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203. In memoriam:Leif Mosekilde

Author

Rejnmark, Lars, Brixen, Kim, Kassem, Moustapha, Hermann, Pernille, Vestergaard, Peter, Eriksen, Erik Fink, Bollerslev, Jens, Nielsen, Henning K, Charles, Peder, and Langdahl, Bente

Published
2018
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209. OP0133 ONE-YEAR PROGRESSION OF EROSIVE DISEASE EVALUATED WITH HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY IN PATIENTS WITH ANTI-CITRULLINATED PEPTIDE ANTIBODIES AND ARTHRALGIA

Author

Keller, Kresten Krarup, primary, Thomsen, Jesper Skovhus, additional, Stengaard-Pedersen, Kristian, additional, Therkildsen, Josephine, additional, Nielsen, Andreas Wiggers, additional, Schiøttz-Christensen, Berit, additional, Svendsen, Lone, additional, Graakjær, Merete, additional, Petersen, Peter Mosborg, additional, Unger, Barbara, additional, Kjær, Gøren Geil, additional, Langdahl, Bente, additional, and Hauge, Ellen Margrethe, additional

Published
2019
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211. Evaluation of cardiovascular biomarkers In HIV-infected patients switching to abacavir or tenofovir based therapy

Author

Langdahl Bente L, Nielsen Ulla S, Frederiksen Christian A, Melchjorsen Jesper, Tolstrup Martin, Rasmussen Thomas A, Østergaard Lars, and Laursen Alex L

Subjects
HIV, abacavir, tenofovir, cardiovascular disease, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Our objective was to evaluate and compare the effect of abacavir on levels of biomarkers associated with cardiovascular risk. Methods In an open-label randomized trial, HIV-infected patients were randomized 1:1 to switch from zidovudine/lamivudine to abacavir/lamivudine or tenofovir/emtricitabine. In the present analysis, we measured levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), E-selectin, and myeloperoxidase (MPO) at baseline and 4, 12, and 48 weeks after randomization. D-dimer and fasting lipids were measured at baseline and weeks 12 and 48. Levels of biomarkers at all time points and changes from baseline were compared across study arms using Wilcoxon rank sum test. Results Of 40 included patients, 35 completed 48 weeks of randomized therapy and follow up. Levels of E-selectin (P = 0.004) and sVCAM-1 (P = 0.041) increased transiently from baseline to week 4 in the abacavir arm compared with the tenofovir arm, but no long-term increases were detected. We found no significant differences between study arms in the levels or changes in the levels of sICAM-1, MPO, d-dimer, IL-6, or hs-CRP. Levels of total cholesterol and high density lipoprotein (HDL) increased in the abacavir arm relative to the tenofovir arm, but no difference was found in total cholesterol/HDL ratio. Conclusion In patients randomized to abacavir-based HIV-treatment transient increases were seen in the plasma levels of E-selectin and sVCAM-1 compared with treatment with tenofovir, but no difference between study arms was found in other biomarkers associated with endothelial dysfunction, inflammation, or coagulation. The clinical significance of these findings is uncertain. Trial Regestration Clinicaltrials.gov identifier: NCT00647244.

Published
2011
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212. Can bone loss be reversed by antithyroid drug therapy in premenopausal women with Graves' disease?

Author

Belsing Tina Z, Tofteng Charlotte, Langdahl Bente L, Charles Peder, and Feldt-Rasmussen Ulla

Subjects
Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Context Hyperthyroidism can lead to reduced bone mineral density (BMD) and increased fracture risk particularly in postmenopausal women, but the mechanism behind is still unclear. Objective Prospective examination of the influence of thyroid hormones and/or thyroid autoantibodies on BMD in premenopause. Design We have examined 32 premenopausal women with untreated active Graves' disease from time of diagnosis, during 18 months of antithyroid drug therapy (ATD) and additionally 18 months after discontinuing ATD. Variables of thyroid metabolism, calcium homeostasis and body composition were measured every 3 months. BMD of lumbar spine and femoral neck were measured at baseline, 18 ± 3 and 36 ± 3 months. Data were compared to base line, a sex- and age matched control group and a group of patients with Hashimoto's thyroiditis treated with non-suppressive doses of levothyroxine. Results The study showed significantly (p < 0.002) lower BMD in the thyrotoxic state compared to the control group with subsequent significant improvement during 18 ± 3 months of ATD compared to baseline (p < 0.001). However, during the following 18 months after stopping ATD femoral neck BMD decreased again unrelated to age (more than 0.4% per year, p < 0,002). The wellestablished effect of thyrotoxicosis on calcium homeostasis was confirmed. The positive predictor for best BMD was TSH receptor antibodies (TRAb) while free T4 correlated negatively in the thyrotoxic female Graves' patients (p < 0.02 and p < 0.003). In healthy controls and patients with treated Graves' disease both TSH and T4 correlated negatively to the bone mass (BMC) (p < 0.003). Conclusion The results indicated a clinically relevant impact of thyroid function on bone modulation also in premenopausal women with Graves' disease, and further indicated the possibility for a direct action of TRAb on bones.

Published
2010
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214. Disentangling the genetics of lean mass

Author

Karasik, David, Zillikens, M. Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Ines, Bennett, David A., Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B., Broer, Linda, Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A., Cawthon, Peggy M., Chambers, John C., Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R., de Groot, Lisette C. P. G. M., De Jager, Phillip L., Demuth, Ilja, Diatchenko, Luda, Econs, Michael J., Eiriksdottir, Gudny, Enneman, Anke W., Eriksson, Joel, Eriksson, Johan G., Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J., Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koller, Daniel L., Kooner, Jaspal S., Kraus, William E., Kritchevsky, Stephen, Kutalik, Zoltan, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Lerch, Markus M., Lewis, Joshua R., Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth J. F., Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N., Malkin, Ida, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Nethander, Maria, Newman, Anne B., O'Connell, Jeffery R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Peacock, Munro, Perola, Markus, Peters, Annette, Prince, Richard L., Psaty, Bruce M., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Rivadeneira, Fernando, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schipf, Sabine, Shin, Chan Soo, Smith, Albert V., Smith, Shad B., Soranzo, Nicole, Spector, Timothy D., Stancakova, Alena, Stefansson, Kari, Steinhagen-Thiessen, Elisabeth, Stolk, Lisette, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Thompson, Patricia, Thomson, Cynthia A., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Uitterlinden, Andre G., van Duijn, Cornelia M., van Schoor, Natasja M., Vandenput, Liesbeth, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Wareham, Nicholas J., Waterworth, Dawn, Weedon, Michael N., Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Zhou, Yanhua, Nielson, Carrie M., Harris, Tamara B., Demissie, Serkalem, Kiel, Douglas P., Ohlsson, Claes, Karasik, David, Zillikens, M. Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Ines, Bennett, David A., Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B., Broer, Linda, Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A., Cawthon, Peggy M., Chambers, John C., Chen, Zhao, Cho, Nam H., Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R., de Groot, Lisette C. P. G. M., De Jager, Phillip L., Demuth, Ilja, Diatchenko, Luda, Econs, Michael J., Eiriksdottir, Gudny, Enneman, Anke W., Eriksson, Joel, Eriksson, Johan G., Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J., Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelainen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koller, Daniel L., Kooner, Jaspal S., Kraus, William E., Kritchevsky, Stephen, Kutalik, Zoltan, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Lerch, Markus M., Lewis, Joshua R., Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth J. F., Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N., Malkin, Ida, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellstrom, Dan, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Nethander, Maria, Newman, Anne B., O'Connell, Jeffery R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Peacock, Munro, Perola, Markus, Peters, Annette, Prince, Richard L., Psaty, Bruce M., Raikkonen, Katri, Ralston, Stuart H., Ripatti, Samuli, Rivadeneira, Fernando, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schipf, Sabine, Shin, Chan Soo, Smith, Albert V., Smith, Shad B., Soranzo, Nicole, Spector, Timothy D., Stancakova, Alena, Stefansson, Kari, Steinhagen-Thiessen, Elisabeth, Stolk, Lisette, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Thompson, Patricia, Thomson, Cynthia A., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Uitterlinden, Andre G., van Duijn, Cornelia M., van Schoor, Natasja M., Vandenput, Liesbeth, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Wareham, Nicholas J., Waterworth, Dawn, Weedon, Michael N., Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Yerges-Armstrong, Laura M., Yu, Lei, Zhang, Weihua, Zhao, Jing Hua, Zhou, Yanhua, Nielson, Carrie M., Harris, Tamara B., Demissie, Serkalem, Kiel, Douglas P., and Ohlsson, Claes

Abstract

Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass. Objectives: To determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci. Methods: We performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n = 38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age(2), and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat mass as a percentage of body mass; Model 3 adjustment for fat mass in kilograms). Results: Seven single-nucleotide polymorphisms (SNPs) in separate loci, including one novel LM locus (TNRC6B), were successfully replicated in an additional 47,227 individuals from 29 cohorts. Based on the strengths of the associations in Model 1 vs Model 3, we divided the LM loci into those with an effect on both lean mass and fat mass in the same direction and refer to those as "sumo wrestler" loci (FTO and MC4R). In contrast, loci with an impact specifically on LMwere termed "body builder" loci (VCAN and ADAMTSL3). Using existing available genome-wide association study databases, LM increasing alleles of SNPs in sumo wrestler loci were associated with an adverse metabolic profile, whereas LM increasing alleles of SNPs in "body builder" loci were associated with metabolic protection. Conclusions: In conclusion, we identified one novel LM locus (TNRC6B). Our results suggest that a genetically determined increase in lean mass might exert either harmful or protective effects on metabolic traits, depending on its relation to fat mass.

Published
2019
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215. Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

Author

Hepp, Nicola, Frederiksen, Anja Lisbeth, Dunø, Morten, Jørgensen, Niklas Rye, Langdahl, Bente Lomholt, Vedtofte, Poul, Hove, Hanne B., Hindsø, Klaus, Jensen, Jens-Erik Beck, Hepp, Nicola, Frederiksen, Anja Lisbeth, Dunø, Morten, Jørgensen, Niklas Rye, Langdahl, Bente Lomholt, Vedtofte, Poul, Hove, Hanne B., Hindsø, Klaus, and Jensen, Jens-Erik Beck

Abstract

Pycnodysostosis (PYCD) is a rare recessive inherited skeletal disease, characterized by short stature, brittle bones, and recurrent fractures, caused by variants in the Cathepsin K encoding gene that leads to impaired osteoclast-mediated bone resorption. Hypophosphatasia (HPP) is a dominant or recessive inherited condition representing a heterogeneous phenotype with dental symptoms, recurrent fractures, and musculoskeletal problems. The disease results from mutation(s) in the tissue non-specific alkaline phosphate encoding gene with reduced activity of alkaline phosphatase and secondarily defective mineralization of bone and teeth. Here, we present the first report of a patient with the coexistence of PYCD and HPP. This patient presented typical clinical findings of PYCD, including short stature, maxillary hypoplasia, and sleep apnoea. However, the burden of disease was caused by over 30 fractures, whereupon most showed delayed healing and non-union. Biochemical analysis revealed suppressed bone resorption and low bone formation capacity. We suggest that the coexistence of impaired bone resorption and mineralization may explain the severe bone phenotype with poor fracture healing.

Published
2019

216. Bone Health in Patients with Type 2 Diabetes Treated by Roux-En-Y Gastric Bypass and the Role of Diabetes Remission

Author

Madsen, Lene Ring, Espersen, Rasmus, Ornstrup, Marie Juul, Jørgensen, Niklas Rye, Langdahl, Bente Lomholt, Richelsen, Bjørn, Madsen, Lene Ring, Espersen, Rasmus, Ornstrup, Marie Juul, Jørgensen, Niklas Rye, Langdahl, Bente Lomholt, and Richelsen, Bjørn

Abstract

BACKGROUND: Roux-en-Y gastric bypass (RYGB) has been associated with negative effects on bone. Whether this association is affected by pre-surgical type 2 diabetes (T2D) and surgically induced diabetes remission is unknown.METHODS: In this cross-sectional, matched cohort study 6 years after RYGB, we investigated bone health in 96 individuals with body mass index (BMI) > 35 kg/m2 and T2D (stratified on current diabetes status) treated by RYGB 6 years earlier compared with 49 non-operated individuals with T2D matched with respect to sex, age, and current BMI. Main outcome measures were areal and volumetric bone mineral density (aBMD and vBMD), bone turnover, and odds ratio of osteoporosis/osteopenia.RESULTS: The RYGB group had lower hip (0.916 vs 1.010 g/cm2, p < 0.001), forearm (0.497 g/cm2 vs 0.554 g/cm2, p < 0.001) aBMD, (269.63 mg/cm3 vs 306.07 mg/cm3, p < 0.001) tibial, and radial (238.57 mg/cm3 vs 278.14 mg/cm3, p < 0.0001) vBMD than the control group. Relative to the control group, c-terminal cross-linked telopeptide, procollagen type I amino-terminal propeptide, and osteocalcin were 75%, 41%, and 72% higher in the RYGB group, respectively (all p < 0.001). Odds ratio for osteopenia/osteoporosis in operated individuals was 2.21 (95% CI 1.06; 4.79, p = 0.05). Overall, stratified analysis on current diabetes status did not alter these outcomes.CONCLUSIONS: Individuals with T2D treated by RYGB, compared to individuals with T2D of similar age and body composition not treated by RYGB, have lower BMD, lower bone strength, and increased levels of several bone turnover markers. Bone health was not associated with current diabetes status in the RYGB group.

Published
2019

217. Community-based football in men with prostate cancer:1-year follow-up on a pragmatic, multicentre randomised controlled trial

Author

Bjerre, Eik Dybboe, Petersen, Thomas Hindborg, Jørgensen, Anders Bojer, Johansen, Christoffer, Krustrup, Peter, Langdahl, Bente, Poulsen, Mads Hvid, Madsen, Søren Sørensen, Østergren, Peter Busch, Borre, Michael, Rørth, Mikael, Brasso, Klaus, Midtgaard, Julie, Bjerre, Eik Dybboe, Petersen, Thomas Hindborg, Jørgensen, Anders Bojer, Johansen, Christoffer, Krustrup, Peter, Langdahl, Bente, Poulsen, Mads Hvid, Madsen, Søren Sørensen, Østergren, Peter Busch, Borre, Michael, Rørth, Mikael, Brasso, Klaus, and Midtgaard, Julie

Abstract

BACKGROUND: Physical exercise has been shown to be effective in relation to fatigue, aerobic fitness, and lower body strength in men with prostate cancer. However, research into the clinically relevant effects of interventions conducted in heterogeneous patient populations and in real-life clinical practice settings is warranted. METHODS AND FINDINGS: We conducted a pragmatic, multicentre, parallel randomised controlled trial in 5 Danish urological departments. Recruitment began in May 2015, the first participant was randomised in June 2015, and the last participant was included in February 2017. In total, 214 men with prostate cancer were randomly assigned to either 6 months of free-of-charge football training twice weekly at a local club (football group [FG]) (n = 109) or usual care (usual care group [UG]) (n = 105), including brief information on physical activity recommendations at randomisation. Participants were on average 68.4 (SD 6.2) years old, 157 (73%) were retired, 87 (41%) were on castration-based treatment, 19 (9%) had received chemotherapy, and 41 (19%) had skeletal metastases at baseline. In this 1-year follow-up study, we evaluated the effects of community-based football training on the following outcomes: primary outcome, quality of life; secondary outcomes: continuation of football after 6 months, hip and lumbar spine bone mineral density (BMD), mental health score, fat and lean body mass, and safety outcomes, i.e., fractures, falls, and hospital admissions. Intention to treat (ITT) and per protocol (PP) analyses were conducted. No statistically significant between-group difference was observed in change in prostate-cancer-specific quality of life (ITT: 1.9 points [95% CI -1.9 to 5.8], p = 0.325; PP: 3.6 points [95% CI -0.9 to 8.2], p = 0.119). A statistically significant between-group difference was observed in change in total hip BMD, in favour of FG (0.007 g/cm2 [95% CI 0.004 to 0.013], p = 0.037). No differences were observed in change in l

Published
2019

218. The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes

Author

Hygum, Katrine, Starup-Linde, Jakob, Harslor, Torben, Jorgensen, Niklas Rye, Hartmann, Bolette, Holst, Jens Juul, Langdahl, Bente L., Hygum, Katrine, Starup-Linde, Jakob, Harslor, Torben, Jorgensen, Niklas Rye, Hartmann, Bolette, Holst, Jens Juul, and Langdahl, Bente L.

Abstract

Objective: Bone turnover has a diurnal variation influenced by food intake, incretin hormones, the sympathetic nervous system and osteocyte function. The aim of the study was to compare diurnal variation in bone turnover in patients with diabetes and controls. Design: A clinical 24-h study with patients with type 1 diabetes (n = 5), patients with type 2 diabetes (n = 5) and controls (n = 5). Methods: Inclusion criterion: age >50 years. Exclusion criteria: diseases/medication that affect bone metabolism or recent use of incretin-based drugs. We drew blood samples hourly during the day and every 3 h during the night. We served an identical diet on all study days. We used repeated-measures one-way ANOVA to compare the levels of the investigated markers, and we quantified the effect of time by comparing group mean standard deviations. Results: The bone formation marker procollagen type 1 N-terminal propeptide showed a significant interaction between time and group (P = 0.01), and the mean standard deviation was lower in patients with type 2 diabetes compared with controls (P = 0.04) and patients with type 1 diabetes (P = 0.02). Other markers of bone formation and resorption showed significant effect of time. Levels of glucagon-like peptide-2, glucose-dependent insulinotropic peptide and sclerostin only showed significant effect of time (all P values 0.01), but levels of sclerostin tended to being highest in type 2 diabetes and lowest in controls. Conclusions: The diurnal variation in bone formation is attenuated in patients with type 2 diabetes. This is not explained by changes in incretin hormone levels, but possibly mediated by sclerostin

Published
2019

219. Overview of treatment approaches to osteoporosis.

Author

Langdahl, Bente L.

Subjects
*BONE density, *OSTEOPOROSIS, *MOLECULAR pharmacology, *BONE diseases, *DIPHOSPHONATES, *BONE growth
Abstract

Efficient therapies are available for the treatment of osteoporosis. Anti-resorptive therapies, including bisphosphonates and denosumab, increase bone mineral density (BMD) and reduce the risk of fractures by 20-70%. Bone-forming or dual-action treatments stimulate bone formation and increase BMD more than the anti-resorptive therapies. Two studies have demonstrated that these treatments are superior to anti-resorptives in preventing fractures in patients with severe osteoporosis. Bone-forming or dual-action treatments should be followed by anti-resorptive treatment to maintain the fracture risk reduction. The BMD gains seen with bone-forming and dual-action treatments are greater in treatment-naïve patients compared to patients pretreated with anti-resorptive treatments. However, the antifracture efficacy seems to be preserved. Treatment failure will often lead to switch of treatment from orally to parentally administrated anti-resorptives treatment or from anti-resorptive to bone-forming or dual-action treatment. Osteoporosis is a chronic condition and therefore needs a long-term management plan with a personalized approach to treatment. LINKED ARTICLES: This article is part of a themed issue on The molecular pharmacology of bone and cancer-related bone diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.9/issuetoc. [ABSTRACT FROM AUTHOR]

Published
2021
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220. Effects of whey protein and dietary fiber intake on insulin sensitivity, body composition, energy expenditure, blood pressure, and appetite in subjects with abdominal obesity.

Author

Fuglsang-Nielsen, Rasmus, Rakvaag, Elin, Langdahl, Bente, Knudsen, Knud Erik Bach, Hartmann, Bolette, Holst, Jens Juul, Hermansen, Kjeld, and Gregersen, Søren

Subjects
OBESITY, APPETITE, BLOOD pressure, ENERGY metabolism, DIETARY fiber, BODY composition, INGESTION, BLOOD sugar, INSULIN, RANDOMIZED controlled trials, CROSSOVER trials, STATISTICAL sampling, INSULIN resistance, LONGITUDINAL method
Abstract

Background: Recently, we demonstrated that whey protein (WP) combined with low dietary fiber improved lipemia, a risk factor for cardiovascular disease in subjects with abdominal obesity. In the present study, we investigated the effects of intake of WP and dietary fiber from enzyme-treated wheat bran on other metabolic parameters of the metabolic syndrome.Methods: The study was a 12-week, double-blind, randomized, controlled, parallel intervention study. We randomized 73 subjects with abdominal obesity to 1 of 4 iso-energetic dietary interventions: 60 g per day of either WP hydrolysate or maltodextrin (MD) combined with high-fiber (HiFi; 30 g dietary fiber/day) or low-fiber (LoFi; 10 g dietary fiber/day) cereal products. We assessed changes in insulin sensitivity, gut hormones (GLP-1, GLP-2, GIP, and peptide YY), body composition, 24-h BP, resting energy expenditure and respiratory exchange ratio (RER), and appetite.Results: Sixty-five subjects completed the trial. Subjective hunger ratings were lower after 12 weeks of WP compared with MD, independent of fiber content (P = 0.02). We found no effects on ratings of satiety, fullness or prospective food consumption for either of the interventions. Intake of WP combined with LoFi increased the postprandial peptide YY response. There were no effects of WP or fiber on insulin sensitivity, body composition, energy expenditure, incretins, or 24-h BP.Conclusions: WP consumption for 12 weeks reduced subjective ratings of hunger in subjects with abdominal obesity. Neither WP nor dietary fiber from wheat bran affected insulin sensitivity, 24-h BP, gut hormone responses, body composition, or energy expenditure compared with MD and low dietary fiber. [ABSTRACT FROM AUTHOR]

Published
2021
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224. Non-parathyroid hypercalcemia associated with paraffin oil injection in 12 younger male bodybuilders

Author

Sølling, Anne Sophie Koldkjær, Tougaard, Birgitte, Harsløf, Torben, Langdahl, Bente, Kongsbak Brockstedt, Helle, Byg, Keld-Erik, Ivarsen, Per, Karstoft Ystrøm, Ina, Holden Mose, Frank, Lissel Isaksson, Gustaf, Steen Svarer Hansen, Morten, Nagarajah, Subagini, Ejersted, Charlotte, Bendstrup, Elisabeth, and Rejnmark, Lars

Abstract

INTRODUCTION: Injection of paraffin oil to augment muscles size is a troubling phenomenon known to cause a foreign-body reaction with formation of granulomas. In a few case-reports, long-term side effects have been reported in terms of hypercalcemia and renal failure.METHODS: We identified a case series of 12 male bodybuilders presenting with non-parathyroid hypercalcemia who previously had injected paraffin oil to increase muscles size.RESULTS: At admission, all patients had moderate to severe hypercalcemia with suppressed PTH levels and impaired renal function. Calcitriol levels were within the normal range or slightly elevated. Follow up measurements showed marked hypercalciuria with nearly normal levels of bone turnover markers. A correlation was found between levels of peptidyl-dipeptidase and calcitriol (R=0.812, p= 0.050). Treatment with antiresorptive agents seemed less effective than glucocorticoids, which resulted in a significantly lowering of ionized calcium levels and improved renal function, although no patients were cured by this treatment. Immunosuppression with azathioprine or mycophenolate may have a glucocorticoid-saving effect. One patient had surgery with removal of affected muscle tissue, without any apparent effect on plasma calcium levels.CONCLUSION: The hypercalcemia and associated hypercalciuria seems to be due to an intestinal hyperabsorption of calcium. It remains to be elucidated, whether an increased calcitriol synthesis within granulomas is the only (main) mechanism by which intestinal calcium absorption is increased. Glucocorticoids seem most appropriate as the first choice for treatment. Bodybuilders should be warned against use of intramuscular oil injections (and other substances), as this may have severe adverse health consequences.

Published
2018
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225. Erratum:Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (Nature Communications (2017) 8:80 DOI: 10.1038/s41467-017-00031-7)

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie A M, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline S L, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen C J, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Räikkönen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin M A, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances M K, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Döring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J F, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P

Subjects
Published Erratum
Abstract

The previously published version of this Article contained typographical errors in the spelling of the author names Stephen C. J. Parker and H.-Erich Wichmann, which were incorrectly given as Stephan Parker and H.-Erich Wichman, respectively. Furthermore, Affiliation 53 was incorrectly given as 'Research Group on Geriatrics, The Berlin Aging Study II, ChariteUniversitätsmedizin Berlin, Berlin 13353, Germany', Affiliation 66 was incorrectly given as 'Department of Botany & Plant Sciences, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA', and Affiliation 152 was incorrectly given as 'Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA'. These errors have been corrected in the PDF and HTML versions of the Article.

Published
2017
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227. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (vol 8, 80, 2017)

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltan, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Zhao, Jing Hua, Zhang, Weihua, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Ines, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Obanda, Natalia Campos, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Choi, Hyung Jin, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpelanen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Osten, Lorentzon, Mattias, Luben, Robert N, Maixner, William, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Hakan, Mellstrom, Dan, Melov, Simon, Michaelsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Newman, Anne, Nielson, Carrie M, O'Connell, Jeffrey R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Parker, Stephen CJ, Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L, Raikkonen, Katri, Ralston, Stuart H, Ripatti, Samuli, Robbins, John A, Rotter, Jerome I, Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E, Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Shin, Chan Soo, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stancakova, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A, Styrkarsdottir, Unnur, Swart, Karin MA, Tan, Sian-Tsung, Tarnopolsky, Mark A, Thompson, Patricia, Thomson, Cynthia A, Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J, Tuomilehto, Jaakko, van Schoor, Natasja M, Verma, Arjun, Vollenweider, Peter, Volzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N, Welch, Ryan, Wichmann, H-Erich, Widen, Elisabeth, Williams, Frances MK, Wilson, James F, Wright, Nicole C, Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C, Doring, Angela, van Duijn, Cornelia M, Econs, Michael J, Gudnason, Vilmundur, Kooner, Jaspal S, Psaty, Bruce M, Spector, Timothy D, Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, Andre G, Wareham, Nicholas J, Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth JF, Karasik, David, Harris, Tamara B, Ohlsson, Claes, and Kiel, Douglas P

Published
2017
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228. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

A correction to this article has been published and is linked from the HTML version of this article.

Published
2017

229. Greater Gains in Spine and Hip Strength for Romosozumab Compared With Teriparatide in Postmenopausal Women With Low Bone Mass

Author

Keaveny, Tony M., Crittenden, Daria B., Bolognese, Michael A., Genant, Harry K., Engelke, Klaus, Oliveri, María Beatriz, Brown, Jacques P., Langdahl, Bente L., Yan, Chris, Grauer, Andreas, and Libanati, Cesar

Subjects
TERIPARATIDE, purl.org/becyt/ford/3.3 [https], Salud Ocupacional, CIENCIAS MÉDICAS Y DE LA SALUD, ANABOLICS, Journal Article, Ciencias de la Salud, purl.org/becyt/ford/3 [https], OSTEOPOROSIS, ROMOSOZUMAB
Abstract

Romosozumab is a monoclonal antibody that inhibits sclerostin and has been shown to reduce the risk of fractures within 12 months. In a phase II, randomized, placebo-controlled clinical trial of treatment-naïve postmenopausal women with low bone mass, romosozumab increased bone mineral density (BMD) at the hip and spine by the dual effect of increasing bone formation and decreasing bone resorption. In a substudy of that trial, which included placebo and teriparatide arms, here we investigated whether those observed increases in BMD also resulted in improvements in estimated strength, as assessed by finite element analysis. Participants received blinded romosozumab s.c. (210 mg monthly) or placebo, or open-label teriparatide (20 μg daily) for 12 months. CT scans, obtained at the lumbar spine (n = 82) and proximal femur (n = 46) at baseline and month 12, were analyzed with finite element software (VirtuOst, O.N. Diagnostics) to estimate strength for a simulated compression overload for the spine (L1 vertebral body) and a sideways fall for the proximal femur, all blinded to treatment assignment. We found that, at month 12, vertebral strength increased more for romosozumab compared with both teriparatide (27.3% versus 18.5%; p = 0.005) and placebo (27.3% versus –3.9%; p < 0.0001); changes in femoral strength for romosozumab showed similar but smaller changes, increasing more with romosozumab versus teriparatide (3.6% versus –0.7%; p = 0.027), and trending higher versus placebo (3.6% versus −0.1%; p = 0.059). Compartmental analysis revealed that the bone-strengthening effects for romosozumab were associated with positive contributions from both the cortical and trabecular bone compartments at both the lumbar spine and hip. Taken together, these findings suggest that romosozumab may offer patients with osteoporosis a new bone-forming therapeutic option that increases both vertebral and femoral strength within 12 months. Fil: Keaveny, Tony M.. University of California at Berkeley; Estados Unidos Fil: Crittenden, Daria B.. Amgen Inc.; Estados Unidos Fil: Bolognese, Michael A.. Bethesda Health Research Center; Estados Unidos Fil: Genant, Harry K.. Synarc; Estados Unidos. University of California; Estados Unidos Fil: Engelke, Klaus. Universitat Erlangen-Nuremberg; Alemania. Institute of Medical Physics Erlangen Germany; Alemania Fil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Brown, Jacques P.. Laval University; Canadá Fil: Langdahl, Bente L.. University Aarhus; Dinamarca Fil: Yan, Chris. Amgen Ltd.; Reino Unido Fil: Grauer, Andreas. Amgen Inc.; Estados Unidos Fil: Libanati, Cesar. Union Chimique Belge; Bélgica

Published
2017
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230. Okklusion og temporomandibulær dysfunktion hos voksne med osteogenesis imperfecta

Author

Gjørup, Hans, Bendixen, Karina Haugaard, Hald, Jannie Dahl, Baad-Hansen, Lene, Schmidt, Malene, Harsløf, Torben, Langdahl, Bente Lomholt, and Haubek, Dorte

Subjects
stomatognathic diseases, stomatognathic system
Abstract

Osteogenesis imperfecta (OI) is a rare inherited disease characterized by fragile bones because of defective collagen synthesis. OI can be divided into mild OI (Silence type I) and moderate-severe OI (Silence type III-IV). The dental and skeletal aberrations of OI might influence the temporomandibular function. The aims of study were to assess the dental occlusion and the occurrence of temporomandibular disorders (TMD) in adults with OI and to carry out a comparison of occlusal traits and TMD according to severity of OI. All participants (n = 75) had mutation in COL1A, and they were classified with mild OI (n = 56) or moderate-severe OI (n = 19). Dental occlusion was assessed on clinical photos and 3D models. The participants were examined according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). Results. Mandibular overjet and posterior cross-bite were more prevalent in moderate-severe than in mild OI group (P < 0.050). Temporomandibular disorders and functional

Published
2017

231. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
Extracellular Matrix Proteins, 17-Hydroxysteroid Dehydrogenases, 1.1 Normal biological development and functioning, Quantitative Trait Loci, Human Genome, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Single Nucleotide, Aldehyde Oxidoreductases, Regulatory Elements, Phenotype, Versicans, ADAMTS Proteins, Thinness, Underpinning research, Body Composition, Insulin Receptor Substrate Proteins, Genetics, Humans, Transcriptional, Polymorphism, Genome-Wide Association Study
Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p

Published
2017

232. Kraniofacial morfologi og dental okklusion hos voksne med osteogenesis imperfecta:En sammenligning i forhold til sværhedsgrad af sygdommen

Author

Gjørup, Hans, Hald, Jannie Dahl, Harsløf, Torben, Langdahl, Bente Lomholt, and Haubek, Dorte

Subjects
nervous system, macromolecular substances
Abstract

AIMS: To compare craniofacial characteristics and variation in dental occlusion according to severity of osteogenesis imperfecta (OI). OI is a rare inherited disease with fragility of bone and teeth because of abnormalities in the formation of collagen. METHODS: A total of 73 patients with a genetically confirmed diagnosis of OI were recruited in the department of medical endocrinology at Aarhus Universityhospital. Standardized profile cephalograms were obtained in 68 patients. Cephalometric analyses were performed and cephalometric variables were compared according to OI-severity (54 OI type 1(mild) versus 14 OI type 3 or 4 (severe)). The comparison was performed by multiple linear regression analyses with the cephalometric variable as outcome variable adjusted for the effect of age, gender, and family clustering. Patients had clinical photos taken: overjet, overbite, crossbite and posterior open bite were assessed. Statistical analyses by Fischer`s exact test. RESULTS: In comparison with mildly affected patients, the severely affected patients had significantly (p

Published
2017

236. Disentangling the genetics of lean mass

Author

Karasik, David, primary, Zillikens, M Carola, additional, Hsu, Yi-Hsiang, additional, Aghdassi, Ali, additional, Akesson, Kristina, additional, Amin, Najaf, additional, Barroso, Inês, additional, Bennett, David A, additional, Bertram, Lars, additional, Bochud, Murielle, additional, Borecki, Ingrid B, additional, Broer, Linda, additional, Buchman, Aron S, additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos-Obando, Natalia, additional, Cauley, Jane A, additional, Cawthon, Peggy M, additional, Chambers, John C, additional, Chen, Zhao, additional, Cho, Nam H, additional, Choi, Hyung Jin, additional, Chou, Wen-Chi, additional, Cummings, Steven R, additional, de Groot, Lisette C P G M, additional, De Jager, Phillip L, additional, Demuth, Ilja, additional, Diatchenko, Luda, additional, Econs, Michael J, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W, additional, Eriksson, Joel, additional, Eriksson, Johan G, additional, Estrada, Karol, additional, Evans, Daniel S, additional, Feitosa, Mary F, additional, Fu, Mao, additional, Gieger, Christian, additional, Grallert, Harald, additional, Gudnason, Vilmundur, additional, Lenore, Launer J, additional, Hayward, Caroline, additional, Hofman, Albert, additional, Homuth, Georg, additional, Huffman, Kim M, additional, Husted, Lise B, additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Johnson, Toby, additional, Biffar, Reiner, additional, Jordan, Joanne M, additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O, additional, Klopp, Norman, additional, Kloth, Jacqueline S L, additional, Koller, Daniel L, additional, Kooner, Jaspal S, additional, Kraus, William E, additional, Kritchevsky, Stephen, additional, Kutalik, Zoltán, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L, additional, Lerch, Markus M, additional, Lewis, Joshua R, additional, Lill, Christina, additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Livshits, Gregory, additional, Ljunggren, Östen, additional, Loos, Ruth J F, additional, Lorentzon, Mattias, additional, Luan, Jian'an, additional, Luben, Robert N, additional, Malkin, Ida, additional, McGuigan, Fiona E, additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D, additional, Morris, Andrew P, additional, Mosekilde, Leif, additional, Nethander, Maria, additional, Newman, Anne B, additional, O'Connell, Jeffery R, additional, Oostra, Ben A, additional, Orwoll, Eric S, additional, Palotie, Aarno, additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Prince, Richard L, additional, Psaty, Bruce M, additional, Räikkönen, Katri, additional, Ralston, Stuart H, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Robbins, John A, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schipf, Sabine, additional, Shin, Chan Soo, additional, Smith, Albert V, additional, Smith, Shad B, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Stančáková, Alena, additional, Stefansson, Kari, additional, Steinhagen-Thiessen, Elisabeth, additional, Stolk, Lisette, additional, Streeten, Elizabeth A, additional, Styrkarsdottir, Unnur, additional, Swart, Karin M A, additional, Thompson, Patricia, additional, Thomson, Cynthia A, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J, additional, Uitterlinden, André G, additional, van Duijn, Cornelia M, additional, van Schoor, Natasja M, additional, Vandenput, Liesbeth, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, J Wareham, Nicholas, additional, Waterworth, Dawn, additional, Weedon, Michael N, additional, Wichmann, H-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M K, additional, Wilson, James F, additional, Wright, Nicole C, additional, Yerges-Armstrong, Laura M, additional, Yu, Lei, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhou, Yanhua, additional, Nielson, Carrie M, additional, Harris, Tamara B, additional, Demissie, Serkalem, additional, Kiel, Douglas P, additional, and Ohlsson, Claes, additional

Published
2019
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239. Sex Differences in the Association Between Bone Mineral Density and Coronary Artery Disease in Patients Referred for Cardiac Computed Tomography.

Author

Therkildsen, Josephine, Winther, Simon, Nissen, Louise, Jørgensen, Hanne S., Thygesen, Jesper, Ivarsen, Per, Frost, Lars, Isaksen, Christin, Langdahl, Bente L., Hauge, Ellen-Margrethe, and Böttcher, Morten

Abstract

Atherosclerosis and osteoporosis are both common and preventable diseases. Evidence supports a link between coronary artery disease (CAD) and low bone mineral density (BMD). This study aimed to assess the association between thoracic spine BMD and CAD in men and women with symptoms suggestive of CAD. This cross-sectional study included 1487 (mean age 57 years (range 40-80), 47% men) patients referred for cardiac computed tomography (CT). Agatston coronary artery calcium score (CACS), CAD severity (no, mild, moderate, and severe), vessel involvement (no, 1-, 2-, and 3/left main disease), and invasive measurements were evaluated. BMD of three thoracic vertebrae was measured using quantitative CT. We used the American college of radiology cut-off values for lumbar spine BMD to categorize patients into very low (<80 mg/cm3), low (80-120 mg/cm3), or normal BMD (>120 mg/cm3). BMD as a continuous variable was included in the linear regression analyses to assess associations between CACS (CACS=0, CACS 1- 399, and CACS ≥ 400) and BMD, and CAD severity and BMD. Significant lower BMD was present with increasing CACS and stenosis degree unadjusted. Multivariate linear regression analyses in women revealed a significant correlation between BMD and CACS groups (β = −4.06, p<0.05), but no correlation between BMD and CAD severity (β = −1.59, p = 0.14). No association was found between BMD and CACS (β = −1.50, p = 0.36) and CAD severity (β = 0.07, p = 0.94) in men. BMD is significantly correlated to CACS after adjusting for confounders in women, but not in men, suggesting a possible sex difference in pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2021
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240. Effect of radiographic disease severity in high‐resolution quantitative computed tomography assessment of metacarpophalangeal joint erosion and cysts.

Author

Blavnsfeldt, Anne‐Birgitte Garm, Klose‐Jensen, Rasmus, Thygesen, Jesper, Therkildsen, Philip, Langdahl, Bente Lomholdt, Keller, Kresten Krarup, and Hauge, Ellen‐Margrethe

Subjects
COMPUTED tomography, METACARPOPHALANGEAL joint, ARTHRITIS, INTRACLASS correlation, NEUROCYSTICERCOSIS
Abstract

Aim: Bone erosions are the hallmark of rheumatoid arthritis (RA). High‐resolution peripheral quantitative computed tomography (HR‐pQCT) enables 3‐dimensional visualization of arthritic bone erosions at a high resolution. However, the degree of erosive disease could influence the reliability of HR‐pQCT evaluation. We aim to assess the intra‐ and inter‐reader variability of identification of erosions in the metacarpophalangeal (MCP) joints using HR‐pQCT in healthy controls and patients with RA, stratified according to van der Heijde‐modified Sharp Score (HSS) of radiographic erosions. Method: We analyzed HR‐pQCT images from 78 patients with RA and 25 healthy controls. Patients were allocated to one of three groups of mild, moderate or severe disease according to HSS of MCP joints 2 and 3. Total HR‐pQCT scans were analyzed twice in random order by three experienced readers, blinded to group distribution. The number of cortical interruptions and their classification as either erosions or cysts according to predefined criteria were recorded. Intraclass correlation coefficients (ICC) for cortical interruptions, erosions and cysts were calculated for each group using a 2‐way random‐effects model for inter‐reader ICC and a 2‐way mixed‐effects model for intra‐reader ICC. Results: The intra‐ and inter‐reader ICC were good to moderate for cortical interruptions and moderate for erosions throughout disease severity groups. The ICCs for the identification of cysts decreased with increasing degree of erosive disease. Conclusion: The detection of cortical interruptions is only minimally affected by the degree of erosive damage, whereas the distinction between erosions and cysts is more complex in patients with extensive erosive disease. [ABSTRACT FROM AUTHOR]

Published
2021
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243. Real-world effectiveness of teriparatide on fracture reduction in patients with osteoporosis and comorbidities or risk factors for fractures: Integrated analysis of 4 prospective observational studies

Author

Langdahl, Bente L., primary, Silverman, Stuart, additional, Fujiwara, Saeko, additional, Saag, Ken, additional, Napoli, Nicola, additional, Soen, Satoshi, additional, Enomoto, Hiroyuki, additional, Melby, Thomas E., additional, Disch, Damon P., additional, Marin, Fernando, additional, and Krege, John H., additional

Published
2018
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245. Leif Mosekilde

Author

Rejnmark, Lars, primary, Brixen, Kim, additional, Kassem, Moustapha, additional, Hermann, Pernille, additional, Vestergaard, Peter, additional, Eriksen, Erik Fink, additional, Bollerslev, Jens, additional, Nielsen, Henning K, additional, Charles, Peder, additional, and Langdahl, Bente, additional

Published
2018
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246. Reduction of Hip and Other Fractures in Patients Receiving Teriparatide in Real-World Clinical Practice: Integrated Analysis of Four Prospective Observational Studies

Author

Silverman, Stuart, primary, Langdahl, Bente L., additional, Fujiwara, Saeko, additional, Saag, Ken, additional, Napoli, Nicola, additional, Soen, Satoshi, additional, Enomoto, Hiroyuki, additional, Melby, Thomas E., additional, Disch, Damon P., additional, Marin, Fernando, additional, and Krege, John H., additional

Published
2018
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250. Effects of Teriparatide in Patients with Osteoporosis in Clinical Practice: 42-Month Results During and After Discontinuation of Treatment from the European Extended Forsteo® Observational Study (ExFOS)

Author

Napoli, Nicola, primary, Langdahl, Bente. L., additional, Ljunggren, Östen, additional, Lespessailles, Eric, additional, Kapetanos, George, additional, Kocjan, Tomaz, additional, Nikolic, Tatjana, additional, Eiken, Pia, additional, Petto, Helmut, additional, Moll, Thomas, additional, Lindh, Erik, additional, and Marin, Fernando, additional

Published
2018
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