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1,317 results on '"Ma, Lena Q."'

210. Metal tolerance of arsenic-resistant bacteria and their ability to promote plant growth of Pteris vittata in Pb-contaminated soil

Author

Manzoor, Maria, primary, Abid, Rafia, additional, Rathinasabapathi, Bala, additional, De Oliveira, Letuzia M., additional, da Silva, Evandro, additional, Deng, Fenglin, additional, Rensing, Christopher, additional, Arshad, Muhammad, additional, Gul, Iram, additional, Xiang, Ping, additional, and Ma, Lena Q., additional

Published
2019
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227. Aquaporins mediated arsenite transport in plants: Molecular mechanisms and applications in crop improvement.

Author

Deng, Fenglin, Liu, Xue, Chen, Yanshan, Rathinasabapathi, Bala, Rensing, Christopher, Chen, Jian, Bi, Jue, Xiang, Ping, and Ma, Lena Q.

Subjects
AQUAPORINS, CROP improvement, CHARACTERISTIC functions, MICRORNA, CELL membranes
Abstract

Arsenic (As) is a carcinogen and it is ubiquitous in the environment. Its accumulation in plants can enter the food chain, thereby causing adverse impacts on human health. Based on studies using Xenopus oocytes, engineered microbes, and model plants, aquaporins play key roles in arsenite (AsIII) passage across the cell membrane. Herein, we summarized the roles of aquaporins in AsIII uptake, transport, and accumulation. The coupling action between polar-localized aquaporins and positive transporters probably explains the efficient As transport mediated by bi-directional channels. The expression of aquaporins is regulated at both transcriptional and post-transcriptional levels via microRNAs. However, in response to As, the proteins can be modified through phosphorylation and be degraded via the ubiquitin 26S proteasome system. Further, a proposed model comprising reactive oxygen species, Ca, Ca-dependent kinases, and transcriptional factors is constructed to reveal the signaling pathways and aquaporins' responses to As in model plants. We also provided strategies to identify and investigate putative aquaporins in plants. Identification and modification of aquaporins' residues critical for their substrate selectivity, and optimization of their expression pattern by employing appropriate promoters can be employed to reduce As accumulation in crops. Based on the characteristics of their functions and expression patterns, it is promising to employ aquaporins for genetic-engineering of crops to reduce As content and increase food safety. [ABSTRACT FROM AUTHOR]

Published
2020
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228. Organoarsenical compounds: Occurrence, toxicology and biotransformation.

Author

Chen, Jian, Garbinski, Luis D., Rosen, Barry, Zhang, Jun, Xiang, Ping, and Ma, Lena Q.

Subjects
TOXICOLOGY, NEUROLOGICAL disorders, ORGANIC compounds, KNOWLEDGE gap theory, SKIN cancer
Abstract

Arsenic is a ubiquitous metalloid found in the environment. Its chronic exposure is of global health concern as it causes lung, skin and bladder cancers, as well as non-cancer illness such as skin lesions, and cardiovascular and neurological diseases. While the environmental occurrence, fate, and toxicity of inorganic As has been well documented, limited research is available on organic As compounds. Organic As compounds often result from As metabolism in marine organisms, but they also enter the biosphere through anthropogenic activities including feed additives for livestock. Here, the state of knowledge on organic As is reviewed, encompassing their occurrence, toxicology and biotransformation including biosynthesis, methylation, and degradation. Knowledge gaps and possible research directions are identified, including metabolic pathways of synthesis and degradation, the impacts of metabolic transformations on toxicity and development of new analytical methods. [ABSTRACT FROM AUTHOR]

Published
2020
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