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1,786 results on '"Lai, B."'

211. Changes of the phagosomal elemental concentrations by Mycobacterium tuberculosis Mramp

Author

Wagner, D., Maser, J., Morić, Ivana, Boechat, N., Vogt, S., Gicquel, B., Lai, B., Reyrat, J.-M., Bermudez, L., Wagner, D., Maser, J., Morić, Ivana, Boechat, N., Vogt, S., Gicquel, B., Lai, B., Reyrat, J.-M., and Bermudez, L.

Abstract

Pathogenic mycobacteria survive within phagosomes which are thought to represent a nutrient-restricted environment. Divalent cation transporters of the Nramp family in phagosomes and mycobacteria (Mramp) may compete for metals that are crucial for bacterial survival. The elemental concentrations in phagosomes of macrophages infected with wild-type Mycobacterium tuberculosis (M. tuberculosis strain H37Rv) and a M. tuberculosis Mramp knockout mutant (Mramp-KO), derived from a clinical isolate isogenic to the strain MT103, were compared. Time points of 1 and 24 h after infection of mouse peritoneal macrophages (bcgS) were compared in both cases. Increased concentrations of P, Ni and Zn and reduced Cl concentration in Mramp-KO after 1 h of infection were observed, compared to M. tuberculosis vacuoles. After 24 h of infection, significant differences in the P, Cl and Zn concentrations were still present. The Mramp-KO phagosome showed a significant increase of P, Ca, Mn, Fe and Zn concentrations between 1 and 24 h after infection, while the concentrations of K and Ni decreased. In the M. tuberculosis vacuole, the Fe concentration showed a similar increase, while the Cl concentration decreased. The fact that the concentration of several divalent cations increased in the Mramp-KO strain suggests that Mramp may have no impact on the import of these divalent cations into the mycobacterium, but may function as a cation efflux pump. The concordant increase of Fe concentrations within M. tuberculosis, as well as within the Mramp-KO vacuoles, implies that Mramp, in contrast to siderophores, might not be important for the attraction of Fe and its retention in phagosomes of unstimulated macrophages.

Published
2005

214. 2D/3D Trace Elemental Mapping of Frozen-hydrated Biomaterials using the Bionanoprobe

Author

Chen, S., primary, Lai, B., additional, Roehrig, C., additional, Maser, J., additional, Shu, D., additional, Finney, L., additional, Gleber, S., additional, Jin, Q., additional, Vogt, S., additional, Flachenecker, C., additional, Hornberger, B., additional, Paunesku, T., additional, Woloschak, G., additional, VonOsinski, J., additional, Bolbat, M., additional, Brister, K., additional, and Jacobsen, C., additional

Published
2012
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221. Magnetic field application or mechanical stimulation viamagnetic microparticles does not enhance chondrogenesis in mesenchymal stem cell sheetsElectronic supplementary information (ESI) available: Modeling of forces on a magnetic particle; data from supplementary experiments of hMSC sheets without and with magnetic particles stimulated by magnetic fields. See DOI: 10.1039/c7bm00061h

Author

Dikina, A. D., Lai, B. P., Cao, M., Zborowski, M., and Alsberg, E.

Abstract

Using a novel magnetic field bioreactor, this work evaluated the chondrogenesis of scaffold-free human mesenchymal stem cell sheets in response to static and variable magnetic fields, as well as mechanical stimulation via4.4 μm magnetic particles. Neither static nor variable magnetic fields generated by 1.44–1.45 T permanent magnets affected cartilage formation. Notably, magnetic field-induced mechanical stimulation by magnetic particles, which applied forces to the cells and ECM statically (4.39 pN) or cyclically (1.06–63.6 pN; 16.7 mHz), also did not affect cartilage formation.

Published
2017
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229. A Multimodal Nanocomposite for Biomedical Imaging

Author

Wu, A., primary, Paunesku, T., additional, Zhang, Z., additional, Vogt, S., additional, Lai, B., additional, Maser, J., additional, Yaghmai, V., additional, Li, D., additional, Omary, R. A., additional, Woloschak, G. E., additional, McNulty, Ian, additional, Eyberger, Catherine, additional, and Lai, Barry, additional

Published
2011
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231. Increased Cortical Excitability: A Mechanism for Alcohol Withdrawal Symptoms? (P07.145)

Author

Alan Lai B. Eng, Radwa A.B. Badawy, Mark J. Cook, Jon Currie, Amanda Norman, Simon Vogrin, and Richard A L Macdonell

Subjects
medicine.medical_specialty, Kindling, Pulse (signal processing), business.industry, medicine.medical_treatment, Alcohol, Inhibitory postsynaptic potential, Transcranial magnetic stimulation, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, medicine, Excitatory postsynaptic potential, Ingestion, Neurology (clinical), business, Balance (ability)
Abstract

Objective: We used transcranial magnetic stimulation (TMS) to investigate whether motor cortical excitability changes in relation to the amount of chronic alcohol ingestion. Background Experimental data suggesting that chronic alcohol exposure induces brain neuroadaptative changes within the excitatory and inhibitory neuronal circuits but this has never been proven. This because of the lack until recently of measuring the excitatory/inhibitory balance non-invasively in humans. Design/Methods: 43 participants divided according to the amount of alcohol they regularly consumed within the preceding 12 months into high, moderate and low risk groups were studied twice, (i) during regular pattern of alcohol consumption and (ii) after abstaining from alcohol for at least 24 hours. Motor threshold, short intracortical inhibition ([SICI] paired pulse TMS at 2, 5 ms interstimulus intervals [ISIs]), intracortical facilitation ([ICF] 10, 15 ms ISIs) and long intracortical inhibition ([LICI] 100- 300 ms ISIs) were measured on both occasions. The results were compared to those of 20 controls with no history of exposure to alcohol. Results: During regular alcohol consumption, there was reduced ICF (p Conclusions: Chronic alcohol consumption is associated with alterations within the intracortical excitatory and inhibitory systems. These changes may be a mechanism underlying alcohol withdrawal symptoms. Disclosure: Dr. Badawy has nothing to disclose. Dr. Cook has received research support from UCB Pharma. Dr. Vogrin has nothing to disclose. Dr. Norman has nothing to disclose. Dr. Currie has nothing to disclose.

Published
2012

233. Environmental Research at the Advanced Photon Source

Author

Kemner, K. M., primary, Boyanov, M. I., additional, Eng, P., additional, Fenter, P., additional, Heald, S., additional, Lai, B., additional, Lee, S. S., additional, Scheckel, K. G., additional, Skanthakumar, S., additional, Soderholm, L., additional, Sutton, S. R., additional, and Wilson, R. E., additional

Published
2010
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237. Bushfire impact on youth

Author

Yelland, C., primary, Robinson, P., additional, Lock, C., additional, La Greca, A. M., additional, Kokegei, B., additional, Ridgway, V., additional, and Lai, B., additional

Published
2010
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240. Non-destructive search for interstellar dust using synchrotron microprobes

Author

Westphal, A. J., primary, Allbrink, A., additional, Allen, C., additional, Bajt, S., additional, Bastien, R., additional, Bechtel, H., additional, Bleuet, P., additional, Borg, J., additional, Bowker, S., additional, Brenker, F., additional, Bridges, J., additional, Brownlee, D. E., additional, Burchell, M., additional, Burghammer, M., additional, Butterworth, A. L., additional, Campanile, A., additional, Cloetens, P., additional, Cody, G., additional, Ferroir, T., additional, Ferrari, K., additional, Floss, C., additional, Flynn, G. J., additional, Frank, D., additional, Gainsforth, Z., additional, Grün, E., additional, Harmer, M., additional, Hoppe, P., additional, Kearsley, A., additional, Kulkarni, S., additional, Lai, B., additional, Lemelle, L., additional, Leroux, H., additional, Lettieri, R., additional, Marchant, W., additional, McCreadie, B., additional, Nittler, L. R., additional, Ogliore, R., additional, Postberg, F., additional, Rigamonti, C., additional, Sandford, S. A., additional, Schmitz, S., additional, Silversmit, G., additional, Simionovici, A., additional, Sperry, G., additional, Srama, R., additional, Stadermann, F., additional, Stephan, T., additional, Stroud, R. M., additional, Susini, J., additional, Sutton, S., additional, Thompson, V., additional, Toucoulou, R., additional, Trieloff, M., additional, Tsou, P., additional, Tsuchiyama, A., additional, Tyliczszak, T., additional, Vekemans, B., additional, Vincze, L., additional, Warren, J., additional, Yahnke, T., additional, Zevin, D., additional, Zolensky, M. E., additional, Denecke, Melissa, additional, and Walker, Clive T., additional

Published
2010
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245. A monochromator based on W/C multilayers of 40 A layer spacing

Author

Smith, A, Riedel, C, Edwards, B, Savage, D, and Lai, B

Subjects
Instrumentation And Photography
Abstract

The design and preliminary performance data are presented for a monochromator based on two multilayer X-ray mirrors. The monochromator is based on mirrors with a d-spacing of 40 A and is designed to operate in the 5-75 A wavelength regime which can be varied by interchanging the mirrors with ones of different d-spacing. The multilayer mirrors are fabricated using sputter deposition and typically consist of 40 layer pairs of W and C. Except for W/Si, which shows 1-2 percent better reflectivities over the 7-40 A range but 4-10 percent poorer reflectivities for wavelengths longer than 40 A and shorter than 7 A, calculations performed using other combinations of materials generally show poorer reflectivities over the wavelength range of interest. Plans for a four-mirror version of the monochromator that will have increased resolution are also presented.

Published
1988

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