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201. Epidemiology and Genetic Variability of HHV-8/KSHV among Rural Populations and Kaposi’s Sarcoma Patients in Gabon, Central Africa. Review of the Geographical Distribution of HHV-8 K1 Genotypes in Africa

Author: Antony Idam Mamimandjiami, Augustin Mouinga-Ondémé, Jill-Léa Ramassamy, Délia Doreen Djuicy, Philippe V. Afonso, Antoine Mahé, Jean-Bernard Lekana-Douki, Olivier Cassar, Antoine Gessain, Centre International de Recherches Médicales de Franceville (CIRMF), Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Ecole Doctorale Régionale d’Afrique Centrale, Université de Paris (UP), CHPC - Site Louis Pasteur, Centre Hospitalier Public du Cotentin (CHPC), Université des sciences de la santé, This study was supported by the Institut Pasteur in Paris and the 'Centre International de Recherches Médicales de Franceville' (CIRMF) in Gabon (A.I.M.), the CNRS (UMR 3569) (A.G.), the Institut Pasteur, France (A.G.) and through the 'Investissement d’Avenir' as part of a 'Laboratoire d’Excellence' (LabEx) French research program: Integrative Biology of Emerging Infectious Diseases (ANR10-LBX- 62 IBEID) (A.G.). This research was also funded by the European Union (FOOD/2016/379-660) (J.L.R.)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), and Hôpital Louis Pasteur [Colmar] (CH Colmar)
Subjects: Male, Rural Population, viruses, [SDV]Life Sciences [q-bio], lcsh:QR1-502, serology, Antibodies, Viral, lcsh:Microbiology, MESH: Genotype, MESH: Aged, 80 and over, MESH: Rural Population, Seroepidemiologic Studies, genetic variability, MESH: Genetic Variation, MESH: Phylogeny, Antigens, Viral, Phylogeny, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Nuclear Proteins, virus diseases, Middle Aged, MESH: Young Adult, Herpesvirus 8, Human, Female, epidemiology, MESH: Antigens, Viral, Adult, MESH: Gabon, Adolescent, Genotype, KSHV, Article, Viral Proteins, Young Adult, Humans, Gabon, Sarcoma, Kaposi, HHV-8, Aged, MESH: Adolescent, MESH: Herpesvirus 8, Human, MESH: Seroepidemiologic Studies, MESH: Humans, Genetic Variation, MESH: Adult, rural populations Gabon, biochemical phenomena, metabolism, and nutrition, MESH: Viral Proteins, MESH: Male, MESH: DNA, Viral, DNA, Viral, MESH: Sarcoma, Kaposi, MESH: Female, MESH: Nuclear Proteins, MESH: Antibodies, Viral
Abstract: Human herpesvirus 8 (HHV-8) is the etiological agent of all forms of Kaposi&rsquo, s sarcoma (KS). K1 gene studies have identified five major molecular genotypes with geographical clustering. This study described the epidemiology of HHV-8 and its molecular diversity in Gabon among Bantu and Pygmy adult rural populations and KS patients. Plasma antibodies against latency-associated nuclear antigens (LANA) were searched by indirect immunofluorescence. Buffy coat DNA samples were subjected to polymerase chain reaction (PCR) to obtain a K1 gene fragment. We studied 1020 persons, 91% were Bantus and 9% Pygmies. HHV-8 seroprevalence was 48.3% and 36.5% at the 1:40 and 1:160 dilution thresholds, respectively, although the seroprevalence of HHV-8 is probably higher in Gabon. These seroprevalences did not differ by sex, age, ethnicity or province. The detection rate of HHV-8 K1 sequence was 2.6% by PCR. Most of the 31 HHV-8 strains belonged to the B genotype (24), while the remaining clustered within the A5 subgroup (6) and one belonged to the F genotype. Additionally, we reviewed the K1 molecular diversity of published HHV-8 strains in Africa. This study demonstrated a high seroprevalence of HHV-8 in rural adult populations in Gabon and the presence of genetically diverse strains with B, A and also F genotypes.
Published: 2021
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202. Cluster self-assembly condition for arbitrary interaction potentials

Author: Guido Pupillo, Rogelio Díaz-Méndez, Egor Babaev, Alejandro Mendoza-Coto, Rómulo Cenci, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: FOS: Physical sciences, 02 engineering and technology, Condensed Matter - Soft Condensed Matter, 01 natural sciences, Molecular dynamics, symbols.namesake, Interaction potential, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, Low density, Hexagonal lattice, Statistical physics, 010306 general physics, Physics, Condensed Matter - Mesoscale and Nanoscale Physics, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Formalism (philosophy of mathematics), Fourier transform, Bounded function, symbols, Soft Condensed Matter (cond-mat.soft), Self-assembly, 0210 nano-technology
Abstract: We present a sufficient criterion for the emergence of cluster phases in an ensemble of interacting classical particles with repulsive two-body interactions. Through a zero-temperature analysis in the low density region we determine the relevant characteristics of the interaction potential that make the energy of a two-particle cluster-crystal become smaller than that of a simple triangular lattice in two dimensions. The method leads to a mathematical condition for the emergence of cluster crystals in terms of the sum of Fourier components of a regularized interaction potential, which can be in principle applied to any arbitrary shape of interactions. We apply the formalism to several examples of bounded and unbounded potentials with and without cluster-forming ability. In all cases, the emergence of self-assembled cluster crystals is well captured by the presented analytic criterion and verified with known results from molecular dynamics simulations at vanishingly temperatures. Our work generalises known results for bounded potentials to repulsive potentials of arbitrary shape., Comment: 9 pages, 5 figures
Published: 2021
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203. Chemical Conversion and Locking of the Imine Linkage: Enhancing the Functionality of Covalent Organic Frameworks

Author: Artur Ciesielski, Luca Cusin, Paolo Samorì, Hai-Jun Peng, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, Materials science, 010405 organic chemistry, Imine, Dynamic covalent chemistry, Nanotechnology, Context (language use), General Medicine, General Chemistry, Linkage (mechanical), [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, law.invention, chemistry.chemical_compound, chemistry, law, Covalent bond, Chemical conversion, Crystallization
Abstract: International audience; Imine-based covalent organic frameworks (COFs) are a widely studied class of functional, crystalline, and porous nanostructures which combine a relatively facile crystallization with tuneable compositions and porosities. However, the imine linkage constitutes an intrinsic limitation due to its reduced stability in harsh chemical conditions and its unsuitability for in-plane π-conjugation in COFs. Urgent solutions are therefore required in order to exploit the full potential of these materials, thereby enabling their technological application in electronics, sensing, and energy storage devices. In this context, the advent of a new generation of linkages derived from the chemical conversion and locking of the imine bond represents a cornerstone for the synthesis of new COFs. A marked increase in the framework robustness is in fact often combined with the incorporation of novel functionalities including, for some of these reactions, an extension of the in-plane π-conjugation. This Minireview describes the most enlightening examples of one-pot reactions and post-synthetic modifications towards the chemical locking of the imine bond in COFs.
Published: 2021
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204. Enantioselective α-Arylation of Primary Alcohols under Sequential One-Pot Catalysis

Author: Maiia Aleksandrova, Dawid Lichosyt, Bruno Lainer, Paweł Dydio, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), univOAK, Archive ouverte, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nucleophilic addition, Primary (chemistry), Molecular Structure, 010405 organic chemistry, Chemistry, Aryl, Organic Chemistry, Enantioselective synthesis, Halide, Hydrogen transfer, Stereoisomerism, Alkenes, Ketones, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Nucleophile, [CHIM.OTHE] Chemical Sciences/Other, Alcohols, Organic chemistry, [CHIM.OTHE]Chemical Sciences/Other
Abstract: Secondary benzylic alcohols and diarylmethanols are common structural motifs of biologically active and medicinally relevant compounds. Here we report their enantioselective synthesis by α-arylation of primary aliphatic and benzylic alcohols under sequential catalysis integrating a Ru-catalyzed hydrogen transfer oxidation and a Ru-catalyzed nucleophilic addition. The method can be applied to various alcohols and aryl nucleophiles tolerating a range of functional groups, including secondary alcohols, ketones, alkenes, esters, NH amides, tertiary amines, aryl halides, and heterocycles.
Published: 2021
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205. Sedimentation Velocity Methods for the Characterization of Protein Heterogeneity and Protein Affinity Interactions

Author: Ebel, Christine, Birck, Catherine, Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Data Analysis, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Protein interaction, Sedimentation velocity, Temperature, Proteins, Biosensing Techniques, Models, Theoretical, Biophysical Phenomena, Hetero-association, Protein heterogeneity, Sedimentation coefficient, Analytical ultracentrifugation, Ultracentrifugation, Algorithms, Protein Binding
Abstract: International audience; Sedimentation velocity analytical ultracentrifugation is a powerful and versatile tool for the characterization of proteins and macromolecular complexes in solution. The direct modeling of the sedimentation process using modern computational strategies allows among others to assess the homogeneity/heterogeneity state of protein samples and to characterize protein associations. In this chapter, we will provide theoretical backgrounds and protocols to analyze the size distribution of protein samples and to determine the affinity of protein-protein hetero-associations.
Published: 2021
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206. Human Dicer helicase domain recruits PKR and dsRNA binding proteins during viral infection

Author: Montavon, Thomas, Baldaccini, Morgane, Lefèvre, Mathieu, Girardi, Erika, Chane-Woon-Ming, Béatrice, Messmer, Mélanie, Hammann, Philippe, Chicher, Johana, Pfeffer, Sébastien, Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique d'Evry (IG), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Plateforme Protéomique Strasbourg - Esplanade (IBMC / CNRS FRC1589 / UNIV Strasbourg), Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Moléculaire et Cellulaire [Strasbourg] (IBMC), Architecture et réactivité de l'ARN (ARN), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 647455,H2020,ERC-2014-CoG,RegulRNA(2016), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: enzymes and coenzymes (carbohydrates), viruses, [SDV]Life Sciences [q-bio], fungi, food and beverages
Abstract: The antiviral innate immune response mainly involves type I interferon (IFN) in mammalian cells. The contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the ribonuclease DICER can generate viral siRNAs in specific conditions. It has also been proposed that type I IFN and RNA silencing could be mutually exclusive antiviral responses. In order to decipher the implication of DICER during infection of human cells with the Sindbis virus, we determined its interactome by proteomics analysis. We show that DICER specifically interacts with several double-stranded RNA binding proteins and RNA helicases during viral infection. In particular, proteins such as DHX9, ADAR-1 and the protein kinase RNA-activated (PKR) are enriched with DICER in virus-infected cells. We demonstrate the importance of DICER helicase domain in its interaction with PKR and showed that it has functional consequences for the cellular response to viral infection.
Published: 2020

207. Record spintronic harvesting of thermal fluctuations using paramagnetic molecular centers

Author: Chowrira, B., Kandpal, L., Mertz, D., Kieber, C., Bahouka, A., Bernard, R., Joly, L., Monteblanco, E., Mohapatra, S., Sternitzky, E., Da Costa, V., Hehn, M., Montaigne, F., Bertrand Vileno, Choueikani, F., Ohresser, P., Lacour, D., Weber, W., Boukari, S., Bowen, M., Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), IREPA LASER (IREPA LASER), Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Lacour, Daniel, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [PHYS.COND] Physics [physics]/Condensed Matter [cond-mat], [PHYS] Physics [physics]
Abstract: Experiments and theory are reexamining how the laws of thermodynamics are expressed in a quantum world. Most quantum thermodynamics research is performed at sub-Kelvin temperatures to prevent thermal fluctuations from smearing the quantum engine's discrete energy levels that mediate the asymmetric shuffling of electrons between the electrodes. Meanwhile, several groups report that building an electron-spin based implementation by placing the discrete spin states of paramagnetic centers between ferromagnetic electrodes can not only overcome this drawback, but also induce a net electrical power output despite an apparent thermal equilibrium. We illustrate this thermodynamics conundrum through measurements on several devices of large output power, which endures beyond room temperature. We've inserted the Co paramagnetic center in Co phthalocyanine molecules between electron spin-selecting Fe/C60 interfaces within vertical molecular nanojunctions. We observe output power as high as 450nW(24nW) at 40K(360K), which leapfrogs previous results, as well as classical spintronic energy harvesting strategies involving a thermal gradient. Our data links magnetic correlations between the fluctuating paramagnetic centers and output power. This device class also behaves as a spintronically controlled switch of current flow, and of its direction. We discuss the conceptual challenges raised by these measurements. Better understanding the phenomenon and further developing this technology could help accelerate the transition to clean energy. Abstract (150 words) Several experiments have suggested that building a quantum engine using the electron spin enables the harvesting of thermal fluctuations on paramagnetic centers even though the device is at thermal equilibrium. We illustrate this thermodynamics conundrum through measurements on several devices of large output power, which endures beyond room temperature. We've inserted the Co paramagnetic center in Co phthalocyanine molecules between electron spin-selecting Fe/C60 interfaces within vertical molecular nanojunctions. We observe output power as high as 450nW(24nW) at 40K(360K), which leapfrogs previous results, as well as classical spintronic energy harvesting strategies involving a thermal gradient. Our data links magnetic correlations between the fluctuating paramagnetic centers and output power. This device class also behaves as a spintronically controlled switch of current flow, and of its direction. We discuss the
Published: 2020

208. Organic photodetectors based on supramolecular nanostructures

Author: Hanlin Wang, Yusheng Chen, Yifan Yao, Paolo Samorì, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), univOAK, Archive ouverte, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Nanostructure, Supramolecular chemistry, Photodetector, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 7. Clean energy, 01 natural sciences, law.invention, law, self‐assembly, organic crystalline, photodetector, Materials of engineering and construction. Mechanics of materials, [CHIM.MATE] Chemical Sciences/Material chemistry, supramolecular electronics, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Photodiode, phototransistor, TA401-492, Supramolecular electronics, Self-assembly, 0210 nano-technology
Abstract: Self‐assembly of semiconducting (macro)molecules enables the development of materials with tailored‐made properties which could be used as active components for optoelectronics applications. Supramolecular nanostructures combine the merits of soft matter and crystalline materials: They are flexible yet highly crystalline, and they can be processed with low‐cost solution methods. Photodetectors are devices capable to convert a light input into an electrical signal. To achieve high photoresponse, the photogenerated charge carriers should be transported efficiently through the self‐assembled nanostructures to reach the electrodes; this can be guaranteed via optimal π–electron overlapping between adjacent conjugated molecules. Moreover, because of the high surface‐to‐bulk ratio, supramolecular nanostructures are prone to enhance exciton dissociation. These qualities make supramolecular nanostructures perfect platforms for photoelectric conversion. This review highlights the most enlightening recent strategies developed for the fabrication of high‐performance photodetectors based on supramolecular nanostructures. We introduce the key figure‐of‐merit parameters and working mechanisms of organic photodetectors based on single components and p–n heterojunctions. In particular, we describe new methods to devise unprecedented planar and vertical devices to ultimately realize highly integrated and flexible photodetectors. The incorporation of ordered mesoscopic supramolecular nanostructures into macroscopic optoelectronic devices will offer great promise for the next generation of multifunctional and multiresponsive devices.
Published: 2020
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209. Noise and ergodic properties of Brownian motion in an optical tweezer: Looking at regime crossovers in an Ornstein-Uhlenbeck process

Author: Rémi Goerlich, Giovanni Manfredi, Minghao Li, Samuel Albert, Paul-Antoine Hervieux, Cyriaque Genet, univOAK, Archive ouverte, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Subjects: Physics, [PHYS.PHYS]Physics [physics]/Physics [physics], Ergodicity, Estimator, Context (language use), Ornstein–Uhlenbeck process, 01 natural sciences, Noise (electronics), 010305 fluids & plasmas, 0103 physical sciences, Ergodic theory, [PHYS.PHYS] Physics [physics]/Physics [physics], Statistical physics, Allan variance, 010306 general physics, Brownian motion
Abstract: We characterize throughout the spectral range of an optical trap the nature of the noise that drives the Brownian motion of an overdamped trapped single microsphere and its ergodicity, comparing experimental, analytical, and simulated data. We carefully analyze noise and ergodic properties (i) using the Allan variance for characterizing the noise and (ii) exploiting a test of ergodicity tailored for experiments done over finite times. We derive these two estimators in the Ornstein-Uhlenbeck low-frequency trapped-diffusion regime and study analytically their evolution toward the high-frequency Wiener-like free-diffusion regime, in very good agreement with simulated and experimental results. This study is performed comprehensively from the free-diffusion to the trapped-diffusion regimes. It also carefully looks at the specific signatures of the estimators at the crossover between the two regimes. This analysis is important to conduct when exploiting optical traps in a metrology context.
Published: 2020
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210. Probing the Growth of Organic Molecular Films Embedded between Cobalt and Iron Electrodes: Ferromagnetic Nuclear Resonance Approach

Author: Christian Meny, Jacek Arabski, Jean Weiss, Garen Avedissian, Jennifer A. Wytko, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and univOAK, Archive ouverte
Subjects: Materials science, Nanostructure, Supramolecular chemistry, Aucun, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, chemistry.chemical_compound, Molecular film, Monolayer, Electrochemistry, [CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Porphyrin, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Solid-state nuclear magnetic resonance, Ferromagnetism, chemistry, Chemical physics, 0210 nano-technology, Cobalt
Abstract: Physical properties of magnetic nanostructures and devices strongly depend on the morphological characteristics of their various components. This is especially true and becomes particularly complex in hybrid nanostructures, where soft organic molecules are at the vicinity of ferromagnetic metallic films. The supramolecular architecture of molecular films embedded between iron (Fe) and cobalt (Co) layers, has been investigated by ferromagnetic nuclear resonance (FNR). In such sample architecture, the presence of pin holes in the organic layers is detected by FNR contributions in a specific spectral range. The methodology that has been developed allows probing the continuity and packing of zinc tetra-phenyl porphyrin (ZnTPP) molecular films between the Co and Fe films. The experimental results suggest that, regardless of the nature of the ferromagnetic under-layer, at least 15 monolayers of ZnTPP are necessary to form continuous and pin-hole free molecular films. In addition, quantitative analyses show that ZnTPP layers exhibit distinct morphologies that are dependent on the nature of the ferromagnetic metallic under-layer.
Published: 2020

211. NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases

Author: Kanja, M. (Marine), Cappy, P. (Pierre), Levy, N. (Nicolas), Oladosu, O. (Oyindamola), Schmidt, S. (Sylvie), Rossolillo, P. (Paola), Winter, F. (Flore), Gasser, R. (Romain), Moog, C. (Christiane), Ruff, M. (Marc), Negroni, M. (Matteo), Lener-ory, D. (Daniela), Simon, V. (Viviana) (editor), Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV]Life Sciences [q-bio], Immunology, Mutant, Amino Acid Motifs, Computational biology, HIV Integrase, Biology, Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire, Microbiology, 03 medical and health sciences, Negative selection, Protein Domains, Virology, Cell Line, Tumor, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, C-terminus, 030302 biochemistry & molecular biology, Integrases, Amino acid, Integrase, HEK293 Cells, chemistry, Genetic Diversity and Evolution, Insect Science, biology.protein, HIV-1, Motif (music), Nuclear transport
Abstract: Using coevolution network interference based on comparison of two phylogenetically distantly related isolates, one from the main group M and the other from the minor group O of HIV-1, we identify, in the C-terminal domain (CTD) of integrase, a new functional motif constituted by four noncontiguous amino acids (N(222)K(240)N(254)K(273)). Mutating the lysines abolishes integration through decreased 3′ processing and inefficient nuclear import of reverse-transcribed genomes. Solution of the crystal structures of wild-type (wt) and mutated CTDs shows that the motif generates a positive surface potential that is important for integration. The number of charges in the motif appears more crucial than their position within the motif. Indeed, the positions of the K’s could be permutated or additional K’s could be inserted in the motif, generally without affecting integration per se. Despite this potential genetic flexibility, the NKNK arrangement is strictly conserved in natural sequences, indicative of an effective purifying selection exerted at steps other than integration. Accordingly, reverse transcription was reduced even in the mutants that retained wt integration levels, indicating that specifically the wt sequence is optimal for carrying out the multiple functions that integrase exerts. We propose that the existence of several amino acid arrangements within the motif, with comparable efficiencies of integration per se, might have constituted an asset for the acquisition of additional functions during viral evolution. IMPORTANCE Intensive studies of HIV-1 have revealed its extraordinary ability to adapt to environmental and immunological challenges, an ability that is also at the basis of antiviral treatment escape. Here, by deconvoluting the different roles of the viral integrase in the various steps of the infectious cycle, we report how the existence of alternative equally efficient structural arrangements for carrying out one function opens up the possibility of adapting to the optimization of further functionalities exerted by the same protein. Such a property provides an asset to increase the efficiency of the infectious process. On the other hand, though, the identification of this new motif provides a potential target for interfering simultaneously with multiple functions of the protein.
Published: 2020
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212. Synthesis and characterization of high molecular weight polyrotaxanes: towards the control over a wide range of threaded α-cyclodextrins

Author: Alain Lapp, Guy Schlatter, Cyril Brochon, Guillaume Bonnet, Guillaume Fleury, Georges Hadziioannou, Laboratoire d'Ingenierie des Polymères pour les Hautes Technologies, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I, and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: POLY(PROPYLENE GLYCOL), LINEAR POLYMER-CHAINS, POLY(ETHYLENE GLYCOL), INCLUSION COMPLEXES, One-pot synthesis, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, PEG ratio, Polymer chemistry, Molecule, GELS, chemistry.chemical_classification, Range (particle radiation), Cyclodextrin, Chemistry, ROTAXANES, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Characterization (materials science), [CHIM.POLY]Chemical Sciences/Polymers, 0210 nano-technology, Ethylene glycol, TRANSITION
Abstract: International audience; This work focuses on the synthesis of polyrotaxanes with high molecular weight template poly(ethylene glycol) PEG (20 kg mol(-1)) having various and well-defined amounts of alpha-cyclodextrins (alpha-CD) per chain N from 3 up to 125. N is the complexation degree of the polyrotaxane defined to be the average number of cyclodextrin molecules per template chain, The usual route has been used for high values of N, while sparsely complexed polyrotaxanes have been synthesized with an original one pot synthesis in water. Furthermore, it systernatic study wits carried out to understand and control the complexation degree N of the polyrotaxane as it function of the complexation time, the temperature and the initial ratio of alpha-CD to template polymer. It has been shown that a high temperature thermal plateau leads to the formation of very sparsely complexed (low N) pseudo-polyrotaxanes for which, the threaded alpha-CD act like nuclei and generate a favourable driving force for the final complexation at lower temperature.
Published: 2020
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213. Synthesis of Robust MOFs@COFs Porous Hybrid Materials via an Aza‐Diels–Alder Reaction: Towards High‐Performance Supercapacitor Materials

Author: Paolo Samorì, Fanny Richard, Ovidiu Ersen, Walid Baaziz, Hai-Jun Peng, Jésus Raya, Artur Ciesielski, univOAK, Archive ouverte, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse (LMSPC), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)
Subjects: Supercapacitor, [CHIM.MATE] Chemical Sciences/Material chemistry, Materials science, 010405 organic chemistry, Chimie/Matériaux, Rational design, Nanotechnology, General Chemistry, General Medicine, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, Capacitance, 7. Clean energy, 01 natural sciences, Catalysis, Cycloaddition, Energy storage, 0104 chemical sciences, Metal-organic framework, Porous medium, Hybrid material
Abstract: International audience; Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have attracted enormous attention in recent years. Recently, MOF@COF are emerging as hybrid architectures combining the unique features of the individual components to enable the generation of materials displaying novel physicochemical properties. Herein we report an unprecedented use of aza‐Diels–Alder cycloaddition reaction as post‐synthetic modification of MOF@COF‐LZU1, to generate aza‐MOFs@COFs hybrid porous materials with extended π‐delocalization. A a proof‐of‐concept, the obtained aza‐MOFs@COFs is used as electrode in supercapacitors displaying specific capacitance of 20.35 μF cm−2 and high volumetric energy density of 1.16 F cm−3. Our approach of post‐synthetic modification of MOFs@COFs hybrids implement rational design for the synthesis of functional porous materials and expands the plethora of promising application of MOFs@COFs hybrid porous materials in energy storage applications.
Published: 2020
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214. A multilevel statistical toolkit to study animal social networks: the Animal Network Toolkit Software (ANTs) R package

Author: Sosa, Sebastian, Puga-Gonzalez, Ivan, Hu, Fenghe, Pansanel, Jérôme, Xie, Xiaohua, Sueur, Cedric, Sun Yat-Sen University [Guangzhou] (SYSU), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), School of Information Science and Technology (SIST-SYsU), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: Time Factors, Ecology, Sciences du Vivant [q-bio]/Biologie animale, lcsh:R, Statistics as Topic, lcsh:Medicine, Article, Social Networking, Animals, lcsh:Q, lcsh:Science, Zoology, ComputingMilieux_MISCELLANEOUS, [CHIM.CHEM]Chemical Sciences/Cheminformatics, Software, VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480
Abstract: The possible role played by individual attributes, sociodemographic characteristics and/or ecological pressures in the interaction between animals and the development of social relationships between them is of great interest in animal ecology and evolutionary biology. Social Network Analysis is an ideal tool to study these types of questions. The Animal Network Toolkit Software (ANTs) R package was specifically developed to provide all the different social network analysis techniques currently used in the study of animal social networks. This global package enables users to (1) compute global, polyadic and nodal network measures; (2) perform data randomisation: data stream and network (node and link) permutations; (3) perform statistical permutation tests for static or temporal network analyses, and (4) visualise networks. ANTs allows researchers to perform multilevel network analyses ranging from individual network measures to interaction patterns and the analysis of the overall network structure, and carry out static or temporal network analyses without switching between different R packages, thus making a substantial contribution to advances in the study of animal behaviour. ANTs outperforms existing R packages for the computation speed of network measures and permutations.
Published: 2020
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215. High performance dyes based on triphenylamine, cinnamaldehyde and indane-1,3-dione derivatives for blue light induced polymerization for 3D printing and photocomposites

Author: Mira Abdallah, Frédéric Dumur, Bernadette Graff, Akram Hijazi, Jacques Lalevée, Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Département de Photochimie Générale (DPG), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, General Chemical Engineering, Radical polymerization, Indane, 02 engineering and technology, TMPTA, 010402 general chemistry, Photochemistry, Triphenylamine, 01 natural sciences, chemistry.chemical_compound, Dyes, Acrylate, Photoinitiator, Photopolymerization, 3D printing resin, Process Chemistry and Technology, Cationic polymerization, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Photopolymer, chemistry, Polymerization, Free Radical Polymerization, 0210 nano-technology
Abstract: In this research, high performance dyes based on triphenylamine, cinnamaldehyde and indane-1,3-dione derivatives have been designed/synthesized and evaluated as photoinitiators for visible light photopolymerization. The introduction of light-emitting diodes (LEDs) as low-cost and secured sources of irradiation is one of the major purposes in this study, where a LED at 405 nm was used for both the cationic polymerization (CP) of thin epoxide samples and the free radical polymerization (FRP) of thin TMPTA films. The proposed dyes showed very high efficiencies in the presence of the two-component photoinitiating systems based on Dye/Iodonium salt (Iod) couples or Dye/Amine (such as N-Phenylglycine (NPG) or ethyl 4-(dimethylamino)benzoate (EDB)) couples for the FRP and/or CP, highlighting their importance through a photo-oxidation (with Iod) process but also through a photo-reduction (with amine) process. The examined dyes are also able to initiate the FRP of thin acrylate films in the presence of the three-component (Dye/Iod/NPG) systems where very high rates of polymerization (Rp) and great final reactive function conversions (FCs) were achieved. A new dye (Dye 4) is proposed here for the first time (never synthesized before) and a new synthetic pathway for Dye 3 is also established. Objectives of this work concern the study of the photoinitiating abilities of the different photoinitiating systems using FTIR technique but also the study of the chemical mechanisms which was mainly examined in solution. The use of the investigated systems for 3D printing experiments (using LED projector or laser diode @405 nm) is particularly outlined. Finally, the production of thick glass fiber photocomposites presenting excellent depth of cure is also accomplished in the presence of these dyes (using near-UV conveyor: LED@395 nm).
Published: 2020
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216. Cancer Among Adolescents and Young Adults Between 2000 and 2016 in France: Incidence and Improved Survival

Author: Laetitia Daubisse-Marliac, Brigitte Lacour, Tania d'Almeida, Karima Hammas, Olivier Ganry, Alain Monnereau, Emmanuel Desandes, Nicolas Boissel, Brigitte Trétarre, Isabelle Baldi, Anne-Valérie Guizard, Anne Cowppli-Bony, Patricia Delafosse, Thomas Raze, Jacqueline Clavel, G. Coureau, Michel Velten, Sandrine Plouvier, Gautier Defossez, Xavier Troussard, Simona Bara, Véronique Bouvier, Anne-Sophie Woronoff, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Registre National des Tumeurs Solides de l'Enfant (RNTSE), Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), French network of cancer registries [Toulouse] (Francim), Registre des cancers de Loire‐Atlantique et Vendée, Imaging and Longitudinal Investigations to Ameliorate Decision-making [Nantes] (ILIAD), Site de Recherche Intégrée sur le Cancer [Nantes] (SIRIC), Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre hospitalier universitaire de Nantes (CHU Nantes), FRANCIM, Réseau des registres français du cancer, Registre des cancers de l’Isère [CHU de Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU)-Université Grenoble Alpes (UGA), CRLCC Paul Strauss, Registre des Tumeurs de l'Hérault, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Registre des tumeurs du Doubs et du Territoire de Belfort [CHRU Besançon], Pôle cancérologie (CHRU Besançon), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), CHU Amiens-Picardie, CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 (CHIMERE), Université de Picardie Jules Verne (UPJV), Registre général des cancers de Lille et de sa région (GCS-C2RC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Albert Calmette [Lille], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre Général des Tumeurs du Calvados, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des cancers de la Manche [CHPC - Site Louis Pasteur], Site Louis Pasteur [CHPC], CH Centre Hospitalier Public du Cotentin (CHPC)-CH Centre Hospitalier Public du Cotentin (CHPC), A&O (Apprentissage et Optimisation) (A&O), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Science des Données (SDD), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Algorithmes, Apprentissage et Calcul (AAC), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Université Sorbonne Paris Nord, Cancer environnement (EPICENE ), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Registre National des Hémopathies malignes de l'Enfant (RNHE), and Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Pediatrics, medicine.medical_specialty, Survival, Adolescent, Lymphoma, [SDV]Life Sciences [q-bio], Population, Improved survival, Adolescents, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Neoplasms, Medicine, Humans, 030212 general & internal medicine, Registries, Young adult, education, Melanoma, Cancer, education.field_of_study, business.industry, Incidence (epidemiology), Incidence, Cancer survival, Neoplasms, Germ Cell and Embryonal, medicine.disease, humanities, Young Adults, Survival Rate, Oncology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, France, Trends, business
Abstract: International audience; Purpose: This study was undertaken to determine cancer survival and describe the spectrum of cancers diagnosed among French adolescent and young adult (AYA) population.Methods: All cases of cancer diagnosed in 15-24 years, recorded by all French population-based registries (18% of the French population), over the 2000-2016 period, were included. Age-standardized incidences rates (ASR), conventional annual percentage change (cAPC) of incidence over time, and 5-year overall survival (5yOS) were calculated.Results: We analyzed 2,734 cancer diagnoses in adolescents and 4,199 in young adults. Overall incidence rates were 231.9/106 in 15-19 year olds and 354.0/106 in 20-24 year olds. The most frequently diagnosed cancers in male AYA were malignant gonadal germ-cell tumors (GCT), Hodgkin lymphoma (HL), and malignant melanoma, and were HL, thyroid carcinoma, and malignant melanoma in females. Cancer incidence was stable over time with a cAPC of 0.8% (p=0.72). For all cancers combined, 5yOS was 86.6% (95%CI: 85.8-87.4), greater than 85% for HL, non-Hodgkin lymphomas (NHL), GCT, thyroid carcinomas, and malignant melanomas, and around 60% and lower for osteosarcomas, Ewing tumors, hepatic carcinomas, and rhabdomyosarcomas. The 5yOS has significantly improved from 2000-2007 to 2008-2015 for all cancers pooled, with a substantial gain of 4% for 15-19 year-olds, and 3% for 20-24 year-olds.Conclusion: Notwithstanding the encouraging results for some cancers, and overall, persistent poorer survivals in AYA were shown compared to children for acute lymphoblastic leukemia, osteosarcoma, Ewing tumor, rhabdomyosarcoma and malignant hepatic tumors. These disparities require further investigation to identify and address the causes of these inferior outcomes.
Published: 2020
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217. Characterization of liver zonation‐like transcriptomic patterns in HLCs derived from hiPSCs in a microfluidic biochip environment

Author: Taketomo Kido, Eric Leclerc, Atsushi Miyajima, Benedikt Scheidecker, Stéphane Poulain, Sachi Kato, Charles Plessy, Mathieu Danoy, Myriam Lereau-Bernier, Yasuyuki Sakai, Laboratory for Integrated Micro Mechatronics Systems (LIMMS), The University of Tokyo (UTokyo)-Centre National de la Recherche Scientifique (CNRS), Centre de Ressources Biologiques - [Nancy] (CRB Nancy), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), RIKEN Center for Life Science Technologies (RIKEN CLST), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), The University of Tokyo (UTokyo), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS), Leclerc, Eric, Centre National de la Recherche Scientifique (CNRS)-The University of Tokyo (UTokyo), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
Subjects: [SDV]Life Sciences [q-bio], Cellular detoxification, Induced Pluripotent Stem Cells, SMAD, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Mesenchymal–epithelial transition, Humans, Epithelial–mesenchymal transition, Transcription factor, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Tissue Engineering, Chemistry, Wnt signaling pathway, Cell Differentiation, Microfluidic Analytical Techniques, Cell biology, Nanostructures, [SDV] Life Sciences [q-bio], Liver, 030220 oncology & carcinogenesis, Hepatocytes, Biotechnology
Abstract: The liver zonation is an important phenomenon characterized by a gradient of several functions along the liver acinus. However, this gradient remains difficult to reproduce in in-vitro conditions, making the obtention of an in-vitro method to recapitulate the liver zonation a challenging issue. In this study, we evaluated the spatial evolution of the transcriptome profile of human induced pluripotent stem cells (hiPSCs) differentiated toward hepatocytes-like cells (HLCs) phenotype in a microfluidic biochip environment. Cells collected at the inlet of the biochip, where the oxygen concentration is higher, were identified by the expression of genes involved in metabolic pathways related to cellular reorganization and cell proliferation. Cells collected in the middle and at the outlet of the biochips, where oxygen concentrations are lower, were characterized by the upregulation of genes involved in cellular detoxification processes (CYP450), PPAR signaling or arginine biosynthesis. A subset of 16 transcription factors (TFs) was extracted and identified as upstream regulators to HNF1A and PPARA. These TFs are also known as regulators to target genes engaged in the Wnt/βcatenin pathway, in the TGFβ/BMP/SMAD signaling, in the transition between epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET), in the homeostasis of lipids, bile acids and carbohydrates homeostasis, in drug metabolism, in the estrogen processing and in the oxidative stress response. Overall, the analysis allowed to confirm a partial zonation-like pattern in hiPSCs-derived HLCs in the microfluidic biochip environment. These results provide important insights into the reproduction of liver zonation in-vitro for a better understanding of the phenomenon.
Published: 2020
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218. The nature of the purine at position 34 in tRNAs of 4-codon boxes is correlated with nucleotides at positions 32 and 38 to maintain decoding fidelity

Author: Christian Rick, Johana Chicher, Renaud Geslain, Laure Schaeffer, Gilbert Eriani, Ketty Pernod, Eric Westhof, Franck Martin, Michael Ryckelynck, Eveline Hok, Laboratoire de Chimie des Systèmes Fonctionnels, Centre National de la Recherche Scientifique (CNRS), Conception et application de molécules bioactives (CAMB), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: Guanine, AcademicSubjects/SCI00010, Base Pair Mismatch, Base pair, Peptide Chain Elongation, Translational, Computational biology, Internal Ribosome Entry Sites, Ribosome, 03 medical and health sciences, Eukaryotic translation, RNA, Transfer, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, RNA and RNA-protein complexes, Anticodon, Genetics, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Codon, Cricket paralysis virus, Base Pairing, Gene Library, 030304 developmental biology, 0303 health sciences, Base Sequence, biology, Nucleotides, 030302 biochemistry & molecular biology, biology.organism_classification, 3. Good health, Internal ribosome entry site, Eukaryotic Cells, Purines, Transfer RNA, Eukaryotic Ribosome, Pseudoknot, Ribosomes
Abstract: Translation fidelity relies essentially on the ability of ribosomes to accurately recognize triplet interactions between codons on mRNAs and anticodons of tRNAs. To determine the codon-anticodon pairs that are efficiently accepted by the eukaryotic ribosome, we took advantage of the IRES from the intergenic region (IGR) of the Cricket Paralysis Virus. It contains an essential pseudoknot PKI that structurally and functionally mimics a codon-anticodon helix. We screened the entire set of 4096 possible combinations using ultrahigh-throughput screenings combining coupled transcription/translation and droplet-based microfluidics. Only 97 combinations are efficiently accepted and accommodated for translocation and further elongation: 38 combinations involve cognate recognition with Watson-Crick pairs and 59 involve near-cognate recognition pairs with at least one mismatch. More than half of the near-cognate combinations (36/59) contain a G at the first position of the anticodon (numbered 34 of tRNA). G34-containing tRNAs decoding 4-codon boxes are almost absent from eukaryotic genomes in contrast to bacterial genomes. We reconstructed these missing tRNAs and could demonstrate that these tRNAs are toxic to cells due to their miscoding capacity in eukaryotic translation systems. We also show that the nature of the purine at position 34 is correlated with the nucleotides present at 32 and 38.
Published: 2020
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219. Modifications induced by chemical skin allergens on the metabolome of reconstructed human epidermis: A pilot high‐resolution magic angle spinning nuclear magnetic resonance study

Author: Jean-Pierre Lepoittevin, Karim Elbayed, Fleur Tourneix, François-Marie Moussallieh, Eric Moss, Guillaume Lereaux, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Hrmas nmr, Magnetic Resonance Spectroscopy, Metabolite, High resolution, Pilot Projects, Dermatology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nuclear magnetic resonance, Magic angle spinning, Metabolome, Immunology and Allergy, Humans, 030212 general & internal medicine, Epidermis (botany), Discriminant Analysis, Allergens, Skin Irritancy Tests, chemistry, Dermatitis, Allergic Contact, Multivariate Analysis, Epidermis, Biomarkers
Abstract: BACKGROUND High-resolution magic angle spinning (HRMAS) is a nuclear magnetic resonance (NMR) technique that enables the characterization of metabolic phenotypes/metabolite profiles of cells, tissues, and organs, under both normal and pathological conditions, without resorting to time-consuming extraction techniques. OBJECTIVES To assess the impact of chemical skin sensitizers vs non-sensitizers on the metabolome of three-dimensional reconstructed human epidermis (RHE) by HRMAS NMR. METHODS Based on the SENS-IS assay, 12 skin sensitizers and five non-sensitizing chemicals were investigated and applied on EpiSkin RHE at the published maximal non-irritating concentrations under the conditions of the test. The metabolome of RHE samples was then analyzed by HRMAS NMR. RESULTS A total of 32 different metabolites were identified; 20 of these were quantified for all samples. Statistical univariate analysis showed that the tissue content of most measured metabolites (with the exception of acetate and glucose) was different in the untreated, treated with non-sensitizers, and treated with sensitizers samples. In RHE samples in contact with sensitizing chemicals, concentrations of 18 metabolites were significantly decreased. Alanine and tyrosine could not discriminate between sensitizer- and non-sensitizer-treated groups. A multivariate partial least-squares-discriminant analysis was performed on the two treated groups, discriminating sensitizing and non-sensitizing chemicals with a very good R2Y value of 0.87 and a good Q2Y value of 0.70. CONCLUSIONS Data suggest that HRMAS NMR could be used to monitor the impact of chemicals, skin allergens vs non-sensitizers, on the metabolome of three-dimensional RHE.
Published: 2020
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220. Peripheral Delta Opioid Receptors Mediate Formoterol Anti-allodynic Effect in a Mouse Model of Neuropathic Pain

Author: Dominique Massotte, Rhian Alice Ceredig, Unai Alduntzin, Stéphane Doridot, Michel Barrot, Pierre Hener, Eric Salvat, Florian Pierre, Ipek Yalcin, Claire Gaveriaux-Ruff, Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis Pasteur - Strasbourg I, Institut de Génétique et de Biologie Moléculaire et Cellulaire (INSERM/CNRS), INSERM/CNRS, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives, Structure des macromolécules biologiques et mécanismes de reconnaissance (SMBMR), Architecture et réactivité de l'ARN (ARN), Architecture et Réactivité de l'ARN (ARN), Centre National de la Recherche Scientifique (CNRS)-Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology, Université de Strasbourg (UNISTRA)-INSERM-Centre National de la Recherche Scientifique (CNRS), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institute of genetics and molecular and cellular biology-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Adrenergic receptor, [SDV]Life Sciences [q-bio], beta adrenergic receptor, Pharmacology, lcsh:RC321-571, δ-opioid receptor, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, medicine, peripheral nerve injury, Receptor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Original Research, beta-mimetics, business.industry, cuff model, 030104 developmental biology, Opioid, delta opioid receptor, Neuropathic pain, Peripheral nerve injury, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Formoterol, business, Free nerve ending, 030217 neurology & neurosurgery, medicine.drug, Neuroscience, mechanical allodynia
Abstract: Neuropathic pain is a challenging condition for which current therapies often remain unsatisfactory. Chronic administration of β2 adrenergic agonists, including formoterol currently used to treat asthma and chronic obstructive pulmonary disease, alleviates mechanical allodynia in the sciatic nerve cuff model of neuropathic pain. The limited clinical data currently available also suggest that formoterol would be a suitable candidate for drug repurposing. The antiallodynic action of β2 adrenergic agonists is known to require activation of the delta-opioid (DOP) receptor but better knowledge of the molecular mechanisms involved is necessary. Using a mouse line in which DOP receptors were selectively ablated in neurons expressing Nav1.8 sodium channels (DOP cKO), we showed that these DOP peripheral receptors were necessary for the antiallodynic action of the β2 adrenergic agonist formoterol in the cuff model. Using a knock-in mouse line expressing a fluorescent version of the DOP receptor fused with the enhanced green fluorescent protein (DOPeGFP), we established in a previous study, that mechanical allodynia is associated with a smaller percentage of DOPeGFP positive small peptidergic sensory neurons in dorsal root ganglia (DRG), with a reduced density of DOPeGFP positive free nerve endings in the skin and with increased DOPeGFP expression at the cell surface. Here, we showed that the density of DOPeGFP positive free nerve endings in the skin is partially restored and no increase in DOPeGFP translocation to the plasma membrane is observed in mice in which mechanical pain is alleviated upon chronic oral administration of formoterol. This study, therefore, extends our previous results by confirming that changes in the mechanical threshold are associated with changes in peripheral DOP profile. It also highlights the common impact on DOP receptors between serotonin noradrenaline reuptake inhibitors such as duloxetine and the β2 mimetic formoterol.
Published: 2020
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221. The INSIEME seismic network: a research infrastructure for studying induced seismicity in the High Agri Valley (southern Italy)

Author: Stabile, Tony, Serlenga, Vincenzo, Satriano, Claudio, Romanelli, Marco, Gueguen, Erwan, Gallipoli, Maria, Ripepi, Ermann, Saurel, Jean-Marie, Panebianco, Serena, Bellanova, Jessica, Priolo, Enrico, Stabile, Tony Alfredo, Gallipoli, Maria Rosaria, Istituto di Metodologie per l'Analisi Ambientale (IMAA), Consiglio Nazionale delle Ricerche [Potenza] (CNR), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Bureau Central de Magnétisme Terrestre (BCMT), Ecole et Observatoire des sciences de la terre (EOST), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Physique du Globe de Paris (IPGP), and Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-IPG PARIS-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: Seismometer, SURFACE, 010504 meteorology & atmospheric sciences, STREAMS, Fault (geology), Induced seismicity, 010502 geochemistry & geophysics, 01 natural sciences, NOISE, ATTENUATION, RATIO, TOMOGRAPHY, LOCATION, Seismic risk, lcsh:Environmental sciences, 0105 earth and related environmental sciences, lcsh:GE1-350, geography, geography.geographical_feature_category, business.industry, lcsh:QE1-996.5, APENNINES, lcsh:Geology, Current (stream), Seismic hazard, RESOLUTION, 13. Climate action, [SDU]Sciences of the Universe [physics], General Earth and Planetary Sciences, Data center, INJECTION, business, Geology, Seismology
Abstract: The High Agri Valley is a tectonically active area in southern Italy characterized by high seismic hazard related to fault systems capable of generating up to M=7 earthquakes (i.e. the 1857 Mw=7 Basilicata earthquake). In addition to the natural seismicity, two different clusters of induced microseismicity were recognized to be caused by industrial operations carried out in the area: (1) the water loading and unloading operations in the Pertusillo artificial reservoir and (2) the wastewater disposal at the Costa Molina 2 injection well. The twofold nature of the recorded seismicity in the High Agri Valley makes it an ideal study area to deepen the understanding of driving processes of both natural and anthropogenic earthquakes and to improve the current methodologies for the discrimination between natural and induced seismic events by collecting high-quality seismic data. Here we present the dataset gathered by the INSIEME seismic network that was installed in the High Agri Valley within the SIR-MIUR research project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation). The seismic network was planned with the aim to study the two induced seismicity clusters and to collect a full range of open-access data to be shared with the whole scientific community. The seismic network is composed of eight stations deployed in an area of 17 km×11 km around the two clusters of induced microearthquakes, and it is equipped with triaxial weak-motion broadband sensors placed at different depths down to 50 m. It allows us to detect induced microearthquakes, local and regional earthquakes, and teleseismic events from continuous data streams transmitted in real time to the CNR-IMAA Data Centre. The network has been registered at the International Federation of Digital Seismograph Networks (FDSN) with code 3F. Data collected until the end of the INSIEME project (23 March 2019) are already released with open-access policy through the FDSN web services and are available from IRIS DMC (https://doi.org/10.7914/SN/3F_2016; Stabile and INSIEME Team, 2016). Data collected after the project will be available with the permanent network code VD (https://doi.org/10.7914/SN/VD, CNR IMAA Consiglio Nazionale delle Ricerche, 2019) as part of the High Agri Valley geophysical Observatory (HAVO), a multi-parametric network managed by the CNR-IMAA research institute.
Published: 2020
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222. Multinuclear Pt II Complexes: Why Three is Better Than Two to Enhance Photophysical Properties

Author: Sourav Chakraborty, Luisa De Cola, Alessandro Aliprandi, univOAK, Archive ouverte, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Subjects: aggregation-induced emission, chemistry.chemical_element, 010402 general chemistry, Electrochemistry, Photochemistry, 01 natural sciences, Catalysis, Metal, chemistry.chemical_compound, Emission band, luminescence, multinuclear, [CHIM.COOR]Chemical Sciences/Coordination chemistry, platinum, Coordination Chemistry | Hot Paper, metallophilic interactions, Full Paper, 010405 organic chemistry, Organic Chemistry, General Chemistry, Full Papers, [CHIM.COOR] Chemical Sciences/Coordination chemistry, Blue emission, 0104 chemical sciences, 3. Good health, Monomer, chemistry, visual_art, Intramolecular force, visual_art.visual_art_medium, Luminescence, Platinum
Abstract: The self‐assembly of platinum complexes is a well‐documented process that leads to interesting changes of the photophysical and electrochemical behavior as well as to a change in reactivity of the complexes. However, it is still not clear how many metal units must interact in order to achieve the desired properties of a large assembly. This work aimed to clarify the role of the number of interacting PtII units leading to an enhancement of the spectroscopic properties and how to address inter‐ versus intramolecular processes. Therefore, a series of neutral multinuclear PtII complexes were synthesized and characterized, and their photophysical properties at different concentration were studied. Going from the monomer to dimers, the growth of a new emission band and the enhancement of the emission properties were observed. Upon increasing the platinum units up to three, the monomeric blue emission could not be detected anymore and a concentration independent bright‐yellow/orange emission, due to the establishment of intramolecular metallophilic interactions, was observed., Three is better than two: Multinuclear PtII complexes provide valuable insight into the formation of closed shell Pt⋅⋅⋅Pt metallophilic interactions and into the corresponding MMLCT excited state. Persistent aggregation‐induced emission, which is independent from the media, is observed for the trinuclear species, demonstrating that three is better than two.
Published: 2020
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223. Nonenzymatic Metabolic Reactions and Life’s Origins

Author: Joseph Moran, Kamila B. Muchowska, Sreejith J. Varma, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: Cognitive science, 010405 organic chemistry, Chemistry, Origin of Life, [CHIM.CATA] Chemical Sciences/Catalysis, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, Ribonucleotides, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Prebiotic chemistry, Metabolic pathway, Genetic Code, Abiogenesis, Carbohydrate Metabolism, Amino Acids, Sugars, Metabolic Networks and Pathways
Abstract: International audience; Prebiotic chemistry aims to explain how the biochemistry of life as we know it came to be. Most efforts in this area have focused on provisioning compounds of importance to life by multi-step synthetic routes that do not resemble biochemistry. However, gaining insight into why core metabolism uses the molecules, reactions, pathways, and overall organization that it does requires us to consider molecules not only as synthetic end goals. Equally important are the dynamic processes that build them up and break them down. This perspective has led many researchers to the hypothesis that the first stage of the origin of life began with the onset of a primitive non-enzymatic version of metabolism, initially catalyzed by naturally oc-curring minerals and metal ions. This view of life’s origins has come to be known as “metabolism first”. Continuity with modern metabolism would require a primitive version of metabolism to build and break down ketoacids, sugars, amino ac-ids, and ribonucleotides in much the same way as the pathways that do it today. This review discusses metabolic pathways of relevance to the origin of life in a manner accessible to chemists, and summarizes experiments suggesting several path-ways might have their roots in prebiotic chemistry. Finally, key remaining milestones for the protometabolic hypothesis are highlighted.
Published: 2020
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224. Large optical nonlinearity enhancement under electronic strong coupling

Author: Thomas W. Ebbesen, Kuidong Wang, Cyriaque Genet, Thibault Chervy, Kalaivanan Nagarajan, Marcus Seidel, Genet, Cyriaque, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: genetic structures, Exciton, Science, General Physics and Astronomy, FOS: Physical sciences, Physics::Optics, 02 engineering and technology, 01 natural sciences, Article, General Biochemistry, Genetics and Molecular Biology, law.invention, [PHYS] Physics [physics], chemistry.chemical_compound, law, 0103 physical sciences, Atomic and molecular physics, Cyanine, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 010306 general physics, Physics, [PHYS]Physics [physics], Multidisciplinary, business.industry, General Chemistry, 021001 nanoscience & nanotechnology, Laser, eye diseases, Nonlinear system, Optics and photonics, chemistry, Optical cavity, Optoelectronics, sense organs, Photonics, 0210 nano-technology, business, Ultrashort pulse, [PHYS.COND] Physics [physics]/Condensed Matter [cond-mat], Order of magnitude, Physics - Optics, Optics (physics.optics)
Abstract: Nonlinear optical responses provide a powerful way to understand the microscopic interactions between laser fields and matter. They are critical for plenty of applications, such as in lasers, integrated photonic circuits, biosensing and medical tools. However, most materials exhibit weak optical nonlinearities or long response times when they interact with intense optical fields. Here, we strongly couple the exciton of cyanine dye J-aggregates to an optical mode of a Fabry-Perot (FP) cavity, and achieve an enhancement of the complex nonlinear refractive index by two orders of magnitude compared with that of the uncoupled condition. Moreover, the coupled system shows an ultrafast response of ~120 fs that we extract from optical cross-correlation measurements. The ultrafast and large enhancement of the optical nonlinar coefficients in this work paves the way for exploring strong coupling effects on various third-order nonlinear optical phenomena and for technological applications., Nature Communications, 12 (1), ISSN:2041-1723
Published: 2020
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225. Preparation of hundreds of microscopic atomic ensembles in optical tweezer arrays

Author: Shannon Whitlock, S. Shevate, Manuel Morgado, G. Lochead, Y. Wang, T. M. Wintermantel, Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: Computer Networks and Communications, Atomic Physics (physics.atom-ph), Quantum simulator, FOS: Physical sciences, 01 natural sciences, Projection (linear algebra), lcsh:QA75.5-76.95, 010305 fluids & plasmas, Digital micromirror device, law.invention, Physics - Atomic Physics, law, 0103 physical sciences, Tweezers, Computer Science (miscellaneous), Physics::Atomic Physics, Quantum information, 010306 general physics, Physics, Condensed Matter::Quantum Gases, Quantum Physics, business.industry, Statistical and Nonlinear Physics, lcsh:QC1-999, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Computational Theory and Mathematics, Optical tweezers, Quantum Gases (cond-mat.quant-gas), Qubit, Optoelectronics, Atomic number, lcsh:Electronic computers. Computer science, business, Quantum Physics (quant-ph), Condensed Matter - Quantum Gases, lcsh:Physics
Abstract: We present programmable two-dimensional arrays of microscopic atomic ensembles consisting of more than 400 sites with nearly uniform filling and small atom number fluctuations. Our approach involves direct projection of light patterns from a digital micromirror device with high spatial resolution onto an optical pancake trap acting as a reservoir. This makes it possible to load large arrays of tweezers in a single step with high occupation numbers and low power requirements per tweezer. Each atomic ensemble is confined to ~1 μm3 with a controllable occupation from 20 to 200 atoms and with (sub)-Poissonian atom number fluctuations. Thus, they are ideally suited for quantum simulation and for realizing large arrays of collectively encoded Rydberg-atom qubits for quantum information processing.
Published: 2020
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226. Synthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD

Author: Jean-Luc Ferrer, Philippe Chaignon, Alain Wagner, Franck Borel, Zoljargal Baatarkhuu, Myriam Seemann, Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Strasbourg - Faculté de Médecine [Strabourg] (FMTS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)
Subjects: 0301 basic medicine, Models, Molecular, Plasmodium falciparum, lcsh:Medicine, Drug resistance, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, medicine.disease_cause, 01 natural sciences, Article, Phosphates, 03 medical and health sciences, chemistry.chemical_compound, medicine, Escherichia coli, Humans, Enzyme Inhibitors, lcsh:Science, chemistry.chemical_classification, Multidisciplinary, biology, 010405 organic chemistry, Escherichia coli Proteins, lcsh:R, Phosphate, biology.organism_classification, Antimicrobial, Drug Resistance, Multiple, 3. Good health, 0104 chemical sciences, Multiple drug resistance, Kinetics, 030104 developmental biology, Enzyme, Erythritol, chemistry, Biochemistry, Sugar Phosphates, lcsh:Q, Bacteria
Abstract: As multidrug resistant pathogenic microorganisms are a serious health menace, it is crucial to continuously develop novel medicines in order to overcome the emerging resistance. The methylerythritol phosphate pathway (MEP) is an ideal target for antimicrobial development as it is absent in humans but present in most bacteria and in the parasite Plasmodium falciparum. Here, we report the synthesis and the steady-state kinetics of a novel potent inhibitor (MEPN3) of Escherichia coli YgbP/IspD, the third enzyme of the MEP pathway. MEPN3 inhibits E. coli YgbP/IspD in mixed type mode regarding both substrates. Interestingly, MEPN3 shows the highest inhibitory activity when compared to known inhibitors of E. coli YgbP/IspD. The mechanism of this enzyme was also studied by steady-state kinetic analysis and it was found that the substrates add to the enzyme in sequential manner.
Published: 2018
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227. Connecting paths between juvenile and adult habitats in the Atlantic green turtle using genetics and satellite tracking

Author: Bénédicte Chanteur, Myriam Bouaziz, Emmanuel Sutter, Yvon Le Maho, Luc Rangon, Noémie Chanteux, Thomas Maillet, Cédric Frouin, Patrick Queneherve, Nathalie Aubert, Julie Gresser, Céline Murgale, Damien Chevallier, Cyrille Barnerias, Adrien Pinson, Jean-Pierre Allenou, Robinson Bordes, Fabien Lefebvre, Odile Petit, Christelle Guimera, Abdelwahab Benhalilou, Blandine Guillemot, Maïlis Huguin, Christelle Béranger, Fabien Vedie, Émilie Dumont-Dayot, Jordan Martin, Julien Mailles, Nicolas Lecerf, Gaëlle Hiélard, Philippine Chambault, Sidney Régis, Nicolas Cimiterra, Matthieu Duru, Denis Etienne, Benoit de Thoisy, Thierry Woignier, Laurent Thieulle, Marc Bonola, Frédéric Flora, Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Association Kwata (Kwata), Kwata, DEAL Martinique, MEDDTL, Office de l'Eau Martinique, Délégation Inter Régionale Outre-mer, Surfrider Foundation Europe, IRD Martinique-Caraïbe (IRD Martinique-Caraïbe), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Association POEMM (Association POEMM), Parc naturel régional de la Martinique (PNR Martinique), and Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU)
Subjects: migration routes, 0106 biological sciences, immature green turtle, location.country, Foraging, Endangered species, Satellite tracking, migration, 010603 evolutionary biology, 01 natural sciences, location, Juvenile, 14. Life underwater, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Ecology, Evolution, Behavior and Systematics, Original Research, Nature and Landscape Conservation, routes, Chelonia mydas, Ecology, 010604 marine biology & hydrobiology, mixed stock analysis, Exclusive economic zone, Fishery, Geography, Habitat, [SDU]Sciences of the Universe [physics], Martinique island, developmental habitats, [SDE]Environmental Sciences, Martinique
Abstract: International audience; Although it is commonly assumed that female sea turtles always return to the beach they hatched, the pathways they use during the years preceding their first reproduction and their natal origins are most often unknown, as it is the case for juvenile green turtles found in Martinique waters in the Caribbean. Given the oceanic circulation of the Guiana current flowing toward Martinique and the presence of important nesting sites for this species in Suriname and French Guiana, we may assume that a large proportion of the juvenile green turtles found in Martinique are originating from the Suriname-French Guiana beaches. To confirm this hypothesis, we performed mixed stock analysis (MSA) on 40 green turtles sampled in Martinique Island and satellite tracked 31 juvenile green turtles tagged in Martinique to (a) assess their natal origin and (b) identify their destination. Our results from MSA confirm that these juveniles are descendant from females laying on several Caribbean and Atlantic beaches, mostly from Suriname and French Guiana, but also from more southern Brazilian beaches. These results were confirmed by the tracking data as the 10 turtles leaving Martinique headed across the Caribbean-Atlantic region in six different directions and 50% of these turtles reached the Brazilian foraging grounds used by the adult green turtles coming from French Guiana. One turtle left the French Guianan coast to perform the first transatlantic migration ever recorded in juvenile green turtles, swimming toward Guinea-Bissau, which is the most important nesting site for green turtles along the African coast. The extensive movements of the migrant turtles evidenced the crossing of international waters and more than 25 exclusive economic zones, reinforcing the need for an international cooperative network to ensure the conservation of future breeders in this endangered species.
Published: 2018
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228. Impulsivity and consideration of future consequences as moderators of the association between emotional eating and body weight status

Author: Marc Bénard, France Bellisle, Fabrice Etilé, Gérard Reach, Emmanuelle Kesse-Guyot, Serge Hercberg, Sandrine Péneau, Institut de Chimie de Strasbourg, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Jourdan Sciences Economiques (PJSE), Université Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), Hotel-Dieu, Service de Diabétologie, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bénard, Marc, Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), French Ministry of Health (DGS), Sante Publique France agency, French National Institute for Health and Medical Research (INSERM), French National Institute for Agricultural Research (INRA), National Conservatory for Arts and Crafts (CNAM), Medical Research Foundation (FRM), University of Paris 13, French National Institute for Agricultural Research (Institut National de la Recherche Agronomique), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS Paris), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut National de la Recherche Agronomique (INRA), and HESAM Université (HESAM)-HESAM Université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153))
Subjects: Male, 0301 basic medicine, Emotional eating, Emotions, Medicine (miscellaneous), Weight Gain, Body Mass Index, Nutritional status, Consideration of future consequences, Impulsivity, Psychology, Cohort Studies, Eating, Surveys and Questionnaires, lcsh:RC620-627, ComputingMilieux_MISCELLANEOUS, Nutrition and Dietetics, lcsh:Public aspects of medicine, Regression analysis, Middle Aged, lcsh:Nutritional diseases. Deficiency diseases, Female, medicine.symptom, Cohort study, Adult, Physical Therapy, Sports Therapy and Rehabilitation, Clinical nutrition, 03 medical and health sciences, Barratt Impulsiveness Scale, medicine, Humans, Obesity, Life Style, Aged, 030109 nutrition & dietetics, business.industry, Research, Body Weight, Repeated measures design, lcsh:RA1-1270, Feeding Behavior, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Impulsive Behavior, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Self Report, business, Demography
Abstract: Background Emotional eating (EmE) is characterized by an over consumption of food in response to negative emotions and is associated with an increased weight status. Consideration of Future Consequences (CFC) or a low level of impulsivity could influence the association between EmE and weight status. The objective was to analyze the moderating influence of CFC and impulsivity on the relationship between EmE and BMI. Methods A total of 9974 men and 39,797 women from the NutriNet-Santé cohort study completed the revised 21-item Three-Factor Eating Questionnaire to assess their EmE, the CFC questionnaire (CFC-12) to assess their level of time perspective, and the Barratt Impulsiveness Scale (BIS-11) to assess their impulsivity. Weight and height were self-reported each year over a median follow-up of 5.3 years. The associations between EmE and repeated measures of BMI were estimated by multiple linear mixed-effects regression models stratified by gender, tertiles of the CFC, or tertiles of the BIS-11, taking into account sociodemographic and lifestyle factors. Results Overall, EmE was positively associated with BMI. CFC and impulsivity did not moderate the effect of EmE on changes of BMI per year, but quantitatively moderated the effect of EmE on overall BMI. In women, the strength of the association between EmE and weight status increased with CFC level. Difference of BMI slopes between a low and a high level of CFC was − 0.43 kg/m2 (95% CI: -0.55, − 0.30) (p
Published: 2018
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229. Peripherally Metalated Porphyrins with Applications in Catalysis, Molecular Electronics and Biomedicine

Author: Jean Weiss, Jennifer A. Wytko, Sébastien Clément, Romain Ruppert, Sébastien Richeter, Jean-François Longevial, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Incoming International Master program of IdEx (Univ. of Strasbourg), FRC-Labex CSC (ANR-10-LABX-0026 CSC), Région Languedoc-Roussillon (Research Grant 'Chercheur(se)s d’Avenir -2015–005984), ANR-14-JTIC-0002,MECANO,Ingenierie moléculaire et assemblages contrôlés de nanoobjets fonctionnels à base de porphyrines(2014), ANR-09-JCJC-0089,PORPH-NHC,Ligands ' Porphyrine-Carbène N-Hétérocyclique ' Réglables et Réactifs à des Stimuli Externes pour la Catalyse(2009), European Project: FEDER, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Porphyrins, Metal ions in aqueous solution, Biomedical Technology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Conjugated system, 010402 general chemistry, 01 natural sciences, Catalysis, Transition metal, Coordination Complexes, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, polycyclic compounds, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Electronic properties, Molecular Structure, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Chemistry, Organic Chemistry, Molecular electronics, General Chemistry, Chromophore, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, Intramolecular force, Electronics
Abstract: Porphyrins are conjugated, stable chromophores with a central core that binds a variety of metal ions and an easily functionalized peripheral framework. By combining the catalytic, electronic or cytotoxic properties of selected transition metal complexes with the binding and electronic properties of porphyrins, enhanced characteristics of the ensemble are generated. This review article focuses on porphyrins bearing one or more peripheral transition metal complexes and discusses their potential applications in catalysis or biomedicine. Modulation of the electronic properties and intramolecular communication through coordination bond linkages in bis-porphyrin scaffolds is also presented.
Published: 2018
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230. Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition

Author: Alessandra Meli, Philippe Compain, Eduardo Howard, Irene Izzo, Alberto Podjarny, Hugo Álvarez, Mathieu L. Lepage, Alexandra Cousido-Siah, Anne Bodlenner, Jérémy P. Schneider, Andre Mitschler, Laboratoire de chimie moléculaire (LCM), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Substances naturelles/chimie moléculaire, Université Louis Pasteur - Strasbourg I-Ecole européenne de chimie, polymères et matériaux [Strasbourg]-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Mannosidase, Física Atómica, Molecular y Química, Stereochemistry, Hydrolases, Ciencias Físicas, Crystal structure, Crystallography, X-Ray, X-ray diffraction, cyclic peptoids, hydrolases, iminosugars, multivalency, 010402 general chemistry, Iminosugars, 01 natural sciences, Catalysis, purl.org/becyt/ford/1 [https], Ciencias Biológicas, alpha-Mannosidase, Enzymatic hydrolysis, Catalytic Domain, Hydrolase, Glycoside hydrolase, purl.org/becyt/ford/1.6 [https], chemistry.chemical_classification, Binding Sites, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Glycosidic bond, purl.org/becyt/ford/1.3 [https], General Chemistry, Química, General Medicine, Bioquímica y Biología Molecular, Imino Sugars, Protein Structure, Tertiary, 3. Good health, 0104 chemical sciences, SYBIO, Canavalia, Zinc, chemistry, Multivalency, CIENCIAS NATURALES Y EXACTAS, Cyclic peptoids
Abstract: Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential prerequisite for successful applications is the atomic‐level understanding of how outstanding binding enhancement occurs with multivalent inhibitors. Herein we report the first high‐resolution crystal structures of the Jack bean α‐mannosidase (JBα‐man) in apo and inhibited states. The three‐dimensional structure of JBα‐man in complex with the multimeric cyclopeptoid‐based inhibitor displaying the largest binding enhancements reported so far provides decisive insight into the molecular mechanisms underlying multivalent effects in glycosidase inhibition., Instituto de Física de Líquidos y Sistemas Biológicos
Published: 2018
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231. Multivalent Metallosupramolecular Assemblies as Effective DNA Binding Agents

Author: Sébastien Ulrich, Xiao-Yu Cao, Yannick Bessin, Wojciech Drożdż, Jean-Marie Lehn, Virginie Gervais, Artur R. Stefankiewicz, Anna Walczak, Centre de Biochimie Structurale [Montpellier] (CBS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Recherche Agronomique (INRA), Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Adam Mickiewicz University in Poznań (UAM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: chemistry.chemical_element, Antineoplastic Agents, Zinc, Calorimetry, Crystallography, X-Ray, 010402 general chemistry, 01 natural sciences, Catalysis, Coordination complex, chemistry.chemical_compound, Cations, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Gel electrophoresis, 010405 organic chemistry, Organic Chemistry, Cationic polymerization, Isothermal titration calorimetry, DNA, General Chemistry, Nuclear magnetic resonance spectroscopy, Combinatorial chemistry, 0104 chemical sciences, 3. Good health, chemistry, Self-assembly
Abstract: We report the implementation of coordination chemistry onto the generation of new types of metallosupramolecular complexes with laterally appended cationic moieties for DNA binding in buffered aqueous media. Utilization of an N,N,O-type coordination pocket along with an octahedral zinc(II) metal ion allowed us to obtain mono- and tetranuclear complexes in both solution and solid state, as confirmed by NMR spectroscopy and single-crystal X-ray diffraction, respectively. By using isothermal titration calorimetry and gel electrophoresis, multiply charged cationic assemblies were observed to effectively bind to DNA through multivalent electrostatic interactions. Furthermore, we observed a correlation between the multivalency of the compounds employed and the effectiveness of DNA binding.
Published: 2018
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232. The lateral habenula interacts with the hypothalamo-pituitary adrenal axis response upon stressful cognitive demand in rats

Author: Alexandra Barbelivien, Karine Herbeaux, Victor Mathis, Brigitte Cosquer, Chantal Mathis, Dominique Sage-Ciocca, Béatrice Bothorel, Lucas Lecourtier, Vincent-Joseph Poirel, Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie et de Neurosciences Cognitives (LINC), Université Louis Pasteur - Strasbourg I-IFR37-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives (INCI), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, 0301 basic medicine, Hypothalamo-Hypophyseal System, endocrine system, Elevated plus maze, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Pituitary-Adrenal System, Water maze, 03 medical and health sciences, Behavioral Neuroscience, chemistry.chemical_compound, Cognition, 0302 clinical medicine, Corticosterone, Internal medicine, medicine, Animals, Rats, Long-Evans, Maze Learning, ComputingMilieux_MISCELLANEOUS, Spatial Memory, 6-Cyano-7-nitroquinoxaline-2,3-dione, Habenula, Thigmotaxis, business.industry, Blockade, 030104 developmental biology, Endocrinology, chemistry, CNQX, Excitatory postsynaptic potential, business, Excitatory Amino Acid Antagonists, Stress, Psychological, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery
Abstract: The lateral habenula (LHb) is involved in emotional and cognitive behaviors. Recently, we have shown in rats that blockade of excitatory inputs to the LHb not only induced deficits of memory retrieval in the water maze, but also altered swim strategies (i.e., induced excessive thigmotaxis). The latter observation, although consistent with the occurrence of memory deficits, could also possibly be the consequence of an excessive level of stress, further suggesting a role for the LHb in the stress response in our behavioral paradigm. To test this hypothesis we performed in rats intra-LHb infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 267 ng/side in 0.3 μL), or vehicle, and assessed the responsiveness of the hypothalamo-pituitary adrenal (HPA) axis to environmental stressful or non-stressful situations. We have measured plasma corticosterone (CORT) concentrations at different time points before and following intra-LHb infusion of CNQX – or of the same volume of vehicle – in three conditions: during the probe test of a water maze experiment; in an anxiety test, the elevated plus maze; and in a home cage condition. Whereas there were no differences in the home cage condition and in the elevated plus maze, in the water maze experiment we observed that CNQX-treated rats presented, along with memory deficits, a higher level of blood CORT than vehicle-treated rats. These results suggest that perturbations of the modulation of the HPA axis are consecutive to the alteration of LHb function, whether it is the result of a defective direct control of the LHb over the HPA axis, or the consequence of memory deficits.
Published: 2018
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233. Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue

Author: Vladimir Yu. Torbeev, Bruno Kieffer, Régis Boehringer, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: 0301 basic medicine, chemistry.chemical_classification, Amyloid, Protein design, Peptide, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, General Chemistry, 010402 general chemistry, 01 natural sciences, Chemical synthesis, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, chemistry, Biochemistry, Covalent bond, Molecular probe, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Function (biology)
Abstract: Discovering molecular probes that specifically recognize distinct amyloid structures is highly important for physiological studies of protein-misfolding diseases as well as for the development of diagnostic reagents and inhibitors of amyloid self-assembly. Here, we demonstrate an approach that allows for identification of N-methylated peptides that are specific binders for a particular amyloid fiber subtype (or polymorph). Protein design and chemical synthesis were used to produce covalently tethered amyloid analogues with molecular masses approaching 24 kDa and containing nine copies of an amyloidogenic peptide. Such engineered constructs served as a molecular testing platform to evaluate the aggregation properties and solubility as a function of N-methylation pattern. An advantage of the method is the possibility of biophysical characterization of amyloid constructs in solution.
Published: 2018
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234. HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

Author: Fiorini, Francesca, Robin, Jean-Philippe, Kanaan, Joanne, Borowiak, Malgorzata, Croquette, Vincent, Le Hir, Hervé, Jalinot, Pierre, Mocquet, Vincent, Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie Moléculaire de la Cellule (LBMC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Statistique de l'ENS (LPS), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre de génétique moléculaire (CGM), Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
Subjects: Human T-lymphotropic virus 1, Science, [SDV]Life Sciences [q-bio], Gene Products, tax, Article, Nonsense Mediated mRNA Decay, Protein Transport, Adenosine Triphosphate, Protein Domains, Host-Pathogen Interactions, Mutation, Trans-Activators, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, lcsh:Q, lcsh:Science, RNA Helicases, ComputingMilieux_MISCELLANEOUS, HeLa Cells
Abstract: Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax factor on UPF1 activity. Tax interacts with the central helicase core domain of UPF1 and might plug the RNA channel of UPF1, reducing its affinity for nucleic acids. Furthermore, using a single-molecule approach, we show that the sequential interaction of Tax with a RNA-bound UPF1 freezes UPF1: this latter is less sensitive to the presence of ATP and shows translocation defects, highlighting the importance of this feature for NMD. These mechanistic insights reveal how HTLV-1 hijacks the central component of NMD to ensure expression of its own genome., UPF1 is a central protein in nonsense-mediated mRNA decay (NMD), but contribution of its RNA processivity to NMD is unclear. Here, the authors show how the retroviral Tax protein interacts with and inhibits UPF1, and demonstrate that UPF1’s translocase activity contributes to NMD.
Published: 2018
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235. Binding of the RNA Chaperone Hfq on Target mRNAs Promotes the Small RNA RyhB-Induced Degradation in Escherichia coli

Author: Eric Massé, Karine Prévost, Thierry Chénard, Marie-Pier Bouchard, Carin K. Vanderpool, Marie-Pier Caron, Seongjin Park, David Lalaouna, Jingyi Fei, Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I
Subjects: Small RNA, RNase E, RNase P, QH426-470, Biology, Biochemistry, Hfq, RyhB, 03 medical and health sciences, Hfq binding site, Genetics, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, 030304 developmental biology, 0303 health sciences, Messenger RNA, Reporter gene, sRNA-induced degradation, Effector, RNA chaperone, 030302 biochemistry & molecular biology, Cell biology, Transfer RNA, small RNA (sRNA), super-resolution imaging, Function (biology)
Abstract: Many RNA-RNA interactions depend on molecular chaperones to form and remain stable in living cells. A prime example is the RNA chaperone Hfq, which is a critical effector involved in regulatory interactions between small RNAs (sRNAs) and cognate target mRNAs in Enterobacteriaceae. While there is a great deal of in vitro biochemical evidence supporting the model that Hfq enhances rates or affinities of sRNA:mRNA interactions, there is little corroborating in vivo evidence. Here we used in vivo tools including reporter genes, co-purification assays, and super-resolution microscopy to analyze the role of Hfq in RyhB-mediated regulation, and we found that Hfq is often unnecessary for efficient RyhB:mRNA complex formation in vivo. Remarkably, our data suggest that a primary function of Hfq is to promote RyhB-induced cleavage of mRNA targets by RNase E. Moreover, our work indicates that Hfq plays a more limited role in dictating regulatory outcomes following sRNAs RybB and DsrA complex formation with specific target mRNAs. Our investigation helps evaluate the roles played by Hfq in some RNA-mediated regulation.
Published: 2021
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236. Adaptation in toxic environments: comparative genomics of loci carrying antibiotic resistance genes derived from acid mine drainage waters

Author: Florence Arsène-Ploetze, Olfa Chiboub, Didier Lièvremont, Julien Farasin, Kelle C. Freel, Stephanie Fouteau, Valérie Barbe, Génétique moléculaire, génomique, microbiologie (GMGM), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Géosciences Rennes (GR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Strasbourg, Centre National de la Recherche Scientifique, ANR-12-ADAP-0013, Agence Nationale de la Recherche, Région Alsace, Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), ANR-12-ADAP-0013,THIOFILM,Rôle des biofilms dans l'adaptation et la variabilité génomique des bactéries du genre Thiomonas, impliqués dans les processus de remédiation naturelle dans les drainages miniers :(2012), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Laboratoire de Chimie Quantique, Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), univOAK, Archive ouverte, and Thiriet, Lydie
Subjects: 0301 basic medicine, Health, Toxicology and Mutagenesis, 030106 microbiology, Adaptation, Biological, Wastewater, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, complex mixtures, Mining, 03 medical and health sciences, Metals, Heavy, Databases, Genetic, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Environmental Chemistry, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Extrusion pumps, ComputingMilieux_MISCELLANEOUS, [SDV.GEN]Life Sciences [q-bio]/Genetics, Bacteria, Comparative genomics, Acid mine drainage (AMD), Drug Resistance, Microbial, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Genomics, Horizontal gene transfer, General Medicine, equipment and supplies, Pollution, Anti-Bacterial Agents, Genome evolution, 030104 developmental biology, bacteria, Acids
Abstract: International audience; Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library was previously constructed in Escherichia coli with DNA extracted from the bacterial community inhabiting an acid mine drainage (AMD) site highly contaminated with heavy metals. Here, we conducted a search for genes involved in antibiotic resistance using this previously constructed library. In particular, resistance to antibiotics was observed among five clones carrying four different loci originating from CARN5 and CARN2, two genomes reconstructed from the metagenomic data. Among the three CARN2 loci, two carry genes homologous to those previously proposed to be involved in antibiotic resistance. The third CARN2 locus carries a gene encoding a membrane transporter with an unknown function and was found to confer bacterial resistance to rifampicin, gentamycin, and kanamycin. The genome of Thiomonas delicata DSM 16361 and Thiomonas sp. X19 were sequenced in this study. Homologs of genes carried on these three CARN2 loci were found in these genomes, two of these loci were found in genomic islands. Together, these findings confirm that AMD environments contaminated with several toxic metals also constitute habitats for bacteria that function as reservoirs for antibiotic resistance genes.
Published: 2017
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237. Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes

Author: Hanna Kratzat, Jean-François Ménétret, Ottilie von Loeffelholz, S. Kundhavai Natchiar, Alexander G. Myasnikov, Isabelle Hazemann, Bruno P. Klaholz, Nadia Djabeur, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Klaholz, Bruno, and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Cryo-electron microscopy, [SDV]Life Sciences [q-bio], Cryoelectron Microscopy, Resolution (electron density), Sorting, RNA, Nanotechnology, Computational biology, Ribosomal RNA, Biology, Ribosome, [SDV] Life Sciences [q-bio], 03 medical and health sciences, 030104 developmental biology, Structural biology, RNA, Ribosomal, Structural Biology, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein biosynthesis, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Ribosomes, Molecular Biology
Abstract: International audience; Cryo electron microscopy (cryo-EM) historically has had a strong impact on the structural and mechanistic analysis of protein synthesis by the prokaryotic and eukaryotic ribosomes. Vice versa, studying ribosomes has helped moving forwards many methodological aspects in single particle cryo-EM, at the level of automated data collection and image processing including advanced techniques for particle sorting to address structural and compositional heterogeneity. Here we review some of the latest ribosome structures, where cryo-EM allowed gaining unprecedented insights based on 3D structure sorting with focused classification and refinement methods helping to reach local resolution levels better than 3Å. Such high-resolution features now enable the analysis of drug interactions with RNA and protein side-chains including even the visualization of chemical modifications of the ribosomal RNA. These advances represent a major breakthrough in structural biology and show the strong potential of cryo-EM beyond the ribosome field including for structure-based drug design.
Published: 2017
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238. Assessing transdiagnostic intrusive thoughts: Factor structure, reliability and validity of the Cognitive Intrusions Questionnaire-Transdiagnostic version in a Spanish sample

Author: Mark H. Freeston, Pablo Romero-Sanchiz, Antonio Godoy-Ávila, Aurora Gavino-Lázaro, Raquel Nogueira-Arjona, [Romero-Sanchiz, Pablo] Reg Univ Hosp Carlos Haya, Biomed Res Inst Malaga IBIMA, Mental Hlth Clin Management Unit, Plaza Hosp Civil S-N, Malaga 29009, Spain, [Romero-Sanchiz, Pablo] Univ Malaga, Sch Psychol, Personal Assessment & Psychol Treatment Dept, Blv Louis Pasteur S-N, Malaga 29010, Spain, [Nogueira-Arjona, Raquel] Univ Malaga, Sch Psychol, Personal Assessment & Psychol Treatment Dept, Blv Louis Pasteur S-N, Malaga 29010, Spain, [Godoy-Avila, Antonio] Univ Malaga, Sch Psychol, Personal Assessment & Psychol Treatment Dept, Blv Louis Pasteur S-N, Malaga 29010, Spain, [Gavino-Lazaro, Aurora] Univ Malaga, Sch Psychol, Personal Assessment & Psychol Treatment Dept, Blv Louis Pasteur S-N, Malaga 29010, Spain, [Freeston, Mark H.] Newcastle Univ, Sch Psychol, Ridley Bldg,4th Floor, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England, [Freeston, Mark H.] Newcastle Univ, Inst Neurosci, Ridley Bldg,4th Floor, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England, Spanish Ministry of Education and Science, Andalusian local government (Junta de Andalucia), and Rio Hortega Fellowship
Subjects: 050103 clinical psychology, Intrusiveness, Generalized anxiety disorder, media_common.quotation_subject, Obsession, 03 medical and health sciences, 0302 clinical medicine, Validation, medicine, Criterion validity, 0501 psychology and cognitive sciences, Obsessive-compulsive inventory, General Psychology, media_common, Transdiagnostic, Intrusion, 05 social sciences, Social anxiety, Anxiety inventory, Cognition, medicine.disease, 030227 psychiatry, Intrusive thought, Psychometric properties, Mood, Worry, Response style, Similarities, Nonclinical population, medicine.symptom, Psychology, Clinical psychology
Abstract: Intrusive thoughts are typical symptoms of anxiety-related, mood and psychotic disorders. Freeston, Ladouceur, Thibodeau, and Gagnon (1991) developed the Cognitive Intrusions Questionnaire to address the features and processing of intrusive thoughts regardless of the theoretically related disorder. This study aims to assess the psychometric properties of a revised 79-item transdiagnostic version of the Cognitive Intrusions Questionnaire (CIQ-TV). A sample of 350 Spanish undergraduate students (mean age 21.68; 78.5% female) was used to assess its factor structure, internal consistency, test-retest reliability and criterion validity. Given the range of characteristics assesses questionnaire, the psychometric properties was studied on groups of ideas based on the components of a general appraisal model (intrusiveness, appraisals, emotions and strategies).The CIQ-TV has a clear factor structure, internal consistency and test-retest reliability, except in the case of generalized anxiety disorder appraisals and thought-focused strategies. Criterion validity was good for obsessive compulsive disorder and depression appraisals and appropriate for generalized anxiety disorder and social anxiety appraisals.In summary, the results of this study showed that the CIQ-TV is a good measure for assessing intrusive thoughts and their associated processes. (C) 2017 Elsevier Ltd. All rights reserved.
Published: 2017
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239. Peptide-Protein Binding Investigated by Far-IR Spectroscopy and Molecular Dynamics Simulations

Author: yoann cote, Juan D. Ramirez, Petra Hellwig, Yves Nominé, Roland H. Stote, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre for Integrative Biology - CBI (Inserm U964 - CNRS UMR7104 - IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Science et d'ingénierie supramoléculaires (ISIS), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Chimie de la matière complexe (CMC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and univOAK, Archive ouverte
Subjects: Repressor Proteins/chemistry/genetics/*metabolism, 0301 basic medicine, Protein Structure, Secondary, Circular dichroism, Spectrophotometry, Infrared, Spectrophotometry, Cell Adhesion Molecules, Neuronal, Molecular Dynamics Simulation, PDZ domain, Biophysics, PDZ Domains, Peptide binding, Peptide, Protein Structure, Secondary, 03 medical and health sciences, Protein structure, Viral/chemistry/genetics/*metabolism, Humans, Protein secondary structure, Adaptor Proteins, Signal Transducing, Oncogene Proteins, chemistry.chemical_classification, Human papillomavirus 16, Protein Stability, Hydrogen bond, Chemistry, Circular Dichroism, C-terminus, Temperature, Water, Proteins, Hydrogen Bonding, Oncogene Proteins, Viral, Repressor Proteins, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, Crystallography, Neuronal/chemistry/genetics/*metabolism, 030104 developmental biology, Water/chemistry, Infrared, Guanylate Kinases, Cell Adhesion Molecules, Protein Binding
Abstract: PMC5479146; Molecular dynamics (MD) simulations and far-infrared (far-IR) spectroscopy were combined to study peptide binding by the second PDZ domain (PDZ1) of MAGI1, which has been identified as an important target for the Human Papilloma Virus. PDZ1 recognizes and binds to the C-terminal end of the E6 protein from high-risk Human Papilloma Virus. The far-IR spectra of two forms of the protein, an unbound APO form and a HOLO form (where the PDZ1 is bound to an 11-residue peptide derived from the C terminus of HPV16 E6), were obtained. MD simulations were used to determine the most representative structure of each form and these were used to compute their respective IR spectra by normal mode analysis. Far-UV circular dichroism spectroscopy was used to confirm the secondary structure content and the stability through temperature-dependent studies. Both the experimental and calculated far-IR spectra showed a red shift of the low-frequency peaks upon peptide binding. The calculations show that this is coincident with an increased number of hydrogen bonds formed as the peptide augments the protein beta-sheet. We further identified the contribution of surface-bound water molecules to bands in the far-IR and, through the calculations, identified potential pathways for allosteric communication. Together, these results demonstrate the utility of combining far-IR experiments and MD studies to study peptide binding by proteins.
Published: 2017
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240. Projected distributions of Southern Ocean albatrosses, petrels and fisheries as a consequence of climatic change

Author: Lucas Krüger, Jacob González-Solís, David Grémillet, Maria Virginia Petry, Ross M. Wanless, José C. Xavier, Richard A. Phillips, Vitor H. Paiva, Jaime A. Ramos, Universitat de Barcelona, Institute for System and Robotics [Lisbonne] (ISR), Universidade de Lisboa (ULISBOA), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, Southern giant petrel, Fisheries, Northern giant petrel, Tristan albatross, Albatross, Ecologia marina, 010603 evolutionary biology, 01 natural sciences, Indústria pesquera, Marine ecology, Ocells marins, biology.animal, Oceans, Canvi climàtic, 14. Life underwater, ComputingMilieux_MISCELLANEOUS, Ecology, Evolution, Behavior and Systematics, biology, Ecology, 010604 marine biology & hydrobiology, Sea birds, Climatic changes, 15. Life on land, biology.organism_classification, Climatic change, Bycatch, Fishery, Geography, 13. Climate action, [SDE]Environmental Sciences, Wandering albatross, Fisheries management, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Seabird, Canvis climàtics
Abstract: Given the major ongoing influence of environmental change on the oceans, there is a need to understand and predict the future distributions of marine species in order to plan appropriate mitigation to conserve vulnerable species and ecosystems. In this study we use tracking data from seven large seabird species of the Southern Ocean (Black-browed Albatross Thalassarche melanophris, Grey-headed Albatross T. chrysostoma, Northern Giant Petrel Macronectes halli, Southern Giant Petrel M. giganteus, Tristan Albatross Diomedea dabbenena Wandering Albatross D. exulans and White-chinned Petrel Procellaria aequinoctialis , and on fishing effort in two types of fisheries (characterised by low or high-bycatch rates), to model the associations with environmental variables (bathymetry, chlorophyll-a concentration, sea surface temperature and wind speed) through ensemble Species Distribution Models. We then project these distributions according to four climate change scenarios built by the Intergovernmental Panel for Climate Change for 2050 and 2100. The resulting projections were consistent across scenarios, indicating that there is a strong likelihood of poleward shifts in distribution of seabirds, and several range contractions (resulting from a shift in the northern, but no change in the southern limit of the range in four species). Current trends for southerly shifts in fisheries distributions are also set to continue under these climate change scenarios at least until 2100; some of these may reflect habitat loss for target species that are already over-fished. It is of particular concern that a shift in the distribution of several highly threatened seabird species would increase their overlap with fisheries where there is a high-bycatch risk. Under such scenarios, the associated shifts in distribution of seabirds and increases in bycatch risk will require much-improved fisheries management in these sensitive areas to minimise impacts on populations in decline. This article is protected by copyright. All rights reserved.
Published: 2017
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241. Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes, and Olefins from Propargylic Alcohols in HFIP

Author: Edward Richmond, Jing Yi, Pavle Kravljanac, Vuk D. Vuković, Joseph Moran, Florent Noël, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)
Subjects: General method, 010405 organic chemistry, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, 010402 general chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 01 natural sciences, 0104 chemical sciences, Lewis acid catalysis, Catalysis, Solvent, Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract: A general method to access CF3-substituted allenes from propargylic alcohols under Lewis acid catalysis in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent is described. By tuning the reaction t...
Published: 2019
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242. Integrating the VO Framework in the EOSC

Author: Molinaro, M., Allen, M., Bertocco, S., Boisson, C., Bonnarel, F., Castro Neves, M., Demlaitner, M., Genova, F., Morris, D., Schaaff, A., Taffoni, G., Voutsinas, S., California Institute of Technology (CALTECH), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (OAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), CDS, Centre de Données astronomiques de Strasbourg, Observatoire astronomique de Strasbourg, France + ESO, European Southern Observatory, Garching bei Muenchen, Allemagne, Université de Strasbourg (UNISTRA)-Université Louis Pasteur - Strasbourg I, INAF - Osservatorio Astronomico di Trieste (OAT), Istituto Nazionale di Astrofisica (INAF), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and The ADASS XXIX conference was hosted by ASTRON (Netherlands Institute for Radioastronomy) in collaboration with seven more Dutch institutes: JIVE (Joint Institute for VLBI ERIC), ALMA ARC Leiden, RuG (University of Groningen), Leiden University, SRON (Netherlands Institute for Space Research), RU (University of Nijmegen), and UvA (University of Amsterdam).
Subjects: [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU]Sciences of the Universe [physics], FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: The European Open Science Cloud (EOSC) is in its early stages, but already some aspects of the EOSC vision are starting to become reality, for example the EOSC portal and the development of metadata catalogues. In the astrophysical domain already exists an open approach to science data: the Virtual Observatory view put in place by the International Virtual Observatory Alliance (IVOA) architecture of standards. The ESCAPE (European Science Cluster of Astronomy & Particle physics ESFRI research infrastructures) project has, among its tasks, to demonstrate that the VO architecture can be integrated within the EOSC building one and to provide guidelines to ESFRI partners (European Strategy Forum on Research Infrastructures) in doing this. This contribution reports on the progress of this integration after the first months of work inside ESCAPE., 4 pages, 2 figures, ADASS XXIX proceedings
Published: 2019

243. LC-MS/MS and molecular networking

Author: Favre-Godal, Q, Gourguillon, Lorène, Valois, Ludivine, Urbain, Aurelie, Lordel-madeleine, Sonia, Choisy, P, Laboratoire d'Innovation Thérapeutique (LIT), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse BioOrganique, Département des Sciences Analytiques, Institut Pluridisciplinaire Hubert Curien (LSMBO-DSA-IPHC), Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Département Interactions Physique, Chimie et Vivant (DIPCV-IPHC), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Laboratoire de spectrométrie de masse BioOrganique, Institut Pluridisciplinaire Hubert Curien (IPHC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Published: 2019
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244. Evaluation of the stereoselectivity for titanium(IV)-based coordination entities induced by the enantiopure diphenylethene-1,2-diamine ligand

Author: Marc Henry, Laurent Barloy, Pierre Mobian, Bruno Vincent, Nathalie Kyritsakas, Emilie Macker, Alain Chaumont, Chimie de la matière complexe (CMC), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Institut Le Bel, Université Louis Pasteur - Strasbourg I, Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Départment de sciences économiques, Université de Montréal (UdeM), and Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Denticity, 010405 organic chemistry, Ligand, Diastereomer, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Inorganic Chemistry, chemistry.chemical_compound, Crystallography, Monomer, Enantiopure drug, chemistry, Diamine, Materials Chemistry, Proton NMR, Stereoselectivity, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Physical and Theoretical Chemistry
Abstract: International audience; This article describes the formation of neutral TiO 4 N 2-based coordination entities where the titanium centers are coordinated by oxygenated ligands incorporating one or two biphenolato units, i.e. L 1 and L 2 respectively. In these systems, the sixfold coordination spheres of each metallic center are completed by the enantiopure bi-dentate diphenylethene-1,2-diamine compound, abbreviated as dpeda. A solvent dependent diastereomeric ratio is evaluated by 1 H NMR for the monomeric [Ti(L 1) 2 ((1R,2R)-dpeda)] or [Ti(L 1) 2 ((1S,2S)-dpeda)] (abbreviated as [R-Ti] or [S-Ti] respectively) complexes. The highest diastereomeric ratio for [Ti(L 1) 2 (dpeda)] is obtained in chloroform (2 : 1). Energy calculation and circular dichroism spectra simulation, obtained by DFT, permit to assign the configuration of the stereoisomer formed in excess. The (1R,2R)-(+)-dpeda privileges the Δ form and (1S,2S)-(-)-dpeda the Λ form of the [Ti(L 1) 2 (dpeda)] stereoisomers. The helicates formulated as [Ti 2 (L 2) 2 ((1S,2S)-dpeda) 2 ] and [Ti 2 (L 2) 2 (1R,2R)-dpeda) 2 ] (abbreviated as [S-Ti2] or [R-Ti2] respectively) are obtained by following a multi-component self-assembly approach. In this case, the diastereomeric ratios evaluated by 1 H NMR are much lower compared to those determined for the monomeric species, and a privileged P and M configuration for the [Ti 2 (L 2) 2 (1R,2R)-dpeda) 2 ] helicate and the [Ti 2 (L 2) 2 ((1S,2S)-dpeda) 2 ] helicate respectively is assigned through theoretical calculations. Overall, this article describes a strategy to favour handedness in a helicate system where the chiral control is originated from a ligand that is not inscribed within the helical framework of the architecture.
Published: 2019
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245. Inclusive production of the $P_c$ resonances in $p \overline p $ collisions

Author: Abazov, Victor Mukhamedovich, Abbott, Braden Keim, Acharya, Bannanje Sripath, Adams, Mark Raymond, Adams, Todd, Agnew, James P., Alexeev, Guennadi D., Alkhazov, Georgiy D., Alton, Andrew K., Askew, Andrew Warren, Atkins, Scott, Augsten, Kamil, Aushev, Volodymyr, Aushev, Yegor, Avila, Carlos A., Badaud, Frederique, Bagby, Linda F., Baldin, Boris, Bandurin, Dmitry V., Banerjee, Sunanda, Barberis, Emanuela, Baringer, Philip S., Bartlett, J. Frederick, Bassler, Ursula Rita, Bazterra, Victor, Bean, Alice L., Begalli, Marcia, Bellantoni, Leo, Beri, Suman B., Bernardi, Gregorio, Bernhard, Ralf Patrick, Bertram, Iain A., Besancon, Marc, Beuselinck, Raymond, Bhat, Pushpalatha C., Bhatia, Sudeep, Bhatnagar, Vipin, Blazey, Gerald Charles, Blessing, Susan K., Bloom, Kenneth A., Boehnlein, Amber S., Boline, Daniel Dooley, Boos, Edward E., Borissov, Guennadi, Borysova, Maryna, Brandt, Andrew, Brandt, Oleg, Michelle Brochmann, Brock, Raymond L., Bross, Alan D., Brown, Duncan Paul, Bu, Xue-Bing, Buehler, Marc, Buescher, Volker, Bunichev, Viacheslav Yevgenyevich, Burdin, Sergey, Buszello, Claus Peter, Camacho-Perez, Enrique, Casey, Brendan Cameron Kieran, Castilla-Valdez, Heriberto, Caughron, Seth Aaron, Chakrabarti, Subhendu, Chan, Kwok Ming Leo, Chandra, Avdhesh, Chapon, Emilien, Chen, Guo, Cho, Sung-Woong, Choi, Suyong, Choudhary, Brajesh C., Cihangir, Selcuk, Claes, Daniel R., Clutter, Justace Randall, Cooke, Michael P., Cooper, William Edward, Corcoran, Marjorie D., Couderc, Fabrice, Cousinou, Marie-Claude, Cuth, Jakub, Cutts, David, Das, Amitabha, Davies, Gavin John, Jong, Sijbrand Jan, La Cruz-Burelo, Eduard, Deliot, Frederic, Demina, Regina, Denisov, Dmitri S., Denisov, Sergei P., Desai, Satish Vijay, Deterre, Cecile, Devaughan, Kayle Otis, Diehl, H. Thomas, Diesburg, Michael, Ding, Pengfei, Dominguez, D. Aaronm, Drutskoy, Alexey, Dubey, Abhinav Kumar, Dudko, Lev V., Duperrin, Arnaud, Dutt, Suneel, Eads, Michael T., Edmunds, Daniel L., Ellison, John A., Elvira, V. Daniel, Enari, Yuji, Evans, Harold G., Evdokimov, Anatoly V., Evdokimov, Valeri N., Faure, Alexandre, Feng, Lei, Ferbel, Thomas, Fiedler, Frank, Filthaut, Frank, Fisher, Wade Cameron, Fisk, H. Eugene, Fortner, Michael R., Fox, Harald, Franc, Jiri, Fuess, Stuart C., Garbincius, Peter H., Garcia-Bellido, Aran, Garcia-Gonzalez, Jose Andres, Gavrilov, Vladimir B., Geng, Weigang, Gerber, Cecilia Elena, Gershtein, Yuri S., Ginther, George E., Gogota, Olga, Golovanov, Georgy Anatolievich, Grannis, Paul D., Greder, Sebastien, Greenlee, Herbert B., Grenier, Gerald Jean, Gris, Phillipe Luc, Grivaz, Jean-Francois, Grohsjean, Alexander, Gruenendahl, Stefan, Gruenewald, Martin Werner, Guillemin, Thibault, Gutierrez, Gaston R., Gutierrez, Phillip, Haley, Joseph Glenn Biddle, Han, Liang, Harder, Kristian, Harel, Amnon, Hauptman, John Michael, Hays, Jonathan M., Head, Tim, Hebbeker, Thomas, Hedin, David R., Hegab, Hatim, Heinson, Ann, Heintz, Ulrich, Hensel, Carsten, Heredia-De La Cruz, Ivan, Herner, Kenneth Richard, Hesketh, Gavin G., Hildreth, Michael D., Hirosky, Robert James, Hoang, Trang, Hobbs, John D., Hoeneisen, Bruce, Hogan, Julie, Hohlfeld, Mark, Holzbauer, Jenny Lyn, Howley, Ian James, Hubacek, Zdenek, Hynek, Vlastislav, Iashvili, Ia, Ilchenko, Yuriy, Illingworth, Robert A., Ito, Albert S., Shabnam Jabeen, Jaffre, Michel J., Jayasinghe, Ayesh, Jeong, Min-Soo, Jesik, Richard L., Jiang, Peng, Johns, Kenneth Arthur, Johnson, Emily, Johnson, Marvin E., Jonckheere, Alan M., Jonsson, Per Martin, Joshi, Jyoti, Jung, Andreas Werner, Juste, Aurelio, Kajfasz, Eric, Karmanov, Dmitriy Y., Katsanos, Ioannis, Kaur, Manbir, Kehoe, Robert Leo Patrick, Kermiche, Smain, Khalatyan, Norayr, Khanov, Alexander, Kharchilava, Avto, Kharzheev, Yuri N., Kiselevich, Ivan Lvovich, Kohli, Jatinder M., Kozelov, Alexander V., Kraus, James Alexander, Kumar, Ashish, Kupco, Alexander, Kurca, Tibor, Kuzmin, Valentin Alexandrovich, Lammers, Sabine Wedam, Lebrun, Patrice, Lee, Hyeon-Seung, Lee, Seh-Wook, Lee, William M., Lei, Xiaowen, Lellouch, Jeremie, Li, Dikai, Li, Hengne, Li, Liang, Li, Qi-Zhong, Lim, Jeong Ku, Lincoln, Donald W., Linnemann, James Thomas, Lipaev, Vladimir V., Lipton, Ronald J., Liu, Huanzhao, Liu, Yanwen, Lobodenko, Alexandre, Lokajicek, Milos, Lopes Sa, Rafael, Luna-Garcia, Rene, Lyon, Adam Leonard, Maciel, Arthur K. A., Madar, Romain, Magana-Villalba, Ricardo, Malik, Sudhir, Malyshev, Vladimir L., Mansour, Jason, Martinez-Ortega, Jorge, Mccarthy, Robert L., Mcgivern, Carrie Lynne, Meijer, Melvin M., Melnitchouk, Alexander S., Menezes, Diego D., Mercadante, Pedro Galli, Merkin, Mikhail M., Meyer, Arnd, Meyer, Jorg Manfred, Miconi, Florian, Mondal, Naba K., Mulhearn, Michael James, Nagy, Elemer, Narain, Meenakshi, Nayyar, Ruchika, Neal, Homer A., Negret, Juan Pablo, Neustroev, Petr V., Nguyen, Huong Thi, Nunnemann, Thomas P., Hernandez Orduna, Jose Jesus, Osman, Nicolas Ahmed, Pal, Arnab, Parashar, Neeti, Parihar, Vivek, Park, Sung Keun, Partridge, Richard A., Parua, Nirmalya, Patwa, Abid, Penning, Bjoern, Perfilov, Maxim Anatolyevich, Peters, Reinhild Yvonne Fatima, Petridis, Konstantinos, Petrillo, Gianluca, Petroff, Pierre, Pleier, Marc-Andre, Podstavkov, Vladimir M., Popov, Alexey V., Prewitt, Michelle, Price, Darren, Prokopenko, Nikolay N., Qian, Jianming, Quadt, Arnulf, Quinn, Gene Breese, Ratoff, Peter N., Razumov, Ivan A., Ripp-Baudot, Isabelle, Rizatdinova, Flera, Rominsky, Mandy Kathleen, Ross, Anthony, Royon, Christophe, Rubinov, Paul Michael, Ruchti, Randal C., Sajot, Gerard, Sanchez-Hernandez, Alberto, Sanders, Michiel P., Santos, Angelo Souza, Savage, David G., Savitskyi, Mykola, Sawyer, H. Lee, Scanlon, Timothy P., Schamberger, R. Dean, Scheglov, Yury A., Schellman, Heidi M., Schott, Matthias, Schwanenberger, Christian, Schwienhorst, Reinhard H., Sekaric, Jadranka, Severini, Horst, Shabalina, Elizaveta K., Shary, Viacheslav V., Shaw, Savanna, Shchukin, Andrey A., Shkola, Oleg, Simak, Vladislav J., Skubic, Patrick Louis, Slattery, Paul F., Snow, Gregory R., Snow, Joel Mark, Snyder, Scott Stuart, Soldner-Rembold, Stefan, Sonnenschein, Lars, Soustruznik, Karel, Stark, Jan, Stefaniuk, Nazar, Stoyanova, Dina A., Strauss, Michael G., Suter, Louise, Svoisky, Peter V., Titov, Maxim, Tokmenin, Valeriy V., Tsai, Yun-Tse, Tsybychev, Dmitri, Tuchming, Boris, Tully, Christopher George T., Uvarov, Lev, Uvarov, Sergey L., Uzunyan, Sergey A., Kooten, Richard J., Leeuwen, Willem M., Varelas, Nikos, Varnes, Erich W., Vasilyev, Igor A., Verkheev, Alexander Yurievich, Vertogradov, Leonid S., Verzocchi, Marco, Vesterinen, Mika, Vilanova, Didier, Vokac, Petr, Wahl, Horst D., Chen Wang, Wang, Michael H. L. S., Warchol, Jadwiga, Watts, Gordon Thomas, Wayne, Mitchell R., Weichert, Jonas, Welty-Rieger, Leah Christine, Williams, Mark Richard James, Wilson, Graham Wallace, Wobisch, Markus, Wood, Darien Robert, Wyatt, Terence R., Xie, Yunhe, Yamada, Ryuji, Yang, Siqi, Yasuda, Takahiro, Yatsunenko, Yuriy A., Ye, Wanyu, Ye, Zhenyu, Yin, Hang, Yip, Kin, Youn, Sungwoo, Yu, Jiaming, Zennamo, Joseph, Zhao, Tianqi Gilbert, Zhou, Bing, Zhu, Junjie, Zielinski, Marek, Zieminska, Daria, Zivkovic, Lidija, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), D0, HEP, INSPIRE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Louis Pasteur - Strasbourg 1 (ULP), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)
Subjects: 1960 GeV-cms, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hep-ex, pentaquark: hadroproduction, pentaquark: charm, pentaquark: mass, FOS: Physical sciences, resonance: exotic, Breit-Wigner, High Energy Physics - Experiment, anti-p p: colliding beams, mass spectrum: (J/psi(3100) p), High Energy Physics - Experiment (hep-ex), pentaquark: width, mass: width, DZERO, anti-p p: scattering, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], structure, Batavia TEVATRON Coll, yield: ratio, enhancement, Particle Physics - Experiment, inclusive production, experimental results
Abstract: We present a study of the inclusive production in $p \overline p $ collisions of the pentaquark states $P_c(4440)$ and $P_c(4457)$ with the decay to the $J/\psi p$ final state previously observed by the LHCb experiment. Using a sample of candidates originating from decays of $b$-flavored hadrons, we find an enhancement in the $J/\psi p$ invariant mass distribution consistent with a sum of $P_c(4440)$ and $P_c(4457)$. The significance, with the input parameters set to the LHCb values, is $3.0\sigma$. This is the first confirmatory evidence for these pentaquark states. We measure the ratio $N_{\rm prompt}/N_{\rm nonprompt}=0.05 \pm 0.39$ and set an upper limit of 0.8 at the 95\% credibility level. The ratio of the yield of the $P_c(4312)$ to the sum of $P_c(4440)$ and $P_c(4457)$ is less than 0.6 at the 95\% credibility level. The study is based on $10.4~\rm{fb^{-1}}$ of data collected by the D0 experiment at the Fermilab Tevatron collider., Comment: 7 pages, 3 figures
Published: 2019

246. The Role of Morphology in Optically Switchable Transistors Based on a Photochromic Molecule/p‐Type Polymer Semiconductor Blend

Author: Ester Buchaca-Domingo, Karl Börjesson, Vincenzo Palermo, Alberto Salleo, Paolo Samorì, Natalie Stingelin, Duc T. Duong, Martin Herder, Marco Carroli, Andrea Liscio, Stefan Hecht, Emanuele Orgiu, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), and Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Subjects: Materials science, Photoisomerization, 02 engineering and technology, Conjugated system, 010402 general chemistry, 01 natural sciences, Biomaterials, Crystallinity, Photochromism, photoresponsive electronics, photochromic molecules, Electrochemistry, Molecule, Thin film, organic field-effect transistors, chemistry.chemical_classification, Polymer, [CHIM.MATE]Chemical Sciences/Material chemistry, poly(3-hexylthiophene), 021001 nanoscience & nanotechnology, Condensed Matter Physics, Microstructure, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, diarylethenes, chemistry, Chemical engineering, 0210 nano-technology
Abstract: International audience; The correlation between morphology and optoelectronic performance in organic thin‐film transistors based on blends of photochromic diarylethenes (DAE) and poly(3‐hexylthiophene) (P3HT) is investigated by varying molecular weight (Mw = 20–100 kDa) and regioregularity of the conjugated polymer as well as the temperature of thermal annealing (rt‐160 °C) in thin films. Semicrystalline architectures of P3HT/DAE blends comprise crystalline domains, ensuring efficient charge transport, and less aggregated regions, where DAEs are located as a result of their spontaneous expulsion from the crystalline domains during the self‐assembly. The best compromise between field‐effect mobility (µ) and switching capabilities is observed in blends containing P3HT with Mw = 50 kDa, exhibiting µ as high as 1 × 10−3 cm2 V−1 s−1 combined with a >50% photoswitching ratio. Higher or lower Mw than 50 kDa are found to be detrimental for field‐effect mobility and to lead to reduced device current switchability. The microstructure of the regioregular P3HT blend is found to be sensitive to the thermal annealing temperature, with an increase in µ and a decrease in current modulation being observed as a response to the light‐stimulus likely due to an increased P3HT‐DAE segregation, partially hindering DAE photoisomerization. The findings demonstrate the paramount importance of fine tuning the structure and morphology of bicomponent films for leveraging the multifunctional nature of optoelectronic devices.
Published: 2019
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247. Covalently linked donor–acceptor dyad for efficient single material organic solar cells

Author: Peter Baeuerle, Elena Mena Osteritz, Paolo Samorì, Tim Leydecker, Sebastian Lucas, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)
Subjects: Fullerene, Organic solar cell, 010405 organic chemistry, Ambipolar diffusion, Chemistry, Energy conversion efficiency, education, Metals and Alloys, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, 7. Clean energy, Acceptor, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Atomic orbital, Covalent bond, Materials Chemistry, Ceramics and Composites, Donor acceptor
Abstract: A novel covalently linked donor-acceptor dyad comprising a dithienopyrrol-based oligomeric donor and a fullerene acceptor was synthesized and characterized. The concomitant effect of favorable optoelectronic properties, energy levels of the frontier orbitals, and ambipolar charge transport enabled the application of the dyad in simplified solution-processed single material organic solar cells reaching a power conversion efficiency of 3.4%.
Published: 2019
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248. FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis

Author: Chantal Sellier, Nick H.M. van Bakel, Amila Zuko, Céline Sijlmans, Sina Mersmann, Anne-Laurence Boutillier, Annemarie Hübers, Amr Aly, Marina Wagner, Stéphane Dieterlé, Moushami Mallik, Marc-Antoine Goy, Clotilde Lagier-Tourenne, Gina Picchiarelli, Albert C. Ludolph, Luc Dupuis, Erik Storkebaum, Julia Higelin, Angela Rosenbohm, Li Zhang, Tobias M. Boeckers, Marije Been, Maria Demestre, Jelena Scekic-Zahirovic, Nadia Messaddeq, Inmaculada Sanjuan-Ruiz, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Laboratoire de signalisation moléculaire et neurodégénerescence, Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie, Universität Ulm - Ulm University [Ulm, Allemagne], Institut for Anatomy and Cell Biology, Laboratoire de neurosciences cognitives et adaptatives (LNCA), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Male, Muscle Fibers, Skeletal, metabolism [Neuromuscular Junction], Mice, 0302 clinical medicine, Postsynaptic potential, Receptors, Cholinergic, Gene Knock-In Techniques, Amyotrophic lateral sclerosis, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Molecular Neurobiology, metabolism [RNA-Binding Protein FUS], Mice, Knockout, Motor Neurons, physiology [RNA-Binding Protein FUS], Myogenesis, General Neuroscience, ETS transcription factor family, FUS protein, mouse, physiopathology [Amyotrophic Lateral Sclerosis], medicine.anatomical_structure, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Adult, pathology [Motor Neurons], physiology [Gene Expression Regulation], Neuromuscular Junction, Biology, pathology [Neuromuscular Junction], Neuromuscular junction, Article, 03 medical and health sciences, Young Adult, ddc:570, metabolism [Receptors, Cholinergic], medicine, Animals, Humans, pathology [Amyotrophic Lateral Sclerosis], Acetylcholine receptor, [SCCO.NEUR]Cognitive science/Neuroscience, Amyotrophic Lateral Sclerosis, Skeletal muscle, Motor neuron, physiopathology [Nerve Degeneration], medicine.disease, 030104 developmental biology, Gene Expression Regulation, Nerve Degeneration, RNA-Binding Protein FUS, pathology [Muscle Fibers, Skeletal], genetics [RNA-Binding Protein FUS], Neuroscience, 030217 neurology & neurosurgery
Abstract: Neuromuscular junction (NMJ) disruption is an early pathogenic event in amyotrophic lateral sclerosis (ALS). Yet, direct links between NMJ pathways and ALS-associated genes such as FUS, whose heterozygous mutations cause aggressive forms of ALS, remain elusive. In a knock-in Fus-ALS mouse model, we identified postsynaptic NMJ defects in newborn homozygous mutants that were attributable to mutant FUS toxicity in skeletal muscle. Adult heterozygous knock-in mice displayed smaller neuromuscular endplates that denervated before motor neuron loss, which is consistent with 'dying-back' neuronopathy. FUS was enriched in subsynaptic myonuclei, and this innervation-dependent enrichment was distorted in FUS-ALS. Mechanistically, FUS collaborates with the ETS transcription factor ERM to stimulate transcription of acetylcholine receptor genes. Co-cultures of induced pluripotent stem cell-derived motor neurons and myotubes from patients with FUS-ALS revealed endplate maturation defects due to intrinsic FUS toxicity in both motor neurons and myotubes. Thus, FUS regulates acetylcholine receptor gene expression in subsynaptic myonuclei, and muscle-intrinsic toxicity of ALS mutant FUS may contribute to dying-back motor neuronopathy.
Published: 2019
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249. Fxralpha gene is a target gene of hCG signaling pathway and represses hCG induced steroidogenesis

Author: Volle, David H, Holota, Hélène, Thirouard, Laura, Garcia, Manon, Monrose, Mélusine, de Haze, Angelique, Saru, Jean-Paul, Caira, Françoise, Beaudoin, Claude, Volle, David, Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement - Clermont Auvergne (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), VOLLE, David, ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
Subjects: Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Chorionic Gonadotropin, Biochemistry, 0302 clinical medicine, Endocrinology, Testis, Gene expression, Testosterone, Progesterone, ComputingMilieux_MISCELLANEOUS, [SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.BDD.GAM] Life Sciences [q-bio]/Development Biology/Gametogenesis, [SDV.BDLR.RS] Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, luteinizing hormone/choriogonadotropin receptor, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], Receptors, LH, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, G protein-coupled bile acid receptor, Cell biology, hCG signaling, 030220 oncology & carcinogenesis, Molecular Medicine, Gonadotropin, Signal transduction, Signal Transduction, endocrine system, Leydig, medicine.drug_class, FXRα, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Cell Line, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Animals, Endocrine system, Molecular Biology, Gene, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Cell Biology, Phosphoproteins, Mice, Inbred C57BL, 030104 developmental biology, Steroidogenesis, [SDV.BBM.MN] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], Nuclear receptor
Abstract: International audience; The bile acid receptor Farnesoid-X-Receptor alpha (FXRα), a member of the nuclear receptor superfamily, is well known for its roles in the enterohepatic tract. In addition, FXRα regulates testicular physiology through the control of both endocrine and exocrine functions. The endocrine function of the Leydig cells is mainly controlled by the hypothalamo-pituitary axis viaLH/chorionic gonadotropin (CG). If FXRα was demonstrated to control the expression of the Lhcgr gene, encoding the LH receptor; the impact of the LH/CG signaling on the Fxrα expression has not been defined so far. Here, we demonstrate that hCG increases the Fxrα gene expression through the protein kinase-A signaling pathway. Fxrα is then involved in a negative feedback of steroid synthesis. These data improve our knowledge of the local control of the testicular steroidogenesis with the identification of the link between the hypothalamo-pituitary axis and the FXRα signaling pathway.
Published: 2019
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250. Population ecology Earlier colony arrival but no trend in hatching timing in two congeneric seabirds (Uria spp.) across the North Atlantic

Author: Merkel, Benjamin, Descamps, Sébastien, Yoccoz, Nigel, Danielsen, Jóhannis, Daunt, Francis, Erikstad, Kjell, Ezhov, Aleksey, Gremillet, David, Gavrilo, Maria, Lorentsen, Svein-Håkon, Reiertsen, Tone, Steen, Harald, Systad, Geir, Lindberg Þórarinsson, Þorkell, Wanless, Sarah, Strøm, Hallvard, Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Centre for Ecology and Hydrology [Edinburgh] (CEH), Natural Environment Research Council (NERC), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: murres, timing of egg-laying, [SDE]Environmental Sciences, Uria aalge, Uria lomvia, ecology Keywords: guillemots, pre-laying period, Subject Areas: behaviour
Abstract: International audience; A global analysis recently showed that seabird breeding phenology (as the timing of egg-laying and hatching) does not, on average, respond to temperature changes or advance with time (Keogan et al. 2018 Nat. Clim. Change 8, 313-318). This group, the most threatened of all birds, is therefore prone to spatio-temporal mismatches with their food resources. Yet, other aspects of the breeding phenology may also have a marked influence on breeding success , such as the arrival date of adults at the breeding site following winter migration. Here, we used a large tracking dataset of two congeneric seabirds breeding in 14 colonies across 18°latitudes, to show that arrival date at the colony was highly variable between colonies and species (ranging 80 days) and advanced 1.4 days/year while timing of egg-laying remained unchanged, resulting in an increasing pre-laying duration between 2009 and 2018. Thus, we demonstrate that potentially not all components of seabird breeding phenology are insensitive to changing environmental conditions.
Published: 2019
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