668 results on '"L, Monti"'
Search Results
202. [Surgical treatment of senile genital prolapse]
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R L, MONTI and J, ROSENVASSER
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Prolapse ,Humans ,Female ,Genitalia ,Genitalia, Female ,Genital Diseases, Female - Published
- 1954
203. ChemInform Abstract: STEREOCHEMIE UND MECHANISMUS DER PINAKOLTYP-UMLAGERUNGEN IN DER 1-PHENYL-4-TERT.-BUTYL-CYCLOHEXAN-REIHE
- Author
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Bruno Macchia, Pier Luigi Barili, Giancarlo Berti, L. Monti, and Franco Macchia
- Subjects
Chemistry ,General Medicine ,Medicinal chemistry - Abstract
Behandlung der zwei diastereomeren Epoxide (I) und der vier Diole (IV) mit Bortrifluorid -Ather-Komplex fuhrt jeweils zu einem Gemisch der stereoisomeren Cyclohexanone (II) und Cyclopentancarbaldehyde (III).
- Published
- 1970
204. [Muscular hyperplasia of the pampiniform plexus in varicocele]
- Author
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V, BALLI and L, MONTI
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Male ,Spermatic Cord ,Hyperplasia ,Varicocele ,Humans ,Veins - Published
- 1951
205. ChemInform Abstract: NUCLEOPHILE RK.-TEILNAHME VON HEXAMETHYLPHOSPHORTRIAMID BEI DER BROMIERUNG VON ALKENEN UND BEI DER SAEURE-KATALYSIERTEN RINGOEFFNUNG VON OXIRANEN
- Author
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Franco Macchia, Chiara Anselmi, L. Monti, Bruno Macchia, and C. Berti
- Subjects
Chemistry ,General Medicine ,Medicinal chemistry - Published
- 1972
206. [Harelip and cleft palate. Rational treatment. (Our experience)]
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L, MONTI, N, VEGA, A, SUGASTE, and P, DIAZ DE BEDOYA
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Cleft Palate ,Cleft Lip ,Digestive System Surgical Procedures - Published
- 1960
207. ChemInform Abstract: UMLAGERUNGEN VOM PINATEOLIN-TYP IN DER PHENYLCYCLO-HEXAN-REIHE, BEWEIS FUER UNTERSCHIEDE IN DEN RK.-MECHANISMEN VON EPOXIDEN EINERSEITS UND DEN ENTSPRECHENDEN DIOLEN UND HALOGENHYDRINEN ANDERERSEITS
- Author
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Giancarlo Berti, Bruno Macchia, L. Monti, and Franco Macchia
- Subjects
Chemistry ,Stereochemistry ,General Medicine - Published
- 1972
208. Above the modifications of the lymphatic tissue of the blind appendage of the rabbit grafted in an anomalous location
- Author
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C, ZAGNONI and L, MONTI
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Histological Techniques ,Humans ,Appendix - Published
- 1947
209. [Stenosis of the common bile duct due to malignant supra-ampullar pipilloma]
- Author
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L, MONTI
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Common Bile Duct ,Bile Duct Neoplasms ,Papilloma ,Humans ,Constriction, Pathologic - Published
- 1951
210. [Case of giant traumatic abscess of the left lobe of the liver]
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L, MONTI
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Liver Abscess ,Humans ,Abscess - Published
- 1952
211. Highlights of meiotic genes in Arabidopsis thaliana
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L. Monti, Domenico Carputo, C. Conicella, F. Consiglio, C., Conicella, F. Consiglio, ., Carputo, Domenico, and Monti, Luigi
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Genetics ,biology ,Arabidopsis ,Fertility ,Meiosis ,Mutants ,fungi ,Synapsis ,food and beverages ,biology.organism_classification ,Applied Microbiology and Biotechnology ,Plant reproduction ,Apomixis ,Arabidopsis thaliana ,Agronomy and Crop Science ,Molecular Biology ,Gene ,Cytokinesis ,Biotechnology - Abstract
Meiosis is a fascinating and complex phenomenon and, despite its central role in sexual plant reproduction, little is known on the molecular mechanisms involved in this process. We review the progress made in recent years using Arabidopsis thaliana mutants for isolating meiotic genes. In particular, emphasis is given on the description of mutants affecting either the regular commitment to meiosis, or the mechanisms of synapsis, recombination, and cytokinesis. We believe that the isolation of genes affecting some crucial meiotic events may represent the first step towards the practical use of meiotic genes in plant breeding. The introduction of deviations in the meiotic pathway into sexual crops will have important implications for the exploitation of apomixis and sexual polyploidization. Key words : Arabidopsis, meiosis, mutants, fertility. African Journal of Biotechnology Vol. 2 (12), pp.516-520, December 2003
212. New type of phosphorus compound by autocondensation of hexamethylphosphoric triamide
- Author
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F. Macchia, L. Monti, Chiara Anselmi, and B. Macchia
- Subjects
Hexamethylphosphoric Triamide ,chemistry.chemical_classification ,Chemistry ,Phosphorus ,Salt (chemistry) ,Organic chemistry ,chemistry.chemical_element ,Alkyl - Abstract
Hexamethylphosphoric triamide reacts with alkyl iodides to produce a salt of a new type for which the structure (Me2N)3P·O·P(O)(NMe2)2 I– has been established.
- Published
- 1971
213. Pinacol-type rearrangements in the phenylcyclohexane series: evidence for differences between the reaction mechanisms of epoxides and of the corresponding diols and halogenohydrins
- Author
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F. Macchia, B. Macchia, Giancarlo Berti, and L. Monti
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chemistry.chemical_classification ,Reaction mechanism ,Ketone ,Chemistry ,Stereochemistry ,Pinacol ,Organic Chemistry ,Epoxide ,Medicinal chemistry ,Aldehyde ,chemistry.chemical_compound ,Carbonium ion ,Reagent ,Phenyl group - Abstract
Boron trifluoride–ether complex in benzene rapidly converts (–)(S,S)-1,2-epoxy-1-phenylcyclohexane and the corresponding (–)-(S,S)-cis-1,2-diol and (+)-(R,S)-trans-1,2-diol into mixtures of 1-phenylcyclopentanecarbaldehyde and (–)-(S)-2-phenylcyclohexanone, while a slower secondary reaction transforms the aldehyde into the ketone. (–)-(S,S)-cis-2-Fluoro-2-phenylcyclohexanol, quantitatively formed from the epoxide with boron trifluoride–ether, is converted by the same reagent in benzene into the aldehyde and ketone. All the primary conversions into the ketone take place with a high optical yield, as expected for 1,2-hydride shifts. The large differences in the ketone–aldehyde ratios can be explained by assuming that, while the diols and fluorohydrin rearrange through open carbonium ions, the epoxide–aldehyde conversion takes place in a more concerted manner. A comparison with previous data on the same reaction applied to the corresponding diastereoisomeric 4-t-butyl derivatives strongly suggests that the diols and fluorohydrin react preferentially in their less stable conformations with an axial phenyl group.
- Published
- 1971
214. Stereochemistry and mechanism of pinacol-type rearrangements in the 1-phenyl-4-t-butylcyclohexane series
- Author
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Giancarlo Berti, B. Macchia, F. Macchia, Pl Barili, and L. Monti
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Steric effects ,chemistry.chemical_compound ,Carbonium ion ,Chemistry ,Stereochemistry ,Concerted reaction ,Pinacol ,Organic Chemistry ,T-butylcyclohexane ,chemistry.chemical_element ,Boron - Abstract
The two diastereoisomeric 1,2-epoxy-1-phenyl-4-t-butylcyclohexanes and the corresponding four diols are converted into mixtures of 2-phenyl-5-t-butylcyclohexanones and 1-phenyl-3-t-butylcyclopentanecarbaldehydes by boron trifluoride–ether complex. The steric course of these reactions is interpreted in terms of a mechanism involving open carbonium ion intermediates for the diols, whereas the rearrangement of the epoxides appears to be more concerted. The silver oxide-promoted rearrangements of the cis-chlorohydrins of the same series seem to be entirely concerted.
- Published
- 1970
215. Lista unica regionale per trapianto di rene
- Author
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BUSCAROLI, ANDREA, RIDOLFI L. KAPELJ S. MAZZETTI GAITO P ALVARO N. BONANNO M.C. FALASCHINI A. DE CILLIA C. CAMPIONE T. TASSONI A. DELVECCHIO C. PERSICO L. MONTI M. LABANTI M., Buscaroli Andrea, RIDOLFI L. KAPELJ S. MAZZETTI GAITO P ALVARO N. BONANNO M.C. FALASCHINI A CAMPIONE T. POMPONIO L. DELVECCHIO C. PERSICO L. MONTI M. LABANTI M., Buscaroli A., RIDOLFI L. MAZZETTI GAITO P. ALVARO N. BONANNO M.C. KAPELJ S. VENTUROLI N. PERSICO L. MONTI M. LABANTI M., RIDOLFI L. MAZZETTI GAITO P. ALVARO N. BONANNO M.C. KAPELJ S. VALBONETTI M. VENTUROLI N. PERSICO L. MONTI M., L.RIDOLFI, and A.Buscaroli
- Subjects
TRAPIANTO DI RENE ,EMILIA-ROMAGNA ,REGIONE EMILIA-ROMAGNA ,TRAPIANTO RENALE - Abstract
Relazione annuale relativa all'attività della lista unica regionale d'attesa per trapianto renale da donatore cadavere. Contiene i dati relativi alla tipologia dei pazienti in lista, la provenienza, i tempi d'attesa, gli entrati ed usciti nel corso dell'anno e i trapianti effettuati, nelle loro diverse tipologie, dai tre centri trapianto di rene regionali afferenti alla lista unica (Bologna, Modena e Parma).
- Published
- 2007
216. Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease
- Author
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Deborah Pietrobono, Nicola Petragnani, Vincenza Andrisano, Claudia Martini, Vincenzo Tumiatti, Nibal Betari, Serena Montanari, Simona Daniele, Lara Davani, Angela Nebbioso, Ettore Novellino, F. Frabetti, Barbara Monti, Pasquale Russomanno, Angela De Simone, Andrea Milelli, Federica Sarno, Lucia Altucci, Patrizia Ballerini, Raffaella Casadei, Valeria La Pietra, Mariarosaria Conte, Sabrina Petralla, De Simone, Angela, La Pietra, Valeria, Betari, Nibal, Petragnani, Nicola, Conte, Mariarosaria, Daniele, Simona, Pietrobono, Deborah, Martini, Claudia, Petralla, Sabrina, Casadei, Raffaella, Davani, Lara, Frabetti, Flavia, Russomanno, Pasquale, Novellino, Ettore, Montanari, Serena, Tumiatti, Vincenzo, Ballerini, Patrizia, Sarno, Federica, Nebbioso, Angela, Altucci, Lucia, Monti, Barbara, Andrisano, Vincenza, Milelli, Andrea, De Simone A, La Pietra V, Betari N, Petragnani N, Conte M, Daniele S, Pietrobono D, Martini C, Petralla S, Casadei R, Davani L, Frabetti F, Russomanno P, Novellino E, Montanari S, Tumiatti V, Ballerini P, Sarno F, Nebbioso A, Altucci L, Monti B, Andrisano V, Milelli A., De Simone, A., La Pietra, V., Betari, N., Petragnani, N., Conte, M., Daniele, S., Pietrobono, D., Martini, C., Petralla, S., Casadei, R., D'Avani, Paolo, Frabetti, F., Novellino, E., Montanari, S., Tumiatti, V., Ballerini, P., Sarno, F., Nebbioso, A., Altucci, L., Monti, B., Andrisano, ANGELA-MARIA, and Milelli, A.
- Subjects
dual binding agents ,Polypharmacology, epigenetics, dual binding agents, glycogen synthase kinase 3β, histone deacetylases, neuroprotection ,Polypharmacology ,Disease ,01 natural sciences ,Biochemistry ,Neuroprotection ,GSK-3 ,Drug Discovery ,Epigenetics ,epigenetics ,glycogen synthase kinase 3β ,histone deacetylases ,neuroprotection ,biology ,010405 organic chemistry ,Chemistry ,Drug Discovery3003 Pharmaceutical Science ,Organic Chemistry ,Neurogenesis ,0104 chemical sciences ,Cell biology ,010404 medicinal & biomolecular chemistry ,Histone ,Cell culture ,Acetylation ,dual binding agent ,histone deacetylase ,biology.protein ,epigenetic - Abstract
[Image: see text] Several evidence pointed out the role of epigenetics in Alzheimer’s disease (AD) revealing strictly relationships between epigenetic and “classical” AD targets. Based on the reported connection among histone deacetylases (HDACs) and glycogen synthase kinase 3β (GSK-3β), herein we present the discovery and the biochemical characterization of the first-in-class hit compound able to exert promising anti-AD effects by modulating the targeted proteins in the low micromolar range of concentration. Compound 11 induces an increase in histone acetylation and a reduction of tau phosphorylation. It is nontoxic and protective against H(2)O(2) and 6-OHDA stimuli in SH-SY5Y and in CGN cell lines, respectively. Moreover, it promotes neurogenesis and displays immunomodulatory effects. Compound 11 shows no lethality in a wt-zebrafish model (
- Published
- 2019
217. Carbazole-Terpyridine Donor-Acceptor Dyads with Rigid π-Conjugated Bridges
- Author
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Andrea Baschieri, Nicola Armaroli, Letizia Sambri, Eleonora Pavoni, Elisa Bandini, Elia Matteucci, Filippo Monti, and Matteucci, E., Baschieri, A., Sambri, L., Monti, F., Pavoni, E, Bandini, E., Armaroli, N.
- Subjects
Materials science ,donor-acceptor dyads ,Electron donor ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Phenylene ,carbazole ,Moiety ,π-conjugated systems ,chemistry.chemical_classification ,Anthracene ,010405 organic chemistry ,Carbazole ,fluorescence ,terpyridines ,Solvatochromism ,General Chemistry ,?-conjugated systems ,Electron acceptor ,Carbazole, terpyridine, π‐conjugated bridges, D‐π‐A systems ,0104 chemical sciences ,Crystallography ,chemistry ,Terpyridine - Abstract
A series of molecules in which 9H-carbazole (electron donor, D) and 2,2':6',2''-terpyridine (electron acceptor, A) are connected through rigid π-conjugated bridges (D-π-A systems) have been synthesized and their photophysical properties examined in detail, with the support of DFT calculations. The bridges are made of different sequences of ethynylene, phenylene, and anthracene groups. The synthetic strategies involve condensation of 2-acetylpyridine with the aromatic aldehyde moiety on different functionalized π-conjugated bridges and couplings with carbazole derivatives. The system incorporating anthracene in the bridge shows the typical absorption and emission fingerprints of this polycyclic hydrocarbon. The other systems have HOMOs and LUMOs centred, respectively, over the carbazole and the bridge and exhibit solvatochromic charge-transfer (CT) luminescence with high photoluminescence yield up to 70 %, except when an ethynylene unit is directly attached to the carbazole ring, due to a trans-bent non-emissive π-σ* excited state.
- Published
- 2019
218. Obstacle problem for Arithmetic Asian options
- Author
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Andrea Pascucci, Laura Monti, A. Pascucci, and L. Monti
- Subjects
35Q91 ,MAT/05 Analisi matematica ,Computational Finance (q-fin.CP) ,SECS-S/06 Metodi matematici dell'economia e delle scienze attuariali e finanziarie ,General Medicine ,35R35 ,35K70 ,35R03 ,Algebra ,FOS: Economics and business ,Mathematics - Analysis of PDEs ,Quantitative Finance - Computational Finance ,MAT/06 Probabilità e statistica matematica ,Obstacle problem ,Free boundary problem ,FOS: Mathematics ,Asian option ,Financial problem ,Representation (mathematics) ,Mathematics ,Arithmetic mean ,Analysis of PDEs (math.AP) - Abstract
We prove existence, regularity and a Feynman–Kac representation formula of the strong solution to the free boundary problem arising in the financial problem of the pricing of the American Asian option with arithmetic average. To cite this article: L. Monti, A. Pascucci, C. R. Acad. Sci. Paris, Ser. I 347 (2009).
- Published
- 2009
219. Recycling-Independent Core Design for the ENHS Fuel Self-Sustaining Reactor
- Author
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Monti, Lanfranco, Lee, Ki-Bog, Massimiliano Fratoni, Sumini, Marco, Greenspan, Ehud, L. Monti, Ki-Bog Lee, M. Fratoni, M. Sumini, and E. Greenspan
- Subjects
ACTINIDE BURNER ,MONTE CARLO ,GEN-IV ,CORE DESIGN ,NUCLEAR REACTORS - Abstract
The feasibility of indefinite recycling in the Encapsulated Nuclear Heat Source (ENHS) core without changing the pitch-to-diameter (P/D) ratio, while maintaining a nearly zero burnup reactivity swing, is investigated. The P/D ratio required to achieve a nearly burnup-independent keff over the life of the ENHS core was found sensitive to the initial composition of the transuranium (TRU) loaded and to the number of recycles this fuel underwent. The longer the cooling time is of the TRU from light water reactor (LWR) spent fuel, the larger the optimal P/D ratio becomes. Whereas the optimal P/D ratio of the reference ENHS core that is fueled with TRU from LWR spent fuel discharged at 50 GWd/t heavy metal (HM) and cooled for 10 yr is 1.36, it is 1.54 for the equilibrium core that features a substantially smaller concentration of 241Pu as well as of 242Pu, a larger concentration of 239Pu, and a substantially larger concentration of minor actinides. It was found that by increasing the cooling period of the above LWR TRU to ~32 yr, the optimal first core P/D ratio is that of the equilibrium core. The burnup reactivity swing of the subsequent cores fueled with successive recycling of the ENHS discharged HM is satisfactory. There is no need to adjust the core P/D ratio from recycle to recycle. The power level that can be removed by natural circulation from the P/D = 1.54 core is ~36% higher than that of the reference ENHS core. The physical phenomena affecting the observed trends are discussed, and the neutronic characteristics of the equilibrium cores identified are summarized.
- Published
- 2009
220. Multi-recycling in the ENHS and the equilibrium core
- Author
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Massimiliano Fratoni, Ki-Bog Lee, Marco Sumini, Lanfranco Monti, Federico Rocchi, Ehud Greenspan, L. Monti, E. Greenspan, M. Sumini, M. Fratoni, K. B. Lee, and F. Rocchi
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Work (thermodynamics) ,Materials science ,Nuclear engineering ,EQUILIBRIUM CORE ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Nuclear reactor ,Spent nuclear fuel ,Plutonium ,law.invention ,Core (optical fiber) ,FUEL RECYCLING ,Nuclear Energy and Engineering ,chemistry ,law ,ENCAPSULATED NUCLEAR HEAT SOURCE ,POWER DENSITY ,OPTIMAL CORE DESIGN ,Safety, Risk, Reliability and Quality ,Waste Management and Disposal ,Radioactive decay ,Burnup ,Power density - Abstract
This work investigates the effect of initial fuel composition, power density and number of recycles on the pitch-to-diameter (P/D) ratio and TRans-Uranium isotopes (TRU) loading required for attaining one of the most important design goals of the Encapsulated Nuclear Heat Source (ENHS) e nearly zero burnup reactivity swing over the w20 years of core life. It is found that the required P/D ratio is sensitive to, primarily, the initial concentration of the short-lived isotope 241Pu in the fuel loaded into the first core and to the core power density. The longer is the cooling time of the TRU from LWR spent fuel the smaller becomes the relative 241Pu concentration and the smaller becomes the fraction of 241Pu lost via radioactive decay and, hence, the smaller needs be the conversion ratio required for nearly zero burnup reactivity swing and the larger can be the P/D ratio. Likewise, the higher is the ENHS power density, the smaller becomes the fraction of 241Pu lost via radioactive decay and the larger becomes the P/D required for the first core. The optimal P/D ratio tends to increase with the number of times the fuel is recycled from one ENHS core to the next one. The optimal P/D ratio for the equilibrium composition core is in between 1.53 and 1.59. For a given discharge burnup it tends to somewhat increase with the equilibrium core power density. However, if structural materials will be developed to enable a 20 years core life at elevated power densities, the higher the power density the smaller is the required equilibrium P/D ratio.
- Published
- 2008
221. Lista unica regionale per il trapianto di rene
- Author
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BUSCAROLI, ANDREA, RIDOLFI L. MAZZETTI GAITO P. VENTUROLI N. SESTIGIANI E. BONANNO M.C. RIGANELLO I. PERSICO L. MONTI M., and Buscaroli A.
- Subjects
TRAPIANTO RENALE - Abstract
Resoconto annuale dell'attività relativa alla lista d'attesa unica regionale per trapianto renale da donatore cadavere
- Published
- 2004
222. RESPONSABILITA' VERSO LE GENERAZIONI FUTURE
- Author
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POMARICI, Ulderico, L. Chieffi, G. Cocco, F. Francioni, A. Grignani, S. Grassi,M.A. La Torre,R. Manfrellotti, M. Miola, L. Monti, B. Nascimbene, D. Neri, S. Nespor, A. Pecoraro Scanio, U. Pomarici, R. Prodomo, F. Rossi Dal Pozzo, LORENZO CHIEFFI, and Pomarici, Ulderico
- Subjects
generazioni future ,biotecnologie ,ambiente - Published
- 2003
223. Sexual dysfunction in multiple sderosis: a case-control study. 1. Frequency and comparison of groups
- Author
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Zorzon, M., Zivadinov, R., Bosco, A., Monti Bragadin, L., Moretti, Rita, Bonfigli, L., Morassi, P., Cazzato Clinical Neurology, L. G. Iona G., University of Trieste, Trieste, Italy, M., Zorzon, R., Zivadinov, A., Bosco, L., Monti Bragadin, Moretti, Rita, L., Bonfigli, P., Morassi, L. G. Iona G., Cazzato Clinical Neurology, University of, Trieste, and Trieste, Italy
- Subjects
medicine.medical_specialty ,Pediatrics ,050109 social psychology ,Human sexuality ,multiple sclerosis ,Social life ,Central nervous system disease ,03 medical and health sciences ,Epidemiology ,medicine ,0501 psychology and cognitive sciences ,In patient ,sexual disturbances ,030505 public health ,business.industry ,Multiple sclerosis ,05 social sciences ,Case-control study ,medicine.disease ,Surgery ,Sexual dysfunction ,Neurology ,multiple sclerosi ,Neurology (clinical) ,medicine.symptom ,0305 other medical science ,business - Abstract
Sexual dysfunction is a very important but often overlooked symptom of multiple sclerosis. To investigate the type and frequency of symptoms of sexual dysfunction in patient suffering from multiple sclerosis, we performed a case-control study comparing 108 unselected patient with definite multiple sclerosis, 97 patient with chronic disease and 1 10 healthy individuals with regard to sexual function, sphincteric function, physical disorders impeding sexual activity and the impact of sexual dysfunction on social life. Information has been collected from a face-to-face structured interview performed by a doctor of the same gender as the patient. The disability, the cognitive performances, the psychiatric conditions and the psychological profile of patien t a nd co ntrols have bee n assessed. Sexul a dysfu nction was prese nt in 73.1% of cases, in 39.2% of chronic disease co ntrols and in 12.7% of h e althy co ntrols (P < 0.000 1). Male cases reported symptoms of sexual dysfunction more freq ue ntly th an female cases (P
- Published
- 1999
224. Prognostic value of right ventricular involvement in hypertrophic cardiomyopathy: A systematic review and meta-analysis.
- Author
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Figliozzi S, Masci PG, Monti L, Stankowski K, Tondi L, Aivalioti E, Mavraganis G, Francone M, Condorelli G, Olivotto I, and Georgiopoulos G
- Subjects
- Humans, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Prognosis, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic mortality, Cardiomyopathy, Hypertrophic physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right epidemiology, Ventricular Dysfunction, Right etiology, Ventricular Dysfunction, Right physiopathology
- Abstract
Background: Right ventricular (RV) involvement has been reported in one out of three patients with hypertrophic cardiomyopathy (HCM), however its prognostic significance remains unknown. We aimed to assess the prognostic value of RV involvement in patients with HCM through a systematic review and meta-analysis., Methods: A literature search was performed on PubMed, ClinicalTrials.gov and Cochrane Library databases from inception through November 15, 2023. Original articles enrolling HCM patients >18 years old and evaluating the association of RV parameters routinely assessed in clinical practice through trans-thoracic echocardiography or cardiac magnetic resonance (i.e., RV hypertrophy, volumes, systolic function, and late gadolinium enhancement) and the risk of a pre-defined composite endpoint including i) all cause death; ii) cardiac death; iii) heart transplantation; iv) heart failure-related hospitalization; v) atrial fibrillation; vi) ventricular tachycardia; and vii) stroke were retrieved. We pooled the effect of RV imaging variables on the combined clinical endpoint in terms of hazard ratio (HR) with 95% confidence interval (CI)., Results: The meta-analysis included 12 articles and 4634 patients. The pooled analysis demonstrated that the presence of RV systolic dysfunction conveyed an increased risk of adverse outcomes (HR 2.46; 95% CI 1.80-3.35; P < 0.001), whereas other RV imaging parameters were not significantly associated with patients' prognosis, except for RV-fractional area change analyzed as a continuous variable (HR 0.96 per % increase; 95% CI 0.93-0.995; P = 0.025)., Conclusions: Our results pinpoint a prognostic role of RV dysfunction, independent of left ventricular involvement, in patients with HCM, and future longitudinal studies, including multi-parametric RV assessment, are encouraged to provide clinically-relevant data to refine risk stratification in patients with HCM., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier B.V.)
- Published
- 2024
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225. Prognostic value of stress CMR and SPECT-MPI in patients undergoing intermediate-to-high-risk non-cardiac surgery.
- Author
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Fazzari F, Lisi C, Catapano F, Cannata F, Brilli F, Figliozzi S, Bragato RM, Stefanini GG, Monti L, and Francone M
- Subjects
- Humans, Female, Male, Retrospective Studies, Aged, Middle Aged, Prognosis, Magnetic Resonance Imaging methods, Postoperative Complications diagnostic imaging, Risk Factors, Tomography, Emission-Computed, Single-Photon methods, Myocardial Perfusion Imaging methods, Exercise Test, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease surgery
- Abstract
Purpose: The objective of this study was to investigate the role of myocardial perfusion imaging (MPI) stress tests using stress cardiac magnetic resonance (sCMR) and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) in non-cardiac surgery (NCS) pre-operatory management., Materials and Methods: This monocentric retrospective study enrolled patients with coronary artery disease or a minimum of two cardiovascular risk factors undergoing intermediate-to-high-risk non-cardiac surgeries. The primary composite endpoint comprised cardiac death, cardiogenic shock, acute coronary syndromes (ACS), and cardiogenic pulmonary edema occurring within 30 days after surgery, while the secondary endpoint was ACS., Results: A total of 1590 patients were enrolled; among them, 669 underwent a MPI stress test strategy (sCMR: 287, SPECT-MPI: 382). The incidence of 30-day cardiac events was lower in the stress-tested group compared to the non-stress-tested group (1.2% vs. 3.4%; p 0.006). Adopting a stress test strategy showed a significant reduction in the risk of the composite endpoint (OR: 0.33, 95% CI: 0.15-0.76, p 0.009) and ACS (OR: 0.41, 95% CI: 0.17-0.98, p 0.046) at multivariable analysis, with similar cardiac events rate between stress CMR and SPECT (1.1% vs. 1.3%, p 0.756). Stress CMR showed a greater accuracy to predict coronary artery revascularizations (sCMR c-statistic: 0.95, ischemic cut-point: 5.5%; SPECT c-statistic: 0.85, ischemic cut-point: 7.5%)., Conclusion: Stress test strategy is related to a lower occurrence of cardiac events in high-risk patients scheduled for intermediate-to-high-risk non-cardiac surgeries. Both sCMR and SPECT-MPI comparably reduce the likelihood of cardiac complications, albeit sCMR offers greater accuracy in predicting coronary artery revascularization., (© 2024. The Author(s).)
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- 2024
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226. Fabry disease: a rare disorder calling for personalized medicine.
- Author
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Lerario S, Monti L, Ambrosetti I, Luglio A, Pietra A, Aiello V, Montanari F, Bellasi A, Zaza G, Galante A, Salera D, Capelli I, La Manna G, and Provenzano M
- Subjects
- Humans, alpha-Galactosidase therapeutic use, alpha-Galactosidase genetics, Rare Diseases therapy, Genetic Therapy, Fabry Disease therapy, Fabry Disease genetics, Fabry Disease diagnosis, Precision Medicine, Enzyme Replacement Therapy
- Abstract
Fabry Disease (FD) is a genetic disease caused by a deficiency in the activity of lysosomal galactosidase A (α-GalA), an enzyme responsible for the catabolism of globotriaosylceramide (Gb3). Since lysosomes are present throughout the body and play a crucial role in catabolism and recycling of cytosolic compounds, FD can affect multiple organs and result in various symptoms, including renal, cardiovascular, neurological, cutaneous, and ophthalmic manifestations. Due to the nonspecific symptoms and the rarity of FD, it is often diagnosed late in life. However, introducing targeted therapies such as enzyme replacement therapy (ERT) and chaperone therapy has significantly improved FD's natural history and prognosis by restoring α-GalA enzyme activity. Despite the advancements, there are limitations to the currently available therapies, which has prompted research into new potential treatments for FD, including alternative forms of enzyme replacement therapy, substrate reduction therapy, mRNA therapy, and genetic therapy. In this review, we analyze the epidemiology, pathophysiology, and treatment of FD, with particular emphasis on promising therapeutic opportunities that could shift the treatment of this rare disease from a standardized to a personalized approach soon., (© 2024. The Author(s).)
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- 2024
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- View/download PDF
227. Add-on rituximab for primary heart involvement associated with systemic sclerosis: A step forward in the tailored treatment of myocarditis?
- Author
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De Santis M, Tonutti A, Motta F, Rodolfi S, Monti L, Catapano F, Francone M, and Selmi C
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- 2024
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228. Familial DMRT1-related non-obstructive azoospermia: a case report.
- Author
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Severi G, Ambrosini E, Caramanna L, Monti L, Magini P, and Innella G
- Abstract
Purpose: To report an exceptional case of male-to-male transmission of genetically based non-obstructive azoospermia (NOA) and varicocele through a naturally obtained pregnancy., Subjects and Methods: A father and his son were both diagnosed with NOA after centrifugation and varicocele. The father has no other clinical concerns apart from infertility, detected after many attempts of having another child, but given his urological situation (bilateral varicocele and NOA) assisted reproductive techniques were discouraged. After genetic counseling, several genetic-chromosomal analyses were carried out in the son (karyotype, chromosome Y microdeletions, CFTR screening, NGS infertility panels, and finally array-CGH)., Results: After a series of inconclusive tests, array-CGH detected a deletion of 224-283 kb (del9p24.3) involving part of the KANK1 and DMRT1 genes, inherited from the father. Haploinsufficiency of DMRT1 was therefore considered the determining factor in the development of azoospermia in the family by a loss of function mechanism., Conclusion: The confirmation of father-to-son transmission of a deletion including DMRT1 represents an important point for clinicians dealing with male infertility, even when complete azoospermia is repetitively detected, and must be of hope for a relevant portion of men. Inclusion criteria for the access to assisted reproductive techniques may also be reconsidered and worthy of a greater number of clinical insights. Finally, since DMRT1 alterations have been associated with NOA and abnormal testicular development, but not specifically with varicocele, further studies are required to validate this issue, as varicocele may have played a crucial role in this case., (© 2024. The Author(s).)
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- 2024
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229. Obstetric Outcomes in Women on Lithium: A Systematic Review and Meta-Analysis.
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Callovini T, Montanari S, Bardi F, Barbonetti S, Rossi S, Caso R, Mandracchia G, Margoni S, Brugnami A, Paolini M, Manfredi G, Giudice LL, Segatori D, Zanzarri A, Onori L, Calderoni C, Benini E, Marano G, Massetti M, Fiaschè F, Di Segni F, Janiri D, Simonetti A, Moccia L, Grisoni F, Ruggiero S, Bartolucci G, Biscosi M, Ferrara OM, Bernardi E, Monacelli L, Giannico AM, De Berardis D, Battisti G, Ciliberto M, Brisi C, Lisci FM, D'Onofrio AM, Restaino A, Di Benedetto L, Anesini MB, Boggio G, Specogna E, Crupi A, De Chiara E, Caroppo E, Ieritano V, Monti L, Chieffo DPR, Rinaldi L, Camardese G, Cuomo I, Brugnoli R, Kotzalidis GD, Sani G, and Mazza M
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Background/Objectives : Lithium taken during pregnancy was linked in the past with increased risk for foetal/newborn malformations, but clinicians believe that it is worse for newborn children not to treat the mothers' underlying psychiatric illness. We set to review the available evidence of adverse foetal outcomes in women who received lithium treatment for some time during their pregnancy. Methods : We searched four databases and a register to seek papers reporting neonatal outcomes of women who took lithium during their pregnancy by using the appropriate terms. We adopted the PRISMA statement and used Delphi rounds among all the authors to assess eligibility and the Cochrane Risk-of-Bias tool to evaluate the RoB of the included studies. Results : We found 28 eligible studies, 10 of which met the criteria for inclusion in the meta-analysis. The studies regarded 1402 newborn babies and 2595 women exposed to lithium. Overall, the systematic review found slightly increased adverse pregnancy outcomes for women taking lithium for both the first trimester only and any time during pregnancy, while the meta-analysis found increased odds for cardiac or other malformations, preterm birth, and a large size for gestational age with lithium at any time during pregnancy. Conclusions : Women with BD planning a pregnancy should consider discontinuing lithium when euthymic; lithium use during the first trimester and at any time during pregnancy increases the odds for some adverse pregnancy outcomes. Once the pregnancy has started, there is no reason for discontinuing lithium; close foetal monitoring and regular blood lithium levels may obviate some disadvantages of lithium administration during pregnancy.
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- 2024
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230. Leveraging Deep Learning for Time-Series Extrinsic Regression in Predicting the Photometric Metallicity of Fundamental-Mode RR Lyrae Stars.
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Monti L, Muraveva T, Clementini G, and Garofalo A
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Astronomy is entering an unprecedented era of big-data science, driven by missions like the ESA's Gaia telescope, which aims to map the Milky Way in three dimensions. Gaia's vast dataset presents a monumental challenge for traditional analysis methods. The sheer scale of this data exceeds the capabilities of manual exploration, necessitating the utilization of advanced computational techniques. In response to this challenge, we developed a novel approach leveraging deep learning to estimate the metallicity of fundamental mode (ab-type) RR Lyrae stars from their light curves in the Gaia optical G-band. Our study explores applying deep-learning techniques, particularly advanced neural-network architectures, in predicting photometric metallicity from time-series data. Our deep-learning models demonstrated notable predictive performance, with a low mean absolute error (MAE) of 0.0565, the root mean square error (RMSE) of 0.0765, and a high R2 regression performance of 0.9401, measured by cross-validation. The weighted mean absolute error (wMAE) is 0.0563, while the weighted root mean square error (wRMSE) is 0.0763. These results showcase the effectiveness of our approach in accurately estimating metallicity values. Our work underscores the importance of deep learning in astronomical research, particularly with large datasets from missions like Gaia. By harnessing the power of deep-learning methods, we can provide precision in analyzing vast datasets, contributing to more precise and comprehensive insights into complex astronomical phenomena.
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- 2024
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231. Role of Cine-Magnetic Resonance Imaging in the Assessment of Mediastinal Masses with Uncertain/Equivocal Findings from Pre-Operative Computed Tomography Scanning.
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Cariboni U, Monti L, Voulaz E, Civilini E, Citterio E, Lisi C, and Marulli G
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Background: Malignant neoplasms originating from or involving the mediastinum represent a diagnostic and therapeutic challenge when they are in contact with nearby cardiovascular structures. We aimed to test the diagnostic accuracy of cine-magnetic resonance imaging (cine-MRI) in detecting the infiltration of cardiovascular structures in cases with uncertain or equivocal findings from contrast-enhanced Computed Tomography (CT) scanning., Methods: Fifty patients affected by tumors with a suspected invasion of mediastinal cardiovascular structures at the pre-operative chest CT scan stage underwent cine-MRI before surgery at our Institution. Intraoperative findings and the histological post-surgical report were used as a reference standard to define infiltration. Inter- and intra-observer agreement for CT scans and cine-MRI were also computed over a homogenous sample of 14 patients., Results: Cine-MRI had a higher negative predictive value (93% vs. 54%, p < 0.001) than CT scans, higher sensitivity (91% vs. 16%, p < 0.001), as well as greater accuracy (66% vs. 50%, p < 0.001) in detecting cardiovascular invasion. Cine-MRI also showed better inter- and intra-observer agreement for infiltration detection., Conclusions: Cine-MRI outperforms conventional contrast-enhanced chest CT scans in the preoperative assessment of cardiovascular infiltration by mediastinal or pulmonary tumors, making it a useful imaging modality in the preoperative staging and evaluation of patients with equivocal findings at the chest CT scan stage.
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- 2024
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232. Intramural Hematoma and Acute Pulmonary Embolism Following Pacemaker Implantation: A Case Report.
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Del Monaco G, Taormina A, Giaj Levra A, Monti L, and Frontera A
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Bleeding complications after pacemaker implantation pose risks, including infection and prolonged hospital stay. A case involving aortic intramural hematoma (IMH) arising from subclavian vein access during implantation and concomitant acute pulmonary embolism (PE) is presented. In the present case, IMH probably resulted from subclavian artery vasa vasorum trauma during vein puncture and guidewire advancement, leading to IMH and hemothorax. PE possibly stemmed from a prothrombotic state caused by the intervention and the IMH. Conservative management with serial CT scans was chosen due to hemodynamic stability and high surgical risk. IMH and PE resolution was confirmed at follow-up., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Del Monaco et al.)
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- 2024
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233. Mitral annulus disjunction in consecutive patients undergoing cardiovascular magnetic resonance: Where is the boundary between normality and disease?
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Figliozzi S, Stankowski K, Tondi L, Catapano F, Gitto M, Lisi C, Bombace S, Olivieri M, Cannata F, Fazzari F, Bragato RM, Georgiopoulos G, Masci PG, Monti L, Condorelli G, and Francone M
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Background: The presence of mitral annulus disjunction (MAD) has been considered a high-risk feature for sudden cardiac death based on selected study populations. We aimed to assess the prevalence of MAD in consecutive patients undergoing clinically indicated cardiovascular magnetic resonance (CMR), its association with ventricular arrhythmias, mitral valve prolapse (MVP), and other CMR features., Methods: This single-center retrospective study included consecutive patients referred to CMR at our institution between June 2021 and November 2021. MAD was defined as a ≥1 mm displacement between the left atrial wall-mitral valve leaflet junction and the left ventricular wall during end-systole. MAD extent was defined as the maximum longitudinal displacement. Associates of MAD were evaluated at univariable and multivariable regression analysis. The study endpoint, a composite of (aborted) sudden cardiac death, unexplained syncope, and sustained ventricular tachycardia, was evaluated at a 12-month follow-up., Results: Four hundred and forty-one patients 55 ± 18 years, 267/441 (61%) males) were included, and 29/441 (7%) had MVP. The prevalence of MAD ≥1 mm, 4 mm, and 6 mm was 214/441 (49%), 63/441 (14%), and 15/441 (3%), respectively. Patients with MVP showed a higher prevalence of MAD greater than 1 mm (26/29 (90%) vs 118/412 (46%)); p < 0.001), 4 mm (14/29 (48%) vs 49/412 (12%)); p < 0.001), and 6 mm (3/29 (10%) vs 12/412 (3%)); p = 0.03), and a greater MAD extent (4.2 mm, 3.0-5.7 mm vs 2.8 mm, 1.9-4.0 mm; p < 0.001) compared to patients without MVP. MVP was the only morpho-functional abnormality associated with MAD at multivariable analysis (p < 0.001). A high burden of ventricular ectopic beats at baseline Holter-electrocardiogram was associated with MAD ≥4 mm and MAD extent (p < 0.05). The presence of MAD ≥1 mm (0.9% vs 1.8%; p = 0.46), MAD ≥4 mm (1.6% vs 1.3%; p = 0.87), or MVP (3.5% vs 1.2%; p = 0.32) were not associated with the study endpoint, whereas patients with MAD ≥6 mm showed a trend toward a higher likelihood of the study endpoint (6.7% vs 1.2%; p = 0.07)., Conclusion: MAD of limited severity was common in consecutive patients undergoing CMR. Patients with MVP showed higher prevalence and greater extent of MAD. Extended MAD was rarer and showed association with ventricular arrhythmias at baseline. The mid-term prognosis of MAD seems benign; however, prospective studies are warranted to search for potential "malignant MAD extents" to improve patients' risk stratification., Competing Interests: Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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234. CT imaging post-TAVI: Murphy's first law in action-preparing to recognize the unexpected.
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Lisi C, Catapano F, Brilli F, Scialò V, Corghi E, Figliozzi S, Cozzi OF, Monti L, Stefanini GG, and Francone M
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Transfemoral aortic valve implantation (TAVI) has been long considered the standard of therapy for high-risk patients with severe aortic-stenosis and is now effectively employed in place of surgical aortic valve replacement also in intermediate-risk patients. The potential lasting consequences of minor complications, which might have limited impact on elderly patients, could be more noteworthy in the longer term when occurring in younger individuals. That's why a greater focus on early diagnosis, correct management, and prevention of post-procedural complications is key to achieve satisfactory results. ECG-triggered multidetector computed tomography angiography (CTA) is the mainstay imaging modality for pre-procedural planning of TAVI and is also used for post-interventional early detection of both acute and long-term complications. CTA allows detailed morphological analysis of the valve and its movement throughout the entire cardiac cycle. Moreover, stent position, coronary artery branches, and integrity of the aortic root can be precisely evaluated. Imaging reliability implies the correct technical setting of the computed tomography scan, knowledge of valve type, normal post-interventional findings, and awareness of classic and life-threatening complications after a TAVI procedure. This educational review discusses the main post-procedural complications of TAVI with a specific imaging focus, trying to clearly describe the technical aspects of CTA Imaging in post-TAVI and its clinical applications and challenges, with a final focus on future perspectives and emerging technologies. CRITICAL RELEVANCE STATEMENT: This review undertakes an analysis of the role computed tomography angiography (CTA) plays in the assessment of post-TAVI complications. Highlighting the educational issues related to the topic, empowers radiologists to refine their clinical approach, contributing to enhanced patient care. KEY POINTS: Prompt recognition of TAVI complications, ranging from value issues to death, is crucial. Adherence to recommended scanning protocols, and the optimization of tailored protocols, is essential. CTA is central in the diagnosis of TAVI complications and functions as a gatekeeper to treatment., (© 2024. The Author(s).)
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- 2024
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235. This pain drives me crazy: Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome.
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Mazza M, Margoni S, Mandracchia G, Donofrio G, Fischetti A, Kotzalidis GD, Marano G, Simonetti A, Janiri D, Moccia L, Marcelli I, Sfratta G, De Berardis D, Ferrara O, Bernardi E, Restaino A, Lisci FM, D'Onofrio AM, Brisi C, Grisoni F, Calderoni C, Ciliberto M, Brugnami A, Rossi S, Spera MC, De Masi V, Marzo EM, Abate F, Boggio G, Anesini MB, Falsini C, Quintano A, Torresi A, Milintenda M, Bartolucci G, Biscosi M, Ruggiero S, Lo Giudice L, Mastroeni G, Benini E, Di Benedetto L, Caso R, Pesaresi F, Traccis F, Onori L, Chisari L, Monacelli L, Acanfora M, Gaetani E, Marturano M, Barbonetti S, Specogna E, Bardi F, De Chiara E, Stella G, Zanzarri A, Tavoletta F, Crupi A, Battisti G, Monti L, Camardese G, Chieffo D, Gasbarrini A, Scambia G, and Sani G
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Background: Interstitial cystitis/bladder pain syndrome (IC/BPS) is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic, abdominal, and/or pelvic pain. Although the term cystitis suggests an inflammatory or infectious origin, no definite cause has been identified. It occurs in both sexes, but women are twice as much affected., Aim: To systematically review evidence of psychiatric/psychological changes in persons with IC/BPS., Methods: Hypothesizing that particular psychological characteristics could underpin IC/BPS, we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy: ("interstitial cystitis" OR "bladder pain syndrome") AND ("mood disorder" OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cycl
asterisk OR dysthymiasterisk OR dysphoriasterisk )., Results: On September 27, 2023, the PubMed search produced 223 articles, CINAHL 62, and the combined PsycLIT/ PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search 36. Search on ClinicalTrials.gov produced 14 studies, of which none had available data. Eligible were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS, i.e. 63 articles spanning from 2000 to October 2023. These studies identified depression and anxiety problems in the IC/BPS population, along with sleep problems and the tendency to catastrophizing., Conclusion: Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/BPS. Such concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain., Competing Interests: Conflict-of-interest statement: All authors declare having no conflicts of interest., (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)- Published
- 2024
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236. Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry.
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Li W, van der Doef HPJ, Wildhaber BE, Marra P, Bravi M, Pinelli D, Minetto J, Dip M, Sierre S, de Santibañes M, Ardiles V, Uno JW, Hardikar W, Bates S, Goh L, Aldrian D, Seisenbacher J, Vogel GF, Neto JS, Antunes da Fonseca E, Magalhães Costa C, Ferreira CT, Nader LS, Farina MA, Dajani KZ, Parente A, Bigam DL, Liang TB, Bai X, Zhang W, Gonsorčíková L, Froněk J, Bohuš Š, Franchi-Abella S, Gonzales E, Guérin F, Junge N, Baumann U, Richter N, Hartleif S, Sturm E, Rajakannu M, Palaniappan K, Rela M, Pawaria A, Rajakrishnan H, Surendran S, Kumar M, Agarwal S, Gupta S, Asthana S, Bandewar V, Raichurkar K, Spada M, Monti L, Alterio T, Yanagi Y, Uchida H, Komine R, Evans H, Carr-Boyd P, Duncan D, Stefanowicz M, Latka-Grot J, Kolesnik A, Broering DC, Raptis DA, Ann H Marquez K, Mali V, Aw M, Beretta M, Van der Schyff F, Quintero-Bernabeu J, Mercadal-Hally M, Larrarte K M, Andres AM, Hernandez-Oliveros F, Frauca E, Casswall T, Jorns C, Delle M, Gupte G, Sharif K, McGuirk S, Superina R, Caicedo JC, Jaramillo C, Bitterfeld L, Kastenberg Z, Shah AA, Domenick B, Acord MR, Mazariegos GV, Soltys K, DiNorcia J, Antala S, Florman SS, Buchholz BM, Herden U, Fischer L, Dierckx RAJO, Hartog H, and Bokkers RPH
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- Humans, Retrospective Studies, Child, Incidence, Adolescent, Child, Preschool, Female, Male, Constriction, Pathologic etiology, Infant, Multicenter Studies as Topic, Hepatic Artery, Liver Transplantation adverse effects, Registries, Postoperative Complications epidemiology, Postoperative Complications etiology, Thrombosis etiology, Thrombosis epidemiology
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Introduction: Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications., Methods and Analysis: The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC., Ethics and Dissemination: All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals., Trial Registration Number: The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier: NCT05818644., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2024
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237. Arrhythmic Mitral Valve Prolapse Phenotype: An Unsupervised Machine Learning Analysis Using a Multicenter Cardiac MRI Registry.
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Akyea RK, Figliozzi S, Lopes PM, Bauer KB, Moura-Ferreira S, Tondi L, Mushtaq S, Censi S, Pavon AG, Bassi I, Galian-Gay L, Teske AJ, Biondi F, Filomena D, Stylianidis V, Torlasco C, Muraru D, Monney P, Quattrocchi G, Maestrini V, Agati L, Monti L, Pedrotti P, Vandenberk B, Squeri A, Lombardi M, Ferreira AM, Schwitter J, Aquaro GD, Pontone G, Chiribiri A, Rodríguez Palomares JF, Yilmaz A, Andreini D, Florian AR, Francone M, Leiner T, Abecasis J, Badano LP, Bogaert J, Georgiopoulos G, and Masci PG
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- Humans, Female, Male, Middle Aged, Retrospective Studies, Registries, Magnetic Resonance Imaging, Cine methods, Arrhythmias, Cardiac diagnostic imaging, Arrhythmias, Cardiac physiopathology, Adult, Magnetic Resonance Imaging, Mitral Valve Prolapse diagnostic imaging, Unsupervised Machine Learning, Phenotype
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Purpose To use unsupervised machine learning to identify phenotypic clusters with increased risk of arrhythmic mitral valve prolapse (MVP). Materials and Methods This retrospective study included patients with MVP without hemodynamically significant mitral regurgitation or left ventricular (LV) dysfunction undergoing late gadolinium enhancement (LGE) cardiac MRI between October 2007 and June 2020 in 15 European tertiary centers. The study end point was a composite of sustained ventricular tachycardia, (aborted) sudden cardiac death, or unexplained syncope. Unsupervised data-driven hierarchical k -mean algorithm was utilized to identify phenotypic clusters. The association between clusters and the study end point was assessed by Cox proportional hazards model. Results A total of 474 patients (mean age, 47 years ± 16 [SD]; 244 female, 230 male) with two phenotypic clusters were identified. Patients in cluster 2 (199 of 474, 42%) had more severe mitral valve degeneration (ie, bileaflet MVP and leaflet displacement), left and right heart chamber remodeling, and myocardial fibrosis as assessed with LGE cardiac MRI than those in cluster 1. Demographic and clinical features (ie, symptoms, arrhythmias at Holter monitoring) had negligible contribution in differentiating the two clusters. Compared with cluster 1, the risk of developing the study end point over a median follow-up of 39 months was significantly higher in cluster 2 patients (hazard ratio: 3.79 [95% CI: 1.19, 12.12], P = .02) after adjustment for LGE extent. Conclusion Among patients with MVP without significant mitral regurgitation or LV dysfunction, unsupervised machine learning enabled the identification of two phenotypic clusters with distinct arrhythmic outcomes based primarily on cardiac MRI features. These results encourage the use of in-depth imaging-based phenotyping for implementing arrhythmic risk prediction in MVP. Keywords: MR Imaging, Cardiac, Cardiac MRI, Mitral Valve Prolapse, Cluster Analysis, Ventricular Arrhythmia, Sudden Cardiac Death, Unsupervised Machine Learning Supplemental material is available for this article. © RSNA, 2024.
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- 2024
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238. Multiparametric Mapping via Cardiovascular Magnetic Resonance in the Risk Stratification of Ventricular Arrhythmias and Sudden Cardiac Death.
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Lo Monaco M, Stankowski K, Figliozzi S, Nicoli F, Scialò V, Gad A, Lisi C, Marchini F, Dellino CM, Mollace R, Catapano F, Stefanini GG, Monti L, Condorelli G, Bertella E, and Francone M
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- Humans, Risk Assessment methods, Magnetic Resonance Imaging methods, Defibrillators, Implantable, Tachycardia, Ventricular complications, Death, Sudden, Cardiac prevention & control, Death, Sudden, Cardiac etiology, Arrhythmias, Cardiac complications
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Risk stratification for malignant ventricular arrhythmias and sudden cardiac death is a daunting task for physicians in daily practice. Multiparametric mapping sequences obtained via cardiovascular magnetic resonance imaging can improve the risk stratification for malignant ventricular arrhythmias by unveiling the presence of pathophysiological pro-arrhythmogenic processes. However, their employment in clinical practice is still restricted. The present review explores the current evidence supporting the association between mapping abnormalities and the risk of ventricular arrhythmias in several cardiovascular diseases. The key message is that further clinical studies are needed to test the additional value of mapping techniques beyond conventional cardiovascular magnetic resonance imaging for selecting patients eligible for an implantable cardioverter defibrillator.
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- 2024
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239. Biliary atresia in preterm infants: a single center experience and review of literature.
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Beati F, Mosca A, Pietrobattista A, Liccardo D, Ronci S, Monti L, Francalanci P, Spada M, Maggiore G, Bagolan P, and Fusaro F
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Introduction: The diagnosis of biliary atresia (BA) remains challenging, and there is still uncertainty regarding the optimal time to perform a Kasai portoenterostomy (KPE). Little is known about the difficulties in the diagnosis and outcomes of BA in preterm infants (PBA). This study, which represents the first Italian report of preterm infants with BA, aims to describe a single-center experience of BA in preterm newborns., Methods: We retrospectively reviewed all infants consecutively diagnosed with BA who underwent a Kasai procedure at the Bambino Gesù Children's Hospital between January 1998 and December 2021. Prematurity was defined as a gestational age (GA) of <37 weeks. Demographic, laboratory, and histology data were recorded, and the main outcomes considered were clearance of jaundice (COJ), native liver survival, and mortality., Results: A total of 21 PBA were compared with 117 term BA controls (TBA). The median GA of PBA was 35.1 (32-36.1) weeks, with a mean birth weight of 2,100 (1,897-2,800) g. Age at first presentation was significantly lower in PBA patients: 46 (22-68) vs. 61 (44-72) days; p = 0.02. The median age at KPE was similar between the two groups: 70 days (33 corrected) for PBA vs. 67 in TBA; p = 0.8. At the time of surgery, median serum bilirubin was lower in the PBA group (7.7 vs. 8.6 mg/dl, p = 0.04). Similarly, the median APRi at the time of KPE was lower but not significant in the PBA group: 1.09 vs. 1.16; p = 0.8. No differences were found in terms of COJ between the PBA and TBA groups: n = 9 (43%) vs. 34 (35%); p = 0.2. Overall native liver survival was similar between the two groups: 8.6 (4.8-12.2) for the PBA group vs. 7.6 (5.6-9.5) years for the TBA group with no significant differences; p = 0.45. Post-KPE native liver survival was similar between the two groups: 38% vs. 52% at 5 years for the TBA and PBA groups, respectively; p = 0.54., Conclusion: The PBA and TBA groups appear to have similar outcomes in terms of COJ, overall native liver survival, and 5-year liver survival. Considering the corrected GA, early KPE is related to lower cholestatic damage. Further multicenter studies are required., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Beati, Mosca, Pietrobattista, Liccardo, Ronci, Monti, Francalanci, Spada, Maggiore, Bagolan and Fusaro.)
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- 2024
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240. Effect of fasedienol (PH94B) pherine nasal spray and steroidal hormones on electrogram responses and autonomic nervous system activity in healthy adult volunteers.
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Monti L, Hanover R, Salmán E, Baker RA, Lappalainen J, and Smith M
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- Adult, Female, Humans, Male, Estradiol, Healthy Volunteers, Propylene Glycols, Autonomic Nervous System physiology, Nasal Sprays
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Objective: Fasedienol (PH94B) is a pherine compound formulated as a nasal spray that is hypothesized to regulate olfactory-amygdala circuits of fear and anxiety. Fasedienol's effect on the local electrogram of nasal chemosensory neurons (EGNR) and autonomic nervous system (ANS) responses versus steroidal hormones and controls in healthy adults is reported., Methods: Eight males and 8 females randomly received aerosolized control (propylene glycol) and study drugs (fasedienol, 17β-estradiol, progesterone, cortisol, and testosterone, 0.4 μg each in propylene glycol) onto the nasal septum mucosal lining at 30-min intervals over 2 sessions. EGNR was continuously monitored; autonomic parameters were recorded before and after administration., Results: Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p < 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones., Conclusions: Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions., (© 2024 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd.)
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- 2024
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241. New pharmacotherapies to tackle the unmet needs in bipolar disorder: a focus on acute suicidality.
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Kotzalidis GD, Fiaschè F, Alcibiade A, Monti L, Di Segni F, Mazza M, and Sani G
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- Humans, Ketamine therapeutic use, Ketamine administration & dosage, Antidepressive Agents therapeutic use, Antidepressive Agents administration & dosage, Antipsychotic Agents therapeutic use, Antipsychotic Agents administration & dosage, Antimanic Agents therapeutic use, Antimanic Agents administration & dosage, Suicidal Ideation, Bipolar Disorder drug therapy, Suicide Prevention, Suicide psychology
- Abstract
Introduction: Suicidal behavior is relatively frequent in patients with bipolar disorder (BD) and constitutes their most frequent cause of death. Suicide rates remain high in patients with BD despite adherence to guidelines recommending lithium as first line, and/or antidepressants, antipsychotics, psychotherapy, psychosocial interventions, and electroconvulsive therapy. Hence the need to identify more effective and rapid anti-suicide interventions., Areas Covered: To tackle the unmet needs of pharmacotherapy, we investigated the PubMed database on 24-25 January 2024 using strategies like ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (lithium[ti] OR clozapine[ti]), which obtained 3 results, and ('acute suicid*'[ti] OR 'suicide crisis syndrome' OR 'acute suicidal affective disturbance') AND (ketamine[ti] OR esketamine[ti] OR NMDA[ti] OR glutamat*[ti]), which yielded 14 results. We explored glutamatergic abnormalities in BD and suicide and found alterations in both. The noncompetitive NMDS antagonist ketamine and its S-enantiomer esketamine reportedly decrease acute suicidality., Expert Opinion: Intranasal esketamine or subcutaneous ketamine, single-bolus or intravenous, and possibly other glutamate receptor modulators may improve suicidal behavior in patients with unipolar and bipolar depression. This may be achieved through prompt remodulation of glutamate activity. The correct use of glutamatergic modulators could reduce acute suicidality and mortality in patients with BD.
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- 2024
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242. Deep Learning Image Reconstruction Algorithm for CCTA: Image Quality Assessment and Clinical Application.
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Catapano F, Lisi C, Savini G, Olivieri M, Figliozzi S, Caracciolo A, Monti L, and Francone M
- Subjects
- Humans, Artificial Intelligence, Prospective Studies, Reproducibility of Results, Radiographic Image Interpretation, Computer-Assisted methods, Radiation Dosage, Algorithms, Image Processing, Computer-Assisted, Computed Tomography Angiography, Deep Learning
- Abstract
Objective: The increasing number of coronary computed tomography angiography (CCTA) requests raised concerns about dose exposure. New dose reduction strategies based on artificial intelligence have been proposed to overcome limitations of iterative reconstruction (IR) algorithms. Our prospective study sought to explore the added value of deep-learning image reconstruction (DLIR) in comparison with a hybrid IR algorithm (adaptive statistical iterative reconstruction-veo [ASiR-V]) in CCTA, even in clinical challenging scenarios, as obesity, heavily calcified vessels and coronary stents., Methods: We prospectively included 103 consecutive patients who underwent CCTA. Data sets were reconstructed with ASiR-V and DLIR. For each reconstruction signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) was calculated, and qualitative assessment was made with a four-point Likert scale by two independent and blinded radiologists with different expertise., Results: Both SNR and CNR were significantly higher in DLIR (SNR-DLIR median value [interquartile range] of 13.89 [11.06-16.35] and SNR-ASiR-V 25.42 [22.46-32.22], P < 0.001; CNR-DLIR 16.84 [9.83-27.08] vs CNR-ASiR-V 10.09 [5.69-13.5], P < 0.001).Median qualitative score was 4 for DLIR images versus 3 for ASiR-V ( P < 0.001), with a good interreader reliability [intraclass correlation coefficient(2,1)e intraclass correlation coefficient(3,1) 0.60 for DLIR and 0.62 and 0.73 for ASiR-V].In the obese and in the "calcifications and stents" groups, DLIR showed significantly higher values of SNR (24.23 vs 11.11, P < 0.001 and 24.55 vs 14.09, P < 0.001, respectively) and CNR (16.08 vs 8.04, P = 0.008 and 17.31 vs 10.14, P = 0.003) and image quality., Conclusions: Deep-learning image reconstruction in CCTA allows better SNR, CNR, and qualitative assessment than ASiR-V, with an added value in the most challenging clinical scenarios., Competing Interests: The authors declare that they have no conflict of interests., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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243. Transseptal Balloon-Assisted Translocation of the Mitral Anterior Leaflet (BATMAN) in Mitral Valve-in-Ring Implantation.
- Author
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Oliva A, Mangieri A, Cozzi O, Bragato R, Sticchi A, Bertoldi L, De Marco F, Monti L, Tosi P, Vitrella G, Torracca L, Reimers B, Colombo A, and Regazzoli D
- Subjects
- Humans, Mitral Valve diagnostic imaging, Mitral Valve surgery, Treatment Outcome, Cardiac Catheterization, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency surgery, Heart Valve Prosthesis Implantation adverse effects, Ventricular Outflow Obstruction surgery, Heart Valve Prosthesis
- Abstract
Competing Interests: Funding Support and Author Disclosures Dr Mangieri serves as a proctor for P&F Products&Features GmbH and Kardia; has received an institutional grant from Boston Scientific; and has received speaker honoraria from Boston Scientific, Concept Medical, Edwards Lifesciences, and Abbott. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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- 2024
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244. Psychological factors and barriers to donating and receiving milk from human milk banks: A review.
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Monti L, Massa S, Mallardi M, Arcangeli V, Serrao F, Costa S, Vento G, Mazza M, Simonetti A, Janiri D, Kotzalidis GD, Lanzone A, Mercuri EM, Sani G, and Chieffo DPR
- Subjects
- Infant, Child, Humans, Female, Health Knowledge, Attitudes, Practice, Breast Feeding, Mothers, Milk, Human, Milk Banks
- Abstract
Human milk banks (HMBs), established in the early 20th century, aimed to provide safe breast milk for infants with challenges obtaining it. The spread of infections since the 1980s resulted in strict regulations and screening in HMBs, to ensure the safety of donated milk. Several social and personal factors discourage mothers from practicing breastfeeding, making donated milk a viable alternative because of its protective and immunity-enhancing properties. However, psychological barriers can affect the decision to donate or receive donated milk. To identify psychological factors related to donating and receiving human milk from HMBs, we searched PubMed to identify studies reporting psychological factors in donating and receiving milk and excluding studies not reporting psychological factors. The search identified 28 articles meeting the inclusion criteria. Eligible studies from various countries spanned from 1995 to 2023 and focused on psychological factors influencing milk donation and receiving. Most studies were descriptive-qualitative. Factors facilitating or hindering milk donation and reception included perceptions, psychological aspects, and previous experiences. Positive factors for donors included the desire to help other mothers, support from health care professionals, and personal well-being. Negative factors included breast milk exclusivity and discomfort caused by health checks. For recipients, awareness of donated milk benefits was a positive factor, whereas fear regarding safety was negative. The altruistic motivation to help other mothers drove many women to donate. Proper awareness and support from health care professionals and families can help women understand the value of milk donation and support their personal and identity reintegration, especially in cases of the loss of a child., Competing Interests: Declaration of Competing Interest All authors declare no competing interests., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2024
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245. Histopathological Spectrum and Molecular Characterization of Liver Tumors in the Setting of Fontan-Associated Liver Disease.
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Francalanci P, Giovannoni I, Tancredi C, Gagliardi MG, Palmieri R, Brancaccio G, Spada M, Maggiore G, Pietrobattista A, Monti L, Castellano A, Giustiniani MC, Onetti Muda A, and Alaggio R
- Abstract
Purpose: Univentricular heart is corrected with the Fontan procedure (FP). In the long term, so-called Fontan-associated liver diseases (FALDs) can develop. The aim of this study is to analyze the molecular profile of FALDs., Methods: FALDs between January 1990 and December 2022 were reviewed for histology and immunohistochemistry, laboratory data, and images. Targeted next generation sequencing (NGS), performed on the DNA and RNA of both neoplastic and non-lesional liver tissue, was applied., Results: A total of 31/208 nodules > 1 cm in diameter were identified on imaging, but a liver biopsy was available for five patient demonstrating the following: one hepatocellular adenoma (HA), two hepatocellular carcinomas (HCCs), one fibrolamellar carcinoma (FLC), and one intrahepatic cholangiocarcinoma (ICC). Molecular analysis showed a copy number alteration involving FGFR3 in three cases (two HCCs and one ICC) as well as one HCC with a hotspot mutation on the CTNNB1 and NRAS genes. Tumor mutational burden ranged from low to intermediate. A variant of uncertain significance in GNAS was present in two HCCs and in one ICC. The same molecular profile was observed in a non-lesional liver. A DNAJB1-PRKACA fusion was detected only in one FLC., Conclusions: Neoplastic FALDs show some unusual molecular profiles compared with non-Fontan ones. The presence of the same alterations in non-lesional cardiac cirrhosis could contribute to the development of FALD.
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- 2024
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246. CMR Mapping: The 4th-Era Revolution in Cardiac Imaging.
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Carrabba N, Amico MA, Guaricci AI, Carella MC, Maestrini V, Monosilio S, Pedrotti P, Ricci F, Monti L, Figliozzi S, Torlasco C, Barison A, Baggiano A, Scatteia A, Pontone G, and Dellegrottaglie S
- Abstract
Cardiac magnetic resonance (CMR) imaging has witnessed substantial progress with the advent of parametric mapping techniques, most notably T1 and T2 mapping. These advanced techniques provide valuable insights into a wide range of cardiac conditions, including ischemic heart disease, cardiomyopathies, inflammatory cardiomyopathies, heart valve disease, and athlete's heart. Mapping could be the first sign of myocardial injury and oftentimes precedes symptoms, changes in ejection fraction, and irreversible myocardial remodeling. The ability of parametric mapping to offer a quantitative assessment of myocardial tissue properties addresses the limitations of conventional CMR methods, which often rely on qualitative or semiquantitative data. However, challenges persist, especially in terms of standardization and reference value establishment, hindering the wider clinical adoption of parametric mapping. Future developments should prioritize the standardization of techniques to enhance their clinical applicability, ultimately optimizing patient care pathways and outcomes. In this review, we endeavor to provide insights into the potential contributions of CMR mapping techniques in enhancing the diagnostic processes across a range of cardiac conditions.
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- 2024
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247. Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review.
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Sani G, Callovini T, Ferrara OM, Segatori D, Margoni S, Simonetti A, Lisci FM, Marano G, Fischetti A, Kotzalidis GD, Di Segni F, Fiaschè F, Janiri D, Moccia L, Manfredi G, Alcibiade A, Brisi C, Grisoni F, Stella G, Bernardi E, Brugnami A, Ciliberto M, Spera MC, Caso R, Rossi S, Boggio G, Mastroeni G, Abate F, Conte E, Quintano A, De Chiara L, Monti L, Camardese G, Rinaldi L, Koukopoulos AE, Chieffo DPR, Angeletti G, and Mazza M
- Subjects
- Humans, Pregnancy, Female, Pregnancy Complications drug therapy, Pregnancy Outcome, Prenatal Exposure Delayed Effects chemically induced, Prenatal Exposure Delayed Effects epidemiology, Infant, Newborn, Antipsychotic Agents adverse effects, Abnormalities, Drug-Induced epidemiology
- Abstract
There is much debate about continuing antipsychotic medication in patients who need it when they become pregnant because benefits must be weighed against potential teratogenic and malformation effects related to antipsychotics themselves. To address this, we conducted a systematic review on the PubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy: (toxicity OR teratogenicity OR malformation* OR "birth defect*" OR "congenital abnormality" OR "congenital abnormalities" OR "brain changes" OR "behavioral abnormalities" OR "behavioral abnormalities") AND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR perinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The oldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics, especially the second-generation antipsychotics, were devoid of teratogenic potential, while few studies were inconclusive and recommended replication. Most authoritative articles were from the Boston area, where large databases were implemented to study the malformation potential of psychiatric drugs. Other reliable databases are from Northern European registers. Overall conclusions are that antipsychotics are no more related to malformations than the disorders themselves; most studies recommend that there are no reasons to discontinue antipsychotic medications in pregnancy.
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- 2024
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248. Cardiac Masses and Pseudomasses: An Overview about Diagnostic Imaging and Clinical Background.
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Tagliati C, Fogante M, Palmisano A, Catapano F, Lisi C, Monti L, Lanni G, Cerimele F, Bernardini A, Procaccini L, Argalia G, Esposto Pirani P, Marcucci M, Rebonato A, Cerimele C, Luciano A, Cesarotto M, Belgrano M, Pagnan L, Sarno A, Cova MA, Ventura F, Regnicolo L, Polonara G, Uguccioni L, Quaranta A, Balardi L, Barbarossa A, Stronati G, Guerra F, Chiocchi M, Francone M, Esposito A, and Schicchi N
- Subjects
- Humans, Tomography, X-Ray Computed, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease diagnostic imaging
- Abstract
A cardiac lesion detected at ultrasonography might turn out to be a normal structure, a benign tumor or rarely a malignancy, and lesion characterization is very important to appropriately manage the lesion itself. The exact relationship of the mass with coronary arteries and the knowledge of possible concomitant coronary artery disease are necessary preoperative information. Moreover, the increasingly performed coronary CT angiography to evaluate non-invasively coronary artery disease leads to a rising number of incidental findings. Therefore, CT and MRI are frequently performed imaging modalities when echocardiography is deemed insufficient to evaluate a lesion. A brief comprehensive overview about diagnostic radiological imaging and the clinical background of cardiac masses and pseudomasses is reported.
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- 2023
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249. Primary emotional systems, childhood trauma, and suicidal ideation in youths with bipolar disorders.
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Janiri D, Moccia L, Montanari S, Simonetti A, Conte E, Chieffo D, Monti L, Kotzalidis GD, Janiri L, and Sani G
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- Adult, Child, Humans, Adolescent, Suicidal Ideation, Bipolar Disorder diagnosis, Adverse Childhood Experiences, Child Abuse psychology, Suicide
- Abstract
Background: Bipolar disorders (BD) in youths are strongly associated with suicidal ideation. Childhood trauma is a prominent environmental stressor associated with both BD diagnosis and suicide. Primary emotional systems are altered in adult BD and may contribute to suicide risk in youths., Objective: The aim of this study was to investigate primary emotional systems distribution patterns and childhood trauma in youths' BD with and without suicidal ideation (BD-IS, BD-NIS)., Participants and Setting: We assessed 289 participants, 103 youths with DSM-5 BD and 186 healthy controls (HCs)., Methods: Primary emotional systems were obtained with Panksepp's Affective Neuroscience Personality Scale (ANPS), and history of childhood trauma using the Childhood Trauma Questionnaire (CTQ). Suicidal ideation was assessed through the Columbia Suicide Scale for the Rating of Suicide Severity (C-SSRS). The associations with suicidal ideation were tested using two different multivariate models., Results: Over 48 % of participants reported lifetime suicidal ideation and differed on clinical variables from BD-NIS. According to the first model (Wilk's Lambda = 0.72, p < 0.0001), BD-IS scored higher on Panksepp's ANGER and lower on PLAY and CARE than BD-NIS. Both BD-SI and BD-NSI scored higher on ANGER and SEEK and lower on PLAY and CARE than HCs. BD-IS reported more emotional abuse than BD-NIS. They also reported more emotional, sexual, and physical abuse, and emotional neglect than HCs. Only ANGER (OR = 1.13, 95 % CI = 1.01-1.26, Wald = 5.72) and CTQ-Emotional abuse (OR = 1.26, 95 % C.I. = 1.04-1.52, Wald = 5.72) independently predicted suicidal ideation., Conclusions: Findings support the importance of assessing primary emotional systems and childhood trauma, in particular emotional abuse, in youths with BD at risk for suicide., Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare., (Copyright © 2023. Published by Elsevier Ltd.)
- Published
- 2023
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250. Multiparametric cardiac magnetic resonance unveiling the mechanisms and early manifestations of anticancer drug cardiotoxicity.
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Francone M, Figliozzi S, Monti L, Loewe C, and Catapano F
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- Humans, Heart diagnostic imaging, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Cardiotoxicity, Antineoplastic Agents adverse effects
- Published
- 2023
- Full Text
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