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3,459 results on '"Lange K"'

206. Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? Immunohistochemical and molecular findings on routinely processed bone marrow biopsy specimens

Author

Horny, H-P, Lange, K, Sotlar, K, and Valent, P

Subjects
Clinical pathology -- Research -- Physiological aspects -- Health aspects, Gene expression -- Physiological aspects -- Research -- Genetic aspects -- Health aspects, Bone marrow -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, Lymphocytes -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, B cells -- Genetic aspects -- Physiological aspects -- Research -- Health aspects, Mast cells -- Genetic aspects -- Physiological aspects -- Health aspects -- Research, Histology, Pathological -- Research -- Health aspects -- Physiological aspects, Mast cell disease -- Health aspects -- Diagnosis -- Research -- Genetic aspects, Health, Diagnosis, Physiological aspects, Research, Genetic aspects, Health aspects
Abstract

Aims: To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with [...]

Published
2003

213. Optimal design in dynamic PET data acquisition: a new approach using simulated annealing and component-wise metropolis updating

Author

Liao, W.-H., Lange, K., Bergsneider, M., and Huang, S.-C.

Subjects
PET imaging -- Analysis, PET imaging -- Usage, Glucose, Dextrose, Monte Carlo method -- Usage, Business, Electronics, Electronics and electrical industries
Abstract

Dynamic positron emission tomography (PET) is a powerful tool of measuring biological activities in vivo. Due to the inherent high noise level, there are always concerns about how to increase the signal-to-noise ratio. One possible approach is to optimize the experimental design. In this paper, we propose a discretized representation of the experimental design and transform it to a combinatorial problem. This combinatorial optimization problem then can be solved using simulated annealing with component-wise Metropolis Monte Carlo simulation. We showed that using this novel approach one can design an optimal input function as well as an optimal sampling schedule efficiently. Our results show that the current dynamic scanning of approximately 20 frames does not give us much more information than an optimized four-frame schedule, and needlessly increases storage requirements. This is consistent with the conclusion given by Li et al. [1]. We also reproduced the optimal sampling schedule for fluorodeoxy-glucose (FDG) study proposed in [1]. Moreover, we show that the single bolus injection is almost optimal in the sense of D-optimal design, as well as many other measures. Index Terms--Input function, optimal sampling schedule, tissue activity curve.

Published
2002

236. Flow cytometric assays for CAR T cell manufacturing and patient immunomonitoring, comprising specific CAR detection reagents, stabilized pre-mixed cocktails, and automated data acquisition and analysis

Author

Mues, M., primary, Winkels, M., additional, Lange, K., additional, Stiem, L., additional, Janz, E., additional, Biedermann, S., additional, Niemöller, M., additional, Missing, D., additional, Jürgens, N., additional, Holzer, T., additional, Dose, C., additional, Siewert, C., additional, and Richter, A., additional

Published
2020
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241. The SWEET Project - a model for Europe and beyond?: INV20

Author

Danne, T., Šumník, Z., Veeze, H., de Beaufort, C., Robert, J.-J., Forsander, G., Pańkowska, E., Allgrove, J., Waldron, S., Serban, V., Gerasimidou-Vazeou, A., Lange, K., Kordonouri, O., Pinelli, L., Raposo, J.-F., Madacsy, L., Felton, A.-M., Rurik, I., and Aschemeier, B.

Published
2009

250. Psycho-soziale Belastungen und Versorgungsbedarf von Familien mit einem chronisch kranken Kind am Beispiel von Typ 1 Diabetes

Author

Dehn-Hindenberg, A and Lange, K

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die chronische Erkrankung eines Kindes stellt die betroffenen Familien vor komplexe Aufgaben, die mit den beruflichen und familiären Anforderungen abgestimmt werden müssen. Der Fokus der Langzeittherapie richtet sich nicht allein auf das betroffene Kind, sondern bezieht das gesamte[zum vollständigen Text gelangen Sie über die oben angegebene URL], 18. Deutscher Kongress für Versorgungsforschung (DKVF)

Published
2019
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