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503 results on '"MIZUTANI, Hiroshi"'

201. Senescent dermal fibroblasts enhance stem cell migration through CCL2/ CCR2 axis.

Author

Ohgo, Shiro, Hasegawa, Seiji, Hasebe, Yuichi, Mizutani, Hiroshi, Nakata, Satoru, and Akamatsu, Hirohiko

Subjects
AGING, STEM cell research, CELL migration, CHEMOKINE receptors, FIBROBLASTS
Abstract

During aging, increases in the number of senescent cells are seen in various tissues. On the other hand, stem cells play crucial roles in tissue repair and homeostasis. Therefore, it is likely that stem cells give rise to new cells that replace senescent cells. However, how stem cells contribute to homeostasis in the dermis has not been elucidated. Here, we investigated the effects of factors secreted from senescent fibroblasts on stem cells. We found that senescent human dermal fibroblast ( HDF) conditioned medium ( CM) significantly enhanced stem cell migration compared with young HDF CM. The senescent HDF CM strongly secreted chemokine ligand 2 ( CCL2). Furthermore, CCL2 was found to enhance stem cell migration, and the inhibition of CCR2, a receptor for CCL2, reduced stem cell migration. These results suggest that senescent fibroblasts recruit stem cells by secreting various factors and that the CCL2/ CCR2 axis is one of the mechanisms underlying this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2015
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204. Endometriosis: Evaluation of endometriosis in uterosacral ligaments by transrectal ultrasonography.

Author

Ohba, Takashi, Mizutani, Hiroshi, Maeda, Takahiro, Matsuura, Kohei, and Okamura, Hitoshi

Abstract

Uterosacral ligaments are one of the common targets of pelvic endometriosis, which is usually clinically rather than surgically diagnosed. This study was performed to determine if uterosacral ligaments infiltrated by endometriosis could be detected by transrectal ultrasonography. Uterosacral ligaments in non-endometriosis subjects (n±64) were observed as low echoic homogeneous arcs in both sides of the uterine cervix. Patients who had endometriosis (n±29) on the ligaments showed thick and irregularly-shaped uterosacral ligaments by the transrectal ultrasound examination. The results also suggested that the thickness of uterosacral ligaments was associated with the clinical symptoms. Transrectal ultrasonography may provide quantitative information to manage patients with inilitrat ing endometriosis. [ABSTRACT FROM PUBLISHER]

Published
1996
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206. Forced eruption by SmCo5 magnetic technique

Author

Mizutani Hiroshi, Ishihata Nobuo, and Ai Minoru

Subjects
Clinical Practice, stomatognathic diseases, Sound tooth, Materials science, stomatognathic system, Orthodontic wire, business.industry, Perforation (oil well), Dentistry, General Medicine, business, Dental alveolus
Abstract

It is always submitted to indication of tooth extraction when advanced caries, traumatic destruction, or lateral root perforation reaches to alveolar bone crest. However, if we can forcedly elongate such conditioned tooth, then sound tooth structure will appear out of gingiva and we can make a restoration very easily.The orthodontic wire technique which elongates tooth is not often used for the adults in daily clinical practice, since it is difficult to adjust orthodontic forces, in addition it produces anterior aesthetic deformities and uncomfortableness.Here we introduce SmCo5 magnetic elongation technique, which makes up for the above mentioned demerits, and its clinical cases.

Published
1986
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211. Carbon isotope composition of CH4 from rice paddies in Japan

Author

Uzaki, Minoru, Mizutani, Hiroshi, and Wada, Eitaro

Abstract

Carbon isotope ratios (d13C) for bubble CH4 in a submerged paddy soil were studied in Yokohama, Japan, throughout a growing period, and its variation was found. Bubble CH4 collected from other 33 paddy fields in Japan was also measured for its d13C and the results agreed with Yokohama. Furthermore, the variation occurred irrespective of the amount and the type of supplied organic substances to the fields (whole rice straw, rice stubble, or compost). The d13C value (average value of -55.9 ± 4.24‰) from these paddy fields was higher than those of the CH4 emitted from African and North American paddies. The higher value was little affected by their difference in the supplied organic substances. CH4 oxidation likely occurs for bubble CH4 in the shallow paddy fields. A rough estimate of the total CH4 production, using isotope mass balance, showed that 17 to 22% of organic carbon supplied to Japanese paddies transforms to CH4.

Published
1991
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212. Preparation and Conformational Properties of Several 1,8-Diarylnaphthalenes

Author

Ibuki, Eiichi, Ozasa, Shigeru, Fujioka, Yasuhiro, and Mizutani, Hiroshi

Abstract

Six new 1,8-diarylnaphthalenes, each having closely held parallel aromatic rings, were synthesized by a Kharash-type Grignard cross-coupling of arylmagnesium iodide and 1,8-diiodonaphthalene in the presence of N,N′-bis(1-methyl-3-oxobutylidene)ethylenediaminatonickel(II) as a catalyst. Among them, 1,8-di(1-naphthyl) naphthalene was obtained as cisand transrotamers, caused by the restricted rotation at the 1,8-position. Interconversion between the rotamers on heating above their melting points was confirmed by differential scanning calorimetry. The proton magnetic resonance spectral studies of the 1,8-diarylnaphthalenes indicated the presence of a face-to-face arrangement of aromatic rings in the peri-position. Two new 8,8′-diaryl-1,1′-binaphthyls, each having two sets of closely held parallel aromatic rings, were isolated as minor coupling products. Trans-transconformations were proposed for them on the basis of their thermal behavior. Several nickel(II) complexes were found to be effective catalysts for preparative Grignard cross-coupling reaction involving closely crowded geometry.

Published
1982
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213. Effect of high atmospheric CO2 concentration on δ13 of algae

Author

Mizutani, Hiroshi and Wada, Eitaro

Abstract

Precambrian reduced carbon is more depleted in13C than what would be expected from the carbon isotopic composition of modern marine algae and algal mats. Since the photosynthetic carbon fixation by algae is the most likely source of the reduced carbon, the depletion has been considered an anomaly.

Published
1982
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214. THE PHOTOCHEMICAL REACTION OF HYDROGEN CYANIDE IN GAS PHASE AT 184.9 nm

Author

Mizutani, Hiroshi, Mikuni, Hitoshi, and Takahasi, Makoto

Abstract

The photochemistry of hydrogen cyanide at 184.9 nm was studied. Major reaction products are cyanogen and hydrogen, and minors are methane, ammonia, ethane, hydrazine and methylamine. The addition of hydrogen atoms to hydrogen cyanide is considered for the formation of these products. A reddish brown polymeric substance was also obtained and its IR spectrum is presented.

Published
1972
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238. Laser Surgery of Basal, Orbital and Ventricular Meningiomas which are Difficult to Extirpate by Conventional Methods

Author

TAKIZAWA, Toshiaki, primary, YAMAZAKI, Takashi, additional, MIURA, Noriko, additional, MATSUMOTO, Masahisa, additional, TANAKA, Yasuaki, additional, TAKEUCHI, Kazuo, additional, NAKATA, Yoshitaka, additional, TOGASHI, Osamu, additional, NAGAI, Masakatsu, additional, ARIGA, Toru, additional, NISHIMURA, Toshihiko, additional, MIZUTANI, Hiroshi, additional, and SANO, Keiji, additional

Published
1980
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248. A Clinical Survey of Partial Dentures (III)

Author

Shibuya, Takashi, primary, Matsumoto, Makoto, additional, Kawasaki, Ryuji, additional, Goto, Tadamasa, additional, Ogusa, Hiroshi, additional, Ishiwata, Yoshihiro, additional, Mizutani, Hiroshi, additional, Endo, Yasuo, additional, Takahashi, Kyoko, additional, Igarashi, Yoshimasa, additional, Ishihata, Nobuo, additional, Ogino, Akira, additional, Manabe, Akira, additional, Shinohara, Joji, additional, and Ono, Keiichi, additional

Published
1976
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