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599 results on '"Kuroki, Hiroshi"'

237. Urodynamic Study in Lumbar Spinal Disease.

Author

Kuroki, Hiroshi, primary, Tajima, Naoya, additional, Hirakawa, Shunichi, additional, Tabe, Ryuji, additional, Kubo, Shinichiro, additional, Nishi, Shouhei, additional, Yamaguchi, Takanori, additional, and Osada, Yukio, additional

Published
1995
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242. Towards Trial Simulation of Homogeneous Behavior.

Author

Nomakuchi, Takao, Kuroki, Hiroshi, and Takahashi, Masakazu

Subjects
SIMULATION methods & models, STRATEGIC planning, BUSINESS enterprises, ASYMPTOTIC homogenization, MULTIAGENT systems, FEEDBACK control systems
Abstract

Abstract: Strategic behavior of companies in the industry is composed of two parts, homogenization and differentiation. Strategic homogeneous behavior of the company builds the stabilized industry especially. Although at the present time the simulation is still in an early concept stage, we created it by multi-agent simulation (MAS). Basic concept of the homogeneous behavior simulations is reported in order to obtain feedback from a variety of perspectives. Then, in this paper the attempt of the MAS suggests that how to mix homogeneous behavior and differentiation behavior for the competitor's strategic behavior in industry. [Copyright &y& Elsevier]

Published
2013
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243. Effects of exercise level on biomarkers in a rat knee model of osteoarthritis.

Author

Yamaguchi, Shoki, Aoyama, Tomoki, Ito, Akira, Nagai, Momoko, Iijima, Hirotaka, Zhang, Xiangkai, Tajino, Junichi, and Kuroki, Hiroshi

Subjects
OSTEOARTHRITIS, EXERCISE, BIOMARKERS, LABORATORY rats, KNEE diseases, ANTERIOR cruciate ligament, SERUM, DISEASE progression
Abstract

ABSTRACT The aim of this study was to elucidate whether the levels of serum biomarkers reflect the progression of osteoarthritis (OA) induced by different levels of exercise. Thirty-five Wistar rats subjected to anterior cruciate ligament transaction (ACLT) were divided into three groups: Control, moderate running, and intense running. Twelve rats (moderate running without ACLT) were allocated as a naive group. Running was performed on a motorized treadmill, at a speed of 18 m/min for 30 min/day (moderate and naive) or 60 min/day (intense) for 3 days per week. After 2 or 4 weeks, OA histopathology in the knees was evaluated using the Osteoarthritis Research Society International (OARSI) score, and the serum levels of cleaved collagen type II (C2C) and procollagen II C-propeptide (CPII) were analyzed. The OARSI score deteriorated in the intense running group after 2 weeks and the serum C2C/CPII ratio suggested the development of OA. At 4 weeks, the C2C/CPII ratio suggested there would be deterioration in the OARSI score but the score did not differ significantly between the moderate and intense running groups. C2C/CPII ratio had 13-25% correlation with the OARSI histological score. Thus, in rat experimental OA, the OARSI score could be partially predicted by the C2C/CPII ratio as a serum biomarker of OA. © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1026-1031, 2013 [ABSTRACT FROM AUTHOR]

Published
2013
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248. Longitudinal evaluation of cartilage after osteochondral autogenous transfer with delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC).

Author

Shirai, Takaaki, Kobayashi, Masahiko, Nakamura, Shinichiro, Arai, Ryuzo, Nishitani, Kohei, Satake, Tsuyoshi, Dahlberg, Leif E., Kuroki, Hiroshi, Nakagawa, Yasuaki, Okada, Tomohisa, Togashi, Kaori, and Nakamura, Takashi

Subjects
GADOLINIUM, MAGNETIC resonance imaging, CARTILAGE, GLYCOSAMINOGLYCANS, ORTHOPEDICS
Abstract

The aim was to use repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to estimate glycosaminoglycan (GAG) content in reparative cartilage after osteochondral autogenous transfer (OAT). The study group comprised 7 knees of 7 patients that were examined three times by dGEMRIC, at 3, 6, and 12 months using a 1.5 Tesla MRI system in both OAT operated and nonoperated condyles at 90 min after the injection. The gadolinium diethylene triamine pentaacetic acid (Gd-DTPA)2− containing contrast medium (0.2 mmols/kg) was injected intravenously. The mean T1 values of the plug cartilage at 3, 6, and 12 months after OAT was 230 ± 40, 213 ± 31, and 230 ± 23 ms (mean ± SD), respectively. There were differences between the plug and control cartilage at 3 ( p < 0.01) and 12 ( p < 0.05) months after OAT, but not at 6 months ( p = 0.089). No T1 changes were detected between the plug cartilage at the different time points after OAT. The fact that the GAG content of the OAT plugs were maintained for 12-month study period suggest that no major deterioration of load-bearing properties occurs in the cartilage after the OAT. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:221-225, 2012 [ABSTRACT FROM AUTHOR]

Published
2012
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249. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis.

Author

Shirai, Takaaki, Kobayashi, Masahiko, Nishitani, Kohei, Satake, Tsuyoshi, Kuroki, Hiroshi, Nakagawa, Yasuaki, and Nakamura, Takashi

Subjects
DIPHOSPHONATES, DRUG efficacy, OSTEOARTHRITIS treatment, ANTERIOR cruciate ligament surgery, RABBITS
Abstract

The aim of this study was to determine how alendronate (ALN) alters cartilage degeneration and periarticular bone quality in a rabbit anterior cruciate ligament transection (ACLT) model of osteoarthritis (OA). Thirty rabbits underwent an ACLT on the left knee and a sham operation on the right knee. Fifteen rabbits received weekly subcutaneous injections of ALN (0.14 mg/kg) and 15 rabbits (the control [cont] group) received saline. Animal knees were divided into four groups: cont/sham, cont/ACLT, ALN/sham, and ALN/ACLT. Histological, radiological, and immunohistochemical indices were evaluated for each group. Bone volume ratios by micro-computed tomography showed that ALN prevented periarticular bone loss. Histologically, the cont/ACLT group had significantly worse cartilage damage than the cont/sham group 12 weeks after the surgery. However, the ALN/ACLT group had mild cartilage degeneration compared with that of the ALN/sham group. Immunohistochemical analysis showed that ALN suppressed the expression of matrix metalloproteinase-13, interleukin-1β, type-X collagen, vascular endothelial growth factor, and receptor activator of nuclear factor κB ligand in OA cartilage. ALN had a chondroprotective effect in an experimental rabbit model of OA. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 1572-1577, 2011 [ABSTRACT FROM AUTHOR]

Published
2011
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250. Ultrasound properties of articular cartilage immediately after osteochondral grafting surgery: in cases of traumatic cartilage lesions and osteonecrosis.

Author

Kuroki, Hiroshi, Nakagawa, Yasuaki, Mori, Koji, Kobayashi, Masahiko, Nakamura, Shinichiro, Nishitani, Kohei, Shirai, Takaaki, and Nakamura, Takashi

Subjects
*DIAGNOSTIC imaging, *OSTEONECROSIS, *BONE grafting, *CARTILAGE tumors, *OPERATIVE surgery, *DIAGNOSTIC ultrasonic imaging
Abstract

Although osteochondral grafting surgery is believed to replace damaged cartilage with healthy-looking normal cartilage, no study focuses on ultrasound quantification of those cartilage immediately after the surgery. It is unknown whether the ultrasound properties of damaged cartilage from trauma or osteonecrosis are same with each other. We have examined ultrasound properties of damaged cartilage, adjacent intact cartilage and plug cartilage during osteochondral grafting surgery for 15 knees of 15 patients, mean age of 43.4 (range, 14–61) years. Results showed that signal intensities of ultrasound (a measure of superficial cartilage integrity) of intact cartilage, damaged cartilage, and plug cartilage were 1.91 (arbitrary unit), 0.40, and 2.13, respectively, in 11 knees of 11 patients of traumatic cartilage lesions. Interval between signals of ultrasound (a parameter related to thickness) were 2.79 (μs), 1.90, and 2.85, respectively. The signal intensity and the interval between signals of plug cartilage were 533% ( P < 0.01) and 150% ( P < 0.01) of damaged cartilage, respectively. In four knees of four patients of osteonecrosis, the signal intensities of intact cartilage, damaged cartilage, and plug cartilage were 1.25, 0.30, and 1.39, respectively. The interval between signals were 2.36, 2.00, and 2.69, respectively. The signal intensity and the interval between signals of plug cartilage were 463% ( P < 0.01) and 135% ( P < 0.05) of damaged cartilage. We conclude that ultrasound properties of the damaged cartilage from trauma or osteonecrosis did not differ a lot especially in the late stages of osteonecrosis and that the osteochondral grafting surgery replaced the damaged cartilage with plug cartilage that had greater superficial cartilage integrity and greater thickness parameter immediately after the surgery. Long-term effect of the osteochondral grafting surgery should be verified in further study. [ABSTRACT FROM AUTHOR]

Published
2009
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