42,711 results on '"Luis, E"'
Search Results
202. Application of Formal Concept Analysis to Characterize Driving Behaviors and Socio-Cultural Factors Related to Driving.
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Diogo Miranda, Luis E. Zárate, and Mark A. J. Song
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- 2024
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203. Triadic Rules for Analysis of Productive and Well-Being Social in Activity-Based Working Environments.
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Thiago H. C. Oliveira, Mark A. J. Song, and Luis E. Zárate
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- 2024
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204. Longitudinal Data Analysis Based on Triadic Rules to Describe of the Psychological Reactions During COVID 19 Pandemic.
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Lincoln A. N. Coutinho, Mark A. J. Song, and Luis E. Zárate
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- 2024
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205. Improving Autonomous Separation Assurance through Distributed Reinforcement Learning with Attention Networks.
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Marc W. Brittain, Luis E. Alvarez, and Kara Breeden
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- 2024
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206. Mangroves of the Brazilian Coastal Amazon: Preservation and Threats
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Aragón, Luis E., Clüsener-Godt, Miguel, Clüsener-Godt, Miguel, editor, Matsuda, Hiroyuki, editor, Böer, Benno, editor, and Loughland, Ronald A., editor
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- 2024
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207. Biobased Encapsulated Rejuvenators to Promote Extrinsic Self-Healing in Bituminous Materials
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Concha, Jose L., Arteaga-Pérez, Luis E., Norambuena-Contreras, Jose, Vasconcelos, Kamilla, editor, Jiménez del Barco Carrión, Ana, editor, Chailleux, Emmanuel, editor, and Lo Presti, Davide, editor
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- 2024
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208. Rejuvenator Based on Pyrolysis of Waste Tyres to Improve Aged Asphalt Rheological Properties
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Chávez-Delgado, Manuel, Concha, José L., Arteaga-Pérez, Luis E., Norambuena-Contreras, Jose, Vasconcelos, Kamilla, editor, Jiménez del Barco Carrión, Ana, editor, Chailleux, Emmanuel, editor, and Lo Presti, Davide, editor
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- 2024
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209. Pediatric Spine Trauma
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Cabrera Cousiño, Juan P., Guiroy, Alfredo, Carelli, Luis E., Slullitel, Pablo, editor, Rossi, Luciano, editor, and Camino-Willhuber, Gastón, editor
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- 2024
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210. Design and Implementation of an Open Daylight Event Management System Through the Integration of a Business Process Management
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Benavides Castillo, Luis E., Castro González, Christian X., Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Botto-Tobar, Miguel, editor, Zambrano Vizuete, Marcelo, editor, Montes León, Sergio, editor, Torres-Carrión, Pablo, editor, and Durakovic, Benjamin, editor
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- 2024
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211. Fiber Optic Application in Metallurgical Processes’ External and Internal Temperature Monitoring of Metallurgical Furnaces with Distributed Temperature Sensor (DTS)
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Gomez, Luis E. Gonzalez, Viraca, Luis Chambi, Choque, Stefany Michelle Huanca, Acho, Carlos, and The Minerals, Metals & Materials Society
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- 2024
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212. One-Time Passwords: A Literary Review of Different Protocols and Their Applications
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Almeida, Luis E., Fernández, Brayan A., Zambrano, Daliana, Almachi, Anthony I., Pillajo, Hilton B., Yoo, Sang Guun, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Guarda, Teresa, editor, Portela, Filipe, editor, and Diaz-Nafria, Jose Maria, editor
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- 2024
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213. Atención psicológica en unidad de cuidado crítico durante la pandemia por Covid 19
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Villegas Gallego, Marcela, Oeding Angulo, Guillermo, Lastra Terán, Katya P., Severino, Luis E., Arango Castaño, Jorge, Mebarak, Moisés, and Abello-Llanos, Raimundo
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- 2024
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214. A short trajectory is all you need: A transformer-based model for long-time dissipative quantum dynamics.
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Herrera Rodríguez, Luis E. and Kananenka, Alexei A.
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ARTIFICIAL neural networks , *QUANTUM theory , *TRANSFORMER models , *POPULATION dynamics , *SYSTEM dynamics , *RECURRENT neural networks - Abstract
In this Communication, we demonstrate that a deep artificial neural network based on a transformer architecture with self-attention layers can predict the long-time population dynamics of a quantum system coupled to a dissipative environment provided that the short-time population dynamics of the system is known. The transformer neural network model developed in this work predicts the long-time dynamics of spin-boson model efficiently and very accurately across different regimes, from weak system–bath coupling to strong coupling non-Markovian regimes. Our model is more accurate than classical forecasting models, such as recurrent neural networks, and is comparable to the state-of-the-art models for simulating the dynamics of quantum dissipative systems based on kernel ridge regression. [ABSTRACT FROM AUTHOR]
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- 2024
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215. Designed Y3+ Surface Segregation Increases Stability of Nanocrystalline Zinc Aluminate
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Martin, Luis E Sotelo, O’Shea, Nicole M, Mason, Jeremy K, and Castro, Ricardo HR
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Bioengineering ,Nanotechnology ,Affordable and Clean Energy ,Chemical Sciences ,Engineering ,Technology ,Physical Chemistry - Abstract
The thermal stability of zinc aluminate nanoparticles is critical for their use as catalyst supports. In this study, we experimentally show that doping with 0.5 mol % Y2O3 improves the stability of zinc aluminate nanoparticles. The dopant spontaneously segregates to the nanoparticle surfaces in a phenomenon correlated with excess energy reduction and the hindering of coarsening. Y3+ was selected based on atomistic simulations on a 4 nm zinc aluminate nanoparticle singularly doped with elements of different ionic radii: Sc3+, In3+, Y3+, and Nd3+. The segregation energies were generally proportional to ionic radii, with Y3+ showing the highest potential for surface segregation. Direct measurements of surface thermodynamics confirmed the decreasing trend in surface energy from 0.99 for undoped to 0.85 J/m2 for Y-doped nanoparticles. Diffusion coefficients calculated from coarsening curves for undoped and doped compositions at 850 °C were 4.8 × 10-12 cm2/s and 2.5 × 10-12 cm2/s, respectively, indicating the coarsening inhibition induced by Y3+ results from a combination of a reduced driving force (surface energy) and decreased atomic mobility.
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- 2023
216. Engineering Cyborg Bacteria Through Intracellular Hydrogelation
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Contreras‐Llano, Luis E, Liu, Yu‐Han, Henson, Tanner, Meyer, Conary C, Baghdasaryan, Ofelya, Khan, Shahid, Lin, Chi‐Long, Wang, Aijun, Hu, Che‐Ming J, and Tan, Cheemeng
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Biochemistry and Cell Biology ,Biological Sciences ,Biotechnology ,Bioengineering ,1.3 Chemical and physical sciences ,Underpinning research ,Generic health relevance ,Humans ,Synthetic Biology ,Bacteria ,Polymers ,cellular chassis ,hybrid material ,hydrogel ,nonreplicating bacteria ,nonculturable cells ,synthetic biology - Abstract
Natural and artificial cells are two common chassis in synthetic biology. Natural cells can perform complex tasks through synthetic genetic constructs, but their autonomous replication often causes safety concerns for biomedical applications. In contrast, artificial cells based on nonreplicating materials, albeit possessing reduced biochemical complexity, provide more defined and controllable functions. Here, for the first time, the authors create hybrid material-cell entities termed Cyborg Cells. To create Cyborg Cells, a synthetic polymer network is assembled inside each bacterium, rendering them incapable of dividing. Cyborg Cells preserve essential functions, including cellular metabolism, motility, protein synthesis, and compatibility with genetic circuits. Cyborg Cells also acquire new abilities to resist stressors that otherwise kill natural cells. Finally, the authors demonstrate the therapeutic potential by showing invasion into cancer cells. This work establishes a new paradigm in cellular bioengineering by exploiting a combination of intracellular man-made polymers and their interaction with the protein networks of living cells.
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- 2023
217. Leaf clustering using circular densities
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Nieto-Barajas, Luis E.
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Statistics - Applications - Abstract
In the biology field of botany, leaf shape recognition is an important task. One way of characterising the leaf shape is through the centroid contour distances (CCD). Each CCD path might have different resolution, so normalisation is done by considering that they are circular densities. Densities are rotated by subtracting the mean preferred direction. Distance measures between densities are used to produce a hierarchical clustering method to classify the leaves. We illustrate our approach with a real dataset.
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- 2022
218. Unconventional charge-to-spin conversions in graphene/MoTe2 van der Waals heterostructures
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Ontoso, Nerea, Safeer, C. K., Herling, Franz, Ingla-Aynés, Josep, Yang, Haozhe, Chi, Zhendong, Robredo, Iñigo, Vergniory, Maia G., de Juan, Fernando, Calvo, M. Reyes, Hueso, Luis E., and Casanova, Fèlix
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Spin-charge interconversion (SCI) is a central phenomenon to the development of spintronic devices from materials with strong spin-orbit coupling (SOC). In the case of materials with high crystal symmetry, the only allowed SCI processes are those where the spin current, charge current and spin polarization directions are orthogonal to each other. Consequently, standard SCI experiments are designed to maximize the signals arising from the SCI processes with conventional mutually orthogonal geometry. However, in low-symmetry materials, certain non-orthogonal SCI processes are also allowed. Since the standard SCI experiment is limited to charge current flowing only in one direction in the SOC material, certain allowed SCI configurations remain unexplored. In this work, we performed a thorough SCI study in a graphene-based lateral spin valve combined with low-symmetry MoTe$_2$. Due to a very low contact resistance between the two materials, we could detect SCI signals using both a standard configuration, where the charge current is applied along the MoTe$_2$, and a recently introduced (3D-current) configuration, where the charge current flow can be controlled in three directions within the heterostructure. As a result, we observed three different SCI components, one orthogonal and two non-orthogonal, giving new insight into the SCI processes in low-symmetry materials. The large SCI signals obtained at room temperature, along with the versatility of the 3D-current configuration, provide feasibility and flexibility to the design of the next generation of spin-based devices., Comment: 11 pages, 4 figures
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- 2022
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219. Emergence of large spin-charge interconversion at an oxidized Cu/W interface
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Groen, Inge, Pham, Van Tuong, Ilić, Stefan, Choi, Won Young, Chuvilin, Andrey, Sagasta, Edurne, Vaz, Diogo C., Arango, Isabel C., Ontoso, Nerea, Bergeret, F. Sebastian, Hueso, Luis E., Tokatly, Ilya V., and Casanova, Fèlix
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Spin-orbitronic devices can integrate memory and logic by exploiting spin-charge interconversion (SCI), which is optimized by design and materials selection. In these devices, such as the magnetoelectric spin-orbit (MESO) logic, interfaces are crucial elements as they can prohibit or promote spin flow in a device as well as possess spin-orbit coupling resulting in interfacial SCI. Here, we study the origin of SCI in a Py/Cu/W lateral spin valve and quantify its efficiency. An exhaustive characterization of the interface between Cu and W electrodes uncovers the presence of an oxidized layer (WO$_x$). We determine that the SCI occurs at the Cu/WO$_x$ interface with a temperature-independent interfacial spin-loss conductance of $G_{||} \approx$ 20 $\times$ 10$^{13} \Omega^{-1}m^{-2}$ and an interfacial spin-charge conductivity $\sigma_{SC}=-$1610 $\Omega^{-1}cm^{-1}$ at 10 K ($-$830 $\Omega^{-1}cm^{-1}$ at 300 K). This corresponds to an efficiency given by the inverse Edelstein length $\lambda_{IEE}=-$0.76 nm at 10 K ($-$0.4 nm at 300 K), which is remarkably larger than in metal/metal and metal/oxide interfaces and bulk heavy metals. The large SCI efficiency at such an oxidized interface is a promising candidate for the magnetic readout in MESO logic devices., Comment: 11 pages, 3 figures, and Supplemental Material
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- 2022
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220. Maximal disjoint Schubert cycles in rational homogeneous varieties
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Muñoz, Roberto, Occhetta, Gianluca, and Conde, Luis E. Solá
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Mathematics - Algebraic Geometry ,14M15 - Abstract
In this paper we study properties of the Chow ring of rational homogeneous varieties of classical type, more concretely, effective zero divisors of low codimension, and a related invariant called effective good divisibility. This information is then used to study the question of (non)existence of nonconstant maps among these varieties, generalizing previous results for projective spaces and Grassmannians., Comment: 21 pages
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- 2022
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221. All-electrical spin-to-charge conversion in sputtered Bi$_x$Se$_{1-x}$
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Choi, Won Young, Arango, Isabel C., Pham, Van Tuong, Vaz, Diogo C., Yang, Haozhe, Groen, Inge, Lin, Chia-Ching, Kabir, Emily S., Oguz, Kaan, Debashis, Punyashloka, Plombon, John J., Li, Hai, Nikonov, Dmitri E., Chuvilin, Andrey, Hueso, Luis E., Young, Ian A., and Casanova, Fèlix
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
One of the major obstacles to realizing spintronic devices such as MESO logic devices is the small signal magnitude used for magnetization readout, making it important to find materials with high spin-to-charge conversion efficiency. Although intermixing at the junction of two materials is a widely occurring phenomenon, its influence on material characterization and the estimation of spin-to-charge conversion efficiencies is easily neglected or underestimated. Here, we demonstrate all electrical spin-to-charge conversion in Bi$_x$Se$_{1-x}$ nanodevices and show how the conversion efficiency can be overestimated by tens of times depending on the adjacent metal used as a contact. We attribute this to the intermixing-induced compositional change and the properties of a polycrystal that lead to drastic changes in resistivity and spin Hall angle. Strategies to improve the spin-to-charge conversion signal in similar structures for functional devices are discussed., Comment: Main text (18 pages, 3 figures, 2 tables) and supporting information (18 pages)
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- 2022
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222. Supersolid-like square- and triangular-lattice crystallization of dipolar droplets in a box trap
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Young-S., Luis E. and Adhikari, S. K.
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Condensed Matter - Quantum Gases - Abstract
Using a beyond-mean-field model including a Lee-Huang-Yang-type interaction, we demonstrate a supersolid-like spatially-periodic square- and triangular-lattice crystallization of droplets in a polarized dipolar condensate confined by an appropriate three-dimensional (3D) box trap. In this paper we consider a rectangular box (cuboid) trap, a square box (cuboid with two equal sides) trap, a cylindrical box trap and a hexagonal box (hexagonal prism) trap. The droplet lattice is always formed in the $x$-$y$ plane perpendicular to the polarization $z$ direction of dipolar atoms. In contrast to a harmonic trap, the box traps allow the formation of a large clean supersolid-like spatially-periodic crystallization in free space without any distortion. Moreover, a droplet lattice can be formed in a 3D box trap with a significantly reduced number of atoms than in a harmonic trap, which could facilitate the experimental observation of droplet lattice in a box trap. With present know-how such a supersolid-like crystallization of dipolar droplets in a 3D box trap can be realized in a laboratory thus allowing the study of a large periodic lattice of dipolar droplets in free space bounded by rigid walls.
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- 2022
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223. Stochastic strategies for patrolling a terrain with a synchronized multi-robot system
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Caraballo, Luis E., Díaz-Báñez, José M., Fabila-Monroy, Ruy, and Hidalgo-Toscan, Carlos
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Computer Science - Robotics ,Computer Science - Computational Geometry - Abstract
A group of cooperative aerial robots can be deployed to efficiently patrol a terrain, in which each robot flies around an assigned area and shares information with the neighbors periodically in order to protect or supervise it. To ensure robustness, previous works on these synchronized systems propose sending a robot to the neighboring area in case it detects a failure. In order to deal with unpredictability and to improve on the efficiency in the deterministic patrolling scheme, this paper proposes random strategies to cover the areas distributed among the agents. First, a theoretical study of the stochastic process is addressed in this paper for two metrics: the \emph{idle time}, the expected time between two consecutive observations of any point of the terrain and the \emph{isolation time}, the expected time that a robot is without communication with any other robot. After that, the random strategies are experimentally compared with the deterministic strategy adding another metric: the \emph{broadcast time}, the expected time elapsed from the moment a robot emits a message until it is received by all the other robots of the team. The simulations show that theoretical results are in good agreement with the simulations and the random strategies outperform the behavior obtained with the deterministic protocol proposed in the literature.
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- 2022
224. Correction: Mercury bioaccumulation in bats in Madre de Dios, Peru: implications for Hg bioindicators for tropical ecosystems impacted by artisanal and small-scale gold mining
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Portillo, Alejandro, Vega, Claudia M., Mena, Jose Luis, Bonifaz, Emilio, Ascorra, Cesar, Silman, Miles R., and Fernandez, Luis E.
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- 2024
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225. Gleaning Museum Visitors' Behaviors by Analyzing Questions Asked in a Mobile App
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Pérez Cortés, Luis E., Ha, Jesse, Su, Man, Nelson, Brian, Bowman, Catherine, and Bowman, Judd
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This study explores the feasibility of forming detailed inferences about museum visitor behavior based on analysis of data collected via "Dr. Discovery"--a mobile question-and-answer app. We analyzed 5656 questions asked by 795 visitor groups recorded by Dr. Discovery across two museums in the American Southwest. Analysis of this data supported the act of intuiting visitor movement through museum exhibit halls without the use of costly tracking or location technology by leveraging question keyword content, knowledge of exhibit hall layout, and question timestamp information. Additionally, data on question topic frequency enabled us to infer visitor engagement levels with specific exhibit hall content. We conclude that analysis of seemingly limited app-based data carries implications for the practice of museum evaluation since evaluators can gain evidence-based insight into visitor behaviors as well as illustrate helpful and promising technology-supported alternatives for conducting affordable, dependable, and scalable evaluations.
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- 2023
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226. Understanding museum visitors’ question-asking through a mobile app
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Su, Man, Ha, Jesse, Cortés, Luis E. Pérez, Bernier, Jeremy, Yan, Lin, Nelson, Brian C., Bowman, Judd D., and Bowman, Catherine D. D.
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- 2023
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227. Carotid Artery Tortuosity and Internal Carotid Artery Plaque Composition
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Benson, John C., Shahid, Adnan, Larson, Anthony, Brinjikji, Waleed, Nasr, Deena, Saba, Luca, Lanzino, Giuseppe, and Savastano, Luis E.
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- 2023
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228. The triglycerides and glucose index is highly associated with non-alcoholic fatty liver disease in overweight and obese women
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Rodríguez-Hernández, Heriberto and Simental-Mendía, Luis E.
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- 2023
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229. A Cross-sectional Study of the Mental Health Symptoms of Latin American, US Hispanic, and Spanish College Students Amid the COVID-19 Pandemic
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Torres, Andy, Palomin, Amanda, Morales, Frances, Sevilla-Matos, Maria, Colunga-Rodríguez, Cecilia, Ángel-González, Mario, Sarabia-López, Luis E., Dávalos-Picazo, Gabriel, Delgado-García, Diemen, Duclos-Bastías, Daniel, Vazquez-Colunga, Julio Cesar, Vazquez-Juarez, Claudia Liliana, Egea-Romero, María Pilar, and Mercado, Alfonso
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- 2023
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230. Transport of non-classical light mediated by topological domain walls in a SSH photonic lattice
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Gabriel O’Ryan Pérez, Joaquín Medina Dueñas, Diego Guzmán-Silva, Luis E. F. Foa Torres, and Carla Hermann-Avigliano
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Medicine ,Science - Abstract
Abstract Advancements in photonics technologies have significantly enhanced their capability to facilitate experiments involving quantum light, even at room temperature. Nevertheless, fully integrating photonic chips that include quantum light sources, effective manipulation and transport of light minimizing losses, and appropriate detection systems remains an ongoing challenge. Topological photonic systems have emerged as promising platforms to protect quantum light properties during propagation, beyond merely preserving light intensity. In this work, we delve into the dynamics of non-classical light traversing a Su-Schrieffer-Heeger photonic lattice with topological domain walls. Our focus centers on how topology influences the quantum properties of light as it moves across the array. By precisely adjusting the spacing between waveguides, we achieve dynamic repositioning and interaction of domain walls, facilitating effective beam-splitting operations. Our findings demonstrate high-fidelity transport of non-classical light across the lattice, replicating known results that are now safeguarded by the topology of the system. This protection is especially beneficial for quantum communication protocols with continuous variable states. Our study enhances the understanding of light dynamics in topological photonic systems and paves the way for high-fidelity, topology-protected quantum communication.
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- 2024
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231. Optimal Design of a Hybrid Solar–Battery–Diesel System: A Case Study of Galapagos Islands
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Luis E. Garces-Palacios, Carlos D. Rodríguez-Gallegos, Fernando Vaca-Urbano, Manuel S. Alvarez-Alvarado, Oktoviano Gandhi, and César A. Rodríguez-Gallegos
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off-grid system optimization ,photovoltaic systems ,particle swarm optimization ,Galapagos Islands ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
In this study, the sizing problem of hybrid diesel–photovoltaic–battery systems was determined using a particle swarm optimization approach. The goal was to optimize the number of solar panels and batteries that could be installed to reduce the overall cost of an isolated grid system, originally powered by diesel generators, located on Isabela Island in the Galapagos, Ecuador. In this study, real solar radiation and temperature profiles were used, as well as the load demand and electrical distribution system relative to this island. The results reveal that the total cost for the proposed approach is lower as it reaches the global optimal solution. It also highlights the advantage of a hybrid diesel–photovoltaic–battery (DG-PV-BAT) system compared to conventional systems operated exclusively by diesel generators (DGs) and systems made up of DGs and PV panels; compared to them, a reduction in diesel consumption and total cost (71% and 56%, respectively) is achieved. The DG-PV-BAT system also considerably improves environmental factors and the quality of the power line. This study demonstrates the advantages of hybridizing systems isolated from the network through the proposed approach.
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- 2024
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232. Comparative benefits and harms of perioperative interventions to prevent chronic pain after orthopedic surgery: a systematic review and network meta-analysis of randomized trials
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Mohammed Al-Asadi, Kian Torabiardakani, Andrea J. Darzi, Ian Gilron, Maura Marcucci, James S. Khan, Luis E. Chaparro, Brittany N. Rosenbloom, Rachel J. Couban, Andrew Thomas, Jason W. Busse, and Behnam Sadeghirad
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Chronic postsurgical pain ,Comparative effectiveness ,Systematic review ,Orthopedic surgery ,Musculoskeletal surgery ,Medicine - Abstract
Abstract Background Chronic postsurgical pain (CPSP) is common following musculoskeletal and orthopedic surgeries and is associated with impairment and reduced quality of life. Several interventions have been proposed to reduce CPSP; however, there remains uncertainty regarding which, if any, are most effective. We will perform a systematic review and network meta-analysis of randomised trials to assess the comparative benefits and harms of perioperative pharmacological and psychological interventions directed at preventing chronic pain after musculoskeletal and orthopedic surgeries. Methods We will search MEDLINE, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials from inception to present, without language restrictions. We will include randomised controlled trials that as follows: (1) enrolled adult patients undergoing musculoskeletal or orthopedic surgeries; (2) randomized them to any pharmacological or psychological interventions, or their combination directed at reducing CPSP, placebo, or usual care; and (3) assessed pain at 3 months or more after surgery. Screening for eligible trials, data extraction, and risk-of-bias assessment using revised Cochrane risk-of-bias tool (RoB 2.0) will be performed in duplicate and independently. Our main outcome of interest will be the proportion of surgical patients reporting any pain at ≥ 3 months after surgery. We will also collect data on other patient important outcomes, including pain severity, physical functioning, emotional functioning, dropout rate due to treatment-related adverse event, and overall dropout rate. We will perform a frequentist random-effects network meta-analysis to determine the relative treatment effects. When possible, the modifying effect of sex, surgery type and duration, anesthesia type, and veteran status on the effectiveness of interventions will be investigated using network meta-regression. We will use the GRADE approach to assess the certainty evidence and categorize interventions from most to least beneficial using GRADE minimally contextualised approach. Discussion This network meta-analysis will assess the comparative effectiveness of pharmacological and psychological interventions directed at preventing CPSP after orthopedic surgery. Our findings will inform clinical decision-making and identify promising interventions for future research. Systematic review registration PROSPERO CRD42023432503.
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- 2024
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233. Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
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Ander Puyalto, María Rodríguez-Remírez, Inés López, Irati Macaya, Elizabeth Guruceaga, María Olmedo, Anna Vilalta-Lacarra, Connor Welch, Sergio Sandiego, Silvestre Vicent, Karmele Valencia, Alfonso Calvo, Ruben Pio, Luis E. Raez, Christian Rolfo, Daniel Ajona, and Ignacio Gil-Bazo
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KRAS-mutant lung adenocarcinoma ,Trametinib ,Id1 ,PD-1 inhibition ,PD-L1 ,Proteasome ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS lung adenocarcinoma (LUAD) is a challenge. This study analyzes the effects of trametinib on Id1 protein, a key factor involved in the KRAS oncogenic pathway, and investigates the role of Id1 in the acquired resistance to trametinib as well as the synergistic anticancer effect of trametinib combined with immunotherapy in KRAS-mutant LUAD. Methods We evaluated the effects of trametinib on KRAS-mutant LUAD by Western blot, RNA-seq and different syngeneic mouse models. Genetic modulation of Id1 expression was performed in KRAS-mutant LUAD cells by lentiviral or retroviral transductions of specific vectors. Cell viability was assessed by cell proliferation and colony formation assays. PD-L1 expression and apoptosis were measured by flow cytometry. The anti-tumor efficacy of the combined treatment with trametinib and PD-1 blockade was investigated in KRAS-mutant LUAD mouse models, and the effects on the tumor immune infiltrate were analyzed by flow cytometry and immunohistochemistry. Results We found that trametinib activates the proteasome-ubiquitin system to downregulate Id1 in KRAS-mutant LUAD tumors. Moreover, we found that Id1 plays a major role in the acquired resistance to trametinib treatment in KRAS-mutant LUAD cells. Using two preclinical syngeneic KRAS-mutant LUAD mouse models, we found that trametinib synergizes with PD-1/PD-L1 blockade to hamper lung cancer progression and increase survival. This anti-tumor activity depended on trametinib-mediated Id1 reduction and was associated with a less immunosuppressive tumor microenvironment and increased PD-L1 expression on tumor cells. Conclusions Our data demonstrate that Id1 expression is involved in the resistance to trametinib and in the synergistic effect of trametinib with anti-PD-1 therapy in KRAS-mutant LUAD tumors. These findings suggest a potential therapeutic approach for immunotherapy-refractory KRAS-mutant lung cancers. Graphical Abstract
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- 2024
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234. Voltage-based magnetization switching and reading in magnetoelectric spin-orbit nanodevices
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Diogo C. Vaz, Chia-Ching Lin, John J. Plombon, Won Young Choi, Inge Groen, Isabel C. Arango, Andrey Chuvilin, Luis E. Hueso, Dmitri E. Nikonov, Hai Li, Punyashloka Debashis, Scott B. Clendenning, Tanay A. Gosavi, Yen-Lin Huang, Bhagwati Prasad, Ramamoorthy Ramesh, Aymeric Vecchiola, Manuel Bibes, Karim Bouzehouane, Stephane Fusil, Vincent Garcia, Ian A. Young, and Fèlix Casanova
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Science - Abstract
Abstract As CMOS technologies face challenges in dimensional and voltage scaling, the demand for novel logic devices has never been greater, with spin-based devices offering scaling potential, at the cost of significantly high switching energies. Alternatively, magnetoelectric materials are predicted to enable low-power magnetization control, a solution with limited device-level results. Here, we demonstrate voltage-based magnetization switching and reading in nanodevices at room temperature, enabled by exchange coupling between multiferroic BiFeO3 and ferromagnetic CoFe, for writing, and spin-to-charge current conversion between CoFe and Pt, for reading. We show that, upon the electrical switching of the BiFeO3, the magnetization of the CoFe can be reversed, giving rise to different voltage outputs. Through additional microscopy techniques, magnetization reversal is linked with the polarization state and antiferromagnetic cycloid propagation direction in the BiFeO3. This study constitutes the building block for magnetoelectric spin-orbit logic, opening a new avenue for low-power beyond-CMOS technologies.
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- 2024
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235. Acrodermatitis dysmetabolica with concomitant acquired acrodermatitis enteropathica in a patient with maple syrup urine disease
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Luis E. Santaliz-Ruiz, IV, MD, Angélica C. Marrero-Pérez, MD, Julio Sánchez-Pont, MD, and Oscar Nevárez-Pomales, MD
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acrodermatitis dysmetabolica ,acrodermatitis enteropathica ,maple syrup urine disease ,skin manifestations in nutritional deficiencies ,zinc deficiency ,Dermatology ,RL1-803 - Published
- 2024
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236. Mechanical Design of a New Hybrid 3R-DoF Bioinspired Robotic Fin Based on Kinematics Modeling and Analysis
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Eliseo de J. Cortés Torres, Luis E. García Gonzales, Luis E. Villamizar Marin, and Cecilia E. García Cena
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bioinspired ,compliant joints ,underwater robots ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Production of electric energy or power. Powerplants. Central stations ,TK1001-1841 - Abstract
The field of bioinspired underwater robots aims to replicate the capabilities of marine animals in artificial systems. Stingrays have emerged as highly promising species to be mimicked because of their flat body morphology and size. Furthermore, they are considered high-performance species due to their maneuverability, propulsion mode, and sliding efficiency. Designing and developing mechanisms to imitate their pectoral fins is a challenge for underwater robotic researchers mainly because the locomotion characteristics depend on the coordinated movement of the fins. In the state of the art, several mechanisms were proposed with 2 active rotation degrees of freedom (DoFs) to replicate fin movement. In this paper, we propose adding an additional active DoF in order to improve the realism in the robotic manta ray movement. Therefore, in this article, we present the mechanical design, modeling, and kinematics analysis of a 3-active-and-rotational-DoF pectoral fin inspired by the Mobula Alfredi or reef manta ray. Additionally, by using the kinematics model, we were able to simulate and compare the behaviour of both mechanisms, that is, those with 2 and 3 DoFs. Our simulation results reveal an improvement in the locomotion, and we hypothesized that with the third DoF, some specific missions, such as hovering or fast emergence to the surface, will have a better performance.
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- 2024
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237. Inversion maps and torus actions on rational homogeneous varieties
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Franceschini, Alberto and Conde, Luis E. Solá
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Mathematics - Algebraic Geometry ,Primary 14L30, Secondary 14E30, 14L24, 14M17 - Abstract
Complex projective algebraic varieties with $\mathbb{C}^*$-actions can be thought of as geometric counterparts of birational transformations. In this paper we describe geometrically the birational transformations associated to rational homogeneous varieties endowed with a $\mathbb{C}^*$-action with no proper isotropy subgroups.
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- 2022
238. Production of PBHs from inflaton structure
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Hidalgo, Juan Carlos, Padilla, Luis E., and German, Gabriel
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
At times prior to Big Bang Nucleosynthesis, the universe could show a primordial structure formation period if dominated by a fast oscillating inflaton field during reheating. In this context, we have postulated a new mechanism of primordial black hole formation [L. E. Padilla, J. C. Hidalgo, and K. A. Malik, Phys. Rev. D, vol. 106, p. 023519, Jul 2022], that draws the analogy between an extended reheating era and the scalar field dark matter model, stipulating the gravitational collapse of inflaton halos and inflaton stars. In this paper we look at the requirements for the realization of this new mechanism. We show that a generic primordial power spectrum with a peak at small scales is most suitable for the production of a considerable number of PBHs. When such requirement is met, and if reheating lasts long enough, large populations of PBHs with $M_{\rm PBH}\sim 1~\mathrm{gram}$ may be produced. We find in particular, that the mass fraction of PBHs is orders of magnitude larger than that obtained when PBHs form via direct collapse in a universe dominated by radiation or pressure-less dust. Looking at observable implications of our findings, we explore the possibility that the PBHs component may dominate the energy density of the universe at some point after the end of reheating., Comment: 11 pages, 5 figures. Accepted for publication in PRD
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- 2022
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239. LargeNetVis: Visual Exploration of Large Temporal Networks Based on Community Taxonomies
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Linhares, Claudio D. G., Ponciano, Jean R., Pedro, Diogenes S., Rocha, Luis E. C., Traina, Agma J. M., and Poco, Jorge
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Computer Science - Human-Computer Interaction - Abstract
Temporal (or time-evolving) networks are commonly used to model complex systems and the evolution of their components throughout time. Although these networks can be analyzed by different means, visual analytics stands out as an effective way for a pre-analysis before doing quantitative/statistical analyses to identify patterns, anomalies, and other behaviors in the data, thus leading to new insights and better decision-making. However, the large number of nodes, edges, and/or timestamps in many real-world networks may lead to polluted layouts that make the analysis inefficient or even infeasible. In this paper, we propose LargeNetVis, a web-based visual analytics system designed to assist in analyzing small and large temporal networks. It successfully achieves this goal by leveraging three taxonomies focused on network communities to guide the visual exploration process. The system is composed of four interactive visual components: the first (Taxonomy Matrix) presents a summary of the network characteristics, the second (Global View) gives an overview of the network evolution, the third (a node-link diagram) enables community- and node-level structural analysis, and the fourth (a Temporal Activity Map -- TAM) shows the community- and node-level activity under a temporal perspective., Comment: 11 pages, 9 figures
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- 2022
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240. Floquet topological phase transitions in a periodically quenched dimer
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Jangjan, Milad, Torres, Luis E. F. Foa, and Hosseini, Mir Vahid
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We report on the theoretical investigation of the topological properties of a periodically quenched one-dimensional dimerized lattice where a piece-wise constant Hamiltonian switches from $h_1$ to $h_2$ at a partition time $t_p$ within each driving period $T$. We examine different dimerization patterns for $h_1$ and $h_2$ and the interplay with the driving parameters that lead to the emergence of topological states both at zero energy and at the edge of the Brillouin-Floquet quasi-energy zone. We illustrate different phenomena, including the occurrence of both edge states in a semimetal spectrum, the topological transitions, and the generation of zero-energy topological states from trivial snapshots. The role of the different symmetries in our results is also discussed., Comment: 13 pages, 10 figures
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- 2022
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241. Bring the BitCODE -- Moving Compute and Data in Distributed Heterogeneous Systems
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Lu, Wenbin, Peña, Luis E., Shamis, Pavel, Churavy, Valentin, Chapman, Barbara, and Poole, Steve
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Networking and Internet Architecture - Abstract
In this paper, we present a framework for moving compute and data between processing elements in a distributed heterogeneous system. The implementation of the framework is based on the LLVM compiler toolchain combined with the UCX communication framework. The framework can generate binary machine code or LLVM bitcode for multiple CPU architectures and move the code to remote machines while dynamically optimizing and linking the code on the target platform. The remotely injected code can recursively propagate itself to other remote machines or generate new code. The goal of this paper is threefold: (a) to present an architecture and implementation of the framework that provides essential infrastructure to program a new class of disaggregated systems wherein heterogeneous programming elements such as compute nodes and data processing units (DPUs) are distributed across the system, (b) to demonstrate how the framework can be integrated with modern, high-level programming languages such as Julia, and (c) to demonstrate and evaluate a new class of eXtended Remote Direct Memory Access (X-RDMA) communication operations that are enabled by this framework. To evaluate the capabilities of the framework, we used a cluster with Fujitsu CPUs and heterogeneous cluster with Intel CPUs and BlueField-2 DPUs interconnected using high-performance RDMA fabric. We demonstrated an X-RDMA pointer chase application that outperforms an RDMA GET-based implementation by 70% and is as fast as Active Messages, but does not require function predeployment on remote platforms., Comment: 11 pages, 12 figures, to be published in IEEE CLUSTER 2022
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- 2022
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242. Evolution of the public opinion on COVID-19 vaccination in Japan
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Nakayama, Yuri, Takedomi, Yuka, Suda, Towa, Uno, Takeaki, Hashimoto, Takako, Toyoda, Masashi, Yoshinaga, Naoki, Kitsuregawa, Masaru, Rocha, Luis E. C., and Kobayashi, Ryota
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Physics - Physics and Society ,Computer Science - Social and Information Networks - Abstract
Vaccines are promising tools to control the spread of COVID-19. An effective vaccination campaign requires government policies and community engagement, sharing experiences for social support, and voicing concerns to vaccine safety and efficiency. The increasing use of online social platforms allows us to trace large-scale communication and infer public opinion in real-time. We collected more than 100 million vaccine-related tweets posted by 8 million users and used the Latent Dirichlet Allocation model to perform automated topic modeling of tweet texts during the vaccination campaign in Japan. We identified 15 topics grouped into 4 themes on Personal issue, Breaking news, Politics, and Conspiracy and humour. The evolution of the popularity of themes revealed a shift in public opinion, initially sharing the attention over personal issues (individual aspect), collecting information from the news (knowledge acquisition), and government criticisms, towards personal experiences once confidence in the vaccination campaign was established. An interrupted time series regression analysis showed that the Tokyo Olympic Games affected public opinion more than other critical events but not the course of the vaccination. Public opinion on politics was significantly affected by various events, positively shifting the attention in the early stages of the vaccination campaign and negatively later. Tweets about personal issues were mostly retweeted when the vaccination reached the younger population. The associations between the vaccination campaign stages and tweet themes suggest that the public engagement in the social platform contributed to speedup vaccine uptake by reducing anxiety via social learning and support.
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- 2022
243. Rubisco function, evolution, and engineering
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Prywes, Noam, Phillips, Naiya R, Tuck, Owen T, Valentin-Alvarado, Luis E, and Savage, David F
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Quantitative Biology - Biomolecules - Abstract
Carbon fixation is the process by which CO2 is converted from a gas into biomass. The Calvin Benson Bassham (CBB) cycle is the dominant carbon fixation pathway on earth, driving >99.5% of the ~120 billion tons of carbon that are "fixed" as sugar, by plants, algae and cyanobacteria. The carboxylase enzyme in the CBB, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco), fixes one CO2 molecule per turn of the cycle. Despite being critical to the assimilation of carbon, rubisco's kinetic rate is not very fast and it is a bottleneck in flux through the pathway. This presents a paradox - why hasn't rubisco evolved to be a better catalyst? Many hypothesize that the catalytic mechanism of rubisco is subject to one or more trade-offs, and that rubisco variants have been optimized for their native physiological environment. Here we review the evolution and biochemistry of rubisco through the lens of structure and mechanism in order to understand what trade-offs limit its improvement. We also review the many attempts to improve rubisco itself and, thereby, promote plant growth.
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- 2022
244. Mori Dream Pairs and $\mathbb{C}^*$-actions
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Barban, Lorenzo, Romano, Eleonora A., Conde, Luis E. Solá, and Urbinati, Stefano
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Mathematics - Algebraic Geometry ,Primary 14L30, Secondary 14E30, 14L24, 14M17 - Abstract
We construct a correspondence between Mori dream regions arising from small modifications of normal projective varieties and $\mathbb{C}^*$-actions on polarized pairs which are bordisms. Moreover, we show that the Mori dream regions constructed in this way admit a chamber decomposition on which the models are the geometric quotients of the $\mathbb{C}^*$-action. In addition we construct, from a given $\mathbb{C}^*$-action on a polarized pair for which there exist at least two admissible geometric quotients, a $\mathbb{C}^*$-equivariantly birational $\mathbb{C}^*$-variety, whose induced action is a bordism, called the pruning of the variety., Comment: 20 pages, 2 figures
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- 2022
245. A comparative study of different machine learning methods for dissipative quantum dynamics
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Rodriguez, Luis E. Herrera, Ullah, Arif, Espinosa, Kennet J. Rueda, Dral, Pavlo O., and Kananenka, Alexei A.
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Quantum Physics ,Physics - Computational Physics - Abstract
It has been recently shown that supervised machine learning (ML) algorithms can accurately and efficiently predict the long-time populations dynamics of dissipative quantum systems given only short-time population dynamics. In the present article we benchmaked 22 ML models on their ability to predict long-time dynamics of a two-level quantum system linearly coupled to harmonic bath. The models include uni- and bidirectional recurrent, convolutional, and fully-connected feed-forward artificial neural networks (ANNs) and kernel ridge regression (KRR) with linear and most commonly used nonlinear kernels. Our results suggest that KRR with nonlinear kernels can serve as inexpensive yet accurate way to simulate long-time dynamics in cases where the constant length of input trajectories is appropriate. Convolutional Gated Recurrent Unit model is found to be the most efficient ANN model., Comment: 22 pages, 6 figures
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- 2022
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246. Effect of quartic-quintic beyond-mean-field interactions on a self-bound dipolar droplet
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Young-S., Luis E. and Adhikari, S. K.
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Condensed Matter - Quantum Gases - Abstract
We study the effect of beyond-mean-field quantum-fluctuation (QF) Lee-Huang-Yang (LHY) and three-body interactions, with quartic and quintic nonlinearities, respectively, on the formation of a stable self-repulsive (positive scattering length $a$) and a self-attractive (negative $a$) self-bound dipolar Bose-Einstein condensate (BEC) droplet in free space under the action of two-body contact and dipolar interactions. Previous studies of dipolar droplets considered either the LHY interaction or the three-body interaction, as either of these interactions could stabilize a dipolar BEC droplet against collapse. We find that the effect of three-body recombination on the formation of a dipolar droplet could be quite large and for a complete description of the problem both the QF LHY and three-body interactions should be considered simultaneously, where appropriate. In the self-repulsive case for small $a$ and in the self-attractive case, no appropriate LHY interaction is known and only three-body interaction should be used, otherwise both beyond-mean-field interactions should be used. We consider a numerical solution of a highly-nonlinear beyond-mean-field model as well as a variational approximation to it in this investigation and present results for size, shape and energy of a dipolar droplet of polarized $^{164}$Dy atoms. The shape is filament-like, along the polarization direction, and could be long, for a large number of atoms $N$, short for small $N$, thin for negative $a$ and small positive $a$, and fat for large positive $a$.
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- 2022
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247. AAM-Gym: Artificial Intelligence Testbed for Advanced Air Mobility
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Brittain, Marc, Alvarez, Luis E., Breeden, Kara, and Jessen, Ian
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Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Signal Processing - Abstract
We introduce AAM-Gym, a research and development testbed for Advanced Air Mobility (AAM). AAM has the potential to revolutionize travel by reducing ground traffic and emissions by leveraging new types of aircraft such as electric vertical take-off and landing (eVTOL) aircraft and new advanced artificial intelligence (AI) algorithms. Validation of AI algorithms require representative AAM scenarios, as well as a fast time simulation testbed to evaluate their performance. Until now, there has been no such testbed available for AAM to enable a common research platform for individuals in government, industry, or academia. MIT Lincoln Laboratory has developed AAM-Gym to address this gap by providing an ecosystem to develop, train, and validate new and established AI algorithms across a wide variety of AAM use-cases. In this paper, we use AAM-Gym to study the performance of two reinforcement learning algorithms on an AAM use-case, separation assurance in AAM corridors. The performance of the two algorithms is demonstrated based on a series of metrics provided by AAM-Gym, showing the testbed's utility to AAM research., Comment: 10 pages, accepted for publication in 2022 IEEE/AIAA Digital Avionics Systems Conference
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- 2022
248. Ultra–Low-Dose Radiation for Extranodal Marginal Zone Lymphoma of the Lung
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Susan Y. Wu, MD, Penny Q. Fang, MD, MBA, Ahmed Fetooh, MBBS, Gohar S. Manzar, MD, PhD, Kelsey L. Corrigan, MD, MPH, Benjamin R. Schrank, MD, PhD, Lewis Nasr, MD, MS, Dai Chihara, MD, PhD, Luis E. Malpica Castillo, MD, Ranjit Nair, MD, Raphael E. Steiner, MD, Preetesh Jain, MBBS, MD, DM, PhD, Sattva S. Neelapu, MD, Paolo Strati, MD, Loretta J. Nastoupil, MD, Bouthaina S. Dabaja, MD, Chelsea C. Pinnix, MD, PhD, and Jillian R. Gunther, MD, PhD
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Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: Definitive intent radiation therapy (RT) for early-stage mucosa-associated lymphoid tissue (MALT) lymphoma typically includes a dose of 24 to 30 Gy. While modest, these doses may have associated toxicity. For patients with indolent B-cell lymphoma, there is increasing support for the use of ultra–low-dose RT (ULDRT) using 4 Gy in 2 fractions as part of a response-adapted approach, as high rates of complete response have been documented. This paradigm has been prospectively evaluated in the management of orbital and gastric indolent B-cell lymphomas; however, there is limited data guiding the use of ULDRT for lung MALT. Methods: We conducted a retrospective review of 20 patients at our institution with lung MALT treated with ULDRT as part of a response-adapted approach. Clinical variables including prior systemic therapy and symptoms were abstracted from the electronic health record. Responses were assessed using the revised Lugano criteria. Results: At a median follow up of 17 months following 4 Gy (IQR, 8-37 months), we observed 100% local control. Nineteen patients (95%) experienced a complete response. No patients with stage IE disease at RT (17/20; 85%) experienced distant progression. Nine patients (45%) were symptomatic prior to RT, with improvement or resolution of symptoms in 7 (7/9; 78%). One patient developed grade 2 pleuritic pain following RT, which resolved with a brief course of steroids. No other toxicities were noted. Conclusions: ULDRT, given in a response-adapted approach, is effective and well tolerated by patients with lung MALT.
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- 2024
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249. Design of a low-cost force insoles to estimate ground reaction forces during human gait
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Nelson E. Guevara, Carlos F. Rengifo, Yamir H. Bolaños, Daniel A. Fernández, Wilson A. Sierra, and Luis E. Rodríguez
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Ground reaction forces ,Force insoles ,Piezo-resistive sensors ,ESP32 microcontrollers ,Low-cost ,3D printing ,Science (General) ,Q1-390 - Abstract
This paper proposes a low-cost electronic system for estimating ground reaction forces (GRF) during human gait. The device consists of one master node and two slave nodes. The master node sends instructions to slave nodes that sample and store data from two force insoles located at the participant’s feet. These insoles are equipped with 14 piezo-resistive FlexiForce A301 sensors (FSR). The slave nodes are attached to the ankles and feet of each participant. Subsequently, the start command is transmitted through the master node, which is connected to the USB port of a personal computer (PC). Once the walking session is completed, the information obtained by the slave nodes can be downloaded by accessing the access point generated by these devices through Wi-Fi communication. The GRF estimation system was validated with force platforms (BTS Bioengineering P6000, Italy), giving on average a fit measure equal to 68.71%±4.80% in dynamic situations. Future versions of this device are expected to increase this fit by using machine learning models.
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- 2024
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250. Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort
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Elizabeth C. Anderson, Helen B. Foley, Joshua J. Levy, Megan E. Romano, Jiang Gui, Jessica L. Bentz, Luis E. Maldonado, Shohreh F. Farzan, Theresa M. Bastain, Carmen J. Marsit, Carrie V. Breton, and Caitlin G. Howe
- Subjects
miRNA ,glucose ,diabetes ,pregnancy ,Genetics ,QH426-470 - Abstract
Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p
- Published
- 2024
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