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706 results on '"Løchen, Maja-Lisa"'

201. Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population

Author

Eriksen, Bjørn Odvar, primary, Løchen, Maja-Lisa, additional, Arntzen, Kjell Arne, additional, Bertelsen, Geir, additional, Winther Eilertsen, Britt-Ann, additional, von Hanno, Therese, additional, Herder, Marit, additional, Jenssen, Trond Geir, additional, Mathisen, Ulla Dorte, additional, Melsom, Toralf, additional, Njølstad, Inger, additional, Solbu, Marit D., additional, and Mathiesen, Ellisiv B., additional

Published
2015
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204. Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø Study 1979-2016.

Author

Arnesdatter Hopstock, Laila, Harald Bønaa, Kaare, Eggen, Anne Elise, Grimsgaard, Sameline, Jacobsen, Bjarne K., Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Njølstad, Inger, and Wilsgaard, Tom

Abstract

Objectives Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studies show a cholesterol decline in recent decades but lack data to follow individuals born in different decades throughout life. Methods We investigated changes in age-specific and birth cohort-specific total cholesterol (TC) levels in 43 710 women and men born in 1905-1977 (aged 20-95 years at screening) in the population-based Tromsø Study. Fifty-nine per cent of the participants had more than one and up to six repeated TC measurements during 1979-2016. Linear mixed models were used to test for time trends. Results Mean TC decreased during 1979-2016 in both women and men and in all age groups. The decrease in TC in age group 40-49 years was 1.2 mmol/L in women and 1.0 mmol/L in men. Both the 80th and the 20th percentile of the population TC distribution decreased in both sexes and all age groups. Longitudinal analysis showed that TC increased with age to a peak around middle age followed by a decrease. At any given age, TC significantly decreased with increase in year born. Lipid-lowering drug use was rare in 1994, increased thereafter, but was low (<3% in women and <5% in men) among those younger than 50 years in all surveys. Between 1994 and 2016, lipid-lowering drug treatment in individuals 50 years and older explained 21% and 28% of the decrease in TC levels in women and men, respectively. Conclusions We found a substantial decrease in mean TC levels in the general population between 1979 and 2016 in all age groups. In birth cohorts, TC increased with age to a peak around middle age followed by a decrease. [ABSTRACT FROM AUTHOR]

Published
2017
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205. A frameshift deletion in the sarcomere gene MYL4 causes early-onset familial atrial fibrillation.

Author

Gudbjartsson, Daniel F., Holm, Hilma, Sulem, Patrick, Masson, Gisli, Oddsson, Asmundur, Magnusson, Olafur Th., Saemundsdottir, Jona, Helgadottir, Hafdis Th., Helgason, Hannes, Johannsdottir, Hrefna, Gretarsdottir, Solveig, Gudjonsson, Sigurjon A., Njølstad, Inger, Løchen, Maja-Lisa, Baum, Larry, Ma, Ronald C.W., Sigfusson, Gunnlaugur, Kong, Augustine, Thorgeirsson, Guðmundur, and Sverrisson, Jon Th.

Abstract

Aims: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF. Methods and results; We sequenced the whole genomes of 8453 Icelanders and imputed genotypes of the 25.5 million sequence variants we discovered into 1799 Icelanders with early-onset AF (diagnosed before 60 years of age) and 337 453 controls. Each sequence variant was tested for association based on multiplicative and recessive inheritance models. We discovered a rare frameshift deletion in the myosin MYL4 gene (c.234delC) that associates with early-onset AF under a recessive mode of inheritance (allelic frequency¼0.58%). We found eight homozygous carriers of the mutation, all of whom had early-onset AF. Six of the homozygotes were diagnosed by the age of 30 and the remaining two in their 50s. Three of the homozygotes had received pacemaker implantations due to sick sinus syndrome, three had suffered an ischemic stroke, and one suffered sudden cardiac death. Conclusions: Through a population approach we found a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for early-onset AF. The finding may provide novel mechanistic insight into the pathophysiology of this complex arrhythmia. [ABSTRACT FROM AUTHOR]

Published
2017
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206. Red Cell Distribution Width Is Associated With Incident Myocardial Infarction in a General Population: The Tromsø Study

Author

Skjelbakken, Tove, primary, Lappegård, Jostein, additional, Ellingsen, Trygve S., additional, Barrett‐Connor, Elizabeth, additional, Brox, Jan, additional, Løchen, Maja‐Lisa, additional, Njølstad, Inger, additional, Wilsgaard, Tom, additional, Mathiesen, Ellisiv B., additional, Brækkan, Sigrid K., additional, and Hansen, John‐Bjarne, additional

Published
2014
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207. Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population

Author

Eriksen, Bjørn O., primary, Løchen, Maja-Lisa, additional, Arntzen, Kjell A., additional, Bertelsen, Geir, additional, Eilertsen, Britt-Ann W., additional, von Hanno, Therese, additional, Herder, Marit, additional, Jenssen, Trond G., additional, Mathisen, Ulla D., additional, Melsom, Toralf, additional, Njølstad, Inger, additional, Solbu, Marit D., additional, Toft, Ingrid, additional, and Mathiesen, Ellisiv B., additional

Published
2014
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209. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Author

Holmen, Oddgeir L, primary, Zhang, He, additional, Fan, Yanbo, additional, Hovelson, Daniel H, additional, Schmidt, Ellen M, additional, Zhou, Wei, additional, Guo, Yanhong, additional, Zhang, Ji, additional, Langhammer, Arnulf, additional, Løchen, Maja-Lisa, additional, Ganesh, Santhi K, additional, Vatten, Lars, additional, Skorpen, Frank, additional, Dalen, Håvard, additional, Zhang, Jifeng, additional, Pennathur, Subramaniam, additional, Chen, Jin, additional, Platou, Carl, additional, Mathiesen, Ellisiv B, additional, Wilsgaard, Tom, additional, Njølstad, Inger, additional, Boehnke, Michael, additional, Chen, Y Eugene, additional, Abecasis, Gonçalo R, additional, Hveem, Kristian, additional, and Willer, Cristen J, additional

Published
2014
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210. The Phosphodiesterase 8B Gene rs4704397 is Associated with Thyroid Function, Risk of Myocardial Infarction, and Body Height: The Tromsø Study

Author

Jorde, Rolf, primary, Schirmer, Henrik, additional, Wilsgaard, Tom, additional, Joakimsen, Ragnar Martin, additional, Mathiesen, Ellisiv Bøgeberg, additional, Njølstad, Inger, additional, Løchen, Maja-Lisa, additional, Figenschau, Yngve, additional, Svartberg, Johan, additional, Hutchinson, Moira Strand, additional, Kjærgaard, Marie, additional, Jørgensen, Lone, additional, and Grimnes, Guri, additional

Published
2014
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214. MINNEORD

Author

Løchen, Maja-Lisa, primary, Os, Ingrid, primary, Hagen, Egil, primary, Jenssen, Trond, primary, Eriksen, Bjørn Odvar, primary, Solbu, Marit Dahl, primary, Mathisen, Ulla Dorte, primary, and Paulssen, Eyvind J., primary

Published
2014
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219. Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: the Tromsø Study.

Author

Sharashova, Ekaterina, Wilsgaard, Tom, Mathiesen, Ellisiv B., Løchen, Maja-Lisa, Njølstad, Inger, and Brenn, Tormod

Subjects
ATRIAL fibrillation risk factors, MYOCARDIAL infarction risk factors, STROKE risk factors, BLOOD pressure, CARDIOVASCULAR diseases risk factors, CHOLESTEROL, CONFIDENCE intervals, FORECASTING, HEART beat, MORTALITY, RESEARCH funding, BODY mass index, PHYSICAL activity
Published
2016
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220. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

Author

Piepoli, Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie-Therese, Corrà, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Hobbs, F. D. Richard, Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, and Richter, Dimitrios J.

Published
2016
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222. Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Tromsø Study

Author

Jorde, Rolf, primary, Schirmer, Henrik, additional, Wilsgaard, Tom, additional, Joakimsen, Ragnar Martin, additional, Mathiesen, Ellisiv Bøgeberg, additional, Njølstad, Inger, additional, Løchen, Maja-Lisa, additional, Figenschau, Yngve, additional, Berg, Jens Petter, additional, Svartberg, Johan, additional, and Grimnes, Guri, additional

Published
2012
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227. Declining Incidence of Ischemic Stroke

Author

Vangen-Lønne, Anne M., Wilsgaard, Tom, Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, Inger, and Mathiesen, Ellisiv B.

Abstract

Supplemental Digital Content is available in the text.

Published
2017
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228. Guía ESC 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica

Author

Piepoli, Autores/Miembros del grupo de trabajo: Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie-Therese, Corrà, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Hobbs, F.D. Richard, Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, Richter, Dimitrios J., Sattar, Naveed, Smulders, Yvo, Tiberi, Monica, van der Worp, H. Bart, van Dis, Ineke, Verschuren, W.M. Monique, Binno, Contribuidor adicional: Simone, Backer, Revisores del documento: Guy De, Roffi, Marco, Aboyans, Victor, Bachl, Norbert, Bueno, Héctor, Carerj, Scipione, Cho, Leslie, Cox, John, Sutter, Johan De, Egidi, Günther, Fisher, Miles, Fitzsimons, Donna, Franco, Oscar H., Guenoun, Maxime, Jennings, Catriona, Jug, Borut, Kirchhof, Paulus, Kotseva, Kornelia, Lip, Gregory Y.H., Mach, François, Mancia, Giuseppe, Bermudo, Franz Martin, Mezzani, Alessandro, Niessner, Alexander, Ponikowski, Piotr, Rauch, Bernhard, Rydén, Lars, Stauder, Adrienne, Turc, Guillaume, Wiklund, Olov, Windecker, Stephan, and Zamorano, José Luis

Abstract

Las declaraciones de conflictos de intereses de los expertos participantes en el desarrollo de esta guía están disponibles en la página webde la ESC: www.escardio.org/guidelines

Published
2016
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229. Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study

Author

Toft, Ingrid, primary, Solbu, Marit, additional, Kronborg, Jens, additional, Mathisen, Ulla D., additional, Eriksen, Bjørn O., additional, Storhaug, Hilde, additional, Melsom, Toralf, additional, Løchen, Maja-Lisa, additional, Mathiesen, Ellisiv B., additional, Njølstad, Inger, additional, Wilsgaard, Tom, additional, and Brox, Jan, additional

Published
2011
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234. Anemia and the risk of non-vertebral fractures

Author

Jørgensen, Lone, primary, Skjelbakken, Tove, additional, Løchen, Maja-Lisa, additional, Ahmed, Luai, additional, Bjørnerem, Åshild, additional, Joakimsen, Ragnar, additional, and Jacobsen, Bjarne, additional

Published
2010
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235. Several common variants modulate heart rate, PR interval and QRS duration

Author

Holm, Hilma, primary, Gudbjartsson, Daniel F, additional, Arnar, David O, additional, Thorleifsson, Gudmar, additional, Thorgeirsson, Gudmundur, additional, Stefansdottir, Hrafnhildur, additional, Gudjonsson, Sigurjon A, additional, Jonasdottir, Aslaug, additional, Mathiesen, Ellisiv B, additional, Njølstad, Inger, additional, Nyrnes, Audhild, additional, Wilsgaard, Tom, additional, Hald, Erin M, additional, Hveem, Kristian, additional, Stoltenberg, Camilla, additional, Løchen, Maja-Lisa, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2010
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239. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke

Author

Gudbjartsson, Daniel F, primary, Holm, Hilma, additional, Gretarsdottir, Solveig, additional, Thorleifsson, Gudmar, additional, Walters, G Bragi, additional, Thorgeirsson, Gudmundur, additional, Gulcher, Jeffrey, additional, Mathiesen, Ellisiv B, additional, Njølstad, Inger, additional, Nyrnes, Audhild, additional, Wilsgaard, Tom, additional, Hald, Erin M, additional, Hveem, Kristian, additional, Stoltenberg, Camilla, additional, Kucera, Gayle, additional, Stubblefield, Tanya, additional, Carter, Shannon, additional, Roden, Dan, additional, Ng, Maggie C Y, additional, Baum, Larry, additional, So, Wing Yee, additional, Wong, Ka Sing, additional, Chan, Juliana C N, additional, Gieger, Christian, additional, Wichmann, H-Erich, additional, Gschwendtner, Andreas, additional, Dichgans, Martin, additional, Kuhlenbäumer, Gregor, additional, Berger, Klaus, additional, Ringelstein, E Bernd, additional, Bevan, Steve, additional, Markus, Hugh S, additional, Kostulas, Konstantinos, additional, Hillert, Jan, additional, Sveinbjörnsdóttir, Sigurlaug, additional, Valdimarsson, Einar M, additional, Løchen, Maja-Lisa, additional, Ma, Ronald C W, additional, Darbar, Dawood, additional, Kong, Augustine, additional, Arnar, David O, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2009
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245. Association between diastolic dysfunction and future atrial fibrillation in the Tromsø Study from 1994 to 2010.

Author

Tiwari, Sweta, Schirmer, Henrik, Jacobsen, Bjarne K., Hopstock, Laila A., Nyrnes, Audhild, Heggelund, Geir, Njølstad, Inger, Mathiesen, Ellisiv B., and Løchen, Maja-Lisa

Subjects
STRESS echocardiography, ATRIAL fibrillation risk factors, COHORT analysis, SYSTOLIC blood pressure, HEART rate monitoring, BODY mass index, PHYSIOLOGICAL effects of cholesterol
Abstract

Objective To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. Methods We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. Information concerning age, systolic blood pressure, height, heart rate, body mass index, total and high-density lipoprotein cholesterol, self-reported use of alcohol, smoking, coffee, physical activity, antihypertensive treatment, prevalent coronary heart disease, valvular heart disease, heart failure, hypertrophy, diabetes and palpitations were obtained at baseline. The outcome measure was clinical AF, documented by an ECG. Results AF was detected in 462 subjects (193 women). Mean age at baseline was 62.6 years. Incidence rate of clinical AF was 12.6 per 1000 personyears. In multivariable Cox proportional hazards regression analysis, moderately enlarged LA was associated with 60% (95% CI 1.2 to 2.0) increased risk of AF. Severely enlarged LA had HR for AF of 4.2 (95% CI 2.7 to 6.5) with p value for linear trend <0.001, and the association was similar in both sexes. Abnormal mitral Doppler flow adjusted for predictor variables did not show a statistically significant association with AF risk. However, when LA size was also adjusted for, the risk of AF increased by 30% (95% CI 1.0 to 1.6). Conclusions Our findings suggest that enlarged LA as a measure for diastolic dysfunction is a significant risk factor for AF in both sexes, and adding measures of abnormal diastolic flow increased the predictive ability significantly. [ABSTRACT FROM AUTHOR]

Published
2015
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246. The validity of self-reported information about hypertensive disorders of pregnancy in a population-based survey: the Tromsø Study.

Author

Falkegård, Marit, Schirmer, Henrik, Løchen, Maja‐Lisa, Øian, Pål, and Acharya, Ganesh

Subjects
HYPERTENSION in pregnancy, HYPERTENSION, PROTEINURIA, SELF-report inventories, TEST validity
Abstract

Objective To investigate the validity of self-reported information about hypertensive disorders in previous pregnancies among women participating in the fourth survey of the Tromsø Study. Design Retrospective cohort study with case-control design. Population Parous women participating in the fourth survey of the Tromsø Study. Methods Medical records including partograms of 200 randomly selected women who had answered positively to whether they had hypertension and/or proteinuria during one or more of their previous pregnancies (cases) and 200 women who had answered negatively (controls) were studied. The cases and controls were matched for age. The investigators were blinded to the allocation of cases and controls until data collection was finished. Main outcome measures Self-reported and actual prevalence of hypertensive pregnancy disorders and predictive value of self-reported hypertension and/or proteinuria in previous pregnancies. Results Clinical data were missing for 23.5% (94/400) of the participants (50 cases and 44 controls). A total of 80% (120/150) of cases and 57.1% (89/156) of controls had answered the question on whether or not they had high blood pressure and/or proteinuria during their pregnancies correctly (positive predictive value 0.800; negative predictive value 0.571). The proportion of false-positive cases declined with increasing age while the proportion of false-negative controls increased until 55 years of age. Conclusions We found good concordance between self-reported hypertension and/or proteinuria during previous pregnancies and actual clinical findings among the cases. However, there was a tendency towards under-reporting among controls. [ABSTRACT FROM AUTHOR]

Published
2015
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248. No large-effect low-frequency coding variation found for myocardial infarction.

Author

Holmen, Oddgeir L., Zhang, He, Zhou, Wei, Schmidt, Ellen, Hovelson, Daniel H., Langhammer, Arnulf, Løchen, Maja-Lisa, Ganesh, Santhi K., Mathiesen, Ellisiv B., Vatten, Lars, Platou, Carl, Wilsgaard, Tom, Chen, Jin, Skorpen, Frank, Dalen, Håvard, Boehnke, Michael, Abecasis, Goncalo R., Njølstad, Inger, Hveem, Kristian, and Willer, Cristen J.

Published
2014
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250. Ethnic difference in the prevalence of angina pectoris in Sami and non-Sami populations: the SAMINOR study.

Author

Broderstad, Ann Ragnhild, Eliassen, Bent-Martin, Graff-Iversen, Sidsel, Løchen, Maja-Lisa, and Melhus, Marita

Subjects
ETHNIC differences, CROSS-cultural differences, ETHNIC relations, ETHNIC groups, ANGINA pectoris
Abstract

Objective. To assess the population burden of angina pectoris symptoms (APS), self-reported angina and a combination of these, and explore potential ethnic disparity in their patterns. If differences in APS were found between Sami and non-Sami populations, we aimed at evaluating the role of established cardiovascular risk factors as mediating factors. Design. Cross-sectional population-based study. Methods. A health survey was conducted in 2003-2004 in areas with Sami and non-Sami populations (SAMINOR). The response rate was 60.9%. The total number for the subsequent analysis was 15,206 men and women aged 36-79 years (born 1925-1968). Information concerning lifestyle was collected by 2 selfadministrated questionnaires, and clinical examinations provided data on waist circumference, blood pressure and lipid levels. Results. This study revealed an excess of APS, self-reported angina and a combination of these in Sami relative to non-Sami women and men. After controlling for age, the odds ratio (OR) for APS was 1.42 (p><0.001) in Sami women and 1.62 (p<0.001) for men. When including relevant biomarkers and conventional risk factors, little change was observed.When also controlling for moderate alcohol consumption and leisure-time physical activity, the OR in women was reduced to 1.24 (p=0.06). Little change was observed in men. Conclusion. This study revealed an excess of APS, self-reported angina and a combination of these in Sami women and men relative to non-Sami women and men. Established risk factors explained little or none of the ethnic variation in APS. In women, however, less moderate alcohol consumption and leisure-time physical activity in Sami may explain the entire ethnic difference. [ABSTRACT FROM AUTHOR]

Published
2014
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