Search

Your search keyword '"Leeuw, Frank‐Erik"' showing total 1,348 results
Start Over Author "Leeuw, Frank‐Erik"
1,348 results on '"Leeuw, Frank‐Erik"'

202. Temporal Dynamics of Cortical Microinfarcts in Cerebral Small Vessel Disease

Author

Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Baskaran, Brendon Sri, Marques, José P, Kuijf, Hugo J, Norris, David G, Tuladhar, Anil M, Duering, Marco, de Leeuw, Frank-Erik, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Baskaran, Brendon Sri, Marques, José P, Kuijf, Hugo J, Norris, David G, Tuladhar, Anil M, Duering, Marco, and de Leeuw, Frank-Erik

Published
2020

203. Temporal Dynamics of Cortical Microinfarcts in Cerebral Small Vessel Disease

Author

Beeldverwerking ISI, Brain, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Baskaran, Brendon Sri, Marques, José P, Kuijf, Hugo J, Norris, David G, Tuladhar, Anil M, Duering, Marco, de Leeuw, Frank-Erik, Beeldverwerking ISI, Brain, Ter Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Baskaran, Brendon Sri, Marques, José P, Kuijf, Hugo J, Norris, David G, Tuladhar, Anil M, Duering, Marco, and de Leeuw, Frank-Erik

Published
2020

213. Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life.

Author

Jansen, Michelle G, Griffanti, Ludovica, Mackay, Clare E, Anatürk, Melis, Melazzini, Luca, Lange, Ann-Marie G de, Filippini, Nicola, Zsoldos, Enikő, Wiegertjes, Kim, Leeuw, Frank-Erik de, Singh-Manoux, Archana, Kivimäki, Mika, Ebmeier, Klaus P, and Suri, Sana

Abstract

We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories of vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from the Whitehall II Imaging Sub-study with multi-modal MRI (mean age 69.96, SD = 5.18, 79% men). We used linear mixed-effects models to investigate associations of SVD burden with up to 25-year retrospective trajectories of vascular risk and cognitive performance. General linear modelling was used to investigate concurrent associations with grey matter (GM) density and white matter (WM) microstructure, and whether these associations were modified by cognitive status (Montreal Cognitive Asessment [MoCA] scores of < 26 vs. ≥ 26). Severe SVD burden in older age was associated with higher mean arterial pressure throughout midlife (β = 3.36, 95% CI [0.42-6.30]), and faster cognitive decline in letter fluency (β = −0.07, 95% CI [−0.13–−0.01]), and verbal reasoning (β = −0.05, 95% CI [−0.11–−0.001]). Moreover, SVD burden was related to lower GM volumes in 9.7% of total GM, and widespread WM microstructural decline (FWE-corrected p < 0.05). The latter association was most pronounced in individuals who demonstrated cognitive impairments on MoCA (MoCA < 26; F3,608 = 2.14, p = 0.007). These findings highlight the importance of managing midlife vascular health to preserve brain structure and cognitive function in old age. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

215. Demographic and Geographic Vascular Risk Factor Differences in European Young Adults With Ischemic Stroke: The 15 Cities Young Stroke Study

Author

Putaala, Jukka, Yesilot, Nilufer, Waje-Andreassen, Ulrike, Pitkäniemi, Janne, Vassilopoulou, Sofia, Nardi, Katiuscia, Odier, Celine, Hofgart, Gergely, Engelter, Stefan, Burow, Annika, Mihalka, Laszlo, Kloss, Manja, Ferrari, Julia, Lemmens, Robin, Coban, Oguzhan, Haapaniemi, Elena, Maaijwee, Noortje, Rutten-Jacobs, Loes, Bersano, Anna, Cereda, Carlo, Baron, Pierluigi, Borellini, Linda, Valcarenghi, Caterina, Thomassen, Lars, Grau, Armin J., Palm, Frederick, Urbanek, Christian, Tuncay, Rezzan, Durukan-Tolvanen, Aysan, van Dijk, Ewoud J., de Leeuw, Frank-Erik, Thijs, Vincent, Greisenegger, Stefan, Vemmos, Konstantinos, Lichy, Christoph, Bereczki, Daniel, Csiba, Laszlo, Michel, Patrik, Leys, Didier, Spengos, Konstantinos, Naess, Halvor, Bahar, Sara Zarko, and Tatlisumak, Turgut

Published
2012
Full Text
View/download PDF

219. Routine Use of the Confusion Assessment Method for the Intensive Care Unit: A Multicenter Study

Author

van Eijk, Maarten M., van den Boogaard, Mark, van Marum, Rob J., Benner, Paul, Eikelenboom, Piet, Honing, Marina L., van der Hoven, Ben, Horn, Janneke, Izaks, Gerbrand J., Kalf, Annette, Karakus, Attila, Klijn, Ine A., Kuiper, Michael A., de Leeuw, Frank-Erik, de Man, Tjarda, van der Mast, Roos C., Osse, Robert-Jan, de Rooij, Sophia E., Spronk, Peter E., van der Voort, Peter H., van Gool, Willem A., and Slooter, Arjen J.

Published
2011
Full Text
View/download PDF

226. Multi-shell Diffusion MRI Models for White Matter Characterization in Cerebral Small Vessel Disease

Author

Konieczny, Marek J., primary, Dewenter, Anna, additional, ter Telgte, Annemieke, additional, Gesierich, Benno, additional, Wiegertjes, Kim, additional, Finsterwalder, Sofia, additional, Kopczak, Anna, additional, Hübner, Mathias, additional, Malik, Rainer, additional, Tuladhar, Anil M., additional, Marques, José P., additional, Norris, David G., additional, Koch, Alexandra, additional, Dietrich, Olaf, additional, Ewers, Michael, additional, Schmidt, Reinhold, additional, de Leeuw, Frank-Erik, additional, and Duering, Marco, additional

Published
2020
Full Text
View/download PDF

230. Network neuroscience of apathy in cerebrovascular disease

Author

Tay, Jonathan, primary, Lisiecka-Ford, Danuta M., additional, Hollocks, Matthew J., additional, Tuladhar, Anil M., additional, Barrick, Thomas R., additional, Forster, Anne, additional, O’Sullivan, Michael J., additional, Husain, Masud, additional, de Leeuw, Frank-Erik, additional, Morris, Robin G., additional, and Markus, Hugh S., additional

Published
2020
Full Text
View/download PDF

231. Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy

Author

ter Telgte, Annemieke, primary, Scherlek, Ashley A., additional, Reijmer, Yael D., additional, van der Kouwe, Andre J., additional, van Harten, Thijs, additional, Duering, Marco, additional, Bacskai, Brian J., additional, de Leeuw, Frank-Erik, additional, Frosch, Matthew P., additional, Greenberg, Steven M., additional, and van Veluw, Susanne J., additional

Published
2020
Full Text
View/download PDF

232. Alterations and test–retest reliability of functional connectivity network measures in cerebral small vessel disease

Author

Gesierich, Benno, primary, Tuladhar, Anil Man, additional, Telgte, Annemieke, additional, Wiegertjes, Kim, additional, Konieczny, Marek J., additional, Finsterwalder, Sofia, additional, Hübner, Mathias, additional, Pirpamer, Lukas, additional, Koini, Marisa, additional, Abdulkadir, Ahmed, additional, Franzmeier, Nicolai, additional, Norris, David G., additional, Marques, José P., additional, zu Eulenburg, Peter, additional, Ewers, Michael, additional, Schmidt, Reinhold, additional, Leeuw, Frank‐Erik, additional, and Duering, Marco, additional

Published
2020
Full Text
View/download PDF

235. Abstract 152: Genome-wide Association Study of Early-Onset Ischemic Stroke Identifies Novel Locus on Chromosome 12 Near BCL7A/MLXIP

Author

Jaworek, Thomas, primary, Kittner, Steven J, additional, Jern, Christina, additional, de Leeuw, Frank Erik, additional, Dichgans, Martin, additional, Malik, Rainer, additional, Fernandez, Israel, additional, Slowik, Agnieszka, additional, Boncoraglio, Giorgio Boncoraglio, additional, Lindgren, Arne, additional, Jimenez-Conde, Jordi, additional, Schmidt, Reinhold, additional, Sharma, Pankah, additional, Lemmens, Robin, additional, Melander, Olle, additional, Rothwell, Peter, additional, Levi, Christopher, additional, Sudlow, Catherine, additional, Debette, Stephanie, additional, Howson, Joanna, additional, Pare, Guillaume, additional, Markus, Hugh, additional, Salaheen, Danish, additional, Zand, Ramin, additional, Worrall, Brad, additional, Meschia, James, additional, Rundek, Tatjana, additional, Woo, Dan, additional, Lee, Jin-Moo, additional, Irvin, Ryan, additional, Rexrode, Kathyn, additional, Smoller, Sylvia, additional, Rosand, Jonathan, additional, Mueller, Martina, additional, and Salomaa, Veikko, additional

Published
2020
Full Text
View/download PDF

241. Value-based healthcare in ischemic stroke care: case-mix adjustment models for clinical and patient-reported outcomes

Author

Oemrawsingh, Arvind, primary, van Leeuwen, Nikki, additional, Venema, Esmee, additional, Limburg, Martien, additional, de Leeuw, Frank-Erik, additional, Wijffels, Markus P., additional, de Groot, Aafke J., additional, Hilkens, Pieter H. E., additional, Hazelzet, Jan A., additional, Dippel, Diederik W. J., additional, Bakker, Carla H., additional, Voogdt-Pruis, Helene R., additional, and Lingsma, Hester F., additional

Published
2019
Full Text
View/download PDF

247. Disruption of rich club organisation in cerebral small vessel disease

Author

Tuladhar, Anil M., Lawrence, Andrew, Norris, David G., Barrick, Thomas R., Markus, Hugh S., de Leeuw, Frank-Erik, and Magnetic Detection and Imaging

Subjects
Neuroinformatics, Diffusion tensor imaging, Diffusion Tensor Imaging, Rich club organization, Structural networks, Medizin, Cerebral small vessel disease, structural networks, graph-theory, Graph-theory, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], 150 000 MR Techniques in Brain Function, rich club organisation
Abstract

Contains fulltext : 170472.pdf (Publisher’s version ) (Open Access) Cerebral small vessel disease (SVD) is an important cause of vascular cognitive impairment. Recent studies have demonstrated that structural connectivity of brain networks in SVD is disrupted. However, little is known about the extent and location of the reduced connectivity in SVD. Here they investigate the rich club organisation-a set of highly connected and interconnected regions-and investigate whether there is preferential rich club disruption in SVD. Diffusion tensor imaging (DTI) and cognitive assessment were performed in a discovery sample of SVD patients (n = 115) and healthy control subjects (n = 50). Results were replicated in an independent dataset (49 SVD with confluent WMH cases and 108 SVD controls) with SVD patients having a similar SVD phenotype to that of the discovery cases. Rich club organisation was examined in structural networks derived from DTI followed by deterministic tractography. Structural networks in SVD patients were less dense with lower network strength and efficiency. Reduced connectivity was found in SVD, which was preferentially located in the connectivity between the rich club nodes rather than in the feeder and peripheral connections, a finding confirmed in both datasets. In discovery dataset, lower rich club connectivity was associated with lower scores on psychomotor speed (beta = 0.29, P < 0.001) and executive functions (beta = 0.20, P = 0.009). These results suggest that SVD is characterized by abnormal connectivity between rich club hubs in SVD and provide evidence that abnormal rich club organisation might contribute to the development of cognitive impairment in SVD. Hum Brain Mapp 38:1751-1766, 2017. (c) 2017 Wiley Periodicals, Inc.

Published
2017

250. Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration.

Author

Egle, Marco, Hilal, Saima, Tuladhar, A. M., Pirpamer, Lukas, Hofer, Edith, Duering, Marco, Wason, James, Morris, Robin G., Dichgans, Martin, Schmidt, Reinhold, Tozer, Daniel, Chen, Christopher, de Leeuw, Frank-Erik, and Markus, Hugh S.

Subjects
BRAIN, CEREBRAL small vessel diseases, RESEARCH, RESEARCH methodology, MAGNETIC resonance imaging, COGNITION, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, DEMENTIA, LONGITUDINAL method
Abstract

Objectives: It has been suggested that diffusion tensor imaging (DTI) measures sensitive to white matter (WM) damage may predict future dementia risk not only in cerebral small vessel disease (SVD), but also in mild cognitive impairment. To determine whether DTI measures were associated with cognition cross-sectionally and predicted future dementia risk across the full range of SVD severity, we established the International OPtimising mulTImodal MRI markers for use as surrogate markers in trials of Vascular Cognitive Impairment due to cerebrAl small vesseL disease collaboration which included six cohorts.Methods: Among the six cohorts, prospective data with dementia incidences were available for three cohorts. The associations between six different DTI measures and cognition or dementia conversion were tested. The additional contribution to prediction of other MRI markers of SVD was also determined.Results: The DTI measure mean diffusivity (MD) median correlated with cognition in all cohorts, demonstrating the contribution of WM damage to cognition. Adding MD median significantly improved the model fit compared to the clinical risk model alone and further increased in all single-centre SVD cohorts when adding conventional MRI measures. Baseline MD median predicted dementia conversion. In a study with severe SVD (SCANS) change in MD median also predicted dementia conversion. The area under the curve was best when employing a multimodal MRI model using both DTI measures and other MRI measures.Conclusions: Our results support a central role for WM alterations in dementia pathogenesis in all cohorts. DTI measures such as MD median may be a useful clinical risk predictor. The contribution of other MRI markers varied according to disease severity. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results