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1,098 results on '"Makino, Hiroshi"'

202. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota

Author

Martin, Rocio, primary, Makino, Hiroshi, additional, Cetinyurek Yavuz, Aysun, additional, Ben-Amor, Kaouther, additional, Roelofs, Mieke, additional, Ishikawa, Eiji, additional, Kubota, Hiroyuki, additional, Swinkels, Sophie, additional, Sakai, Takafumi, additional, Oishi, Kenji, additional, Kushiro, Akira, additional, and Knol, Jan, additional

Published
2016
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204. Hidden Disease with Pulmonary Alveolar Hemorrhage

Author

Saraya, Takeshi, primary, Tsujimoto, Naoki, additional, Yamada, Yoshifumi, additional, Nunokawa, Hiroki, additional, Ohkuma, Kosuke, additional, Yonetani, Shota, additional, Makino, Hiroshi, additional, Araki, Koji, additional, Tsukahara, Yayoi, additional, Fujiwara, Masachika, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2016
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205. The assessing the left bronchial invasion of esophageal cancer in computed tomography

Author

Makino, Hiroshi, primary, Yoshida, Hiroshi, additional, Maruyama, Hiroshi, additional, Yokoyama, Tadashi, additional, Hirakata, Atsushi, additional, Ueda, Jyunji, additional, Takada, Hideyuki, additional, Kikuchi, Yuta, additional, Shinozuka, Eriko, additional, Miyashita, Masao, additional, Matsutani, Takeshi, additional, Nomura, Tsutomu, additional, and Uchida, Eiji, additional

Published
2016
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213. Characteristics predicting laparoscopic skill in medical students: nine years' experience in a single center.

Author

Nomura, Tsutomu, Matsutani, Takeshi, Hagiwara, Nobutoshi, Fujita, Itsuo, Nakamura, Yoshiharu, Kanazawa, Yoshikazu, Makino, Hiroshi, Mamada, Yasuhiro, Fujikura, Terumichi, Miyashita, Masao, and Uchida, Eiji

Subjects
LAPAROSCOPIC surgery, ENDOSCOPIC surgery, LAPAROSCOPY, MEDICAL students, SURGERY, CLINICAL competence, COMPUTER simulation, MEDICAL education
Abstract

Introduction: We introduced laparoscopic simulator training for medical students in 2007. This study was designed to identify factors that predict the laparoscopic skill of medical students, to identify intergenerational differences in abilities, and to estimate the variability of results in each training group. Our ultimate goal was to determine the optimal educational program for teaching laparoscopic surgery to medical students.Methods: Between 2007 and 2015, a total of 270 fifth-year medical students were enrolled in this observational study. Before training, the participants were asked questions about their interest in laparoscopic surgery, experience with playing video games, confidence about driving, and manual dexterity. After the training, aspects of their competence (execution time, instrument path length, and economy of instrument movement) were assessed.Results: Multiple regression analysis identified significant effects of manual dexterity, gender, and confidence about driving on the results of the training. The training results have significantly improved over recent years. The variability among the results in each training group was relatively small.Conclusions: We identified the characteristics of medical students with excellent laparoscopic skills. We observed educational benefits from interactions between medical students within each training group. Our study suggests that selection and grouping are important to the success of modern programs designed to train medical students in laparoscopic surgery. [ABSTRACT FROM AUTHOR]

Published
2018
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216. Bright, color-tunable fluorescent dyes in the visible-near-infrared region

Author

Umezawa, Keitaro, Nakamura, Yuki, Makino, Hiroshi, Citterio, Daniel, and Suzuki, Koji

Subjects
Organic dyes -- Research, Organic dyes -- Chemical properties, Near infrared spectroscopy -- Usage, Chemistry
Abstract

The design and synthesis of boron-difuropyromethene fluorescent dyes named Keio Fluors (KFL) are described. The results have shown that the KFL has the potential to substitute or to complement the existing fluorescent dyes and to be used as new standard dyes in the visible-near infrared region.

Published
2008

218. The Comprehensive Analysis of PI3K/AKT Pathway and miRNAs in Esophageal Squamous Cell Carcinoma

Author

Akagi, Ichiro, primary, Matsutani, Takeshi, additional, Ishibashi, Osamu, additional, Makino, Hiroshi, additional, Yoshida, Hiroshi, additional, Nomura, Tsutomu, additional, Hagiwara, Nobutoshi, additional, Maruyama, Hiroshi, additional, Yokoyama, Tadashi, additional, Hirakata, Atsushi, additional, Ueda, Junji, additional, Miyashita, Masao, additional, and Uchida, Eiji, additional

Published
2015
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226. IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment

Author

Kinose, Yasuto, primary, Sawada, Kenjiro, additional, Makino, Hiroshi, additional, Ogura, Tomonori, additional, Mizuno, Tomoko, additional, Suzuki, Noriko, additional, Fujikawa, Tomoyuki, additional, Morii, Eiichi, additional, Nakamura, Koji, additional, Sawada, Ikuko, additional, Toda, Aska, additional, Hashimoto, Kae, additional, Isobe, Aki, additional, Mabuchi, Seiji, additional, Ohta, Tsuyoshi, additional, Itai, Akiko, additional, Morishige, Ken-ichirou, additional, Kurachi, Hirohisa, additional, and Kimura, Tadashi, additional

Published
2015
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227. Interleukin 6 Receptor Is an Independent Prognostic Factor and a Potential Therapeutic Target of Ovarian Cancer

Author

Isobe, Aki, primary, Sawada, Kenjiro, additional, Kinose, Yasuto, additional, Ohyagi-Hara, Chifumi, additional, Nakatsuka, Erika, additional, Makino, Hiroshi, additional, Ogura, Tomonori, additional, Mizuno, Tomoko, additional, Suzuki, Noriko, additional, Morii, Eiichi, additional, Nakamura, Koji, additional, Sawada, Ikuko, additional, Toda, Aska, additional, Hashimoto, Kae, additional, Mabuchi, Seiji, additional, Ohta, Tsuyoshi, additional, Morishige, Ken-ichirou, additional, Kurachi, Hirohisa, additional, and Kimura, Tadashi, additional

Published
2015
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228. Reversed halo sign caused by huge tricuspid native valve infective endocarditis associated with community-acquired methicillin-resistant Staphylococcus aureus

Author

Saraya, Takeshi, primary, Kikuchi, Ken, additional, Araki, Koji, additional, Uehara, Yuki, additional, Makino, Hiroshi, additional, Tamura, Masaki, additional, Hirukawa, Ichiro, additional, Honda, Kojiro, additional, Yokoyama, Takuma, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, Fujiwara, Masachika, additional, Takizawa, Hajime, additional, and Goto, Hajime, additional

Published
2015
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235. Roles of Estrogen in the Formation of Intracranial Aneurysms in Ovariectomized Female Mice

Author

Tada, Yoshiteru, primary, Makino, Hiroshi, additional, Furukawa, Hajime, additional, Shimada, Kenji, additional, Wada, Kosuke, additional, Liang, Elena I., additional, Murakami, Shoko, additional, Kudo, Mari, additional, Kung, David K., additional, Hasan, David M., additional, Kitazato, Keiko T., additional, Nagahiro, Shinji, additional, Lawton, Michael T., additional, and Hashimoto, Tomoki, additional

Published
2014
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237. A case of sigmoid colon adenocarcinoma diagnosed as facial cutaneous metastasis for survival after operation for 37 months.

Author

Ueda, Junji, Yoshida, Hiroshi, Makino, Hiroshi, Maruyama, Hiroshi, Yokoyama, Tadashi, Hirakata, Atsushi, Takata, Hideyuki, Seki, Natsuki, Kikuchi, Yuta, and Uchida, Eiji

Abstract

Cutaneous metastasis of an internal malignancy is uncommon and is estimated to occur in 0.7-9% of patients with internal cancer including autopsy cases. We would like to report a case of long survival of sigmoid colon adenocarcinoma diagnosed as an instance of facial cutaneous metastasis. A 68-year-old male was admitted to our hospital for a tumor mass on the left side of his cheek. In his past history, acute myocardial infarction had occurred 2 years earlier. He also had chronic renal failure and chronic obstructive pulmonary disease. Histologic findings from the biopsy sample of this facial lesion were moderately differentiated adenocarcinoma. Colonoscopy revealed a tumor 20 mm × 30 mm in diameter in the sigmoid colon. Histologic findings of the biopsy sample of this tumor also indicated moderately differentiated adenocarcinoma. The patient was diagnosed with sigmoid colon cancer with cutaneous metastasis to the face. We performed a sigmoidectomy with lymph node dissection and resection of the facial cutaneous metastasis. After being discharged, low dose chemotherapy was performed in consideration of the patient's renal function. Although long-term management of his general condition was provided, the patient died 37 months after surgery because of chronic heart failure. [ABSTRACT FROM AUTHOR]

Published
2017
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238. Evaluation of pre-surgical models for uterine surgery by use of three-dimensional printing and mold casting.

Author

Sayed Aluwee, Sayed, Zhou, Xiangrong, Kato, Hiroki, Makino, Hiroshi, Muramatsu, Chisako, Hara, Takeshi, Matsuo, Masayuki, and Fujita, Hiroshi

Abstract

We propose an approach to supporting pre-surgical planning for the uterus by integrating medical image analysis and physical model generation based on 3D printing. With our method, we first segment the patient-specific anatomy and lesions of the uterus on MR images; then, we create a 3D physical model, an exact replica of the patient's uterus in terms of size and softness, with transparency for easy observation of the internal structures of the uterus. In our experiments, we created pre-surgical models of hysterectomy for five patients who had been diagnosed to have uterine endometrial cancer. An experienced radiologist, the surgeons, and all of the patients cooperated in our experiment for carrying out subjective evaluations of the usefulness of our model. The accuracy of the physical models was evaluated quantitatively by comparison between the MR images of the patients and the CT images of the models. The results showed that the mean values of the errors in gap ranged from 1.19 to 2.22 mm, which was satisfactory for the surgeons. The feedback from both surgeons and patients demonstrated the usefulness and convenience of the models for efficient patient explanation understanding and pre-surgical planning by surgeons. [ABSTRACT FROM AUTHOR]

Published
2017
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239. Management of ovarian hyperstimulation syndrome with abdominal compartment syndrome, based on intravesical pressure measurement.

Author

Makino, Hiroshi, Furui, Tatsuro, Shiga, Tomomi, Takenaka, Motoki, Terazawa, Keiko, and Morishige, Ken‐ichiro

Subjects
*OVARIAN hyperstimulation syndrome, *INTRA-abdominal hypertension, *CYSTOMETRY, *ASCITIC fluids, *DISEASES in older women, *THERAPEUTICS
Abstract

There are few reports on abdominal compartment syndrome that are caused by ovarian hyperstimulation syndrome (OHSS). Here, a case of a 29 year old woman is reported in which intravesical pressure measurement was useful in the management of severe OHSS that had been complicated by abdominal compartment syndrome. The patient's urinary output and general condition did not improve after the initial treatment. The woman's intra-abdominal pressure was evaluated indirectly, based on her intravesical pressure, and was found to be significantly elevated. The patient's urinary volume increased after a 14 mm Hg decrease in the intravesical pressure was achieved by the drainage of ascitic fluid. Intravesical pressure measurement was useful in the management of the general condition of this patient with OHSS. [ABSTRACT FROM AUTHOR]

Published
2017
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240. Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.

Author

Kato, Hiroki, Matsuo, Masayuki, Hatano, Yuichiro, Makino, Hiroshi, Furui, Tatsuro, and Morishige, Ken-ichirou

Subjects
RENAL cell carcinoma, OVARIES, HISTOPATHOLOGY, OVARIAN cancer diagnosis, ENDOMETRIOSIS, FIBROMAS, MAGNETIC resonance imaging, DIAGNOSIS
Abstract

Purpose: To retrospectively compare the MR findings of histological subtypes of clear cell carcinomas (CCCs) of the ovary. Materials and methods: This single-center retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. Between April 2005 and August 2015, we found 51 consecutive patients with histopathologically proven CCCs. Among them, 44 CCCs in 37 patients who underwent preoperative MR imaging were included. CCCs were pathologically divided into three subgroups: (1) four clear cell adenofibroma-associated CCCs, (2) 21 endometriosis-associated CCCs, and (3) 19 indeterminate CCCs. The statistical tests were used to compare the frequency of qualitative assessments and value of quantitative measurements among the histological subtypes. Results: On T2-weighted images, hypointense areas within solid components were more frequently observed in clear cell adenofibroma-associated CCCs [3/4 (75%)] than in the remaining CCCs [1/40 (3%)] ( p < 0.01), and the signal intensity ratios (SIRs) of solid components were significantly lower in clear cell adenofibroma-associated CCCs (0.27 ± 0.13) than in the remaining CCCs (0.61 ± 0.18) ( p < 0.01). On T1-weighted images, hyperintensities of cystic components were more frequently observed in the endometriosis-associated CCCs [17/21 (81%)] than in the remaining CCCs [5/20 (25%)] ( p < 0.01), and the SIRs of cystic components were significantly higher in endometriosis-associated CCCs (2.99 ± 1.51) than in the remaining CCCs (1.82 ± 1.10) ( p < 0.01). Conclusion: MR features may help differentiate between adenofibroma-associated and endometriosis-associated CCC. [ABSTRACT FROM AUTHOR]

Published
2016
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246. Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC

Author

Saraya, Takeshi, primary, Tanabe, Koichi, additional, Araki, Koji, additional, Yonetani, Shota, additional, Makino, Hiroshi, additional, Watanabe, Takayasu, additional, Tsujimoto, Naoki, additional, Takata, Saori, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, Miyazaki, Yoshitsugu, additional, Takizawa, Hajime, additional, and Goto, Hajime, additional

Published
2014
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247. Estrogen Protects Against Intracranial Aneurysm Rupture in Ovariectomized Mice

Author

Tada, Yoshiteru, primary, Wada, Kosuke, additional, Shimada, Kenji, additional, Makino, Hiroshi, additional, Liang, Elena I., additional, Murakami, Shoko, additional, Kudo, Mari, additional, Shikata, Fumiaki, additional, Pena Silva, Ricardo A., additional, Kitazato, Keiko T., additional, Hasan, David M., additional, Kanematsu, Yasuhisa, additional, Nagahiro, Shinji, additional, and Hashimoto, Tomoki, additional

Published
2014
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