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Recent work has demonstrated the effectiveness of gradient descent for directly recovering the factors of low-rank matrices from random linear measurements in a globally convergent manner when initialized properly. However, the performance of existing algorithms is highly sensitive in the presence of outliers that may take arbitrary values. In this paper, we propose a truncated gradient descent algorithm to improve the robustness against outliers, where the truncation is performed to rule out the contributions of samples that deviate significantly from the sample median of measurement residuals adaptively in each iteration. We demonstrate that, when initialized in a basin of attraction close to the ground truth, the proposed algorithm converges to the ground truth at a linear rate for the Gaussian measurement model with a near-optimal number of measurements, even when a constant fraction of the measurements are arbitrarily corrupted. In addition, we propose a new truncated spectral method that ensures an initialization in the basin of attraction at slightly higher requirements. We finally provide numerical experiments to validate the superior performance of the proposed approach. [ABSTRACT FROM AUTHOR]

This study aimed to develop a novel monomethoxy poly(ethylene glycol)-b-poly(D, L-lactide) (mPEG5000–PLA10 000) micelle drug delivery system to improve vinpocetine's (VP) dissolution and sustain VP concentrations in plasma. Three micelle fabrication methods were examined to maximize VP loading, followed by structurally characterization and investigation in vitro release and in vivo pharmacokinetics in Sprague-Dawley rats. The thin-film hydration is the most appropriate method of the three methods because of its high loading content. The loaded micelles exhibited a sustained release behavior up to 48 h. Following intraperitoneal administration (9 mg/kg), VP loaded micelles provided significantly higher (335%) AUC (area under concentration-time) compared to VP injection. And also increased the mean residence time [MRT(0–t)] and elimination half-life (t1/2z). There were obviously two peaks at 2 h and 9 h in VP loaded micelles concentration-time profile. In summary, these data demonstrated that poly mPEG-PLA micelles can efficiently sustain VP concentrations in plasma for 36 h, thus apprehending polymeric micelles suitability as poor aqueous solubility drug carriers. [ABSTRACT FROM AUTHOR]

The modern era is marked with users' comprehensive manners in interaction and data mining. This phenomenon is an extraordinary aspect of modern digital age. The digital path of a user associated with surfing the webpages on internet is unconditionally interconnected with a small dialogue box asking about permission to use cookies from the website. Afterwards, the relevant user's web-findings of items or information that had been browsed before is recommended automatically from the searching engine again. It is clearly acknowledged that after the announcement of the EU General Data Protection Regulation (GDPR), which was enforced in 2018, the worldwide impact has been evolving on the awareness and specification of the data protection. Therefore, data protection at the present era focusing on the area of fintech services is the research object. The objective of this study is to classify categories and definitions of users' sensitive data. Moreover, it analyses methods of defining sensitive data of the user and their realized activities especially as on-line transactions such as Zhifubao-the biggest "third-party electronic payment service platform". In the meantime, we evaluate the GDPR, compare to the Data Protection Act (DPA), and discuss whether and to what extent it marked a milestone progress above the current legislation of processing data standards, or whether some obstacles have occurred in law implementation process. [ABSTRACT FROM AUTHOR]

A new design principle for a mixed broad (TEMPO) and narrow (Trityl) line radical to boost the dynamic nuclear polarization efficiency is electron spin density matching, suggesting a polarizing agent of one Trityl tethered to at least two TEMPO moieties. [ABSTRACT FROM AUTHOR]

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin lymphoma, characterized by a variety of clinicopathological, histomorphological, immunophenotypic, and molecular genetic features. The subtype of DLBCL known as double-expressor lymphoma (DEL) is associated with an adverse prognosis when treated with R-CHOP. Our study aimed to investigate the clinicopathologic features of DEL and the prognostic roles of Myc rearrangement and C-Myc expression in DEL patients. We conducted a retrospective study of 145 patients who were identified through fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) testing. We found that DEL patients were more likely to have a non-germinal center B-cell (GCB) subtype, stage III/IV disease, and a high International Prognostic Index (IPI) score. Our survival analysis indicated that Myc rearrangement and C-Myc expression were associated with poor prognosis. Although DEL patients with Myc rearrangement exhibited trends towards worse survival compared with patients without Myc rearrangement, the differences were not statistically significant (P = 0.4008). The median overall survival (OS) of DEL patients with ≥70 % C-Myc expression (DEL-C-Mychigh) was 5 months. In the DEL-C-Mychigh group, the non-GCB subtype showed nonsignificant trends towards poorer survival compared with the GCB subtype (P = 0.1042). In conclusion, our study shows that a cut-off of ≥70 % for C-Myc expression in DEL patients can improve risk stratification, and suggests that more intensive treatment regimens may be necessary to improve survival in this high-risk population. • Patients with DEL were more likely to have a non-GCB subtype, stage III/IV disease and IPI > 2. • In the DEL group, those with ≥70 % C-Myc expression had worse OS compared with those with 40–69 % C-Myc expression. • DEL defined with a cut-off ≥70 % for C-Myc overexpression is clinically valuable. [ABSTRACT FROM AUTHOR]