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2,633 results on '"Law, Matthew"'

201. Early versus deferred antiretroviral therapy for children older than 1 year infected with HIV (PREDICT): a multicentre, randomised, open-label trial

Author

Puthanakit, Thanyawee, Saphonn, Vonthanak, Ananworanich, Jintanat, Kosalaraksa, Pope, Hansudewechakul, Rawiwan, Vibol, Ung, Kerr, Stephen J, Kanjanavanit, Suparat, Ngampiyaskul, Chaiwat, Wongsawat, Jurai, Luesomboon, Wicharn, Ngo-Giang-Huong, Nicole, Chettra, Kea, Cheunyam, Theshinee, Suwarnlerk, Tulathip, Ubolyam, Sasiwimol, Shearer, William T, Paul, Robert, Mofenson, Lynne M, Fox, Lawrence, Law, Matthew G, Cooper, David A, Phanuphak, Praphan, Vun, Mean Chhi, and Ruxrungtham, Kiat

Published
2012
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203. Validation of self-reported sun exposure against electronic ultraviolet radiation dosimeters.

Author

Zhang, Ran, Smit, Amelia K, Espinoza, David, Allen, Martin, Reyes-Marcelino, Gillian, Kimlin, Michael G, Lo, Serigne N, Sharman, Ashleigh R, Law, Matthew H, Kanetsky, Peter A, Mann, Graham J, and Cust, Anne E

Subjects
SUNSHINE, DOSIMETERS, BLAND-Altman plot, ULTRAVIOLET radiation, ULTRAVIOLET radiation measurement, SOLAR ultraviolet radiation
Abstract

From the dosimeter data we derived: (i) time spent outdoors exposed to UV, defined as any 8-s measurements with UV values of >0; and (ii) total standard erythemal doses (SEDs) as a measure of UV dose. Table 1 Spearman rank correlations between weekend and weekday ultraviolet radiation (UV) exposure measured as standard erythemal doses (SEDs) using electronic UV dosimeters HT

. Validation, exposure measurement, ultraviolet radiation, dosimetry, questionnaire, skin cancer Keywords: Validation; exposure measurement; ultraviolet radiation; dosimetry; questionnaire; skin cancer EN Validation exposure measurement ultraviolet radiation dosimetry questionnaire skin cancer 324 328 5 02/16/23 20230201 NES 230201 Ultraviolet radiation (UV) exposure is the main risk factor for skin cancer[1] and skin cancer prevention research and health promotion programme evaluation relies on the accurate measurement of sun exposure using questionnaires. [Extracted from the article]

Published
2023
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204. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

Author

Law, Matthew H, Bishop, D Timothy, Lee, Jeffrey E, Brossard, Myriam, Martin, Nicholas G, Moses, Eric K, Song, Fengju, Barrett, Jennifer H, Kumar, Rajiv, Easton, Douglas F, Pharoah, Paul D P, Swerdlow, Anthony J, Kypreou, Katerina P, Taylor, John C, Harland, Mark, Randerson-Moor, Juliette, Akslen, Lars A, Andresen, Per A, Avril, Marie-Françoise, Azizi, Esther, Scarrà, Giovanna Bianchi, Brown, Kevin M, Dȩbniak, Tadeusz, Duffy, David L, Elder, David E, Fang, Shenying, Friedman, Eitan, Galan, Pilar, Ghiorzo, Paola, Gillanders, Elizabeth M, Goldstein, Alisa M, Gruis, Nelleke A, Hansson, Johan, Helsing, Per, Hočevar, Marko, Höiom, Veronica, Ingvar, Christian, Kanetsky, Peter A, Chen, Wei V, Landi, Maria Teresa, Lang, Julie, Lathrop, G Mark, Lubiński, Jan, Mackie, Rona M, Mann, Graham J, Molven, Anders, Montgomery, Grant W, Novaković, Srdjan, Olsson, Håkan, Puig, Susana, Puig-Butille, Joan Anton, Qureshi, Abrar A, Radford-Smith, Graham L, van der Stoep, Nienke, van Doorn, Remco, Whiteman, David C, Craig, Jamie E, Schadendorf, Dirk, Simms, Lisa A, Burdon, Kathryn P, Nyholt, Dale R, Pooley, Karen A, Orr, Nick, Stratigos, Alexander J, Cust, Anne E, Ward, Sarah V, Hayward, Nicholas K, Han, Jiali, Schulze, Hans-Joachim, Dunning, Alison M, Bishop, Julia A Newton, Demenais, Florence, Amos, Christopher I, MacGregor, Stuart, and Iles, Mark M

Published
2015
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205. Independent evaluation of melanoma polygenic risk scores in UK and Australian prospective cohorts*

Author

Steinberg, Julia, primary, Iles, Mark M., additional, Lee, Jin Yee, additional, Wang, Xiaochuan, additional, Law, Matthew H., additional, Smit, Amelia K., additional, Nguyen‐Dumont, Tu, additional, Giles, Graham G., additional, Southey, Melissa C., additional, Milne, Roger L., additional, Mann, Graham J., additional, Bishop, D. Timothy, additional, MacInnis, Robert J., additional, and Cust, Anne E., additional

Published
2022
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206. Higher polygenic risk for melanoma is associated with improved survival

Author

Seviiri, Mathias, primary, Scolyer, Richard, additional, Bishop, Timothy D., additional, Iles, Mark M., additional, Lo, Serigne N., additional, Stretch, Johnathan R., additional, Saw, Robyn P.M., additional, Nieweg, Omgo E., additional, Shannon, Kerwin F., additional, Spillane, Andrew J., additional, Gordon, Scott D., additional, Olsen, Catherine M, additional, Whiteman, David C., additional, Landi, Maria T., additional, Thompson, John F., additional, Long, Georgina, additional, MacGregor, Stuart, additional, and Law, Matthew H., additional

Published
2022
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214. Additional file 1 of Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

Author

Seviiri, Mathias, Scolyer, Richard A., Bishop, D. Timothy, Newton-Bishop, Julia A., Iles, Mark M., Lo, Serigne N., Stretch, Johnathan R., Saw, Robyn P. M., Nieweg, Omgo E., Shannon, Kerwin F., Spillane, Andrew J., Gordon, Scott D., Olsen, Catherine M., Whiteman, David C., Landi, Maria Teresa, Thompson, John F., Long, Georgina V., MacGregor, Stuart, and Law, Matthew H.

Abstract

Additional file 1: Figure 1. Manhattan plot for the MSS GWAS meta-analysis between MIA and UKB cohorts. Figure 2. Skin colour polygenic risk score model performance in the validation cohort (QSkin). The x-axis represents the different melanoma polygenic risk score (PRS) models of varying fractions of causal SNPs (i.e. 1 (F0), 0.1 (F1), 0.01 (F2),0.001(F3),0.0001 (F4) and 0.00002 (F5)) at the different radii of the linkage disequilibrium (LD) (i.e. 2 megabase (mb) and 5 mb). The y-axis represents Nagelkerke’s R2 (%) for each of the 12 PRS models. The horizontal dashed black line highlights the optimal model (F1-2mb) (i.e. with the highest Nagelkerke’s R2). Figure 3. The association between polygenic risk scores and the risk of melanoma in QSkin. Figure 4. The association by quartile of polygenic risk for melanoma susceptibility and melanoma specific survival in the MIA cohort. Figure 5. Association of standalone skin colour and naevus PRSs and melanoma specific survival in MIA and UKB.

Published
2022
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216. Risk of Myocardial Infarction in Patients with HIV Infection Exposed to Specific Individual Antiretroviral Drugs from the 3 Major Drug Classes: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study

Author

Worm, Signe Westring, Sabin, Caroline, Weber, Rainer, Reiss, Peter, EI-Sadr, Wafaa, Dabis, Francois, De Wit, Stephane, Law, Matthew, Monforte, Antonella D'Arminio, Friis-Møller, Nina, Kirk, Ole, Fontas, Eric, Weller, Ian, Phillips, Andrew, and Lundgren, Jens

Published
2010

217. A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Author

Ong, Jue-Sheng, Dixon-Suen, Suzanne C., Han, Xikun, An, Jiyuan, Liyanage, Upekha, Dusingize, Jean-Cluade, Schumacher, Johannes, Gockel, Ines, Böhmer, Anne, Jankowski, Janusz, Palles, Claire, O’Mara, Tracy, Spurdle, Amanda, Law, Matthew H., Iles, Mark M., Pharoah, Paul, Berchuck, Andrew, Zheng, Wei, Thrift, Aaron P., Olsen, Catherine, Neale, Rachel E., Gharahkhani, Puya, Webb, Penelope M., MacGregor, Stuart, Fitzgerald, Rebecca, Buas, Matt, Gammon, Marilie D., Corley, Douglas A., Shaheen, Nicholas J., Hardie, Laura J., Bird, Nigel C., Reid, Brian J., Chow, Wong-Ho, Risch, Harvey A., Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H., Whiteman, David E., Vaughan, Thomas, Agee, M., Alipanahi, B., Auton, A., Bell, R. K., Bryc, K., Elson, S. L., Fontanillas, P., Furlotte, N. A., Hinds, D. A., Huber, K. E., Kleinman, A., Litterman, N. K., McIntyre, M. H., Mountain, J. L., Noblin, E. S., Northover, C. A. M., Pitts, S. J., Sathirapongsasuti, J. Fah, Sazonova, O. V., Shelton, J. F., Shringarpure, S., Tian, C., Tung, J. Y., Vacic, V., Wilson, C. H., Ong, Jue-Sheng [0000-0002-6062-710X], Dixon-Suen, Suzanne C. [0000-0003-3714-8386], Han, Xikun [0000-0002-3823-7308], Gockel, Ines [0000-0001-7423-713X], Böhmer, Anne [0000-0002-5716-786X], O’Mara, Tracy [0000-0002-5436-3232], Spurdle, Amanda [0000-0003-1337-7897], Law, Matthew H. [0000-0002-4303-8821], Iles, Mark M. [0000-0002-2603-6509], Pharoah, Paul [0000-0001-8494-732X], Zheng, Wei [0000-0003-1226-070X], Thrift, Aaron P. [0000-0002-0084-5308], Olsen, Catherine [0000-0003-4483-1888], Gharahkhani, Puya [0000-0002-4203-5952], Webb, Penelope M. [0000-0003-0733-5930], MacGregor, Stuart [0000-0001-6731-8142], and Apollo - University of Cambridge Repository

Subjects
631/67/68, 45/43, article, 692/699/67/2195, 692/4028/67/2324
Abstract

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.

Published
2021
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223. Modelling response strategies for controlling gonorrhoea outbreaks in men who have sex with men in Australia

Author

Duan, Qibin, primary, Carmody, Chris, additional, Donovan, Basil, additional, Guy, Rebecca J., additional, Hui, Ben B., additional, Kaldor, John M., additional, Lahra, Monica M., additional, Law, Matthew G., additional, Lewis, David A., additional, Maley, Michael, additional, McGregor, Skye, additional, McNulty, Anna, additional, Selvey, Christine, additional, Templeton, David J., additional, Whiley, David M., additional, Regan, David G., additional, and Wood, James G., additional

Published
2021
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228. Effects of unplanned treatment interruptions on HIV treatment failure – results from TAHOD

Author

Jiamsakul, Awachana, Kerr, Stephen J., Ng, Oon Tek, Lee, Man Po, Chaiwarith, Romanee, Yunihastuti, Evy, Van Nguyen, Kinh, Pham, Thuy Thanh, Kiertiburanakul, Sasisopin, Ditangco, Rossana, Saphonn, Vonthanak, Sim, Benedict L. H., Merati, Tuti Parwati, Wong, Wingwai, Kantipong, Pacharee, Zhang, Fujie, Choi, Jun Yong, Pujari, Sanjay, Kamarulzaman, Adeeba, Oka, Shinichi, Mustafa, Mahiran, Ratanasuwan, Winai, Petersen, Boondarika, Law, Matthew, Kumarasamy, Nagalingeswaran, Mean, CV, Khol, V, Zhao, HX, Han, N, Li, PCK, Lam, W, Chan, YT, Saghayam, S, Ezhilarasi, C, Joshi, K, Gaikwad, S, Chitalikar, A, Wirawan, DN, Yuliana, F, Imran, D, Widhani, A, Tanuma, J, Nishijima, T, Na, S, Kim, JM, Gani, YM, David, R, Omar, SF Syed, Ponnampalavanar, S, Azwa, I, Nordin, N, Uy, E, Bantique, R, Ku, WW, Wu, PC, Lim, PL, Lee, LS, Ohnmar, PS, Ruxrungtham, K, Avihingsanon, A, Chusut, P, Sungkanuparph, S, Chumla, L, Sanmeema, N, Sirisanthana, T, Kotarathititum, W, Praparattanapan, J, Kambua, P, Sriondee, R, Bui, VH, Nguyen, THD, Cuong, DD, Ha, HL, Sohn, AH, Durier, N, Petersen, B, Jiamsakul, A, and Boettiger, DC

Published
2016
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233. Clinical outcomes of two-drug regimens vs. three-drug regimens in antiretroviral treatment-experienced people living with HIV

Author

Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gilles, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F, Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d’Arminio Monforte, Antonella, Miró, Jose M, Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Anders, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan-Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M, Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C, Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D, Peters, Lars, Bansi-Matharu, Loveleen, Mocroft, Amanda, Greenberg, Lauren, Ryom, Lene, Neesgaard, Bastian, Wandeler, Gille, Staub, Therese, Gisinger, Martin, Skoll, Michael, Günthard, Huldrych F, Scherrer, Alexandra, Mussini, Cristina, Smith, Colette, Johnson, Margaret, De Wit, Stéphane, Necsoi, Coca, Pradier, Christian, Wit, Ferdinand, Lehmann, Clara, d'Arminio Monforte, Antonella, Miró, Jose M, Castagna, Antonella, Spagnuolo, Vincenzo, Sönnerborg, Ander, Law, Matthew, Hutchinson, Jolie, Chkhartishvili, Nikoloz, Bolokadze, Natalia, Wasmuth, Jan-Christian, Stephan, Christoph, Vannappagari, Vani, Rogatto, Felipe, Llibre, Josep M, Duvivier, Claudine, Hoy, Jennifer, Bloch, Mark, Bucher, Heiner C, Calmy, Alexandra, Volny Anne, Alain, Pelchen-Matthews, Annegret, Lundgren, Jens D, Peters, Lar, Bansi-Matharu, Loveleen, and Mocroft, Amanda

Subjects
antiretroviral treatment, two-drug regimens, HIV, 610 Medicine & health, dual therapy, clinical outcomes
Abstract

Background: Limited data exist comparing clinical outcomes of two-drug regimens (2DRs) and three-drug regimens (3DRs) in people living with HIV. Methods: Antiretroviral treatment-experienced individuals in RESPOND switching to a new 2DR or 3DR from 1/1/12-1/10/18 were included. The incidence of clinical events (AIDS, non-AIDS cancer, cardiovascular disease, end-stage liver and renal disease, death) was compared between regimens using Poisson regression. Results: Of 9791 individuals included, 1088 (11.1%) started 2DRs and 8703 (88.9%) 3DRs. The most common 2DRs were dolutegravir plus lamivudine (22.8%) and raltegravir plus boosted darunavir (19.8%); the most common 3DR was dolutegravir plus 2 nucleoside reverse transcriptase inhibitors (46.9%). Individuals on 2DRs were older (median 52.6 years [interquartile range 46.7-59.0] vs 47.7 [39.7-54.3]), and a higher proportion had ≥1 comorbidity (81.6% vs 73.9%).There were 619 events during 27,159 person-years of follow-up (PYFU): 540 (incidence rate [IR] 22.5/1000 PYFU [95% CI 20.7-24.5]) on 3DRs, 79 (30.9/1000 PYFU [24.8-38.5]) on 2DRs. The most common events were death (7.5/1000 PYFU [95% CI 6.5-8.6]) and non-AIDS cancer (5.8/1000 PYFU [4.9-6.8]). After adjustment for baseline demographic and clinical characteristics, there was a similar incidence of events on both regimen types (2DRs vs 3DRs IR ratio: 0.92 [0.72-1.19]; p=0.53). Conclusions: This is the first large, international cohort assessing clinical outcomes on 2DRs. After accounting for baseline characteristics, there was a similar incidence of events on 2DRs and 3DRs. 2DRs appear to be a viable treatment option with regard to clinical outcomes; further research on resistance barriers and long-term durability of 2DRs is needed.

Published
2020

234. The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

Author

Iles, Mark M., Bishop, D. Timothy, Taylor, John C., Hayward, Nicholas K., Brossard, Myriam, Cust, Anne E., Dunning, Alison M., Lee, Jeffrey E., Moses, Eric K., Akslen, Lars A., Andresen, Per A., Avril, Marie-Françoise, Azizi, Esther, Scarrà, Giovanna Bianchi, Brown, Kevin M., Dębniak, Tadeusz, Elder, David E., Friedman, Eitan, Ghiorzo, Paola, Gillanders, Elizabeth M., Goldstein, Alisa M., Gruis, Nelleke A., Hansson, Johan, Harland, Mark, Helsing, Per, Hočevar, Marko, Höiom, Veronica, Ingvar, Christian, Kanetsky, Peter A., Landi, Maria Teresa, Lang, Julie, Lathrop, G. Mark, Lubiński, Jan, Mackie, Rona M., Martin, Nicholas G., Molven, Anders, Montgomery, Grant W., Novaković, Srdjan, Olsson, Håkan, Puig, Susana, Puig-Butille, Joan Anton, Radford-Smith, Graham L., Randerson-Moor, Juliette, van der Stoep, Nienke, van Doorn, Remco, Whiteman, David C., MacGregor, Stuart, Pooley, Karen A., Ward, Sarah V., Mann, Graham J., Amos, Christopher I., Pharoah, Paul D. P., Demenais, Florence, Law, Matthew H., Newton Bishop, Julia A., and Barrett, Jennifer H.

Published
2014
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235. Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation ofOBFC1

Author

Cardinale, Antonella, primary, Cantalupo, Sueva, additional, Lasorsa, Vito Alessandro, additional, Montella, Annalaura, additional, Cimmino, Flora, additional, Succoio, Mariangela, additional, Vermeulen, Michiel, additional, Baltissen, Marijke P, additional, Esposito, Matteo, additional, Avitabile, Marianna, additional, Formicola, Daniela, additional, Testori, Alessandro, additional, Bonfiglio, Ferdinando, additional, Ghiorzo, Paola, additional, Scalvenzi, Massimiliano, additional, Ayala, Fabrizio, additional, Zambrano, Nicola, additional, Iles, Mark M, additional, Xu, Mai, additional, Law, Matthew H, additional, Brown, Kevin M, additional, Iolascon, Achille, additional, and Capasso, Mario, additional

Published
2021
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240. Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms

Author

Zhang, Tongwu, primary, Choi, Jiyeon, additional, Dilshat, Ramile, additional, Einarsdóttir, Berglind Ósk, additional, Kovacs, Michael A., additional, Xu, Mai, additional, Malasky, Michael, additional, Chowdhury, Salma, additional, Jones, Kristine, additional, Bishop, D. Timothy, additional, Goldstein, Alisa M., additional, Iles, Mark M., additional, Landi, Maria Teresa, additional, Law, Matthew H., additional, Shi, Jianxin, additional, Steingrímsson, Eiríkur, additional, and Brown, Kevin M., additional

Published
2021
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241. A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR

Author

Xu, Mai, primary, Mehl, Lindsey, additional, Zhang, Tongwu, additional, Thakur, Rohit, additional, Sowards, Hayley, additional, Myers, Timothy, additional, Jessop, Lea, additional, Chesi, Alessandra, additional, Johnson, Matthew E., additional, Wells, Andrew D., additional, Michael, Helen T., additional, Bunda, Patricia, additional, Jones, Kristine, additional, Higson, Herbert, additional, Hennessey, Rebecca C., additional, Jermusyk, Ashley, additional, Kovacs, Michael A., additional, Landi, Maria Teresa, additional, Iles, Mark M., additional, Goldstein, Alisa M., additional, Choi, Jiyeon, additional, Chanock, Stephen J., additional, Grant, Struan F.A., additional, Chari, Raj, additional, Merlino, Glenn, additional, Law, Matthew H., additional, and Brown, Kevin M., additional

Published
2021
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243. The longer-term effects of access to HIV self-tests on HIV testing frequency in high-risk gay and bisexual men: follow-up data from a randomised controlled trial

Author

Zhang, Ye, primary, Jamil, Muhammad S, additional, Smith, Kirsty S, additional, Applegate, Tanya L, additional, Prestage, Garrett, additional, Holt, Martin, additional, Keen, Phillip, additional, Bavinton, Benjamin R, additional, Chen, Marcus, additional, Conway, Damian P, additional, Wand, Handan, additional, McNulty, Anna M, additional, Russell, Darren, additional, Vaughan, Matthew, additional, Batrouney, Colin, additional, Wiseman, Virginia, additional, Fairley, Christopher K, additional, Grulich, Andrew E, additional, Law, Matthew, additional, Kaldor, John M, additional, and Guy, Rebecca J, additional

Published
2021
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247. Prevalence and determinants of inappropriate antibiotic dispensing at private drug retail outlets in urban and rural areas of Indonesia: a mixed methods study

Author

Wulandari, Luh Putu Lila, primary, Khan, Mishal, additional, Liverani, Marco, additional, Ferdiana, Astri, additional, Mashuri, Yusuf Ari, additional, Probandari, Ari, additional, Wibawa, Tri, additional, Batura, Neha, additional, Schierhout, Gill, additional, Kaldor, John, additional, Guy, Rebecca, additional, Law, Matthew, additional, Day, Richard, additional, Hanefeld, Johanna, additional, Parathon, Harry, additional, Jan, Stephen, additional, Yeung, Shunmay, additional, and Wiseman, Virginia, additional

Published
2021
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249. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Author

Rahmioglu, Nilufer, Mortlock, Sally, Ghiasi, Marzieh, Møller, Peter L., Stefansdottir, Lilja, Galarneau, Geneviève, Turman, Constance, Danning, Rebecca, Law, Matthew H., Sapkota, Yadav, Christofidou, Paraskevi, Skarp, Sini, Giri, Ayush, Banasik, Karina, Krassowski, Michal, Lepamets, Maarja, Marciniak, Błażej, Nõukas, Margit, Perro, Danielle, Sliz, Eeva, Sobalska-Kwapis, Marta, Thorleifsson, Gudmar, Topbas-Selcuki, Nura F., Vitonis, Allison, Westergaard, David, Arnadottir, Ragnheidur, Burgdorf, Kristoffer S., Campbell, Archie, Cheuk, Cecilia S. K., Clementi, Caterina, Cook, James, De Vivo, Immaculata, DiVasta, Amy, Dorien, O., Donoghue, Jacqueline F., Edwards, Todd, Fontanillas, Pierre, Fung, Jenny N., Geirsson, Reynir T., Girling, Jane E., Harkki, Paivi, Harris, Holly R., Healey, Martin, Heikinheimo, Oskari, Holdsworth-Carson, Sarah, Hostettler, Isabel C., Houlden, Henry, Houshdaran, Sahar, Irwin, Juan C., Jarvelin, Marjo-Riitta, Kamatani, Yoichiro, Kennedy, Stephen H., Kepka, Ewa, Kettunen, Johannes, Kubo, Michiaki, Kulig, Bartosz, Kurra, Venla, Laivuori, Hannele, Laufer, Marc R., Lindgren, Cecilia M., MacGregor, Stuart, Mangino, Massimo, Martin, Nicholas G., Matalliotaki, Charoula, Matalliotakis, Michail, Murray, Alison D., Ndungu, Anne, Nezhat, Camran, Olsen, Catherine M., Opoku-Anane, Jessica, Padmanabhan, Sandosh, Paranjpe, Manish, Peters, Maire, Polak, Grzegorz, Porteous, David J., Rabban, Joseph, Rexrode, Kathyrn M., Romanowicz, Hanna, Saare, Merli, Saavalainen, Liisu, Schork, Andrew J., Sen, Sushmita, Shafrir, Amy L., Siewierska-Górska, Anna, Słomka, Marcin, Smith, Blair H., Smolarz, Beata, Szaflik, Tomasz, Szyłło, Krzysztof, Takahashi, Atsushi, Terry, Kathryn L., Tomassetti, Carla, Treloar, Susan A., Vanhie, Arne, Vincent, Katy, Vo, Kim C., Werring, David J., Zeggini, Eleftheria, Zervou, Maria I., Adachi, Sosuke, Buring, Julie E., Ridker, Paul M., D’Hooghe, Thomas, Goulielmos, George N., Hapangama, Dharani K., Hayward, Caroline, Horne, Andrew W., Low, Siew-Kee, Martikainen, Hannu, Chasman, Daniel I., Rogers, Peter A. W., Saunders, Philippa T., Sirota, Marina, Spector, Tim, Strapagiel, Dominik, Tung, Joyce Y., Whiteman, David C., Giudice, Linda C., Velez-Edwards, Digna R., Uimari, Outi, Kraft, Peter, Salumets, Andres, Nyholt, Dale R., Mägi, Reedik, Stefansson, Kari, Becker, Christian M., Yurttas-Beim, Piraye, Steinthorsdottir, Valgerdur, Nyegaard, Mette, Missmer, Stacey A., Montgomery, Grant W., Morris, Andrew P., and Zondervan, Krina T.

Abstract

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genome-wide significant loci comprising 49 distinct association signals. Effect sizes were largest for stage 3/4 disease, driven by ovarian endometriosis. Identified signals explained up to 5.01% of disease variance and regulated expression or methylation of genes in endometrium and blood, many of which were associated with pain perception/maintenance (SRP14/BMF, GDAP1, MLLT10, BSNand NGF). We observed significant genetic correlations between endometriosis and 11 pain conditions, including migraine, back and multisite chronic pain (MCP), as well as inflammatory conditions, including asthma and osteoarthritis. Multitrait genetic analyses identified substantial sharing of variants associated with endometriosis and MCP/migraine. Targeted investigations of genetically regulated mechanisms shared between endometriosis and other pain conditions are needed to aid the development of new treatments and facilitate early symptomatic intervention.

Published
2023
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250. The treatment outcomes of antiretroviral substitutions in routine clinical settings in Asia; data from the TREAT Asia HIV Observational Database (TAHOD)

Author

Jung, In Young, Boettiger, David, Wong, Wing Wai, Lee, Man Po, Kiertiburanakul, Sasisopin, Chaiwarith, Romanee, Avihingsanon, Anchalee, Tanuma, Junko, Kumarasamy, Nagalingeswaran, Kamarulzaman, Adeeba, Zhang, Fujie, Kantipong, Pacharee, Ng, Oon Tek, Sim, Benedict Lim Heng, Law, Matthew, Ross, Jeremy, and Choi, Jun Yong

Subjects
Antiviral agents -- Dosage and administration -- Patient outcomes -- Statistics, Anti-HIV agents -- Dosage and administration -- Patient outcomes -- Statistics, HIV infection -- Drug therapy -- Patient outcomes -- Statistics, Health
Abstract

: Introduction: Although substitutions of antiretroviral regimen are generally safe, most data on substitutions are based on results from clinical trials. The objective of this study was to evaluate the treatment outcomes of substituting antiretroviral regimen in virologically suppressed HIV‐infected patients in non‐clinical trial settings in Asian countries. Methods: The study population consisted of HIV‐infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD). Individuals were included in this analysis if they started combination antiretroviral treatment (cART) after 2002, were being treated at a centre that documented a median rate of viral load monitoring ≥0.8 tests/patient/year among TAHOD enrolees, and experienced a minor or major treatment substitution while on virally suppressive cART. The primary endpoint to evaluate outcomes was clinical or virological failure (VF), followed by an ART class change. Clinical failure was defined as death or an AIDS diagnosis. VF was defined as confirmed viral load measurements ≥400 copies/mL followed by an ART class change within six months. Minor regimen substitutions were defined as within‐class changes and major regimen substitutions were defined as changes to a drug class. The patterns of substitutions and rate of clinical or VF after substitutions were analyzed. Results: Of 3994 adults who started ART after 2002, 3119 (78.1%) had at least one period of virological suppression. Among these, 1170 (37.5%) underwent a minor regimen substitution, and 296 (9.5%) underwent a major regimen substitution during suppression. The rates of clinical or VF were 1.48/100 person years (95% CI 1.14 to 1.91) in the minor substitution group, 2.85/100 person years (95% CI 1.88 to 4.33) in the major substitution group and 2.53/100 person years (95% CI 2.20 to 2.92) among patients that did not undergo a treatment substitution. Conclusions: The rate of clinical or VF was low in both major and minor substitution groups, showing that regimen substitution is generally effective in non‐clinical trial settings in Asian countries., Introduction Combination antiretroviral treatments (cART) have been widely available in Asia since 2003. However, most Asian HIV clinics have limited resources and are able to prescribe regimens based on WHO [...]

Published
2017
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