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797 results on '"Kuchibhatla, Maragatha"'

203. Depressive Symptoms and Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease

Author

Boyle, Stephen H., primary, Samad, Zainab, additional, Becker, Richard C., additional, Williams, Redford, additional, Kuhn, Cynthia, additional, Ortel, Thomas L., additional, Kuchibhatla, Maragatha, additional, Prybol, Kevin, additional, Rogers, Joseph, additional, O’Connor, Christopher, additional, Velazquez, Eric J., additional, and Jiang, Wei, additional

Published
2013
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205. Prevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease

Author

Jiang, Wei, primary, Samad, Zainab, additional, Boyle, Stephen, additional, Becker, Richard C., additional, Williams, Redford, additional, Kuhn, Cynthia, additional, Ortel, Thomas L., additional, Rogers, Joseph, additional, Kuchibhatla, Maragatha, additional, O'Connor, Christopher, additional, and Velazquez, Eric J., additional

Published
2013
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212. Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies

Author

Lee, Grace M., Joglekar, Manali, Kuchibhatla, Maragatha, Khandelwal, Sanjay, Qi, Rui, Rauova, Lubica, and Arepally, Gowthami M.

Abstract

Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery. To understand the biologic significance of anti-PRT/heparin antibodies, we developed a murine monoclonal antibody (ADA) specific for PRT/heparin complexes and compared it to patient-derived anti-PRT/heparin antibodies, as well as comparing polyclonal and monoclonal antibodies with anti–platelet factor 4 (PF4)/heparin. Using monoclonal antibodies and polyclonal patient-derived antibodies, we show distinctive binding patterns of anti-PRT/heparin antibodies as compared with PF4/heparin antibodies. Whereas heparin-induced thrombocytopenia (HIT) antibody binding to PF4/heparin is inhibited by relatively low doses of heparin (0-1 U/mL), anti-PRT/heparin antibodies, including ADA, retain binding to PRT/heparin over a broad range of heparin concentrations (0-50 U/mL). Unlike PF4/heparin antibodies, which recognize PF4 complexed to purified or cell-associated glycosaminoglycans (GAGs), anti-PRT/heparin antibodies show variable binding to cell-associated GAGs. Further, binding of anti-PRT/heparin antibodies to PRT/dextran complexes correlates closely with the ability of antibodies to bind to cell-surface PRT. These findings suggest that antibody binding to PRT/dextran may identify a subset of clinically relevant anti-PRT/heparin antibodies that can bind to cell-surface GAGs. Together, these findings show important serologic differences between HIT and anti-PRT/heparin antibodies, which may account for the variability in disease expression of the two classes of heparin-dependent antibodies.

Published
2017
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225. Marital Status and Prognosis of Patients with Heart Failure

Author

O'Connor, Erin, primary, Jiang, Wei, additional, Kuchibhatla, Maragatha, additional, Clary, Greg, additional, Cuffe, Michael, additional, Christopher, Eric, additional, Alexander, Jude, additional, Fiuzat, Mona, additional, O'Connor, Christopher, additional, and Krishnan, Ranga, additional

Published
2009
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230. Safety and Efficacy of Sertraline plus Nurse Facilitated Supportive Intervention (NFSI) versus Placebo plus Nurse Facilitated Supportive Intervention for Depression in Patients with CHF (SADHART-CHF) (10/6/08)

Author

O'Connor, Christopher M., primary, Jiang, Wei, additional, Silva, Susan G., additional, Kuchibhatla, Maragatha, additional, Cuffe, Michael S., additional, Callwood, Dwayne D., additional, Zakhary, Bosh, additional, Henke, Elizabeth, additional, Arias, Rebekka M., additional, and Krishnan, Ranga, additional

Published
2008
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238. Time to Antivenom Administration Is Not Associated With Total Antivenom Dose Administered in a Copperhead-predominant Snakebite Population.

Author

Gerardo, Charles J., Scott Evans, C., Kuchibhatla, Maragatha, Mando‐Vandrick, Jennifer, Drake May Yen, Weiying G., Kopec, Kathryn, Lavonas, Eric J., and Bird, Steven

Subjects
THROMBOCYTOPENIA, ANTICOAGULANTS, ANTIVENINS, BLOOD coagulation, BLOOD coagulation disorders, DEMOGRAPHY, DOSAGE forms of drugs, EMERGENCY medicine, GENETIC techniques, HEMORRHAGE, HOSPITAL admission & discharge, LEG, MEDICAL care, EVALUATION of medical care, PATIENTS, REPTILES, SERIAL publications, SNAKEBITES, RETROSPECTIVE studies, PATIENT selection, TERTIARY care, DIAGNOSIS
Abstract

Objectives To prevent unnecessary antivenom administration in crotaline snakebite, observation for progression is recommended for the patient with minor envenomation whose condition is stable and not progressing. The objective of this study was to determine the association between the time from bite to initial antivenom administration (Time AV) and the total amount of antivenom administered (Total AV) and to determine what proportion of patients did not have progression of the envenomation syndrome and did not receive antivenom. Methods This was a retrospective chart review of patients presenting with crotaline snakebite within 24 hours from 2009 through 2012. Blinded dual-chart abstraction and strict data point definitions were used. Spearman correlation was used to determine the association between Time AV and Total AV. A general linear model was used to examine this association using Time AV categorized to early and late administration, adjusted for likely confounders. Confounders included age, extremity involved, initial severity, and year of envenomation. Results Ninety-five eligible patients were analyzed with 45 (47%) males and a mean (± SD) age of 36.5 (±21.1) years. Eighty-five (89%) received antivenom, with a median Time AV of 3.3 hours (interquartile range [ IQR] = 2.5 to 5.2 hours). The median Total AV was 10 vials ( IQR = 6 to 14 vials). The univariate analysis showed a small but statistically significant decrease in Total AV given to patients treated greater than 6 hours from bite (r = -0.26, p = 0.015). The multivariate analysis resulted in no significant relation between early or late Time AV and Total AV (p = 0.10) after adjustment for confounders. Most minimal envenomation syndromes (80%, or 41 of 51) progressed to moderate grade envenomations. Conclusions Time AV was not associated with Total AV when adjusted for likely confounders and supports current recommendations to observe for progression in minor envenomation. The majority of envenomations progressed, resulting in only a small proportion of patients not eventually receiving antivenom. The authors recommend observation in an environment where the patient can be adequately reassessed for progression of the envenomation. [ABSTRACT FROM AUTHOR]

Published
2015
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244. Prognostic Value of Anxiety and Depression in Patients With Chronic Heart Failure

Author

Jiang, Wei, primary, Kuchibhatla, Maragatha, additional, Cuffe, Michael S., additional, Christopher, Eric J., additional, Alexander, Jude D., additional, Clary, Greg L., additional, Blazing, Michael A., additional, Gaulden, Laura H., additional, Califf, Robert M., additional, Krishnan, Ranga R., additional, and O’Connor, Christopher M., additional

Published
2004
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250. Pre-clinical Cognitive Phenotypes for Alzheimer Disease: A Latent Profile Approach.

Author

Hayden, Kathleen M., Kuchibhatla, Maragatha, Romero, Heather R., Plassman, Brenda L., Burke, James R., Browndyke, Jeffrey N., and Welsh-Bohmer, Kathleen A.

Abstract

The article makes use of the data from the National Alzheimer Disease Coordinating Center (NACC) to identify subtypes of cognitively normal adults with various cognition patterns, which may imply later Alzheimer disease (AD) or dementia onset. Findings discussed include the results of the exploratory factor analysis (EFA) performed on the first half of the sample, the latent profile analysis (LPA) done using the CFA factor scores, baseline age and sex, and the predictors of profile membership.

Published
2014
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