702 results on '"Macchiarulo, Antonio"'
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202. Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation
203. Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands
204. Ligand Binding and Functional Selectivity of l-Tryptophan Metabolites at the Mouse Aryl Hydrocarbon Receptor (mAhR)
205. AhR-Mediated, Non-Genomic Modulation of IDO1 Function
206. Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoid‐induced leucine zipper? A perspective
207. Mo1915 Novel Wnt-Targeted Therapy Inhibitors for Hepatocellular Carcinoma
208. Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors
209. Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery
210. Prediction of enantiomeric selectivity in the chiral ligand-exchange chromatography of amino acids
211. Design and synthesis of 4H-thieno[2,3-c]isoquinolin-5-one derivatives as potent PARP-1 inhibitors, on route of new antiischemic agents
212. Rat brain guanosine binding site. Biological studies and pseudo-Receptor construction
213. PARP-1 and its inhibitors: molecular modeling studies
214. Towards New Neuroprotective Agents: Design and Synthesis of Thieno[2,3-c]-isoquinolinon-5-one as a Potent PARP-1 Inhibitor
215. From Polypharmacology to Target Specificity: The Case of PARP Inhibitors
216. Structure of Metal-Carbenoid Intermediates Derived from the Dirhodium(II)Tetracarboxylate Mediated Decomposition of ?-Diazocarbonyl Compounds. An ab initio and DTF Study
217. Glucocorticoid Induced Leucine Zipper (GILZ) inhibits the RAF-ERK pathway by binding to RAF-1
218. Spiro[2.2]pentane as a dyssymetric scaffold for conformationally constrained analogues of glutamic acid: diastereodivergent synthesis of 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids
219. Homology Modelling of AMPA Receptors: Route to the Identification of Noncompetitive Antagonists Binding Site
220. Molecular determinats for metabotropic glutamate receptor activation and blockade. Molecular dynamics and electrostatic potential analysis studies
221. New potent and selective mGluR1 competitive antagonists: pharmacological characterization and their exploitation in molecular modeling of receptor blocking
222. Exploring the Molecular Dasis of the Selectivity in Metabotropic Glutamate Receptors (mGluRs)
223. Metabotropic Glutamate Receptors: Targets for Therapy of Cerebral Ischemia
224. Modeling of Poly(ADP-ribose)polymerase (PARP) Inhibitors. Docking of Ligands and QSAR
225. QSAR and Molecular Modeling Studies of Baclofen Analogues as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding Activation
226. Probing the Binding Site of Bile Acids in TGR5
227. Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives
228. Navigations of chemical space to further the understanding of polypharmacology in human nuclear receptors
229. Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain
230. Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors.
231. Patented TGR5 modulators: a review (2006 – present)
232. Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors
233. Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
234. Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators
235. From Molecular Docking to 3D‐Quantitative Structure‐Activity Relationships (3D‐QSAR): Insights into the Binding Mode of 5‐Lipoxygenase Inhibitors
236. Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage
237. Divergent and stereoselective synthesis of dafachronic acids
238. Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon?
239. Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)
240. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ
241. Novel Polymorphisms of Nuclear Receptor SHP Associated with Functional and Structural Changes
242. Molecular Interaction Fields and 3D-QSAR Studies of p53−MDM2 Inhibitors Suggest Additional Features of Ligand−Target Interaction
243. ChemInform Abstract: Design, Synthesis and Preliminary Evaluation of Novel 3′-Substituted Carboxycyclopropylglycines (XIV) as Antagonists at Group 2 Metabotropic Glutamate Receptors.
244. Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition
245. Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
246. Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif
247. Mapping Human Metabolic Pathways in the Small Molecule Chemical Space
248. TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
249. Bulky 1,4-benzoxazine derivatives with antifungal activity
250. Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure
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