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4,817 results on '"Kovalenko, S."'

207. Observation of Collider Muon Neutrinos with the SND@LHC Experiment.

Author

Albanese R, Alexandrov A, Alicante F, Anokhina A, Asada T, Battilana C, Bay A, Betancourt C, Biswas R, Blanco Castro A, Bogomilov M, Bonacorsi D, Bonivento WM, Bordalo P, Boyarsky A, Buontempo S, Campanelli M, Camporesi T, Canale V, Castro A, Centanni D, Cerutti F, Chernyavskiy M, Choi KY, Cholak S, Cindolo F, Climescu M, Conaboy AP, Dallavalle GM, Davino D, de Bryas PT, De Lellis G, De Magistris M, De Roeck A, De Rújula A, De Serio M, De Simone D, Di Crescenzo A, Donà R, Durhan O, Fabbri F, Fedotovs F, Ferrillo M, Ferro-Luzzi M, Fini RA, Fiorillo A, Fresa R, Funk W, Garay Walls FM, Golovatiuk A, Golutvin A, Graverini E, Guler AM, Guliaeva V, Haefeli GJ, Helo Herrera JC, van Herwijnen E, Iengo P, Ilieva S, Infantino A, Iuliano A, Jacobsson R, Kamiscioglu C, Kauniskangas AM, Khalikov E, Kim SH, Kim YG, Klioutchnikov G, Komatsu M, Konovalova N, Kovalenko S, Kuleshov S, Lacker HM, Lantwin O, Lasagni Manghi F, Lauria A, Lee KY, Lee KS, Lo Meo S, Loschiavo VP, Marcellini S, Margiotta A, Mascellani A, Miano A, Mikulenko A, Montesi MC, Navarria FL, Ogawa S, Okateva N, Ovchynnikov M, Paggi G, Park BD, Pastore A, Perrotta A, Podgrudkov D, Polukhina N, Prota A, Quercia A, Ramos S, Reghunath A, Roganova T, Ronchetti F, Rovelli T, Ruchayskiy O, Ruf T, Sabate Gilarte M, Samoilov M, Scalera V, Schneider O, Sekhniaidze G, Serra N, Shaposhnikov M, Shevchenko V, Shchedrina T, Shchutska L, Shibuya H, Simone S, Siroli GP, Sirri G, Soares G, Soto Sandoval OJ, Spurio M, Starkov N, Timiryasov I, Tioukov V, Tramontano F, Trippl C, Ursov E, Ustyuzhanin A, Vankova-Kirilova G, Verguilov V, Viegas Guerreiro Leonardo N, Vilela C, Visone C, Wanke R, Yaman E, Yazici C, Yoon CS, Zaffaroni E, and Zamora Saa J

Abstract

We report the direct observation of muon neutrino interactions with the SND@LHC detector at the Large Hadron Collider. A dataset of proton-proton collisions at sqrt[s]=13.6  TeV collected by SND@LHC in 2022 is used, corresponding to an integrated luminosity of 36.8  fb^{-1}. The search is based on information from the active electronic components of the SND@LHC detector, which covers the pseudorapidity region of 7.2<η<8.4, inaccessible to the other experiments at the collider. Muon neutrino candidates are identified through their charged-current interaction topology, with a track propagating through the entire length of the muon detector. After selection cuts, 8 ν&#95;{μ} interaction candidate events remain with an estimated background of 0.086 events, yielding a significance of about 7 standard deviations for the observed ν&#95;{μ} signal.

Published
2023
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208. OperatorEYEVP: Operator Dataset for Fatigue Detection Based on Eye Movements, Heart Rate Data, and Video Information.

Author

Kovalenko S, Mamonov A, Kuznetsov V, Bulygin A, Shoshina I, Brak I, and Kashevnik A

Subjects
Humans, Heart Rate, Videotape Recording, Reaction Time, Eye Movements, Head Movements physiology
Abstract

Detection of fatigue is extremely important in the development of different kinds of preventive systems (such as driver monitoring or operator monitoring for accident prevention). The presence of fatigue for this task should be determined with physiological and objective behavioral indicators. To develop an effective model of fatigue detection, it is important to record a dataset with people in a state of fatigue as well as in a normal state. We carried out data collection using an eye tracker, a video camera, a stage camera, and a heart rate monitor to record a different kind of signal to analyze them. In our proposed dataset, 10 participants took part in the experiment and recorded data 3 times a day for 8 days. They performed different types of activity (choice reaction time, reading, correction test Landolt rings, playing Tetris), imitating everyday tasks. Our dataset is useful for studying fatigue and finding indicators of its manifestation. We have analyzed datasets that have public access to find the best for this task. Each of them contains data of eye movements and other types of data. We evaluated each of them to determine their suitability for fatigue studies, but none of them fully fit the fatigue detection task. We evaluated the recorded dataset by calculating the correspondences between eye-tracking data and CRT (choice reaction time) that show the presence of fatigue.

Published
2023
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209. 5,6-Dihydrotetrazolo[1,5-c]quinazolines: Toxicity prediction, synthesis, antimicrobial activity, molecular docking, and perspectives.

Author

Antypenko L, Antypenko O, Karnaukh I, Rebets O, Kovalenko S, and Arisawa M

Subjects
Molecular Docking Simulation, Structure-Activity Relationship, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Microbial Sensitivity Tests, Molecular Structure, Antifungal Agents pharmacology, Quinazolines pharmacology, Quinazolines chemistry, Anti-Infective Agents pharmacology, Anti-Infective Agents chemistry
Abstract

Antimicrobial resistance is a never-ending challenge, which should be considered seriously, especially when using unprescribed "over-the-counter" drugs. The synthesis and investigation of novel biologically active substances is among the directions to overcome this problem. Hence, 18 novel 5,6-dihydrotetrazolo[1,5-c]quinazolines were synthesized, their identity, purity, and structure were elucidated by elemental analysis, IR, LC-MS, 1 Н, and 13 C NMR spectra. According to the computational estimation, 15 substances were found to be of toxicity Class V, two of Class IV, and only one of Class II. The in vitro serial dilution method of antimicrobial screening against Escherichia coli, Staphylococcus aureus, Klebsiella aerogenes, Pseudomonas aeruginosa, and Candida albicans determined b3, c1, c6, and c10 as the "lead-compounds" for further modifications to increase the level of activity. Substance b3 demonstrated antibacterial activity that can be related to the calculated high affinity toward all studied proteins: 50S ribosomal protein L19 (PDB ID: 6WQN), sterol 14-alpha demethylase (PDB ID: 5TZ1), and ras-related protein Rab-9A (PDB ID: 1WMS). The structure-activity and structure-target affinity relationships are discussed. The targets for further investigations and the anatomical therapeutic chemical codes of drug similarity are predicted., (© 2023 Deutsche Pharmazeutische Gesellschaft.)

Published
2023
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212. SYNTHESIS OF 6-CHLORO(DICHLORO-, TRICHLORO-)-METHYL-3-R-6,7-DIHYDRO-2H-[1,2,4]TRIAZINO[2,3-C]QUINAZOLIN-2-ONES AND THEIR MODIFICATION IN REACTIONS WITH NUCLEOPHILIC AND NON-NUCLEOPHILIC BASES.

Author

Grytsak, O. A., Moskalenko, O. S., Voskoboinik, O. Yu., and Kovalenko, S. I.

Subjects
NUCLEOPHILIC catalysis, CHLORAL, MORPHOLINE, CHLOROMETHYL group, ETHYLENE glycols
Abstract

The synthesis of 6-chloro-(dichloro-, trichloro)methyl-3-R-6,7-dihydro-2H-[1.2.4] triazino[2,3-c]quinazolin-2-ones and their modification under the action of nucleophilic and/or basic reagents are described in this article. It was shown that 6-chloro-(dichloro-, trichloro)methyl-3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones can be prepared by cyclocondensation of 3-(aminophenyl)-6-R-1,2;4-triazine-5(2W)-ones with chloro-(dichloro-)acetaldehyde or chloral hydrate. The reactivity of the synthesized compounds toward nucleophilic base morpholine and non-nucleophilic base diisopropylethylamine (DIPEA) under different conditions was studied. It was shown that the prepared compounds under the action of morpholine and/or DIPEA can be converted into the products of substitution, elimination or elimination followed by isomerization and substitution. Refluxing of 6-(chloromethyl)-3-R-6,7-dihydro-2 H-[1.2.4] triazino[2,3-c]quinazoline-2-ones with equimolar quantity of morpholine and 10% excess of DIPEA in ethylene glycol monoethyl ether (EGEE) yielded the products on N-alkylation. 6-(Morpholinomethyl)-3-R-2 H-[1,2,4]triazino[2,3-c]quinazoline-2-ones were obtained by heating of 6-dichloromethyl-3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones with five-fold excess of morpholine in EGEE. Reaction of 3-R-6-(trichloromethyl)-6,7-dihydro-2 H-[1,2,4]triazino[2,3-c]quinazolin-2-ones with three-fold excess of DIPEA in EGEE yielded 3-R-2#-[1,2,4]triazino[2,3-c]quinazoline-2-ones. The physicochemical and spectral characteristics of the prepared compounds were determined and discussed. [ABSTRACT FROM AUTHOR]

Published
2021
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213. The search for potential inhibitors of protein kinase Pim-1 among new amides of 1,2,4-triazolo[4,3-a]pyridine-3-metanamin with the 1,2,4-oxadiazol cycle in position 7 and 8

Author

Karpina, V. R., Kovalenko, S. M., Zaremba, O. V., Silin, O. V., Ivanov, V. V., Kovalenko, S. S., Langer, T., Karpina, V. R., Kovalenko, S. M., Zaremba, O. V., Silin, O. V., Ivanov, V. V., Kovalenko, S. S., and Langer, T.

Abstract

The Pim-1 enzyme from the serine/threonine protein kinase family is a likely target for the targeted therapy of tumors of hematopoietic and lymphoid tissues. Triazolopyridine is an universal scaffold upon which international scientific programs have been launched to develop potential anticancer agents.Aim. To create a pharmacophore model to find new potential Pim-1 inhibitors; conduct a virtual screening of a simulated base of new 1,2,4-triazolo[4,3-a]pyridine derivatives; develop a method for the synthesis of 1,2,4-triazolo[4,3-a]pyridine-3-methanamines with the 1,2,4-isoxadiazole cycle.Results and discussion. In this study, a ligand-based pharmacophore model for Pim-1 inhibitors was constructed and validated. A virtual screening of the library with 912 compounds resulted in a hit list of 175 compounds. For the synthesis, 15 compounds were selected with the highest pharmacophore-fit score. 15 compounds were synthesized as potential inhibitors of Pim-1 kinase.Experimental part. The synthetic approach has been developed, and systematic series of new amides of (7-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine and (8-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methanamine have been synthesized.Conclusions. The compounds obtained are potential inhibitors of Pim-1 kinase. Further studies will focus on the determination of the antitumor activity of the compounds synthesized by in vitro and in vivo methods., Фермент Pim-1 из семейства серин/треонин протеинкиназы является вероятной мишенью для таргетной терапии опухолей кроветворной и лимфоидной тканей. Триазолопиридины – это универсальный скаффолд, на базе которого проводятся международные научные программы по разработке потенциальных противораковых средств.Цель. Создать фармакофорную модель для поиска новых потенциальных ингибиторов Pim-1. Провести виртуальный скрининг смоделированной базы новых производных 1,2,4-триазоло[4,3-а]пиридинов и разработать метод синтеза амидов 1,2,4-триазоло[4,3-а]пиридин-3-метанамина, содержащих 1,2,4-изоксадиазольный цикл.Результаты и обсуждение. Создана и валидирована фармакофорная модель ингибиторов Pim-1 на основе известной информации о структурах активных лигандов. Проведен виртуальный скрининг библиотеки из 912 соединений, результатом которого стал список хитов из 175 соединений. Для синтеза были отобраны 15 соединений с наиболее высокой фармакофорной оценкой. Синтезированы 15 соединений, являющихся потенциальными ингибиторами киназы Pim-1.Экспериментальная часть. Разработана схема, методики синтеза и синтезированы систематические ряды новых амидов (7-(1,2,4-оксадиазол-5-ил)-[1,2,4]триазоло[4,3-а]пиридин-3-ил)метанамина и (8-(1,2,4-оксадиазол-5-ил)-[1,2,4]триазоло[4,3-а]пиридин-3-ил)метанамина.Выводы. Полученные соединения являются потенциальными ингибиторами киназы Pim-1. Дальнейшие исследования будут направлены на выявление противоопухолевой активности синтезированных соединений методами in vitro и in vivo., Фермент Pim-1 з сімейства серин/треонін протеїнкіназ є ймовірною мішенню для таргетної терапії пухлин кровотворної та лімфоїдної тканини. Триазолопіридини – це універсальний скафолд, на базі якого реалізуються міжнародні наукові програми з розробки потенційних протиракових засобів.Мета. Створити фармакофорну модель для пошуку нових потенційних інгібіторів Pim-1. Провести віртуальний скринінг змодельованої бази нових похідних 1,2,4-триазоло[4,3-а]піридину та розробити метод синтезу амідів 1,2,4-триазоло[4,3-а]піридин-3-метанаміну, що містять 1,2,4-ізоксадіазольний цикл.Результати та обговорення. Створено та валідовано фармакофорну модель інгібіторів Pim-1 на основі відомої інформації про структури активних лігандів. Проведено віртуальний скринінг бібліотеки з 912 сполук, результатом якого став список хітів із 175 сполук. Для синтезу було відібрано 15 сполук з найвищою фармакофорною оцінкою. Синтезовано 15 сполук, що є потенційними інгібіторами кінази Pim-1.Експериментальна частина. Розроблено схему, методики синтезу та синтезовано систематичні ряди нових амідів (7-(1,2,4-оксадіазол-5-іл)-[1,2,4]триазоло[4,3-а]піридин-3-іл)метанаміну та (8-(1,2,4-оксадіазол-5-іл)-[1,2,4]триазоло[4,3-а]піридин-3-іл)метанаміну.Висновки. Отримані сполуки є потенційними інгібіторами кінази Pim-1. Подальші дослідження будуть спрямовані на виявлення протипухлинної активності синтезованих сполук методами in vitro та in vivo.

Published
2019

214. The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazol cycle in positions 6, 7 and 8

Author

Karpina, V. R., Kovalenko, S. S., Kovalenko, S. M., Zaremba, O. V., Silin, O. V., Langer, T., Karpina, V. R., Kovalenko, S. S., Kovalenko, S. M., Zaremba, O. V., Silin, O. V., and Langer, T.

Abstract

Fused heterocyclic 1,2,4-triazoles have provided much attention due to variety of their interesting biological properties.Aim. To develop the method for the synthesis of novel 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and conduct the biological assessment of the compounds synthesized.Results and discussion. A diverse set of acetamides newly synthesized consists of 32 analogs bearing an 1,2,4-oxadiazole cycle in positions 6, 7 and 8. A convenient scheme of the synthesis starts from commercially available 2-chloropyridine-3-, 2-chloropyridine-4-, 2-chloropyridine-5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[3-R1-1,2,4-oxadiazol-5-yl]pyridines, then follows the reaction of hydrazinolysis with an excess of hydrazine hydrate. The process continues via the ester formation with the pyridine ring closure, then the amide formations of the end products are obtained by hydrolysis into acetic acid.Experimental part. A series of new 2-[6-(1,2,4-oxadiazol-5-yl)-, 2-[7-(1,2,4-oxadiazol-5-yl)-, 2-[8-(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields, and their structures were proven by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacological activity were also conducted.Conclusions. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives., Конденсированные гетероциклические 1,2,4-триазолы привлекают большое внимание разнообразием интересных биологических свойств.Цель работы. Разработать метод синтеза новых 2-[(1,2,4-оксадиазол-5-ил)- [1,2,4]триазоло[4,3-a]пиридин-3-ил]ацетамидов и провести биологическую оценку синтезированных соединений.Результаты и их обсуждение. Синтезирован ряд новых производных ацетамидов, который состоит из 32 аналогов, содержащих 1,2,4-оксадиазольный цикл в 6, 7 и 8 положениях. Удобная схема синтеза начинается с коммерчески доступных 2-хлорпиридин-3, 2-хлорпиридин-4, 2-хлорпиридин-5-карбоновых кислот с амидоксимами с образованием соответствующих 2-хлор-[3-R1-1,2,4-оксадиазол-5-ил]пиридинов, после чего следует реакция гидразинолиза с избытком гидразин гидрата. Процесс продолжается путем образования эфира с закрытием пиридинового кольца, затем через гидролиз к уксусной кислоте мы получаем амидные образования конечных продуктов.Экспериментальная часть. Ряд новых 2-[6-(1,2,4-оксадиазол-5-ил)-, 2-[7-(1,2,4-оксадиазол-5-ил)-, 2-[8-(1,2,4-оксадиазол-5-ил)-[1,2,4]триазоло[4,3-а] пиридин-3-ил]ацетамидов был получен с хорошими выходами, а их структуры подтверждены методом ЯМР 1H-спектроскопии. Также был проведен прогноз и изучение их фармакологической активности.Выводы. Синтетический подход получения ранее неизвестных представителей 2-[(1,2,4-оксадиазол-5-ил)-[1,2,4]триазоло4,3-а]пиридин-3-ил]ацетамидов может быть применен для синтеза различных функционализированных [1,2,4]триазоло[4,3-а]пиридиновых производных., Конденсовані гетероциклічні 1,2,4-триазоли привертають велику увагу до себе різноманітністю цікавих біологічних властивостей.Мета роботи. Розробити метод синтезу нових 2-[(1,2,4-оксадіазол-5-іл)-[1,2,4]триазоло[4,3-а]піридин-3-іл]ацетамідів та провести біологічну оцінку синтезованих сполук.Результати та їх обговорення. Синтезовано низку нових похідних ацетамідів, яка складається з 32 аналогів, що містять 1,2,4-оксадіазольний цикл у 6, 7 та 8 положеннях. Зручна схема синтезу починається з комерційно доступних 2-хлоропіридин-3-, 2-хлоропіридин-4-, 2-хлоропіридин-5-карбонових кислот з амідоксимами з утворенням відповідних 2-хлоро-[3-R1-1,2,4-оксадіазол-5-іл]піридинів, після чого перебігає реакція гідразинолізу з надлишком гідразин гідрату. Процес продовжується шляхом утворення ефіру з закриттям піридинового кільця, потім через гідроліз до оцтової кислоти ми отримуємо амідні утворення кінцевих продуктів.Експериментальна частина. Ряд нових 2-[6-(1,2,4-оксадіазол-5-іл)-, 2-[7-(1,2,4-оксадіазол-5-іл)-, 2-[8-(1,2,4-оксадіазол-5-іл)-[1,2,4]триазоло[4,3-а]піридин-3-іл]ацетамідів був отриманий з добрими виходами, а їх структури підтверджені методом ЯМР 1H-спектроскопії. Також було зроблено прогноз та вивчення їх фармакологічної активності.Висновки. Синтетичний підхід до отримання раніше невідомих представників 2-[(1,2,4-оксадіазол-5-іл)-[1,2,4]триазоло[4,3-а]піридин-3-іл]ацетамідів може бути застосований для синтезу різноманітних функціоналізованих [1,2,4]триазоло[4,3-а]піридинових похідних.

Published
2019

215. Study of energy response and resolution of the ATLAS barrel calorimeter to hadrons of energies from 20 to 350 GeV

Author

Abat, E., Abdallah, J.M., Addy, T.N., Adragna, P., Aharrouche, M., Ahmad, A., Akesson, T.P.A., Aleksa, M., Alexa, C., Anderson, K., Anghinolfi, F., Antonaki, A., Arabidze, G., Arik, E., Baker, O.K., Banfi, D., Baron, S., Beck, H.P., Belhorma, B., Benchekroun, D., Benjamin, D.P., Benslama, K., Bergeaas Kuutmann, E., Bertelsen, H., Binet, S., Biscarat, C., Boldea, V., Bondarenko, V.G., Boonekamp, M., Bosman, M., Bourdarios, C., Burckhart Chromek, D., Bychkov, V., Callahan, J., Calvet, D., Canneri, M., Capeáns Garrido, M., Caprini, M., Cardiel Sas, L., Carli, T., Carminati, L., Carvalho, J., Cascella, M., Castillo, M.V., Catinaccio, A., Cavalli Sforza, M., Cavalli, D., Cavasinni, V., Cetin, S.A., Chen, H., Cherkaoui, R., Chevallier, F., Ciobotaru, M., Citterio, M., Cleland, B., Cogneras, E., Conde Muino, P., Consonni, M., Constantinescu, S., Cornelissen, T., Corso Radu, A., Costa, G., Cwetanski, P., Da Silva, D., Dam, M., Danielsson, H.O., Dannheim, D., Davidek, T., De, K., Defay, P.O., Dekhissi, B., Del Peso, J., Delmastro, M., Del Prete, T., Derue, F., Di Ciaccio, L., Di Girolamo, B., Dita, S., Dittus, F., Djama, F., Djobava, T., Dobson, M., Dolgoshein, B.A., Dotti, A., Drake, G., Dressnandt, N., Driouchi, C., Ebenstein, W.L., Eerola, P., Efthymiopoulos, I., Egorov, K., Eifert, T.F., El Kacimi, M., Etienvre, A.I., Fabich, A., Fakhr-Edine, A.I., Fanti, M., Farbin, A., Farthouat, P., Fassouliotis, D., Fayard, L., Febbraro, R., Fedin, O.L., Fenyuk, A., Ferrari, R., Ferreira, B.C., Ferrer, A., Filippini, G., Fournier, D., Francavilla, P., Francis, D., Froeschl, R., Froidevaux, D., Fullana, E., Gadomski, S., Gagnon, P., Gameiro, S., Garcia, R., Ghodbane, N., Giakoumopoulou, V., Giangiobbe, V., Giokaris, N., Glonti, G., Gollub, N., Gomes, A., Gomez, M.D., González, V., Gorini, B., Goujdami, D., Grahn, K.J., Grenier, P., Grigalashvili, N., Grishkevich, Y., Gruwe, M., Guicheney, C., Gupta, A., Haeberli, C., Hajduk, Z., Hakobyan, H., Hance, M., Hansen, P.H., Harvey, A., Jr., Henriques Correia, A., Hervas, L., Higon, E., Hoffman, J., Hostachy, J.Y., Hruska, I., Hubaut, F., Hulsbergen, W., Hurwitz, M., Iconomidou-Fayard, L., Jen-La Plante, I., Johansson, P.D.C., Jon-And, K., Joos, M., Jorgensen, S., Kaczmarska, A., Kado, M., Karyukhin, A., Kataoka, M., Kayumov, F., Kazarov, A., Keener, P.T., Kekelidze, G.D., Kerschen, N., Khoriauli, G., Khramov, E., Khristachev, A., Khubua, J., Kittelmann, T.H., Klinkby, E., Koffas, T., Kolos, S., Konovalov, S.P., Kopikov, S., Korolkov, I., Kovalenko, S., Kowalski, T.Z., Krüger, K., Kramarenko, V., Kudin, L.G., Kulchitsky, Y., Lafaye, R., Laforge, B., Lampl, W., Lanni, F., Laplace, S., Le Bihan, A.C., Lechowski, M., Ledroit-Guillon, F., Lehmann, G., Leitner, R., Lelas, D., Liang, Z., Lichard, P., Lokajicek, M., Louchard, L., Loureiro, K., Lucotte, A., Luehring, F., Lundberg, B., Lund-Jensen, B., Ma, H., Mackeprang, R., Maio, A., Maleev, V.P., Malek, F., Maneira, J., Mandelli, L., Mazzanti, M., Manousakis, A., Mapelli, L., Marques, C., Martin, F., McFarlane, K.W., Mchedlidze, G., McPherson, R., Meirosu, C., Meng, Z., Miagkov, A., Mialkovski, V., Milstead, D., Minashvili, I., Mindur, B., Mitsou, V.A., Monnier, E., Morozov, S.V., Mosidze, M., Mouraviev, S.V., Munar, A., Nadtochi, A.V., Negri, A., Nemecek, S., Nessi, M., Nesterov, S.Y., Newcomer, F.M., Nikitine, I., Nikolic-Audit, I., Ogren, H., Oh, S.H., Oleshko, S.B., Olszowska, J., Onofre, A., Padilla Aranda, C., Paganis, S., Pallin, D., Pantea, D., Paolone, V., Parsons, J., Pasqualucci, E., Passmore, M.S., Patrichev, S., Peez, M., Perez Reale, V., Perini, L., Peshekhonov, V.D., Petersen, J., Petersen, T.C., Petti, R., Pilcher, J., Pina, J., Pinto, B., Podlyski, F., Poggioli, L., Poveda, J., Pralavorio, P., Pribyl, L., Price, M.J., Prieur, D., Puigdengoles, C., Puzo, P., Rajagopalan, S., Rembser, C., Ridel, M., Riu, I., Roda, C., Rohne, O., Romaniouk, A., Rousseau, D., Ruiz, A., Rusakovich, N., Rust, D., Ryabov, Y.F., Ryjov, V., Salto, O., Salvachua, B., Sanchis, E., Santamarina Rios, C., Santoni, C., Saraiva, J.G., Sarri, F., Sauvage, G., Says, L.P., Schaefer, M., Schegelsky, V.A., Schlager, G., Schlereth, J., Schmitt, C., Schwemling, P., Schwindling, J., Seixas, J.M., Seliverstov, D.M., Serin, L., Shalanda, N., Shin, T., Shmeleva, A., Silva, J., Simion, S., Simonyan, M., Sloper, J.E., Smirnov, S.Yu., Smirnova, L., Solans, C., Solodkov, A., Solovianov, O., Soloviev, I., Sosnovtsev, V.V., Spanò, F., Speckmeyer, P., Stancu, S., Stanek, R., Starchenko, E., Straessner, A., Suchkov, S.I., Suk, M., Szczygiel, R.R., Tarrade, F., Tartarelli, F., Tas, P., Tayalati, Y., Teuscher, R., Thioye, M., Tikhomirov, V.O., Tisserant, S., Torres, J., Tremblet, L., Tsiareshka, P., Tsiskaridze, V., Unal, G., Unel, G., Usai, G., Valero, A., Valkar, S., Valls, J.A., Van Berg, R., Vandelli, W., Vannucci, F., Vartapetian, A., Vassilakopoulos, V.I., Vassilieva, L., Vazeille, F., Vetter-Cole, Y., Vichou, I., Vinogradov, V., Vivarelli, I., Volpi, M., Wang, C., Werner, P., Wheeler, S., Wiesmann, M., Wilkens, H., Williams, H.H., Wingerter-Seez, I., Yasu, Y., Zaitsev, A., Zenin, A., Zenis, T., Zenonos, Z., Zhang, H., and Zhou, N.

Published
2010
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217. Improved exclusion limit for light dark matter from e+e− annihilation in NA64

Author

Andreev, Yu. M., primary, Banerjee, D., additional, Bernhard, J., additional, Bondì, M., additional, Burtsev, V. E., additional, Celentano, A., additional, Charitonidis, N., additional, Chumakov, A. G., additional, Cooke, D., additional, Crivelli, P., additional, Depero, E., additional, Dermenev, A. V., additional, Donskov, S. V., additional, Dusaev, R. R., additional, Enik, T., additional, Feshchenko, A., additional, Frolov, V. N., additional, Gardikiotis, A., additional, Gerassimov, S. G., additional, Gninenko, S. N., additional, Hösgen, M., additional, Jeckel, M., additional, Kachanov, V. A., additional, Karneyeu, A. E., additional, Kekelidze, G., additional, Ketzer, B., additional, Kirpichnikov, D. V., additional, Kirsanov, M. M., additional, Kolosov, V. N., additional, Konorov, I. V., additional, Kovalenko, S. G., additional, Kramarenko, V. A., additional, Kravchuk, L. V., additional, Krasnikov, N. V., additional, Kuleshov, S. V., additional, Lyubovitskij, V. E., additional, Lysan, V., additional, Marsicano, L., additional, Matveev, V. A., additional, Mikhailov, Yu. V., additional, Molina Bueno, L., additional, Peshekhonov, D. V., additional, Polyakov, V. A., additional, Radics, B., additional, Rojas, R., additional, Rubbia, A., additional, Samoylenko, V. D., additional, Sieber, H., additional, Shchukin, D., additional, Tikhomirov, V. O., additional, Tlisova, I., additional, Toropin, A. N., additional, Trifonov, A. Yu., additional, Ulloa, P., additional, Vasilishin, B. I., additional, Vasquez Arenas, G., additional, Volkov, P. V., additional, and Volkov, V. Yu., additional

Published
2021
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224. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL NAPHTHOQUINONE DERIVATIVES CONTAINING 1,2,4-TRIAZINE AND 1,2,4-TRIAZOLE MOIETIES.

Author

Polish, N. V., Nesterkina, M. V., Protunkevych, M. S., Karkhut, A. I., Marintsov, N. G., Polovkovych, S. V., Kravchenko, I. A., Voskoboinik, O. Y., Kovalenko, S. I., and Karpenko, O. V.

Subjects
NAPHTHOQUINONE, ANTICONVULSANTS, ANTIDEPRESSANTS, ELECTROSPRAY ionization mass spectrometry, ELECTROCONVULSIVE therapy, HETEROCYCLIC compounds
Abstract

Copyright of Issues of Chemistry & Chemical Technology / Voprosy Khimii & Khimicheskoi Tekhnologii is the property of Ukrainian State University of Chemical Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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225. Study of the response of the ATLAS central calorimeter to pions of energies from 3 to 9 GeV

Author

Abat, E., Abdallah, J.M., Addy, T.N., Adragna, P., Aharrouche, M., Ahmad, A., Akesson, T.P.A., Aleksa, M., Alexa, C., Anderson, K., Anghinolfi, F., Antonaki, A., Arabidze, G., Arik, E., Baker, O.K., Banfi, D., Baron, S., Beck, H.P., Belhorma, B., Benchekroun, D., Benjamin, D.P., Benslama, K., Bergeaas Kuutmann, E., Bertelsen, H., Binet, S., Biscarat, C., Boldea, V., Bondarenko, V.G., Boonekamp, M., Bosman, M., Bourdarios, C., Burckhart Chromek, D., Bychkov, V., Callahan, J., Calvet, D., Canneri, M., Capeáns Garrido, M., Caprini, M., Cardiel Sas, L., Carli, T., Carminati, L., Carvalho, J., Cascella, M., Castillo, M.V., Catinaccio, A., Cavalli Sforza, M., Cavalli, D., Cavasinni, V., Cetin, S.A., Chen, H., Cherkaoui, R., Chevallier, F., Ciobotaru, M., Citterio, M., Cleland, B., Cogneras, E., Conde Muino, P., Consonni, M., Constantinescu, S., Cornelissen, T., Corso Radu, A., Costa, G., Cwetanski, P., Da Silva, D., Dam, M., Danielsson, H.O., Dannheim, D., Davidek, T., De, K., Defay, P.O., Dekhissi, B., Del Peso, J., Delmastro, M., Del Prete, T., Derue, F., Di Ciaccio, L., Di Girolamo, B., Dita, S., Dittus, F., Djama, F., Djobava, T., Dobson, M., Dolgoshein, B.A., Dotti, A., Drake, G., Dressnandt, N., Driouchi, C., Ebenstein, W.L., Eerola, P., Efthymiopoulos, I., Egorov, K., Eifert, T.F., El Kacimi, M., Etienvre, A.I., Fabich, A., Fakhr-Edine, A.I., Fanti, M., Farbin, A., Farthouat, P., Fassouliotis, D., Fayard, L., Febbraro, R., Fedin, O.L., Fenyuk, A., Ferrari, R., Ferreira, B.C., Ferrer, A., Filippini, G., Fournier, D., Francavilla, P., Francis, D., Froeschl, R., Froidevaux, D., Fullana, E., Gadomski, S., Gagnon, P., Gameiro, S., Garcia, R., Ghodbane, N., Giakoumopoulou, V., Giangiobbe, V., Giokaris, N., Glonti, G., Gollub, N., Gomes, A., Gomez, M.D., Gorini, B., Goujdami, D., Grahn, K.J., Grenier, P., Grigalashvili, N., Grishkevich, Y., Gruwe, M., Guicheney, C., Gupta, A., Haeberli, C., Hajduk, Z., Hakobyan, H., Hance, M., Hansen, P.H., Harvey, A., Jr., Henriques Correia, A., Hervas, L., Higon, E., Hoffman, J., Hostachy, J.Y., Hruska, I., Hubaut, F., Hulsbergen, W., Hurwitz, M., Iconomidou-Fayard, L., Jen-La Plante, I., Johansson, P.D.C., Jon-And, K., Joos, M., Jorgensen, S., Kaczmarska, A., Kado, M., Karyukhin, A., Kataoka, M., Kayumov, F., Kazarov, A., Keener, P.T., Kekelidze, G.D., Kerschen, N., Khoriauli, G., Khramov, E., Khristachev, A., Khubua, J., Kittelmann, T.H., Klinkby, E., Koffas, T., Kolos, S., Konovalov, S.P., Kopikov, S., Korolkov, I., Kovalenko, S., Kowalski, T.Z., Krüger, K., Kramarenko, V., Kudin, L.G., Kulchitsky, Y., Lafaye, R., Laforge, B., Lampl, W., Lanni, F., Laplace, S., Le Bihan, A.C., Lechowski, M., Ledroit-Guillon, F., Lehmann, G., Leitner, R., Lelas, D., Liang, Z., Lichard, P., Lokajicek, M., Louchard, L., Loureiro, K., Lucotte, A., Luehring, F., Lundberg, B., Lund-Jensen, B., Ma, H., Mackeprang, R., Maio, A., Maleev, V.P., Malek, F., Maneira, J., Mandelli, L., Mazzanti, M., Manousakis, A., Mapelli, L., Marques, C., Martin, F., McFarlane, K.W., Mchedlidze, G., McPherson, R., Meirosu, C., Meng, Z., Miagkov, A., Mialkovski, V., Milstead, D., Minashvili, I., Mindur, B., Mitsou, V.A., Monnier, E., Morozov, S.V., Mosidze, M., Mouraviev, S.V., Munar, A., Nadtochi, A.V., Negri, A., Nemecek, S., Nessi, M., Nesterov, S.Y., Newcomer, F.M., Nikitine, I., Nikolic-Audit, I., Ogren, H., Oh, S.H., Oleshko, S.B., Olszowska, J., Onofre, A., Padilla Aranda, C., Paganis, S., Pallin, D., Pantea, D., Paolone, V., Parsons, J., Pasqualucci, E., Passmore, M.S., Patrichev, S., Peez, M., Perez Reale, V., Perini, L., Peshekhonov, V.D., Petersen, J., Petersen, T.C., Petti, R., Pilcher, J., Pina, J., Pinto, B., Podlyski, F., Poggioli, L., Poveda, J., Pralavorio, P., Pribyl, L., Price, M.J., Prieur, D., Puigdengoles, C., Puzo, P., Rajagopalan, S., Rembser, C., Ridel, M., Riu, I., Roda, C., Rohne, O., Romaniouk, A., Rousseau, D., Ruiz, A., Rusakovich, N., Rust, D., Ryabov, Y.F., Ryjov, V., Salto, O., Salvachua, B., Santamarina Rios, C., Santoni, C., Saraiva, J.G., Sarri, F., Sauvage, G., Says, L.P., Schaefer, M., Schegelsky, V.A., Schlager, G., Schlereth, J., Schmitt, C., Schwemling, P., Schwindling, J., Seixas, J.M., Seliverstov, D.M., Serin, L., Shalanda, N., Shin, T., Shmeleva, A., Silva, J., Simion, S., Simonyan, M., Sloper, J.E., Smirnov, S.Yu., Smirnova, L., Solans, C., Solodkov, A., Solovianov, O., Soloviev, I., Sosnovtsev, V.V., Spanò, F., Speckmeyer, P., Stancu, S., Stanek, R., Starchenko, E., Straessner, A., Suchkov, S.I., Suk, M., Szczygiel, R.R., Tarrade, F., Tartarelli, F., Tas, P., Tayalati, Y., Teuscher, R., Thioye, M., Tikhomirov, V.O., Tisserant, S., Tremblet, L., Tsiareshka, P., Unal, G., Unel, G., Usai, G., Valero, A., Valkar, S., Valls, J.A., Van Berg, R., Vandelli, W., Vannucci, F., Vartapetian, A., Vassilakopoulos, V.I., Vassilieva, L., Vazeille, F., Vetter-Cole, Y., Vichou, I., Vinogradov, V., Vivarelli, I., Volpi, M., Wang, C., Werner, P., Wheeler, S., Wiesmann, M., Wilkens, H., Williams, H.H., Wingerter-Seez, I., Yasu, Y., Zaitsev, A., Zenin, A., Zenis, T., Zenonos, Z., Zhang, H., and Zhou, N.

Published
2009
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226. Search for pseudoscalar bosons decaying into e+e- pairs

Author

Banerjee, D, Bernhard, J, Burtsev, V, Chumakov, A, Cooke, D, Crivelli, P, Depero, E, Dermenev, A, Donskov, S, Dusaev, R, Enik, T, Charitonidis, N, Feshchenko, A, Frolov, V, Gardikiotis, A, Gerassimov, S, Girod, S, Gninenko, S, Hoesgen, M, Kachanov, V, Karneyeu, A, Kekelidze, G, Ketzer, B, Kirpichnikov, D, Kirsanov, M, Kolosov, V, Konorov, I, Kovalenko, S, Kramarenko, V, Kravchuk, L, Krasnikov, N, Kuleshov, S, Lyubovitskij, V, Lysan, V, Matveev, V, Mikhailov, Yu, Molina, L, Peshekhonov, D, Polyakov, V, Radics, B, Rojas, R, Rubbia, A, Samoylenko, V, Shchukin, D, Tikhomirov, V, Tlisova, I, Toropin, A, Trifonov, A, Vasilishin, B, Vasquez, G, Volkov, P, Volkov, V, and Ulloa, P

Subjects
Particle Physics - Experiment
Abstract

We report the results of a search for a light pseudoscalar particle $a$ that couples to electrons and decays to $e^+e^-$ performed using the high-energy CERN SPS H4 electron beam. If such pseudoscalar with a mass $\simeq 17$ MeV exists, it could explain the ATOMKI anomaly. We used the NA64 data samples collected in the "visible mode" configuration with total statistics corresponding to $8.4\times 10^{10}$ electrons on target (EOT) in 2017 and 2018. In order to increase sensitivity to small coupling parameter $\epsilon$ we used also the data collected in 2016 - 2018 in the "invisible mode" configuration of NA64 with a total statistics corresponding to $2.84\times 10^{11}$ EOT. A thorough analysis of both these data samples in the sense of background and efficiency estimations was already performed and reported in our previous papers devoted to the search for light vector particles and axion-like particles (ALP). In this work we recalculate the signal yields, which are different due to different cross section and life time of a pseudoscalar particle $a$, and perform a new statistical analysis. As a result, the region of the two dimensional parameter space $m_a - \epsilon$ in the mass range from 1 to 17.1 MeV is excluded. At the mass of the ATOMKI anomaly the values of $\epsilon$ in the range $2.1 \times 10^{-4} < \epsilon < 3.2 \times 10^{-4}$ are excluded.

Published
2021

227. Cellular electrophysiological effects of botulinum toxin A on neonatal rat cardiomyocytes and on cardiomyocytes derived from human-induced pluripotent stem cells.

Author

Nizamieva A, Frolova S, Slotvitsky M, Kovalenko S, Tsvelaya V, Nikitina A, Sergeevichev D, and Agladze K

Subjects
Humans, Rats, Animals, Myocytes, Cardiac, Animals, Newborn, Action Potentials, Anti-Arrhythmia Agents pharmacology, Induced Pluripotent Stem Cells, Chitosan, Botulinum Toxins
Abstract

Botulinum toxin A is a well-known neurotransmitter inhibitor with a wide range of applications in modern medicine. Recently, botulinum toxin A preparations have been used in clinical trials to suppress cardiac arrhythmias, especially in the postoperative period. Its antiarrhythmic action is associated with inhibition of the nervous system of the heart, but its direct effect on heart tissue remains unclear. Accordingly, we investigate the effect of botulinum toxin A on isolated cardiac cells and on layers of cardiac cells capable of conducting excitation. Cardiomyocytes of neonatal rat pups and human cardiomyocytes obtained through cell reprogramming were used. A patch-clamp study showed that botulinum toxin A inhibited fast sodium currents and L-type calcium currents in a dose-dependent manner, with no apparent effect on potassium currents. Optical mapping showed that in the presence of botulinum toxin A, the propagation of the excitation wave in the layer of cardiac cells slows down sharply, conduction at high concentrations becomes chaotic, but reentry waves do not form. The combination of botulinum toxin A with a preparation of chitosan showed a stronger inhibitory effect by an order of magnitude. Further, the inhibitory effect of botulinum toxin A is not permanent and disappears after 12 days of cell culture in a botulinum toxin A-free medium. The main conclusion of the work is that the antiarrhythmic effect of botulinum toxin A found in clinical studies is associated not only with depression of the nervous system but also with a direct effect on heart tissue. Moreover, the combination of botulinum toxin A and chitosan reduces the effective dose of botulinum toxin A., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2023
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232. Answers to referees on SND@LHC TP

Author

Ahdida, C, Albanese, R, Alexandrov, A, Andreini, M, Anokhina, A, Bay, A, Bestmann, P, Betancourt, C, Bezshyiko, I, Blanco, A, Bogomilov, M, Bondarenko, K, Bonivento, W M, Boisseaux-Bourgeois, P, Boyarsky, A, Buonocore, L, Buonaura, A, Buontempo, S, Cafaro, V, Callignon, M, Camporesi, T, Campanelli, M, Canale, V, Cerutti, F, Charitonidis, N, Chernyavskiy, M, Choi, K-Y, Cholak, S, Cicero, V, Conaboy, A P, Congedo, L, Crespo, O, Cristinziani, M, Crupano, A, Dallavalle, G M, Datwyler, A, D'Ambrosio, N, Dashkina, A, De Carvalho Saraiva, J, De Bryas Dexmiers D'Archiac, P T, De Lellis, G, De Magistris, M, De Roeck, A, De Rujula, A, De Serio, M, De Simone, D, Dedenko, L, Di Crescenzo, A, Di Giulio, L, Dolmatov, A, Durhan, O, Fasanella, D, Fedotovs, F, Ferrillo, M, Ferro-Luzzi, M, Fini, R A, Fonte, P, Fresa, R, Galati, G, Gall, J, Garcia Alia, R, Gentile, V, Giordano, V, Golovatiuk, A, Golutvin, A, Gorbounov, P, Gorshenkov, M, Graverini, E, Grenard, J-L, Guler, A M, Haefeli, G J, van Herwijnen, E, Iaselli, G, Iengo, P, Ilieva, S, Infantino, A, Iuliano, A, Jacobsson, R, Jonker, M, Kamiscioglu, C, Karyotakis, Y, Khalikov, E, Kim, Y G, Kim, S H, Kolev, D I, Komatsu, M, Konovalova, N, Kovalenko, S, Krasilnikova, I, Kuleshov, S, Lacker, H M, Lantwin, O, Lauria, A, Lee, K S, Lee, K Y, Leonardo, N, Lerner, G, Lo Meo, S, Loschiavo, V P, Lopes, L, Magnan, A, Maietta, M, Malinin, A, Maurer, Y, Managadze, A K, Marsh, S, Miano, A, Mikulenko, A, Montanari, A, Montesi, M C, Naka, T, Navarria, F L, Ninin, P, Ogawa, S, Okateva, N, Osborne, J, Owtscharenko, N, Owen, P H, Ovchynnikov, M, Park, B D, Passeggio, G, Pastore, A, Patel, M, Patrizii, L, Petrov, A, Podgrudkov, D, Petkov, G L, Petridis, K, Polukhina, N, Prelipcean, D, Prota, A, Queiroz, F, Quercia, A, Ratnikov, F, Redi, F, Reghunath, A, Rodrigues Cavalcante, A B, Rodrigues Fernandez, J, Roganova, T, Rovelli, T, Ruchayskiy, O, Ruf, T, Sabate Gilarte, M, Sanchez Galan, F, Santos Diaz, P, Schneider, O, Sekhniaidze, G, Serra, N, Shaposhnikov, M, Shchedrina, T, Shchutska, L, Shevchenko, V, Shibuya, H, Shirobokov, S, Shmanin, E, Simone, S, Sirri, G, Soares, G, Sohn, J Y, Souaya, M, Starkov, N, Tastet, J L, Timiryasov, I, Tioukov, V, Tosi, N, Trippl, C, Tramontano, F, Tsenov, R, Ursov, E, Ustyuzhanin, A, Vankova-Kirilova, G, Vendeuvre, C, Visone, C, Wanke, R, Woo, J-K, Yoon, C S, Zamora-Saa, J, and Zaffaroni, E

Subjects
Detectors and Experimental Techniques
Abstract

Answers to the LHCC referees concerning the SND@LHC Technical Proposal

Published
2021

233. Constraints on New Physics in Electron g-2 from a Search for Invisible Decays of a Scalar, Pseudoscalar, Vector, and Axial Vector

Author

Andreev, Yu. M., Banerjee, D., Bernhard, J., Burtsev, V. E., Chumakov, A. G., Cooke, D., Crivelli, P., Depero, E., Dermenev, A. V., Donskov, S. V., Dusaev, R. R., Enik, T., Charitonidis, N., Feshchenko, A., Frolov, V. N., Gardikiotis, A., Gerassimov, S. G., Gninenko, S. N., Hösgen, M., Kachanov, V. A., Karneyeu, A. E., Kekelidze, G., Ketzer, B., Kirpichnikov, D. V., Kirsanov, M. M., Kolosov, V. N., Konorov, I. V., Kovalenko, S. G., Kramarenko, V. A., Kravchuk, L. V., Krasnikov, N. V., Kuleshov, S. V., Lyubovitskij, V. E., Lysan, V., Matveev, V. A., Mikhailov, Yu. V., Molina Bueno, L., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Rojas, R., Rubbia, A., Samoylenko, V. D., Sieber, H., Shchukin, D., Tikhomirov, V. O., Tlisova, I., Toropin, A. N., Trifonov, A. Yu., Vasilishin, B. I., Volkov, P. V., and Volkov, V. Yu.

Abstract

We performed a search for a new generic X boson, which could be a scalar (S), pseudoscalar (P), vector (V), or an axial vector (A) particle produced in the 100 GeV electron scattering off nuclei, e−Z→e−ZX, followed by its invisible decay in the NA64 experiment at CERN. No evidence for such a process was found in the full NA64 dataset of 2.84×1011 electrons on target. We place new bounds on the S, P, V, A coupling strengths to electrons, and set constraints on their contributions to the electron anomalous magnetic moment ae, |ΔaX|≲10−15–10−13 for the X mass region 1 MeV≲mX≲1 GeV. These results are an order of magnitude more sensitive compared to the current accuracy on ae from the electron g−2 experiments and recent high-precision determination of the fine structure constant.

Published
2021

234. SND@LHC - Scattering and Neutrino Detector at the LHC

Author

Ahdida, C, Albanese, R, Alexandrov, A, Andreini, M, Anokhina, A, Bay, A, Bestmann, P, Betancourt, C, Bezshyiko, I, Blanco, A, Bogomilov, M, Bondarenko, K, Bonivento, W M, Boisseaux-Bourgeois, P, Boyarsky, A, Buonocore, L, Buonaura, A, Buontempo, S, Cafaro, V, Callignon, M, Camporesi, T, Campanelli, M, Canale, V, Cerutti, F, Charitonidis, N, Chernyavskiy, M, Choi, K-Y, Cholak, S, Cicero, V, Conaboy, A P, Congedo, L, Crespo, O, Cristinziani, M, Crupano, A, Dallavalle, G M, Datwyler, A, D'Ambrosio, N, Dashkina, A, De Carvalho Saraiva, J, De Bryas Dexmiers D'Archiac, P T, De Lellis, G, De Magistris, M, De Roeck, A, De Rujula, A, De Serio, M, De Simone, D, Dedenko, L, Di Crescenzo, A, Di Giulio, L, Dolmatov, A, Durhan, O, Fasanella, D, Fedotovs, F, Ferrillo, M, Ferro-Luzzi, M, Fini, R A, Fonte, P, Fresa, R, Galati, G, Gall, J, Garcia Alia, R, Gentile, V, Giordano, V, Golovatiuk, A, Golutvin, A, Gorbounov, P, Gorshenkov, M, Graverini, E, Grenard, J-L, Guler, A M, Haefeli, G J, van Herwijnen, E, Iaselli, G, Iengo, P, Ilieva, S, Infantino, A, Iuliano, A, Jacobsson, R, Jonker, M, Kamiscioglu, C, Karyotakis, Y, Khalikov, E, Kim, Y G, Kim, S H, Kolev, D I, Komatsu, M, Konovalova, N, Kovalenko, S, Krasilnikova, I, Kuleshov, S, Lacker, H M, Lantwin, O, Lauria, A, Lee, K S, Lee, K Y, Leonardo, N, Lerner, G, Lo Meo, S, Loschiavo, V P, Lopes, L, Magnan, A, Maietta, M, Malinin, A, Maurer, Y, Managadze, A K, Marsh, S, Miano, A, Mikulenko, A, Montanari, A, Montesi, M C, Naka, T, Navarria, F L, Ninin, P, Ogawa, S, Okateva, N, Osborne, J, Owtscharenko, N, Owen, P H, Ovchynnikov, M, Park, B D, Passeggio, G, Pastore, A, Patel, M, Patrizii, L, Petrov, A, Podgrudkov, D, Petkov, G L, Petridis, K, Polukhina, N, Prelipcean, D, Prota, A, Queiroz, F, Quercia, A, Ratnikov, F, Redi, F, Reghunath, A, Rodrigues Cavalcante, A B, Rodrigues Fernandez, J, Roganova, T, Rovelli, T, Ruchayskiy, O, Ruf, T, Sabate Gilarte, M, Sanchez Galan, F, Santos Diaz, P, Schneider, O, Sekhniaidze, G, Serra, N, Shaposhnikov, M, Shchedrina, T, Shchutska, L, Shevchenko, V, Shibuya, H, Shirobokov, S, Shmanin, E, Simone, S, Sirri, G, Soares, G, Sohn, J Y, Souaya, M, Starkov, N, Tastet, J L, Timiryasov, I, Tioukov, V, Tosi, N, Trippl, C, Tramontano, F, Tsenov, R, Ursov, E, Ustyuzhanin, A, Vankova-Kirilova, G, Vendeuvre, C, Visone, C, Wanke, R, Woo, J-K, Yoon, C S, Zamora-Saa, J, and Zaffaroni, E

Subjects
Physics::Instrumentation and Detectors, High Energy Physics::Experiment, Detectors and Experimental Techniques
Abstract

SND@LHC is a proposed, compact and stand-alone experiment to perform measurements with neutrinos produced at the LHC in an hitherto unexplored pseudo-rapidity region of $7.2 < \eta < 8.6$, complementary to all the other experiments at the LHC. The experiment is to be located 480 m downstream of IP1 in the unused TI18 tunnel. The first phase aims at operating the detector throughout LHC Run 3 to collect a total integrated luminosity of 150 fb$^{−1}$. Following the review of the Letter of Intent [1], submitted in August 2020, LHCC recommended the collaboration to proceed with the preparation of a Technical Proposal (TP), reported herein.

Published
2021

235. Improved exclusion limit for light dark matter from $e^+e^-$ annihilation in NA64

Author

Andreev, Yu. M., Banerjee, D., Bernhard, J., Bondì, M., Burtsev, V. E., Celentano, A., Charitonidis, N., Chumakov, A. G., Cooke, D., Crivelli, P., Depero, E., Dermenev, A. V., Donskov, S. V., Dusaev, R. R., Enik, T., Feshchenko, A., Frolov, V. N., Gardikiotis, A., Gerassimov, S. G., Gninenko, S. N., Hösgen, M., Jeckel, M., Kachanov, V. A., Karneyeu, A. E., Kekelidze, G., Ketzer, B., Kirpichnikov, D. V., Kirsanov, M. M., Kolosov, V. N., Konorov, I. V., Kovalenko, S. G., Kramarenko, V. A., Kravchuk, L. V., Krasnikov, N. V., Kuleshov, S. V., Lyubovitskij, V. E., Lysan, V., Marsicano, L., Matveev, V. A., Mikhailov, Yu. V., Molina Bueno, L., Peshekhonov, D. V., Polyakov, V. A., Radics, B., Rojas, R., Rubbia, A., Samoylenko, V. D., Sieber, H., Shchukin, D., Tikhomirov, V. O., Tlisova, I., Toropin, A. N., Trifonov, A. Yu., Ulloa, P., Vasilishin, B. I., Vasquez Arenas, G., Volkov, P. V., and Volkov, V. Yu.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), hep-ex, FOS: Physical sciences, hep-ph, Computer Science::Digital Libraries, Particle Physics - Experiment, Particle Physics - Phenomenology, High Energy Physics - Experiment
Abstract

The current most stringent constraints for the existence of sub-GeV dark matter coupling to Standard Model via a massive vector boson $A^\prime$ were set by the NA64 experiment for the mass region $m_{A^\prime}\lesssim 250$ MeV, by analyzing data from the interaction of $2.84\cdot10^{11}$ 100-GeV electrons with an active thick target and searching for missing-energy events. In this work, by including $A^\prime$ production via secondary positron annihilation with atomic electrons, we extend these limits in the $200$-$300$ MeV region by almost an order of magnitude, touching for the first time the dark matter relic density constrained parameter combinations. Our new results demonstrate the power of the resonant annihilation process in missing energy dark-matter searches, paving the road to future dedicated $e^+$ beam efforts., Comment: Version accepted for publication as a Letter in Phys. Rev. D

Published
2021
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236. Sensitivity of the SHiP experiment to light dark matter

Author

Ahdida, C., Akmete, A., Albanese, R., Alexandrov, A., Anokhina, A., Aoki, S., Arduini, G., Atkin, E., Azorskiy, N., Back, J. J., Bagulya, A., Baaltasar Dos Santos, F., Baranov, A., Bardou, F., Barker, G. J., Battistin, M., Bauche, J., Bay, A., Bayliss, V., Bencivenni, G., Berdnikov, A. Y., Berdnikov, Y. A., Bertani, M., Betancourt, C., Bezshyiko, I., Bezshyyko, O., Bick, D., Bieschke, S., Blanco, A., Boehm, J., Bogomilov, M., Boiarska, I., Bondarenko, K., Bonivento, W. M., Borburgh, J., Boyarsky, A., Brenner, Richard, Breton, D., Buscher, V., Buonaura, A., Buonocore, L., Buontempo, S., Cadeddu, S., Calcaterra, A., Calviani, M., Campanelli, M., Casolino, M., Charitonidis, N., Chau, P., Chauveau, J., Chepurnov, A., Chernyavskiy, M., Choi, K. -Y, Chumakov, A., Ciambrone, P., Cicero, V., Congedo, L., Cornelis, K., Cristinziani, M., Crupano, A., Dallavalle, G. M., Datwyler, A., D'Ambrosio, N., D'Appollonio, G., de Asmundis, R., De Carvalho Saraiva, J., De Lellis, G., de Magistris, M., De Roeck, A., De Serio, M., De Simone, D., Dedenko, L., Dergachev, P., Di Crescenzo, A., Di Giulio, L., Di Marco, N., Dib, C., Dijkstra, H., Dmitrenko, V., Dougherty, L. A., Dolmatov, A., Domenici, D., Donskov, S., Drohan, V., Dubreuil, A., Durhan, O., Ehlert, M., Elikkaya, E., Enik, T., Etenko, A., Fabbri, F., Fedin, O., Fedotovs, F., Felici, G., Ferrillo, M., Ferro-Luzzi, M., Filippov, K., Fini, R. A., Fonte, P., Franco, C., Fraser, M., Fresa, R., Froeschl, R., Frugiuele, C., Fukuda, T., Galati, G., Gall, J., Gatignon, L., Gavrilov, G., Gentile, V., Goddard, B., Golinka-Bezshyyko, L., Golovatiuk, A., Golovtsov, V., Golubkov, D., Golutvin, A., Gorbounov, P., Gorbunov, D., Gorbunov, S., Gorkavenko, V., Gorshenkov, M., Grachev, V., Grandchamp, A. L., Graverini, E., Grenard, J. -L, Grenier, D., Grichine, V., Gruzinskii, N., Guler, A. M., Guz, Yu., Haefeli, G. J., Hagner, C., Hakobyan, H., Harris, I. W., van Herwijnen, E., Hessler, C., Hollnagel, A., Hosseini, B., Hushchyn, M., Iaselli, G., Iuliano, A., Jacobsson, R., Jokovic, D., Jonker, M., Kadenko, I., Kain, V., Kaiser, B., Kamiscioglu, C., Karpenkov, D., Kershaw, K., Khabibullin, M., Khalikov, E., Khaustov, G., Khoriauli, G., Khotyantsev, A., Kim, Y. G., Kim, V., Kitagawa, N., Ko, J. -W, Kodama, K., Kolesnikov, A., Kolev, D. I., Kolosov, V., Komatsu, M., Kono, A., Konovalova, N., Kormannshaus, S., Korol, I., Korol'ko, I., Korzenev, A., Kostyukhin, V., Koukovini Platia, E., Kovalenko, S., Krasilnikova, I., Kudenko, Y., Kurbatov, E., Kurbatov, P., Kurochka, V., Kuznetsova, E., Lacker, H. M., Lamont, M., Lanfranchi, G., Lantwin, O., Lauria, A., Lee, K. S., Lee, K. Y., Levy, J. -M, Loschiavo, V. P., Lopes, L., Lopez Sola, E., Lyubovitskij, V., Maalmi, J., Magnan, A., Maleev, V., Malinin, A., Maltoni, F., Manabe, Y., Managadze, A. K., Manfredi, M., Marsh, S., Marshall, A. M., Mattelaer, O., Mefodev, A., Mermod, P., Miano, A., Mikado, S., Mikhaylov, Yu., Milstead, D. A., Mineev, O., Montanari, A., Montesi, M. C., Morishima, K., Movchan, S., Muttoni, Y., Naganawa, N., Nakamura, M., Nakano, T., Nasybulin, S., Ninin, P., Nishio, A., Novikov, A., Obinyakov, B., Ogawa, S., Okateva, N., Opitz, B., Osborne, J., Ovchynnikov, M., Owtscharenko, N., Owen, P. H., Pacholek, P., Paoloni, A., Park, B. D., Pastore, A., Patel, M., Pereyma, D., Perillo-Marcone, A., Petkov, G. L., Petridis, K., Petrov, A., Podgrudkov, D., Poliakov, V., Polukhina, N., Prieto Prieto, J., Prokudin, M., Prota, A., Quercia, A., Rademakers, A., Rakai, A., Ratnikov, F., Rawlings, T., Redi, F., Ricciardi, S., Rinaldesi, M., Rodin, Volodymyr, Rodin, Viktor, Robbe, P., Rodrigues Cavalcante, A. B., Roganova, T., Rokujo, H., Rosa, G., Rovelli, T., Ruchayskiy, O., Ruf, T., Samoylenko, V., Samsonov, V., Sanchez Galan, F., Santos Diaz, P., Sanz Ull, A., Saputi, A., Sato, O., Savchenko, E. S., Schliwinski, J. S., Schmidt-Parzefall, W., Serra, N., Sgobba, S., Shadura, O., Shakin, A., Shaposhnikov, M., Shatalov, P., Shchedrina, T., Shchutska, L., Shevchenko, V., Shibuya, H., Shirobokov, S., Shustov, A., Silverstein, S. B., Simone, S., Simoniello, R., Skorokhvatov, M., Smirnov, S., Sohn, J. Y., Sokolenko, A., Solodko, E., Starkov, N., Stoel, L., Stramaglia, M. E., Sukhonos, D., Suzuki, Y., Takahashi, S., Tastet, J. L., Teterin, P., Than Naing, S., Timiryasov, I., Tioukov, V., Tommasini, D., Torii, M., Tosi, N., Tramontano, F., Treille, D., Tsenov, R., Ulin, S., Ursov, E., Ustyuzhanin, A., Uteshev, Z., Uvarov, L., Vankova-Kirilova, G., Vannucci, F., Venturi, V., Vilchinski, S., Vincke, Heinz, Vincke, Helmut, Visone, C., Vlasik, K., Volkov, A., Voronkov, R., van Waasen, S., Wanke, R., Wertelaers, P., Williams, O., Woo, J. -K, Wurm, M., Xella, S., Yilmaz, D., Yilmazer, A. U., Yoon, C. S., Zaytsev, Yu., Zelenov, A., Zimmerman, J., Ahdida, C., Akmete, A., Albanese, R., Alexandrov, A., Anokhina, A., Aoki, S., Arduini, G., Atkin, E., Azorskiy, N., Back, J. J., Bagulya, A., Baaltasar Dos Santos, F., Baranov, A., Bardou, F., Barker, G. J., Battistin, M., Bauche, J., Bay, A., Bayliss, V., Bencivenni, G., Berdnikov, A. Y., Berdnikov, Y. A., Bertani, M., Betancourt, C., Bezshyiko, I., Bezshyyko, O., Bick, D., Bieschke, S., Blanco, A., Boehm, J., Bogomilov, M., Boiarska, I., Bondarenko, K., Bonivento, W. M., Borburgh, J., Boyarsky, A., Brenner, Richard, Breton, D., Buscher, V., Buonaura, A., Buonocore, L., Buontempo, S., Cadeddu, S., Calcaterra, A., Calviani, M., Campanelli, M., Casolino, M., Charitonidis, N., Chau, P., Chauveau, J., Chepurnov, A., Chernyavskiy, M., Choi, K. -Y, Chumakov, A., Ciambrone, P., Cicero, V., Congedo, L., Cornelis, K., Cristinziani, M., Crupano, A., Dallavalle, G. M., Datwyler, A., D'Ambrosio, N., D'Appollonio, G., de Asmundis, R., De Carvalho Saraiva, J., De Lellis, G., de Magistris, M., De Roeck, A., De Serio, M., De Simone, D., Dedenko, L., Dergachev, P., Di Crescenzo, A., Di Giulio, L., Di Marco, N., Dib, C., Dijkstra, H., Dmitrenko, V., Dougherty, L. A., Dolmatov, A., Domenici, D., Donskov, S., Drohan, V., Dubreuil, A., Durhan, O., Ehlert, M., Elikkaya, E., Enik, T., Etenko, A., Fabbri, F., Fedin, O., Fedotovs, F., Felici, G., Ferrillo, M., Ferro-Luzzi, M., Filippov, K., Fini, R. A., Fonte, P., Franco, C., Fraser, M., Fresa, R., Froeschl, R., Frugiuele, C., Fukuda, T., Galati, G., Gall, J., Gatignon, L., Gavrilov, G., Gentile, V., Goddard, B., Golinka-Bezshyyko, L., Golovatiuk, A., Golovtsov, V., Golubkov, D., Golutvin, A., Gorbounov, P., Gorbunov, D., Gorbunov, S., Gorkavenko, V., Gorshenkov, M., Grachev, V., Grandchamp, A. L., Graverini, E., Grenard, J. -L, Grenier, D., Grichine, V., Gruzinskii, N., Guler, A. M., Guz, Yu., Haefeli, G. J., Hagner, C., Hakobyan, H., Harris, I. W., van Herwijnen, E., Hessler, C., Hollnagel, A., Hosseini, B., Hushchyn, M., Iaselli, G., Iuliano, A., Jacobsson, R., Jokovic, D., Jonker, M., Kadenko, I., Kain, V., Kaiser, B., Kamiscioglu, C., Karpenkov, D., Kershaw, K., Khabibullin, M., Khalikov, E., Khaustov, G., Khoriauli, G., Khotyantsev, A., Kim, Y. G., Kim, V., Kitagawa, N., Ko, J. -W, Kodama, K., Kolesnikov, A., Kolev, D. I., Kolosov, V., Komatsu, M., Kono, A., Konovalova, N., Kormannshaus, S., Korol, I., Korol'ko, I., Korzenev, A., Kostyukhin, V., Koukovini Platia, E., Kovalenko, S., Krasilnikova, I., Kudenko, Y., Kurbatov, E., Kurbatov, P., Kurochka, V., Kuznetsova, E., Lacker, H. M., Lamont, M., Lanfranchi, G., Lantwin, O., Lauria, A., Lee, K. S., Lee, K. Y., Levy, J. -M, Loschiavo, V. P., Lopes, L., Lopez Sola, E., Lyubovitskij, V., Maalmi, J., Magnan, A., Maleev, V., Malinin, A., Maltoni, F., Manabe, Y., Managadze, A. K., Manfredi, M., Marsh, S., Marshall, A. M., Mattelaer, O., Mefodev, A., Mermod, P., Miano, A., Mikado, S., Mikhaylov, Yu., Milstead, D. A., Mineev, O., Montanari, A., Montesi, M. C., Morishima, K., Movchan, S., Muttoni, Y., Naganawa, N., Nakamura, M., Nakano, T., Nasybulin, S., Ninin, P., Nishio, A., Novikov, A., Obinyakov, B., Ogawa, S., Okateva, N., Opitz, B., Osborne, J., Ovchynnikov, M., Owtscharenko, N., Owen, P. H., Pacholek, P., Paoloni, A., Park, B. D., Pastore, A., Patel, M., Pereyma, D., Perillo-Marcone, A., Petkov, G. L., Petridis, K., Petrov, A., Podgrudkov, D., Poliakov, V., Polukhina, N., Prieto Prieto, J., Prokudin, M., Prota, A., Quercia, A., Rademakers, A., Rakai, A., Ratnikov, F., Rawlings, T., Redi, F., Ricciardi, S., Rinaldesi, M., Rodin, Volodymyr, Rodin, Viktor, Robbe, P., Rodrigues Cavalcante, A. B., Roganova, T., Rokujo, H., Rosa, G., Rovelli, T., Ruchayskiy, O., Ruf, T., Samoylenko, V., Samsonov, V., Sanchez Galan, F., Santos Diaz, P., Sanz Ull, A., Saputi, A., Sato, O., Savchenko, E. S., Schliwinski, J. S., Schmidt-Parzefall, W., Serra, N., Sgobba, S., Shadura, O., Shakin, A., Shaposhnikov, M., Shatalov, P., Shchedrina, T., Shchutska, L., Shevchenko, V., Shibuya, H., Shirobokov, S., Shustov, A., Silverstein, S. B., Simone, S., Simoniello, R., Skorokhvatov, M., Smirnov, S., Sohn, J. Y., Sokolenko, A., Solodko, E., Starkov, N., Stoel, L., Stramaglia, M. E., Sukhonos, D., Suzuki, Y., Takahashi, S., Tastet, J. L., Teterin, P., Than Naing, S., Timiryasov, I., Tioukov, V., Tommasini, D., Torii, M., Tosi, N., Tramontano, F., Treille, D., Tsenov, R., Ulin, S., Ursov, E., Ustyuzhanin, A., Uteshev, Z., Uvarov, L., Vankova-Kirilova, G., Vannucci, F., Venturi, V., Vilchinski, S., Vincke, Heinz, Vincke, Helmut, Visone, C., Vlasik, K., Volkov, A., Voronkov, R., van Waasen, S., Wanke, R., Wertelaers, P., Williams, O., Woo, J. -K, Wurm, M., Xella, S., Yilmaz, D., Yilmazer, A. U., Yoon, C. S., Zaytsev, Yu., Zelenov, A., and Zimmerman, J.

Abstract

Dark matter is a well-established theoretical addition to the Standard Model supported by many observations in modern astrophysics and cosmology. In this context, the existence of weakly interacting massive particles represents an appealing solution to the observed thermal relic in the Universe. Indeed, a large experimental campaign is ongoing for the detection of such particles in the sub-GeV mass range. Adopting the benchmark scenario for light dark matter particles produced in the decay of a dark photon, with alpha(D) = 0.1 and m(A ') = 3m(chi), we study the potential of the SHiP experiment to detect such elusive particles through its Scattering and Neutrino detector (SND). In its 5-years run, corresponding to 2 center dot 10(20) protons on target from the CERN SPS, we find that SHiP will improve the current limits in the mass range for the dark matter from about 1 MeV to 300 MeV. In particular, we show that SHiP will probe the thermal target for Majorana candidates in most of this mass window and even reach the Pseudo-Dirac thermal relic.

Published
2021
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242. The ATLAS transition radiation tracker

Author

Boldyrev, A. S., Bondarenko, V. G., Bychkov, V. N., Dolgoshein, B. A., Fedin, O. L., Gavrilenko, I. L., Gusakov, Yu. V., Grigalashvili, N., Grishkevich, Ya. V., Kantserov, V. A., Katunin, S. V., Kayumov, F. F., Kekelidze, G. D., Khabarova, E. M., Klopov, N. V., Kondratieva, N. V., Konovalov, S. P., Korotkova, N. A., Kovalenko, S. N., Kramarenko, V. A., Kudin, L. G., Kudryashov, I. A., Levterov, K. A., Lysan, V. M., Lobastov, S. P., Maleev, V. P., Mashinistov, R. Yu., Mialkovskii, V. V., Morozov, S. V., Muraviev, S. V., Nadtochii, A. V., Nikitin, N. V., Novgorodova, O. V., Novodvorskii, E. G., Oleshko, S. B., Patrichev, S. K., Peshekhonov, V. D., Romanyuk, A. S., Ryabov, Yu. F., Savenkov, A. A., Sedykh, E. V., Seliverstov, D. M., Shmeleva, A. P., Sivoklokov, S. Yu., Smirnov, S. Yu., Smirnova, L. N., Sosnovtsev, V. V., Suchkov, S. I., Sulin, V. V., Tikhomirov, V. O., Vasilieva, L. F., and Zhukov, K. I.

Published
2012
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246. Загальні аспекти впровадження систем управління в освітніх організаціях відповідно до ISO 21001:2018

Author

Kovalenko, S. M., Romelashvili, O. S., Zborovska, T. V., and Blagun, O. D.

Subjects
система управління, освіта, освітні послуги, міжнародний стандарт, процесний підхід, ризик-орієнтоване мислення, система управления, образование, образовательные услуги, международный стандарт, процессный подход, риск-ориентированное мышление, УДК 006.015.5, management system, education, educational services, international standard, process approach, risk-based thinking, UDC 006.015.5
Abstract

Aim. Analyze the requirements to and specific features of introduction of ISO 21001:2018 – “Educational Organizations. Management Systems for Educational Organizations. Requirements with Guidance for Use”.Results. On the whole, the international standard ISO 21001:2018 represents a management tool for organizations providing the educational products and services that are willing and capable of satisfying the expected needs of the learners. The educational organizations promoting the compliance with ISO 21001:2018 benefit from the enhancing efficiency of educational organization management systems, continuous monitoring of the establishment and the management processes for compliance with the mission, satisfaction of the needs and expectations of consumers of the services, individual approach toward training, expanding the involvement of the interested parties and facilitating the investments.Conclusions. This paper proves that ISO 21001:2018 is based on process approach, risk-based thinking and performance that is based on task completion in the Plan-Do-Check-Act (or PDCA) sequence. It has been established that all requirements set forth in ISO 21001:2018 are generic and intended to be applicable to any educational institution regardless of the form, terms and methods of training. By introducing the management system, the educational organizations will demonstrate their ability to maintain competencies through teaching, learning or research, and will further enhance the satisfaction of the learners, personnel and other interested parties by way of efficient application of the management system while steadily improving their own performance., Целью работы является анализ требований и особенностей внедрения ISO 21001:2018 «Образовательные организации. Системы управления в образовательных организациях. Требования и руководство по применению».Результаты. В целом международный стандарт ISO 21001:2018 представляет собой инструмент управления для организаций, предоставляющих образовательные продукты и услуги, которые хотят и могут удовлетворить ожидаемые потребности учащихся. При внедрении требований международного стандарта ISO 21001:2018 образовательные организации получают следующие преимущества: повышение эффективности систем управления образовательных учреждений, постоянный контроль на соответствие миссии учреждения и управленческих процессов, удовлетворение потребностей и ожиданий потребителей услуг, применение индивидуального подхода в обучении, расширение возможности для участия заинтересованных сторон, стимулирования по внедрению инноваций.Выводы. Доказано, что основой стандарта ISO 21001:2018 является процессный подход, риск-ориентированное мышление и деятельность, основанная на принципе выполнения задач по схеме: планирование, выполнение, контроль и улучшение деятельности (Plan-Do-Check-Act, или PDCA). Установлено, что все требования ISO 21001:2018 являются общими и предназначены для применения в любом учебном заведении независимо от формы, сроков или способов обучения. Отмечено, что внедрение системы управления в образовательных организациях позволит им продемонстрировать свою способность поддерживать компетенции посредством преподавания, обучения или исследований, а также повысить уровень удовлетворенности потребностей учащихся, персонала и других заинтересованных сторон с помощью эффективного применения механизмов управления и постоянного улучшения своей деятельности., Метою роботи є аналіз вимог та особливостей впровадження ISO 21001:2018 «Освітні організації. Системи управління в освітніх організаціях. Вимоги та настанови щодо застосовування».Результати. У цілому міжнародний стандарт ISO 21001:2018 становить собою інструмент управління для організацій, що надають освітні продукти і послуги, які хочуть і можуть задовольнити очікувані потреби учнів. У разі впровадження вимог міжнародного стандарту ISO 21001:2018 освітні організації отримують такі переваги: підвищення ефективності систем управління освітніх закладів, постійний контроль щодо відповідності місії закладу та управлінських процесів, задоволення потреб та очікувань споживачів послуг, застосування індивідуального підходу в навчанні, розширення можливості для участі зацікавлених сторін, стимулювання впровадження інновацій. Висновки. Доведено, що основою стандарту ISO 21001:2018 є процесний підхід, ризик-орієнтоване мислення та діяльність, що ґрунтується на принципі виконання завдань за схемою: планування, виконання, перевірка і поліпшення заходів (Plan-Do-Check-Act, або PDCA). З’ясовано, що всі вимоги ISO 21001:2018 є загальні й призначені для застосування в будь-якому навчальному закладі незалежно від форми, строків або способів навчання. Визначено, що впровадження системи управління в освітніх організаціях надасть їм змогу продемонструвати свою здатність підтримувати компетенції викладанням, навчанням або дослідженнями, а також дозволить підвищити рівень задоволеності потреб учнів, персоналу та інших зацікавлених сторін за допомогою ефективного застосування відповідних механізмів управління та постійного поліпшення своєї діяльності.

Published
2020

247. Excitation Energies of V<italic>n</italic>O<italic>m</italic>+ and Nb<italic>n</italic>O<italic>m</italic>+ Clusters Sputtered under Ion Bombardment.

Author

Dzhemilev, N. Kh., Kovalenko, S. F., Maksimov, S. E., Tukfatullin, O. F., and Khojiev, Sh. T.

Abstract

The decay of VnOm+ and NbnOm+ clusters sputtered under bombardment of the surfaces of vanadium and niobium with Xe+ ions and oxygen inflow is investigated by secondary-ion mass spectrometry. Based on experimental data, the excitation energy is calculated within the framework of the theory of unimolecular reactions. It is demonstrated that the numerical values of the specific excitation energy of VnOm+ and NbnOm+ within the accuracy of the procedure do not depend significantly on the number of atoms that make up the clusters, nor on their type. [ABSTRACT FROM AUTHOR]

Published
2018
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