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201. Interleukin-28B rs12979860 C allele: Protective against advanced fibrosis in chronic hepatitis C genotype 1 infection

Author

Kitson, MT, George, J, Dore, GJ, Leung, R, Button, P, Mccaughan, GW, Crawford, DHG, Sievert, W, Weltman, MD, Cheng, WSC, Roberts, SK, Kitson, MT, George, J, Dore, GJ, Leung, R, Button, P, Mccaughan, GW, Crawford, DHG, Sievert, W, Weltman, MD, Cheng, WSC, and Roberts, SK

Abstract

Background and Aim: While genetic polymorphisms upstream of the interleukin-28B (IL28B) gene are associated with necroinflammatory activity grade in chronic hepatitis C virus genotype 1 (HCV-1) infection, any association with fibrosis is less definitive. Pretreatment liver biopsies in a cohort of treatment-naïve patients with HCV-1 were analyzed to evaluate associations between liver histology, and the rs12979860 and rs8099917 IL28B single nucleotide polymorphisms. Methods: Two hundred sixty-six patients with HCV-1 infection and pretreatment liver biopsy were tested for the rs12979860 and rs8099917 single nucleotide polymorphisms. Predictors of advanced fibrosis (METAVIR F3/4) and high activity grade (A2/3) were identified using multivariable logistic regression analysis. Results: Forty-four patients (16.5%) had advanced fibrosis and 141 patients (53.0%) high activity grade. Prevalence of rs12979860 IL28B genotype was: CC 45.7%, CT 42.7%, and TT 11.6%. Prevalence of advanced fibrosis was lower in those with IL28B CC genotype compared with those without (11.0% vs 21.3%; P=0.03), with an increasing number of T alleles associated with a higher frequency of advanced fibrosis: CC 11.0%, CT 18.0%, TT 33.3% (P=0.01). Predictors of advanced fibrosis on multivariate analysis were platelet count (odds ratio [OR] 0.98, 95% confidence interval [CI] 0.97-0.99; P<0.0001), high activity grade (OR 5.68, 95% CI% 1.86-17.32; P=0.002), IL28B rs12979860 CC genotype (OR 0.36, 95% CI 0.14-0.93; P=0.03), and aspartate aminotransferase (OR 1.02, 95% CI 1.00-1.03; P=0.046). No association was found between rs8099917 IL28B genotype and liver histology. Conclusions: IL28B rs12979860 CC genotype appears to be independently associated with a lower prevalence of advanced fibrosis stage in HCV-1 infection. This association warrants further evaluation. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Published
2014

202. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Author

Murray, C.J.L. (Christopher), Ortblad, K.F. (Katrina F), Guinovart, C. (Caterina), Lim, S.S. (Stephen), Wolock, T.M. (Timothy M), Roberts, D.A. (D Allen), Dansereau, E.A. (Emily A), Graetz, N. (Nicholas), Barber, R.M. (Ryan), Brown, J.C. (Jonathan C), Wang, H. (Haidong), Duber, H.C. (Herbert C), Naghavi, M. (Morteza), Dicker, D. (Daniel), Dandona, L. (Lalit), Salomon, J.A. (Joshua), Heuton, K.R. (Kyle R), Foreman, K. (Kyle), Phillips, D.E. (David E), Fleming, T.D. (Thomas D), Flaxman, A.D. (Abraham D), Phillips, B.K. (Bryan K), Johnson, E.M. (Elizabeth), Coggeshall, M.S. (Megan S), Abd-Allah, F. (Foad), Abera, S.F. (Semaw Ferede), Abraham, J.P. (Jerry), Abubakar, I. (Ibrahim), Abu-Raddad, L.J. (Laith J), Abu-Rmeileh, N.M. (Niveen Me), Achoki, T. (Tom), Adeyemo, A. (Adebowale), Adou, A.K. (Arsène Kouablan), Adsuar, J.C. (José C), Agardh, E.E. (Emilie Elisabet), Akena, D. (Dickens), Al Kahbouri, M.J. (Mazin J), Alasfoor, D. (Deena), Albittar, M.I. (Mohammed I), Alcalá-Cerra, G. (Gabriel), Alegretti, M.A. (Miguel Angel), Alemu, G. (Getnet), Alfonso-Cristancho, R. (Rafael), Alhabib, S. (Samia), Ali, R. (Raghib), Alla, F. (Francois), Allen, P.J. (Peter), Alsharif, U. (Ubai), Alvarez, E. (Elena), Alvis-Guzman, N. (Nelson), Amankwaa, A.A. (Adansi A), Amare, A.T. (Azmeraw T), Amini, H. (Hassan), Ammar, K.A., Anderson, B.O. (Benjamin), Antonio, C.A.T. (Carl Abelardo T), Anwari, P. (Palwasha), Ärnlöv, J. (Johan), Arsenijevic, V.S.A. (Valentina S Arsic), Artaman, A. (Ali), Asghar, R.J. (Rana J), Assadi, R. (Reza), Atkins, L.S. (Lydia S), Badawi, A.F. (Alaa), Banerjee, A. (Amitava), Basu, S. (Saonli), Beardsley, J. (Justin), Bekele, T. (Tolesa), Bell, M.L. (Michelle Lee), Bernabe, E. (Eduardo), Beyene, T.J. (Tariku Jibat), Bhala, N. (Neeraj), Bhalla, P.L. (Pankaj), Bhutta, Z.A. (Zulfiqar A), Abdulhak, A.B. (Aref Bin), Binagwaho, A. (Agnes), Blore, J.D. (Jed D), Bose, D. (Dipan), Brainin, M. (Michael), Breitborde, N. (Nicholas), Castañeda-Orjuela, C.A. (Carlos A), Catalá-López, F. (Ferrán), Chadha, D., Chang, J.-C. (Jung-Chen), Chiang, Y.T., Chuang, T.-W. (Ting-Wu), Colomar, M. (Mercedes), Cooper Jr., L.T. (Leslie Trumbull), Cooper, C. (Charles), Courville, K.J. (Karen J), Cowie, M.R. (Martin R.), Criqui, M. (Michael), Dandona, R. (Rakhi), Dayama, A. (Anand), Leo, D. (Diego) de, Degenhardt, F., Del Pozo-Cruz, B. (Borja), Deribe, K. (Kebede), Des Jarlais, D.C. (Don C), Dessalegn, M. (Muluken), Dharmaratne, S.D. (Samath D), Dilmen, U. (Uǧur), Ding, E.L. (Eric), Driscoll, J.M., Durrani, Z., Ellenbogen, R.G. (Richard G), Ermakov, S. (Sergey), Esteghamati, A. (Alireza), Faraon, E.J.A. (Emerito Jose A), Farzadfar, F. (Farshad), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fijabi, D.O. (Daniel Obadare), Forouzanfar, M.H. (Mohammad H), Fra.Paleo, U. (Urbano), Gaffikin, L. (Lynne), Gamkrelidze, A. (Amiran), Gankpé, F.G. (Fortuné Gbètoho), Geleijnse, J.M. (Marianne), Gessner, B.D. (Bradford D), Gibney, K.B. (Katherine B), Ginawi, I.A.M. (Ibrahim Abdelmageem Mohamed), Glaser, E.L. (Elizabeth L), Gona, P. (Philimon), Goto, A. (Akimoto), Gouda, H.N. (Hebe N), Gugnani, H.C. (Harish Chander), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Hamadeh, R.R. (Randah Ribhi), Hammami, M. (Mouhanad), Hankey, G.J. (Graeme), Harb, H.L. (Hilda L), Haro, J.M. (Josep Maria), Havmoeller, R. (Rasmus), Hay, S.I. (Simon I), Hedayati, M.T. (Mohammad T), Pi, I.B.H. (Ileana B Heredia), Hoek, H.W. (Hans), Hornberger, J.C. (John C), Hosgood, H.D. (H Dean), Hotez, P.J. (Peter), Hoy, D.G. (Damian G), Huang, J. (Jian), Iburg, K.M. (Kim M), Idrisov, B.T. (Bulat T), Innos, K. (Kaire), Jacobsen, K.H. (Kathryn H), Jeemon, P. (Panniyammakal), Jensen, P.N. (Paul N), Jha, V. (Vivekanand), Jiang, G. (Guohong), Jonas, J.B., Juel, K. (Knud), Kan, H. (Haidong), Kankindi, I. (Ida), Karam, V. (Vincent), Karch, F. (Francois), Karema, C.K. (Corine Kakizi), Kaul, A. (Anil), Kawakami, N. (Norito), Kazi, D.S. (Dhruv S), Kemp, A.H. (Andrew H), Kengne, A.P. (Andre Pascal), Keren, A. (Andre), Kereselidze, M. (Maia), Khader, Y.S. (Yousef Saleh), Khalifa, S.E.A.H. (Shams Eldin Ali Hassan), Khan, E.A. (Ejaz Ahmed), Khang, Y.-H. (Young-Ho), Khonelidze, I. (Irma), Kinfu, Y. (Yohannes), Kinge, J.M. (Jonas M), Knibbs, L. (Luke), Kokubo, Y. (Yoshihiro), Kosen, S. (Soewarta), Defo, B.K. (Barthelemy Kuate), Kulkarni, V.S. (Veena S), Kulkarni, C. (Chanda), Kumar, K. (Kuldeep), Kumar, R.B. (Ravi B), Kumar, G.A. (G Anil), Kwan, G.F. (Gene F), Lai, T. (Taavi), Balaji, A.L. (Arjun Lakshmana), Lam, H. (Hilton), Lan, Q. (Qing), Lansingh, V.C. (Van C), Larson, H.J. (Heidi J), Larsson, A. (Anders), Lee, J.-T. (Jong-Tae), Leigh, P.N. (Nigel), Leinsalu, M. (Mall), Leung, R. (Ricky), Li, Y. (Yichong), Li, Y. (Yongmei), Lima, G.M.F. (Graça Maria Ferreira) de, Lin, H.-H. (Hsien-Ho), Lipshultz, S.E. (Steven), Liu, S. (Simin), Liu, Y. (Yang), Lloyd, B.K. (Belinda K), Lotufo, P.A. (Paulo A), Machado, V.M.P. (Vasco Manuel Pedro), Maclachlan, J.H. (Jennifer H), Magis-Rodriguez, C. (Carlos), Majdan, M. (Marek), Mapoma, C.C. (Christopher Chabila), Marcenes, W. (Wagner), Marzan, M.B. (Melvin Barrientos), Masci, J.R. (Joseph R), Mashal, R., Mason-Jones, A.J. (Amanda J), Mayosi, B.M. (Bongani), Mazorodze, T.T. (Tasara T), Mckay, M.J. (Michael), Meaney, M.J., Mehndiratta, M.M. (Man Mohan), Mejia-Rodriguez, F. (Fabiola), Melaku, Y.A. (Yohannes Adama), Memish, Z.A. (Ziad), Mendoza, W. (Walter), Miller, T.R. (Ted R), Mills, E.J. (Edward J), Mohammad, K.A. (Karzan Abdulmuhsin), Mokdad, A.H. (Ali H), Mola, G.L. (Glen Liddell), Monasta, L. (Lorenzo), Montico, M. (Marcella), Moore, A.R. (Ami R), Mori, R. (Riccardo), Moturi, W.N. (Wilkister Nyaora), Mukaigawara, M. (Mitsuru), Murthy, A.C. (Adeline C.), Naheed, A. (Aliya), Naidoo, K.S. (Kovin S), Naldi, L. (Lucia), Nangia, M. (Monika), Narayan, K.M.V. (Venkat), Nash, J.H.E. (John), Nejjari, C. (Chakib), Nelson, R.D. (Robert), Neupane, S.P. (Sudan Prasad), Newton, C. (Cameron), Ng, M. (Marie), Nisar, M.I. (Muhammad Imran), Nolte, S. (Sandra), Norheim, O.F. (Ole F), Nowaseb, V. (Vincent), Nyakarahuka, L. (Luke), Oh, I.-H. (In-Hwan), Ohkubo, T. (Takayoshi), Olusanya, B.O. (Bolajoko O), Omer, S.B. (Saad B), Opio, J.N. (John Nelson), Orisakwe, O.E. (Orish Ebere), Pandian, N.G. (Natesa), Papachristou, C., Caicedo, M.S. (Marco), Patten, J., Paul, V.K. (Vinod K), Pavlin, B.I. (Boris Igor), Pearce, N. (Neil), Pereira, D.M. (David M), Pervaiz, Z. (Zahid), Pesudovs, K. (Konrad), Petzold, M. (Max), Pourmalek, F. (Farshad), Qato, D. (Dima), Quezada, A.D. (Amado D), Quistberg, D.A. (D Alex), Rafay, A. (Anwar), Rahimi, K. (Kazem), Rahimi-Movaghar, V. (Vafa), Rahman, S.U. (Sajjad Ur), Raju, M. (Murugesan), Rana, S.M. (Saleem M), Razavi, H. (Homie), Reilly, R.Q. (Robert Quentin), Remuzzi, G. (Giuseppe), Richardus, J.H. (Jan Hendrik), Ronfani, L. (Luca), Roy, N. (Nadine) van, Sabin, M.L. (Miriam Lewis), Saeedi, M.Y. (Mohammad Yahya), Sahraian, M.A. (Mohammad Ali), Samonte, G.M.J. (Genesis May J), Sawhney, M.S. (Monika), Schneider, I.J.C. (Ione J C), Schwebel, D.C. (David C), Seedat, S. (Soraya), Sepanlou, S.G. (Sadaf G), Servan-Mori, E.E. (Edson E), Sheikhbahaei, S. (Sara), Shibuya, K. (Kenji), Shin, H.H. (Hwashin Hyun), Shiue, I. (Ivy), Shivakoti, R. (Rupak), Sigfusdottir, I.D. (Inga Dora), Silberberg, D.H. (Donald H), Silva, A.P. (Andrea P), Simard, J. (Jacques), Singh, J.A. (Jasvinder), Skirbekk, V. (Vegard), Sliwa, K. (Karen), Soneji, S. (Samir), Soshnikov, S.S. (Sergey S), Sreeramareddy, C.T. (Chandrashekhar T), Stathopoulou, V.K. (Vasiliki Kalliopi), Stroumpoulis, K. (Konstantinos), Swaminathan, S., Sykes, B.C. (Bryan), Tabb, K.M. (Karen M), Talongwa, R.T. (Roberto Tchio), Tenkorang, E.Y. (Eric Yeboah), Terkawi, A.S. (Abdullah Sulieman), Thomson, A.J. (Alan J), Thorne-Lyman, A.L. (Andrew L), Towbin, J.A. (Jeffrey A), Traebert, J. (Jefferson), Tran, B.X. (Bach X), Dimbuene, Z.T. (Zacharie Tsala), Tsilimbaris, M. (Miltiadis), Uchendu, U.S. (Uche S), Ukwaja, K.N. (Kingsley N), Vallely, S.R. (Stephen), Vasankari, T.J. (Tommi J), Venketasubramanian, N. (Narayanaswamy), Violante, F.S. (Francesco S), Vlassov, V.V. (Vasiliy Victorovich), Waller, P. (Patrick), Wallin, M.T. (Mitchell T), Wang, L. (Linhong), Wang, S.X., Wang, Y. (Yanping), Weichenthal, S. (Scott), Weiderpass, E. (Elisabete), Weintraub, R.G. (Robert G), Westerman, R. (Ronny), White, R.G. (Richard), Wilkinson, J.D. (James D), Williams, T.N. (Thomas Neil), Woldeyohannes, S.M. (Solomon Meseret), Wong, J.B. (John), Xu, G. (Gelin), Yang, Y.C. (Yang C), Yano, K.-I., Yip, P. (Paul), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. (Mustafa), Yu, C. (Chuanhua), Jin, K.Y. (Kim Yun), El Sayed Zaki, M. (Maysaa), Zhao, Y. (Yong), Zheng, Y. (Yuhui), Balakrishnan, K. (Kalpana), Zhou, M. (Ming), Zhu, J. (Jun), Zou, X.N. (Xiao Nong), Lopez, A.D. (Alan D), Vos, T. (Theo), Murray, C.J.L. (Christopher), Ortblad, K.F. (Katrina F), Guinovart, C. (Caterina), Lim, S.S. (Stephen), Wolock, T.M. (Timothy M), Roberts, D.A. (D Allen), Dansereau, E.A. (Emily A), Graetz, N. (Nicholas), Barber, R.M. (Ryan), Brown, J.C. (Jonathan C), Wang, H. (Haidong), Duber, H.C. (Herbert C), Naghavi, M. (Morteza), Dicker, D. (Daniel), Dandona, L. (Lalit), Salomon, J.A. (Joshua), Heuton, K.R. (Kyle R), Foreman, K. (Kyle), Phillips, D.E. (David E), Fleming, T.D. (Thomas D), Flaxman, A.D. (Abraham D), Phillips, B.K. (Bryan K), Johnson, E.M. (Elizabeth), Coggeshall, M.S. (Megan S), Abd-Allah, F. (Foad), Abera, S.F. (Semaw Ferede), Abraham, J.P. (Jerry), Abubakar, I. (Ibrahim), Abu-Raddad, L.J. (Laith J), Abu-Rmeileh, N.M. (Niveen Me), Achoki, T. (Tom), Adeyemo, A. (Adebowale), Adou, A.K. (Arsène Kouablan), Adsuar, J.C. (José C), Agardh, E.E. (Emilie Elisabet), Akena, D. (Dickens), Al Kahbouri, M.J. (Mazin J), Alasfoor, D. (Deena), Albittar, M.I. (Mohammed I), Alcalá-Cerra, G. (Gabriel), Alegretti, M.A. (Miguel Angel), Alemu, G. (Getnet), Alfonso-Cristancho, R. (Rafael), Alhabib, S. (Samia), Ali, R. (Raghib), Alla, F. (Francois), Allen, P.J. (Peter), Alsharif, U. (Ubai), Alvarez, E. (Elena), Alvis-Guzman, N. (Nelson), Amankwaa, A.A. (Adansi A), Amare, A.T. (Azmeraw T), Amini, H. (Hassan), Ammar, K.A., Anderson, B.O. (Benjamin), Antonio, C.A.T. (Carl Abelardo T), Anwari, P. (Palwasha), Ärnlöv, J. (Johan), Arsenijevic, V.S.A. (Valentina S Arsic), Artaman, A. (Ali), Asghar, R.J. (Rana J), Assadi, R. (Reza), Atkins, L.S. (Lydia S), Badawi, A.F. (Alaa), Banerjee, A. (Amitava), Basu, S. (Saonli), Beardsley, J. (Justin), Bekele, T. (Tolesa), Bell, M.L. (Michelle Lee), Bernabe, E. (Eduardo), Beyene, T.J. (Tariku Jibat), Bhala, N. (Neeraj), Bhalla, P.L. (Pankaj), Bhutta, Z.A. (Zulfiqar A), Abdulhak, A.B. (Aref Bin), Binagwaho, A. (Agnes), Blore, J.D. (Jed D), Bose, D. (Dipan), Brainin, M. (Michael), Breitborde, N. (Nicholas), Castañeda-Orjuela, C.A. (Carlos A), Catalá-López, F. (Ferrán), Chadha, D., Chang, J.-C. (Jung-Chen), Chiang, Y.T., Chuang, T.-W. (Ting-Wu), Colomar, M. (Mercedes), Cooper Jr., L.T. (Leslie Trumbull), Cooper, C. (Charles), Courville, K.J. (Karen J), Cowie, M.R. (Martin R.), Criqui, M. (Michael), Dandona, R. (Rakhi), Dayama, A. (Anand), Leo, D. (Diego) de, Degenhardt, F., Del Pozo-Cruz, B. (Borja), Deribe, K. (Kebede), Des Jarlais, D.C. (Don C), Dessalegn, M. (Muluken), Dharmaratne, S.D. (Samath D), Dilmen, U. (Uǧur), Ding, E.L. (Eric), Driscoll, J.M., Durrani, Z., Ellenbogen, R.G. (Richard G), Ermakov, S. (Sergey), Esteghamati, A. (Alireza), Faraon, E.J.A. (Emerito Jose A), Farzadfar, F. (Farshad), Fereshtehnejad, S.-M. (Seyed-Mohammad), Fijabi, D.O. (Daniel Obadare), Forouzanfar, M.H. (Mohammad H), Fra.Paleo, U. (Urbano), Gaffikin, L. (Lynne), Gamkrelidze, A. (Amiran), Gankpé, F.G. (Fortuné Gbètoho), Geleijnse, J.M. (Marianne), Gessner, B.D. (Bradford D), Gibney, K.B. (Katherine B), Ginawi, I.A.M. (Ibrahim Abdelmageem Mohamed), Glaser, E.L. (Elizabeth L), Gona, P. (Philimon), Goto, A. (Akimoto), Gouda, H.N. (Hebe N), Gugnani, H.C. (Harish Chander), Gupta, R. (Rajeev), Hafezi-Nejad, N. (Nima), Hamadeh, R.R. (Randah Ribhi), Hammami, M. (Mouhanad), Hankey, G.J. (Graeme), Harb, H.L. (Hilda L), Haro, J.M. (Josep Maria), Havmoeller, R. (Rasmus), Hay, S.I. (Simon I), Hedayati, M.T. (Mohammad T), Pi, I.B.H. (Ileana B Heredia), Hoek, H.W. (Hans), Hornberger, J.C. (John C), Hosgood, H.D. (H Dean), Hotez, P.J. (Peter), Hoy, D.G. (Damian G), Huang, J. (Jian), Iburg, K.M. (Kim M), Idrisov, B.T. (Bulat T), Innos, K. (Kaire), Jacobsen, K.H. (Kathryn H), Jeemon, P. (Panniyammakal), Jensen, P.N. (Paul N), Jha, V. (Vivekanand), Jiang, G. (Guohong), Jonas, J.B., Juel, K. (Knud), Kan, H. (Haidong), Kankindi, I. (Ida), Karam, V. (Vincent), Karch, F. (Francois), Karema, C.K. (Corine Kakizi), Kaul, A. (Anil), Kawakami, N. (Norito), Kazi, D.S. (Dhruv S), Kemp, A.H. (Andrew H), Kengne, A.P. (Andre Pascal), Keren, A. (Andre), Kereselidze, M. (Maia), Khader, Y.S. (Yousef Saleh), Khalifa, S.E.A.H. (Shams Eldin Ali Hassan), Khan, E.A. (Ejaz Ahmed), Khang, Y.-H. (Young-Ho), Khonelidze, I. (Irma), Kinfu, Y. (Yohannes), Kinge, J.M. (Jonas M), Knibbs, L. (Luke), Kokubo, Y. (Yoshihiro), Kosen, S. (Soewarta), Defo, B.K. (Barthelemy Kuate), Kulkarni, V.S. (Veena S), Kulkarni, C. (Chanda), Kumar, K. (Kuldeep), Kumar, R.B. (Ravi B), Kumar, G.A. (G Anil), Kwan, G.F. (Gene F), Lai, T. (Taavi), Balaji, A.L. (Arjun Lakshmana), Lam, H. (Hilton), Lan, Q. (Qing), Lansingh, V.C. (Van C), Larson, H.J. (Heidi J), Larsson, A. (Anders), Lee, J.-T. (Jong-Tae), Leigh, P.N. (Nigel), Leinsalu, M. (Mall), Leung, R. (Ricky), Li, Y. (Yichong), Li, Y. (Yongmei), Lima, G.M.F. (Graça Maria Ferreira) de, Lin, H.-H. (Hsien-Ho), Lipshultz, S.E. (Steven), Liu, S. (Simin), Liu, Y. (Yang), Lloyd, B.K. (Belinda K), Lotufo, P.A. (Paulo A), Machado, V.M.P. (Vasco Manuel Pedro), Maclachlan, J.H. (Jennifer H), Magis-Rodriguez, C. (Carlos), Majdan, M. (Marek), Mapoma, C.C. (Christopher Chabila), Marcenes, W. (Wagner), Marzan, M.B. (Melvin Barrientos), Masci, J.R. (Joseph R), Mashal, R., Mason-Jones, A.J. (Amanda J), Mayosi, B.M. (Bongani), Mazorodze, T.T. (Tasara T), Mckay, M.J. (Michael), Meaney, M.J., Mehndiratta, M.M. (Man Mohan), Mejia-Rodriguez, F. (Fabiola), Melaku, Y.A. (Yohannes Adama), Memish, Z.A. (Ziad), Mendoza, W. (Walter), Miller, T.R. (Ted R), Mills, E.J. (Edward J), Mohammad, K.A. (Karzan Abdulmuhsin), Mokdad, A.H. (Ali H), Mola, G.L. (Glen Liddell), Monasta, L. (Lorenzo), Montico, M. (Marcella), Moore, A.R. (Ami R), Mori, R. (Riccardo), Moturi, W.N. (Wilkister Nyaora), Mukaigawara, M. (Mitsuru), Murthy, A.C. (Adeline C.), Naheed, A. (Aliya), Naidoo, K.S. (Kovin S), Naldi, L. (Lucia), Nangia, M. (Monika), Narayan, K.M.V. (Venkat), Nash, J.H.E. (John), Nejjari, C. (Chakib), Nelson, R.D. (Robert), Neupane, S.P. (Sudan Prasad), Newton, C. (Cameron), Ng, M. (Marie), Nisar, M.I. (Muhammad Imran), Nolte, S. (Sandra), Norheim, O.F. (Ole F), Nowaseb, V. (Vincent), Nyakarahuka, L. (Luke), Oh, I.-H. (In-Hwan), Ohkubo, T. (Takayoshi), Olusanya, B.O. (Bolajoko O), Omer, S.B. (Saad B), Opio, J.N. (John Nelson), Orisakwe, O.E. (Orish Ebere), Pandian, N.G. (Natesa), Papachristou, C., Caicedo, M.S. (Marco), Patten, J., Paul, V.K. (Vinod K), Pavlin, B.I. (Boris Igor), Pearce, N. (Neil), Pereira, D.M. (David M), Pervaiz, Z. (Zahid), Pesudovs, K. (Konrad), Petzold, M. (Max), Pourmalek, F. (Farshad), Qato, D. (Dima), Quezada, A.D. (Amado D), Quistberg, D.A. (D Alex), Rafay, A. (Anwar), Rahimi, K. (Kazem), Rahimi-Movaghar, V. (Vafa), Rahman, S.U. (Sajjad Ur), Raju, M. (Murugesan), Rana, S.M. (Saleem M), Razavi, H. (Homie), Reilly, R.Q. (Robert Quentin), Remuzzi, G. (Giuseppe), Richardus, J.H. (Jan Hendrik), Ronfani, L. (Luca), Roy, N. (Nadine) van, Sabin, M.L. (Miriam Lewis), Saeedi, M.Y. (Mohammad Yahya), Sahraian, M.A. (Mohammad Ali), Samonte, G.M.J. (Genesis May J), Sawhney, M.S. (Monika), Schneider, I.J.C. (Ione J C), Schwebel, D.C. (David C), Seedat, S. (Soraya), Sepanlou, S.G. (Sadaf G), Servan-Mori, E.E. (Edson E), Sheikhbahaei, S. (Sara), Shibuya, K. (Kenji), Shin, H.H. (Hwashin Hyun), Shiue, I. (Ivy), Shivakoti, R. (Rupak), Sigfusdottir, I.D. (Inga Dora), Silberberg, D.H. (Donald H), Silva, A.P. (Andrea P), Simard, J. (Jacques), Singh, J.A. (Jasvinder), Skirbekk, V. (Vegard), Sliwa, K. (Karen), Soneji, S. (Samir), Soshnikov, S.S. (Sergey S), Sreeramareddy, C.T. (Chandrashekhar T), Stathopoulou, V.K. (Vasiliki Kalliopi), Stroumpoulis, K. (Konstantinos), Swaminathan, S., Sykes, B.C. (Bryan), Tabb, K.M. (Karen M), Talongwa, R.T. (Roberto Tchio), Tenkorang, E.Y. (Eric Yeboah), Terkawi, A.S. (Abdullah Sulieman), Thomson, A.J. (Alan J), Thorne-Lyman, A.L. (Andrew L), Towbin, J.A. (Jeffrey A), Traebert, J. (Jefferson), Tran, B.X. (Bach X), Dimbuene, Z.T. (Zacharie Tsala), Tsilimbaris, M. (Miltiadis), Uchendu, U.S. (Uche S), Ukwaja, K.N. (Kingsley N), Vallely, S.R. (Stephen), Vasankari, T.J. (Tommi J), Venketasubramanian, N. (Narayanaswamy), Violante, F.S. (Francesco S), Vlassov, V.V. (Vasiliy Victorovich), Waller, P. (Patrick), Wallin, M.T. (Mitchell T), Wang, L. (Linhong), Wang, S.X., Wang, Y. (Yanping), Weichenthal, S. (Scott), Weiderpass, E. (Elisabete), Weintraub, R.G. (Robert G), Westerman, R. (Ronny), White, R.G. (Richard), Wilkinson, J.D. (James D), Williams, T.N. (Thomas Neil), Woldeyohannes, S.M. (Solomon Meseret), Wong, J.B. (John), Xu, G. (Gelin), Yang, Y.C. (Yang C), Yano, K.-I., Yip, P. (Paul), Yonemoto, N. (Naohiro), Yoon, S.-J. (Seok-Jun), Younis, M. (Mustafa), Yu, C. (Chuanhua), Jin, K.Y. (Kim Yun), El Sayed Zaki, M. (Maysaa), Zhao, Y. (Yong), Zheng, Y. (Yuhui), Balakrishnan, K. (Kalpana), Zhou, M. (Ming), Zhu, J. (Jun), Zou, X.N. (Xiao Nong), Lopez, A.D. (Alan D), and Vos, T. (Theo)

Abstract

__Abstract__ Background: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration. Methods: To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modified based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART). For concentrated epidemics, we calibrated Spectrum models to fit vital registration data corrected for misclassification of HIV deaths. In generalised epidemics, we minimised a loss function to select epidemic curves most consistent with prevalence data and demographic data for all-cause mortality. We analysed counterfactual scenarios for HIV to assess years of life saved through prevention of mother-to-child transmission (PMTCT) and ART. For tuberculosis, we analysed vital registration and verbal autopsy data to estimate mortality using cause of death ensemble modelling. We analysed data for corrected case-notifications, expert opinions on the case-detection rate, prevalence surveys, and estimated cause-specific mortality using Bayesian meta-regression to generate consistent trends in all parameters. We analysed malaria mortality and incidence using an updated cause of death database, a systematic analysis of verbal autopsy validation studies for malaria, and recent studies (2010-13) of incidence, drug resistance, and coverage of insecticide-treated bednets. Findings: Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5). At the peak of the epidemic in 2005, HIV caused 1·7 mil

Published
2014
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205. Accommodating Special Needs Users in the Evaluation of an m-Learning Application: A Case Study

Author

Leung, R., Lumsden, Joanna, and Fritz, J.

Subjects
m-Learning, HCI, IHM, experiential learning, évaluation de prototype, apprentissage mobile, alphabétisation des adultes, apprentissage par l'expérience, adult literacy, prototype evaluation
Abstract

Adult illiteracy rates are alarmingly high worldwide. The portability, affordability, and ease of use of mobile (or handheld) devices offer a realistic opportunity to provide novel, context-sensitive literacy resources to adults with limited literacy skills. To this end, we developed the concept of ALEX - a mobile Adult Literacy support application for Experiential learning (Lumsden et al., 2005). On the basis of a medium-fidelity prototype of this application, we conducted an evaluation of ALEX using participants from our intended user group. This evaluation had two goals: (a) to assess the usefulness of the ALEX concept and the usability of its current design; and (b) to reflect on the appropriateness of our evaluation process given the literacy-related needs of our participants. This paper outlines our approach to this evaluation as well as the results we obtained and our reflections on the process., IADIS' International Conference Mobile Learning 2006, July 14-16, 2006, Dublin, Ireland

Published
2006

206. Designing a Mobile Transcriber Application for Adult Literacy Education: A Case Study

Author

Lumsden, Joanna, Leung, R., and Fritz, J.

Subjects
HCI, IHM, case study, alphabétisation, conception participative, prototypage, étude de cas, prototyping, ComputingMilieux_COMPUTERSANDEDUCATION, participatory design, m-learning, apprentissage mobile, adult literacy
Abstract

Functional illiteracy rates amongst 16 to 65 year-olds in the world's richest countries are alarmingly high. This research looks at the use of mobile technology to support experiential adult literacy education whereby adult literacy students are able to construct knowledge throughout their daily activities whilst being supported in their daily literacy challenges. This research has two primary goals: (a) to design a mobile application to support adult literacy education; and (b) to identify appropriate processes by which this design could be achieved given the nature and specific requirements of the target users. The means by which both goals were achieved, together with lessons learned, are discussed. A prototype mobile application to meet the needs of adult literacy students is also introduced., International Association for Development of theInformation Society (IADIS) International Conference Mobile Learning 2005, June 28-30, 2005, Qawra, Malta

Published
2005

211. THIRTY-YEARS OF STANDALONE PCI: EXPERIENCE FROM A HIGH VOLUME CANADIAN CENTRE

Author

Hui, W., primary, O'Brien, D.G., additional, Brass, N., additional, Cheung, P., additional, Chan, M., additional, Leung, R., additional, Tyrrell, B., additional, Bundhoo, S., additional, Pongnonthachai, P., additional, Galbraith, D., additional, Ranjbar, K., additional, Dorsch, M., additional, MacArthur, R., additional, and Klinke, P., additional

Published
2014
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217. Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma

Author

Sonabend, A. M., primary, Carminucci, A. S., additional, Amendolara, B., additional, Bansal, M., additional, Leung, R., additional, Lei, L., additional, Realubit, R., additional, Li, H., additional, Karan, C., additional, Yun, J., additional, Showers, C., additional, Rothcock, R., additional, O, J., additional, Califano, A., additional, Canoll, P., additional, and Bruce, J. N., additional

Published
2014
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219. Distortion Minimization and Continuity Preservation in Surface Pasting

Author

Leung, R. and Stephen Mann

Subjects
000 computer science
Abstract

Proceedings of Graphics Interface 2003, Halifax, Nova Scotia, Canada, Canada, 11 - 13 June 2003, 193-200, We introduce the Camera Aware View-dEpendent Continuous Level Of Detail (CAVECLOD) polygon mesh representation. Several techniques recently have been developed that use a hierarchy of vertex split and merge operations to achieve continuous LOD. These techniques exploit temporal coherence. However, when multiple cameras are simultaneously viewing a polygon mesh at continuous LOD, the exploitation of temporal coherence is difficult. The CAVECLOD mesh representation enables multiple cameras to simultaneously exploit temporal coherence. Texture coordinates and normal vectors are preserved and the algorithm uses Microsoft DirectX Vertex Buffers and Index Buffers for efficient rendering. Interactive frame rates are achieved on large models on commercially available hardware.

Published
2003
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220. Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

Author

Huckins, L M, Hatzikotoulas, K, Southam, L, Thornton, L M, Steinberg, J, Aguilera-McKay, F, Treasure, J, Schmidt, U, Gunasinghe, C, Romero, A, Curtis, C, Rhodes, D, Moens, J, Kalsi, G, Dempster, D, Leung, R, Keohane, A, Burghardt, R, Ehrlich, S, Hebebrand, J, Hinney, A, Ludolph, A, Walton, E, Deloukas, P, Hofman, A, Palotie, A, Palta, P, van Rooij, F J A, Stirrups, K, Adan, R, Boni, C, Cone, R, Dedoussis, G, van Furth, E, Gonidakis, F, Gorwood, P, Hudson, J, Kaprio, J, Kas, M, Keski-Rahonen, A, Kiezebrink, K, Knudsen, G-P, Slof-Op 't Landt, M C T, Maj, M, Monteleone, A M, Monteleone, P, Raevuori, A H, Reichborn-Kjennerud, T, Tozzi, F, Tsitsika, A, van Elburg, A, Collier, D A, Sullivan, P F, Breen, G, Bulik, C M, and Zeggini, E

Abstract

Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.

Published
2018
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223. CELL BIOLOGY AND SIGNALING

Author

Agarwal, M., primary, Nitta, R., additional, Dovat, S., additional, Li, G., additional, Arita, H., additional, Narita, Y., additional, Fukushima, S., additional, Tateishi, K., additional, Matsushita, Y., additional, Yoshida, A., additional, Miyakita, Y., additional, Ohno, M., additional, Collins, V. P., additional, Kawahara, N., additional, Shibui, S., additional, Ichimura, K., additional, Kahn, S. A., additional, Gholamin, S., additional, Junier, M.-P., additional, Chneiweiss, H., additional, Weissman, I., additional, Mitra, S., additional, Cheshier, S., additional, Avril, T., additional, Hamlat, A., additional, Le Reste, P.-J., additional, Mosser, J., additional, Quillien, V., additional, Carrato, C., additional, Munoz-Marmol, A., additional, Serrano, L., additional, Pijuan, L., additional, Hostalot, C., additional, Villa, S. l., additional, Ariza, A., additional, Etxaniz, O., additional, Balana, C., additional, Benveniste, E. T., additional, Zheng, Y., additional, McFarland, B., additional, Drygin, D., additional, Bellis, S., additional, Bredel, M., additional, Lotsch, D., additional, Engelmaier, C., additional, Allerstorfer, S., additional, Grusch, M., additional, Pichler, J., additional, Weis, S., additional, Hainfellner, J., additional, Marosi, C., additional, Spiegl-Kreinecker, S., additional, Berger, W., additional, Bronisz, A., additional, Nowicki, M. O., additional, Wang, Y., additional, Ansari, K., additional, Chiocca, E. A., additional, Godlewski, J., additional, Brown, K., additional, Kwatra, M., additional, Bui, T., additional, Zhu, S., additional, Kozono, D., additional, Li, J., additional, Kushwaha, D., additional, Carter, B., additional, Chen, C., additional, Schulte, J., additional, Srikanth, M., additional, Das, S., additional, Zhang, J., additional, Lathia, J., additional, Yin, L., additional, Rich, J., additional, Olson, E., additional, Kessler, J., additional, Chenn, A., additional, Cherry, A., additional, Haas, B., additional, Lin, Y. H., additional, Ong, S.-E., additional, Stella, N., additional, Cifarelli, C. P., additional, Griffin, R. J., additional, Cong, D., additional, Zhu, W., additional, Shi, Y., additional, Clark, P., additional, Kuo, J., additional, Hu, S., additional, Sun, D., additional, Bookland, M., additional, Darbinian, N., additional, Dey, A., additional, Robitaille, M., additional, Remke, M., additional, Faury, D., additional, Maier, C., additional, Malhotra, A., additional, Jabado, N., additional, Taylor, M., additional, Angers, S., additional, Kenney, A., additional, Ren, X., additional, Zhou, H., additional, Schur, M., additional, Baweja, A., additional, Singh, M., additional, Erdreich-Epstein, A., additional, Fu, J., additional, Koul, D., additional, Yao, J., additional, Saito, N., additional, Zheng, S., additional, Verhaak, R., additional, Lu, Z., additional, Yung, W. K. A., additional, Gomez, G., additional, Volinia, S., additional, Croce, C., additional, Brennan, C., additional, Cavenee, W., additional, Furnari, F., additional, Lopez, S. G., additional, Qu, D., additional, Petritsch, C., additional, Gonzalez-Huarriz, M., additional, Aldave, G., additional, Ravi, D., additional, Rubio, A., additional, Diez-Valle, R., additional, Marigil, M., additional, Jauregi, P., additional, Vera, B., additional, Rocha, A. A. d. l., additional, Tejada-Solis, S., additional, Alonso, M. M., additional, Gopal, U., additional, Isaacs, J., additional, Gruber-Olipitz, M., additional, Dabral, S., additional, Ramkissoon, S., additional, Kung, A., additional, Pak, E., additional, Chung, J., additional, Theisen, M., additional, Sun, Y., additional, Monrose, V., additional, Franchetti, Y., additional, Shulman, D., additional, Redjal, N., additional, Tabak, B., additional, Beroukhim, R., additional, Zhao, J., additional, Buonamici, S., additional, Ligon, K., additional, Kelleher, J., additional, Segal, R., additional, Canton, D., additional, Diaz, P., additional, Scott, J., additional, Hara, K., additional, Kageji, T., additional, Mizobuchi, Y., additional, Kitazato, K., additional, Okazaki, T., additional, Fujihara, T., additional, Nakajima, K., additional, Mure, H., additional, Kuwayama, K., additional, Hara, T., additional, Nagahiro, S., additional, Hill, L., additional, Botfield, H., additional, Hossain-Ibrahim, K., additional, Logan, A., additional, Cruickshank, G., additional, Liu, Y., additional, Gilbert, M., additional, Kyprianou, N., additional, Rangnekar, V., additional, Horbinski, C., additional, Hu, Y., additional, Vo, C., additional, Li, Z., additional, Ke, C., additional, Ru, N., additional, Hess, K. R., additional, Linskey, M. E., additional, Zhou, Y.-a. H., additional, Hu, F., additional, Vinnakota, K., additional, Wolf, S., additional, Kettenmann, H., additional, Jackson, P. J., additional, Larson, J. D., additional, Beckmann, D. A., additional, Moriarity, B. S., additional, Largaespada, D. A., additional, Jalali, S., additional, Agnihotri, S., additional, Singh, S., additional, Burrell, K., additional, Croul, S., additional, Zadeh, G., additional, Kang, S.-H., additional, Yu, M. O., additional, Song, N.-H., additional, Park, K.-J., additional, Chi, S.-G., additional, Chung, Y.-G., additional, Kim, S. K., additional, Kim, J. W., additional, Kim, J. Y., additional, Kim, J. E., additional, Choi, S. H., additional, Kim, T. M., additional, Lee, S.-H., additional, Kim, S.-K., additional, Park, S.-H., additional, Kim, I. H., additional, Park, C.-K., additional, Jung, H.-W., additional, Koldobskiy, M., additional, Ahmed, I., additional, Ho, G., additional, Snowman, A., additional, Raabe, E., additional, Eberhart, C., additional, Snyder, S., additional, Gugel, I., additional, Bornemann, A., additional, Pantazis, G., additional, Mack, S., additional, Shih, D., additional, Sabha, N., additional, Tatagiba, M., additional, Krischek, B., additional, Schulte, A., additional, Liffers, K., additional, Kathagen, A., additional, Riethdorf, S., additional, Westphal, M., additional, Lamszus, K., additional, Lee, J. S., additional, Xiao, J., additional, Patel, P., additional, Schade, J., additional, Wang, J., additional, Deneen, B., additional, Song, H.-R., additional, Leiss, L., additional, Gjerde, C., additional, Saed, H., additional, Rahman, A., additional, Lellahi, M., additional, Enger, P. O., additional, Leung, R., additional, Gil, O., additional, Lei, L., additional, Canoll, P., additional, Sun, S., additional, Lee, D., additional, Ho, A. S. W., additional, Pu, J. K. S., additional, Zhang, X.-q., additional, Lee, N. P., additional, Dat, P. J. R., additional, Leung, G. K. K., additional, Loetsch, D., additional, Steiner, E., additional, Holzmann, K., additional, Pirker, C., additional, Hlavaty, J., additional, Petznek, H., additional, Hegedus, B., additional, Garay, T., additional, Mohr, T., additional, Sommergruber, W., additional, Lukiw, W. J., additional, Jones, B. M., additional, Zhao, Y., additional, Bhattacharjee, S., additional, Culicchia, F., additional, Magnus, N., additional, Garnier, D., additional, Meehan, B., additional, McGraw, S., additional, Hashemi, M., additional, Lee, T. H., additional, Milsom, C., additional, Gerges, N., additional, Trasler, J., additional, Pawlinski, R., additional, Mackman, N., additional, Rak, J., additional, Maherally, Z., additional, Thorne, A., additional, An, Q., additional, Barbu, E., additional, Fillmore, H., additional, Pilkington, G., additional, Tan, S. L., additional, Tan, S., additional, Choi, S., additional, Potts, C., additional, Ford, D. A., additional, Nahle, Z., additional, Kenney, A. M., additional, Matlaf, L., additional, Khan, S., additional, Zider, A., additional, Singer, E., additional, Cobbs, C., additional, Soroceanu, L., additional, McFarland, B. C., additional, Hong, S. W., additional, Rajbhandari, R., additional, Twitty, G. B., additional, Gray, G. K., additional, Yu, H., additional, Benveniste, E. N., additional, Nozell, S. E., additional, Minata, M., additional, Kim, S., additional, Mao, P., additional, Kaushal, J., additional, Nakano, I., additional, Mizowaki, T., additional, Sasayama, T., additional, Tanaka, K., additional, Mizukawa, K., additional, Nishihara, M., additional, Nakamizo, S., additional, Tanaka, H., additional, Kohta, M., additional, Hosoda, K., additional, Kohmura, E., additional, Moeckel, S., additional, Meyer, K., additional, Leukel, P., additional, Bogdahn, U., additional, Riehmenschneider, M. J., additional, Bosserhoff, A. K., additional, Spang, R., additional, Hau, P., additional, Mukasa, A., additional, Watanabe, A., additional, Ogiwara, H., additional, Aburatani, H., additional, Mukherjee, J., additional, Obha, S., additional, See, W., additional, Pieper, R., additional, Otsuka, R., additional, Kung, D., additional, Sinha, T., additional, Meares, G., additional, Nozell, S., additional, Ott, M., additional, Litzenburger, U., additional, Rauschenbach, K., additional, Bunse, L., additional, Pusch, S., additional, Ochs, K., additional, Sahm, F., additional, Opitz, C., additional, von Deimling, A., additional, Wick, W., additional, Platten, M., additional, Peruzzi, P., additional, Read, R., additional, Fenton, T., additional, Wykosky, J., additional, Vandenberg, S., additional, Babic, I., additional, Iwanami, A., additional, Yang, H., additional, Mischel, P., additional, Thomas, J., additional, Ronellenfitsch, M. W., additional, Thiepold, A. L., additional, Harter, P. N., additional, Mittelbronn, M., additional, Steinbach, J. P., additional, Rybakova, Y., additional, Kalen, A., additional, Sarsour, E., additional, Goswami, P., additional, Silber, J., additional, Harinath, G., additional, Aldaz, B., additional, Fabius, A. W. M., additional, Turcan, S., additional, Chan, T. A., additional, Huse, J. T., additional, Sonabend, A. M., additional, Bansal, M., additional, Guarnieri, P., additional, Soderquist, C., additional, Yun, J., additional, Kennedy, B., additional, Sisti, J., additional, Bruce, S., additional, Bruce, R., additional, Shakya, R., additional, Ludwig, T., additional, Rosenfeld, S., additional, Sims, P. A., additional, Bruce, J. N., additional, Califano, A., additional, Stockhausen, M.-T., additional, Kristoffersen, K., additional, Olsen, L. S., additional, Poulsen, H. S., additional, Stringer, B., additional, Day, B., additional, Barry, G., additional, Piper, M., additional, Jamieson, P., additional, Ensbey, K., additional, Bruce, Z., additional, Richards, L., additional, Boyd, A., additional, Sufit, A., additional, Burleson, T., additional, Le, J. P., additional, Keating, A. K., additional, Sundstrom, T., additional, Varughese, J. K., additional, Harter, P., additional, Prestegarden, L., additional, Petersen, K., additional, Azuaje, F., additional, Tepper, C., additional, Ingham, E., additional, Even, L., additional, Johnson, S., additional, Skaftnesmo, K. O., additional, Lund-Johansen, M., additional, Bjerkvig, R., additional, Ferrara, K., additional, Thorsen, F., additional, Takeshima, H., additional, Yamashita, S., additional, Yokogami, K., additional, Mizuguchi, S., additional, Nakamura, H., additional, Kuratsu, J., additional, Fukushima, T., additional, Morishita, K., additional, Tang, Y., additional, Vaka, D., additional, Chen, S., additional, Ponnuswami, A., additional, Cho, Y.-J., additional, Monje, M., additional, Nakamura, T., additional, Cahill, D., additional, Tiemann, K., additional, Hedman, H., additional, Niclou, S. P., additional, Timmer, M., additional, Tjiong, R., additional, Rohn, G., additional, Goldbrunner, R., additional, Stavrinou, P., additional, Perrech, M., additional, Tokita, M., additional, Mikheev, S., additional, Sellers, D., additional, Mikheev, A., additional, Kosai, Y., additional, Rostomily, R., additional, Tritschler, I., additional, Seystahl, K., additional, Schroeder, J. J., additional, Weller, M., additional, Wade, A., additional, Robinson, A. E., additional, Phillips, J. J., additional, Gong, Y., additional, Ma, Y., additional, Cheng, Z., additional, Thompson, R., additional, Fan, Q.-W., additional, Cheng, C., additional, Gustafson, W., additional, Charron, E., additional, Zipper, P., additional, Wong, R., additional, Chen, J., additional, Lau, J., additional, Knobbe-Thosen, C., additional, Jura, N., additional, Reifenberger, G., additional, Shokat, K., additional, Weiss, W., additional, Wu, S., additional, Hu, J., additional, Taylor, T., additional, Villa, G. R., additional, Mischel, P. S., additional, Gonias, S. L., additional, Yamashita, D., additional, Kondo, T., additional, Takahashi, H., additional, Inoue, A., additional, Kohno, S., additional, Harada, H., additional, Ohue, S., additional, Ohnishi, T., additional, Li, P., additional, Ng, J., additional, Yuelling, L., additional, Du, F., additional, Curran, T., additional, Yang, Z.-j., additional, Zhu, D., additional, Castellino, R. C., additional, Van Meir, E. G., additional, Begum, G., additional, Wang, Q., additional, Yang, S.-S., additional, Lin, S.-H., additional, and Kahle, K., additional

Published
2013
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230. L’IRM 7 Tesla de la prostate : une imagerie haute définition prometteuse pour assister l’analyse histologique des pièces de prostatectomie radicale

Author

Durand, M., primary, Robinson, B., additional, Aronowitz, E., additional, Fish, J., additional, Srivastava, A., additional, Sooriakumaran, P., additional, Mtui, J., additional, Brooks, D., additional, Leung, R., additional, Gumpeni, N., additional, Shih, G., additional, Ng, A., additional, Tu, J., additional, Arnaud, P., additional, Bensaid, R., additional, Mentine, N., additional, Rouscoff, Y., additional, Carpentier, X., additional, Chevallier, D., additional, Amiel, J., additional, Tewari, A.K., additional, and Ballon, D., additional

Published
2012
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231. L’imagerie multiphotonique in vivo de la capsule prostatique : un outil prometteur pour la visualisation peropératoire des nerfs périprostatiques en temps réel

Author

Durand, M., primary, Aggarwal, A., additional, Robinson, B., additional, Sooriakumaran, P., additional, Groover, S., additional, Srivastava, A., additional, Mtui, J., additional, Brooks, D., additional, Flomenbaum, D., additional, Sterling, J., additional, Leung, R., additional, Herman, M., additional, Zipfel, W., additional, Webb, W., additional, Maxfield, F., additional, Mukherjee, S., additional, Arnaud, P., additional, Bensaid, R., additional, Mentine, N., additional, Rouscoff, Y., additional, Carpentier, X., additional, Chevallier, D., additional, Amiel, J., additional, and Tewari, A.-K., additional

Published
2012
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232. LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY

Author

Yang, F. H., primary, Zhang, B., additional, Zhou, D. J., additional, Bie, L., additional, Tom, M. W., additional, Drummond, D. C., additional, Nicolaides, T., additional, Mueller, S., additional, Banerjee, A., additional, Park, J. W., additional, Prados, M. D., additional, James, D. C., additional, Gupta, N., additional, Hashizume, R., additional, Strohbehn, G. W., additional, Zhou, J., additional, Fu, M., additional, Patel, T. R., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Xie, Q., additional, Johnson, J., additional, Bradley, R., additional, Ascierto, M. L., additional, Kang, L., additional, Koeman, J., additional, Marincola, F. M., additional, Briggs, M., additional, Tanner, K., additional, Vande Woude, G. F., additional, Tanaka, S., additional, Klofas, L. K., additional, Wakimoto, H., additional, Borger, D. R., additional, Iafrate, A. J., additional, Batchelor, T. T., additional, Chi, A. S., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Rizk, E., additional, Harbaugh, K., additional, Connor, J. R., additional, Sarkar, G., additional, Curran, G. L., additional, Jenkins, R. B., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Fujii, K., additional, Ishida, J., additional, Shimazu, Y., additional, Date, I., additional, Ebsworth, K., additional, Walters, M. J., additional, Ertl, L. S., additional, Wang, Y., additional, Berahovich, R. D., additional, Zhang, P., additional, Powers, J. P., additional, Liu, S.-C., additional, Al Omran, R., additional, Sullivan, T. J., additional, Jaen, J. C., additional, Brown, M., additional, Schall, T. J., additional, Yusuke, N., additional, Shimizu, S., additional, Shishido-Hara, Y., additional, Shiokawa, Y., additional, Nagane, M., additional, Wang, J., additional, Sai, K., additional, Chen, F.-R., additional, Chen, Z.-P., additional, Shi, Z., additional, Zhang, J., additional, Zhang, K., additional, Han, L., additional, Chen, L., additional, Qian, X., additional, Zhang, A., additional, Wang, G., additional, Jia, Z., additional, Pu, P., additional, Kang, C., additional, Kong, L.-Y., additional, Doucette, T. A., additional, Ferguson, S. D., additional, Hachem, J., additional, Yang, Y., additional, Wei, J., additional, Priebe, W., additional, Fuller, G. N., additional, Qiao, W., additional, Rao, G., additional, Heimberger, A. B., additional, Chen, P.-Y., additional, Ozawa, T., additional, Drummond, D., additional, Santos, R., additional, Torre, J. D., additional, Ng, C., additional, Lepe, E. L., additional, Butowski, N., additional, Prados, M., additional, Bankiewicz, K., additional, James, C. D., additional, Cheng, Z., additional, Gong, Y., additional, Ma, Y., additional, Muller-Knapp, S., additional, Knapp, S., additional, Antonio Chiocca, E., additional, Kaur, B., additional, Yu, J. S., additional, Judkowski, V., additional, Bunying, A., additional, Ji, J., additional, Li, Z., additional, Bender, J., additional, Pinilla, C., additional, Srinivasan, V., additional, Dombovy-Johnson, M., additional, Carson-Walter, E., additional, Walter, K., additional, Xu, Z., additional, Popp, B., additional, Schlesinger, D., additional, Gray, L., additional, Sheehan, J., additional, Keir, S. T., additional, Friedman, H. S., additional, Bigner, D. D., additional, Kut, C., additional, Tyler, B., additional, McVeigh, E., additional, Li, X., additional, Herzka, D., additional, Grossman, S., additional, Lasky, J. L., additional, Panosyan, E., additional, Meisen, W. H., additional, Hardcastle, J., additional, Wojton, J., additional, Wohleb, E., additional, Alvarez-Breckenridge, C., additional, Nowicki, M., additional, Godbout, J., additional, Lee, S. Y., additional, Sheehan, J. M., additional, Yin, S., additional, Kaluz, S., additional, Devi, S. N., additional, de Noronha, R., additional, Nicolaou, K. C., additional, Van Meir, E. G., additional, Lachowicz, J. E., additional, Demeule, M., additional, Che, C., additional, Tripathy, S., additional, Jarvis, S., additional, Currie, J.-C., additional, Regina, A., additional, Nguyen, T., additional, Castaigne, J.-P., additional, Zielinska-Chomej, K., additional, Mohanty, C., additional, Viktorsson, K., additional, Lewensohn, R., additional, Driscoll, J. J., additional, Alsidawi, S., additional, Warnick, R. E., additional, Rixe, O., additional, deCarvalho, A. C., additional, Irtenkauf, S., additional, Hasselbach, L., additional, Xin, H., additional, Mikkelsen, T., additional, Sherman, J. H., additional, Siu, A., additional, Volotskova, O., additional, Keidar, M., additional, Gibo, D. M., additional, Dickinson, P., additional, Robertson, J., additional, Rossmeisl, J., additional, Debinski, W., additional, Nair, S., additional, Schmittling, R., additional, Boczkowski, D., additional, Archer, G., additional, Sampson, J. H., additional, Mitchell, D. A., additional, Miller, I. S., additional, Didier, S., additional, Murray, D. W., additional, Issaivanan, M., additional, Coniglio, S. J., additional, Segall, J. E., additional, Al-Abed, Y., additional, Symons, M., additional, Fotovati, A., additional, Hu, K., additional, Triscott, J., additional, Bacha, J., additional, Brown, D. M., additional, Dunn, S. E., additional, Daniels, D. J., additional, Peterson, T. E., additional, Dietz, A. B., additional, Knutson, G. J., additional, Parney, I. F., additional, Diaz, R. J., additional, Golbourn, B., additional, Picard, D., additional, Smith, C., additional, Huang, A., additional, Rutka, J., additional, Saito, N., additional, Fu, J., additional, Yao, J., additional, Wang, S., additional, Koul, D., additional, Yung, W. K. A., additional, Yuan, Y., additional, Sulman, E. P., additional, Colman, H., additional, Lang, F. F., additional, Slat, E. A., additional, Herzog, E. D., additional, Rubin, J. B., additional, Carminucci, A. S., additional, Amendolara, B., additional, Leung, R., additional, Lei, L., additional, Canoll, P., additional, Bruce, J. N., additional, Wojton, J. A., additional, Chu, Z., additional, Kwon, C.-H., additional, Chow, L. M., additional, Palascak, M., additional, Franco, R., additional, Bourdeau, T., additional, Thornton, S., additional, Qi, X., additional, Kitange, G. J., additional, Mladek, A. C., additional, Su, D., additional, Carlson, B. L., additional, Schroeder, M. A., additional, Pokorny, J. L., additional, Bakken, K. K., additional, Gupta, S. K., additional, Decker, P. A., additional, Wu, W., additional, Sarkaria, J. N., additional, Oddou, M. P., additional, Mollard, A., additional, Call, L. T., additional, Vakayalapati, H., additional, Warner, S. L., additional, Sharma, S., additional, Bearss, D. J., additional, Chen, T. C., additional, Cho, H., additional, Wang, W., additional, Hofman, F. M., additional, Flores, C. T., additional, Snyder, D., additional, Sanchez-Perez, L., additional, Pham, C., additional, Friedman, H., additional, Woolf, E., additional, Abdelwahab, M. G., additional, Turner, G., additional, Preul, M. C., additional, Lynch, A., additional, Rho, J. M., additional, Scheck, A. C., additional, Salphati, L., additional, Heffron, T. P., additional, Alicke, B., additional, Barck, K., additional, Carano, R. A., additional, Cheong, J., additional, Greve, J., additional, Lee, L. B., additional, Nishimura, M., additional, Pang, J., additional, Plise, E. G., additional, Reslan, H. B., additional, Zhang, X., additional, GOuld, S. G., additional, Olivero, A. G., additional, Phillips, H. S., additional, Zadeh, G., additional, Jalali, S., additional, Voce, D., additional, Wei, Z., additional, Shijun, K., additional, Nikolai, K., additional, Josh, W., additional, Clayton, C., additional, Bakhtiar, Y., additional, Alkins, R., additional, Burgess, A., additional, Ganguly, M., additional, Wels, W., additional, Hynynen, K., additional, Li, Y. M., additional, Jun, H., additional, Daniel, V., additional, Walter, H. A., additional, Nakashima, H., additional, Nguyen, T. T., additional, Shalkh, I., additional, Goins, W. F., additional, Chiocca, E. A., additional, Pyko, I. V., additional, Nakada, M., additional, Furuyama, N., additional, Lei, T., additional, Hayashi, Y., additional, Kawakami, K., additional, Minamoto, T., additional, Fedulau, A. S., additional, and Hamada, J.-i., additional

Published
2012
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242. 925 IL28B GENE VARIANTS AND METABOLIC PROFILE IN PATIENTS WITH GENOTYPE 1 CHRONIC HEPATITIS C

Author

Rosso, C., primary, Abate, M.L., additional, Leung, R., additional, Booth, D., additional, Mezzabotta, L., additional, Carenzi, S., additional, Caviglia, G.P., additional, Salamone, F., additional, Gambino, R., additional, Cassader, M., additional, Rizzetto, M., additional, Smedile, A., additional, George, J., additional, and Bugianesi, E., additional

Published
2012
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248. F-1 IL28B gene variants and metabolic profile in patients with genotype 1 chronic hepatitis C

Author

Rosso, C., primary, Abate, M.L., additional, Leung, R., additional, Booth, D., additional, Mezzabotta, L., additional, Carenzi, S., additional, Caviglia, G.P., additional, Salamone, F., additional, Gambino, R., additional, Cassader, M., additional, Rizzetto, M., additional, Smedile, A., additional, George, J., additional, and Bugianesi, E., additional

Published
2012
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250. Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis

Author

Zoltewicz, J S, Zoltewicz, J S, Stewart, N J, Leung, R, Peterson, A S, Zoltewicz, J S, Zoltewicz, J S, Stewart, N J, Leung, R, and Peterson, A S

Abstract

Atrophins are evolutionarily conserved proteins that are thought to act as transcriptional co-repressors. Mammalian genomes contain two atrophin genes. Dominant polyglutamine-expanded alleles of atrophin 1 have been identified as the cause of dentatorubralpallidoluysian atrophy, an adult-onset human neurodegenerative disease with similarity to Huntington's. In a screen for recessive mutations that disrupt patterning of the early mouse embryo, we identified a line named openmind carrying a mutation in atrophin 2. openmind homozygous; embryos exhibit a variety of patterning defects that first appear at E8.0. Defects include a specific failure in ventralization of the anterior neural plate, loss of heart looping and irregular partitioning of somites. In mutant embryos, Shh expression fails to initiate along the anterior midline at E8.0, and Fgf8 is delocalized from the anterior neural ridge at E8.5, revealing a crucial role for atrophin 2 in the formation and function of these two signaling centers. Atrophin 2 is also required for normal organization of the apical ectodermal ridge, a signaling center that directs limb pattern. Elevated expression of atrophin 2 in neurons suggests it may interact with atrophin 1 in neuronal development or function. We further show that atrophin 2 associates with histone deacetylase 1 in mouse embryos, providing a biochemical link between Atr2 and a chromatin-modifying enzyme. Based on our results, and on those of others, we propose that atrophin proteins act as transcriptional co-repressors during embryonic development.

Published
2004

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