mara, Kristin C., additional, Therneau, Terry M., additional, Venkatesh, Sudhakar K., additional, Ehman, Richard L., additional, Yin, Meng, additional, and Allen, Alina M., additional

Published
2022
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222. Procalcitonin As a Biomarker for Prediction of Bacterial Infection in Patients Receiving Chimeric Antigen Receptor T-Cell Therapy

Author

Powell, Marissa Z, primary, Mara, Kristin, additional, Bansal, Radhika, additional, Hathcock, Matthew, additional, Khurana, Arushi, additional, Bennani, Nora N, additional, Wang, Yucai, additional, Paludo, Jonas, additional, Villasboas, Jose C, additional, Ansell, Stephen, additional, Johnston, Patrick B, additional, Lin, Yi, additional, and Barreto, Jason N, additional

Published
2022
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225. sj-docx-1-jic-10.1177_08850666221145864 - Supplemental material for Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support

Author

Wieruszewski, Patrick M., Seelhammer, Troy G., Barreto, Erin F., Busse, Laurence W., Chow, Jonathan H., Davison, Danielle L., Gaglani, Bhavita, Khanna, Ashish K., ten Lohuis, Caitlin C., Mara, Kristin C., and Wittwer, Erica D.

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110305 Emergency Medicine
Abstract

Supplemental material, sj-docx-1-jic-10.1177_08850666221145864 for Angiotensin II for Vasodilatory Hypotension in Patients Requiring Mechanical Circulatory Support by Patrick M. Wieruszewski, Troy G. Seelhammer, Erin F. Barreto, Laurence W. Busse, Jonathan H. Chow, Danielle L. Davison, Bhavita Gaglani, Ashish K. Khanna, Caitlin C. ten Lohuis, Kristin C. Mara and Erica D. Wittwer in Journal of Intensive Care Medicine

Published
2022
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226. sj-docx-1-cat-10.1177_10760296221124902 - Supplemental material for Safety Comparison of Monotherapy Aspirin to Dual Antiplatelet Therapy Following Coronary Artery Bypass Surgery

Author

Nei, Scott D., Wamsley, Kyle S., Mara, Kristin C., Stulak, John M., and Zieminski, Joseph J.

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-1-cat-10.1177_10760296221124902 for Safety Comparison of Monotherapy Aspirin to Dual Antiplatelet Therapy Following Coronary Artery Bypass Surgery by Scott D. Nei, Kyle S. Wamsley, Kristin C. Mara, John M. Stulak and Joseph J. Zieminski in Clinical and Applied Thrombosis/Hemostasis

Published
2022
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227. sj-pdf-1-pev-10.1177_22840265221093262 – Supplemental material for Gastrointestinal symptoms as a predictor of deep endometriosis of the pelvic posterior compartment on magnetic resonance imaging

Author

Fadadu, Priyal Praful, Cope, Adela, Weng, Chia-Sui, Mara, Kristin, Khan, Zaraq, VanBuren, Wendaline, and Burnett, Tatnai

Subjects
body regions, FOS: Clinical medicine, fungi, 111402 Obstetrics and Gynaecology
Abstract

Supplemental material, sj-pdf-1-pev-10.1177_22840265221093262 for Gastrointestinal symptoms as a predictor of deep endometriosis of the pelvic posterior compartment on magnetic resonance imaging by Priyal Praful Fadadu, Adela Cope, Chia-Sui Weng, Kristin Mara, Zaraq Khan, Wendaline VanBuren and Tatnai Burnett in Journal of Endometriosis and Pelvic Pain Disorders

Published
2022
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239. The Natural History of Nonalcoholic Fatty Liver Disease with Normal Body Mass Index: a Population-Based Study: Long Term Outcomes in Lean NAFLD

Author

Ahmed, Omar T., Gidener, Tolga, Mara, Kristin C., Larson, Joseph J., Therneau, Terry M., and Allen, Alina M.

Subjects
Adult, Liver Cirrhosis, Cardiovascular Diseases, Non-alcoholic Fatty Liver Disease, Risk Factors, Humans, Female, Obesity, Overweight, Fibrosis, Article, Body Mass Index
Abstract

The natural history of lean nonalcoholic fatty liver disease (NAFLD) is not well-understood. Consequently, patient counseling and disease management are limited. We aimed to compare the natural history of lean, overweight, and obese NAFLD in a U.S. population with long-term follow-up.All adults diagnosed with NAFLD in Olmsted County, MN between 1996 and 2016 were identified, and all subsequent medical events were ascertained using a medical record linkage system. Subjects were divided on the basis of body mass index (BMI) at NAFLD diagnosis into 3 groups: normal, overweight, and obese. The probability to develop cirrhosis, decompensation, malignancies, cardiovascular events, or death among the 3 groups was estimated by using the Aalen-Johansen method, treating death as a competing risk. The impact of BMI categories on these outcomes was explored by using Cox proportional hazards regression analysis.A total of 4834 NAFLD individuals were identified: 414 normal BMI, 1189 overweight, and 3231 obese. Normal BMI NAFLD individuals were characterized by a higher proportion of women (66% vs 47%) and lower prevalence of metabolic comorbidities than the other 2 groups. In reference to obese, those with normal BMI NAFLD had a nonsignificant trend toward lower risk of cirrhosis (hazard ratio [HR], 0.33, 95% confidence interval [CI], 0.1-1.05). There were no significant differences in the risk of decompensation (HR, 0.79; 95% CI, 0.11-5.79), cardiovascular events (HR, 1.05; 95% CI, 0.73-1.51), or malignancy (HR, 0.87; 95% CI, 0.51-1.48). Compared with obese, normal BMI NAFLD had higher risk of all-cause mortality (HR, 1.96; 95% CI, 1.52-2.51).NAFLD with normal BMI is associated with a healthier metabolic profile and possibly a lower risk of liver disease progression but similar risk of cardiovascular disease and malignancy than obese NAFLD.

Published
2021

246. Prospective evaluation of high‐dose methotrexate pharmacokinetics in adult patients with lymphoma using novel determinants of kidney function

Author

Barreto, Jason N., primary, Reid, Joel M., additional, Thompson, Carrie A., additional, Mara, Kristin C., additional, Rule, Andrew D., additional, Kashani, Kianoush B., additional, Leung, Nelson, additional, Larson, Thomas R., additional, McGovern, Renee M., additional, Witzig, Thomas E., additional, and Barreto, Erin F., additional

Published
2021
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249. Automated Analysis of Multi-parametric MRI/MRE Exams for prediction of NASH

Author

Dzyubak, Bogdan, Li, Jiahui, Chen, Jie, Mara, Kristin C., Therneau, Terry M., Venkatesh, Sudhakar K., Ehman, Richard L., Allen, Alina M., and Yin, Meng

Subjects
Liver, Non-alcoholic Fatty Liver Disease, Elasticity Imaging Techniques, Humans, Prospective Studies, Multiparametric Magnetic Resonance Imaging, Magnetic Resonance Imaging, Article
Abstract

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global population. The standard of diagnosis, biopsy, is invasive and affected by sampling error and inter-reader variability. We hypothesized that widely available rapid MRI techniques could be used to predict nonalcoholic steatohepatitis (NASH) non-invasively by measuring liver stiffness, with magnetic resonance elastography (MRE), and liver fat, with chemical shift-encoded (CSE) MRI. Besides, we validate an automated image analysis technique to maximize the utility of these methods. PURPOSE: To implement and test an automated system for analyzing CSE-MRI and MRE data coupled with model-based prediction of NASH. STUDY TYPE: Prospective. SUBJECTS: 83 patients with suspected NAFLD. FIELD STRENGTH/SEQUENCE: 1.5 T using a flow-compensated motion-encoded gradient echo MRE sequence and a multi-echo CSE-MRI sequence. ASSESSMENTS: The MRE and CSE-MRI data were analyzed by two readers (5+ and 1 years of experience) and an automated algorithm. A logistic regression model to predict pathology-diagnosed NASH was trained based on stiffness and proton density fat fraction, and the area under the receiver operating characteristic curve (AUROC) was calculated using 10-fold cross validation for models based on both automated and manual measurements. A separate model was trained to predict the NASH severity score (NAS). STATISTICAL TESTS: Pearson’s correlation, Bland-Altman, AUROC, C-statistic. RESULTS: The agreement between automated measurements and the more experienced reader (R(2) = 0.87 for stiffness and R(2) = 0.99 for PDFF) was slightly better than the agreement between readers (R(2) = 0.85 and 0.98). The model for predicting biopsy-diagnosed NASH had an AUROC of 0.87. The NAS-prediction model had a C-statistic of 0.85. DATA CONCLUSION: We demonstrated a workflow that used a limited MRI acquisition protocol and fully automated analysis to predict NASH with high accuracy. These methods show promise to provide a reliable noninvasive alternative to biopsy for NASH-screening in populations with NAFLD.

Published
2021

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