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975 results on '"Lucas, Andrew"'

204. Dinoflagellate vertical migration fuels an intense red tide.

Author

Bofu Zheng, Lucas, Andrew J., Franks, Peter J. S., Schlosser, Tamara L., Anderson, Clarissa R., Send, Uwe, Davis, Kristen, Barton, Andrew D., and Sosik, Heidi M.

Subjects
*RED tide, *ALGAL blooms, *BIOMASS, *TERRITORIAL waters, *DINOFLAGELLATES, *VERTICAL integration
Abstract

Harmful algal blooms (HABs) are increasing globally, causing economic, human health, and ecosystem harm. In spite of the frequent occurrence of HABs, the mechanisms responsible for their exceptionally high biomass remain imperfectly understood. A 50-y- old hypothesis posits that some dense blooms derive from dinoflagellate motility: organisms swim upward during the day to photosynthesize and downward at night to access deep nutrients. This allows dinoflagellates to outgrow their nonmotile competitors. We tested this hypothesis with in situ data from an autonomous, ocean-wave- powered vertical profiling system. We showed that the dinoflagellate Lingulodinium polyedra’s vertical migration led to depletion of deep nitrate during a 2020 red tide HAB event. Downward migration began at dusk, with the maximum migration depth determined by local nitrate concentrations. Losses of nitrate at depth were balanced by proportional increases in phytoplankton chlorophyll concentrations and suspended particle load, conclusively linking vertical migration to the access and assimilation of deep nitrate in the ocean environment. Vertical migration during the red tide created anomalous biogeochemical conditions compared to 70 y of climatological data, demonstrating the capacity of these events to temporarily reshape the coastal ocean’s ecosystem and biogeochemistry. Advances in the understanding of the physiological, behavioral, and metabolic dynamics of HAB-forming organisms from cutting-edge observational techniques will improve our ability to forecast HABs and mitigate their consequences in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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209. The inspection of level crossing rails using guided waves

Author

Evansa, Mark, Lucas, Andrew, and Ingram, Ian

Subjects
Traffic engineering -- Analysis, Corrosion (Chemistry) -- Analysis, Building materials -- Chemical properties -- Analysis, Business, Construction and materials industries
Abstract

ABSTRACT Level crossing rails are high risk areas due to the combination of the limited effectiveness of current inspection methods and high corrosion rates which often exist. This paper discusses [...]

Published
2018
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212. P2.13: Immunosuppression Monotherapy Does Not Protect Donor Leukocytes From Depletion Post MHC-Mismatched Kidney Transplantation in Mice

Author

Dart, Sarah, primary, O’Halloran, Sean, additional, Liu, Liu, additional, Huang, Wen Hua, additional, Kaur, Jaskirat, additional, Zhang, Xiao, additional, Prosser, Amy, additional, Watson, Monalyssa, additional, Lucas, Andrew, additional, Jeffrey, Gary, additional, Joyce, David, additional, and Lucas, Michaela, additional

Published
2022
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214. Imaging the Breakdown of Ohmic Transport in Graphene

Author

Jenkins, Alec, primary, Baumann, Susanne, additional, Zhou, Haoxin, additional, Meynell, Simon A., additional, Daipeng, Yang, additional, Watanabe, Kenji, additional, Taniguchi, Takashi, additional, Lucas, Andrew, additional, Young, Andrea F., additional, and Bleszynski Jayich, Ania C., additional

Published
2022
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216. Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis

Author

Prêle, Cecilia M., primary, Miles, Tylah, additional, Pearce, David R., additional, O'Donoghue, Robert J., additional, Grainge, Chris, additional, Barrett, Lucy, additional, Birnie, Kimberly, additional, Lucas, Andrew D., additional, Baltic, Svetlana, additional, Ernst, Matthias, additional, Rinaldi, Catherine, additional, Laurent, Geoffrey J., additional, Knight, Darryl A., additional, Fear, Mark, additional, Hoyne, Gerard, additional, McAnulty, Robin J., additional, and Mutsaers, Steven E., additional

Published
2022
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221. On the Development of SWOT In Situ Calibration/Validation for Short-Wavelength Ocean Topography

Author

Wang, Jinbo, primary, Fu, Lee-Lueng, additional, Haines, Bruce, additional, Lankhorst, Matthias, additional, Lucas, Andrew J., additional, Farrar, J. Thomas, additional, Send, Uwe, additional, Meinig, Christian, additional, Schofield, Oscar, additional, Ray, Richard, additional, Archer, Matthew, additional, Aragon, David, additional, Bigorre, Sebastien, additional, Chao, Yi, additional, Kerfoot, John, additional, Pinkel, Robert, additional, Sandwell, David, additional, and Stalin, Scott, additional

Published
2022
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223. Evaluating a Holonic Packing Cell

Author

Fletcher, Martyn, McFarlane, Duncan, Thorne, Alan, Jarvis, Dennis, Lucas, Andrew, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Mařík, Vladimír, editor, McFarlane, Duncan, editor, and Valckenaers, Paul, editor

Published
2003
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226. Supplemental Material—The patient acceptability of a remotely delivered pain management programme for people with persistent musculoskeletal pain: A qualitative evaluation

Author

Booth, Gregory, Zala, Sonia, Mitchell, Chloe, Zarnegar, Roxaneh, Lucas, Andrew, and Gilbert, Anthony W

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental Material for The patient acceptability of a remotely delivered pain management programme for people with persistent musculoskeletal pain: A qualitative evaluation by Gregory Booth, Sonia Zala, Chloe Mitchell, Roxaneh Zarnegar, Andrew Lucas and Anthony W Gilbert in British Journal of Pain

Published
2022
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227. Investigation of the pharmacokinetic properties of synthetic heparan sulfate oligosaccharides.

Author

Arnold, Katelyn, Wang, Zhangjie, Lucas, Andrew, Zamboni, William, Xu, Yongmei, and Liu, Jian

Subjects
LIQUID chromatography-mass spectrometry, HEPARAN sulfate, OLIGOSACCHARIDES, PHARMACOKINETICS, CHONDROITIN sulfates
Abstract

Heparan sulfate (HS) is a sulfated polysaccharide with a wide range of biological activities. There is an increasing interest in the development of structurally homogeneous HS oligosaccharides as therapeutics. However, the factors influencing the pharmacokinetic properties of HS-based therapeutics remain unknown. Here, we report the pharmacokinetic properties of a panel of dodecasaccharides (12-mers) with varying sulfation patterns in healthy mice and uncover the pharmacokinetic properties of an octadecasaccharide (18-mer) in acutely injured mice. In the 12-mer panel, 1 12-mer, known as dekaparin, is anticoagulant, and 3 12-mers are nonanticoagulant. The concentrations of 12-mers in plasma and urine were determined by the disaccharide analysis using liquid chromatography coupled with tandem mass spectrometry. We observed a striking difference between anticoagulant and nonanticoagulant oligosaccharides in the 12-mer panel, showing that anticoagulant dekaparin had a 4.6-fold to 8.6-fold slower clearance and 4.4-fold to 8-fold higher plasma exposure compared to nonanticoagulant 12-mers. We also observed that the clearance of HS oligosaccharides is impacted by disease. Using an antiinflammatory 18-mer, we discovered that the clearance of 18-mer is reduced 2.8-fold in a liver failure mouse model compared to healthy mice. Our results suggest that oligosaccharides are rapidly cleared renally if they have low interaction with circulating proteins. We observed that the clearance rate of oligosaccharides is inversely associated with the degree of binding to target proteins, which can vary in response to pathophysiological conditions. Our findings uncover a contributing factor for the plasma and renal clearance of oligosaccharides which will aid the development of HS-based therapeutics. [ABSTRACT FROM AUTHOR]

Published
2023
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241. Absence of Hyperactivation of Fibrinolysis Explains the Lack of Hemostatic Efficacy of Prophylactic Tranexamic Acid (TXA) in Hypoproliferative Thrombocytopenia

Author

Ilich, Anton, primary, Gernsheimer, Terry B., additional, Triulzi, Darrell J, additional, Herren, Heather, additional, Brown, Siobhan P, additional, Holle, Lori A, additional, Lucas, Andrew T, additional, El Kassar, Nahed, additional, Wolberg, Alisa S., additional, May, Susanne, additional, and Key, Nigel S, additional

Published
2021
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246. Rapid design and implementation of a virtual pain management programme due to COVID-19: a quality improvement initiative

Author

Williams, Deborah, primary, Booth, Gregory, additional, Cohen, Helen, additional, Gilbert, Anthony, additional, Lucas, Andrew, additional, Mitchell, Chloe, additional, Mittal, Gayatri, additional, Patel, Hasina, additional, Peters, Tamsin, additional, Phillips, Mia, additional, Rudge, Will, additional, and Zarnegar, Roxaneh, additional

Published
2021
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