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The role of the cerebellum in motor control has been investigated extensively, but its contribution to the muscle pattern organization underlying goal-directed movements is still not fully understood. Muscle synergies may be used to characterize multimuscle pattern organization irrespective of time (spatial synergies), in time irrespective of the muscles (temporal synergies), and both across muscles and in time (spatiotemporal synergies). The decomposition of muscle patterns as combinations of different types of muscle synergies offers the possibility to identify specific changes due to neurological lesions. In this study, we recorded electromyographic activity from 13 shoulder and arm muscles in subjects with cerebellar ataxias (CA) and in age-matched healthy subjects (HS) while they performed reaching movements in multiple directions. We assessed whether cerebellar damage affects the organization of muscle patterns by extracting different types of muscle synergies from the muscle patterns of each HS and using these synergies to reconstruct the muscle patterns of all other participants. We found that CA muscle patterns could be accurately captured only by spatial muscle synergies of HS. In contrast, there were significant differences in the reconstruction R2 values for both spatiotemporal and temporal synergies, with an interaction between the two synergy types indicating a larger difference for spatiotemporal synergies. Moreover, the reconstruction quality using spatiotemporal synergies correlated with the severity of impairment. These results indicate that cerebellar damage affects the temporal and spatiotemporal organization, but not the spatial organization, of the muscle patterns, suggesting that the cerebellum plays a key role in shaping their spatiotemporal organization.NEW & NOTEWORTHY In recent studies, the decomposition of muscle activity patterns has revealed a modular organization of the motor commands. We show, for the first time, that muscle patterns of subjects with cerebellar damage share with healthy controls spatial, but not temporal and spatiotemporal, modules. Moreover, changes in spatiotemporal organization characterize the severity of the subject's impairment. These results suggest that the cerebellum has a specific role in shaping the spatiotemporal organization of the muscle patterns.

Mature locomotion involves modular spinal drives generating a set of fundamental patterns of motoneuron activation, each timed at a specific phase of locomotor cycles and associated with a stable muscle synergy. How locomotor modules develop and to what extent they depend on prior experience or intrinsic programs remains unclear. To address these issues, we herein leverage the presence at birth of two types of locomotor-like movements, spontaneous kicking and weight-bearing stepping. The former is expressed thousands of times in utero and postnatally, whereas the latter is elicited de novo by placing the newborn on the ground for the first time. We found that the neuromuscular modules of stepping and kicking differ substantially. Neonates kicked with an adult-like number of temporal activation patterns, which lacked a stable association with systematic muscle synergies across movements. However, on the ground neonates stepped with fewer temporal patterns but all structured in stable synergies. Since kicking and ground-stepping coexist at birth, switching between the two behaviors may depend on a dynamic reconfiguration of the underlying neural circuits as a function of sensory feedback from surface contact. We tracked the development of ground-stepping in 4- to 48-mo-old infants and found that, after the age of 6 mo, the number of temporal patterns increased progressively, reaching adult-like conformation only after independent walking was established. We surmise that mature locomotor modules may derive by combining the multiple patterns of repeated kicking, on the one hand, with synergies resulting from fractionation of those revealed by sporadic weight-bearing stepping, on the other hand.

To support the deployment of DEMO wall protection strategy, the development of comprehensive analyses is essential to understand the implications of transient perturbations on the plasma shape control and on the vertical stability, some of the most critical aspects to be considered in elongated plasmas. Therefore, the design activities of the DEMO limiter structures need the deep understanding of the effects induced by transient plasma perturbations coupled with one of the most severe load conditions occurring in tokamaks, the Vertical Displacement Event (VDE). Since Electromagnetic (EM) loads during VDE phases are among the DEMO limiters design drivers, this study focuses on predictive simulations of the final plasma position and of EM loads following a VDE. For this purpose, a multi-tokamaks study supported by the construction of an inter-machine database containing experimental transient plasma perturbations and VDEs from JET and ASDEX Upgrade (AUG) has been carried out. It aims at the characterization of some transient plasma perturbations that may lead to high control efforts by the vertical stability system in terms of variations of the plasma internal parameters and vertical displacements. Consequently, such experimental transient plasma perturbations have been properly scaled to DEMO reference geometries with different magnetic configurations, to be simulated in terms of plasma dynamical behaviour by means of MAXFEA code. Finally, initial predictive EM loads on DEMO limiter structures will be discussed in the case of VDEs following plasma perturbations.

Aims We present an innovative method based on haptics for the evaluation of the sense of touch in the hand, in people affected by type 1 diabetes. Methods Forty individuals affected by diabetes and 20 healthy controls took part in the study; the diabetes group was further divided into two subgroups based on vibration sensitivity in the lower limb. By means of a novel haptic device, tactile sensitivity in the fingertip was measured as the ability of the participants to discriminate slip motion speed. Results Tactile sensitivity was significantly lower in individuals affected by diabetes as compared to controls. Depending on the subgroup, the difference from the controls was equal to 0.11 (95% CI from 0.029 to 0.186) and to 0.267 (95% CI from 0.198 to 0.336). Within the diabetes group, tactile sensitivity correlated with vibration sensitivity in the upper (p = 0.001) and lower limb (p = 0.003). A significant relationship between nerve conduction parameters and tactile sensitivity was found (p = 0.03). Finally, we combined the different predictors (clinical, vibratory and electroneurography data) by using cluster analysis; tactile sensitivity was found to be significantly different between different clusters (p = 0.004). Conclusions Early signs of tactile dysfunction in the hand were found in individuals affected by diabetes, even in absence of diabetic neuropathy. The protocol presented in this study is a promising tool for the assessment of tactile dysfunction in the hand in people affected by type 1 diabetes.

Terrestrial locomotion requires coordinated bilateral activation of limb muscles, with left–right alternation in walking or running, and synchronous activation in hopping or skipping. The neural mechanisms involved in interlimb coordination at birth are well known in different mammalian species, but less so in humans. Here, 46 neonates (of either sex) performed bilateral and unilateral stepping with one leg blocked in different positions. By recording EMG activities of lower-limb muscles, we observed episodes of left–right alternating or synchronous coordination. In most cases, the frequency of EMG oscillations during sequences of consecutive steps was approximately similar between the two sides, but in some cases it was considerably different, with episodes of 2:1 interlimb coordination and episodes of activity deletions on the blocked side. Hip position of the blocked limb significantly affected ipsilateral, but not contralateral, muscle activities. Thus, hip extension backward engaged hip flexor muscle, and hip flexion engaged hip extensors. Moreover, the sudden release of the blocked limb in the posterior position elicited the immediate initiation of the swing phase of the limb, with hip flexion and a burst of an ankle flexor muscle. Extensor muscles showed load responses at midstance. The variable interlimb coordination and its incomplete sensory modulation suggest that the neonatal locomotor networks do not operate in the same manner as in mature locomotion, also because of the limited cortical control at birth. These neonatal mechanisms share many properties with spinal mammalian preparations (i.e., independent pattern generators for each limb, and for flexor and extensor muscles, load, and hip position feedback). SIGNIFICANCE STATEMENT Bilateral coupling and reciprocal activation of flexor and extensor burst generators represent the fundamental mechanisms used by mammalian limbed locomotion. Considerable progress has been made in deciphering the early development of the spinal networks and left–right coordination in different mammals, but less is known about human newborns. We compared bilateral and unilateral stepping in human neonates, where cortical control is still underdeveloped. We found neonatal mechanisms that share many properties with spinal mammalian preparations (i.e., independent pattern generators for each limb, the independent generators for flexor and extensor muscles, load, and hip-position feedback. The variable interlimb coordination and its incomplete sensory modulation suggest that the human neonatal locomotor networks do not operate in the same manner as in mature locomotion.

Reseña del libro de Leandro Losada Política y vida pública. Argentina (1930 - 1943).

Overarm throwing is a fundamental human skill. Since paleolithic hunter-gatherer societies, the ability of throwing played a key role in brain and body co-evolution. For decades, throwing skill acquisition has been the subject of developmental and gender studies. However, due to its complex multijoint nature, whole body throwing has found little space in quantitative studies of motor behavior. In this study we examined how overarm throwing varies within and between individuals in a sample of untrained adults. To quantitatively compare whole body kinematics across throwing actions, we introduced a new combination of spatiotemporal principal component, linear discrimination, and clustering analyses. We found that the identity and gender of a thrower can be robustly inferred by the kinematics of a single throw, reflecting the characteristic features in individual throwing strategies and providing a quantitative ground for the well-known differences between males and females in throwing behavior. We also identified four main classes of throwing strategies, stable within individuals and resembling the main stages of throwing proficiency acquisition during motor development. These results support earlier proposals linking interindividual and gender differences in throwing, with skill acquisition interrupted at different stages of the typical developmental trajectory of throwing motor behavior. NEW & NOTEWORTHY Unconstrained throwing, because of its complexity, received little attention in quantitative motor control studies. By introducing a new approach to analyze whole body kinematics, we quantitatively characterized gender effects, interindividual differences, and common patterns in nontrained throwers. The four throwing styles identified across individuals resemble different stages in the acquisition of throwing skills during development. These results advance our understanding of complex motor skills, bridging the gap between motor control, motor development, and sport science.

Acute kidney injury (AKI), closely related to increased mortality, involved 15–20% of hospitalized patients with higher incidence, with about 50% in the intensive care unit (ICU) [...]

Amputation of a lower limb implies a re-organization in the strategies used to reach a stable walking pattern. The planar covariation law of elevation angles is a well-defined low-dimensional description of the kinematics of movement; according to this law, thigh, shank and foot elevation angle co-vary on a plane, defining a typical gait loop. However, a robust biomechanical interpretation of the outcomes of its related analysis is still missing. In this work, we tested the planar covariation law on a group of 14 trans-femoral amputees, comparing the results with the ones related to 12 healthy people. Moreover, by adopting a common covariance plane for all the subjects, we checked whether the projection of the original elevation angles on this plane is able to yield biomechanically meaningful information on the control of prosthetic gait. A common plane was able to describe the coordination of lower limb elevation angles in all subjects; on this plane, most of the differences among populations were identified on the time course of one principal component.

Prosthetic gait implies the use of compensatory motor strategies, including alterations in gait biomechanics and adaptations in the neural control mechanisms adopted by the central nervous system. Despite the constant technological advancements in prostheses design that led to a reduction in compensatory movements and an increased acceptance by the users, a deep comprehension of the numerous factors that influence prosthetic gait is still needed. The quantitative prosthetic gait analysis is an essential step in the development of new and ergonomic devices and to optimize the rehabilitation therapies. Nevertheless, the assessment of prosthetic gait is still carried out by a heterogeneous variety of methodologies, and this limits the comparison of results from different studies, complicating the definition of shared and well-accepted guidelines among clinicians, therapists, physicians, and engineers. This perspective article starts from the results of a project funded by the Italian Worker's Compensation Authority (INAIL) that led to the generation of an extended dataset of measurements involving kinematic, kinetic, and electrophysiological recordings in subjects with different types of amputation and prosthetic components. By encompassing different studies published along the project activities, we discuss the specific information that can be extracted by different kinds of measurements, and we here provide a methodological perspective related to multimodal prosthetic gait assessment, highlighting how, for designing improved prostheses and more effective therapies for patients, it is of critical importance to analyze movement neural control and its mechanical actuation as a whole, without limiting the focus to one specific aspect.

We have recently provided evidence that cerebellar damage affects the spatiotemporal but not the spatial organization of the muscle patterns, suggesting that the cerebellum plays a key role in shaping their spatiotemporal organization. Here we show that the reconstruction of muscle patterns using spatiotemporal muscle synergies from healthy subjects unveils specific features in the muscle patterns of individuals with cerebellar ataxia. These results suggest a prediction power of time-varying muscle synergies that may provide novel markers of disease state after cerebellar damage. Understanding the changes in the modular organization of the motor system after neurological lesions is highly relevant for upper limb rehabilitation. Identification of an “abnormal” EMG feature in cerebellar disorders may have important clinical applications, because it may lead to the development of novel objective and quantitative indicators of motor impairment directly related to the specific pathophysiology.

Several neurological, metabolic and psychological conditions may lead to tactile dysfunctions. Quantitative Sensation Tests (QST) are currently available for the assessment of tactile sensitivity, including light touch testing, monofilament tests, and vibration-based tests. However, standard QSTs display a high intra- and inter-individual variability. To this end, we developed new interface that generates 2D motion of a contact plate, provides hand and finger tracking, and measures contact force and torque. Due to these multiple features, the device can be a powerful tool for the evaluation of touch in both, active and passive tasks.