612 results on '"Lei, Guanghua"'
Search Results
202. Outcomes of Anterior Cruciate Ligament Reconstruction Using Single-Bundle Versus Double-Bundle Technique: Meta-analysis of 19 Randomized Controlled Trials
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Xu, Mai, primary, Gao, Shuguang, additional, Zeng, Chao, additional, Han, Rui, additional, Sun, Jinpeng, additional, Li, Hui, additional, Xiong, Yilin, additional, and Lei, Guanghua, additional
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- 2013
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203. Acupuncture for Chronic Low Back Pain in Long-Term Follow-Up: A Meta-Analysis of 13 Randomized Controlled Trials
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Xu, Mai, primary, Yan, Shi, additional, Yin, Xu, additional, Li, Xiuyang, additional, Gao, Shuguang, additional, Han, Rui, additional, Wei, Licheng, additional, Luo, Wei, additional, and Lei, Guanghua, additional
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- 2013
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204. Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13
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Xu, Mai, primary, Zhang, Lu, additional, Zhao, Lei, additional, Gao, Shuguang, additional, Han, Rui, additional, Su, Dazhi, additional, and Lei, Guanghua, additional
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- 2012
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205. Apoptotic Neutrophil Membrane-Camouflaged Liposomes for Dually Targeting Synovial Macrophages and Fibroblasts to Attenuate Osteoarthritis
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Deng, Caifeng, Chen, Yuxiao, Zhao, Xuan, Yu, Liukang, Xiao, Yongbing, Li, Hui, Zhang, Yuqing, Ai, Kelong, Zhou, Dongfang, Bai, Xiaochun, Gong, Tao, Wei, Jie, Zeng, Chao, and Lei, Guanghua
- Abstract
No current pharmacological approach is capable of simultaneously inhibiting the symptomatology and structural progression of osteoarthritis. M1 macrophages and activated synovial fibroblasts (SFs) mutually contribute to the propagation of joint pain and cartilage destruction in osteoarthritis. Here, we report the engineering of an apoptotic neutrophil membrane-camouflaged liposome (termed “NM@Lip”) for precise delivery of triamcinolone acetonide (TA) by dually targeting M1 macrophages and activated SFs in osteoarthritic joints. NM@Lip has a high cellular uptake in M1 macrophages and activated SFs. Furthermore, TA-loaded NM@Lip (TA-NM@Lip) effectively repolarizes M1 macrophages to the M2 phenotype and transforms pathological SFs to the deactivated phenotype by inhibiting the PI3K/Akt pathway. NM@Lip retains in the joint for up to 28 days and selectively distributes into M1 macrophages and activated SFs in synovium with low distribution in cartilage. TA-NM@Lip decreases the levels of pro-inflammatory cytokines, chemokines, and cartilage-degrading enzymes in osteoarthritic joints. In a rodent model of osteoarthritis-related pain, a single intra-articular TA-NM@Lip injection attenuates synovitis effectively and achieves complete pain relief with long-lasting effects. In a rodent model of osteoarthritis-related joint degeneration, repeated intra-articular TA-NM@Lip injections induce no obvious cartilage damage and effectively attenuate cartilage degeneration. Taken together, TA-NM@Lip represents a promising nanotherapeutic approach for osteoarthritis therapy.
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- 2023
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206. Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study
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Lyu, Houchen, Zhao, Sizheng Steven, Zhang, Licheng, Wei, Jie, Li, Xiaoxiao, Li, Hui, Liu, Yi, Yin, Pengbin, Norvang, Vibeke, Yoshida, Kazuki, Tedeschi, Sara K, Zeng, Chao, Lei, Guanghua, Tang, Peifu, and Solomon, Daniel H
- Abstract
ObjectiveTo estimate the effect of denosumab compared with oral bisphosphonates on reducing the risk of type 2 diabetes in adults with osteoporosis.DesignPopulation based study involving emulation of a randomized target trial using electronic health records.SettingIQVIA Medical Research Data primary care database in the United Kingdom, 1995-2021.ParticipantsAdults aged 45 years or older who used denosumab or an oral bisphosphonate for osteoporosis.Main outcome measuresThe primary outcome was incident type 2 diabetes, as defined by diagnostic codes. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence intervals, comparing denosumab with oral bisphosphonates using an as treated approach.Results4301 new users of denosumab were matched on propensity score to 21 038 users of an oral bisphosphonate and followed for a mean of 2.2 years. The incidence rate of type 2 diabetes in denosumab users was 5.7 (95% confidence interval 4.3 to 7.3) per 1000 person years and in oral bisphosphonate users was 8.3 (7.4 to 9.2) per 1000 person years. Initiation of denosumab was associated with a reduced risk of type 2 diabetes (hazard ratio 0.68, 95% confidence interval 0.52 to 0.89). Participants with prediabetes appeared to benefit more from denosumab compared with an oral bisphosphonate (hazard ratio 0.54, 0.35 to 0.82), as did those with a body mass index ≥30 (0.65, 0.40 to 1.06).ConclusionsIn this population based study, denosumab use was associated with a lower risk of incident type 2 diabetes compared with oral bisphosphonate use in adults with osteoporosis. This study provides evidence at a population level that denosumab may have added benefits for glucose metabolism compared with oral bisphosphonates.
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- 2023
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207. Incidence, patterns and risk factors for readmission following knee arthroplasty in China: A national retrospective cohort study.
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Long, Huizhong, Xie, Dongxing, Li, Xiaoxiao, Jiang, Qiao, Zhou, Zhiye, Wang, Haibo, Zeng, Chao, and Lei, Guanghua
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Background: Limited data exist on readmission following knee arthroplasty (KA) in countries without well-established referral or extended care systems. This study aimed to investigate the incidence, patterns and risk factors for readmission following KA in China.Material and Methods: In this national retrospective cohort study, we reviewed 167,265 primary KAs registered in the Hospital Quality Monitoring System in China between 2013 and 2018. Readmissions after KA within 30 and 90 days were evaluated. The causes for readmission were identified and classified as surgical or medical. The potential risk factors of readmission were assessed using multivariable logistic regression.Results: 4017 (2.4%) patients readmitted within 30 days, and 7258 (4.3%) patients readmitted within 90 days. The readmission rate exhibited a downward trend during the period from 2013 to 2018 (2.7%-2.3% for 30-day readmission; 4.5%-4.2% for 90-day readmission). Surgical causes contributed to 54.3% readmissions within 30 days and 47.3% readmissions within 90 days. Wound infection/complication, joint pain, and thromboembolism were the most frequently reported reasons for surgical readmission. Older age, male sex, single marital status, non-osteoarthritis indication, a high comorbidity index, non-provincial hospitals, low hospital volume, and longer length of stay were associated with an increased risk of readmission. The geographic regions of hospitals contributed greatly to the variety of readmissions.Conclusion: The readmission rate following KA decreased from 2013 to 2018. Surgery-related causes, especially wound infection/complication and pain, accounted for a large proportion. Both patient and hospital factors were associated with readmissions. Improved primary care and targeted measures are needed to help further prevent readmissions and optimize resource utilization. [ABSTRACT FROM AUTHOR]- Published
- 2022
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208. Role of osteopontin in rheumatoid arthritis.
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Zhang, Fangjie, Luo, Wei, Li, Yusheng, Gao, Shuguang, and Lei, Guanghua
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RHEUMATOID arthritis treatment ,OSTEOPONTIN ,DRUG efficacy ,DISEASE susceptibility ,TARGETED drug delivery ,THERAPEUTICS - Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and destruction of synovial joints, leading to severe disability and premature mortality. RA is a multifactorial disease with genetic, environmental, and stochastic components related to its susceptibility. It has been demonstrated that the expression of osteopontin (OPN) is upregulated in the RA patients. Numerous studies have indicated that the full-length OPN or even OPN fragments, such as thrombin-cleaved OPN and its receptors, play the key roles in RA pathogenesis. Therapeutic application of siRNA to target OPN or neutralizing antibodies related to OPN epitopes in RA animal models are in progress, and some results are encouraging. However, there is a long way to go along with the clinical trials. This review focuses on the recent development in research associated with the OPN role in the pathogenesis of RA and provides insights concerning the OPN targeting as therapeutic approaches for patients with RA. [ABSTRACT FROM AUTHOR]
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- 2015
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209. EFFECT OF OSTEOPONTIN ON EXPRESSION OF MATRIX METALLOPROTEINASE 13 IN HUMAN KNEE OSTEOARTHRITIC CHONDROCYTES.
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JIANG Wei, LEI Guanghua, LIN Bowen, WANG Hua, LÜ Meng, GAO Shuguang, ZHANG Fangjie, and ZENG Chao
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- 2014
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210. Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis
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Bai, Ruijun, Miao, Michael Z., Li, Hui, Wang, Yiqing, Hou, Ruixue, He, Ke, Wu, Xuan, Jin, Hongyu, Zeng, Chao, Cui, Yang, and Lei, Guanghua
- Abstract
Background: Dietary magnesium deficiency, which is common in modern diet, has been associated with osteoarthritis (OA) susceptibility. Despite this clinical association, no study has addressed if dietary magnesium deficiency accelerates OA development, especially at molecular level. This study aimed to explore aggravating effects of dietary magnesium deficiency on cartilage damage in an injury-induced murine OA model and to determine the underlying mechanism. Methods: Twelve-week-old C57BL/6J mice subject to injury-induced OA modeling were randomized into different diet groups in which the mice were fed a diet with daily recommended magnesium content (500 mg/kg) or diets with low magnesium content (100 or 300 mg/kg). Articular cartilage damage was evaluated using the OARSI score. To determine molecular mechanisms in vitro, mouse chondrocytes were treated with media of low magnesium conditions at 0.1 and 0.4 mM, compared with normal magnesium condition at 0.7 mM as control. Anabolic and catabolic factors, autophagy markers, β-catenin, Wnt ligands, and a magnesium channel transient receptor potential cation channel subfamily member 7 (TRPM7) were analyzed by quantitative real-time PCR and immunoblotting. Autolysosomes were detected by DALGreen staining via fluorescence microscopy and autophagosomes were evaluated by transmission electron microscopy. Autophagy markers, β-catenin, and TRPM7 were assessed in vivo in the mouse cartilage, comparing between dietary magnesium deficiency and normal diet, by immunohistochemistry. Results: Dietary magnesium deficiency aggravated injury-induced cartilage damage, indicated by significant higher OARSI scores. Autophagy markers LC3-II and Beclin-1 were decreased both in low magnesium diet-fed mice and low magnesium-treated chondrocytes. The number of autolysosomes and autophagosomes was also reduced under low magnesium conditions. Moreover, magnesium deficiency induced decreased anabolic and increased catabolic effect of chondrocytes which could be restored by autophagy activator rapamycin. In addition, reduced autophagy under low magnesium conditions is mediated by activated Wnt/β-catenin signaling. The expression of TRPM7 also decreased in low magnesium diet-fed mice, indicating that downstream changes could be regulated through this channel. Conclusions: Dietary magnesium deficiency contributes to OA development, which is mediated by reduced autophagy through Wnt/β-catenin signaling activation. These findings indicated potential benefits of adequate dietary magnesium for OA patients or those individuals at high risk of OA.
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- 2022
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211. Anterior cruciate ligament tear increases the risk of venous thromboembolism: a population-based cohort study.
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Xiong, Yilin, Li, Xiaoxiao, Lei, Guanghua, Zeng, Chao, Wei, Jie, Ding, Xiang, and Li, Hui
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ANTERIOR cruciate ligament injuries , *THROMBOEMBOLISM , *ANTERIOR cruciate ligament surgery , *VENOUS thrombosis , *PROPORTIONAL hazards models , *COHORT analysis - Abstract
Purpose: Previous studies highlighted an increased risk of venous thromboembolism (VTE) among patients with anterior cruciate ligament reconstruction (ACLR); however, the risk for those with ACL tear but without undergoing ACLR has not been reported yet. The aim of this study was to evaluate the risk of VTE among ACL tear individuals with or without ACLR derived from the general population. Methods: A cohort study was conducted using data from the IQVIA Medical Research Database of the United Kingdom. Up to five non-ACL tear individuals (n = 22,235) were matched to each case of ACL tear (n = 4474) by age, sex, body mass index and entry-time. The relation of ACL tear to VTE [pulmonary embolism (PE) and deep vein thrombosis (DVT)] was examined using a multivariable Cox proportional hazard model. A sub-cohort analysis, in which the ACL tear individuals were stratified into those with ACLR and those without ACLR, was also conducted. Results: VTE developed in 13 individuals with ACL tear and nine individuals without ACL tear (incidence rates: 3.1 vs. 0.4/1000 person-years), with multivariable-adjusted hazard ratio (HR) being 6.59 (95% CI 2.28–19.08) in 1-year follow-up. For ACL tear individuals with ACLR, the HR was 11.44 (95% CI 2.71–48.28), and for those without ACLR, the HR was 6.02 (95% CI 1.44–24.25), compared with individuals without ACL tear. Conclusion: This large-sample population-based cohort study provides the first evidence on an increased risk of VTE in ACL tear individuals regardless of subsequent ACLR, which supports the necessity for monitoring venous-thromboembolic complications in the target population, including those without ACLR. Level of evidence: III. [ABSTRACT FROM AUTHOR]
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- 2023
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212. Col10a1gene expression and chondrocyte hypertrophy during skeletal development and disease
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Lu, Yaojuan, Qiao, Longwei, Lei, Guanghua, Mira, Ranim, Gu, Junxia, and Zheng, Qiping
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The type X collagen gene, COL10A1, is specifically expressed by hypertrophic chondrocytes during endochondral ossification. Endochondral ossification is a well-coordinated process that involves a cartilage intermediate and leads to formation of most of the skeleton in vertebrates during skeletogenesis. Chondrocyte hypertrophy is a critical stage of endochondral ossification linking both bone and cartilage development. Given its specific association with chondrocyte hypertrophy, type X collagen plays essential roles in endochondral ossification. It was previously shown that transgenic mice with mutant type X collagen develop variable skeleton-hematopoietic abnormalities indicating defective endochondral ossification, while mutations and abnormal expression of human COL10A1cause abnormal chondrocyte hypertrophy that has been seen in many skeletal disorders, including skeletal chondrodysplasia and osteoarthritis. In this review, we summarized the skeletal chondrodysplasia with COL10A1gene mutation that shows growth plate defect. We also reviewed recent studies that correlate the type X collagen gene expression and chondrocyte hypertrophy with osteoarthritis. Due to its significant clinical relevance, the type X collagen gene regulation has been extensively studied over the past two decades. Here, we focus on recent progress characterizing the cis-enhancer elements and their binding factors that together confer hypertrophic chondrocyte-specific murine type X collagen gene (Col10a1) expression. Based on literature review and our own studies, we surmise that there are multiple factors that contribute to hypertrophic chondrocyte-specific Col10a1expression. These factors include both transactivators (such as Runx2, MEF2C etc.) and repressors (such as AP1, NFATc1, Sox9 etc.), while other co-factors or epigenetic control of Col10a1expression may not be excluded.
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- 2014
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213. A colorimetric sensor based on 4-MPBA Au@AgNPs for accurately identification of EnshiYulu tea grade.
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Guan, Yuting, Wang, Siyu, Lei, Guanghua, Hu, Zikang, Chen, Hengye, Gu, Huiwen, Yin, Xiaoli, She, Yuanbin, Long, Wanjun, and Fu, Haiyan
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DETECTORS , *DISCRIMINANT analysis , *TEA extracts , *IDENTIFICATION , *PRICES , *GREEN tea - Abstract
[Display omitted] • A novel colorimetric sensor method was constructed for distinguish ESYL grades. • The mechanism involved forming borate esters and the conversion between Ag+ and Ag0. • The accuracy of ESYL grades identification based on visual data was 95.5%. Enshi Yulu green tea (ESYL) is the most representative traditional steamed green tea in Enshi, Hubei. Different ESYL grades exhibit distinct flavors, tastes, and prices. In this study, a visual sensor based on 4-MPBA Au@AgNPs was developed for the rapid and accurate identification of ESYL grades. The recognition mechanism involved the binding of 4-MPBA Au@AgNPs with polyphenolic compounds in ESYL to form borate esters and the conversion of Ag+ to Ag0, with the generated Ag0 depositing on the surface of 4-MPBA Au@AgNPs. The results showed that the sensor can amplify the color differences of different grades of ESYL. The visual results were also validated by the partial least squares discriminant analysis model, demonstrating an enhancement in recognition accuracy from 68.2 % to 95.5 % compared to the original extraction solution. The colorimetric sensor developed in this study is expected to provide a new approach for traceability research of other foods. [ABSTRACT FROM AUTHOR]
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- 2024
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214. Current Progress and Trends in Musculoskeletal Research: Highlights of NSFC-CUHK Academic Symposium on Bone and Joint Degeneration and Regeneration
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Tuan, Rocky S., Zhang, Yingze, Chen, Lin, Guo, Quanyi, Yung, Patrick SH., Jiang, Qing, Lai, Yuxiao, Yu, Jiakuo, Luo, Jian, Xia, Jiang, Xu, Chenjie, Lei, Guanghua, Su, Jiacan, Luo, Xianghang, Zou, Weiguo, Qu, Jing, Song, Bing, Zhao, Xin, Ouyang, Hongwei, Li, Gang, Ding, Changhai, Wan, Chao, Chan, Barbara P., Yang, Liu, Xiao, Guozhi, Shi, Dongquan, Xu, Jiankun, Cheung, Louis WH., Bai, Xiaochun, Xie, Hui, Xu, Ren, Li, Zhong Alan, Chen, Di, and Qin, Ling
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- 2022
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215. Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population—the Xiangya Osteoarthritis Study
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Jiang, Ting, Yang, Tuo, Zhang, Weiya, Doherty, Michael, Zhang, Yuqing, Wei, Jie, Sarmanova, Aliya, Hall, Michelle, Yang, Zidan, Li, Jiatian, Fernandes, Gwen S., Obotiba, Abasiama D., Gohir, Sameer A., Courtney, Philip, Zeng, Chao, and Lei, Guanghua
- Abstract
Background: There is paucity of data on the prevalence of ultrasound-detected synovial abnormalities in the general population, and the relationship between synovial changes and knee pain remains unclear. We examined the prevalence of synovial abnormalities on ultrasound and the relationship of these features with knee pain and radiographic osteoarthritis (ROA) in a community sample. Methods: Participants aged 50 years or over were from the Xiangya Osteoarthritis Study, a community-based cohort study. Participants were questioned about chronic knee pain and underwent (1) ultrasonography of both knees to determine presence of synovial hypertrophy (≥ 4 mm), effusion (≥ 4 mm), and Power Doppler signal [PDS; yes/no]; and (2) standard radiographs of both knees (tibiofemoral and patellofemoral views) to determine ROA. Results: There were 3755 participants (mean age 64.4 years; women 57.4%). The prevalence of synovial hypertrophy, effusion, and PDS were 18.1% (men 20.2%; women 16.5%), 46.6% (men 49.9%; women 44.2%), and 4.9% (men 4.9%; women 5.0%), respectively, and increased with age (P for trend < 0.05). Synovial abnormalities were associated with knee pain, with adjusted odds ratios (aORs) of 2.39 (95% confidence interval [CI] 2.00–2.86) for synovial hypertrophy, 1.58 (95%CI 1.39–1.80) for effusion, and 4.36 (95%CI 3.09–6.17) for PDS. Similar associations with ROA were observed, the corresponding aORs being 4.03 (95%CI 3.38–4.82), 2.01 (95%CI 1.76–2.29), and 6.49 (95%CI 4.51–9.35), respectively. The associations between synovial hypertrophy and effusion with knee pain were more pronounced among knees with ROA than those without ROA, and the corresponding Pfor interaction were 0.004 and 0.067, respectively. Conclusions: Knee synovial hypertrophy and effusion are more common and increase with age, affecting men more than women. All three ultrasound-detected synovial abnormalities associate both with knee pain and ROA, and knee synovial hypertrophy or effusion and ROA may interact to increase the risk of knee pain.
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- 2021
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216. Macrophage migration inhibitory factor may play a protective role in osteoarthritis
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Liu, Ming, Xie, Zikun, Sun, Guang, Chen, Liujun, Qi, Dake, Zhang, Hongwei, Xiong, Jieying, Furey, Andrew, Rahman, Proton, Lei, Guanghua, and Zhai, Guangju
- Abstract
Background: Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of disability and overall diminution of quality of life in the elderly population. Currently there is no cure for OA, partly due to the large gaps in our understanding of its underlying molecular and cellular mechanisms. Macrophage migration inhibitory factor (MIF) is a procytokine that mediates pleiotropic inflammatory effects in inflammatory diseases such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, data on the role of MIF in OA is limited with conflicting results. We undertook this study to investigate the role of MIF in OA by examining MIFgenotype, mRNA expression, and protein levels in the Newfoundland Osteoarthritis Study. Methods: One hundred nineteen end-stage knee/hip OA patients, 16 RA patients, and 113 healthy controls were included in the study. Two polymorphisms in the MIFgene, rs755622, and -794 CATT
5-8 , were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and PCR followed by automated capillary electrophoresis, respectively. MIFmRNA levels in articular cartilage and subchondral bone were measured by quantitative polymerase chain reaction. Plasma concentrations of MIF, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) were measured by enzyme-linked immunosorbent assay. Results: rs755622 and -794 CATT5-8 genotypes were not associated with MIFmRNA or protein levels or OA (all p≥ 0.19). MIFmRNA level in cartilage was lower in OA patients than in controls (p= 0.028) and RA patients (p= 0.004), while the levels in bone were comparable between OA patients and controls (p= 0.165). MIF protein level in plasma was lower in OA patients than in controls (p= 3.01 × 10−10 ), while the levels of TNF-α, IL-6 and IL-1β in plasma were all significantly higher in OA patients than in controls (all p≤ 0.0007). Multivariable logistic regression showed lower MIF and higher IL-1β protein levels in plasma were independently associated with OA (OR per SD increase = 0.10 and 8.08; 95% CI = 0.04–0.19 and 4.42–16.82, respectively), but TNF-α and IL-6 became non-significant. Conclusions: Reduced MIFmRNA and protein expression in OA patients suggested MIF might have a protective role in OA and could serve as a biomarker to differentiate OA from other joint disorders.- Published
- 2021
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217. Physical Distancing Measures and Walking Activity in Middle-aged and Older Residents in Changsha, China, During the COVID-19 Epidemic Period: Longitudinal Observational Study.
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Wang, Yilun, Zhang, Yuqing, Bennell, Kim, White, Daniel Kenta, Wei, Jie, Wu, Ziying, He, Hongyi, Liu, Shaohui, Luo, Xianghang, Hu, Shuo, Zeng, Chao, and Lei, Guanghua
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VIRAL pneumonia ,RESEARCH ,SOCIAL participation ,RESEARCH methodology ,COVID-19 ,EVALUATION research ,MEDICAL cooperation ,SOCIAL isolation ,COMPARATIVE studies ,PSYCHOLOGICAL tests ,EXERCISE ,WALKING ,EPIDEMICS ,LONGITUDINAL method - Abstract
Background: Physical distancing measures taken to contain COVID-19 transmission may substantially reduce physical activity levels and cause individuals to adopt a more sedentary lifestyle.Objective: The objective of this study is to determine if there was any change in daily steps, an important component of daily physical activity, and examine risk factors for frequent low daily steps during the COVID-19 epidemic.Methods: We used data collected from the Step Study, a population-based longitudinal study of walking activity among residents aged ≥40 years in Changsha, China. Daily steps were collected via a smartphone linked to WeChat, a social networking platform. We plotted mean daily steps and the prevalence of low daily steps (≤1500 steps/day) 30 days before (reference period) and 30 days after (epidemic period) January 21, 2020 (date of the first COVID-19 case diagnosed in Changsha), and compared it with the same corresponding period from 2019. We examined the association of risk factors with the prevalence of frequent low daily steps (≤1500 steps/day for ≥14 days) using logistic regression.Results: Among 3544 participants (mean age 51.6 years; n=1226 females, 34.6%), mean daily steps dropped from 8097 to 5440 and the prevalence of low daily steps increased from 3% (2287/76,136 person-day) to 18.5% (12,951/70,183 person-day) during the reference and epidemic periods, respectively. No such phenomenon was observed during the corresponding period in 2019. Older age (P for interaction=.001) and female sex (P for interaction<.001) were both associated with a higher prevalence of frequent low daily steps and were more pronounced during the epidemic period. More education was associated with a lower prevalence of frequent low daily steps during the reference period but not the epidemic period (P for interaction=.34). Body mass index or comorbidity were not associated with frequent low daily steps during either period.Conclusions: Daily steps of Changsha residents aged ≥40 years dropped significantly during the COVID-19 period, especially among older adults and females. Although successful physical distancing, measured by the rapid downward trend in daily step counts of residents, played a critical role in the containment of the COVID-19 epidemic, our findings of an increase in the prevalence of frequent low daily steps raise concerns about unintended effects on physical activity. [ABSTRACT FROM AUTHOR]- Published
- 2020
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218. MEASUREMENT STUDY ON INCLUDED ANGLE BETWEEN TIBIA ANATOMICAL AXIS AND ANTERIOR CORTEX IN ADULTS.
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JIANG Wei, LUO Wei, ZHANG Fangjie, GAO Shuguang, XU Mai, ZENG Chao, and LEI Guanghua
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- 2013
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219. ANATOMIC FEATURES OF POSTERIOR SEPTUM OF KNEE JOINT AND ITS APPLICATION IN POSTERIOR TRANS-SEPTAL PORTAL FOR ARTHROSCOPIC SURGERY.
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SUN Jinpeng, XIONG Yilin, and LEI Guanghua
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- 2013
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220. Inflammatory potential of diet and risk of incident knee osteoarthritis: a prospective cohort study.
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Liu, Qiang, Hebert, James R., Shivappa, Nitin, Guo, Jianjun, Tao, Ke, Zeng, Chao, Lei, Guanghua, Lin, Jianhao, and Zhang, Yuqing
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- 2020
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221. In-hospital complications and readmission patterns in 13,937 patients with developmental dysplasia of the hip undergoing total hip arthroplasty: Evidence from the Chinese national database.
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Wang, Yuqing, Jiang, Qiao, Xie, Dongxing, Li, Xiaoxiao, Wang, Haibo, Zeng, Chao, Lei, Guanghua, and Yang, Tuo
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TOTAL hip replacement , *CONGENITAL hip dislocation , *PATIENT readmissions , *DATABASES , *VENOUS thrombosis , *DYSPLASIA , *TOTAL shoulder replacement ,ACETABULUM surgery - Abstract
Clarifying the prognosis and readmission patterns of patients with developmental dysplasia of the hip (DDH) following total hip arthroplasty (THA) would provide important references for clinical management for this population. Using the Chinese national inpatient database (i.e., Hospital Quality Monitoring System [HQMS]), we aimed to compare in-hospital complications and readmission patterns following THA in patients with DDH and primary osteoarthritis (OA). Patients undergoing THA for DDH and OA between 2013 and 2019 were identified using the HQMS. Demographics and clinical characteristics were compared between the two groups. After propensity score matching, in-hospital complications and readmission patterns were compared using a logistic regression model. According to the analysis of 13,937 propensity-score matched pairs, there were no significant differences in the incidence of in-hospital death (0.01 % vs 0.04 %, P = 0.142), transfusion (8.09 % vs 7.89 %, P = 0.536), wound infection (0.31 % vs 0.25 %, P = 0.364), deep venous thrombosis (0.45 % vs 0.43 %, P = 0.786), pulmonary embolism (0.03 % vs 0.05 %, P = 0.372) or all-cause readmission (2.87 % vs 3.12 %, P = 0.219) between two groups. However, DDH patients had higher surgical readmission rates than OA patients (1.43 % vs 1.14 %, P = 0.033). When analyzing causes of surgical readmission, DDH patients had increased risk of dislocation (0.37 % vs 0.21 %, P = 0.011) and aseptic loosening (0.17 % vs 0.07 %, P = 0.024) than OA patients. DDH patients had an increased risk of surgical readmission following THA, mainly driven by dislocation and aseptic loosening, which should be recognized and appropriately prevented. • DDH and OA patients had comparable complication and readmission rates after THA. • DDH had an increased risk of surgical-related readmission than OA after THA. • DDH had an increased risk of dislocation and aseptic loosening than OA after THA. [ABSTRACT FROM AUTHOR]
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- 2024
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222. Weight Loss Induced by Antiobesity Medications and All‐Cause Mortality Among Patients With Knee or Hip Osteoarthritis.
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Wei, Jie, Hunter, David, Lane, Nancy E., Wu, Jing, Zeng, Chao, Lei, Guanghua, and Zhang, Yuqing
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WEIGHT loss , *KNEE osteoarthritis , *SECONDARY analysis , *RESEARCH funding , *HYPERTENSION , *VEINS , *CAUSES of death , *CARDIOVASCULAR diseases risk factors , *DESCRIPTIVE statistics , *LONGITUDINAL method , *ANTIOBESITY agents , *TYPE 2 diabetes , *HIP osteoarthritis , *COMPARATIVE studies , *CONFIDENCE intervals , *OBESITY , *WEIGHT gain ,THROMBOEMBOLISM prevention - Abstract
Objective: The current guidelines recommend weight loss for patients with overweight or obesity and knee or hip osteoarthritis (OA); however, there is a paucity of data on the relation of weight loss to death among patients with OA. We aimed to examine the relation of the rate of weight loss induced by antiobesity medications over one year to all‐cause mortality among patients with overweight or obesity and knee or hip OA. Methods: Using the IQVIA Medical Research Database, we identified people with overweight or obesity and knee or hip OA. We emulated analyses of a hypothetical target trial to assess the effect of slow‐to‐moderate (2%–10%) or fast (≥10%) weight loss induced by the initiation of antiobesity medications within one year on all‐cause mortality and secondary outcomes over five years' follow‐up. Results: Among 6,524 participants, the five‐year all‐cause mortality rates were 5.3%, 4.0%, and 5.4% for weight gain or stable, slow‐to‐moderate weight loss, and fast weight loss arms, respectively. Compared with the weight gain or stable arm, hazard ratios of all‐cause mortality were 0.72 (95% confidence interval [CI] 0.56–0.92) for the slow‐to‐moderate weight loss arm and 0.99 (95% CI 0.67–1.44) for the fast weight loss arm. We found dose–response protective effects of weight loss on incident hypertension, type 2 diabetes, and venous thromboembolism but a slightly higher risk of cardiovascular disease, albeit not statistically significant, in the fast rate of weight loss arm than in the weight gain or stable arm and no significant relations of weight loss to the risk of cancer. Conclusion: In this population‐based study, a slow‐to‐moderate, but not fast, rate of weight loss induced by antiobesity medications is associated with a lower risk of all‐cause mortality in people with overweight or obesity and knee or hip OA. [ABSTRACT FROM AUTHOR]
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- 2024
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223. Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
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Li, Hui, Ding, Xiang, Terkeltaub, Robert, Lin, Hang, Zhang, Yuqing, Zhou, Bin, He, Ke, Li, Kun, Liu, Zhichen, Wei, Jie, Yang, Yuanheng, Xie, Hui, Zeng, Chao, and Lei, Guanghua
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Background: Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. Methods: Eighty 10-week-old male C57BL/6 mice were randomized to 6 groups: non-operation, sham-operation, destabilization of the medial meniscus (DMM)-operation with intragastric saline/metformin, and DMM-operation with intraarticular saline/metformin. Articular cartilage degeneration was examined by scanning electron microscopy (SEM) and graded using the scoring system recommended by Osteoarthritis Research Society International (OARSI). Mechanical withdrawal threshold and hind paw weight distribution were measured to assess the pain-related behavior. Cell Counting Kit-8 assay, quantificational real-time polymerase chain reaction, and western blot analysis were conducted to examine the anabolic and anti-catabolic effect of metformin and the role of AMPK in mediating its effects on interleukin-1β stimulated primary mice chondrocytes. Results: Compared with mice receiving intragastric and intraarticular saline, mice in both intragastric and intraarticular metformin displayed attenuated articular cartilage degeneration, indicated by less cartilage damage under SEM and significantly lower OARSI scores. A higher paw withdrawal threshold and a decreased weight-bearing asymmetry were observed in the intragastric and intraarticular metformin mice compared with their corresponding saline groups in DMM model of osteoarthritis. In vitro experiments showed that metformin not only decreased the level of matrix metalloproteinase 13, but also elevated type II collagen production through activating AMPK pathway. Conclusions: Metformin attenuates osteoarthritis structural worsening and modulates pain, suggesting its potential for osteoarthritis prevention or treatment.
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- 2020
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224. Machine learning-assisted visual sensor array for identifying the origin of Lilium bulbs.
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Long, Wanjun, Guan, Yuting, Lei, Guanghua, Hu, Zikang, Chen, Hengye, She, Yuanbin, and Fu, Haiyan
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SENSOR arrays , *LILIES , *PHENOL content of food , *PHENOLIC acids , *CHINESE medicine , *QUANTUM dots , *PROTON transfer reactions - Abstract
In this work, we constructed a machine learning-assisted dual-channel visual sensor array for identifying the origin of Lilium bulbs (BH). Nanogold clusters (AuNCs) and quantum dots (QDs) were selected and combined into sensor arrays. The amino acids existed in lilium bulbs could induce aggregation-induced fluorescence enhancement effect (AIEE) of AuNCs through hydrogen bonding. The hydrogen protons released from the amino acids and phenolic acids could interact with the COO- group of QDs, resulting in aggregation-caused quenching (ACQ) of QDs. Due to the different contents of amino acids and phenolic acids in BH from different origins, the sensor array can produce distinct and different fluorescent colors, such as red, blue, green and purple. In conjunction with pattern recognition by the RF model, the sensor array clearly identifies the origin of BH with 94.4% prediction accuracy. The visual sensor array constructed in this work exhibited the advantages of simplicity, speed, accuracy and portability, showing potential application prospects in identifying the origin of food and traditional Chinese medicine. [Display omitted] • A novel visual sensor array method was constructed for tracing BH origins. • The amino acids in BH could induce AIEE effect of AuNCs through hydrogen bonding. • The protonation and ET effect induced the ACQ of NAC-QDs. • The accuracy of BH origin identification based on dual-channel visual data was 94.4%. [ABSTRACT FROM AUTHOR]
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- 2024
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225. Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.
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Li, Hui, Zhou, Bin, Wu, Jing, Zhang, Yuqing, Zhang, Weiya, Doherty, Michael, Deng, Xinjia, Wang, Ning, Xie, Dongxing, Wang, Yilun, Xie, Hui, Li, Changjun, Wei, Jie, Lei, Guanghua, and Zeng, Chao
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MELATONIN , *HUMAN experimentation , *OSTEOARTHRITIS , *TOTAL hip replacement , *QUANTILE regression - Abstract
Melatonin exhibits potential for pain relief and long‐term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted a cohort study in individuals with OA to compare the number of oral analgesic prescriptions and the risk of knee/hip replacement between melatonin initiators and hypnotic benzodiazepines (i.e., active comparator) initiators using quantile regression models and Cox‐proportional hazard models, respectively. To elucidate causation, we examined the effects of melatonin on pain behaviors and explored several metabolites that may serve as potential regulatory agents of melatonin in the monoiodoacetate rat model of OA. Using data from another community‐based cohort study, that is, the Xiangya OA Study, we verified the association between the key serum metabolite and incident symptomatic knee OA. Compared with the hypnotic benzodiazepines cohort (n = 8135), the melatonin cohort (n = 813) had significantly fewer subsequent prescriptions of oral analgesics (50th percentile: 5 vs. 7, 75th percentile: 19 vs. 29, and 99th percentile: 140 vs. 162) and experienced a lower risk of knee/hip replacement (hazard ratio = 0.47, 95% Cl: 0.30–0.73) during the follow‐up period. In rats, oral melatonin alleviated pain behaviors and increased serum levels of glycine. There was an inverse association between baseline serum glycine levels and the risk of incident symptomatic knee OA in humans (n = 760). In conclusion, our findings indicate that oral melatonin shows significant potential to be a novel treatment for OA pain. The potential role of glycine in its analgesic mechanism warrants further investigation. [ABSTRACT FROM AUTHOR]
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- 2024
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226. Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative.
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Ye, Jing, Xie, Dongxing, Li, Xiaoxiao, Lu, Na, Zeng, Chao, Lei, Guanghua, Wei, Jie, and Li, Jiatian
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KNEE pain , *PHENOTYPES , *PHENOTYPIC plasticity , *OSTEOARTHRITIS , *KNEE osteoarthritis , *BODY mass index , *PAIN - Abstract
Background: Identification of knee osteoarthritis (OA) pain phenotypes, their transition patterns, and risk factors for worse phenotypes, may guide prognosis and targeted treatment; however, few studies have described them. We aimed to investigate different pain phenotypes, their transition patterns, and potential risk factors for worse pain phenotypes. Methods: Utilizing data from the Osteoarthritis Initiative (OAI), pain severity was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. We identified the activity-related pain phenotypes and estimated the transition probabilities of pain phenotypes from baseline to the 24-month using latent transition analysis. We examined the risk factors at baseline with the 24-month pain phenotypes and the transition of pain phenotypes. Results: In 4796 participants, we identified four distinct knee pain phenotypes at both baseline and 24-month follow-up: no pain, mild pain during activity (Mild P-A), mild pain during both rest and activity (Mild P-R-A), and moderate pain during both rest and activity (Mod P-R-A). 82.9% knees with no pain at baseline stayed the same at 24-month follow-up, 17.1% progressed to worse pain phenotypes. Among "Mild P-A" at baseline, 32.0% converted to no-pain, 12.8% progressed to "Mild P-R-A", and 53.2% remained. Approximately 46.1% of "Mild P-R-A" and 54.5% of "Mod P-R-A" at baseline experienced remission by 24-month. Female, non-whites, participants with higher depression score, higher body mass index (BMI), higher Kellgren and Lawrence (KL) grade, and knee injury history were more likely to be in the worse pain phenotypes, while participants aged 65 years or older and with higher education were less likely to be in worse pain phenotypes at 24-month follow-up visit. Risk factors for greater transition probability to worse pain phenotypes at 24-month included being female, non-whites, participants with higher depression score, higher BMI, and higher KL grade. Conclusions: We identified four distinct knee pain phenotypes. While the pain phenotypes remained stable in the majority of knees over 24 months period, substantial proportion of knees switched to different pain phenotypes. Several socio-demographics as well as radiographic lesions at baseline are associated with worse pain phenotypes at 24-month follow-up visit and transition of pain phenotypes. [ABSTRACT FROM AUTHOR]
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- 2024
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227. Trends, complications, and readmission of allogeneic red blood cell transfusion in primary total hip arthroplasty in china: a national retrospective cohort study.
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Jiang, Qiao, Wang, Yuqing, Xie, Dongxing, Wei, Jie, Li, Xiaoxiao, Zeng, Chao, Lei, Guanghua, and Yang, Tuo
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RED blood cell transfusion , *TOTAL hip replacement , *PATIENT readmissions , *VENOUS thrombosis , *GENERALIZED estimating equations , *BLOOD transfusion - Abstract
Introduction: Decrease in allogenic red blood cell (RBC) transfusion rates following total hip arthroplasty (THA) has been reported in the United States, but whether other countries share the same trend remains unclear. Additionally, the relation of allogenic RBC transfusion to the risk of complications in THA remains controversial. Using the Chinese national inpatient database, the current study aimed to examine trends, complications, charges, and readmission patterns of allogeneic RBC transfusion in THA. Materials and methods: Patients undergoing primary THA between 2013 and 2019 were included, and then stratified into the transfusion and the non-transfusion group based on the database transfusion records. A generalized estimating equation model was used to investigate trends in transfusion rates. After propensity-score matching, a logistic regression model was used to compare the complications, rates and causes of 30-day readmission between two groups. Results: A total of 10,270 patients with transfusion and 123,476 patients without transfusion were included. Transfusion rates decreased from 19.11% in 2013 to 9.94% in 2019 (P for trend < 0.001). After matching, no significant differences in the risk of of in-hospital death (odds ratio [OR], 4.00; 95% confidence interval [CI] 0.85–18.83), wound infection (OR 0.72; 95%CI 0.45–1.17), myocardial infarction (OR 1.17; 95%CI 0.62–2.19), deep vein thrombosis (OR 1.25; 95%CI 0.88–1.78), pulmonary embolism (OR 2.25; 95%CI 0.98–5.17), readmission rates (OR 1.07; 95%CI 0.88–1.30) and readmission causes were observed between two groups. However, the transfusion group had higher hospitalization charges than the non-transfusion group (72,239.89 vs 65,649.57 Chinese yuan [CNY], P < 0.001). Conclusions: This study found that allogeneic RBC transfusion in THA was not associated with the increased risk of complications and any-cause readmission. However, the currently restrictive transfusion policy should be continued because excessive blood transfusion may increase the socioeconomic burden. [ABSTRACT FROM AUTHOR]
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- 2024
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228. Interactions of Nonsteroidal Antiinflammatory Drugs and Aspirin and Risk of Cardiovascular Disease in Patients With Osteoarthritis.
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Wei, Jie, Zeng, Chao, Lane, Nancy E, Li, Xiaoxiao, Lei, Guanghua, and Zhang, Yuqing
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CARDIOVASCULAR diseases risk factors , *NAPROXEN , *CONFIDENCE intervals , *NONSTEROIDAL anti-inflammatory agents , *CARDIOVASCULAR diseases , *RISK assessment , *ASPIRIN , *OSTEOARTHRITIS , *DRUG interactions , *RESEARCH funding , *DESCRIPTIVE statistics , *LONGITUDINAL method - Abstract
Nonsteroidal antiinf lammatory drugs (NSAIDs) remain the mainstay of the pharmacologic management for relieving osteoarthritis pain, and low-dose aspirin is often prescribed to osteoarthritis patients who are at high risk of cardiovascular disease (CVD). We conducted cohort studies using data from The Health Improvement Network (THIN) database (2000–2019) to assess whether the relationship of initiation of naproxen or ibuprofen vs. initiation of other NSAIDs (excluding both naproxen and ibuprofen), respectively, to the risk of CVD was modified by coprescription of low-dose aspirin among the participants with osteoarthritis. Among participants without coprescription of aspirin, the risk of CVD was lower in naproxen initiators (10.3/1000 person-years) than in other NSAIDs initiators (13.2/1000 person-years; hazard ratio = 0.71, 95% confidence interval: 0.60, 0.85). Among participants with coprescription of aspirin, however, the risk of CVD was higher among naproxen initiators (36.9/1000 person-years) than that among other NSAIDs initiators (34.8/1000 person-years; hazard ratio = 1.48, 95% confidence interval: 1.12, 1.84). The association was significantly modified by coprescription of aspirin (P < 0.001). Similar findings were observed in the association of initiation of ibuprofen vs. other NSAIDs with the risk of CVD, which was significantly modified by coprescription of aspirin (P < 0.001). These findings suggest that osteoarthritis patients and clinicians should be aware of the potential CVD risk of concurrently taking naproxen or ibuprofen and low-dose aspirin. [ABSTRACT FROM AUTHOR]
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- 2023
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229. Lowering Serum Urate With Urate‐Lowering Therapy to Target and Incident Fracture Among People With Gout.
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Wei, Jie, Choi, Hyon K., Dalbeth, Nicola, Lane, Nancy E., Wu, Jing, Lyu, Houchen, Zeng, Chao, Lei, Guanghua, and Zhang, Yuqing
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HYPERURICEMIA , *GOUT suppressants , *CONFIDENCE intervals , *TREATMENT effectiveness , *COMPARATIVE studies , *OSTEOPOROSIS , *RANDOMIZED controlled trials , *DESCRIPTIVE statistics , *STATISTICAL sampling , *GOUT , *BONE fractures , *VERTEBRAL fractures , *DISEASE risk factors , *DISEASE complications - Abstract
Objective: Gout is associated with a higher risk of fracture; however, findings on the associations of hyperuricemia and urate‐lowering therapy (ULT) with the risk of fracture have been inconsistent. We examined whether lowering serum urate (SU) levels with ULT to a target level (i.e., <360 μmoles/liter) reduces the risk of fracture among individuals with gout. Methods: We emulated analyses of a hypothetical target trial using a "cloning, censoring, and weighting" approach to examine the association between lowering SU with ULT to the target levels and the risk of fracture using data from The Health Improvement Network, a UK primary care database. Individuals with gout who were age 40 years or older and for whom ULT was initiated were included in the study. Results: Among 28,554 people with gout, the 5‐year risk of hip fracture was 0.5% for the "achieving the target SU level" arm and 0.8% for the "not achieving the target SU level" arm. The risk difference and hazard ratio for the "achieving the target SU level" arm was –0.3% (95% confidence interval [95% CI] –0.5%, –0.1%) and 0.66 (95% CI 0.46, 0.93), respectively, compared with the "not achieving the target SU level" arm. Similar results were observed when the associations between lowering SU level with ULT to the target levels and the risk of composite fracture, major osteoporotic fracture, vertebral fracture, and nonvertebral fracture were assessed. Conclusion: In this population‐based study, lowering the SU level with ULT to the guideline‐based target level was associated with a lower risk of incident fracture in people with gout. [ABSTRACT FROM AUTHOR]
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- 2023
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230. The gut microbiome-joint axis in osteoarthritis.
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Wei, Jie, Zhang, Yuqing, Hunter, David, Zeng, Chao, and Lei, Guanghua
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OSTEOARTHRITIS - Published
- 2023
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231. Neuraxial versus general anesthesia for perioperative outcomes and resource utilization following knee arthroplasty: experience from a large national database.
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Long, Huizhong, Zeng, Chao, Xiong, Yunchuan, Shi, Ying, Wang, Haibo, and Lei, Guanghua
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GENERAL anesthesia , *DATABASES , *PROPENSITY score matching , *ARTHROPLASTY , *VENOUS thrombosis , *SURGICAL site infections - Abstract
Introduction: Attentions have been paid to the optimal anesthesia for knee arthroplasty (KA). We sought to investigate whether neuraxial anesthesia (NA) is superior to general anesthesia (GA) in terms of perioperative outcomes and resource utilization following KA. Methods: Patients undergoing primary KA registered in the Hospital Quality Monitoring System (HQMS) in China during 2013–2019 were identified. By utilizing a time-stratified propensity score matching, every patient receiving NA was matched by propensity score to a patient receiving GA. Then, we conducted Poisson, logistic, and linear regression to compare NA with GA in terms of perioperative outcomes and resource utilization. Results: Of 109,132 included participants, 75,945 (69.59%) underwent KA with GA and 33,187 (30.41%) with NA. After propensity score matching (26,425 participants per group), NA was associated with lower incidence of blood transfusion (OR: 0.82, 95% CI 0.77–0.87; p < 0.0001), 30-day readmission (OR: 0.76, 95% CI 0.68–0.84; p < 0.0001), and 90-day readmission (OR: 0.83, 95% CI 0.77–0.90; p < 0.0001). No statistically significant difference in in-hospital mortality, incidence of pulmonary embolism, deep vein thrombosis, and surgical site infection was found. In addition, NA was associated with a 1% decrease in length of stay (95% CI 0–2%; p = 0.0070) and a 3% lower total hospital charge (95% CI 2–4%; p < 0.0001) when compared with GA. Conclusion: Compared with GA, NA was associated with decreased incidence of blood transfusion, readmission, reduced length of stay, and total hospital charge following KA, suggesting the favorable role of NA for perioperative outcomes and resource utilization in KA. [ABSTRACT FROM AUTHOR]
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- 2023
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232. Comparative effectiveness of BNT162b2 and ChAdOx1 nCoV-19 vaccines against COVID-19.
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Wei, Jie, Zhang, Weiya, Doherty, Michael, Wallace, Zachary S., Sparks, Jeffrey A., Lu, Na, Li, Xiaoxiao, Zeng, Chao, Lei, Guanghua, and Zhang, Yuqing
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COVID-19 vaccines , *COVID-19 , *MEDICAL research , *MEDICAL databases , *RANDOMIZED controlled trials , *GENITAL warts - Abstract
Background: Both BNT162b2 (Pfizer–BioNTech) and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) vaccines have shown high efficacy against COVID-19 in randomized controlled trials. However, their comparative effectiveness against COVID-19 is unclear in the real world. We evaluated the comparative effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines against COVID-19 in the UK general population. Methods: We emulated a target trial using IQVIA Medical Research Database (IMRD), an electronic primary care database from the UK (2021). We included 1,311,075 participants, consisting of 637,549 men and 673,526 women age≥18 years, who received vaccination with BNT162b2 or ChAdOx1 nCoV-19 between January 1 and August 31, 2021. The outcomes consisted of confirmed diagnosis of SARS-CoV-2 infection, hospitalisation for COVID-19 and death from COVID-19 in the IMRD. We performed a cox-proportional hazard model to compare the risk of each outcome variable between the two vaccines adjusting for potential confounders with time-stratified overlap weighting of propensity score (PS). Results: During a mean of 6.7 months of follow-up, 20,070 confirmed SARS-CoV-2 infection occurred in individuals who received BNT162b2 vaccine (PS weighted incidence rate: 3.65 per 1000 person-months), and 31,611 SARS-CoV-2 infection occurred in those who received ChAdOx1 nCoV-19 vaccine (PS weighted incidence rate: 5.25 per 1000 person-months). The time-stratified PS weighted rate difference of SARS-CoV-2 infection for BNT162b2 group vs. ChAdOx1 nCoV-19 group was -1.60 per 1000 person-months (95% confidence interval [CI]: -1.76 to -1.43 per 1000 person-months), and the hazard ratio was 0.69 (95% CI: 0.68 to 0.71). The results were similar across the stratum of sex, age (<65 and ≥65 years), and study periods (i.e., alpha-variant predominance period and delta-variant predominance period). The PS weighted incidence of hospitalisation for COVID-19 was also lower in the BNT162b2 vaccine group than that in the ChAdOx1 vaccine group (RD: -0.09, 95%CI: -0.13 to -0.05 per 1000 person-months; HR: 0.65, 95%CI: 0.57 to 0.74). No significant difference in the risk of death from COVID-19 was observed between the two comparison groups. Conclusions: In this population-based study, the BNT162b2 vaccine appears to be more efficacious than the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection and hospitalisation for COVID-19 but not death from COVID-19. [ABSTRACT FROM AUTHOR]
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- 2023
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233. Diagnostic accuracy of ultrasound for the assessment of Baker’s cysts: a meta-analysis.
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Liu, Ke, Li, Xiaoxiao, Weng, Qianlin, Lei, Guanghua, and Jiang, Ting
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Background: Baker’s cyst is the most common cystic disease of the knee, and a fast and accurate diagnosis of Baker’s cyst is essential for a better management. Ultrasound is a rapid, portable, widely available, inexpensive and noninvasive imaging modality. However, the diagnostic accuracy of ultrasound on Baker’s cyst still remains undetermined. We conducted the first meta-analysis to comprehensively assess the accuracy of ultrasound for the detection of Baker’s cyst. Methods: PubMed, Embase and Web of Science were searched from inception to July 14, 2022, without language restrictions. Studies providing cross-tabulations of ultrasound versus pathology (gold standard) or MRI (standard imaging technique) for diagnosis of Baker’s cyst were included. Indicators for the diagnostic accuracy of ultrasound, including sensitivity, specificity and area under the curve, were calculated using a bivariate model. Sensitivity analysis was conducted to evaluate the heterogeneity and robustness of the results. Results: A total of 13 studies with 1,011 subjects (mean age 32.2 years; men 53.5%) met the inclusion criteria. The pooled sensitivity, specificity and area under the curve of ultrasound for diagnosis of Baker’s cyst, compared with pathology, were 0.97 (95% confidence intervals: 0.73–1.00), 1.00 (0.98–1.00) and 1.00 (0.99–1.00), respectively. The pooled estimates of ultrasound versus MRI were 0.94 (0.87–0.98) for sensitivity, 1.00 (0.83–1.00) for specificity and 0.97 (0.95–0.98) for area under the curve. Sensitivity analysis did not change the results materially. Conclusion: Ultrasound shows excellent diagnostic accuracy for the assessment of Baker’s cyst and provides similar diagnostic information (absent or present) compared to MRI. Because of its advantages of low cost, portability and accessibility, ultrasound is likely to be a choice of imaging technique for screening Baker’s cyst in clinical and population settings as well as in follow-ups. [ABSTRACT FROM AUTHOR]
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- 2022
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234. Generating real-world evidence compatible with evidence from randomized controlled trials: a novel observational study design applicable to surgical transfusion research.
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Yu, Xiaochu, Wang, Zixing, Wang, Lei, Huang, Yuguang, Wang, Yipeng, Xin, Shijie, Lei, Guanghua, Zhao, Shengxiu, Chen, Yali, Guo, Xiaobo, Han, Wei, Yu, Xuerong, Xue, Fang, Wu, Peng, Gu, Wentao, and Jiang, Jingmei
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RANDOMIZED controlled trials , *RED blood cell transfusion , *SCIENTIFIC observation , *OLDER patients , *EXPERIMENTAL design , *BLOOD transfusion - Abstract
Background: Numerous observational studies have revealed an increased risk of death and complications with transfusion, but this observation has not been confirmed in randomized controlled trials (RCTs). The "transfusion kills patients" paradox persists in real-world observational studies despite application of analytic methods such as propensity-score matching. We propose a new design to address this long-term existing issue, which if left unresolved, will be deleterious to the healthy generation of evidence that supports optimized transfusion practice. Methods: In the new design, we stress three aspects for reconciling observational studies and RCTs on transfusion safety: (1) re-definition of the study population according to a stable hemoglobin range (gray zone of transfusion decision; 7.5–9.5 g/dL in this study); (2) selection of comparison groups according to a trigger value (last hemoglobin measurement before transfusion; nadir during hospital stay for control); (3) dealing with patient heterogeneity according to standardized mean difference (SMD) values. We applied the new design to hospitalized older patients (aged ≥60 years) undergoing general surgery at four academic/teaching hospitals. Four datasets were analyzed: a base population before (Base Match−) and after (Base Match+) propensity-score matching to simulate previous observational studies; a study population before (Study Match−) and after (Study Match+) propensity-score matching to demonstrate effects of our design. Results: Of 6141 older patients, 662 (10.78%) were transfused and showed high heterogeneity compared with those not receiving transfusion, particularly regarding preoperative hemoglobin (mean: 11.0 vs. 13.5 g/dL) and intraoperative bleeding (≥500 mL: 37.9% vs. 2.1%). Patient heterogeneity was reduced with the new design; SMD of the two variables was reduced from approximately 100% (Base Match−) to 0% (Study Match+). Transfusion was related to a higher risk of death and complications in Base Match− (odds ratio [OR], 95% confidence interval [CI]: 2.68, 1.86–3.86) and Base Match+ (2.24, 1.43–3.49), but not in Study Match− (0.77, 0.32–1.86) or Study Match+ (0.66, 0.23–1.89). Conclusions: We show how choice of study population and analysis could affect real-world study findings. Our results following the new design are in accordance with relevant RCTs, highlighting its value in accelerating the pace of transfusion evidence generation and generalization. [ABSTRACT FROM AUTHOR]
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- 2022
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235. Fluorescent sensor based on CdTe-QDs @ N-CDs complexes for visual identification of goji berries origin.
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Suo, Yixin, Long, Wanjun, Qi, Linlin, Yao, Fangmi, Lei, Guanghua, Guan, Yuting, Hu, Zikang, Marchioni, Eric, Zhao, Minjie, Zhou, Li, and Fu, Haiyan
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PHENOL content of food , *PHOTOINDUCED electron transfer , *BERRIES , *QUANTUM dots , *DISCRIMINANT analysis , *PHENOLIC acids - Abstract
The price and quality of goji berries (GB) are closely linked to their origins. Therefore, identifying the geographical origins of GB produced in specific origin is important. In this work, a fluorescent sensor based on a glutathione modified quantum dots and nitrogen-doped carbon quantum dots complexes (CdTe-QDs @ N-CDs) with an internal filtration effect (IFE) was constructed to visual identify the origin of GB. The phenolic acid compounds in GB could quench the fluorescence of QDs and CDs through the photoinduced electron transfer (PET) and the aggregation-induced quenching (ACQ), respectively. Due to the different contents of phenolic acid in GB from different origins, the fluorescent sensor based on CdTe-QDs @ N-CDs complexes could produce distinct and different fluorescent colors, from orange to blue under the dual reaction. Finally, partial least squares discriminant analysis (PLS-DA) model was applied to establish classification models for identifying the geographical origin of GB based on the fluorescent colors. The results showed that the accuracy of GB visual recognition could be increased from 68.9% to 93.3%. This proven that the proposed strategy has excellent potentials for identification of the geographical origins of GB. [Display omitted] • A novel visual fluorescent sensing method was constructed for identified GB origins. • CdTe-QDs@N-CDs enables visual identification of GB origin through PET & ACQ effects. • The accuracy of GB origin identification based on RGB data was 93.3%. [ABSTRACT FROM AUTHOR]
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- 2024
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236. Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study.
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He, Hongyi, Wang, Yilun, Yang, Zidan, Ding, Xiang, Yang, Tuo, Lei, Guanghua, Li, Hui, and Xie, Dongxing
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CHONDROCALCINOSIS , *ZINC , *COPPER , *GENERALIZED estimating equations , *KNEE - Abstract
Background: Patients with chondrocalcinosis may suffer from a series of symptoms resembling acute gouty arthritis or septic arthritis, but the aetiology and pathogenesis of chondrocalcinosis have not been fully elucidated yet. This study was aimed to assess serum zinc and copper concentrations, as well as the ratio of serum copper to zinc concentrations (Cu/Zn ratio), in relation to the prevalence of knee chondrocalcinosis.Methods: Data included in this analysis were retrieved from a large population-based cross-sectional study. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was diagnosed if definite linear cartilage calcification was detected. Serum zinc and copper concentrations were measured using the spectrophotometric flow injection methods by Roche modular P800. The relations of serum zinc and copper concentrations and Cu/Zn ratio to the prevalence of knee chondrocalcinosis were examined using generalized estimating equations, respectively.Results: The prevalence of knee chondrocalcinosis was 1.2% in the sample of this study (n = 12,362). In comparison with the lowest tertile, the odds ratios (ORs) of knee chondrocalcinosis adjusted by age, sex and body mass index were 0.74 (95% CI 0.50-1.09) in the second and 0.56 (95% CI 0.36-0.86) in the third tertiles of serum zinc concentrations (P for trend = 0.009), were 1.26 (95% CI 0.77-2.05) in the second and 2.01 (95% CI 1.25-3.24) in the third tertile of serum copper concentrations (P for trend = 0.003), and were 1.02 (95% CI 0.61-1.69) in the second and 2.23 (95% CI 1.38-3.59) in the third tertile of Cu/Zn ratio (P for trend < 0.001) respectively. These findings were not materially altered by adjustment for potential confounders.Conclusions: The present study observed that higher serum zinc concentrations, lower serum copper concentrations or lower Cu/Zn ratio are associated with a lower prevalence of knee chondrocalcinosis in a dose-response relationship manner. [ABSTRACT FROM AUTHOR]- Published
- 2020
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237. A sensitive fluorescence sensor based on a glutathione modified quantum dot for visual detection of copper ions in real samples.
- Author
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Hu, Zikang, Long, Wanjun, Liu, Tingkai, Guan, Yuting, Lei, Guanghua, Suo, Yixin, Jia, Mengguo, He, Jieling, Chen, Hengye, She, Yuanbin, and Fu, Haiyan
- Subjects
- *
QUANTUM dots , *COPPER ions , *FLUORESCENCE , *GLUTATHIONE , *CHINESE medicine , *DETECTORS - Abstract
[Display omitted] • A fluorescence sensor based on aggregation-caused quenching was designed. • The sensor exhibited sensitive and rapid detection to Cu2+ residues. • Colorimetric detection of Cu2+ is realized by capturing the change of fluorescence color. • This method has good application in quantifying Cu2+ in actual samples. Copper (Cu2+), as a heavy metal, accumulates in the human body to a certain extent, which can induce various diseases and endanger human health. Rapid and sensitive detection of Cu2+ is highly desired. In present work, a glutathione modified quantum dot (GSH-CdTe QDs) was synthesized and applied in a "turn-off" fluorescence probe to detect Cu2+. The fluorescence of GSH-CdTe QDs could be rapidly quenched in the presence of Cu2+ through aggregation-caused quenching (ACQ), resulting from the interaction between the surface functional groups of GSH-CdTe QDs and Cu2+ and the electrostatic attraction. In the range of 20–1100 nM, the Cu2+ concentration showed a good linear relationship with the fluorescence decline of the sensor, and the LOD is 10.12 nM, which was lower than the U.S. Environmental Protection Agency (EPA) defined limit (20 μM). Moreover, aiming to attain visual analysis, colorimetric method was also used for rapidly detecting Cu2+ by capturing the change in fluorescence color. Interestingly, the proposed approach has successfully been applied for the detection of Cu2+ in real samples (i.e., environment water, food and traditional Chinese medicine) with satisfactory results, which provides a promising strategy for the detection of Cu2+ in practical application with the merits of being rapid, simple and sensitive. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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238. Construction and evaluation of networks among multiple postoperative complications.
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Shen, Yubing, Zhang, Luwen, Wu, Peng, Huang, Yuguang, Xin, Shijie, Zhang, Qiang, Zhao, Shengxiu, Sun, Hong, Lei, Guanghua, Zhang, Taiping, Han, Wei, Wang, Zixing, Jiang, Jingmei, and Yu, Xiaochu
- Subjects
- *
SURGICAL complications , *CLINICAL decision support systems , *BAYESIAN analysis , *BAYES' theorem , *LENGTH of stay in hospitals , *DEEP brain stimulation , *AUTOMATED external defibrillation - Abstract
• The present network visualized the complex associations among multiple complications. • Our new grading approach can classify complication severity using the items. • Quantified associations among complications included cascade, cluster, and synergy. • Updating probability with new information supports prevention and clinical decision. Postoperative complications confer an increased risk of reoperation, prolonged length of hospital stay, and increased mortality. Many studies have attempted to identify the complex associations among complications to preemptively interrupt their progression, but few studies have looked at complications as a whole to reveal and quantify their possible trajectories of progression. The main objective of this study was to construct and quantify the association network among multiple postoperative complications from a comprehensive perspective to elucidate the possible evolution trajectories. In this study, a Bayesian network model was proposed to analyze the associations among 15 complications. Prior evidence and score-based hill-climbing algorithms were used to build the structure. The severity of complications was graded according to their connection to death, with the association between them quantified using conditional probabilities. The data of surgical inpatients used in this study were collected from four regionally representative academic/teaching hospitals in a prospective cohort study in China. In the network obtained, 15 nodes represented complications or death, and 35 arcs with arrows represented the directly dependent relationship between them. With three grades classified on that basis, the correlation coefficients of complications within grades increased with increased grade, ranging from −0.11 to −0.06, 0.16, and 0.21 to 0.4 in grade 1 to grade 3, respectively. Moreover, the probability of each complication in the network increased with the occurrence of any other complication, even mild complications. Most seriously, once cardiac arrest requiring cardiopulmonary resuscitation occurs, the probability of death will be up to 88.1%. The present evolving network can facilitate the identification of strong associations among specific complications and provides a basis for the development of targeted measures to prevent further deterioration in high-risk patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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239. Rapid identification of the geographical origin of Eucommia ulmoides by using excitation-emission matrix fluorescence combined with chemometric methods.
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Liu, Tingkai, Long, Wanjun, Hu, Zikang, Guan, Yuting, Lei, Guanghua, He, Jieling, Yang, Xiaolong, Yang, Jian, and Fu, Haiyan
- Subjects
- *
EUCOMMIA ulmoides , *FLUORESCENCE , *CHINESE medicine , *CHEMOMETRICS , *K-nearest neighbor classification , *INTRAMOLECULAR proton transfer reactions - Abstract
[Display omitted] • EEM fluorescence combined with chemometrics was proposed for rapid identification the origin of Eucommia ulmoides for the first time. • PARAFAC were used for spectral characterization. • Classification model for the identification the geographical origin was established by kNN, PCA-LDA and PLS-DA. • Compared to other models, kNN model achieved satisfactory results. Eucommia ulmoides is an important and valuable traditional Chinese medicine with various medical functions, and has been widely used as health food in China, Japan, South Korea and other Asian countries for many years. The efficacy and quality of E. ulmoides are closely associated with the geographical origin. In this work, the potential of excitation-emission matrix (EEMs) fluorescence coupled with chemometric methods was investigated for simple, rapid and accurate for identification E. ulmoides from different geographical origins. Parallel factor analysis (PARAFAC) was applied for characterizing the fluorescence fingerprints of E. ulmoides samples. Moreover, k-nearest neighbor (kNN), principal component analysis-linear discriminant analysis (PCA-LDA) and partial least squares discriminant analysis (PLS-DA) models were used for the classification of E. ulmoides samples according to their geographical origins. The results showed that kNN model was more suitable for identification of E. ulmoides samples from different provinces. The kNN model could identify E. ulmoides samples from eight different geographical origins with 100% accuracy on the training and test sets. Therefore, the proposed method was available for conveniently and accurately determining the geographical origin of E. ulmoides , which can expect to be an attractive alternative method for identifying the geographic origin of other traditional Chinese medicines. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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240. Using MgO nanoparticles as a potential platform to precisely load and steadily release Ag ions for enhanced osteogenesis and bacterial killing.
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Yang, Si, Liang, Luxin, Liu, Ling, Yin, Yong, Liu, Yong, Lei, Guanghua, Zhou, Kun, Huang, Qianli, and Wu, Hong
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NANOPARTICLES , *MAGNESIUM oxide , *BONE regeneration , *METALLIC composites , *ALKALINE phosphatase , *BONES , *BACTERICIDAL action , *BONE growth - Abstract
Bio-functional fillers including bio-ceramic, degradable metallic and composite particles are commonly introduced into bone tissue engineering (BTE) scaffolds to endow the materials with specific biological functions for enhanced bone defect therapy. In this work, MgO nanoparticles (NPs) were employed as a potential platform for precise loading and sustained release of Ag+. The results showed that MgO NPs possessed strong adsorption capacity (almost 100%) towards Ag+ in AgNO 3 solutions with different concentrations (0.1, 1 and 10 mM). After the adsorption of Ag+ in AgNO 3 solutions, cube-shaped MgO NPs transformed to lamella-structured nano-composites (NCs) composed of Mg(OH) 2 and Ag 2 O, which were referred as MgO-xAg (x = 0.1, 1 or 10) NCs depending on the employed concentration of AgNO 3 solution. After being suspended in distilled water, as-prepared positively charged NCs underwent a fast degradation process during the initial 4 days. From day 4 and 14, steady release behaviors of Mg2+ and/or Ag+ from the NCs were noticed. With the lowest loading amount of Ag+, MgO-0.1Ag NCs did not exhibit significant modulatory effect on SaOS-2 cell response. On the contrary, MgO-10Ag NCs loaded with the highest amount of Ag+ showed significant cyto-toxicity towards SaOS-2 cells. With appropriate amount of Ag+ loading, MgO-1Ag NCs showed significantly stimulatory effects on SaOS-2 cell proliferation and differentiation. This is evidenced by the enhanced cell viability, alkaline phosphatase (ALP) activity and collagen (COL) production as well as the gene expressions of ALP, COL and osteoprotegerin (OPG) in MgO-1Ag group. Moreover, MgO-1Ag exhibited strong bactericidal capacity against both Escherichia coli and Staphylococcus aureus. Together, the results indicate that MgO could be employed as a potential platform for precise loading and sustained release of Ag+. MgO-1Ag NCs are promising to be used as bio-functional fillers in BTE scaffolds for simultaneously promoted osteogenesis and bacterial killing. • Mg(OH) 2 /Ag 2 O NCs were prepared by precise loading of Ag+ on MgO NPs. • Mg(OH) 2 /Ag 2 O NCs exhibited a sustained release mode of Ag+. • The MgO-1Ag group enhanced both osteoblast differentiation and bacterial killing. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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241. Association between proton pump inhibitors use and risk of hip fracture: A general population-based cohort study.
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Wei, Jie, Chan, Andrew T., Zeng, Chao, Bai, Xiaochun, Lu, Na, Lei, Guanghua, and Zhang, Yuqing
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- *
HIP fractures , *PROTON pump inhibitors , *ANTIHISTAMINES , *COHORT analysis , *ODDS ratio - Abstract
Previous studies comparing risk of fracture among Proton Pump Inhibitors (PPIs) users with that among non-users were susceptible to confounding by indication. Epidemiologic studies of this association using an active medication as a comparator would appropriately address this bias. We conducted a propensity-score matched cohort study to compare the risk of incident fracture over five years among initiators of PPIs with initiators of histamine 2 receptor antagonist (H2RA) using data collected from The Health Improvement Network (THIN) database in the United Kingdom (2000–2016). The prevalence of PPIs prescription increased 3.8-fold from 2000 (7.9%) to 2012 (30.3%) and remained stable since then. Of the 50,265 propensity-score matched participants in each cohort (mean age was 65 years, and 57% were women), 370 (1.9/1000 person-years) incident hip fracture occurred in the PPIs initiators and 294 (1.5/1000 person-years) in the H2RA initiators during the follow-up period. The rate difference of incident hip fracture for PPIs initiation was 0.4 (95% confidence interval [CI]: 0.2–0.7)/1000 person-years compared with H2RA initiation and the corresponding hazard ratio (HR) was 1.27 (95%CI: 1.09–1.48). Compared with non-PPI use, multivariable-adjusted odds ratios (ORs) of hip fracture were 1.17 (95%CI: 0.94–1.46), 1.55 (95%CI: 1.23–1.96), and 1.67 (95%CI: 1.33–2.10) for 1–2, 3–9 and ≥ 10 prescriptions of PPIs, respectively (P for trend = 0.001). We found that PPIs prescription has been increasing rapidly over the past decade in the United Kingdom, and the initiation of PPIs was associated with a higher risk of hip fracture than initiation of H2RA. • No study has been conducted to compare the risk of fracture among PPI initiators with that among an active comparator. • Number of PPIs prescriptions for subjects aged 50 years and older had been increasing significantly over the past decade. • Initiation of PPIs was associated with a higher risk of hip fracture than initiation of a similarly medication, H2RA. • Our findings were independent of major confounding factors and were consistent in several sensitivity analyses. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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242. Association of Regular Opioid Use With Incident Dementia and Neuroimaging Markers of Brain Health in Chronic Pain Patients: Analysis of UK Biobank.
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Gao Y, Su B, Ding L, Qureshi D, Hong S, Wei J, Zeng C, Lei G, and Xie J
- Subjects
- Humans, Male, Female, United Kingdom epidemiology, Middle Aged, Case-Control Studies, Aged, Cross-Sectional Studies, Prospective Studies, Brain diagnostic imaging, Brain drug effects, Biological Specimen Banks, Magnetic Resonance Imaging, UK Biobank, Chronic Pain drug therapy, Chronic Pain epidemiology, Dementia epidemiology, Analgesics, Opioid therapeutic use, Neuroimaging
- Abstract
Objectives: We aimed to investigate the association of regular opioid use, compared with non-opioid analgesics, with incident dementia and neuroimaging outcomes among chronic pain patients., Design: The primary design is a prospective cohort study. To triangulate evidence, we also conducted a nested case-control study analyzing opioid prescriptions and a cross-sectional study analyzing neuroimaging outcomes., Setting and Participants: Dementia-free UK Biobank participants with chronic pain and regular analgesic use., Measurements: Chronic pain status and regular analgesic use were captured using self-reported questionnaires and verbal interviews. Opioid prescription data were obtained from primary care records. Dementia cases were ascertained using primary care, hospital, and death registry records. Propensity score-matched Cox proportional hazards analysis, conditional logistic regression, and linear regression were applied to the data in the prospective cohort, nested case-control, and cross-sectional studies, respectively., Results: Prospective analyses revealed that regular opioid use, compared with non-opioid analgesics, was associated with an increased dementia risk over the 15-year follow-up (Hazard ratio [HR], 1.18 [95% confidence interval (CI): 1.08-1.30]; Absolute rate difference [ARD], 0.44 [95% CI: 0.19-0.71] per 1000 person-years; Wald χ
2 = 3.65; df = 1; p <0.001). The nested case-control study suggested that a higher number of opioid prescriptions was associated with an increased risk of dementia (1 to 5 prescriptions: OR = 1.21, 95% CI: 1.07-1.37, Wald χ2 = 3.02, df = 1, p = 0.003; 6 to 20: OR = 1.27, 95% CI: 1.08-1.50, Wald χ2 = 2.93, df = 1, p = 0.003; more than 20: OR = 1.43, 95% CI: 1.23-1.67, Wald χ2 = 4.57, df = 1, p < 0.001). Finally, neuroimaging analyses revealed that regular opioid use was associated with lower total grey matter and hippocampal volumes, and higher white matter hyperintensities volumes., Conclusion: Regular opioid use in chronic pain patients was associated with an increased risk of dementia and poorer brain health when compared to non-opioid analgesic use. These findings imply a need for re-evaluation of opioid prescription practices for chronic pain patients and, if further evidence supports causality, provide insights into strategies to mitigate the burden of dementia., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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243. The mediation effects of malalignment on the relation of sex to the risk of incidence tibiofemoral osteoarthritis.
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Xin H, Li X, Zhang Y, Zeng C, Lei G, Yang T, and Wei J
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- Humans, Male, Female, Aged, Middle Aged, Incidence, Sex Factors, Risk Factors, Knee Joint diagnostic imaging, Knee Joint physiopathology, Tibia diagnostic imaging, Osteoarthritis, Knee epidemiology, Bone Malalignment epidemiology, Bone Malalignment complications, Bone Malalignment diagnostic imaging, Radiography
- Abstract
Objective: To investigate to what extent the higher risk of tibiofemoral radiographic osteoarthritis (TFROA) in females vs. males can be explained by knee malalignment., Design: Using data from Multicenter Osteoarthritis Study (MOST) and Osteoarthritis Initiative (OAI), we examined the relation of sex to the incident medial and lateral TFROA and performed mediation analyses to assess to what extent varus and valgus malalignments account for sex differences in the incident medial or lateral TFROA., Results: Of the 3462 knees without medial and lateral TFROA in MOST, the 7-year risks of medial and lateral TFROA were 16.9% and 10.0% in females, and 15.8% and 4.2% in males, respectively. Females had 2.31-fold (95% confidence interval [95% CI]: 1.73 to 3.08) higher incident lateral TFROA than males, and the relative risk (RR) of the indirect effect of sex on lateral TFROA through valgus malalignment was 1.15 (95% CI: 1.09 to 1.20), accounting for 23% of its total effect on lateral TFROA. In OAI (n = 3095 knees), females had 1.54-fold (95% CI: 1.15 to 2.04) higher incident lateral TFROA than males, and RR of the indirect effect of sex on lateral TFROA through valgus malalignment was 1.10 (95% CI: 1.04 to 1.21), accounting for 26% of its total effect on lateral TFROA. No apparent sex difference in the incident medial TFROA was found in MOST (RR = 1.05, 95% CI: 0.89 to 1.25) or OAI (RR = 1.02, 95% CI: 0.84 to 1.19)., Conclusion: Females had a higher risk of developing lateral TFROA than males; however, valgus malalignment only modestly explained such a difference., Competing Interests: Declaration of Competing Interest The authors declare no competing interest., (Copyright © 2024 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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244. Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis.
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Jiang T, Weng Q, Zhang Y, Zhang W, Doherty M, Sarmanova A, Yang Z, Yang T, Li J, Liu K, Wang Y, Obotiba AD, Zeng C, Lei G, and Wei J
- Subjects
- Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Aged, Prevalence, China epidemiology, Hand Joints diagnostic imaging, Adult, Ultrasonography, Doppler, Risk Factors, Uric Acid blood, Hyperuricemia epidemiology, Hyperuricemia blood, Synovitis diagnostic imaging, Synovitis epidemiology
- Abstract
Objective: Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population-based sample., Methods: We performed a cross-sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate level >420 μmol/L in men and >360 μmol/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both gray-scale synovitis and the Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0-3). We evaluated the association of hyperuricemia with hand gray-scale synovitis (grade ≥2) and PDS (grade ≥1), respectively, adjusting for age, sex, and body mass index., Results: All required assessments for analysis were available for 3,286 participants. The prevalence of hand gray-scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI] 1.00-1.62). Participants with hyperuricemia also had a higher prevalence of PDS (aOR 2.36; 95% CI 1.15-4.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with the presence of gray-scale synovitis (aOR 1.27; 95% CI 1.00-1.60 and adjusted prevalence ratio [aPR] 1.26; 95% CI 1.10-1.44, respectively) and PDS (aOR 2.35; 95% CI 1.15-4.79 and aPR 2.34; 95% CI 1.28-4.30, respectively)., Conclusion: This population-based study provides more evidence for a positive association between hyperuricemia and prevalent hand synovitis., (© 2024 American College of Rheumatology.)
- Published
- 2024
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245. Mechanical protein polycystin-1 directly regulates osteoclastogenesis and bone resorption.
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Huang M, Zhou J, Li X, Liu R, Jiang Y, Chen K, Jiao Y, Yin X, Liu L, Sun Y, Wang W, Xiao Y, Su T, Guo Q, Huang Y, Yang M, Wei J, Darryl Quarles L, Xiao Z, Zeng C, Luo X, Lei G, and Li C
- Subjects
- Animals, Mice, Humans, Osteoporosis genetics, Osteoporosis metabolism, Osteoporosis pathology, Polycystic Kidney, Autosomal Dominant genetics, Polycystic Kidney, Autosomal Dominant metabolism, Polycystic Kidney, Autosomal Dominant pathology, Male, Female, Adaptor Proteins, Signal Transducing, TRPP Cation Channels genetics, TRPP Cation Channels metabolism, Bone Resorption metabolism, Bone Resorption genetics, Bone Resorption pathology, Osteoclasts metabolism, Osteogenesis, Mice, Knockout
- Abstract
Mechanical loading is required for bone homeostasis, but the underlying mechanism is still unclear. Our previous studies revealed that the mechanical protein polycystin-1 (PC1, encoded by Pkd1) is critical for bone formation. However, the role of PC1 in bone resorption is unknown. Here, we found that PC1 directly regulates osteoclastogenesis and bone resorption. The conditional deletion of Pkd1 in the osteoclast lineage resulted in a reduced number of osteoclasts, decreased bone resorption, and increased bone mass. A cohort study of 32,500 patients further revealed that autosomal dominant polycystic kidney disease, which is mainly caused by loss-of-function mutation of the PKD1 gene, is associated with a lower risk of hip fracture than those with other chronic kidney diseases. Moreover, mice with osteoclast-specific knockout of Pkd1 showed complete resistance to unloading-induced bone loss. A mechanistic study revealed that PC1 facilitated TAZ nuclear translocation via the C-terminal tail-TAZ complex and that conditional deletion of Taz in the osteoclast lineage resulted in reduced osteoclastogenesis and increased bone mass. Pharmacological regulation of the PC1-TAZ axis alleviated unloading- and estrogen deficiency- induced bone loss. Thus, the PC1-TAZ axis may be a potential therapeutic target for osteoclast-related osteoporosis., (Copyright © 2024 Science China Press. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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246. Global burden of early-onset osteoarthritis, 1990-2019: results from the Global Burden of Disease Study 2019.
- Author
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Weng Q, Chen Q, Jiang T, Zhang Y, Zhang W, Doherty M, Xie J, Liu K, Li J, Yang T, Wei J, Lei G, and Zeng C
- Subjects
- Humans, Middle Aged, Male, Female, Prevalence, Adult, Incidence, Cost of Illness, Young Adult, Obesity epidemiology, Obesity economics, Disability-Adjusted Life Years trends, Global Burden of Disease trends, Osteoarthritis epidemiology, Osteoarthritis economics, Age of Onset, Body Mass Index, Global Health economics
- Abstract
Objectives: Early-onset osteoarthritis (OA) is an emerging health issue amidst the escalating prevalence of overweight and obesity. However, there are scant data on its disease, economic burden and attributable burden due to high body mass index (BMI)., Methods: Using data from the Global Burden of Diseases Study 2019, we examined the numbers of incident cases, prevalent cases, years lived with disability (YLDs) and corresponding age-standardised rates for early-onset OA (diagnosis before age 55) from 1990 to 2019. The case definition was symptomatic and radiographically confirmed OA in any joint. The average annual percentage changes (AAPCs) of the age-standardised rates were calculated to quantify changes. We estimated the economic burden of early-onset OA and attributable burden to high BMI., Results: From 1990 to 2019, the global incident cases, prevalent cases and YLDs of early-onset OA were doubled. 52.31% of incident OA cases in 2019 were under 55 years. The age-standardised rates of incidence, prevalence and YLDs increased globally and for countries in all Sociodemographic Index (SDI) quintiles (all AAPCs>0, p<0.05), with the fastest increases in low-middle SDI countries. 98.04% of countries exhibited increasing trends in all age-standardised rates. Early-onset OA accounts for US$46.17 billion in healthcare expenditure and US$60.70 billion in productivity loss cost in 2019. The attributable proportion of high BMI for early-onset OA increased globally from 9.41% (1990) to 15.29% (2019)., Conclusions: Early-onset OA is a developing global health problem, causing substantial economic costs in most countries. Targeted implementation of cost-effective policies and preventive intervention is required to address the growing health challenge., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.)
- Published
- 2024
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247. Correction: Prevalence and distribution of ultrasound-detected hand synovial abnormalities in a middle-aged and older population.
- Author
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Jiang T, Yang T, Zhang W, Doherty M, Zhang Y, Zeng C, Sarmanova A, Yang Z, Li J, Wang Y, Wang Y, Obotiba AD, Lei G, and Wei J
- Abstract
Competing Interests: The authors declare that they have no conflict of interest.
- Published
- 2024
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248. Prevalence and distribution of ultrasound-detected hand synovial abnormalities in a middle-aged and older population.
- Author
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Jiang T, Yang T, Zhang W, Doherty M, Zhang Y, Zeng C, Sarmanova A, Yang Z, Li J, Wang Y, Wang Y, Obotiba AD, Lei G, and Wei J
- Subjects
- Humans, Female, Male, Aged, Middle Aged, China epidemiology, Hypertrophy diagnostic imaging, Ultrasonography, Doppler, Ultrasonography methods, Finger Joint diagnostic imaging, Hand Joints diagnostic imaging, Aged, 80 and over, Cross-Sectional Studies, Prevalence, Synovial Membrane diagnostic imaging, Synovial Membrane pathology, Osteoarthritis diagnostic imaging, Osteoarthritis epidemiology
- Abstract
Objective: Synovial abnormalities are modifiable targets for hand pain and osteoarthritis. We examined the prevalence and distribution of ultrasound-detected hand synovial abnormalities in a community-derived sample of older people in China., Methods: Within the Xiangya Osteoarthritis Study, a community-based study, we assessed synovial hypertrophy (SH), joint effusion, and Power Doppler signal (PDS) on all fingers and thumbs of both hands using standardized ultrasound examinations (score: 0-3). We assessed distribution patterns of SH and effusion using χ2-test and interrelationships of SH and effusion in different joints and hands by generalized estimating equations., Results: Among 3,623 participants (mean age: 64.4 years; women: 58.1%), prevalence of SH, effusion and PDS were 85.5%, 87.3% and 1.5%, respectively. Prevalence of SH, effusion and PDS increased with age, was higher in the right hand than in the left hand and was more common in proximal than in distal hand joints. SH and effusion often occurred in multiple joints (P < 0.001). SH in one joint was strongly associated with presence of SH in the same joint of the opposite hand (odds ratio [OR]= 6.60, 95% confidence interval [CI]: 6.19-7.03) followed by SH in other joints in the same row, (OR=5.70, 95%CI: 5.32-6.11), and then other joints in the same ray of the same hand (OR=1.49, 95%CI: 1.39-1.60). Similar patterns were observed for effusion., Conclusion: Hand synovial abnormalities are common among older people, often affect multiple hand joints and present a unique pattern. These findings suggest both systemic and mechanical factors play roles in their occurrence., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)
- Published
- 2024
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249. Trends and benefits of early hip arthroplasty for femoral neck fracture in China: a national cohort study.
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Wang Y, Jiang Q, Long H, Chen H, Wei J, Li X, Wang H, Xie D, Zeng C, and Lei G
- Subjects
- Humans, Retrospective Studies, Cohort Studies, Hospital Mortality, Arthroplasty, Replacement, Hip adverse effects, Pulmonary Embolism, Femoral Neck Fractures surgery
- Abstract
Background: Limited studies have examined the benefits of early arthroplasty within 48 h from admission to surgery for femoral neck fractures (FNFs). Using the national inpatient database, the authors aimed to investigate the trends in early arthroplasty within 48 h for FNFs in China and to assess its effect on in-hospital complications and 30-day readmission patterns., Materials and Methods: This was a retrospective cohort study. Patients receiving primary total hip arthroplasty (THA) or hemiarthroplasty (HA) for FNFs in the Hospital Quality Monitoring System between 2013 and 2019 were included. After adjusting for potential confounders with propensity score matching, a logistic regression model was performed to compare the differences in in-hospital complications [i.e. in-hospital death, pulmonary embolism, deep vein thrombosis (DVT), wound infection, and blood transfusion], rates and causes of 30-day readmission between early and delayed arthroplasty., Results: During the study period, the rate of early THA increased from 18.0 to 19.9%, and the rate of early HA increased from 14.7 to 18.4% ( P <0.001). After matching, 11 731 pairs receiving THA and 13 568 pairs receiving HA were included. Compared with delayed THA, early THA was associated with a lower risk of pulmonary embolism [odds ratio (OR) 0.51, 95% CI: 0.30-0.88], DVT (OR 0.59, 95% CI: 0.50-0.70), blood transfusion (OR 0.62, 95% CI: 0.55-0.70), 30-day readmission (OR 0.82, 95% CI: 0.70-0.95), and venous thromboembolism-related readmission (OR 0.50, 95% CI: 0.34-0.74). Similarly, early HA was associated with a lower risk of DVT (OR 0.70, 95% CI: 0.61-0.80) and blood transfusion (OR 0.74, 95% CI: 0.68-0.81) than delayed HA., Conclusion: Despite a slight increase, the rate of early arthroplasty remained at a low level in China. Given that early arthroplasty can significantly improve prognosis, more efforts are needed to optimize the procedure and shorten the time to surgery., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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250. Diagnostic Accuracy of Ultrasound for Assessment of Synovial Abnormalities Among Patients With Knee Pain: A Meta-Analysis.
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Liu K, Li X, Weng Q, Wang Y, Wei J, Zeng C, Lei G, and Jiang T
- Subjects
- Adult, Humans, Ultrasonography, Magnetic Resonance Imaging, Pain pathology, Knee Joint diagnostic imaging, Knee Joint pathology, Synovitis diagnostic imaging
- Abstract
Objective: Synovial abnormalities, which are modifiable treatment targets for knee pain, affect ~25% of adults. Ultrasound is a safe, inexpensive, and easily accessible imaging modality for assessing synovial abnormalities, but its diagnostic accuracy is still controversial. We conducted a meta-analysis by comparing ultrasound with the "reference standard" method, ie, magnetic resonance imaging (MRI), in assessing synovial abnormalities among patients with knee pain., Methods: PubMed, Embase, and Web of Science were searched from inception to January 7, 2022, to retrieve studies including patients with knee pain for evaluating 1) the diagnostic accuracy of ultrasound versus MRI for synovial abnormalities (synovitis and synovial effusion) and 2) the correlations of synovial abnormalities assessed by ultrasound and MRI. The summary of diagnostic accuracy was analyzed using the bivariate model, and the correlation coefficients were pooled using the random effects model., Results: Fourteen studies were included, representing a total of 755 patients. The pooled sensitivity, specificity, and area under the curve were 0.88 (95% confidence interval [95% CI] 0.65-0.96), 0.70 (95% CI 0.51-0.84), and 0.81 (95% CI 0.77-0.84) for synovitis and 0.90 (95% CI 0.81-0.95), 0.86 (95% CI 0.77-0.92), and 0.94 (95% CI 0.91-0.96) for synovial effusion, respectively. Strong correlations between ultrasound- and MRI-diagnosed synovitis (r = 0.64, 95% CI 0.56-0.71) and synovial effusion (r = 0.63, 95% CI 0.52-0.73) were observed., Conclusion: Ultrasound demonstrated a promising accuracy in detecting synovial abnormalities among patients with knee pain. The use of ultrasound provides equivalent synovial information to MRI but is less expensive and more accessible. Therefore, it is recommended as an adjuvant for managing patients with knee pain during diagnostic strategy and individualized treatment decision-making., (© 2023 American College of Rheumatology.)
- Published
- 2024
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