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1,445 results on '"Ma, Zhiyong"'

201. sj-docx-1-tam-10.1177_17588359221138380 – Supplemental material for An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870)

Author

Lu, Shun, Cheng, Ying, Zhou, Jianying, Wang, Mengzhao, Zhao, Jun, Wang, Baocheng, Chen, Gongyan, Feng, Jifeng, Ma, Zhiyong, Wu, Lin, Wang, Changli, Ma, Kewei, Zhang, Shucai, Liang, Jun, Song, Yong, Wang, Jie, Wu, Yi-Long, Li, Ang, Huang, Yizhi, and Chang, Jianhua

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tam-10.1177_17588359221138380 for An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870) by Shun Lu, Ying Cheng, Jianying Zhou, Mengzhao Wang, Jun Zhao, Baocheng Wang, Gongyan Chen, Jifeng Feng, Zhiyong Ma, Lin Wu, Changli Wang, Kewei Ma, Shucai Zhang, Jun Liang, Yong Song, Jie Wang, Yi-Long Wu, Ang Li, Yizhi Huang and Jianhua Chang in Therapeutic Advances in Medical Oncology

Published
2022
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203. Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review

Author

Wahaab, Abdul, Mustafa, Bahar E, Hameed, Muddassar, Stevenson, Nigel J., Anwar, Muhammad Naveed, Liu, Ke, Wei, Jianchao, Qiu, Yafeng, and Ma, Zhiyong

Subjects
viruses, virus diseases, biochemical phenomena, metabolism, and nutrition, complex mixtures
Abstract

Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored. The flavivirus NS2B-NS3 proteases are responsible for the cleavage of the flavivirus polyprotein, which is necessary for productive viral infection and for causing clinical infections; therefore, they are a promising drug target for devising novel drugs against different flaviviruses. This review highlights the structural details of the NS2B-NS3 proteases of different flaviviruses, and also describes potential antiviral drugs that can interfere with the viral protease activity, as determined by various studies. Moreover, optimized in vitro reaction conditions for studying the NS2B-NS3 proteases of different flaviviruses may vary and have been incorporated in this review. The increasing availability of the in silico and crystallographic/structural details of flavivirus NS2B-NS3 proteases in free and drug-bound states can pave the path for the development of promising antiflavivirus drugs to be used in clinics. However, there is a paucity of information available on using animal cells and models for studying flavivirus NS2B-NS3 proteases, as well as on the testing of the antiviral drug efficacy against NS2B-NS3 proteases. Therefore, on the basis of recent studies, an effort has also been made to propose potential cellular and animal models for the study of flavivirus NS2B-NS3 proteases for the purposes of exploring flavivirus pathogenesis and for testing the efficacy of possible drugs targets, in vitro and in vivo. Published version

Published
2021

208. Molecular Epidemic Characteristics and Genetic Evolution of Porcine Circovirus Type 2 (PCV2) in Swine Herds of Shanghai, China

Author

Kang, Le, primary, Wahaab, Abdul, additional, Shi, Kun, additional, Mustafa, Bahar E, additional, Zhang, Yan, additional, Zhang, Junjie, additional, Li, Zongjie, additional, Qiu, Yafeng, additional, Li, Beibei, additional, Liu, Ke, additional, Shao, Donghua, additional, Ma, Zhiyong, additional, Zhong, Dengke, additional, and Wei, Jianchao, additional

Published
2022
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210. An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870)

Author

Lu, Shun, primary, Cheng, Ying, additional, Zhou, Jianying, additional, Wang, Mengzhao, additional, Zhao, Jun, additional, Wang, Baocheng, additional, Chen, Gongyan, additional, Feng, Jifeng, additional, Ma, Zhiyong, additional, Wu, Lin, additional, Wang, Changli, additional, Ma, Kewei, additional, Zhang, Shucai, additional, Liang, Jun, additional, Song, Yong, additional, Wang, Jie, additional, Wu, Yi-Long, additional, Li, Ang, additional, Huang, Yizhi, additional, and Chang, Jianhua, additional

Published
2022
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215. Various mobile genetic elements carrying optrA in Enterococcus faecium and Enterococcus faecalis isolates from swine within the same farm.

Author

Xuan, Huiyong, Xia, Lining, Schwarz, Stefan, Jia, Haiyan, Yao, Xiaohui, Wang, Shufeng, Li, Ruichao, Wei, Jianchao, Li, Zongjie, Shao, Donghua, Liu, Ke, Qiu, Yafeng, Ma, Zhiyong, and Li, Beibei

Subjects
ENTEROCOCCUS, MOBILE genetic elements, ENTEROCOCCUS faecium, ENTEROCOCCUS faecalis, FINISHES & finishing, SWINE farms, MICROBIAL sensitivity tests, POULTRY farms
Abstract

Objectives In this study, the distribution of the oxazolidinone/phenicol resistance gene optrA and the mobile genetic elements involved in its dissemination were analysed among enterococcal isolates from a farrow-to-finish swine farm. Methods Enterococcus faecium and Enterococcus faecalis isolates were obtained from all pig production stages in the farm. The optrA -carrying E. faecium and E. faecalis isolates were subjected to PFGE and antimicrobial susceptibility testing. Complete sequences of the genetically unrelated optrA -carrying E. faecium and E. faecalis isolates were determined using Illumina HiSeq and MinION platforms. Results The optrA gene was present in 12.2% (23/188) of the E. faecium and E. faecalis isolates, most of which originated from nursery and finishing stages. The 23 optrA -positive Enterococcus isolates represented 15 PFGE types. WGS of representative isolates of the 15 PFGE types showed that optrA was carried by diverse genetic elements either located in the chromosomal DNA or on plasmids. A novel optrA -bearing genetic element was identified on two distinct multi-resistance plasmids from E. faecium. Two new hybrid plasmids carrying several resistance genes were found in two E. faecalis isolates. pC25-1-like plasmids and chromosomally integrated Tn 6674 and Tn 6823 -like transposons were prevalent in the remaining Enterococcus isolates. Conclusions The gene optrA was found in genetically unrelated E. faecium and E. faecalis isolates from the same farm. Analysis of the genetic contexts of optrA suggested that horizontal transfer including different plasmids and transposons played a key role in the dissemination of optrA in this farm. [ABSTRACT FROM AUTHOR]

Published
2023
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216. A Class of Organic Units Featuring Matrix‐Controlled Color‐Tunable Ultralong Organic Room Temperature Phosphorescence.

Author

Zhang, Xue, Qian, Chen, Ma, Zhimin, Fu, Xiaohua, Li, Zewei, Jin, Huiwen, Chen, Mingxing, Jiang, Hong, and Ma, Zhiyong

Subjects
DERIVATIVES (Mathematics), RADICAL cations, INTERMOLECULAR interactions, PHOSPHORESCENCE, METHACRYLATES, TEMPERATURE
Abstract

A novel class of organic units (N‐1 and N‐2) and their derivatives (PNNA‐1 and PNNA‐2) with excellent property of ultralong organic room temperature phosphorescence (UORTP) is reported. In this work, N‐1, N‐2, and their derivatives function as the guests, while organic powders (PNCz, BBP, DBT) and polymethyl methacrylate (PMMA) serve as the host matrixes. Amazingly, the color of phosphorescence can be tuned in different states or by varying the host matrixes. At 77 K, all molecules show green afterglow in the monomer state but yellow afterglow in the aggregated state because strong intermolecular interactions exist in the self‐aggregate and induce a redshift of the afterglow. In particular, PNNA‐1 and PNNA‐2 demonstrate distinctive photoactivated green UORTP in the PMMA film owing to the generation of their cation radicals. Whereas the PNNA‐1@PNCz and PNNA‐2@PNCz doping powders give out yellow UORTP, showing matrix‐controlled color‐tunable UORTP. In PNCz, the cation radicals of PNNA‐1 and PNNA‐2 can stay stably and form strong intermolecular interactions with PNCz, leading to a redshift of ultralong phosphorescence. [ABSTRACT FROM AUTHOR]

Published
2023
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225. A Novel Recombinant Virus-Like Particles Displaying B and T Cell Epitopes of Japanese Encephalitis Virus Offers Protective Immunity in Mice and Guinea Pigs

Author

Anwar, Muhammad Naveed, primary, Jiang, Chunying, additional, Di, Di, additional, Zhang, Junjie, additional, Guo, Shuang, additional, Wang, Xin, additional, Hameed, Muddassar, additional, Wahaab, Abdul, additional, Shao, Donghua, additional, Li, Zongjie, additional, Liu, Ke, additional, Li, Beibei, additional, Qiu, Yafeng, additional, Ma, Zhiyong, additional, and Wei, Jianchao, additional

Published
2021
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226. Codoped 2D All-Inorganic Halide Perovskite Cs3Cd2Cl7:Sb3+:Mn2+with Ultralong Afterglow

Author

Dai, Guangkuo, Ma, Zhimin, Qiu, Yixin, and Ma, Zhiyong

Abstract

Herein, we synthesized a Sb3+/Mn2+-codoped 2D all-inorganic halide perovskite Cs3Cd2Cl7:Sb3+:Mn2+with ultralong afterglow emission at 579 nm. High-quality sheet-like single crystals are obtained by solvent evaporation and have an average crystal size of about 100 μm. We also synthesized Sb3+and Mn2+single-doped crystals by the same method so as to better understand the photophysical mechanism of the long afterglow phenomenon of the double-doped crystals. Through the codoping of Sb3+and Mn2+, energy transfer occurs between the self-trapped exciton (STE) energy level of Sb3+and the 4T1–6A1transition of Mn2+, resulting in a visible afterglow of over 10 s. It is revealed that the changes in afterglow properties originate from the introduction of doping elements. And then, photoluminescence (PL) decay spectra and temperature-dependent PL spectra were tested to further illustrate the mechanism. Finally, it is proved that the codoped crystal has excellent stability and can meet various needs. All of the results demonstrate the unique afterglow properties and provide new examples for the development of all-inorganic halide afterglow materials.

Published
2023
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228. Recent progress in determination of ochratoxin a in foods by chromatographic and mass spectrometry methods.

Author

Li, Xianjiang, Ma, Wen, Ma, Zhiyong, Zhang, Qinghe, and Li, Hongmei

Subjects
MASS spectrometry, DRIED fruit, FRUIT drying, FOOD safety, COFFEE, COCOA, BEER
Abstract

Ochratoxin A is a highly toxic mycotoxin and has posed great threat to human health. Due to its serious toxicity and wide contamination, great efforts have been made to develop reliable determination methods. In this review, analytical methods are comprehensively summarized in terms of sample preparation strategy and instrumental analysis. Detailed method is described according to the food commodities in the order of cereal, wine, coffee, beer, cocoa, dried fruit and spice. This review mainly focuses on the recent advances, especially reported in the last decade. At last, challenges and perspectives are also discussed to achieve better advancement and promote practical application in this field. [ABSTRACT FROM AUTHOR]

Published
2022
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231. Corrigendum to “A phase 2 study of tislelizumab in combination with platinum-based chemotherapy as first-line treatment for advanced lung cancer in Chinese patients” [Lung Cancer 147 (2020) 259–268]

Author

Wang, Zhijie, primary, Zhao, Jun, additional, Ma, Zhiyong, additional, Cui, Jiuwei, additional, Shu, Yongqian, additional, Liu, Zhe, additional, Cheng, Ying, additional, Leaw, Shiang J., additional, Wu, Yanjie, additional, Ma, Yan, additional, Tan, Wei, additional, Ma, Xiaopeng, additional, Zhang, Yun, additional, and Wang, Jie, additional

Published
2021
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233. Abstract CT039: Results from RATIONALE 303: A global phase 3 study of tislelizumab (TIS) vs docetaxel (TAX) as second- or third-line therapy for patients with locally advanced or metastatic NSCLC

Author

Zhou, Caicun, primary, Huang, Dingzhi, additional, Yu, Xinmin, additional, Liu, Yunpeng, additional, Fan, Yun, additional, Shu, Yongqian, additional, Ma, Zhiyong, additional, Wang, Ziping, additional, Cheng, Ying, additional, Wang, Jie, additional, Hu, Sheng, additional, Liu, Zhihua, additional, Dvorkin, Mikhail, additional, Poddubskaya, Elena, additional, Disel, Umut, additional, Akopov, Andrey, additional, Ma, Yiyuan, additional, Wang, Yan, additional, Pan, Zhenyu, additional, Yu, Cunjing, additional, and Rivalland, Gareth, additional

Published
2021
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240. Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR

Author

Yan, An, Ding, GuoHui, Zhou, ZhenFeng, Dong, Hui, Zhang, YaKun, Zhu, Lei, He, YunGang, Zhang, GuoQing, Li, YiXue, Sun, Bing, Huang, Zhong, Lan, Ke, Jin, Li, Wang, HongYan, Wang, XiaoNing, Yang, Zhong, Zhong, Yang, Dai, JianXin, Guo, YaJun, Wang, Hao, Che, XiaoYan, Wu, Fan, Yuan, ZhenGan, Zhang, Xi, Cao, ZhiWei, Zhou, XiaoNong, Zhou, JiaHai, Ma, ZhiYong, Tong, GuangZhi, Zhao, GuoPing, Jin, WeiRong, and Xiong, Hui

Published
2009
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244. Progression pattern and post-progression treatment of furmonertinib (AST2818) in EGFR T790M mutation positive NSCLC patients: A post-hoc analysis from a multicenter, single-arm study.

Author

Hu, Xingsheng, primary, Zhang, Shucai, additional, Lv, Dongqing, additional, Wu, Lin, additional, Yu, Qitao, additional, Zhang, Yiping, additional, Liu, Li, additional, Wang, Xiang, additional, Cheng, Ying, additional, Ma, Zhiyong, additional, Niu, Hongrui, additional, Wang, Dong, additional, Feng, Jifeng, additional, Huang, Cheng, additional, Liu, Chunling, additional, Zhao, Hui, additional, Li, Jingzhang, additional, Zhang, Xiaodong, additional, Jiang, Yong, additional, and Shi, Yuankai, additional

Published
2021
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246. Comparison of population characteristics, treatment modes, and clinical outcomes of patients with advanced non-small cell lung cancer in clinical trials and in the real world received PD-1/PD-L1 inhibitor.

Author

Ma, Zhiyong, primary, Wang, Huijuan, additional, Wei, Chunhua, additional, guo Wei, Zhang, additional, Yan, Xiangtao, additional, Zhang, Mina, additional, Zhang, Xiaojuan, additional, Niu, Yuanyuan, additional, and Yang, Jinpo, additional

Published
2021
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