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981 results on '"Kuo, Ho-Chang"'

215. Validity of Visual and Auditory Attention Tests for Detecting ADHD.

Author

Wang, Liang-Jen, Lee, Sheng-Yu, Tsai, Ching-Shu, Lee, Min-Jing, Chou, Miao-Chun, Kuo, Ho-Chang, and Chou, Wen-Jiun

Subjects
ATTENTION-deficit hyperactivity disorder, AUDITORY selective attention, NEUROPSYCHOLOGICAL tests, RESPONSE styles (Examinations), NURSING assessment
Abstract

Objective: This investigation examines the discriminative validity of visual and auditory attention tests for differentiating patients with ADHD from healthy control participants. Method: A total of 107 ADHD patients and 58 healthy control participants were recruited. Visual and auditory attention profiles were obtained using the Conners' Continuous Performance Test 3rd Edition (CPT3) and Conners' Continuous Auditory Test of Attention (CATA), respectively. Results: We found that ADHD patients underperformed healthy controls on all CPT3 and CATA indexes, except Response Style and Hit Reaction Time. The CPT3, CATA, and CPT3 plus CATA all significantly differentiate ADHD patients and controls. CPT3 plus CATA had a greater sensitivity (82.6%), specificity (76%), positive predictive value (88.8%), negative predictive value (65.5%), and overall correct classification rate (80.6%) than CPT3 or CATA alone. Conclusion: Neuropsychological tests CPT3 and CATA provide objective information about cases of ADHD and should be used routinely for clinical assessment. [ABSTRACT FROM AUTHOR]

Published
2021
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221. Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease.

Author

Hsu, Yu‐Wen, Lu, Hsing‐Fang, Chou, Wan‐Hsuan, Kuo, Ho‐Chang, Chang, Wei‐Chiao, and Atanaskovic‐Markovic, Marina

Subjects
MUCOCUTANEOUS lymph node syndrome, GENETIC polymorphisms, SINGLE nucleotide polymorphisms, CD54 antigen
Abstract

Background: Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD. Methods: A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping. Results: Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility. Conclusions: This study indicated the close correlation between IP10 and the risk of Kawasaki disease. [ABSTRACT FROM AUTHOR]

Published
2021
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236. Increase risk of allergic diseases in patients with ankylosing spondylitis

Author

Chang, Wei-Pin, Kuo, Chun-Nan, Kuo, Li-Na, Wang, Yao-Tung, Perng, Wuu-Tsun, Kuo, Ho-Chang, and Wei, James Cheng-Chung

Subjects
Adult, Male, allergic rhinitis, Time Factors, atopic dermatitis, Adolescent, Taiwan, Infant, Observational Study, asthma, Middle Aged, Rhinitis, Allergic, Risk Assessment, Dermatitis, Atopic, allergic disease, population-based study, Child, Preschool, ankylosing spondylitis, Humans, Female, Spondylitis, Ankylosing, Child, Research Article, Follow-Up Studies
Abstract

Th2 and Th17 cells are both associated with developing ankylosing spondylitis (AS) and asthma. Th2 cells are also associated with allergic rhinitis and atopic dermatitis (AD). The prevalence of such allergic diseases in AS patients is unknown. In this study, we intended to study the risk of allergic diseases in a 10-year follow-up population of newly diagnosed patients with AS. We used a nationwide 10-year population-based database retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan. The study cohort comprised 857 patients with AS who had at least 1 claim of inpatient admission or at least 2 claims of ambulatory visit. The comparison cohort consisted of 4285 randomly selected subjects matched with AS group at a ratio of 5:1. We used Cox proportional-hazards regression to determine the 10-year disease-free survival rates after adjusting for potentially confounding factors. The AS patients had a 1.31 times greater risk of developing asthma within 10 years of diagnosis when compared with non-AS age- and sex-matched subjects, after adjusting for other risk factors (95% confidence interval = 1.00–1.75). But the difference was not significantly different. The AS patients also had a 1.46 times and a 1.22 times greater risk of developing allergic rhinitis and AD significantly. AS patients also had a lower allergic disease-free survival rate compared to non-AS group. Our results showed that patients with AS had a higher risk of developing allergic diseases later in life.

Published
2016

237. General anesthesia exposure in early life reduces the risk of allergic diseases

Author

Kuo, Ho-Chang, Yang, Ya-Ling, Ho, Shu-Chen, Guo, Mindy Ming-Huey, Jiang, Jyun-Hong, and Huang, Ying-Hsien

Subjects
Male, Taiwan, Observational Study, Infant, Anesthesia, General, general anesthesia, Rhinitis, Allergic, Asthma, Dermatitis, Atopic, allergic disease, children, Risk Factors, cohort study, Humans, Female, Research Article, Retrospective Studies
Abstract

General anesthesia (GA) has been used for second line treatment strategy for status asthmaticus in pediatric patients. The association between GA in children and risk of followed-up allergic diseases is unclear. This study aims to assess the risk of allergic diseases after GA in children. We did a nationwide retrospective cohort study by analyzing data from the National Health Insurance Research Database (NHIRD) in Taiwan. The subsequent risks for allergic diseases, including asthma (ICD-9: 493.X), allergic rhinitis (AR; ICD-9 CM code 477.X), and atopic dermatitis (AD; ICD-9-CM code 691.X), were compared between exposure to GA and none before 1 year of age throughout the follow-up period using the Cox proportional hazards model. Insurance claims data for 32,742 children younger than 1 year old from all insured children in the NHIRD. Of those, 2358 subjects were exposed to GA; 414 and 1944 children exposed to mask and intubation ventilation, respectively, served as the study cohort, whereas the remaining 30,384 children made up the comparison cohort. Children in the GA group were at a lower risk of developing asthma, AR and AD, with adjusted hazard ratios of 0.67 (0.62–0.72, 95%CI), 0.72 (0.68–0.77, 95%CI), 0.60 (0.56–0.64, 95%CI), respectively. Children who were exposed to GA in early life before 1 year of age had reduced risk of subsequently developing allergic diseases such as asthma, AD, and AR, when compared with general population.

Published
2016

242. Prediction for Intravenous Immunoglobulin Resistance by Using Weighted Genetic Risk Score Identified From Genome-Wide Association Study in Kawasaki Disease

Author

Kuo, Ho-Chang, primary, Wong, Henry Sung-Ching, additional, Chang, Wei-Pin, additional, Chen, Ben-Kuen, additional, Wu, Mei-Shin, additional, Yang, Kuender D., additional, Hsieh, Kai-Sheng, additional, Hsu, Yu-Wen, additional, Liu, Shih-Feng, additional, Liu, Xiao, additional, and Chang, Wei-Chiao, additional

Published
2017
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246. Correlation ofHAMPgene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease

Author

Huang, Ying-Hsien, primary, Yang, Kuender D., additional, Hsu, Yu-Wen, additional, Lu, Hsing-Fang, additional, Wong, Henry Sung-Ching, additional, Yu, Hong-Ren, additional, Kuo, Hsing-Chun, additional, Huang, Fu-Chen, additional, Lo, Mao-Hung, additional, Hsieh, Kai-Sheng, additional, Chen, Su-Fen, additional, Chang, Wei-Chiao, additional, and Kuo, Ho-Chang, additional

Published
2017
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247. l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes

Author

Yu, Hong-Ren, primary, Tsai, Ching-Chang, additional, Chang, Ling-Sai, additional, Huang, Hsin-Chun, additional, Cheng, Hsin-Hsin, additional, Wang, Jiu-Yao, additional, Sheen, Jiunn-Ming, additional, Kuo, Ho-Chang, additional, Hsieh, Kai-Sheng, additional, Huang, Ying-Hsien, additional, Yang, Kuender D., additional, and Hsu, Te-Yao, additional

Published
2017
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