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35,326 results on '"Kurosawa, A."'

205. Survival Prediction of Patients Who Were Terminally Ill Using the EORTC QLQ-C15-PAL Scores and Laboratory Test Values

Author

Chikako Matsumura, Nanako Koyama, Kaho Okuno, Nobuhiko Nakamura, Morito Sako, Hideo Kurosawa, Takehisa Nomura, Yuki Eguchi, Kazuki Ohba, and Yoshitaka Yano

Subjects
palliative care, quality of life, survival prediction, symptom cluster, symptom score, terminally ill cancer patient, Medicine (General), R5-920
Abstract

Background: Prognostics for patients with cancer is especially important for the supportive care of those who are terminally ill. We previously found that symptom scores as patient-reported outcomes (PROs)?such as dyspnea and fatigue scores?some biochemical parameters, the palliative performance scale (PPS) scores, and symptom clusters were useful prognostic factors; however, the predictability of a prognosis based on these factors remains unclear. Objective: To identify appropriate three-week survival predictive factor(s), in terms of performance, in patients who were terminally ill. Design: We collected symptom scores as PROs using the Japanese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL). Setting/Subjects: We used data from terminally ill patients with cancer who were hospitalized at the palliative care unit of the Higashisumiyoshi-Morimoto Hospital (Osaka, Japan) from June 2018 to December 2019 (n?=?130), as well as additional data obtained from the same clinical study from January to March 2020 (n?=?31). Measurements: To evaluate predictive performance, indices such as sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were calculated. Results: We found that the presence of a symptom cluster showed high sensitivity but low specificity and that a higher PPS value (>30) showed high specificity but low sensitivity, suggesting that these factors could provide relevant information for survival prognosis (less than or equal to three weeks). Conclusion: Symptom clusters obtained from patients is important for effective supportive care of those who are terminally ill.

Published
2023
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206. Metadiaphyseal proximal radial fracture around the bicipital tuberosity fixed using a volar distal ulna plate via the volar Henry approach: a case report

Author

Takanobu Higashi, MD, Makoto Mitani, MD, PhD, Isao Fujibayashi, MD, Akihiro Ohara, MD, Masaya Kusunose, MD, Takashi Kurosawa, MD, PhD, and Takuma Ozaki, MD, PhD

Subjects
Metadiaphyseal proximal radius fracture, Bicipital tuberosity, Radial shaft, Volar Henry approach, Distal ulna plate, Locking plate, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Published
2023
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207. Biden Administration’s Nuclear Posture Review: Analysis and Assessment

Author

Mitsuru Kurosawa

Subjects
Nuclear Posture Review, President biden, nuclear weapons, deterrence, arms control, declaratory policy, Nuclear engineering. Atomic power, TK9001-9401, International relations, JZ2-6530
Abstract

ABSTRACTThe Nuclear Posture Review (NPR) by the Biden Administration was published in October 2022. What is its focus and how should we evaluate it? How is it different from previous administrations? Does the NPR reflect Biden’s proactive statements before its publication? This article introduces and examines pressing issues of the international security environment and threat perceptions, nuclear deterrence, declaratory policy, arms control, and nuclear capability as reflected in the NPR. Analysis is presented from two aspects, military and diplomacy, as the NPR emphasizes to “put diplomacy first”. The military aspects of the NPR, to strengthen and modernize nuclear deterrence as the main role of nuclear weapons, is strongly emphasized. On the other hand, diplomatic aspects of the NPR are narrowly and superficially treated, and it does not include proactive proposals. Future NPRs should include military and diplomatic positions more equally.

Published
2023
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208. Mixed acinar-neuroendocrine carcinoma of the pancreas with positive for microsatellite instability: a case report and review of the literature

Author

Kenji Yoshino, Yosuke Kasai, Manabu Kurosawa, Atsushi Itami, and Kyoichi Takaori

Subjects
Mixed acinar-neuroendocrine carcinoma, Microsatellite instability-high tumors, Programmed cell death-1 monoclonal antibody, Surgery, RD1-811
Abstract

Abstract Background Mixed acinar-neuroendocrine carcinoma (MANEC) of the pancreas is a rare tumor. We report a case of successful surgical resection of expansively growing MANEC of the pancreas with microsatellite instability (MSI)-high. Case presentation The patient was an asymptomatic 65-year-old male. A computed tomography (CT) scan for a follow-up after treatment of pneumonia incidentally revealed a hypoenhancing 12-cm expansively growing tumor in the pancreatic body. An endoscopic ultrasound-guided fine-needle aspiration of the tumor suggested the diagnosis of MANEC. We performed distal pancreatectomy with combined resection of the spleen, left adrenal gland, transverse colon, small bowel, and stomach. The intraoperative findings showed that the tumor was capsular and was in contact with the SMA, SMV, and CA; however, obvious infiltration of these vessels was not observed..Pathological findings indicated MANEC with MSI-high. Among mismatch repair (MMR) gene proteins, PMS2 was lost and MLH1, MSH2, and MSH6 were retained. The tumor recurred 5 months after surgery. The patient was treated with gemcitabine plus nab-paclitaxel followed by pembrolizumab, which did not show objective response. Discussion This is the first report investigating MSI and MMR in MANEC. Standard chemotherapy has not been established for MANEC. Detection of MSI-high is essential since PD-1 monoclonal antibodies for MSI-high cases might be one of the good treatment options. Herein, we discuss the various cytomorphologic and clinical features of MANEC and present a brief review of the literatures. Conclusions The accumulation of data from additional cases is necessary to further evaluate this type of carcinoma and provide a standardized optimal therapy for MANEC.

Published
2023
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209. Differences between oscillometry measurements obtained by MostGraph-01 and MasterScreen-IOS in patients with asthma.

Author

Sonoko Harada, Norihiro Harada, Hitoshi Sasano, Yuki Tanabe, Masaki Kotajima, Yoshihiko Sato, Tomohito Takeshige, Yoko Katsura, Jun Ito, Ryo Atsuta, Hajime Kurosawa, and Kazuhisa Takahashi

Subjects
Medicine, Science
Abstract

BackgroundOscillometry devices (also termed forced oscillation technique) devices such as MasterScreen-IOS® (Jaeger, Hochberg, Germany) and MostGraph-01® (Chest, Tokyo, Japan) are useful for obtaining physiological assessments in patients with obstructive lung diseases, including asthma. However, as oscillometry measurements have not been fully compared between MasterScreen-IOS® and MostGraph-01® in patients with asthma, it is unknown whether there are differences in the measurements between the devices. This study aimed to determine whether there is any difference in oscillometry measurements obtained using the two devices in patients with asthma.MethodsOscillometry measurements obtained using MasterScreen-IOS® and MostGraph-01® were retrospectively evaluated in 95 patients with asthma at Juntendo University Hospital between October 2009 and November 2009.ResultsThere was a strong positive correlation in the measurements between the two devices. However, the values of R5, R20, ALX and Fres were lower when measured with MostGraph-01® than with MasterScreen-IOS®, and vice versa for the values of X5. The results were used in correction equations to convert oscillometry parameters measured using MasterScreen-IOS® to those measured using MostGraph-01®.ConclusionsTo our knowledge, this is the first report to compare MostGraph-01® and MasterScreen-IOS® devices using practical clinical data obtained in patients with asthma. The values obtained by both devices can be interpreted in a similar way, although there is slight variation. The conversion equations produced in this study may assist to compare the oscillometry measurements obtained by each of the two devices.

Published
2024
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210. Chinese Grammatical Correction Using BERT-based Pre-trained Model

Author

Wang, Hongfei, Kurosawa, Michiki, Katsumata, Satoru, and Komachi, Mamoru

Subjects
Computer Science - Computation and Language
Abstract

In recent years, pre-trained models have been extensively studied, and several downstream tasks have benefited from their utilization. In this study, we verify the effectiveness of two methods that incorporate a BERT-based pre-trained model developed by Cui et al. (2020) into an encoder-decoder model on Chinese grammatical error correction tasks. We also analyze the error type and conclude that sentence-level errors are yet to be addressed., Comment: 6 pages; AACL-IJCNLP 2020

Published
2020

211. High magnetic field ultrasound study of spin freezing in La$_{1.88}$Sr$_{0.12}$CuO$_4$

Author

Frachet, M., Benhabib, S., Vinograd, I., Wu, S. -F., Vignolle, B., Mayaffre, H., Krämer, S., Kurosawa, T., Momono, N., Oda, M., Chang, J., Proust, C., Julien, M. -H., and LeBoeuf, D.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

High-$T_{\rm{c}}$ cuprate superconductors host spin, charge and lattice instabilities. In particular, in the antiferromagnetic glass phase, over a large doping range, lanthanum based cuprates display a glass-like spin freezing with antiferromagnetic correlations. Previously, sound velocity anomalies in La$_{2-x}$Sr$_{x}$CuO$_4$ (LSCO) for hole doping $p\geq 0.145$ were reported and interpreted as arising from a coupling of the lattice to the magnetic glass [Frachet, Vinograd et al., Nat. Phys. 16, 1064-1068 (2020)]. Here we report both sound velocity and attenuation in LSCO $p=0.12$, i.e. at a doping level for which the spin freezing temperature is the highest. Using high magnetic fields and comparing with nuclear magnetic resonance (NMR) measurements, we confirm that the anomalies in the low temperature ultrasound properties of LSCO are produced by a coupling between the lattice and the spin glass. Moreover, we show that both sound velocity and attenuation can be simultaneously accounted for by a simple phenomenological model originally developed for canonical spin glasses. Our results point towards a strong competition between superconductivity and spin freezing, tuned by the magnetic field. A comparison of different acoustic modes suggests that the slow spin fluctuations have a nematic character., Comment: 12 pages, 8 figures

Published
2020
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212. Disentangling Intertwined Quantum States in a Prototypical Cuprate Superconductor

Author

Choi, J., Wang, Q., Jöhr, S., Christensen, N. B., Küspert, J., Bucher, D., Biscette, D., Hücker, M., Kurosawa, T., Momono, N., Oda, M., Ivashko, O., Zimmermann, M. v., Janoschek, M., and Chang, J.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science, Condensed Matter - Superconductivity
Abstract

Spontaneous symmetry breaking constitutes a paradigmatic classification scheme of matter. However, broken symmetry also entails domain degeneracy that often impedes identification of novel low symmetry states. In quantum matter, this is additionally complicated by competing intertwined symmetry breaking orders. A prime example is that of unconventional superconductivity and density-wave orders in doped cuprates in which their respective symmetry relation remains a key question. Using uniaxial pressure as a domain-selective stimulus in combination with x-ray diffraction, we unambiguously reveal that the fundamental symmetry of the charge order in the prototypical cuprate La$_{1.88}$Sr$_{0.12}$CuO$_4$ is characterized by uniaxial stripes. We further demonstrate the direct competition of this stripe order with unconventional superconductivity via magnetic field tuning. The stripy nature of the charge-density-wave state established by our study is a prerequisite for the existence of a superconducting pair-density-wave -- a theoretical proposal that clarifies the interrelation of intertwined quantum phases in unconventional superconductors -- and paves the way for its high-temperature realization., Comment: 6 pages, 4 figures, 9 supplementary figures

Published
2020

213. Rabi-Oscillation Spectroscopy of the Hyperfine Structure of Muonium Atoms

Author

Nishimura, S., Torii, H. A., Fukao, Y., Ito, T. U., Iwasaki, M., Kanda, S., Kawagoe, K., Kawall, D., Kawamura, N., Kurosawa, N., Matsuda, Y., Mibe, T., Miyake, Y., Saito, N., Sasaki, K., Sato, Y., Seo, S., Strasser, P., Suehara, T., Tanaka, K. S., Tanaka, T., Tojo, J., Toyoda, A., Ueno, Y., Yamanaka, T., Yamazaki, T., Yasuda, H., Yoshioka, T., and Shimomura, K.

Subjects
High Energy Physics - Experiment, Physics - Atomic Physics
Abstract

As a new method to determine the resonance frequency, Rabi-oscillation spectroscopy has been developed. In contrast to the conventional spectroscopy which draws the resonance curve, Rabi-oscillation spectroscopy fits the time evolution of the Rabi oscillation. By selecting the optimized frequency, it is shown that the precision is twice as good as the conventional spectroscopy with a frequency sweep. Furthermore, the data under different conditions can be treated in a unified manner, allowing more efficient measurements for systems consisting of a limited number of short-lived particles produced by accelerators such as muons. We have developed a fitting function that takes into account the spatial distribution of muonium and the spatial distribution of the microwave intensity to apply the new method to ground-state muonium hyperfine structure measurements at zero field. This was applied to the actual measurement data and the resonance frequencies were determined under various conditions. The result of our analysis gives $\nu_{\rm HFS}=4\ 463\ 301.61 \pm 0.71\ {\rm kHz}$, which is the world's highest precision under zero field conditions., Comment: 6 pages, 5 figures

Published
2020
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214. Production of $\pi^0$ and $\eta$ mesons in U$+$U collisions at $\sqrt{s_{_{NN}}}=192$ GeV

Author

Acharya, U., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alexander, J., Aoki, K., Apadula, N., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bannier, B., Barish, K. N., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butsyk, S., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Christiansen, P., Chujo, T., Cianciolo, V., Cole, B. A., Connors, M., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Do, J. H., D'Orazio, L., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Engelmore, T., Enokizono, A., Esha, R., Esumi, S., Eyser, K. O., Fadem, B., Fan, W., Fields, D. E., Finger, M., Finger, Jr., M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Giordano, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hasegawa, S., Hashimoto, K., Hayano, R., He, X., Hemmick, T. K., Hester, T., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ichihara, T., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, K. S., Jouan, D., Jumper, D. S., Kamin, J., Kanda, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Khatiwada, A., Kijima, K. M., Kim, C., Kim, D. J., Kim, E. -J., Kim, Y. -J., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Krizek, F., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lai, Y. S., Lajoie, J. G., Larionova, D., Larionova, M., Lebedev, A., Lee, D. M., Lee, G. H., Lee, J., Lee, K. B., Lee, K. S., Lee, S. H., Leitch, M. J., Leitgab, M., Lewis, B., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Lökös, S., Lynch, D., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mibe, T., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Mohanty, A. K., Mohapatra, S., Moon, T., Morrison, D. P., Morrow, S. I., Moskowitz, M., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novák, T., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oide, H., Okada, K., Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, I. H., Park, S., Park, S. K., Pate, S. F., Patel, L., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pisani, R. P., Pun, A., Purschke, M. L., Qu, H., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Runchey, J., Ryu, M. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Sen, A., Seto, R., Sett, P., Sharma, D., Shaver, A., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Smith, K. L., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Stone, M. R., Sugitate, T., Sukhanov, A., Sun, J., Sun, X., Sun, Z., Takahara, A., Taketani, A., Tanaka, Y., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tennant, E., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wu, Y., Wysocki, M., Xia, B., Xu, Q., Yamaguchi, Y. L., Yanovich, A., Yokkaichi, S., Yoon, I., You, Z., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., Zhou, S., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The PHENIX experiment at the Relativistic Heavy Ion Collider measured $\pi^0$ and $\eta$ mesons at midrapidity in U$+$U collisions at $\sqrt{s_{_{NN}}}=192$ GeV in a wide transverse momentum range. Measurements were performed in the $\pi^0(\eta)\rightarrow\gamma\gamma$ decay modes. A strong suppression of $\pi^0$ and $\eta$ meson production at high transverse momentum was observed in central U$+$U collisions relative to binary scaled $p$$+$$p$ results. Yields of $\pi^0$ and $\eta$ mesons measured in U$+$U collisions show similar suppression pattern to the ones measured in Au$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV for similar numbers of participant nucleons. The $\eta$/$\pi^0$ ratios do not show dependence on centrality or transverse momentum, and are consistent with previously measured values in hadron-hadron, hadron-nucleus, nucleus-nucleus, and $e^+e^-$ collisions., Comment: 403 authors from 72 institutions, 13 pages, 6 figures, 7 tables, 2012 data. v2 is version accepted by Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2020
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215. Production of $b\bar{b}$ at forward rapidity in $p$+$p$ collisions at $\sqrt{s}=510$ GeV

Author

Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Csanád, M., Csörgő, T., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Finger, Jr., M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Gal, C., Gallus, P., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hasegawa, S., He, X., Hemmick, T. K., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, E., Joo, K. S., Jouan, D., Jumper, D. S., Kang, J. H., Kang, J. S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kihara, K., Kim, C., Kim, D. H., Kim, D. J., Kim, E. -J., Kim, H. -J., Kim, M., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Koster, J., Kotov, D., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Larionova, D., Larionova, M., Lebedev, A., Lee, K. B., Lee, S. H., Leitch, M. J., Leitgab, M., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Lökös, S., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mignerey, A. C., Miller, A. J., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, S., Pate, S. F., Patel, L., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, X., Sun, Z., Sziklai, J., Takahara, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, M., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Velkovska, J., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wu, Y., Wysocki, M., Xia, B., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yanovich, A., Yoon, I., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The cross section of bottom quark-antiquark ($b\bar{b}$) production in $p$+$p$ collisions at $\sqrt{s}=510$ GeV is measured with the PHENIX detector at the Relativistic Heavy Ion Collider. The results are based on the yield of high mass, like-sign muon pairs measured within the PHENIX muon arm acceptance ($1.2<|y|<2.2$). The $b\bar{b}$ signal is extracted from like-sign dimuons by utilizing the unique properties of neutral $B$ meson oscillation. We report a differential cross section of $d\sigma_{b\bar{b}\rightarrow \mu^\pm\mu^\pm}/dy = 0.16 \pm 0.01~(\mbox{stat}) \pm 0.02~(\mbox{syst}) \pm 0.02~(\mbox{global})$ nb for like-sign muons in the rapidity and $p_T$ ranges $1.2<|y|<2.2$ and $p_T>1$ GeV/$c$, and dimuon mass of 5--10 GeV/$c^2$. The extrapolated total cross section at this energy for $b\bar{b}$ production is $13.1 \pm 0.6~(\mbox{stat}) \pm 1.5~(\mbox{syst}) \pm 2.7~(\mbox{global})~\mu$b. The total cross section is compared to a perturbative quantum chromodynamics calculation and is consistent within uncertainties. The azimuthal opening angle between muon pairs from $b\bar{b}$ decays and their $p_T$ distributions are compared to distributions generated using {\sc ps pythia 6}, which includes next-to-leading order processes. The azimuthal correlations and pair $p_T$ distribution are not very well described by {\sc pythia} calculations, but are still consistent within uncertainties. Flavor creation and flavor excitation subprocesses are favored over gluon splitting., Comment: 360 authors from 69 institutions, 13 pages, 11 figures, 2 tables, 2013 data. v2 is version accepted for publication in Physical Review D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2020
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216. Measurement of jet-medium interactions via direct photon-hadron correlations in Au$+$Au and $d$$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

Acharya, U., Adare, A., Afanasiev, S., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Al-Bataineh, H., Alexander, J., Al-Ta'ani, H., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E. C., Atomssa, E. T., Averbeck, R., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Bannier, B., Barish, K. N., Bassalleck, B., Basye, A. T., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bhom, J. H., Bichon, L., Bickley, A. A., Black, D., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Camacho, C. M., Campbell, S., Roman, V. Canoa, Caringi, A., Castera, P., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Choi, S., Choudhury, R. K., Christiansen, P., Chujo, T., Chung, P., Chvala, O., Cianciolo, V., Citron, Z., Cole, B. A., del Valle, Z. Conesa, Connors, M., Constantin, P., Cronin, N., Crossette, N., Csanád, M., Csörgő, T., Dahms, T., Dairaku, S., Danchev, I., Das, K., Datta, A., Daugherity, M. S., David, G., Dayananda, M. K., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dharmawardane, K. V., Dietzsch, O., Ding, L., Dion, A., Do, J. H., Donadelli, M., D'Orazio, L., Drapier, O., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Dutta, D., Edwards, S., Efremenko, Y. V., Ellinghaus, F., Engelmore, T., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Eyser, K. O., Fadem, B., Fan, W., Fields, D. E., Finger, M., Finger, Jr., M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S. L., Fraenkel, Z., Frantz, J. E., Franz, A., Frawley, A. D., Fujiwara, K., Fukao, Y., Fusayasu, T., Gainey, K., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Giordano, F., Glenn, A., Gong, H., Gong, X., Gonin, M., Goto, Y., de Cassagnac, R. Granier, Grau, N., Greene, S. V., Grim, G., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guo, L., Gustafsson, H. -Å., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamblen, J., Han, R., Han, S. Y., Hanks, J., Hartouni, E. P., Hasegawa, S., Hashimoto, K., Haslum, E., Hayano, R., Hayashi, S., He, X., Heffner, M., Hemmick, T. K., Hester, T., Hill, J. C., Hodges, A., Hohlmann, M., Hollis, R. S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hornback, D., Huang, J., Huang, S., Ichihara, T., Ichimiya, R., Ide, J., Iinuma, H., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Isinhue, A., Isobe, T., Issah, M., Isupov, A., Ivanishchev, D., Iwanaga, Y., Jacak, B. V., Javani, M., Ji, Z., Jia, J., Jiang, X., Jin, J., Johnson, B. M., Jones, T., Joo, K. S., Jouan, D., Jumper, D. S., Kajihara, F., Kametani, S., Kamihara, N., Kamin, J., Kaneti, S., Kang, B. H., Kang, J. H., Kang, J. S., Kapustinsky, J., Karatsu, K., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A. V., Kempel, T., Key, J. A., Khachatryan, V., Khandai, P. K., Khanzadeev, A., Khatiwada, A., Kijima, K. M., Kikuchi, J., Kim, A., Kim, B. I., Kim, C., Kim, D. H., Kim, D. J., Kim, E., Kim, E. -J., Kim, H. J., Kim, K. -B., Kim, S. H., Kim, Y. -J., Kim, Y. K., Kincses, D., Kinney, E., Kiriluk, K., Kiss, Á., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Kochenda, L., Komatsu, Y., Komkov, B., Konno, M., Koster, J., Kotchetkov, D., Kotov, D., Kozlov, A., Král, A., Kravitz, A., Krizek, F., Kunde, G. J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G. S., Lacey, R., Lai, Y. S., Lajoie, J. G., Larionova, D., Larionova, M., Lebedev, A., Lee, B., Lee, D. M., Lee, J., Lee, K., Lee, K. B., Lee, K. S., Lee, S. H., Lee, S. R., Leitch, M. J., Leite, M. A. L., Leitgab, M., Leitner, E., Lenzi, B., Lewis, B., Lewis, N. A., Li, X., Lichtenwalner, P., Liebing, P., Lim, S. H., Levy, L. A. Linden, Liška, T., Litvinenko, A., Liu, H., Liu, M. X., Lökös, S., Love, B., Luechtenborg, R., Lynch, D., Maguire, C. F., Majoros, T., Makdisi, Y. I., Makek, M., Malakhov, A., Malik, M. D., Manion, A., Manko, V. I., Mannel, E., Mao, Y., Masui, H., Masumoto, S., Matathias, F., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mibe, T., Midori, J., Mignerey, A. C., Mikeš, P., Miki, K., Milov, A., Mishra, D. K., Mishra, M., Mitchell, J. T., Mitrankov, Iu., Miyachi, Y., Miyasaka, S., Mohanty, A. K., Mohapatra, S., Moon, H. J., Moon, T., Morino, Y., Morreale, A., Morrison, D. P., Morrow, S. I., Moskowitz, M., Motschwiller, S., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagamiya, S., Nagle, J. L., Naglis, M., Nagy, M. I., Nakagawa, I., Nakamiya, Y., Nakamura, K. R., Nakamura, T., Nakano, K., Nam, S., Nattrass, C., Nederlof, A., Nelson, S., Netrakanti, P. K., Newby, J., Nguyen, M., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Nukariya, A., Nyanin, A. S., Oakley, C., Obayashi, H., O'Brien, E., Oda, S. X., Ogilvie, C. A., Oka, M., Okada, K., Onuki, Y., Osborn, J. D., Oskarsson, A., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B. H., Park, I. H., Park, J., Park, S., Park, S. K., Park, W. J., Pate, S. F., Patel, L., Patel, M., Pei, H., Peng, J. -C., Peng, W., Pereira, H., Perepelitsa, D. V., Peresedov, V., Peressounko, D. Yu., PerezLara, C. E., Petti, R., Pinkenburg, C., Pisani, R. P., Proissl, M., Pun, A., Purschke, M. L., Purwar, A. K., Qu, H., Radzevich, P. V., Rak, J., Rakotozafindrabe, A., Ramasubramanian, N., Ravinovich, I., Read, K. F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Roche, G., Rolnick, S. D., Rosati, M., Rosen, C. A., Rosendahl, S. S. E., Rosnet, P., Rukoyatkin, P., Runchey, J., Ružička, P., Ryu, M. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakashita, K., Sako, H., Samsonov, V., Sano, M., Sano, S., Sarsour, M., Sato, S., Sato, T., Sawada, S., Sedgwick, K., Seele, J., Seidl, R., Semenov, A. Yu., Sen, A., Seto, R., Sett, P., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shoji, K., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Silvestre, C., Sim, K. S., Singh, B. K., Singh, C. P., Singh, V., Skolnik, M., Slunečka, M., Smith, K. L., Solano, S., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Sparks, N. A., Stankus, P. W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S. P., Sugitate, T., Sukhanov, A., Sun, J., Sun, X., Sun, Z., Sziklai, J., Takagui, E. M., Takahara, A., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarján, P., Tennant, E., Themann, H., Thomas, D., Thomas, T. L., Todoroki, T., Togawa, M., Toia, A., Tomášek, L., Tomášek, M., Torii, H., Towell, R. S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ueda, Y., Ujvari, B., Vale, C., Valle, H., van Hecke, H. W., Vargyas, M., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Vértesi, R., Vinogradov, A. A., Virius, M., Voas, B., Vossen, A., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y. S., Wei, F., Wei, R., Wessels, J., Whitaker, S., White, S. N., Winter, D., Wolin, S., Wong, C. P., Wood, J. P., Woody, C. L., Wright, R. M., Wu, Y., Wysocki, M., Xia, B., Xie, W., Xu, Q., Yamaguchi, Y. L., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., You, Z., Young, G. R., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zhang, C., Zharko, S., Zhou, S., Zolin, L., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

We present direct photon-hadron correlations in 200 GeV/A Au$+$Au, $d$$+$Au and $p$$+$$p$ collisions, for direct photon $p_T$ from 5--12 GeV/$c$, collected by the PHENIX Collaboration in the years from 2006 to 2011. We observe no significant modification of jet fragmentation in $d$$+$Au collisions, indicating that cold nuclear matter effects are small or absent. Hadrons carrying a large fraction of the quark's momentum are suppressed in Au$+$Au compared to $p$$+$$p$ and $d$$+$Au. As the momentum fraction decreases, the yield of hadrons in Au$+$Au increases to an excess over the yield in $p$$+$$p$ collisions. The excess is at large angles and at low hadron $p_T$ and is most pronounced for hadrons associated with lower momentum direct photons. Comparison to theoretical calculations suggests that the hadron excess arises from medium response to energy deposited by jets., Comment: 578 authors from 80 institutions, 11 pages, 7 figures, data from 2007, 2008, 2010, and 2011. v2 is version accepted for publication in Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2020
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217. Polarization and cross section of midrapidity J/$\psi$ production in proton-proton collisions at $\sqrt{s}=510$ GeV

Author

Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Csanád, M., Csörgő, T., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Finger, Jr., M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Gal, C., Gallus, P., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hasegawa, S., He, X., Hemmick, T. K., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, E., Joo, K. S., Jouan, D., Jumper, D. S., Kang, J. H., Kang, J. S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kihara, K., Kim, C., Kim, D. H., Kim, D. J., Kim, E. -J., Kim, H. -J., Kim, M., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Koster, J., Kotov, D., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Larionova, D., Larionova, M., Lebedev, A., Lee, K. B., Lee, S. H., Leitch, M. J., Leitgab, M., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Lökös, S., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mignerey, A. C., Miller, A. J., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Nihashi, M., Niida, T., Nouicer, R., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, S., Pate, S. F., Patel, L., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, X., Sun, Z., Sziklai, J., Takahara, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, M., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Velkovska, J., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Watanabe, D., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wu, Y., Wysocki, M., Xia, B., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yanovich, A., Yoon, I., Younus, I., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., and Zou, L.

Subjects
High Energy Physics - Experiment
Abstract

The PHENIX experiment has measured the spin alignment for inclusive $J/\psi\rightarrow e^{+}e^{-}$ decays in $p$+$p$ collisions at $\sqrt{s}=510$ GeV at midrapidity. The angular distributions have been measured in three different polarization frames, and the three decay angular coefficients have been extracted in a full two-dimensional analysis. Previously, PHENIX saw large longitudinal net polarization at forward rapidity at the same collision energy. This analysis at midrapidity, complementary to the previous PHENIX results, sees no sizable polarization in the measured transverse momentum range of $0.0

Published
2020
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218. New precise spectroscopy of the hyperfine structure in muonium with a high-intensity pulsed muon beam

Author

Kanda, S., Fukao, Y., Ikedo, Y., Ishida, K., Iwasaki, M., Kawall, D., Kawamura, N., Kojima, K. M., Kurosawa, N., Matsuda, Y., Mibe, T., Miyake, Y., Nishimura, S., Saito, N., Sato, Y., Seo, S., Shimomura, K., Strasser, P., Tanaka, K. S., Tanaka, T., Torii, H. A., Toyoda, A., and Ueno, Y.

Subjects
High Energy Physics - Experiment, Physics - Atomic Physics, Physics - Instrumentation and Detectors
Abstract

A hydrogen-like atom consisting of a positive muon and an electron is known as muonium. It is a near-ideal two-body system for a precision test of bound-state theory and fundamental symmetries. The MuSEUM collaboration performed a new precision measurement of the muonium ground-state hyperfine structure at J-PARC using a high-intensity pulsed muon beam and a high-rate capable positron counter. The resonance of hyperfine transition was successfully observed at a near-zero magnetic field, and the muonium hyperfine structure interval of ${\nu}_{\text{HFS}}$ = 4.463302(4) GHz was obtained with a relative precision of 0.9 ppm. The result was consistent with the previous ones obtained at Los Alamos National Laboratory and the current theoretical calculation. We present a demonstration of the microwave spectroscopy of muonium for future experiments to achieve the highest precision., Comment: 7 pages, 8 figures

Published
2020
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219. Measurement of charged pion double spin asymmetries at midrapidity in longitudinally polarized $p$$+$$p$ collisions at $\sqrt{s}=510$ GeV

Author

Acharya, U. A., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Black, D., Bok, J. S., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Csanád, M., Csörgő, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Finger, Jr., M., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Gal, C., Gallus, P., Gamez, E. A., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hasegawa, S., Haseler, T. O. S., He, X., Hemmick, T. K., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Ishimaru, S., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, E., Joo, K. S., Jouan, D., Jumper, D. S., Kang, J. H., Kang, J. S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kihara, K., Kim, C., Kim, D. H., Kim, D. J., Kim, E. -J., Kim, H. -J., Kim, M., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Koster, J., Kotov, D., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Lebedev, A., Lee, K. B., Lee, S. H., Leitch, M. J., Leitgab, M., Leung, Y. H., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Lökös, S., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mignerey, A. C., Miller, A. J., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagashima, K., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Nihashi, M., Niida, T., Nishitani, R., Nouicer, R., Novák, T., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, S., Pate, S. F., Patel, L., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Scarlett, C. Y., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, X., Sun, Z., Suzuki, S., Sziklai, J., Takahara, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, M., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Velkovska, J., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Wang, Z., Watanabe, D., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wu, Y., Wysocki, M., Xia, B., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yanovich, A., Yoo, J. H., Yoon, I., Younus, I., Yu, H., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured the longitudinal double spin asymmetries, $A_{LL}$, for charged pions at midrapidity ($|\eta|<0.35$) in longitudinally polarized $p$$+$$p$ collisions at $\sqrt{s}=510$ GeV. These measurements are sensitive to the gluon spin contribution to the total spin of the proton in the parton momentum fraction $x$ range between 0.04 and 0.09. One can infer the sign of the gluon polarization from the ordering of pion asymmetries with charge alone. The asymmetries are found to be consistent with global quantum-chromodynamics fits of deep-inelastic scattering and data at $\sqrt{s}=200$ GeV, which show a nonzero positive contribution of gluon spin to the proton spin., Comment: 360 authors, 8 pages, 6 figures, 1 table, 2013 data. v2 is version accepted for publication in Physical Review D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2020
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220. Impact Ejecta near the Impact Point Observed using Ultra-high-speed Imaging and SPH Simulations, and a Comparison of the Two Methods

Author

Okamoto, Takaya, Kurosawa, Kosuke, Genda, Hidenori, and Matsui, Takafumi

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

High-speed impact ejecta at velocities comparable to the impact velocity are expected to contribute to material transport between planetary bodies and deposition of ejecta far from the impact crater. We investigated the behavior of high-speed ejecta produced at angles of 45 and 90 degrees, using both experimental and numerical methods. The experimental system developed at the Planetary Exploration Research Center of Chiba Institute of Technology (Japan) allowed us to observe the initial growth of the ejecta. We succeeded in imaging high-speed ejecta at 0.2 $\mathrm{{\mu}}$s intervals for impacts of polycarbonate projectiles of 4.8 mm diameter onto a polycarbonate plate at an impact velocity of ~4 km s$^{-1}$. Smoothed particle hydrodynamics (SPH) simulations of various numerical resolutions were conducted for the same impact conditions as pertaining to the experiments. We compared the morphology and velocities of the ejecta for the experiments and simulations, and we confirmed a close match for high-resolution simulations (with $\geq10^6$ SPH particles representing the projectile). According to the ejecta velocity distributions obtained from our high-resolution simulations, the ejection velocities of the high-speed ejecta for oblique impacts are much greater than those for vertical impacts. The translational motion of penetrating projectiles parallel to the target surface in oblique impacts could cause long-term, sustained acceleration at the root of the ejecta., Comment: 33 pages, 16 figures, 1 supporting information, accepted for publication in Journal of Geophysical Research: Planets

Published
2020
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221. Generating metal-polluting debris in white dwarf planetary systems from small-impact crater ejecta

Author

Veras, Dimitri and Kurosawa, Kosuke

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Metal pollution in white dwarf photospheres originates from the accretion of some combination of planets, moons, asteroids, comets, boulders, pebbles and dust. When large bodies reside in dynamically stagnant locations -- unable themselves to pollute nor even closely approach the white dwarf -- then smaller reservoirs of impact debris may become a complementary or the primary source of metal pollutants. Here, we take a first step towards exploring this possibility by computing limits on the recoil mass that escapes the gravitational pull of the target object following a single impact onto an atmosphere-less surface. By considering vertical impacts only with the full-chain analytical prescription from Kurosawa & Takada (2019), we provide lower bounds for the ejected mass for basalt, granite, iron and water-rich target objects across the radii range 10^{0-3} km. Our use of the full-chain prescription as opposed to physical experiments or hydrocode simulations allows us to quickly sample a wide range of parameter space appropriate to white dwarf planetary systems. Our numerical results could be used in future studies to constrain freshly-generated small debris reservoirs around white dwarfs given a particular planetary system architecture, bombardment history, and impact geometries., Comment: Accepted for publication in MNRAS

Published
2020
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222. Nature of the charge-density wave excitations in cuprates

Author

lin, J. Q., Miao, H., Mazzone, D. G., Gu, G. D., Nag, A., Walters, A. C., Garcia-Fernandez, M., Barbour, A., Pelliciari, J., Jarrige, I., Oda, M., Kurosawa, K., Momono, N., Zhou, K., Bisogni, V., Liu, X., and Dean, M. P. M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

The discovery of charge-density wave (CDW)-related effects in the resonant inelastic x-ray scattering (RIXS) spectra of cuprates holds the tantalizing promise of clarifying the interactions that stabilize the electronic order. Here, we report a comprehensive RIXS study of La2-xSrxCuO4 (LSCO) finding that CDW effects persist up to a remarkably high doping level of x = 0.21 before disappearing at x = 0.25. The inelastic excitation spectra remain essentially unchanged with doping despite crossing a topological transition in the Fermi surface. This indicates that the spectra contain little or no direct coupling to electronic excitations near the Fermi surface, rather they are dominated by the resonant cross-section for phonons and CDW-induced phonon-softening. We interpret our results in terms of a CDW that is generated by strong correlations and a phonon response that is driven by the CDW-induced modification of the lattice., Comment: 7 pages including references in long format

Published
2020
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223. Charge density waves in cuprate superconductors beyond the critical doping

Author

Miao, H., Fabbris, G., Koch, R. J., Mazzone, D. G., Nelson, C. S., Acevedo-Esteves, R., Li, Y., Gu, G. D., Yilmaz, T., Kaznatcheev, K., Vescovo, E., Oda, M., Kurosawa, K., Momono, N., Assefa, T. A., Robinson, I. K., Bozin, E., Tranquada, J. M., Johnson, P. D., and Dean, M. P. M.

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract

The unconventional normal-state properties of the cuprates are often discussed in terms of emergent electronic order that onsets below a putative critical doping of xc = 0.19. Charge-density wave (CDW) correlations represent one such order; however, experimental evidence for such order generally spans a limited range of doping that falls short of the critical value xc, leading to questions regarding its essential relevance. Here, we use x-ray diffraction to demonstrate that CDW correlations in La2-xSrxCuO4 persist up to a doping of at least x = 0.21. The correlations show strong changes through the superconducting transition, but no obvious discontinuity through xc = 0.19, despite changes in Fermi surface topology and electronic transport at this doping. These results demonstrate the interaction between CDWs and superconductivity even in overdoped cuprates and prompt a reconsideration of the role of CDW correlations in the high-temperature cuprate phase diagram., Comment: 8 pages + 5 pages of supplemental material; accepted in npj Quantum Materials

Published
2020
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224. Coexistence of the Kondo effect and spin glass physics in Fe-doped NbS$_2$

Author

Nobukane, H., Tabata, Y., Kurosawa, T., Sakabe, D., and Tanda, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We report the coexistence of the Kondo effect and spin glass behavior in Fe-doped NbS$_2$ single crystals. The Fe$_x$NbS$_2$ shows the resistance minimum and negative magnetoresistance due to the Kondo effect, and exhibits no superconducting behavior at low temperatures. The resistance curve follows a numerical renormalization-group theory using the Kondo temperature $T_K =12.3$~K for $x=0.01$ as evidence of Kondo effect. Scanning tunneling microscope/spectroscopy (STM/STS) revealed the presence of Fe atoms near sulfur atoms and asymmetric spectra. The magnetic susceptibility exhibits a feature of spin glass. The static critical exponents determined by the universal scaling of the nonlinear part of the susceptibility suggest a three-dimensional Heisenberg spin glass. The doped-Fe atoms in the intra- and inter-layers revealed by the X-ray result can realize the coexistence of the Kondo effect and spin glass.

Published
2020
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225. Irrationality exponents of generalized Hone series

Author

Duverney, Daniel, Kurosawa, Takeshi, and Shiokawa, Iekata

Subjects
Mathematics - Number Theory, 11J82, 11J70
Abstract

We compute the exact irrationality exponents of certain series of rational numbers, first studied in a special case by Hone, by transforming them into suitable continued fractions.

Published
2020

227. Finite element analysis to clarify stress on articular surface of thumb carpometacarpal joint in static loading conditions by using CT images

Author

Akihiro KUROSAWA, Masahiro HIGUCHI, Hiroshi TACHIYA, Kaoru TADA, Atsuro MURAI, Atsuya TAMAI, and Hiroki KAWASHIMA

Subjects
thumb, carpometacarpal joint, finite element analysis, osteoarthritis, biomechanics, Science, Mechanical engineering and machinery, TJ1-1570
Abstract

Analyzing the biomechanics of the thumb carpometacarpal (CMC) joint is essential for elucidating the etiology of osteoarthritis (OA) and for developing a mechanics-based treatment. This study aimed to identify the areas where the peak stress in the cortical bone is likely to occur during thumb motion. We also investigated whether the stress in the first metacarpal and trapezium differ. CT scan was performed on 11 healthy adult men during flexion and abduction. 3D CMC joint models were created from CT images and then finite element (FE) models under the static compressive force in the bone axial direction of the first metacarpal were constructed. As a result, the peak stress in the cortical bone of the first metacarpal tended to be concentrated in the volar–central region, and that of the trapezium was uniformly distributed across the entire articular surface. Furthermore, the trapezium had higher stress in the cortical bone than the first metacarpal. These results suggest that the volar–central region of the first metacarpal is easily worn, and that the trapezium is evenly worn. These results also suggest that wear is likely to progress from the trapezium.

Published
2023
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228. A sequential one-pot approach for rapid and convenient characterization of putative restriction-modification systems

Author

Yi Zhang, Yoshihiro Takaki, Yukari Yoshida-Takashima, Satoshi Hiraoka, Kanako Kurosawa, Takuro Nunoura, and Ken Takai

Subjects
protein function, virus-host interactions, protein-DNA interactions, restriction-modification system, fluorescence assays, enzymes, Microbiology, QR1-502
Abstract

ABSTRACT With the advance of high-throughput sequencing, the molecular basis of coevolutionary interaction between viruses and host microorganisms is predominantly elucidated by in silico genomic analyses, which revealed potential communication of genetic materials related to microbial immune systems such as the restriction-modification (R-M) system. However, the sequence-dependent information is often insufficient to output a conclusive argument without biochemical characterizations, particularly for homologs of rare genes considered less accurately annotated. We proposed a 1-day and one-pot workflow covering in vitro protein synthesis and enzymatic assays to confirm the exact function of putative R-M genes only with manual pipetting operations of microliter-scale liquids. The proof-of-demonstration experiments mainly focused on a series of putative R-M enzymes from our recently found deep-sea temperate bacteriophage and its host bacterium. Two new restriction endonucleases and two new methyltransferases with respective unambiguous substrate specificities, superior catalytic performance, or unique sequence preferences were quickly identified. A frequent discrepancy between sequence similarity search and single-molecule methylation-sensitive sequencing toward the prediction of recognition motifs can get settled with the established direct biochemical characterization. The proposed approach under the cell-free one-pot concept allows for preliminary characterizations of diverse categories (e.g., Types I, II, and III) of putative R-M systems at most laboratories with minimum equipment and time costs.IMPORTANCEThe elucidation of the molecular basis of virus-host coevolutionary interactions is boosted with state-of-the-art sequencing technologies. However, the sequence-only information is often insufficient to output a conclusive argument without biochemical characterizations. We proposed a 1-day and one-pot approach to confirm the exact function of putative restriction-modification (R-M) genes that presumably mediate microbial coevolution. The experiments mainly focused on a series of putative R-M enzymes from a deep-sea virus and its host bacterium. The results quickly unveiled unambiguous substrate specificities, superior catalytic performance, and unique sequence preferences for two new restriction enzymes (capable of cleaving DNA) and two new methyltransferases (capable of modifying DNA with methyl groups). The reality of the functional R-M system reinforced a model of mutually beneficial interactions with the virus in the deep-sea microbial ecosystem. The cell culture-independent approach also holds great potential for exploring novel and biotechnologically significant R-M enzymes from microbial dark matter.

Published
2023
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229. Vacuum cleaving of superconducting niobium tips to optimize noise filtering and with adjustable gap size for scanning tunneling microscopy

Author

Carolina A. Marques, Aleš Cahlík, Berk Zengin, Tohru Kurosawa, and Fabian D. Natterer

Subjects
Vacuum cleaving of superconducting niobium tips to optimize noise filtering and with adjustable gap size for scanning tunneling microscopy, Science
Abstract

Superconducting (SC) tips for scanning tunneling microscopy (STM) can enhance a wide range of surface science studies because they offer exquisite energy resolution, allow the study of Josephson tunneling, or provide spatial contrast based on the local interaction of the SC tip with the sample. The appeal of a SC tip is also practical. An SC gap can be used to characterize and optimize the noise of a low-temperature apparatus. Unlike typical samples, SC tips can be made with less ordered materials, such as from SC polycrystalline wires or by coating a normal metal tip with a superconductor. Those recipes either require additional laboratory infrastructure or are carried out in ambient conditions, leaving an oxidized tip behind. Here, we revisit the vacuum cleaving of an Nb wire to prepare fully gapped tips in an accessible one-step procedure. To show their utility, we measure the SC gap of Nb on Au(111) to determine the base temperature of our microscope and to optimize its RF filtering. The deliberate coating of the Nb tip with Au fully suppresses the SC gap and we show how sputtering with Ar+ ions can be used to gradually recover the gap, promising tunability for tailored SC gaps sizes. • Oxide free superconducting STM tips • RF filter optimization

Published
2023
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230. Comparison of paediatric basic life support guidelines endorsed by member councils of Resuscitation Council of Asia

Author

Gene Y. Ong, Hiroshi Kurosawa, Takanari Ikeyama, June Dong Park, Poomiporn Katanyuwong, Olivia C.F. Reyes, En-Ting Wu, Kam Lun Ellis Hon, Ian K. Maconochie, Lindsay N. Shepard, Vinay M. Nadkarni, and Kee Chong Ng

Subjects
Cardiopulmonary resuscitation, Life support care, Pediatrics, Practice guidelines as topic, Specialties of internal medicine, RC581-951
Abstract

Background: Paediatric cardiac arrest outcomes, especially for infants, remain poor. Due to different training, resource differences, and historical reasons, paediatric cardiac arrest algorithms for various Asia countries vary. While there has been a common basic life support algorithm for adults by the Resuscitation Council of Asia (RCA), there is no common RCA algorithm for paediatric life support.We aimed to review published paediatric life support guidelines from different Asian resuscitation councils. Methods: Pubmed and Google Scholar search were performed for published paediatric basic and advanced life support guidelines from January 2015 to June 2023. Paediatric representatives from the Resuscitation Council of Asia were sought and contacted to provide input from September 2022 till June 2023. Results: While most of the components of published paediatric life support algorithms of Asian countries are similar, there are notable variations in terms of age criteria for recommended use of adult basic life support algorithms in the paediatric population less than 18 years old, recommended paediatric chest compression depth targets, ventilation rates post-advanced airway intra-arrest, and first defibrillation dose for shockable rhythms in paediatric cardiac arrest. Conclusion: This was an overview and mapping of published Asian paediatric resuscitation algorithms. It highlights similarities across paediatric life support guidelines in Asian countries. There were some differences in components of paediatric life support which highlight important knowledge gaps in paediatric resuscitation science. The minor differences in the paediatric life support guidelines endorsed by the member councils may provide a framework for prioritising resuscitation research and highlight knowledge gaps in paediatric resuscitation.

Published
2023
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231. Humoral response against spike protein enhanced by fifth and sixth COVID-19 mRNA vaccine in the uninfected and infected subjects

Author

Hideaki Kato, Takayuki Kurosawa, Kazuo Horikawa, Yayoi Kimura, Kei Miyakawa, Akihide Ryo, and Atsushi Goto

Subjects
Antibody, spike protein, nucleocapsid protein, SARS-CoV-2, COVID-19, chemiluminescent enzyme immunoassay, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract

ABSTRACTAntibody obtained by the coronavirus disease-19 (COVID-19) mRNA vaccine declines over time, and additional vaccinations are offered. It is not clear how repeated vaccination affects humoral immunity in uninfected individuals. We analyzed immunoglobulin G for spike protein (S-IgG) titers in COVID-19 uninfected and infected individuals vaccinated up to six times. The geometric mean S-IgG titers were 575.9 AU/mL and 369.0 AU/mL in those who received 6 and 5 doses less than 180 days after the last vaccination in uninfected subjects. In the 180–360 days after the last vaccination, the geometric mean S-IgG titers were 237.9 AU/mL and 128.6 AU/mL in the uninfected subjects who underwent five-dose and four-dose groups, respectively. Multivariate analysis showed that S-IgG titer increased 1.261-fold with each additional dose of mRNA vaccine. The S-IgG titers were 2.039-fold higher in the COVID-infected subjects compared to uninfected subjects. The positivity rate of nucleocapsid antibodies, suggesting a history of COVID-19, decreased 82% and 30% of COVID-infected cases after 180 and 360 days of infection, respectively. This result suggested that repeated vaccination with the COVID-19 mRNA vaccine may increase antibody titer in uninfected subjects.

Published
2023
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232. Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL

Author

Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, Yoshiki Yamaguchi, and Shoko Nishihara

Subjects
Arylsulfatase L, Rare disease, Missense variant, Stabilization energy, Sulfatase activity, Protein instability, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Rare diseases are estimated to affect 3.5%–5.9% of the population worldwide and are difficult to diagnose. Genome analysis is useful for diagnosis. However, since some variants, especially missense variants, are also difficult to interpret, tools to accurately predict the effect of missense variants are very important and needed. Here we developed a method, “VarMeter”, to predict whether a missense variant is damaging based on Gibbs free energy and solvent-accessible surface area calculated from the AlphaFold 3D protein model. We applied this method to the whole-exome sequencing data of 900 individuals with rare or undiagnosed disease in our in-house database, and identified four who were hemizygous for missense variants of arylsulfatase L (ARSL; known as the genetic cause of chondrodysplasia punctata 1, CPDX1). Two individuals had a novel Ser89 to Asn (Ser89Asn) or Arg469 to Trp (Arg469Trp) substitution, respectively predicted as “damaging” or “benign”; the other two had an Arg111 to His (Arg111His) or Gly117 to Arg (Gly117Arg) substitution, respectively predicted as “damaging” or “possibly damaging” and previously reported in patients showing clinical manifestations of CDPX1. Expression and analysis of the missense variant proteins showed that the predicted pathogenic variants (Ser89Asn, Arg111His, and Gly117Arg) had complete loss of sulfatase activity and reduced protease resistance due to destabilization of protein structure, while the predicted benign variant (Arg469Trp) had activity and protease resistance comparable to those of wild-type ARSL. The individual with the novel pathogenic Ser89Asn variant exhibited characteristics of CDPX1, while the individual with the benign Arg469Trp variant exhibited no such characteristics. These findings demonstrate that VarMeter may be used to predict the deleteriousness of variants found in genome sequencing data and thereby support disease diagnosis.

Published
2023
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233. Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia

Author

Narimasa Katsuta, Keitaro Takahashi, Yui Kurosawa, Akane Yoshikawa, Yoshihide Takeshita, Yoshihiro Uchida, Seita Yasuda, Chihiro Kakiuchi, Masanobu Ito, and Tadafumi Kato

Subjects
Lemborexant, Comorbid insomnia, Benzodiazepines, Z-drug, Specialties of internal medicine, RC581-951
Abstract

Aim: To investigate the real-world effectiveness and safety of lemborexan for treating comorbid insomnia associated with other psychiatric disorders, and whether lemborexant helps reduce the dose of benzodiazepines (BZs). Methods: This retrospective observational study was conducted on outpatients and inpatients treated by physicians of Juntendo University Hospital Mental Clinic between April 2020 and December 2021. Results: Data of 649 patients who were treated with lemborexant were eventually enrolled. About 64.5% of patients were classified as the responder group. Response rates of ≥60% were recorded for most psychiatric disorders. Upon administration of lemborexant, diazepam-equivalent dose of BZs had been significantly reduced in participants (3.7 ± 8.2 vs. 2.9 ± 7.9, p

Published
2023
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234. Pseudotumor of the skin due to Mycobacterium genavense

Author

Suguru Kurosawa, Keisuke Imafuku, Sho Nakakubo, Sumio Iwasaki, Takanori Teshima, Hideki Goto, and Hideyuki Ujiie

Subjects
Mycobacterium genavense, Mycobacterial pseudotumor, Ogawa medium, Genetic analysis, Infectious and parasitic diseases, RC109-216
Abstract

Mycobacterium genavense is a rare type of nontuberculous Mycobacterium that has been reported to cause disseminated infections in patients who are immunocompromised. Because M. genavense is slow-growing and poorly able to form colonies on Ogawa medium, genetic and molecular analyses are necessary to identify this pathogen. Nontuberculous Mycobacterium infections present with various cutaneous manifestations. Of these, rare cases have been reported to present with mycobacterial pseudotumors. However, there are no reports of M. genavense with cutaneous pseudotumors. In this paper, we report a case of a pseudotumor due to M. genavense infection that was observed only in a cutaneous lesion. The patient was taking 5 mg of prednisolone and was aware of a tumor on the right lower leg. Biopsy samples showed diffuse spindle-shaped histiocytes and various other inflammatory cell infiltrates, and Ziehl-Neelsen staining detected Mycobacterium. Because no colonies formed on the Ogawa medium, genetic testing was performed, and M. genavense was identified by DNA sequence analysis. There were no other disseminated lesions beyond the skin, including in the lungs and liver. Because the patient was immunosuppressed, in accordance with previous literature, a combination therapy of clarithromycin, ethambutol, and rifampicin for 4 months was recommended. When no growth is observed on the Ogawa medium in cases of infection, it is essential to identify the infectious pathogen by genetic analysis.

Published
2023
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235. $J/\psi$ and $\psi(2S)$ production at forward rapidity in $p$+$p$ collisions at $\sqrt{s}=510$ GeV

Author

Acharya, U. A., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Akimoto, R., Alfred, M., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E. T., Awes, T. C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Black, D., Bok, J. S., Boyle, K., Brooks, M. L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Csanád, M., Csörgő, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Ding, L., Dion, A., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Finger, Jr., M., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Gal, C., Gallus, P., Gamez, E. A., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gu, Y., Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Han, S. Y., Hanks, J., Hasegawa, S., Haseler, T. O. S., He, X., Hemmick, T. K., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Huang, J., Huang, S., Ikeda, Y., Imai, K., Imazu, Y., Inaba, M., Iordanova, A., Isenhower, D., Ishimaru, S., Ivanishchev, D., Jacak, B. V., Jeon, S. J., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Joo, E., Joo, K. S., Jouan, D., Jumper, D. S., Kang, J. H., Kang, J. S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kihara, K., Kim, C., Kim, D. H., Kim, D. J., Kim, E. -J., Kim, H. -J., Kim, M., Kim, Y. K., Kincses, D., Kistenev, E., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Koster, J., Kotov, D., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Lebedev, A., Lee, K. B., Lee, S. H., Leitch, M. J., Leitgab, M., Leung, Y. H., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Lökös, S., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Meredith, B., Metzger, W. J., Miake, Y., Mignerey, A. C., Miller, A. J., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagamiya, S., Nagashima, K., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Nihashi, M., Niida, T., Nishitani, R., Nouicer, R., Novák, T., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, S., Pate, S. F., Patel, L., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Riveli, N., Roach, D., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Sawada, S., Scarlett, C. Y., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, X., Sun, Z., Suzuki, S., Sziklai, J., Takahara, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Torii, H., Towell, M., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vargyas, M., Velkovska, J., Virius, M., Vrba, V., Vznuzdaev, E., Wang, X. R., Wang, Z., Watanabe, D., Watanabe, Y., Watanabe, Y. S., Wei, F., Whitaker, S., Wolin, S., Wong, C. P., Woody, C. L., Wu, Y., Wysocki, M., Xia, B., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yanovich, A., Yoo, J. H., Yoon, I., Younus, I., Yu, H., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., and Zou, L.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured the differential cross section, mean transverse momentum, mean transverse momentum squared of inclusive $J/\psi$ and cross-section ratio of $\psi(2S)$ to $J/\psi$ at forward rapidity in \pp collisions at \sqrts = 510 GeV via the dimuon decay channel. Comparison is made to inclusive $J/\psi$ cross sections measured at \sqrts = 200 GeV and 2.76--13 TeV. The result is also compared to leading-order nonrelativistic QCD calculations coupled to a color-glass-condensate description of the low-$x$ gluons in the proton at low transverse momentum ($p_T$) and to next-to-leading order nonrelativistic QCD calculations for the rest of the $p_T$ range. These calculations overestimate the data at low $p_T$. While consistent with the data within uncertainties above $\approx3$ GeV/$c$, the calculations are systematically below the data. The total cross section times the branching ratio is BR $d\sigma^{J/\psi}_{pp}/dy (1.2<|y|<2.2, 0

Published
2019
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236. Transformation formulas of finite sums into continued fractions

Author

Duverney, Daniel, Kurosawa, Takeshi, and Shiokawa, Iekata

Subjects
Mathematics - Number Theory
Abstract

We state and prove three general formulas allowing to transform formal finite sums into formal continued fractions and apply them to generalize certain expansions in continued fractions given by Hone and Varona., Comment: 11 pages

Published
2019

237. Transport of impact ejecta from Mars to its moons as a means to reveal Martian history

Author

Hyodo, Ryuki, Kurosawa, Kosuke, Genda, Hidenori, Usui, Tomohiro, and Fujita, Kazuhisa

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Throughout the history of the solar system, Mars has experienced continuous asteroidal impacts. These impacts have produced impact-generated Mars ejecta, and a fraction of this debris is delivered to Earth as Martian meteorites. Another fraction of the ejecta is delivered to the moons of Mars, Phobos and Deimos. Here, we studied the amount and condition of recent delivery of impact ejecta from Mars to its moons. Using state-of-the-art numerical approaches, we report, for the first time, that materials delivered from Mars to its moons are physically and chemically different from the Martian meteorites, which are all igneous rocks with a limited range of ages. We show that Mars ejecta mixed in the regolith of its moons potentially covers all its geological eras and consists of all types of rocks, from sedimentary to igneous. A Martian moons sample-return mission will bring such materials back to Earth, and the samples will provide a wealth of "time-resolved" geochemical information about the evolution of Martian surface environments., Comment: 9 pages, 3 figures, published in Scientific Reports

Published
2019
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238. Crater-ray formation through mutual collisions of hypervelocity-impact induced ejecta particles

Author

Kadono, Toshihiko, Suzuki, Ayako I., Matsumura, Rintaro, Naka, Junta, Suetsugu, Ryo, Kurosawa, Kosuke, and Hasegawa, Sunao

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We investigate the patterns observed in ejecta curtain induced by hypervelocity impact (2-6 km/s) with a variety of the size and shape of target particles. We characterize the patterns by an angle, defined as the ratio of the characteristic length of the pattern obtained by Fourier transformation to the distance from the impact point. This angle is found to be almost the same as that obtained by the reanalysis of the patterns in the previous study at lower impact velocities (Kadono et al., 2015, Icarus 250, 215-221), which are consistent with lunar crater-ray systems. Assuming that the pattern is formed by mutual collision of particles with fluctuation velocity in excavation flow, we evaluate an angle at which the pattern growth stops and show that this angle is the same in the order of magnitude as the ratio of the fluctuation velocity and the radial velocity. This relation is confirmed in the results of experiments and numerical simulations. Finally, we discuss the dependence of the patterns on impact conditions. The experiments show no dependence of the angle on impact velocity. This indicates that the ratio between the fluctuation and radial velocity components in excavation flow does not depend on impact velocity. Moreover, the independences on particle size and particle shape suggest that the angle characterizing the structure of the patterns does not depend on cohesive force. Since cohesive forces should be related with elastic properties of particles, the structure does not depend on elastic properties, though inelastic collisions are important for the persistence and contrast of the patterns., Comment: 22 pages and 7 figures, accepted for publication in Icarus

Published
2019
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239. Enhancement of impact heating in pressure-strengthened rocks in oblique impacts

Author

Wakita, Shigeru, Genda, Hidenori, Kurosawa, Kosuke, and Davison, Thomas M

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Shock-induced metamorphism in meteorites informs us about the collisional environment and history of our solar system. Recently the importance of material strength in impact heating was reported from head-on impact simulations. Here, we perform three-dimensional oblique impact simulations, and confirm the additional heating due to material strength for oblique impacts. Despite a large difference in the peak pressure at the impact point at a given impact velocity, we find that the heated mass for an oblique impact is nearly the same as that for a head-on impact. Thus, our results differ from the previous finding that the heated mass decreases as the impact becomes more oblique, and show that the additional shear heating is more effective for oblique impacts than for head-on impacts. This also indicates that material ejected during oblique impact tends to experience lower shock pressures but higher temperatures., Comment: 14 pages, 5 figures, accepted for publication in Geophysical Research Letters

Published
2019
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248. The effectiveness of preventive group cognitive-behavioral interventions on enhancing work performance-related factors and mental health of workers: a systematic review

Author

Ihara, Yuko, Kurosawa, Takumu, Matsumoto, Tamami, and Takizawa, Ryu

Subjects
Workers -- Psychological aspects -- Health aspects, Cognitive therapy -- Evaluation, Mental health -- Care and treatment, Group counseling -- Evaluation, Psychology and mental health
Abstract

The promotion of mental health and well-being for the working population is crucial. Several studies have examined the effects of group cognitive-behavioral therapy (CBT)-based interventions on promoting employees' mental health, but whether their work performance-related factors also improved has not been studied thoroughly. This systematic review was conducted to summarize and synthesize the effectiveness and characteristics of group CBT-based interventions on improving mental health and enhancing work performance-related factors from previous studies. A systematic search of studies published until November 2019 was performed using the Cochrane Central Register of Controlled Trials, PsycINFO, CINAHL, and MEDLINE. Only ten studies investigated the impact of group CBT-based interventions on both mental health and work performance-related factors in a non-clinical working population using a randomized controlled trial study design. Studies on group CBT-based interventions such as psychosocial skills training and communication skills training were included. Eight studies showed that group CBT-based interventions improved aspects of mental health; ten studies demonstrated that group CBT-based interventions influenced some aspects of work performance-related factors. Overall, the reported effect sizes varied widely, from small to large. This review supports the idea that group CBT-based interventions in a non-clinical working population may partially influence mental health and work performance-related factors. All ten included articles were published after 2015. Additional research on this topic, such as through meta-analysis, is necessary to assess whether group CBT-based intervention is effective for supporting mental health and enhancing work performance-related factors in non-clinical working populations., Author(s): Yuko Ihara [sup.1] , Takumu Kurosawa [sup.1] , Tamami Matsumoto [sup.1] , Ryu Takizawa [sup.1] Author Affiliations: (1) grid.26999.3d, 0000 0001 2151 536X, The University of Tokyo, , 7-3-1 [...]

Published
2023
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249. A 15-Year-Old Boy with Primary Maxillary Bone Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma Relapsed with Rib Metastasis after Spontaneous Remission of a Maxillary Bone Lesion: A Case Report and Literature Review

Author

Kaito Aizawa, Fumito Yamazaki, Haruko Shima, Takumi Kurosawa, Takahiro Ishikawa, Atsuko Nakazawa, and Hiroyuki Shimada

Subjects
anaplastic large cell lymphoma, spontaneous remission, primary bone lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Anaplastic large cell lymphoma (ALCL) is a rare form of non-Hodgkin’s lymphoma (NHL) in children, accounting for 10–15% of all NHL cases. ALCL is currently classified as follows: systemic anaplastic lymphoma kinase (ALK)-positive, systemic ALK-negative, primary cutaneous, and breast implant-associated ALCL. In children, systemic ALK-positive ALCL is the most common, and patients often present with extranodal involvement. We report a rare case of systemic ALK-positive ALCL with primary bone involvement in a 15-year-old male patient. Primary bone lymphoma is most commonly observed in diffuse large B-cell lymphoma and is extremely rare in systemic ALCL. Therefore, the clinical features and prognosis of primary bone ALCL remain unclear. Our patient had spontaneous remission of primary maxillary bone ALCL after gingival scraping but relapsed 12 months later with rib metastasis. Spontaneous remission of ALCL has been reported frequently in primary cutaneous ALCL and rarely in systemic ALCL. Our case demonstrates for the first time that systemic ALCL can also present as solitary bone involvement that can spontaneously remit. Because systemic ALCL is aggressive and has a risk of relapse, as in our case, it is important to consider ALCL in the differential diagnosis of primary bone lesions and to make a precise pathological diagnosis.

Published
2023
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250. Elicitation of Inhibitory Effects for AGE-Induced Oxidative Stress in Rotator Cuff-Derived Cells by Apocynin

Author

Takahiro Furukawa, Takashi Kurosawa, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Yasuhiro Ueda, Takeshi Kataoka, Kohei Yamaura, Shintaro Mukohara, Tomoya Yoshikawa, Issei Shinohara, Tatsuo Kato, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino, Takehiko Matsushita, and Ryosuke Kuroda

Subjects
advanced glycation end-products, apocynin, oxidative stress, reactive oxygen species, rotator cuff, Biology (General), QH301-705.5
Abstract

Advanced glycation end-products (AGEs) play a critical supportive role during musculoskeletal disorders via glycosylation and oxidative stress. Though apocynin, identified as a potent and selective inhibitor of NADPH oxidase, has been reported to be involved in pathogen-induced reactive oxygen species (ROS), its role in age-related rotator cuff degeneration has not been well clarified. Therefore, this study aims to evaluate the in vitro effects of apocynin on human rotator cuff-derived cells. Twelve patients with rotator cuff tears (RCTs) participated in the study. Supraspinatus tendons from patients with RCTs were collected and cultured. After the preparation of RC-derived cells, they were divided into four groups (control group, control + apocynin group, AGEs group, AGEs + apocynin group), and gene marker expression, cell viability, and intracellular ROS production were evaluated. The gene expression of NOX, IL-6, and the receptor for AGEs (RAGE) was significantly decreased by apocynin. We also examined the effect of apocynin in vitro. The results showed that ROS induction and increasing apoptotic cells after treatment of AGEs were significantly decreased, and cell viability increased considerably. These results suggest that apocynin can effectively reduce AGE-induced oxidative stress by inhibiting NOX activation. Thus, apocynin is a potential prodrug in preventing degenerative changes of the rotor cuff.

Published
2023
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