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1,342 results on '"MacGregor G"'

236. Sputum proteomics in inflammatory and suppurative respiratory diseases.

Author

Gray RD, MacGregor G, Noble D, Imrie M, Dewar M, Boyd AC, Innes JA, Porteous DJ, Greening AP, Gray, Robert D, MacGregor, Gordon, Noble, Donald, Imrie, Margaret, Dewar, Maria, Boyd, A Christopher, Innes, J Alastair, Porteous, David J, and Greening, Andrew P

Abstract

Rationale: Markers of inflammatory activity are important for assessment and management of many respiratory diseases. Markers that are currently unrecognized may be more valuable than those presently believed to be useful.Objectives: To identify potential biomarkers of suppurative and inflammatory lung disease in induced sputum samples.Methods: Induced sputum was collected from 20 healthy control subjects, 24 patients with asthma, 24 with chronic obstructive pulmonary disease, 28 with cystic fibrosis (CF), and 19 with bronchiectasis. Twelve patients with CF had sputum sampled before and after antibiotic therapy for an infective exacerbation. The fluid phase of induced sputum was analyzed by surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectroscopy on three protein array surfaces. Some protein markers were selected for identification, and relevant ELISA assays sought. For 12 patients with CF, both SELDI-TOF and ELISA monitored changes in inflammatory responses during infective exacerbations.Measurements and Main Results: SELDI-TOF identified potential biomarkers that differentiated each of the disease groups from healthy control subjects: at a significance of P < 0.01, there were 105 for asthma, 113 for chronic obstructive pulmonary disease, 381 for CF, and 377 for bronchiectasis. Peaks selected for protein identification yielded calgranulin A, calgranulin B, calgranulin C, Clara cell secretory protein, lysosyme c, proline rich salivary peptide, cystatin s, and hemoglobin alpha. On treatment of an infective CF exacerbation, SELDI-TOF determined falls in levels of calgranulin A and calgranulin B that were mirrored by ELISA-measured falls in calprotectin (heterodimer of calgranulins A and B).Conclusions: Proteomic screening of sputum yields potential biomarkers of inflammation. The early development of a clinically relevant assay from such data is demonstrated. [ABSTRACT FROM AUTHOR]

Published
2008
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237. Excavations at Dunure Road, Ayrshire: a Bronze Age cist cemetery and standing stone.

Author

Duffy, Paul R. J., Finlay, N., MacGregor, G., McLaren, D., McKenzie, J., Miller, J., Ramsay, S., Sheridan, A., Smith, C., and Will, R.

Subjects
ARCHAEOLOGICAL excavations, BRONZE Age, CEMETERIES, MENHIRS, CREMATION
Abstract

In March 2005, excavations were undertaken by Glasgow University Archaeological Research Division (GUARD) at the Craig Tara Holiday Park, Dunure Road, Ayr in advance of proposed development. Two main archaeological sites were examined. The first, a flat cist cemetery covered by an earthen mound, comprised 23 separate burial features of varying morphology from two separate phases of burial, including cists, pits and what has been interpreted as a 'boat-shaped' setting. Nine cremations and four possible inhumations were recovered from within the burial features as well as a range of material culture including Food Vessels, flint artefacts and a bone pin. Dating of cremated bone from the cists indicated that activity at the site stretched from the late third to the early second millennium BC. The second site, a demolished or fallen standing stone, was located some 35m to the north and east of the first. Although the sequence of monument construction and demolition is clear, the reasons for the demolition of the stone are less so. However, a rare opportunity to date the stone was presented with the identification of a cremation deposit within the construction pit backfill. This indicated that the stone was constructed in the last quarter of the second millennium BC, suggesting a continuum of activity in the area late into the second millennium BC. [ABSTRACT FROM AUTHOR]

Published
2007

238. SPEIR: developing a common information environment in Scotland.

Author

Nicholson D, Dunsire G, and Macgregor G

Abstract

Purpose-To report on the work of the SPEIR project and indicate its relevance beyond the Scottish information environment. SPEIR was funded by the Scottish Library and Information Council to identify, research, and develop the elements of an internationally interoperable Scottish Common Information Environment (SCIE) for Library, Museum and Archive domain information services, and to determine the best path for future progress. A key focus was to determine the distributed information infrastructure requirements of a pilot Scottish Cultural Portal being developed in parallel with the SPEIR work, building on existing pilot initiatives such as the CAIRNS distributed catalogue and landscaper, the SCONE collections database, the SCAMP staff portal and an embryonic organisational infrastructure based on the Confederation of Scottish Mini-cooperatives (CoSMiC).Design/methodology/approach-A series of practical pilots was undertaken. These were underpinned by relevant desk and field research and conducted within an overarching holistic approach to developing the distributed environment.Practical implications-Key outcomes included the creation of a single upgraded integrated service incorporating an extended distributed catalogue, collections database, and landscaper, the creation of a pilot distributed digital library, the development of open-URL-based facilities to permit portals to incorporate 'canned searches' of the catalogue, the collections database, the SDDL, and other compatible services, an illustrative pilot Scottish terminology mapping service, and various organisational infrastructure and professional support improvements.Originality/value-The embryonic technical and organisational infrastructure reported may provide a model for other small countries (or regions within larger countries) seeking a coherent approach to the development of an interoperable information environment. [ABSTRACT FROM AUTHOR]

Published
2006
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