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201. Global real-world experiences with pembrolizumab in advanced urothelial carcinoma after platinum-based chemotherapy: the ARON-2 study

Author: Massari, Francesco, Santoni, Matteo, Takeshita, Hideki, Okada, Yohei, Tapia, Jose Carlos, Basso, Umberto, Maruzzo, Marco, Scagliarini, Sarah, Büttner, Thomas, Fornarini, Giuseppe, Myint, Zin W., Galli, Luca, Souza, Vinicius Carrera, Pichler, Renate, De Giorgi, Ugo, Gandur, Nathalia, Lam, Elaine T., Gilbert, Danielle, Popovic, Lazar, Grande, Enrique, Mammone, Giulia, Berardi, Rossana, Crabb, Simon J., Kemp, Robert, Molina-Cerrillo, Javier, Freitas, Marcelo, Luz, Murilo, Iacovelli, Roberto, Calabrò, Fabio, Tural, Deniz, Atzori, Francesco, Küronya, Zsófia, Chiari, Rita, Campos, Saul, Caffo, Orazio, Fay, André P., Kucharz, Jakub, Zucali, Paolo Andrea, Rinck, José Augusto, Zeppellini, Annalisa, Bastos, Diogo Assed, Aurilio, Gaetano, Mota, Augusto, Trindade, Karine, Ortega, Cinzia, Sade, Juan Pablo, Rizzo, Mimma, Fiala, Ondřej, Vau, Nuno, Giannatempo, Patrizia, Barillas, Allan, Monteiro, Fernando Sabino M., Dauster, Breno, Mennitto, Alessia, Nogueira, Lucas, de Carvalho Fernandes, Roni, Seront, Emmanuel, Aceituno, Luís Garcia, Grillone, Francesco, Cutuli, Hernan Javier, Fernandez, Mauricio, Bassanelli, Maria, Kopp, Ray Manneh, Roviello, Giandomenico, Abahssain, Halima, Procopio, Giuseppe, Milella, Michele, Kopecky, Jindrich, Martignetti, Angelo, Messina, Carlo, Caitano, Manuel, Inman, Eva, Kanesvaran, Ravindran, Herchhorn, Daniel, Santini, Daniele, Bamias, Aristotelis, Bisonni, Renato, Mosca, Alessandra, Morelli, Franco, Maluf, Fernando, Soares, Andrey, Nunes, Fernando, Pinto, Alvaro, Zgura, Anca, Incorvaia, Lorena, Ansari, Jawaher, Zabalza, Ignacio Ortego, Landmesser, Johannes, Rizzo, Alessandro, Mollica, Veronica, Marchetti, Andrea, Rosellini, Matteo, Sorgentoni, Giulia, Battelli, Nicola, Buti, Sebastiano, Porta, Camillo, and Bellmunt, Joaquim
Published: 2024
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202. Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Author: Tixi, Wilma, Maldonado, Maricela, Chang, Ya-Ting, Chiu, Amy, Yeung, Wilson, Parveen, Nazia, Nelson, Michael S, Hart, Ryan, Wang, Shihao, Hsu, Wu Jih, Fueger, Patrick, Kopp, Janel L, Huising, Mark O, Dhawan, Sangeeta, and Shih, Hung Ping
Subjects: Biochemistry and Cell Biology, Biological Sciences, Diabetes, Autoimmune Disease, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Metabolic and endocrine, Animals, Cell Adhesion, Integrin beta1, alpha Catenin, Cell Aggregation, Extracellular Matrix, ECM, cell adhesion, developmental biology, endocrine cells, integrin, islet, mouse, α-Catenin, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract: Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels. Cell aggregation is essential for islet endocrine function; however, it remains unclear how developing islets establish aggregation. By combining genetic animal models, imaging tools, and gene expression profiling, we demonstrate that islet aggregation is regulated by extracellular matrix signaling and cell-cell adhesion. Islet endocrine cell-specific inactivation of extracellular matrix receptor integrin β1 disrupted blood vessel interactions but promoted cell-cell adhesion and the formation of larger islets. In contrast, ablation of cell-cell adhesion molecule α-catenin promoted blood vessel interactions yet compromised islet clustering. Simultaneous removal of integrin β1 and α-catenin disrupts islet aggregation and the endocrine cell maturation process, demonstrating that establishment of islet aggregates is essential for functional maturation. Our study provides new insights into understanding the fundamental self-organizing mechanism for islet aggregation, architecture, and functional maturation.
Published: 2023

203. Correction to: Adapting agile development practices for hyper-agile environments: lessons learned from a COVID-19 emergency response research project

Author: Nazir, Salman, Price, Brad, Surendra, Nanda C., and Kopp, Katherine
Published: 2024
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204. Preservice Teachers' Online Self-Regulated Learning: Does Digital Readiness Matter?

Author: Fuchs, Katharina, Pösse, Lisa, Bedenlier, Svenja, Gläser-Zikuda, Michaela, Kammerl, Rudolf, Kopp, Bärbel, Ziegler, Albert, and Händel, Marion
Abstract: (1) Background: Teaching in today's schools asks teachers to foster self-regulated learning and digital competences in children and young people. In order to do so, teachers first need to acquire and use these competences themselves. (2) Methods: Based on a mixed-methods approach, the study investigates self-regulated learning in online courses of N = 129 preservice teachers at a German university. (3) Results and conclusions: Perceiving their digital readiness as generally high, preservice teachers appear to not overly self-regulate their learning in the online environment. Finally, preservice teachers' digital readiness was related only weakly to their online self-regulated learning. A discussion is offered which shows teacher education as a broader phenomenon and implies the need for professional development for teacher educators. Additionally, it is argued to link research on self-regulated learning more closely to research on online learning environments in teacher education.
Published: 2022

205. From Teaching Economics as a Subject to Entrepreneurial Competencies in the Post-Soviet Countries

Author: Kozhabergenova, Aigerim, Pesti, Csilla, and Kopp, Erika
Abstract: Transition from the Soviet type of economy to a new market system showed the necessity in reforms at the secondary school level. Based on a literature review, this paper aims to reveal how the thinking about teaching economics has changed over the past three decades (1991-2021), and how this has affected teaching economics as a school subject in the Post-Soviet countries. The article illustrates these with the cases of Russia and Kazakhstan. For this paper, a narrative literature review methodology was adopted and scanned studies included only those published in English and Russian.
Published: 2022

206. The Role of Practicum in Teacher Education Policy Documents in Ethiopia, Myanmar, Kazakhstan, and Iran

Author: Chaw, Ei Phyu, Kozhabergenova, Aigerim, Beyene, Mestawot Tafese, Saed, Amin, Kopp, Erika, and Rapos, Nora
Abstract: This study aims to compare the role of practicum in teacher education policy documents in Ethiopia, Myanmar, Kazakhstan, and Iran to propose a better way to improve the practicum system The term practicum in pre-service teacher education allows student teachers to integrate their knowledge from the university courses and experiences from the practicing school (Kopp & Kálmán, 2015). The increasing importance of practice in teacher education is a global educational policy trend, but the national context necessarily influences implementation. However, few studies researched comparing teacher education in developing countries, although the national context is essential to understand the organization and operation of teacher education systems (Tatto, 2021) where the main obstacle is the linguistic diversity of different countries. This study referred to Weidman et al. (2014) conceptual framework for comparative and international teacher education. The qualitative document analysis method with MAXQDA software is used to analyze teacher education policy documents, mainly focusing on the aim, structure, and student activities. Researchers developed a common codebook, imported it into the software, and analyzed 39 documents. The results revealed that the aim and definition of the practicum are similar, but the learning outcomes of student teachers' practice related to practicum are a little different between the four countries. Student teachers are required to complete the practicum as part of their preservice teacher education program in four countries. Teacher education policy documents in four countries have addressed all the elements and requirements related to teacher education contexts, however, the implementation level of the practicum in each country may differ significantly. Nevertheless, this study compares the practicum in teacher education document, highlights similarities and differences, and shares the best practices from four countries.
Published: 2022

207. Student Attitudes Contribute to the Effectiveness of a Genomics CURE

Author: Lopatto, David, Rosenwald, Anne G., Burgess, Rebecca C., Silver Key, Catherine, Van Stry, Melanie, Wawersik, Matthew, DiAngelo, Justin R., Hark, Amy T., Skerritt, Matthew, Allen, Anna K., Alvarez, Consuelo, Anderson, Sara, Arrigo, Cindy, Arsham, Andrew, Barnard, Daron, Bedard, James E. J., Bose, Indrani, Braverman, John M., Burg, Martin G., Croonquist, Paula, Du, Chunguang, Dubowsky, Sondra, Eisler, Heather, Escobar, Matthew A., Foulk, Michael, Giarla, Thomas, Glaser, Rivka L., Goodman, Anya L., Gosser, Yuying, Haberman, Adam, Hauser, Charles, Hays, Shan, Howell, Carina E., Jemc, Jennifer, Jones, Christopher J., Kadlec, Lisa, Kagey, Jacob D., Keller, Kimberly L., Kennell, Jennifer, Kleinschmit, Adam J., Kleinschmit, Melissa, Kokan, Nighat P., Kopp, Olga Ruiz, Laakso, Meg M., Leatherman, Judith, Long, Lindsey J., Manier, Mollie, Martinez-Cruzado, Juan C., Matos, Luis F., McClellan, Amie Jo, McNeil, Gerard, Merkhofer, Evan, Mingo, Vida, Mistry, Hemlata, Mitchell, Elizabeth, Mortimer, Nathan T., Myka, Jennifer Leigh, Nagengast, Alexis, Overvoorde, Paul, Paetkau, Don, Paliulis, Leocadia, Parrish, Susan, Toering Peters, Stephanie, Preuss, Mary Lai, Price, James V., Pullen, Nicholas A., Reinke, Catherine, Revie, Dennis, Robic, Srebrenka, Roecklein-Canfield, Jennifer A., Rubin, Michael R., Sadikot, Takrima, Siders Sanford, Jamie, Santisteban, Maria, Saville, Kenneth, Schroeder, Stephanie, Shaffer, Christopher D., Sharif, Karim A., Sklensky, Diane E., Small, Chiyedza, Smith, Sheryl, Spokony, Rebecca, Sreenivasan, Aparna, Stamm, Joyce, Sterne-Marr, Rachel, Teeter, Katherine C., Thackeray, Justin, Thompson, Jeffrey S., Velazquez-Ulloa, Norma, Wolfe, Cindy, Youngblom, James, Yowler, Brian, Zhou, Leming, Brennan, Janie, Buhler, Jeremy, Leung, Wilson, Elgin, Sarah C. R., and Reed, Laura K.
Abstract: The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits. While the GEP CURE produces positive outcomes overall, the students with more positive attitudes toward science, particularly with respect to epistemic beliefs, showed greater gains. The findings indicate the importance of a student's epistemic beliefs to achieving positive learning outcomes.
Published: 2022

208. Colossal magnetoresistance in EuZn$_2$P$_2$ and its electronic and magnetic structure

Author: Krebber, Sarah, Kopp, Marvin, Garg, Charu, Kummer, Kurt, Sichelschmidt, Jörg, Schulz, Susanne, Poelchen, Georg, Mende, Max, Virovets, Alexander V., Warawa, Konstantin, Thomson, Mark D., Tarasov, Artem V., Usachov, Dmitry Yu., Vyalikh, Denis V., Roskos, Hartmut G., Müller, Jens, Krellner, Cornelius, and Kliemt, Kristin
Subjects: Condensed Matter - Strongly Correlated Electrons
Abstract: We investigate single crystals of the trigonal antiferromagnet EuZn$_2$P$_2$ ($P\overline{3}m1$) by means of electrical transport, magnetization measurements, X-ray magnetic scattering, optical reflectivity, angle-resolved photoemission spectroscopy (ARPES) and ab-initio band structure calculations (DFT+U). We find that the electrical resistivity of EuZn$_2$P$_2$ increases strongly upon cooling and can be suppressed in magnetic fields by several orders of magnitude (CMR effect). Resonant magnetic scattering reveals a magnetic ordering vector of $q = (0\, 0\, \frac{1}{2})$, corresponding to an $A$-type antiferromagnetic (AFM) order, below $T_{\rm N} = 23.7\,\rm K$. We find that the moments are canted out of the $a-a$ plane by an angle of about $40^{\circ}\pm 10^{\circ}$ degrees and aligned along the [100] in the $a-a$ plane. We observe nearly isotropic magnetization behavior for low fields and low temperatures which is consistent with the magnetic scattering results. The magnetization measurements show a deviation from the Curie-Weiss behavior below $\approx 150\,\rm K$, the temperature below which also the field dependence of the material's resistivity starts to increase. An analysis of the infrared reflectivity spectrum at $T=295\,\rm K$ allows us to resolve the main phonon bands and intra-/interband transitions, and estimate indirect and direct band gaps of $E_i^{\mathrm{opt}}=0.09\,\rm{eV}$ and $E_d^{\mathrm{opt}}=0.33\,\rm{eV}$, respectively, which are in good agreement with the theoretically predicted ones. The experimental band structure obtained by ARPES is nearly $T$-independent above and below $T_{\rm N}$. The comparison of the theoretical and experimental data shows a weak intermixing of the Eu 4$f$ states close to the $\Gamma$ point with the bands formed by the phosphorous 3$p$ orbitals leading to an induction of a small magnetic moment at the P sites.
Published: 2023
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209. Simulating and reporting frequentist operating characteristics of clinical trials that borrow external information

Author: Kopp-Schneider, Annette, Wiesenfarth, Manuel, Held, Leonhard, and Calderazzo, Silvia
Subjects: Statistics - Methodology
Abstract: Borrowing of information from historical or external data to inform inference in a current trial is an expanding field in the era of precision medicine, where trials are often performed in small patient cohorts for practical or ethical reasons. Many approaches for borrowing from external data have been proposed. Even though these methods are mainly based on Bayesian approaches by incorporating external information into the prior for the current analysis, frequentist operating characteristics of the analysis strategy are of interest. In particular, type I error and power at a prespecified point alternative are in the focus. It is well-known that borrowing from external information may lead to the alteration of type I error rate. We propose a procedure to investigate and report the frequentist operating characteristics in this context. The approach evaluates type I error rate of the test with borrowing from external data and calibrates the test without borrowing to this type I error rate. On this basis, a fair comparison of power between the test with and without borrowing is achieved.
Published: 2023

210. Metropolitan Segment Traffic Speeds from Massive Floating Car Data in 10 Cities

Author: Neun, Moritz, Eichenberger, Christian, Xin, Yanan, Fu, Cheng, Wiedemann, Nina, Martin, Henry, Tomko, Martin, Ambühl, Lukas, Hermes, Luca, and Kopp, Michael
Subjects: Computer Science - Machine Learning
Abstract: Traffic analysis is crucial for urban operations and planning, while the availability of dense urban traffic data beyond loop detectors is still scarce. We present a large-scale floating vehicle dataset of per-street segment traffic information, Metropolitan Segment Traffic Speeds from Massive Floating Car Data in 10 Cities (MeTS-10), available for 10 global cities with a 15-minute resolution for collection periods ranging between 108 and 361 days in 2019-2021 and covering more than 1500 square kilometers per metropolitan area. MeTS-10 features traffic speed information at all street levels from main arterials to local streets for Antwerp, Bangkok, Barcelona, Berlin, Chicago, Istanbul, London, Madrid, Melbourne and Moscow. The dataset leverages the industrial-scale floating vehicle Traffic4cast data with speeds and vehicle counts provided in a privacy-preserving spatio-temporal aggregation. We detail the efficient matching approach mapping the data to the OpenStreetMap road graph. We evaluate the dataset by comparing it with publicly available stationary vehicle detector data (for Berlin, London, and Madrid) and the Uber traffic speed dataset (for Barcelona, Berlin, and London). The comparison highlights the differences across datasets in spatio-temporal coverage and variations in the reported traffic caused by the binning method. MeTS-10 enables novel, city-wide analysis of mobility and traffic patterns for ten major world cities, overcoming current limitations of spatially sparse vehicle detector data. The large spatial and temporal coverage offers an opportunity for joining the MeTS-10 with other datasets, such as traffic surveys in traffic planning studies or vehicle detector data in traffic control settings., Comment: Accepted by IEEE Transactions on Intelligent Transportation Systems (T-ITS), DOI: https://doi.org/10.1109/TITS.2023.3291737
Published: 2023
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211. Bioabsorbable WE43 Mg alloy wires modified by continuous plasma electrolytic oxidation for implant applications. Part II: degradation and biological performance

Author: Ali, Wahaaj, Echeverry-Rendón, Mónica, Dominguez, Guillermo, van Gaalen, Kerstin, Kopp, Alexander, González, Carlos, and LLorca, Javier
Subjects: Condensed Matter - Materials Science
Abstract: The corrosion, mechanical degradation and biological performance of cold-drawn WE43 Mg wires were analyzed as a function of thermo-mechanical processing and the presence of a protective oxide layer created by continuous plasma electrolytic oxidation (PEO). It was found that the corrosion properties of the non-surface-treated wire could be optimized by means of thermal treatment within certain limits, but the corrosion rate remained very high. Hence, strength and ductility of these wires vanished after 24 h of immersion in simulated body fluid at 37$^\circ$C and, as a result of that rather quick degradation, direct tests did not show any MC3T3-E1 preosteoblast cell attachment on the surface of the Mg wires. In contrast, surface modification of the annealed WE43 Mg wires by a continuous PEO process led to the formation of a homogeneous oxide layer of $\approx$ 8$\mu$m and significantly improved the corrosion resistance and hence the biocompatibility of the WE43 Mg wires. It was found that a dense layer of Ca/P was formed at the early stages of degradation on top of the Mg(OH)2 layer and hindered the diffusion of the Cl-ions which dissolve Mg(OH)2 and accelerate the corrosion of Mg alloys. As a result, pitting corrosion was suppressed and the strength of the Mg wires was above 100 MPa after 96 h of immersion in simulated body fluid at 37$^\circ$C. Moreover, many cells were able to attach on the surface of the PEO surface-modified wires during cell culture testing. These results demonstrate the potential of thin Mg wires surface-modified by continuous PEO in terms of mechanical, degradation and biological performance for bioabsorbable wire-based devices.
Published: 2023

212. Understanding metric-related pitfalls in image analysis validation

Author: Reinke, Annika, Tizabi, Minu D., Baumgartner, Michael, Eisenmann, Matthias, Heckmann-Nötzel, Doreen, Kavur, A. Emre, Rädsch, Tim, Sudre, Carole H., Acion, Laura, Antonelli, Michela, Arbel, Tal, Bakas, Spyridon, Benis, Arriel, Blaschko, Matthew, Buettner, Florian, Cardoso, M. Jorge, Cheplygina, Veronika, Chen, Jianxu, Christodoulou, Evangelia, Cimini, Beth A., Collins, Gary S., Farahani, Keyvan, Ferrer, Luciana, Galdran, Adrian, van Ginneken, Bram, Glocker, Ben, Godau, Patrick, Haase, Robert, Hashimoto, Daniel A., Hoffman, Michael M., Huisman, Merel, Isensee, Fabian, Jannin, Pierre, Kahn, Charles E., Kainmueller, Dagmar, Kainz, Bernhard, Karargyris, Alexandros, Karthikesalingam, Alan, Kenngott, Hannes, Kleesiek, Jens, Kofler, Florian, Kooi, Thijs, Kopp-Schneider, Annette, Kozubek, Michal, Kreshuk, Anna, Kurc, Tahsin, Landman, Bennett A., Litjens, Geert, Madani, Amin, Maier-Hein, Klaus, Martel, Anne L., Mattson, Peter, Meijering, Erik, Menze, Bjoern, Moons, Karel G. M., Müller, Henning, Nichyporuk, Brennan, Nickel, Felix, Petersen, Jens, Rafelski, Susanne M., Rajpoot, Nasir, Reyes, Mauricio, Riegler, Michael A., Rieke, Nicola, Saez-Rodriguez, Julio, Sánchez, Clara I., Shetty, Shravya, van Smeden, Maarten, Summers, Ronald M., Taha, Abdel A., Tiulpin, Aleksei, Tsaftaris, Sotirios A., Van Calster, Ben, Varoquaux, Gaël, Wiesenfarth, Manuel, Yaniv, Ziv R., Jäger, Paul F., and Maier-Hein, Lena
Subjects: Computer Science - Computer Vision and Pattern Recognition
Abstract: Validation metrics are key for the reliable tracking of scientific progress and for bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that particularly in image analysis, metrics are often chosen inadequately in relation to the underlying research problem. This could be attributed to a lack of accessibility of metric-related knowledge: While taking into account the individual strengths, weaknesses, and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers. Based on a multi-stage Delphi process conducted by a multidisciplinary expert consortium as well as extensive community feedback, the present work provides the first reliable and comprehensive common point of access to information on pitfalls related to validation metrics in image analysis. Focusing on biomedical image analysis but with the potential of transfer to other fields, the addressed pitfalls generalize across application domains and are categorized according to a newly created, domain-agnostic taxonomy. To facilitate comprehension, illustrations and specific examples accompany each pitfall. As a structured body of information accessible to researchers of all levels of expertise, this work enhances global comprehension of a key topic in image analysis validation., Comment: Shared first authors: Annika Reinke and Minu D. Tizabi; shared senior authors: Lena Maier-Hein and Paul F. J\"ager. Published in Nature Methods. arXiv admin note: text overlap with arXiv:2206.01653
Published: 2023
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213. Spontaneous velocity alignment of Brownian particles with feedback-induced propulsion

Author: Kopp, Robin A. and Klapp, Sabine H. L.
Subjects: Condensed Matter - Soft Condensed Matter
Abstract: Based on Brownian dynamics simulations we study the collective behavior of a twodimensional system of repulsively interacting colloidal particles, where each particle is propelled by a repulsive feedback force with time delay $\tau$. Although the pair interactions are purely isotropic we observe a spontaneous, large-scale alignment of the velocity vectors. This phenomenon persists for long times and occurs in the absence of steady-state clustering. We explain our observations by a combination of the effect of steric interactions yielding local velocity ordering, and the effect of time delay, that generates cluster dissolution, velocity persistence and velocity alignment over large distances. Overall, the behavior reveals intriguing similarities, but also differences, to that observed in models of active matter, such as active Brownian particles and the Vicsek model., Comment: 7 pages, 5 figures
Published: 2023
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214. Bioabsorbable WE43 Mg alloy wires modified by continuous plasma-electrolytic oxidation for implant applications. Part I: processing, microstructure and mechanical properties

Author: Ali, Wahaaj, Li, Muzi, Tillmann, Leon, Mayer, Tim, González, Carlos, LLorca, Javier, and Kopp, Alexander
Subjects: Physics - Medical Physics, Condensed Matter - Materials Science
Abstract: In our work, a novel processing strategy for the continuous fabrication and surface modification of wires from Magnesium alloy WE43 by means of plasma-electrolytic oxidation (PEO) is presented. In the first step, wires with a strong basal texture and small grain size ($\approx$ 1 $\mu$m) were manufactured by combined cold drawing and in-line stress-relief heat treatment steps that optimized the mechanical properties (in terms of strength and ductility) by means of annealing. In a second step, and to the best of our knowledge for the first time ever, the wires were continuously surface-modified with a novel plasma electrolytic oxidation process, which was able to create a homogeneous porous oxide layer made of MgO and Mg$_3$(PO4)$_2$ on the wire surface. While the oxide layer slightly diminished the tensile properties, the strength of the surface-modified wires could be maintained close to 300 MPa with a strain-to-failure $\approx$ 8\%. Furthermore, the thickness of the oxide layer could be controlled by immersion time within the electrolytic bath and was adjusted to realize a thicknesses of $\approx$ 8 $\mu$m, which could be obtained in $<$ 20 s. Our experiments showed that the chemical composition, morphology and porosity of the oxide layer could be tailored by changing electrical parameters. The combined cold drawing and heat treatment process with additional continuous plasma electrolytic oxidation processing can be upscaled to produce a novel generation of bioabsorbable Mg wires with optimized mechanical, degradation and biological performance for use in biomedical applications.
Published: 2023

215. The geometric albedo of the hot Jupiter HD 189733b measured with CHEOPS

Author: Krenn, A. F., Lendl, M., Patel, J. A., Carone, L., Deleuil, M., Sulis, S., Cameron, A. Collier, Deline, A., Guterman, P., Queloz, D., Fossati, L., Brandeker, A., Heng, K., Akinsanmi, B., Adibekyan, V., Bonfanti, A., Demangeon, O. D. S., Kitzmann, D., Salmon, S., Sousa, S. G., Wilson, T. G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Benz, W., Billot, N., Blecha, L., Bonfils, X., Borsato, L., Broeg, C., Cabrera, J., Charnoz, S., van Damme, C. Corral, Csizmadia, Sz., Cubillos, P. E., Davies, M. B., Delrez, L., Demory, B. -O., Ehrenreich, D., Erikson, A., Farinato, J., Fortier, A., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hoyer, S., Isaak, K. G., Kiss, L. L., Kopp, E., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Mordasini, C., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Pallé, E., Peter, G., Piotto, G., Pollacco, D., Ragazzoni, R., Rando, N., Rauer, H., Ribas, I., Santos, N. C., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., Ulmer, B., Van Grootel, V., Venturini, J., and Walton, N. A.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: Context. Measurements of the occultation of an exoplanet at visible wavelengths allow us to determine the reflective properties of a planetary atmosphere. The observed occultation depth can be translated into a geometric albedo. This in turn aids in characterising the structure and composition of an atmosphere by providing additional information on the wavelength-dependent reflective qualities of the aerosols in the atmosphere. Aims. Our aim is to provide a precise measurement of the geometric albedo of the gas giant HD 189733b by measuring the occultation depth in the broad optical bandpass of CHEOPS (350 - 1100 nm). Methods. We analysed 13 observations of the occultation of HD 189733b performed by CHEOPS utilising the Python package PyCHEOPS. The resulting occultation depth is then used to infer the geometric albedo accounting for the contribution of thermal emission from the planet. We also aid the analysis by refining the transit parameters combining observations made by the TESS and CHEOPS space telescopes. Results. We report the detection of an $24.7 \pm 4.5$ ppm occultation in the CHEOPS observations. This occultation depth corresponds to a geometric albedo of $0.076 \pm 0.016$. Our measurement is consistent with models assuming the atmosphere of the planet to be cloud-free at the scattering level and absorption in the CHEOPS band to be dominated by the resonant Na doublet. Taking into account previous optical-light occultation observations obtained with the Hubble Space Telescope, both measurements combined are consistent with a super-stellar Na elemental abundance in the dayside atmosphere of HD 189733b. We further constrain the planetary Bond albedo to between 0.013 and 0.42 at 3$\sigma$ confidence., Comment: 17 pages, 10 figures, accepted for publication in A&A
Published: 2023
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216. Do Inquiring Minds Have Positive Attitudes? The Science Education of Preservice Elementary Teachers

Author: Riegle-Crumb, Catherine, Morton, Karisma, Moore, Chelsea, Chimonidou, Antonia, Labrake, Cynthia, and Kopp, Sacha
Subjects: Physics - Physics Education
Abstract: Owing to their potential impact on students' cognitive and non-cognitive outcomes, the negative attitudes towards science held by many elementary teachers are a critical issue that needs to be addressed. This study focuses on the science education of pre-service elementary teachers with the goal of improving their attitudes before they begin their professional lives as classroom teachers. Specifically, this study builds on a small body of research to examine whether exposure to inquiry-based science content courses that actively involve students in the collaborative process of learning and discovery can promote a positive change in attitudes toward science across several different dimensions. To examine this issue, surveys and administrative data were collected from over 200 students enrolled in the Hands-on-Science (HoS) program for pre-service teachers at the University of Texas at Austin, as well as more than 200 students in a comparison group enrolled in traditional lecture-style classes. Quantitative analyses reveal that after participating in HoS courses, pre-service teachers significantly increased their scores on scales measuring confidence, enjoyment, anxiety, and perceptions of relevance, while those in the comparison group experienced a decline in favorable attitudes to science. These patterns offer empirical support for the attitudinal benefits of inquiry-based instruction and have implications for the future learning opportunities available to students at all education levels.
Published: 2023

217. Microstructuring YbRh2Si2 for resistance and noise measurements down to ultra-low temperatures

Author: Steppke, Alexander, Hamann, Sandra, König, Markus, Mackenzie, Andrew P., Kliemt, Kristin, Krellner, Cornelius, Kopp, Marvin, Lonsky, Martin, Müller, Jens, Levitin, Lev V., Saunders, John, and Brando, Manuel
Subjects: Condensed Matter - Strongly Correlated Electrons
Abstract: The discovery of superconductivity in the quantum critical Kondo-lattice system YbRh2Si2 at an extremely low temperature of 2 mK has inspired efforts to perform high-resolution electrical resistivity measurements down to this temperature range in highly conductive materials. Here we show that control over the sample geometry by microstructuring using focused-ion-beam (FIB) techniques allows to reach ultra-low temperatures and increase signal-to-noise ratios (SNR) tenfold, without adverse effects to sample quality. In five experiments we show four-terminal sensing resistance and magnetoresistance measurements which exhibit sharp phase transitions at the N\'eel temperature, and Shubnikov-de-Haas (SdH) oscillations between 13 T and 18 T where we identified a new SdH frequency of 0.39 kT. The increased SNR allowed resistance fluctuation (noise) spectroscopy that would not be possible for bulk crystals, and confirmed intrinsic 1/f-type fluctuations. Under controlled strain, two thin microstructured samples exhibited a large increase of T_N from 67 mK up to 188 mK while still showing clear signatures of the phase transition and SdH oscillations. SQUID-based thermal noise spectroscopy measurements in a nuclear demagnetisation refrigerator down to 0.95 mK, show a sharp superconducting transition at T_c = 1.2 mK. These experiments demonstrate microstructuring as a powerful tool to investigate the resistance and the noise spectrum of highly conductive correlated metals over wide temperature ranges., Comment: 23 pages, 7 figures
Published: 2023
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218. Re-calibration of the Sunspot Number: Status Report

Author: Clette, F., Lefèvre, L., Chatzistergos, T., Hayakawa, H., Carrasco, V. M., Arlt, R., Cliver, E. W., de Wit, T. Dudok, Friedli, T., Karachik, N., Kopp, G., Lockwood, M., Mathieu, S., Muñoz-Jaramillo, A., Owens, M., Pesnell, D., Pevtsov, A., Svalgaard, L., Usoskin, I. G., van Driel-Gesztelyi, L., and Vaquero, J. M.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: We report progress on the ongoing recalibration of the Wolf sunspot number (SN) and Group sunspot number (GN) following the release of version 2.0 of SN in 2015. This report constitutes both an update of the efforts reported in the 2016 Topical Issue of Solar Physics and a summary of work by the International Space Science Institute (ISSI) International Team formed in 2017 to develop optimal SN and GN re-construction methods while continuing to expand the historical sunspot number database. Significant progress has been made on the database side while more work is needed to bring the various proposed SN and (primarily) GN reconstruction methods closer to maturity, after which the new reconstructions (or combinations thereof) can be compared with (a) ``benchmark'' expectations for any normalization scheme (e.g., a general increase in observer normalization factors going back in time), and (b) independent proxy data series such as F10.7 and the daily range of variations of Earth's undisturbed magnetic field. New versions of the underlying databases for SN and GN will shortly become available for years through 2022 and we anticipate the release of next versions of these two time series in 2024., Comment: 21 figures, 4 tables. To be published in Solar Physics
Published: 2023
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219. Magnetic Moments of Astrophysical Neutrinos

Author: Kopp, Joachim, Opferkuch, Toby, and Wang, Edward
Subjects: High Energy Physics - Phenomenology, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the impact of neutrino magnetic moments on astrophysical neutrinos, in particular supernova neutrinos and ultra-high energy neutrinos from extragalactic sources. We show that magnetic moment-induced conversion of left-handed neutrinos into unobservable right-handed singlet states can substantially change the flux and flavour composition of these neutrinos at Earth. Notably, neutrinos from a supernova's neutronisation burst, whose flux can be predicted with O(10%) accuracy, offer a discovery reach to neutrino magnetic moments $\sim \text{few} \times 10^{-13} \mu_B$, up to one order of magnitude below current limits. For high-energy neutrinos from distant sources, for which no robust flux prediction exists, we show how the flavour composition at Earth can be used as a handle to establish the presence of non-negligible magnetic moments, potentially down to $\text{few} \times 10^{-17} \mu_B$ if the measurement can be performed on neutrinos from a single source. In both cases, the sensitivity strongly depends on the galactic resp. intergalactic magnetic field profiles along the line of sight. Therefore, while a discovery is possible down to very small values of the magnetic moment, the absence of a discovery does not imply an equally strong limit. We also comment on the dependence of our results on the right-handed neutrino mass, paying special attention to the transition from coherent deflection by a classical magnetic field to incoherent scattering on individual scattering targets. Finally, we show that a measurement of Standard Model Dirac neutrino magnetic moments, of order $10^{-19} \mu_B$, could be possible under rather optimistic, but not completely outrageous, assumptions using flavour ratios of high-energy astrophysical neutrinos., Comment: 22 pages, 9 figures, numerical code available from https://github.com/koppj/mm-astro-nu, matches published version in JCAP
Published: 2022
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220. Ray class groups and ray class fields for orders of number fields

Author: Kopp, Gene S. and Lagarias, Jeffrey C.
Subjects: Mathematics - Number Theory, 11R37 (primary), 11R54 (secondary)
Abstract: This paper contributes to the theory of orders of number fields. This paper defines a notion of "ray class group" associated to an arbitrary order in a number field together with an arbitrary ray class modulus for that order (including Archimedean data), constructed using invertible fractional ideals of the order. It shows existence of "ray class fields" corresponding to the class groups. These ray class groups (resp., ray class fields) specialize to classical ray class groups (resp., fields) of a number field in the case of the maximal order, and they specialize to ring class groups (resp., fields) of orders in the case of trivial modulus. The paper gives exact sequences for simultaneous change of order and change of modulus. As a consequence, we identify the ray class field of an order with a given modulus as a specific subfield of a ray class field of the maximal order with a larger modulus. We also uniquely identify each ray class field of an order in terms of the splitting behavior of primes., Comment: 51 pages, 1 figure
Published: 2022

221. Biomedical image analysis competitions: The state of current participation practice

Author: Eisenmann, Matthias, Reinke, Annika, Weru, Vivienn, Tizabi, Minu Dietlinde, Isensee, Fabian, Adler, Tim J., Godau, Patrick, Cheplygina, Veronika, Kozubek, Michal, Ali, Sharib, Gupta, Anubha, Kybic, Jan, Noble, Alison, de Solórzano, Carlos Ortiz, Pachade, Samiksha, Petitjean, Caroline, Sage, Daniel, Wei, Donglai, Wilden, Elizabeth, Alapatt, Deepak, Andrearczyk, Vincent, Baid, Ujjwal, Bakas, Spyridon, Balu, Niranjan, Bano, Sophia, Bawa, Vivek Singh, Bernal, Jorge, Bodenstedt, Sebastian, Casella, Alessandro, Choi, Jinwook, Commowick, Olivier, Daum, Marie, Depeursinge, Adrien, Dorent, Reuben, Egger, Jan, Eichhorn, Hannah, Engelhardt, Sandy, Ganz, Melanie, Girard, Gabriel, Hansen, Lasse, Heinrich, Mattias, Heller, Nicholas, Hering, Alessa, Huaulmé, Arnaud, Kim, Hyunjeong, Landman, Bennett, Li, Hongwei Bran, Li, Jianning, Ma, Jun, Martel, Anne, Martín-Isla, Carlos, Menze, Bjoern, Nwoye, Chinedu Innocent, Oreiller, Valentin, Padoy, Nicolas, Pati, Sarthak, Payette, Kelly, Sudre, Carole, van Wijnen, Kimberlin, Vardazaryan, Armine, Vercauteren, Tom, Wagner, Martin, Wang, Chuanbo, Yap, Moi Hoon, Yu, Zeyun, Yuan, Chun, Zenk, Maximilian, Zia, Aneeq, Zimmerer, David, Bao, Rina, Choi, Chanyeol, Cohen, Andrew, Dzyubachyk, Oleh, Galdran, Adrian, Gan, Tianyuan, Guo, Tianqi, Gupta, Pradyumna, Haithami, Mahmood, Ho, Edward, Jang, Ikbeom, Li, Zhili, Luo, Zhengbo, Lux, Filip, Makrogiannis, Sokratis, Müller, Dominik, Oh, Young-tack, Pang, Subeen, Pape, Constantin, Polat, Gorkem, Reed, Charlotte Rosalie, Ryu, Kanghyun, Scherr, Tim, Thambawita, Vajira, Wang, Haoyu, Wang, Xinliang, Xu, Kele, Yeh, Hung, Yeo, Doyeob, Yuan, Yixuan, Zeng, Yan, Zhao, Xin, Abbing, Julian, Adam, Jannes, Adluru, Nagesh, Agethen, Niklas, Ahmed, Salman, Khalil, Yasmina Al, Alenyà, Mireia, Alhoniemi, Esa, An, Chengyang, Anwar, Talha, Arega, Tewodros Weldebirhan, Avisdris, Netanell, Aydogan, Dogu Baran, Bai, Yingbin, Calisto, Maria Baldeon, Basaran, Berke Doga, Beetz, Marcel, Bian, Cheng, Bian, Hao, Blansit, Kevin, Bloch, Louise, Bohnsack, Robert, Bosticardo, Sara, Breen, Jack, Brudfors, Mikael, Brüngel, Raphael, Cabezas, Mariano, Cacciola, Alberto, Chen, Zhiwei, Chen, Yucong, Chen, Daniel Tianming, Cho, Minjeong, Choi, Min-Kook, Xie, Chuantao Xie Chuantao, Cobzas, Dana, Cohen-Adad, Julien, Acero, Jorge Corral, Das, Sujit Kumar, de Oliveira, Marcela, Deng, Hanqiu, Dong, Guiming, Doorenbos, Lars, Efird, Cory, Escalera, Sergio, Fan, Di, Serj, Mehdi Fatan, Fenneteau, Alexandre, Fidon, Lucas, Filipiak, Patryk, Finzel, René, Freitas, Nuno R., Friedrich, Christoph M., Fulton, Mitchell, Gaida, Finn, Galati, Francesco, Galazis, Christoforos, Gan, Chang Hee, Gao, Zheyao, Gao, Shengbo, Gazda, Matej, Gerats, Beerend, Getty, Neil, Gibicar, Adam, Gifford, Ryan, Gohil, Sajan, Grammatikopoulou, Maria, Grzech, Daniel, Güley, Orhun, Günnemann, Timo, Guo, Chunxu, Guy, Sylvain, Ha, Heonjin, Han, Luyi, Han, Il Song, Hatamizadeh, Ali, He, Tian, Heo, Jimin, Hitziger, Sebastian, Hong, SeulGi, Hong, SeungBum, Huang, Rian, Huang, Ziyan, Huellebrand, Markus, Huschauer, Stephan, Hussain, Mustaffa, Inubushi, Tomoo, Polat, Ece Isik, Jafaritadi, Mojtaba, Jeong, SeongHun, Jian, Bailiang, Jiang, Yuanhong, Jiang, Zhifan, Jin, Yueming, Joshi, Smriti, Kadkhodamohammadi, Abdolrahim, Kamraoui, Reda Abdellah, Kang, Inha, Kang, Junghwa, Karimi, Davood, Khademi, April, Khan, Muhammad Irfan, Khan, Suleiman A., Khantwal, Rishab, Kim, Kwang-Ju, Kline, Timothy, Kondo, Satoshi, Kontio, Elina, Krenzer, Adrian, Kroviakov, Artem, Kuijf, Hugo, Kumar, Satyadwyoom, La Rosa, Francesco, Lad, Abhi, Lee, Doohee, Lee, Minho, Lena, Chiara, Li, Hao, Li, Ling, Li, Xingyu, Liao, Fuyuan, Liao, KuanLun, Oliveira, Arlindo Limede, Lin, Chaonan, Lin, Shan, Linardos, Akis, Linguraru, Marius George, Liu, Han, Liu, Tao, Liu, Di, Liu, Yanling, Lourenço-Silva, João, Lu, Jingpei, Lu, Jiangshan, Luengo, Imanol, Lund, Christina B., Luu, Huan Minh, Lv, Yi, Macar, Uzay, Maechler, Leon, L., Sina Mansour, Marshall, Kenji, Mazher, Moona, McKinley, Richard, Medela, Alfonso, Meissen, Felix, Meng, Mingyuan, Miller, Dylan, Mirjahanmardi, Seyed Hossein, Mishra, Arnab, Mitha, Samir, Mohy-ud-Din, Hassan, Mok, Tony Chi Wing, Murugesan, Gowtham Krishnan, Karthik, Enamundram Naga, Nalawade, Sahil, Nalepa, Jakub, Naser, Mohamed, Nateghi, Ramin, Naveed, Hammad, Nguyen, Quang-Minh, Quoc, Cuong Nguyen, Nichyporuk, Brennan, Oliveira, Bruno, Owen, David, Pal, Jimut Bahan, Pan, Junwen, Pan, Wentao, Pang, Winnie, Park, Bogyu, Pawar, Vivek, Pawar, Kamlesh, Peven, Michael, Philipp, Lena, Pieciak, Tomasz, Plotka, Szymon, Plutat, Marcel, Pourakpour, Fattaneh, Preložnik, Domen, Punithakumar, Kumaradevan, Qayyum, Abdul, Queirós, Sandro, Rahmim, Arman, Razavi, Salar, Ren, Jintao, Rezaei, Mina, Rico, Jonathan Adam, Rieu, ZunHyan, Rink, Markus, Roth, Johannes, Ruiz-Gonzalez, Yusely, Saeed, Numan, Saha, Anindo, Salem, Mostafa, Sanchez-Matilla, Ricardo, Schilling, Kurt, Shao, Wei, Shen, Zhiqiang, Shi, Ruize, Shi, Pengcheng, Sobotka, Daniel, Soulier, Théodore, Fadida, Bella Specktor, Stoyanov, Danail, Mun, Timothy Sum Hon, Sun, Xiaowu, Tao, Rong, Thaler, Franz, Théberge, Antoine, Thielke, Felix, Torres, Helena, Wahid, Kareem A., Wang, Jiacheng, Wang, YiFei, Wang, Wei, Wang, Xiong, Wen, Jianhui, Wen, Ning, Wodzinski, Marek, Wu, Ye, Xia, Fangfang, Xiang, Tianqi, Xiaofei, Chen, Xu, Lizhan, Xue, Tingting, Yang, Yuxuan, Yang, Lin, Yao, Kai, Yao, Huifeng, Yazdani, Amirsaeed, Yip, Michael, Yoo, Hwanseung, Yousefirizi, Fereshteh, Yu, Shunkai, Yu, Lei, Zamora, Jonathan, Zeineldin, Ramy Ashraf, Zeng, Dewen, Zhang, Jianpeng, Zhang, Bokai, Zhang, Jiapeng, Zhang, Fan, Zhang, Huahong, Zhao, Zhongchen, Zhao, Zixuan, Zhao, Jiachen, Zhao, Can, Zheng, Qingshuo, Zhi, Yuheng, Zhou, Ziqi, Zou, Baosheng, Maier-Hein, Klaus, Jäger, Paul F., Kopp-Schneider, Annette, and Maier-Hein, Lena
Subjects: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract: The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.
Published: 2022

222. Tree-based exploratory identification of predictive biomarkers in observational data

Author: Krzykalla, Julia, Benner, Axel, and Kopp-Schneider, Annette
Subjects: Statistics - Methodology
Abstract: The idea of "stratified medicine" is an important driver of methodological research on the identification of predictive biomarkers. Most methods proposed so far for this purpose have been developed for the use on randomized data only. However, especially for rare cancers, data from clinical registries or observational studies might be the only available data source. For such data, methods for an unbiased estimation of the average treatment effect are well established. Research on confounder adjustment when investigating the heterogeneity of treatment effects and the variables responsible for this is usually restricted to regression modelling. In this paper, we demonstrate how the predMOB, a tree-based method that specifically searches for predictive factors, can be combined with common strategies for confounder adjustment (covariate adjustment, matching, Inverse Probability of Treatment Weighting (IPTW)). In an extensive simulation study, we show that covariate adjustment allows the correct identification of predictive factors in the presence of confounding whereas IPTW fails in situations in which the true predictive factor is not completely independent of the confounding mechanism. A combination of both, covariate adjustment and IPTW performs as well as covariate adjustment alone, but might be more robust in complex settings. An application to the German Breast Cancer Study Group (GBSG) Trial 2 illustrates these conclusions.
Published: 2022

223. Von der Evidenz in die Versorgung: Chancen und Risiken für Gesundheits- und Wissenschaftspolitik. Ein Positionspapier der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF)

Author: Wörmann, Bernhard, Kopp, Ina, Nothacker, Monika, Klar, Ernst, Sedlmayr, Martin, Vogeser, Michael, Schliephake, Henning, and Treede, Rolf-Detlef
Subjects: clinical practice guidelines, care delivery, evidence-based medicine, medical device regulation, point-of-care, guideline registries, Medicine
Abstract: Objective: After over 25 years of developing clinical practice guidelines, the Association of the Scientific Medical Societies in Germany (AWMF) held a symposium to discuss the following topics in order to improve the way evidence is implemented in the delivery of care: expansion of the data pool for guideline development, the regulatory policy framework for this expansion, the transfer of clinical practice guideline statements to medical practice, the associated opportunities and risks resulting from the European legislation. Methods: The AWMF held its Berlin Forum on 27 April 2022 where experts from scientific medical societies and national institutions in the healthcare sector reported their experiences and perceptions on the topics mentioned. Three writing groups compiled the key statements from these contributions to and discussions made at the Berlin Forum into a position paper. Results: The AWMF recommends the following:– The creation of a digital infrastructure that serves the quality assurance of clinical practice guidelines and makes their content available at the bedside and during consultations– An increase in the number of industry-independent clinical trials on prevention, diagnostics and therapy with medicinal products, medical devices or other procedures – The funding of registry structures to generate point-of-care healthcare data– The reduction of excessive bureaucratic hurdles at both the national and EU levelConclusions: By making concrete recommendations in this position paper, the AWMF maps out the steps required to improve the translation of evidence to the delivery of clinical care.
Published: 2024
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224. Measurement of the polarizations of prompt and non-prompt Image 1 and ψ(2S) mesons produced in pp collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A.K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F.A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M.A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I.S. Donertas, A. Giammanco, A.O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T.T. Tran, S. Wertz, G.A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W.L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S.J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A.A. Ruales Barbosa, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Carrera Jarrin, Y. Assran, B. El-mahdy, S. Elgammal, M.A. Mahmoud, Y. Mohammed, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, N. Bin Norjoharuddeen, E. Brücken, F. Garcia, P. Inkaew, K.T.S. Kallonen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, M. Kumar, V. Lohezic, J. Malcles, F. Orlandi, L. Portales, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, F. Beaudette, G. Boldrini, P. Busson, A. Cappati, C. Charlot, M. Chiusi, F. Damas, O. Davignon, A. De Wit, I.T. Ehle, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, M. Nguyen, C. Ochando, R. Salerno, J.B. Sauvan, Y. Sirois, L. Urda Gómez, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, R. Haeberle, A.-C. Le Bihan, M. Meena, O. Poncet, G. Saha, M.A. Sessini, P. Van Hove, P. Vaucelle, A. Di Florio, D. Amram, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, E. Jourd‘huy, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, A. Khvedelidze, I. Lomidze, Z. Tsamalaidze, V. Botta, S. Consuegra Rodríguez, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, D. Pérez Adán, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, J. Bach, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, V. Guglielmi, M. Guthoff, A. Hinzmann, L. Jeppe, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, F. Lorkowski, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A.B. Meyer, G. Milella, K. Moral Figueroa, A. Mussgiller, L.P. Nair, J. Niedziela, A. Nürnberg, Y. Otarid, J. Park, E. Ranken, A. Raspereza, D. Rastorguev, J. Rübenach, L. Rygaard, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, S. Bollweg, M. Bonanomi, P. Connor, K. El Morabit, Y. Fischer, E. Garutti, A. Grohsjean, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, C.c. Kuo, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. 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Hiltbrand, B. McMaster, J. Samudio, S. Sawant, C. Sutantawibul, J. Wilson, R. Bartek, A. Dominguez, C. Huerta Escamilla, A.E. Simsek, R. Uniyal, A.M. Vargas Hernandez, B. Bam, A. Buchot Perraguin, R. Chudasama, S.I. Cooper, C. Crovella, S.V. Gleyzer, E. Pearson, C.U. Perez, P. Rumerio, E. Usai, R. Yi, A. Akpinar, C. Cosby, G. De Castro, Z. Demiragli, C. Erice, C. Fangmeier, C. Fernandez Madrazo, E. Fontanesi, D. Gastler, F. Golf, S. Jeon, J. O‘cain, I. Reed, J. Rohlf, K. Salyer, D. Sperka, D. Spitzbart, I. Suarez, A. Tsatsos, A.G. Zecchinelli, G. Benelli, D. Cutts, L. Gouskos, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, S. Mondal, M. Narain, N. Pervan, T. Russell, S. Sagir, F. Simpson, M. Stamenkovic, N. Venkatasubramanian, X. Yan, S. Abbott, C. Brainerd, R. Breedon, H. Cai, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, S. Ostrom, W. Wei, Y. Yao, S. Yoo, F. Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, W. Si, A. Aportela, A. Arora, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, Y. Gu, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, K. Downham, C. Grieco, J. Incandela, A.J. Li, P. Masterson, H. Mei, J. Richman, S.N. Santpur, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T.Á. Vámi, S. Wang, D. Zhang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, G. Reales Gutiérrez, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, T.A. Gómez Espinosa, A. Harilal, A. Kallil Tharayil, C. Liu, T. Mudholkar, S. Murthy, P. Palit, K. Park, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hart, A. Hassani, G. Karathanasis, N. Manganelli, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, D. Zuolo, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, M. Safdari, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, S. Rosenzweig, Y. Takahashi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, M. Wulansatiti, R. Yohay, B. Alsufyani, M.M. Baarmand, S. Butalla, S. Das, T. Elkafrawy, M. Hohlmann, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, M. Hawksworth, A. Hingrajiya, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, E. Prifti, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, M.A. Wadud, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, S. Arteaga Escatel, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, J. Marquez, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, R. Gujju Gurunadha, A. Ivanov, K. Kaadze, Y. Maravin, J. Natoli, D. Roy, G. Sorrentino, A. Baden, A. Belloni, J. Bistany-riebman, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, B. Kronheim, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, I.A. Cali, P.c. Chou, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mcginn, A. Novak, C. Paus, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, R. Rusack, R. Saradhy, N. Strobbe, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, H.w. Hsia, I. Iashvili, A. Kalogeropoulos, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, P. Young, G. Alverson, E. Barberis, J. Bonilla, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, D. Wood, J. Bueghly, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, S. Malik, A.S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A.W. Jung, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, J. Lin, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, B. Chiarito, J.P. Chou, S.V. Clark, D. Gadkari, Y. Gershtein, E. Halkiadakis, M. Heindl, C. Houghton, D. Jaroslawski, S. Konstantinou, I. Laflotte, A. Lath, R. Montalvo, K. Nash, J. Reichert, H. Routray, P. Saha, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, T. Akhter, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, N. Gogate, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, L. Pétré, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Alexakhin, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Quarkonium production, Quarkonium polarization, Physics, QC1-999
Abstract: The polarizations of prompt and non-prompt Image 2 and ψ(2S) mesons are measured in proton-proton collisions at s=13 TeV, using data samples collected by the CMS experiment in 2017 and 2018, corresponding to a total integrated luminosity of 103.3fb−1. Based on the analysis of the dimuon decay angular distributions in the helicity frame, the polar anisotropy, λϑ, is measured as a function of the transverse momentum, pT, of the charmonium states, in the 25–120 and 20–100 GeV ranges for the Image 2 and ψ(2S), respectively. The non-prompt polarizations agree with predictions based on the hypothesis that, for pT≳25GeV, the non-prompt Image 2 and ψ(2S) are predominantly produced in two-body B meson decays. The prompt results clearly exclude strong transverse polarizations, even for pT exceeding 30 times the Image 2 mass, where λϑ tends to an asymptotic value around 0.3. Taken together with previous measurements, by CMS and LHCb at s=7 TeV, the prompt polarizations show a significant variation with pT, at low pT.
Published: 2024
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225. Breast and endometrial safety of micronised progesterone versus norethisterone acetate in menopausal hormone therapy (PROBES): study protocol of a double-blind randomised controlled trial

Author: Angelica Lindén Hirschberg, Stavros I Iliadis, Alkistis Skalkidou, Ina Schuppe-Koistinen, Dorina Ujvari, Christina Lundell, Nikolaos Stergiopoulos, Liselott Blomberg, and Helena Kopp-Kallner
Subjects: Medicine
Abstract: Introduction Data suggest that micronised progesterone (mP) in menopausal hormone therapy is safer for the breast than synthetic progestins, while protection of the endometrium appears to be less effective. However, comparative randomised trial data are lacking. The objective of the Progesterone Breast Endometrial Safety Study is to investigate breast and endometrial safety of mP versus norethisterone acetate (NETA) in continuous combination with oral oestrogen.Methods and analysis This multicentre trial, conducted at three University Hospitals in Stockholm and Uppsala, Sweden, consists of two phases: part 1 focuses on breast safety and is designed as a double-blind, randomised controlled trial. 260 postmenopausal women will be randomised to 100 mg mP or 0.5 mg NETA per day in continuous combination with 1 mg oestradiol. The primary objective is to compare the treatments with respect to percentage change in mammographic breast density after 12-month treatment. Secondary outcomes are breast proliferation, endometrial histology and proliferation, bleeding pattern, gut and vaginal microbiome, hormone levels and coagulation and metabolic factors, mood, and health-related quality of life. Part 2 features an open, single-arm design to study endometrial safety of 1-year treatment with mP in continuous combination with oestradiol on endometrial pathology (hyperplasia and cancer). We will treat 260 additional women with 100 mg mP/1 mg oestradiol resulting in an endometrial safety population of 390 women. The total number of participants in part 1 and part 2 will be 520.Ethics and dissemination The study protocol was approved by the Swedish Ethical Review Authority (2021-03033) on 29 June 2021 with amendment (2023-01480-02, protocol version 3.1) on 14 March 2023. Results of the study will be published in peer-reviewed journals and presented at scientific meetings.Trial registration number NCT05586724.
Published: 2024
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226. Hand-grip strength in recreational downhill skiers: a comparison to normative reference values

Author: Johannes Burtscher, Barbara Strasser, Gerhard Ruedl, Elena Pocecco, Verena Menz, Marc Philippe, Martin Kopp, and Martin Burtscher
Subjects: Downhill skiing, muscle strength, aging, sex, Medicine, Human anatomy, QM1-695
Abstract: Hand-grip strength was evaluated in 757 recreational downhill skiers and compared to 1021 community-dwellers. Findings are reported for age and sex categories consistent with community-dwelling norms. Effect size (Cohen's d) was calculated to estimate the clinical relevance of strength differences between populations. Most male and half of the female age categories of downhill skiers demonstrated higher grip strength of the dominant hand (moderate to large effect size) compared to the reference population. Hand-grip strength in skiers declined with age at a similar rate as in the reference population. Relative grip strength (per kg body mass) was significantly and positively correlated with physical activity (hours/week), and with the number of ski days per year, and negatively with body mass. Thus, hand-grip strength may be related to the type, volume and intensity of exercise regularly performed. These results can help to assess whether the individual hand-grip strength is above or below average with regard to the normal population and the skier population as well and will support advice for training and/or rehabilitation.
Published: 2024
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227. Towards harmonized laboratory methodologies in veterinary clinical bacteriology: outcomes of a European survey

Author: Tom Koritnik, Iskra Cvetkovikj, Flavia Zendri, Shlomo Eduardo Blum, Serafeim Christos Chaintoutis, Peter A. Kopp, Cassia Hare, Zrinka Štritof, Sonja Kittl, José Gonçalves, Irena Zdovc, Erik Paulshus, Andrea Laconi, David Singleton, Fergus Allerton, Els M. Broens, Peter Damborg, and Dorina Timofte
Subjects: veterinary clinical bacteriology, bacterial culture, bacterial identification, antimicrobial susceptibility testing, harmonization, methodologies, Microbiology, QR1-502
Abstract: IntroductionVeterinary clinical microbiology laboratories play a key role in antimicrobial stewardship, surveillance of antimicrobial resistance and prevention of healthcare associated-infections. However, there is a shortage of international harmonized guidelines covering all steps of veterinary bacterial culture from sample receipt to reporting.MethodsIn order to gain insights, the European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT) designed an online survey focused on the practices and interpretive criteria used for bacterial culture and identification (C&ID), and antimicrobial susceptibility testing (AST) of animal bacterial pathogens.ResultsA total of 241 microbiology laboratories in 34 European countries completed the survey, representing a mixture of academic (37.6%), governmental (27.4%), and private (26.5%) laboratories. The C&ID turnaround varied from 1 to 2 days (77.8%) to 3–5 days (20%), and 6– 8 days (1.6%), with similar timeframes for AST. Individual biochemical tests and analytical profile index (API) biochemical test kits or similar were the most frequent tools used for bacterial identification (77% and 56.2%, respectively), followed by PCR (46.6%) and MALDI-TOF MS (43.3%). For AST, Kirby-Bauer disk diffusion (DD) and minimum inhibitory concentration (MIC) determination were conducted by 43.8% and 32.6% of laboratories, respectively, with a combination of EUCAST and CLSI clinical breakpoints (CBPs) preferred for interpretation of the DD (41.2%) and MIC (47.6%) results. In the absence of specific CBPs, laboratories used human CBPs (53.3%) or veterinary CBPs representing another body site, organism or animal species (51.5%). Importantly, most laboratories (47.9%) only report the qualitative interpretation of the result (S, R, and I). As regards testing for AMR mechanisms, 48.5% and 46.7% of laboratories routinely screened isolates for methicillin resistance and ESBL production, respectively. Notably, selective reporting of AST results (i.e. excluding highest priority critically important antimicrobials from AST reports) was adopted by 39.5% of laboratories despite a similar proportion not taking any approach (37.6%) to guide clinicians towards narrower-spectrum or first-line antibiotics.DiscussionIn conclusion, we identified a broad variety of methodologies and interpretative criteria used for C&ID and AST in European veterinary microbiological diagnostic laboratories. The observed gaps in veterinary microbiology practices emphasize a need to improve and harmonize professional training, innovation, bacterial culture methods and interpretation, AMR surveillance and reporting strategies.
Published: 2024
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228. Oral intake of the microalgae Nannochloropsis oceanica, Chlorella vulgaris, or Phaeodactylum tricornutum improves metabolic conditions in hypercaloric-fed mice

Author: Lena Kopp, Benjamin Seethaler, Ulrike Neumann, and Stephan C. Bischoff
Subjects: Microalgae, High-fat diet, Western style diet, Omega-3 fatty acids, Liver, Gut microbiome, Nutrition. Foods and food supply, TX341-641
Abstract: Diet-induced metabolic load is associated with excess body weight and liver steatosis. Here, selected microalgae, known to contain bioactive nutrients, were studied for beneficial metabolic effects in a mouse model of liver steatosis. Adult mice (8 per group) were fed either a Western-style diet (WSD) or a control diet +/− 15 % of the microalgae Chlorella vulgaris (CV), Nannochloropsis oceanica (NO), or Phaeodactylum tricornutum (PT) for 12 weeks. We evaluated liver fat content and liver damage, as well as fecal microbiota and lipopolysaccharide (LPS) translocation. NO supplementation to a WSD reduced the grade of liver steatosis (from 17 % to 4.7 %, p
Published: 2024
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229. Measurement of the production cross section of a Higgs boson with large transverse momentum in its decays to a pair of τ leptons in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M.A. Mahmoud, Y. Mohammed, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, D. Chokheli, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, U. Sarkar, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, A. Mussgiller, L.P. Nair, A. Nürnberg, Y. Otarid, J. Park, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J.M. Lawhorn, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H.J. Simonis, M. Toms, N. Trevisani, R. Ulrich, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, S. Wunsch, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, S. Dutta, P. Palit, S. Sarkar, M.M. Ameen, P.K. Behera, S.C. Behera, P. Jana, P. Kalbhor, J.R. Komaragiri, D. Kumar, L. Panwar, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R.M. Chatterjee, M. Guchait, Sh. Jain, S. Karmakar, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, A.K. Das, C. Kar, D. Maity, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S.K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, B. Kansal, A. Laha, B. Sahu, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D'Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, A. Perrotta, F. Primavera, A.M. Rossi, T. Rovelli, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M.E. Dinardo, P. Dini, S. Gennai, R. Gerosa, A. Ghezzi, P. Govoni, L. Guzzi, M.T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B.S. Pinolini, S. Ragazzi, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A.O.M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, R. Ardino, P. Azzi, N. Bacchetta, D. Bisello, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, T. Dorigo, F. Gasparini, U. Gasparini, E. Lusiani, M. Margoni, A.T. Meneguzzo, M. Migliorini, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, A. Triossi, S. Ventura, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, S. Ajmal, P. Asenov, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, M. Cipriani, V. D'Amante, R. Dell'Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, P. Meridiani, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M.M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, A. Staiano, C. Tarricone, D. Trocino, G. Umoret, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. Huh, B. Kim, D.H. Kim, J. Kim, H. Lee, S.W. Lee, C.S. Moon, Y.D. Oh, M.S. Ryu, S. Sekmen, Y.C. Yang, M.S. Kim, G. Bak, P. Gwak, H. Kim, D.H. Moon, E. Asilar, D. Kim, T.J. Kim, J.A. Merlin, S. Choi, S. Han, B. Hong, K.S. Lee, S. Lee, S.K. Park, J. Yoo, J. Goh, S. Yang, H.S. Kim, Y. Kim, J. Almond, J.H. Bhyun, W. Jun, J.S. Kim, S. Ko, H. Kwon, J. Lee, B.H. Oh, S.B. Oh, H. Seo, U.K. Yang, I. Yoon, W. Jang, D.Y. Kang, Y. Kang, S. Kim, B. Ko, J.S.H. Lee, Y. Lee, I.C. Park, Y. Roh, I.J. Watson, S. Ha, H.D. Yoo, M. Choi, M.R. Kim, I. Yu, T. Beyrouthy, Y. Maghrbi, K. Dreimanis, A. Gaile, G. Pikurs, A. Potrebko, M. Seidel, V. Veckalns, N.R. Strautnieks, M. Ambrozas, A. Juodagalvis, A. Rinkevicius, G. Tamulaitis, N. Bin Norjoharuddeen, I. Yusuff, Z. Zolkapli, J.F. Benitez, A. Castaneda Hernandez, H.A. Encinas Acosta, L.G. Gallegos Maríñez, M. León Coello, J.A. Murillo Quijada, A. Sehrawat, L. Valencia Palomo, G. Ayala, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, C.A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, M. Ramírez García, I. Bautista, I. Pedraza, H.A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P.H. Butler, A. Ahmad, M.I. Asghar, A. Awais, M.I.M. Awan, H.R. Hoorani, W.A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, B. Boimska, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, T. Camporesi, G. Da Molin, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, J.W. Wulff, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, M. Aguilar-Benitez, J. Alcaraz Maestre, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, A. Escalante Del Valle, D. Fernández Del Val, J.P. Fernández Ramos, J. Flix, M.C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J.M. Hernandez, M.I. Josa, D. Moran, C.M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D.D. Redondo Ferrero, L. Romero, S. Sánchez Navas, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J.F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J.R. González Fernández, E. Palencia Cortezon, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, P. Vischia, S. Bhowmik, S. Blanco Fernández, J.A. 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Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, I. Azhgirey, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, M. Chadeeva, V. Chekhovsky, R. Chistov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, R. Ryutin, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Higgs boson, Tau lepton, Physics, QC1-999
Abstract: A measurement of the production cross section of a Higgs boson with transverse momentum greater than 250GeV is presented where the Higgs boson decays to a pair of τ leptons. It is based on proton-proton collision data collected by the CMS experiment at the CERN LHC at a center-of-mass energy of 13TeV. The data sample corresponds to an integrated luminosity of 138fb−1. Because of the large transverse momentum of the Higgs boson the τ leptons from its decays are boosted and produced spatially close, with their decay products overlapping. Therefore, a dedicated algorithm was developed to reconstruct and identify them. The observed (expected) significance of the measured signal with respect to the standard model background-only hypothesis is 3.5 (2.2) standard deviations. The product of the production cross section and branching fraction is measured to be 1.64−0.54+0.68 times the standard model expectation. The fiducial differential production cross section is also measured as functions of the Higgs boson and leading jet transverse momenta. This measurement extends the probed large-transverse-momentum region in the ττ final state beyond 600GeV.
Published: 2024
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230. KS0 and Λ(Λ‾) two-particle femtoscopic correlations in PbPb collisions at sNN=5.02TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, M.A. Mahmoud, Y. Mohammed, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, M.S. Kim, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, M. Lotti, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, T. Tuuva, C. Amendola, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, B. Diab, G. Falmagne, B.A. Fontana Santos Alves, S. Ghosh, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, U. Sarkar, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, G. Bourgatte, J.-M. Brom, E.C. Chabert, C. Collard, D. Darej, U. Goerlach, C. Grimault, A.-C. Le Bihan, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, L. Torterotot, M. Vander Donckt, P. Verdier, S. Viret, I. Bagaturia, I. Lomidze, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, M. Erdmann, P. Fackeldey, D. Fasanella, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, M.y. Lee, L. Mastrolorenzo, M. Merschmeyer, A. Meyer, S. Mondal, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, H. Reithler, A. Schmidt, S.C. Schuler, A. Sharma, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, O. Hlushchenko, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, P. Asmuss, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, S. Bhattacharya, F. Blekman, K. Borras, D. Brunner, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, A. Grohsjean, V. Guglielmi, M. Guthoff, A. Jafari, N.Z. Jomhari, B. Kaech, M. Kasemann, H. Kaveh, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, J. Metwally, A.B. Meyer, G. Milella, M. Mormile, A. Mussgiller, A. Nürnberg, Y. Otarid, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Savitskyi, M. Scham, V. Scheurer, S. Schnake, P. Schütze, C. Schwanenberger, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, N. Tonon, M. Van De Klundert, F. Vazzoler, A. Ventura Barroso, R. Walsh, D. Walter, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, S. Wuchterl, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, K. De Leo, M. Eich, K. El Morabit, F. Feindt, A. Fröhlich, C. Garbers, E. Garutti, M. Hajheidari, J. Haller, A. Hinzmann, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, M. Rieger, O. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, J.O. Gosewisch, A. Gottmann, F. Hartmann, M. Horzela, U. Husemann, M. Klute, R. Koppenhöfer, M. Link, A. Lintuluoto, S. Maier, S. Mitra, Th. Müller, M. Neukum, M. Oh, G. Quast, K. Rabbertz, J. Rauser, I. Shvetsov, H.J. Simonis, N. Trevisani, R. Ulrich, J. van der Linden, R.F. Von Cube, M. Wassmer, S. Wieland, R. Wolf, S. Wozniewski, S. Wunsch, X. Zuo, G. Anagnostou, P. Assiouras, G. Daskalakis, A. Kyriakis, A. Stakia, M. Diamantopoulou, D. Karasavvas, P. Kontaxakis, A. Manousakis-Katsikakis, A. Panagiotou, I. Papavergou, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, P. Gianneios, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, G. Bencze, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, S. Lökös, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, O. Surányi, G.I. Veres, N. Beni, S. Czellar, J. Karancsi, J. Molnar, Z. Szillasi, D. Teyssier, P. Raics, B. Ujvari, G. Zilizi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, R. Gupta, A. Kaur, H. Kaur, M. Kaur, S. Kumar, P. Kumari, M. Meena, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A.K. Virdi, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, D. Bhowmik, S. Dutta, B. Gomber, M. Maity, P. Palit, G. Saha, B. Sahu, S. Sarkar, P.K. Behera, S.C. Behera, P. Kalbhor, J.R. Komaragiri, D. Kumar, A. Muhammad, L. Panwar, R. Pradhan, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, K. Naskar, T. Aziz, I. Das, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, S. Banerjee, M. Guchait, S. Karmakar, G. Majumder, K. Mazumdar, A. Thachayath, S. Bahinipati, A.K. Das, C. Kar, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, A. Nayak, P. Saha, S.K. Swain, D. Vats, A. Alpana, S. Dube, B. Kansal, A. Laha, S. Pandey, A. Rastogi, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, C. Aruta, A. Colaleo, D. Creanza, L. Cristella, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, F. Errico, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, D. Ramos, A. Ranieri, G. Selvaggi, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, A. Perrotta, F. Primavera, A.M. Rossi, T. Rovelli, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, M. Bozzo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M.E. Dinardo, P. Dini, S. Gennai, A. Ghezzi, P. Govoni, L. Guzzi, M.T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B.S. Pinolini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A.O.M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, P. Azzi, N. Bacchetta, M. Biasotto, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, S. Fantinel, F. Gasparini, U. Gasparini, G. Grosso, L. Layer, E. Lusiani, M. Margoni, A.T. Meneguzzo, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, P. Asenov, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Piccinelli, M. Presilla, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Azzurri, G. Bagliesi, V. Bertacchi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, V. D'Amante, R. Dell'Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, S. Parolia, G. Ramirez-Sanchez, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, D. Del Re, E. Di Marco, M. Diemoz, E. Longo, P. Meridiani, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, R. Tramontano, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, M. Grippo, B. Kiani, F. Legger, C. Mariotti, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M.M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, K. Shchelina, F. Siviero, V. Sola, A. Solano, D. Soldi, A. Staiano, M. Tornago, D. Trocino, G. Umoret, A. Vagnerini, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, G. Della Ricca, G. Sorrentino, S. Dogra, C. Huh, B. Kim, D.H. Kim, G.N. Kim, J. Kim, J. Lee, S.W. Lee, C.S. Moon, Y.D. Oh, S.I. Pak, M.S. Ryu, S. Sekmen, Y.C. Yang, H. Kim, D.H. Moon, E. Asilar, T.J. Kim, J. Park, S. Choi, S. Han, B. Hong, K.S. Lee, J. Lim, S.K. Park, J. Yoo, J. Goh, H.S. Kim, Y. Kim, S. Lee, J. Almond, J.H. Bhyun, S. Jeon, J.S. Kim, S. Ko, H. Kwon, H. Lee, B.H. Oh, S.B. Oh, H. Seo, U.K. Yang, I. Yoon, W. Jang, D.Y. Kang, Y. Kang, D. Kim, S. Kim, B. Ko, J.S.H. Lee, Y. Lee, J.A. Merlin, I.C. Park, Y. Roh, D. Song, I.J. Watson, S. Yang, S. Ha, H.D. Yoo, M. 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Boletti, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, M. Pisano, J. Seixas, J. Varela, P. Adzic, M. Dordevic, P. Milenovic, J. Milosevic, M. Aguilar-Benitez, J. Alcaraz Maestre, M. Barrio Luna, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, D. Fernández Del Val, J.P. Fernández Ramos, J. Flix, M.C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J.M. Hernandez, M.I. Josa, J. León Holgado, D. Moran, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D.D. Redondo Ferrero, L. Romero, S. Sánchez Navas, J. Sastre, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J.F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J.R. González Fernández, E. Palencia Cortezon, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, J.A. Brochero Cifuentes, I.J. Cabrillo, A. Calderon, J. Duarte Campderros, M. Fernandez, C. Fernandez Madrazo, A. 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Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K.A. Hahn, Y. Liu, N. Odell, M.H. Schmitt, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, H. Wang, H. Acharya, A.G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, A. Kaminskiy, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korenkov, V. Korotkikh, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, A. Litomin, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, I. Ovtin, V. Palichik, V. Perelygin, S. Petrushanko, V. Popov, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Heavy ion, V0, Femtoscopy, Scattering parameters, Physics, QC1-999
Abstract: Two-particle correlations are presented for KS0, Image 1, and Image 2 strange hadrons as a function of relative momentum in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. The dataset corresponds to an integrated luminosity of 0.607nb−1 and was collected using the CMS detector at the CERN LHC. These correlations are sensitive to quantum statistics and to final-state interactions between the particles. The source size extracted from the KS0KS0 correlations is found to decrease from 4.6 to 1.6fm in going from central to peripheral collisions. Strong interaction scattering parameters (i.e., scattering length and effective range) are determined from the Image 3 and Image 4 (including their charge conjugates) correlations using the Lednický–Lyuboshitz model and are compared to theoretical and other experimental results.
Published: 2024
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231. Searches for violation of Lorentz invariance in top quark pair production using dilepton events in 13 TeV proton-proton collisions

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A.K. Das, G. De Lentdecker, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, A. Lotfy, M.A. Mahmoud, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, K.T.S. Kallonen, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, L. Martikainen, M. Myllymäki, M.m. Rantanen, H. Siikonen, E. Tuominen, J. Tuominiemi, P. Luukka, H. Petrow, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J.L. Faure, F. Ferri, S. Ganjour, P. Gras, G. Hamel de Monchenault, V. Lohezic, J. Malcles, J. Rander, A. Rosowsky, M.Ö. Sahin, A. Savoy-Navarro, P. Simkina, M. Titov, M. Tornago, C. Baldenegro Barrera, F. Beaudette, A. Buchot Perraguin, P. Busson, A. Cappati, C. Charlot, F. Damas, O. Davignon, A. De Wit, B.A. Fontana Santos Alves, S. Ghosh, A. Gilbert, R. Granier de Cassagnac, A. Hakimi, B. Harikrishnan, L. Kalipoliti, G. Liu, J. Motta, M. Nguyen, C. Ochando, L. Portales, R. Salerno, J.B. Sauvan, Y. Sirois, A. Tarabini, E. Vernazza, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Apparu, D. Bloch, J.-M. Brom, E.C. Chabert, C. Collard, S. Falke, U. Goerlach, C. Grimault, R. Haeberle, A.-C. Le Bihan, M. Meena, G. Saha, M.A. Sessini, P. Van Hove, S. Beauceron, B. Blancon, G. Boudoul, A. Carle, N. Chanon, J. Choi, D. Contardo, P. Depasse, C. Dozen, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, C. Greenberg, G. Grenier, B. Ille, I.B. Laktineh, M. Lethuillier, L. Mirabito, S. Perries, A. Purohit, M. Vander Donckt, P. Verdier, J. Xiao, I. Lomidze, T. Toriashvili, Z. Tsamalaidze, V. Botta, L. Feld, K. Klein, M. Lipinski, D. Meuser, A. Pauls, N. Röwert, M. Teroerde, S. Diekmann, A. Dodonova, N. Eich, D. Eliseev, F. Engelke, J. Erdmann, M. Erdmann, P. Fackeldey, B. Fischer, T. Hebbeker, K. Hoepfner, F. Ivone, A. Jung, M.y. Lee, L. Mastrolorenzo, F. Mausolf, M. Merschmeyer, A. Meyer, S. Mukherjee, D. Noll, A. Novak, F. Nowotny, A. Pozdnyakov, Y. Rath, W. Redjeb, F. Rehm, H. Reithler, U. Sarkar, V. Sarkisovi, A. Schmidt, A. Sharma, J.L. Spah, A. Stein, F. Torres Da Silva De Araujo, L. Vigilante, S. Wiedenbeck, S. Zaleski, C. Dziwok, G. Flügge, W. Haj Ahmad, T. Kress, A. Nowack, O. Pooth, A. Stahl, T. Ziemons, A. Zotz, H. Aarup Petersen, M. Aldaya Martin, J. Alimena, S. Amoroso, Y. An, S. Baxter, M. Bayatmakou, H. Becerril Gonzalez, O. Behnke, A. Belvedere, S. Bhattacharya, F. Blekman, K. Borras, A. Campbell, A. Cardini, C. Cheng, F. Colombina, S. Consuegra Rodríguez, G. Correia Silva, M. De Silva, G. Eckerlin, D. Eckstein, L.I. Estevez Banos, O. Filatov, E. Gallo, A. Geiser, A. Giraldi, G. Greau, V. Guglielmi, M. Guthoff, A. Hinzmann, A. Jafari, L. Jeppe, N.Z. Jomhari, B. Kaech, M. Kasemann, C. Kleinwort, R. Kogler, M. Komm, D. Krücker, W. Lange, D. Leyva Pernia, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, M. Mendizabal Morentin, A.B. Meyer, G. Milella, A. Mussgiller, L.P. Nair, A. Nürnberg, Y. Otarid, J. Park, D. Pérez Adán, E. Ranken, A. Raspereza, B. Ribeiro Lopes, J. Rübenach, A. Saggio, M. Scham, S. Schnake, P. Schütze, C. Schwanenberger, D. Selivanova, K. Sharko, M. Shchedrolosiev, R.E. Sosa Ricardo, D. Stafford, F. Vazzoler, A. Ventura Barroso, R. Walsh, Q. Wang, Y. Wen, K. Wichmann, L. Wiens, C. Wissing, Y. Yang, A. Zimermmane Castro Santos, A. Albrecht, S. Albrecht, M. Antonello, S. Bein, L. Benato, M. Bonanomi, P. Connor, M. Eich, K. El Morabit, Y. Fischer, A. Fröhlich, C. Garbers, E. Garutti, A. Grohsjean, M. Hajheidari, J. Haller, H.R. Jabusch, G. Kasieczka, P. Keicher, R. Klanner, W. Korcari, T. Kramer, V. Kutzner, F. Labe, J. Lange, A. Lobanov, C. Matthies, A. Mehta, L. Moureaux, M. Mrowietz, A. Nigamova, Y. Nissan, A. Paasch, K.J. Pena Rodriguez, T. Quadfasel, B. Raciti, M. Rieger, D. Savoiu, J. Schindler, P. Schleper, M. Schröder, J. Schwandt, M. Sommerhalder, H. Stadie, G. Steinbrück, A. Tews, M. Wolf, S. Brommer, M. Burkart, E. Butz, T. Chwalek, A. Dierlamm, A. Droll, N. Faltermann, M. Giffels, A. Gottmann, F. Hartmann, R. Hofsaess, M. Horzela, U. Husemann, J. Kieseler, M. Klute, R. Koppenhöfer, J.M. Lawhorn, M. Link, A. Lintuluoto, S. Maier, S. Mitra, M. Mormile, Th. Müller, M. Neukum, M. Oh, M. Presilla, G. Quast, K. Rabbertz, B. Regnery, N. Shadskiy, I. Shvetsov, H.J. Simonis, M. Toms, N. Trevisani, R. Ulrich, R.F. Von Cube, M. Wassmer, S. Wieland, F. Wittig, R. Wolf, X. Zuo, G. Anagnostou, G. Daskalakis, A. Kyriakis, A. Papadopoulos, A. Stakia, P. Kontaxakis, G. Melachroinos, A. Panagiotou, I. Papavergou, I. Paraskevas, N. Saoulidou, K. Theofilatos, E. Tziaferi, K. Vellidis, I. Zisopoulos, G. Bakas, T. Chatzistavrou, G. Karapostoli, K. Kousouris, I. Papakrivopoulos, E. Siamarkou, G. Tsipolitis, A. Zacharopoulou, K. Adamidis, I. Bestintzanos, I. Evangelou, C. Foudas, C. Kamtsikis, P. Katsoulis, P. Kokkas, P.G. Kosmoglou Kioseoglou, N. Manthos, I. Papadopoulos, J. Strologas, M. Bartók, C. Hajdu, D. Horvath, F. Sikler, V. Veszpremi, M. Csanád, K. Farkas, M.M.A. Gadallah, Á. Kadlecsik, P. Major, K. Mandal, G. Pásztor, A.J. Rádl, G.I. Veres, P. Raics, B. Ujvari, G. Zilizi, G. Bencze, S. Czellar, J. Molnar, Z. Szillasi, T. Csorgo, F. Nemes, T. Novak, J. Babbar, S. Bansal, S.B. Beri, V. Bhatnagar, G. Chaudhary, S. Chauhan, N. Dhingra, A. Kaur, H. Kaur, M. Kaur, S. Kumar, K. Sandeep, T. Sheokand, J.B. Singh, A. Singla, A. Ahmed, A. Bhardwaj, A. Chhetri, B.C. Choudhary, A. Kumar, M. Naimuddin, K. Ranjan, S. Saumya, S. Baradia, S. Barman, S. Dutta, S. Sarkar, M.M. Ameen, P.K. Behera, S.C. Behera, P. Jana, P. Kalbhor, J.R. Komaragiri, D. Kumar, L. Panwar, P.R. Pujahari, N.R. Saha, A.K. Sikdar, S. Verma, S. Dugad, M. Kumar, G.B. Mohanty, P. Suryadevara, A. Bala, S. Banerjee, R.M. Chatterjee, R.K. Dewanjee, M. Guchait, Sh. Jain, S. Karmakar, G. Majumder, K. Mazumdar, S. Parolia, A. Thachayath, S. Bahinipati, C. Kar, D. Maity, P. Mal, T. Mishra, V.K. Muraleedharan Nair Bindhu, K. Naskar, A. Nayak, P. Sadangi, P. Saha, S.K. Swain, S. Varghese, D. Vats, S. Acharya, A. Alpana, S. Dube, B. Gomber, B. Kansal, A. Laha, B. Sahu, S. Sharma, H. Bakhshiansohi, E. Khazaie, M. Zeinali, S. Chenarani, S.M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Grunewald, M. Abbrescia, R. Aly, A. Colaleo, D. Creanza, B. D'Anzi, N. De Filippis, M. De Palma, A. Di Florio, W. Elmetenawee, L. Fiore, G. Iaselli, M. Louka, G. Maggi, M. Maggi, I. Margjeka, V. Mastrapasqua, S. My, S. Nuzzo, A. Pellecchia, A. Pompili, G. Pugliese, R. Radogna, G. Ramirez-Sanchez, D. Ramos, A. Ranieri, L. Silvestris, F.M. Simone, Ü. Sözbilir, A. Stamerra, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, R. Campanini, P. Capiluppi, A. Castro, F.R. Cavallo, M. Cuffiani, G.M. Dallavalle, T. Diotalevi, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, L. Giommi, C. Grandi, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F.L. Navarria, F. Primavera, A.M. Rossi, T. Rovelli, G.P. Siroli, S. Costa, A. Di Mattia, R. Potenza, A. Tricomi, C. Tuve, P. Assiouras, G. Barbagli, G. Bardelli, B. Camaiani, A. Cassese, R. Ceccarelli, V. Ciulli, C. Civinini, R. D'Alessandro, E. Focardi, T. Kello, G. Latino, P. Lenzi, M. Lizzo, M. Meschini, S. Paoletti, A. Papanastassiou, G. Sguazzoni, L. Viliani, L. Benussi, S. Bianco, S. Meola, D. Piccolo, P. Chatagnon, F. Ferro, E. Robutti, S. Tosi, A. Benaglia, G. Boldrini, F. Brivio, F. Cetorelli, F. De Guio, M.E. Dinardo, P. Dini, S. Gennai, R. Gerosa, A. Ghezzi, P. Govoni, L. Guzzi, M.T. Lucchini, M. Malberti, S. Malvezzi, A. Massironi, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, B.S. Pinolini, S. Ragazzi, T. Tabarelli de Fatis, D. Zuolo, S. Buontempo, A. Cagnotta, F. Carnevali, N. Cavallo, A. De Iorio, F. Fabozzi, A.O.M. Iorio, L. Lista, P. Paolucci, B. Rossi, C. Sciacca, R. Ardino, P. Azzi, N. Bacchetta, M. Biasotto, P. Bortignon, A. Bragagnolo, R. Carlin, P. Checchia, T. Dorigo, F. Gasparini, U. Gasparini, E. Lusiani, M. Margoni, F. Marini, A.T. Meneguzzo, M. Migliorini, J. Pazzini, P. Ronchese, R. Rossin, F. Simonetto, G. Strong, M. Tosi, A. Triossi, S. Ventura, H. Yarar, M. Zanetti, P. Zotto, A. Zucchetta, G. Zumerle, S. Abu Zeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, P. Montagna, V. Re, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, S. Ajmal, G.M. Bilei, D. Ciangottini, L. Fanò, M. Magherini, G. Mantovani, V. Mariani, M. Menichelli, F. Moscatelli, A. Rossi, A. Santocchia, D. Spiga, T. Tedeschi, P. Asenov, P. Azzurri, G. Bagliesi, R. Bhattacharya, L. Bianchini, T. Boccali, E. Bossini, D. Bruschini, R. Castaldi, M.A. Ciocci, M. Cipriani, V. D'Amante, R. Dell'Orso, S. Donato, A. Giassi, F. Ligabue, D. Matos Figueiredo, A. Messineo, M. Musich, F. Palla, A. Rizzi, G. Rolandi, S. Roy Chowdhury, T. Sarkar, A. Scribano, P. Spagnolo, R. Tenchini, G. Tonelli, N. Turini, A. Venturi, P.G. Verdini, P. Barria, M. Campana, F. Cavallari, L. Cunqueiro Mendez, D. Del Re, E. Di Marco, M. Diemoz, F. Errico, E. Longo, P. Meridiani, J. Mijuskovic, G. Organtini, F. Pandolfi, R. Paramatti, C. Quaranta, S. Rahatlou, C. Rovelli, F. Santanastasio, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, N. Bartosik, R. Bellan, A. Bellora, C. Biino, C. Borca, N. Cartiglia, M. Costa, R. Covarelli, N. Demaria, L. Finco, M. Grippo, B. Kiani, F. Legger, F. Luongo, C. Mariotti, L. Markovic, S. Maselli, A. Mecca, E. Migliore, M. Monteno, R. Mulargia, M.M. Obertino, G. Ortona, L. Pacher, N. Pastrone, M. Pelliccioni, M. Ruspa, F. Siviero, V. Sola, A. Solano, A. Staiano, C. Tarricone, D. Trocino, G. Umoret, E. Vlasov, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, K. De Leo, G. Della Ricca, S. Dogra, J. Hong, C. Huh, B. Kim, D.H. Kim, J. Kim, H. Lee, S.W. Lee, C.S. Moon, Y.D. Oh, M.S. Ryu, S. Sekmen, Y.C. Yang, M.S. Kim, G. Bak, P. Gwak, H. Kim, D.H. Moon, E. Asilar, D. Kim, T.J. Kim, J.A. Merlin, S. Choi, S. Han, B. Hong, K.S. Lee, S. Lee, S.K. Park, J. Yoo, J. Goh, S. Yang, H.S. Kim, Y. Kim, J. Almond, J.H. Bhyun, W. Jun, S. Ko, H. Kwon, J. Lee, B.H. Oh, S.B. Oh, H. Seo, U.K. Yang, I. Yoon, W. Jang, D.Y. Kang, Y. Kang, S. Kim, B. Ko, J.S.H. Lee, Y. Lee, I.C. Park, Y. Roh, I.J. Watson, S. Ha, H.D. Yoo, M. Choi, M.R. Kim, I. Yu, T. Beyrouthy, Y. Maghrbi, K. Dreimanis, A. Gaile, G. Pikurs, A. Potrebko, M. Seidel, V. Veckalns, N.R. Strautnieks, M. Ambrozas, A. Juodagalvis, A. Rinkevicius, G. Tamulaitis, N. Bin Norjoharuddeen, I. Yusuff, Z. Zolkapli, J.F. Benitez, A. Castaneda Hernandez, H.A. Encinas Acosta, L.G. Gallegos Maríñez, M. León Coello, J.A. Murillo Quijada, A. Sehrawat, L. Valencia Palomo, G. Ayala, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-De La Cruz, R. Lopez-Fernandez, C.A. Mondragon Herrera, A. Sánchez Hernández, C. Oropeza Barrera, M. Ramírez García, I. Bautista, I. Pedraza, H.A. Salazar Ibarguen, C. Uribe Estrada, I. Bubanja, N. Raicevic, P.H. Butler, A. Ahmad, M.I. Asghar, A. Awais, M.I.M. Awan, H.R. Hoorani, W.A. Khan, V. Avati, L. Grzanka, M. Malawski, H. Bialkowska, M. Bluj, B. Boimska, M. Górski, M. Kazana, M. Szleper, P. Zalewski, K. Bunkowski, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, A. Muhammad, K. Pozniak, W. Zabolotny, M. Araujo, D. Bastos, C. Beirão Da Cruz E Silva, A. Boletti, M. Bozzo, T. Camporesi, G. Da Molin, P. Faccioli, M. Gallinaro, J. Hollar, N. Leonardo, T. Niknejad, A. Petrilli, M. Pisano, J. Seixas, J. Varela, J.W. Wulff, P. Adzic, P. Milenovic, M. Dordevic, J. Milosevic, V. Rekovic, M. Aguilar-Benitez, J. Alcaraz Maestre, Cristina F. Bedoya, M. Cepeda, M. Cerrada, N. Colino, B. De La Cruz, A. Delgado Peris, A. Escalante Del Valle, D. Fernández Del Val, J.P. Fernández Ramos, J. Flix, M.C. Fouz, O. Gonzalez Lopez, S. Goy Lopez, J.M. Hernandez, M.I. Josa, D. Moran, C.M. Morcillo Perez, Á. Navarro Tobar, C. Perez Dengra, A. Pérez-Calero Yzquierdo, J. Puerta Pelayo, I. Redondo, D.D. Redondo Ferrero, L. Romero, S. Sánchez Navas, L. Urda Gómez, J. Vazquez Escobar, C. Willmott, J.F. de Trocóniz, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, J.R. González Fernández, E. Palencia Cortezon, C. Ramón Álvarez, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, P. Vischia, S. Bhowmik, S. Blanco Fernández, J.A. Brochero Cifuentes, I.J. Cabrillo, A. Calderon, J. Duarte Campderros, M. Fernandez, G. Gomez, C. Lasaosa García, C. Martinez Rivero, P. Martinez Ruiz del Arbol, F. Matorras, P. Matorras Cuevas, E. Navarrete Ramos, J. Piedra Gomez, L. Scodellaro, I. Vila, J.M. Vizan Garcia, M.K. Jayananda, B. Kailasapathy, D.U.J. Sonnadara, D.D.C. Wickramarathna, W.G.D. Dharmaratna, K. Liyanage, N. Perera, N. Wickramage, D. Abbaneo, C. Amendola, E. Auffray, G. Auzinger, J. Baechler, D. Barney, A. Bermúdez Martínez, M. Bianco, B. Bilin, A.A. Bin Anuar, A. Bocci, C. Botta, E. Brondolin, C. Caillol, G. Cerminara, N. Chernyavskaya, D. d'Enterria, A. Dabrowski, A. David, A. De Roeck, M.M. Defranchis, M. Deile, M. Dobson, L. Forthomme, G. Franzoni, W. Funk, S. Giani, D. Gigi, K. Gill, F. Glege, L. Gouskos, M. Haranko, J. Hegeman, B. Huber, V. Innocente, T. James, P. Janot, S. Laurila, P. Lecoq, E. Leutgeb, C. Lourenço, B. Maier, L. Malgeri, M. Mannelli, A.C. Marini, M. Matthewman, F. Meijers, S. Mersi, E. Meschi, V. Milosevic, F. Monti, F. Moortgat, M. Mulders, I. Neutelings, S. Orfanelli, F. Pantaleo, G. Petrucciani, A. Pfeiffer, M. Pierini, D. Piparo, H. Qu, D. Rabady, G. Reales Gutiérrez, M. Rovere, H. Sakulin, S. Scarfi, C. Schwick, M. Selvaggi, K. Shchelina, P. Silva, P. Sphicas, A.G. Stahl Leiton, A. Steen, S. Summers, D. Treille, P. Tropea, A. Tsirou, D. Walter, J. Wanczyk, S. Wuchterl, P. Zehetner, P. Zejdl, W.D. Zeuner, T. Bevilacqua, L. Caminada, A. Ebrahimi, W. Erdmann, R. Horisberger, Q. Ingram, H.C. Kaestli, D. Kotlinski, C. Lange, M. Missiroli, L. Noehte, T. Rohe, T.K. Aarrestad, K. Androsov, M. Backhaus, A. Calandri, C. Cazzaniga, K. Datta, A. De Cosa, G. Dissertori, M. Dittmar, M. Donegà, F. Eble, M. Galli, K. Gedia, F. Glessgen, C. Grab, D. Hits, W. Lustermann, A.-M. Lyon, R.A. Manzoni, M. Marchegiani, L. Marchese, C. Martin Perez, A. Mascellani, F. Nessi-Tedaldi, F. Pauss, V. Perovic, S. Pigazzini, C. Reissel, T. Reitenspiess, B. Ristic, F. Riti, D. Ruini, R. Seidita, J. Steggemann, D. Valsecchi, R. Wallny, C. Amsler, P. Bärtschi, D. Brzhechko, M.F. Canelli, K. Cormier, J.K. Heikkilä, M. Huwiler, W. Jin, A. Jofrehei, B. Kilminster, S. Leontsinis, S.P. Liechti, A. Macchiolo, P. Meiring, U. Molinatti, A. Reimers, P. Robmann, S. Sanchez Cruz, M. Senger, Y. Takahashi, R. Tramontano, C. Adloff, D. Bhowmik, C.M. Kuo, W. Lin, P.K. Rout, P.C. Tiwari, S.S. Yu, L. Ceard, Y. Chao, K.F. Chen, P.s. Chen, Z.g. Chen, W.-S. Hou, T.h. Hsu, Y.w. Kao, R. Khurana, G. Kole, Y.y. Li, R.-S. Lu, E. Paganis, X.f. Su, J. Thomas-Wilsker, L.s. Tsai, H.y. Wu, E. Yazgan, C. Asawatangtrakuldee, N. Srimanobhas, V. Wachirapusitanand, D. Agyel, F. Boran, Z.S. Demiroglu, F. Dolek, I. Dumanoglu, E. Eskut, Y. Guler, E. Gurpinar Guler, C. Isik, O. Kara, A. Kayis Topaksu, U. Kiminsu, G. Onengut, K. Ozdemir, A. Polatoz, B. Tali, U.G. Tok, S. Turkcapar, E. Uslan, I.S. Zorbakir, M. Yalvac, B. Akgun, I.O. Atakisi, E. Gülmez, M. Kaya, O. Kaya, S. Tekten, A. Cakir, K. Cankocak, Y. 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Li, J. Luo, S. Mondal, M. Narain, N. Pervan, S. Sagir, F. Simpson, M. Stamenkovic, W.Y. Wong, X. Yan, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, M. Citron, J. Conway, P.T. Cox, R. Erbacher, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, W. Wei, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, G. Flores Avila, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, A. Nunez Del Prado, D. Saltzberg, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, A. Barzdukas, L. Brennan, C. Campagnari, A. Dorsett, J. Incandela, A.J. Li, P. Masterson, H. Mei, J. Richman, U. Sarica, R. Schmitz, F. Setti, J. Sheplock, D. Stuart, T.Á. Vámi, S. Wang, A. Bornheim, O. Cerri, A. Latorre, J. Mao, H.B. Newman, M. Spiropulu, J.R. Vlimant, S. Xie, R.Y. Zhu, J. Alison, S. An, M.B. Andrews, P. Bryant, M. Cremonesi, V. Dutta, T. Ferguson, A. Harilal, C. Liu, T. Mudholkar, S. Murthy, P. Palit, M. Paulini, A. Roberts, A. Sanchez, W. Terrill, J.P. Cumalat, W.T. Ford, A. Hassani, G. Karathanasis, E. MacDonald, N. Manganelli, A. Perloff, C. Savard, N. Schonbeck, K. Stenson, K.A. Ulmer, S.R. Wagner, N. Zipper, J. Alexander, S. Bright-Thonney, X. Chen, D.J. Cranshaw, J. Fan, X. Fan, D. Gadkari, S. Hogan, P. Kotamnives, J. Monroy, M. Oshiro, J.R. Patterson, J. Reichert, M. Reid, A. Ryd, J. Thom, P. Wittich, R. Zou, M. Albrow, M. Alyari, O. Amram, G. Apollinari, A. Apresyan, L.A.T. Bauerdick, D. Berry, J. Berryhill, P.C. Bhat, K. Burkett, J.N. Butler, A. Canepa, G.B. Cerati, H.W.K. Cheung, F. Chlebana, G. Cummings, J. Dickinson, I. Dutta, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, A. Grummer, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, C. Aruta, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, K. Mohrman, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, T. Adams, A. Al Kadhim, A. Askew, S. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Beyond standard model, Lorentz symmetry, Physics, QC1-999
Abstract: A search for violation of Lorentz invariance in the production of top quark pairs (tt‾) is presented. The measured normalized differential tt‾ production cross section, as a function of the sidereal time, is examined for potential modulations induced by Lorentz-invariance breaking operators in an effective field theory extension of the standard model (SM). The cross section is measured from collision events collected by the CMS detector at a center-of-mass-energy of 13 TeV, corresponding to an integrated luminosity of 77.8 fb−1, and containing one electron and one muon. The results are found to be compatible with zero, in agreement with the SM, and are used to place upper limits at 68% confidence level on the magnitude of the Lorentz-violating couplings ranging from 1–8×10−3. This is the first precision test of the isotropy in special relativity with top quarks at the LHC, restricting further the bounds on such couplings by up to two orders of magnitude with respect to previous searches conducted at the Tevatron.
Published: 2024
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232. Genomic Landscape in Prostate Cancer in a Latin American Population

Author: Martín Angel, Berenice Freile, Andres Rodriguez, Federico Cayol, Ray Manneh Kopp, Patricia Rioja, Tomas Soule, Federico Losco, Laura Bernal Vaca, Jose Mauricio Penaloza, Maycos Leandro Zapata Muñoz, Silvia Patricia Neciosup, Roger Rodrigo Sanchez, Carolina Passarella, Elvio Guerreño, Diego Farelluk, Ernesto Maturana Leiva, Martin Zarba, Maria Teresa Bourlon, Mauricio Mora Pineda, and Juan Pablo Sade
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: PURPOSEThis study aims to describe genomic characteristics of patients with metastatic prostate cancer (mPC).PATIENTS AND METHODSThis study is a retrospective, multicenter cohort study of patients with mPC and reports on genomic testing. Patients were included from 12 academic centers in five countries.RESULTSA total of 349 patients with PC were included in this study. Most patients (209, 59.9%) were de novo metastatic. Genomic analysis was performed in 233 (66.6%) patients in the metastatic castration-resistant prostate cancer (mCRPC) setting, and only 115 (32.8%) patients had a tumor evaluation in the metastatic hormone sensitive prostate cancer scenario. The evaluation of somatic and/or germline mutations was performed through multigene panel analyses in 290 (83.09%) patients, and next-generation sequencing of BRCA1 and BRCA2 genes was performed in 59 (16.91%) patients. Analyzing the mCRPC subgroup, with a median follow-up of 15.6 months (IQR, 14-19.06), the median progression-free survival (PFS) was not reached (NR) and the PFS at 16 months was 58.7% (95% CI, 50.8 to 67.8). When comparing patients with BRCA mutations with those who are not BRCA-mutated in the mCRPC scenario, the median PFS was NR (95% CI, 14 to NR) and 26.3 months (95% CI, 16.7 to 36.5; P = .2), respectively. Two of six patients with BRCA mutations were treated with targeted therapies (poly-ADP-ribose polymerase inhibitors).CONCLUSIONOur study, to the best of our knowledge, represents one of the larger data sets for somatic testing in patients with PC in Latin America (LATAM). It adds valuable information to the growing body of knowledge about the genomic landscape of advanced PC in real-world daily practice scenarios in LATAM countries, which are not always well-represented in large-scale randomized clinical trials.
Published: 2024
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233. Comparison of a guided assessment and an app-based assessment of physical activity using the Global Physical Activity Questionnaire (GPAQ)

Author: Linda Rausch, Florian Hofstaetter, Nadine Stickel, Martin Kopp, and Martin Widschwendter
Subjects: global physical activity questionnaire, app-based assessment, guided assessment, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: Introduction & Purpose The Global Physical Activity Questionnaire (GPAQ; Armstrong & Bull, 2006) is commonly used to assess frequency, duration and intensity of physical activity (PA) in three domains: work, travel and recreation. It is frequently used as a self-administered questionnaire; however, the execution was originally designed for an interviewer. With the continuous development of app-based technology, the evaluation of PA online-assessment is relevant (Mosa et al., 2012). The objective of the study was to compare an online self-administered version of the GPAQ with the original version administered by an interviewer. Methods The physical activity behaviour of 533 participants (70% female, average age 44, ± 13.9) from the LIFE-Tirol Study (Lasting Health through Intermittent Fasting, Emotional Firmness and Exercise) was assessed by an interviewer using the GPAQ. The interviewer used generic show cards for explaining different levels of exercise intensities as recommended in the analysis guidelines (Armstrong & Bull, 2006). After two months, participants were asked to fill in the GPAQ via online app without show cards. Participant were advised not to change their usual physical activity levels during the two months. The movement domains and intensities of the two versions were compared with Jamovi v2.3 using a series of Wilcoxon W-tests and a series of 2 × 2 mixed ANOVAs to analyse gender- and age-specific aspects. Results Total metabolic equivalent task (MET) minutes were significantly different between interview and self-assessed online version (1,971 ± 2,590 vs. 4,143 ± 4,370 MET minutes; p < .001, d = 0.670). Significantly more MET minutes were reported in the online version compared to the interview version across all three PA-domains and both vigorous and moderate intensities (F(1, 552) = 167, p < .001, ƞ² = .232). This difference was not influenced by gender. 18–34-year-old participants reported significantly less MET minutes during recreational PA than participants older than 55 years in both versions (F(1, 551) = 113, p < .001, ƞ²= .170). No further gender/age × assessment interaction effects were found. Male participants tend to report higher intensity minutes more likely than females in both assessment versions (F(1, 551) = 4.43, p = 0.360, ƞ²= .008). Discussion The amount of PA as well as its intensities seem to differ between the self-assessed online version compared to the interview assessment of the GPAQ, although the interview was conducted as the first measurement and PA as well as intensities were explained in detail to participants using generic show cards. It was previously reported that show cards have no significant impact on the results of the self-administered version of the GPAQ (Rudolf et al., 2020). Therefore, the authors suggest that the main differences between both assessments were caused by the presence of the interviewer independent of age or gender. Conclusion Regardless of the use of show cards and detailed explanations of PA, the main difference between guided and self-administered PA-assessments may result from the presence or absence of an interviewer. Therefore, it is important to interpret self-administered app-based GPAQ evaluations with caution. Future studies should validate app-based GPAQ data by using objective PA measurements, such as accelerometers. References Armstrong, T., & Bull, F. (2006). Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ). Journal of Public Health, 14(2), 66–70. https://doi.org/10.1007/s10389-006-0024-x Mosa, A. S. M., Yoo, I., & Sheets, L. (2012). A systematic review of healthcare applications for smartphones. BMC Medical Informatics and Decision Making, 12, Article 67. https://doi.org/10.1186/1472-6947-12-67 Rudolf, K., Lammer, F., Stassen, G., Froböse, I., & Schaller, A. (2020). Show cards of the Global Physical Activity Questionnaire (GPAQ) – Do they impact validity? A crossover study. BMC Public Health, 20, Article 223. https://doi.org/10.1186/s12889-020-8312-x
Published: 2024
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234. Mountain sport activities, affective state, and mental health – A narrative review

Author: Martin Niedermeier, Benedikt Hösl, Anika Frühauf, and Martin Kopp
Subjects: quality of life, mountain hiking, self-determination theory, self-efficacy hypothesis, skiing, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: A large body of literature indicates that physical activity in general is associated with a variety of health benefits. Mountain sport activities (e.g., mountain hiking, climbing, mountaineering, or skiing) are considered popular modalities of physical activity in both inhabitants of and tourists in mountainous areas. In addition, the majority of mountain sport activities show characteristics that may be favorable for a positive influence on mental health. However, the potential of mountain sport activities on mental health parameters (including, but not limited to affective state, stress, coping abilities, self-efficacy, and quality of life) has been less researched compared to non-mountain sport activities. Therefore, the aims of the present narrative review are to identify characteristics of mountain sport activities related to potential influences on mental health and to summarize current findings on the acute and longer-term effects of sport activities in mountainous areas on affective state and on mental health in general. Furthermore, hypotheses aiming to explain these effects are discussed. Although mountain sport activities show a large diversity in their features, many modalities share characteristics that can be considered relevant in the context of both short-term effects on affective states and of longer-term effects on mental health (Figure 1). Already existing secondary literature focusing specifically on mountain sport activities is limited to one systematic review in the context of mountaineering (Jackman et al., 2020) and one narrative review on health effects of skiing (Burtscher et al., 2019). Original articles for acute effects on affective state and for longer-term effects on mental health parameters were found for mountaineering/alpine climbing, sport climbing, mountain hiking, skiing, and mountain biking. In summary, it can be said that single bouts of mountain sport activities have the potential to positively influence affective state. Observations on negative affective state during the activity are explained by the focus that the participants need to overcome the challenges during the activities. Positive longer-term effects on mental health by mountain sport activity programs are reported in literature. Negative effects on mental health are reported less frequently and occur primarily in the case of accidents or are related to the strenuous experiences during mountaineering expeditions. Potential benefits of mountain sport activities can be explained using approaches related to the physical activity (similar to non-mountain sport activities, e.g., self-efficacy hypothesis) and the environmental conditions in which the activities are practiced (e.g., attention restoration theory). However, the number of studies on hypotheses explaining mental health effects is limited. In addition, not all modalities of mountain sport activities are represented in the literature. In particular, mechanistic considerations of the decisive factors in the various mountain sport activities that can influence mental health would be desirable. References Burtscher, M., Federolf, P. A., Nachbauer, W., & Kopp, M. (2019). Potential health benefits from downhill skiing. Frontiers in Physiology, 9, Article 1924. https://doi.org/10.3389/fphys.2018.01924 Jackman, P. C., Hawkins, R. M., Burke, S. M., Swann, C., & Crust, L. (2020). The psychology of mountaineering: A systematic review. International Review of Sport and Exercise Psychology, 16(1), 27-65. https://doi.org/10.1080/1750984x.2020.1824242
Published: 2024
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235. A study on acute expectation effects on affective state and intention after a brief full-body workout in a student sample

Author: Benedikt Hösl, Julia Straif, Martin Niedermeier, and Martin Kopp
Subjects: physical activity, placebo, expectancy, affective state, intention, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: Introduction & Purpose Research shows that even short exercise programs can have positive effects on affective state (Focht, 2009), which in turn could have a positive influence on the intention to exercise in the future (Finne et al., 2022). The state of research in recent years also indicates that such benefits can be enhanced by manipulating expectations (Helfer et al., 2015). However, most of these studies on expectation effects were conducted in laboratory settings, meaning that the results are transferable to a natural context or everyday situations only to a limited extent. The aim of this study was therefore to examine whether the manipulation of affective expectations can influence affective state after physical activity in a more naturalistic setting; in addition, it was investigated whether the expectation manipulation has an effect on the intention for future exercise. Methods In an online experiment, 121 physically active students (25.58 ± 5.11 years), 70.2% female, were randomly assigned to either a ten-minute, virtually-guided whole-body workout (PA), a ten-minute, virtually-guided whole-body workout after manipulation of affective expectations via audio file (PA + EM), or a sedentary control intervention (CG). In the audio file, a purported speaker for the research team highlighted that recent research indicates that brief workouts would have particularly positive effects on stress experience and affective state. Pre- and post-intervention data, including affective state and intention, were collected using questionnaires, such as the Mood Survey Scales by Abele-Brehm and Brehm (1986). Results After controlling for the baseline level before the intervention via analyses of covariance (ANCOVAs), PA and PA + EM showed significantly more positive scores than CG in several parameters of affective state (e.g., scale Activation, Elation, Fatigue) after the intervention, in some scales (e.g., Affective Valence, Depression) only PA + EM differed significantly from CG. The mean scores in intention after the intervention did not differ significantly between PA + EM (27.00 ± 4.57), PA (27.41 ± 6.79), and CG (27.70 ± 5.78), p = .836. Discussion Even a short, virtually-guided workout can have strong positive effects on affective state. No direct effects of the expectation manipulation on affective state or intention were found. Possible reasons for this include ceiling effects in the participants’ expectations, or that the form of expectation manipulation used was less suitable for influencing the outcomes. However, in some affective parameters, the expectation manipulation was the decisive factor for the differences to the control group, so that more latent effects of the manipulation cannot be ruled out. Conclusion Even though no significant effects of the expectation manipulation were found, the results do not appear to be entirely unaffected by it. Also, because the differences found in affect could have a long-term effect on physical activity behavior, further research is needed in this field in order to be able to make more reliable statements. From a practical perspective, when designing or implementing interventions to increase physically active behavior, practitioners should be aware of the importance of the wording used when describing physical activity to their clients. References Abele-Brehm, A., & Brehm, W. (1986). Zur Konzeptualisierung und Messung von Befindlichkeit: Die Entwicklung der „Befindlichkeitsskalen“ (BFS) [The conceptualization and measurement of mood: The development of the “Mood Survey“]. Diagnostica, 32(3), 209-228. Finne, E., Nigg, C., Weyland, S., Sauzet, O., Wienke, B., & Jekauc, D. (2022). Examining the role of affective states in relation to exercise intentions and participation in extra-curricular exercise classes at university: A repeated measurement observational study. Frontiers in Psychol, 13, Article 815466. https://doi.org/10.3389/fpsyg.2022.815466 Focht, B. C. (2009). Brief walks in outdoor and laboratory environments: Effects on affective responses, enjoyment, and intentions to walk for exercise. Research Quarterly for Exercise and Sport, 80(3), 611-620. https://doi.org/10.1080/02701367.2009.10599600 Helfer, S. G., Elhai, J. D., & Geers, A. L. (2015). Affect and exercise: Positive affective expectations can increase post-exercise mood and exercise intentions. Annals of Behavioral Medicine, 49(2), 269-279. https://doi.org/10.1007/s12160-014-9656-1
Published: 2024
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236. Synergy of exercise and hypoxia for brain health and aging – A narrative review

Author: Johannes Burtscher and Martin Kopp
Subjects: moderate altitude, dementia, exerkines, mitochondria, hypoxic stress, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: Regular exercise is a well-established means to improve brain health and prevent age-related neurological diseases, including dementia (Marques-Aleixo et al., 2020). The precise mechanisms how direct exercise effects are transmitted to the brain remain incompletely understood. However, the increased oxygen demand and associated metabolic stress in the primarily affected tissues – the working skeletal muscle, the cardiovascular and the respiratory system – likely play crucial roles in exercise-signalling to the brain (Severinsen & Pedersen, 2020). Besides the mobilization of beneficial circulating factors, the modulation of blood properties and blood-flow, the immune system and the autonomous system are involved. Intriguingly, physiological stress induced by low environmental oxygen availability (hypoxia) can induce the activation of similar processes like exercise. The aim of this contribution is to evaluate the role of hypoxia in the benefits of exercise on the brain. Accumulating evidence demonstrates the potential of direct modulation of inspired oxygen levels to improve neurological diseases (Burtscher et al., 2021). Reduced all-cause mortality in people living at moderate altitudes (and therefore in chronic, mild hypobaric hypoxia) may also be associated with reduced risk of neurological diseases, including of stroke (Faeh et al., 2009). This is surprising, because the hypoxic stress at moderate altitudes (usually defined as altitudes between 1,500 and 2,500 m) is generally considered too low to induce substantial hypoxia adaptations. It is thus possible that the combination of moderate environmental hypoxia at moderate altitude with the increased oxygen demand during exercise is required to promote protective adaptations, such as of the brain. Considering this possibility, synergistic and complementary molecular and systemic responses and adaptations to exercise and hypoxia may benefit the brain. Among the involved molecular processes are mitochondrial changes following cellular stress that are also linked to the regulation of adaptations by the transcription factor hypoxia inducible factor, which is activated by both hypoxia and exercise. Mitochondria are the main molecular oxygen consumers, respond sensitively to stress and dispose of a wide array of intra- and intercellular communication modes (Memme et al., 2021). Moreover, exerkines, blood-borne factors released in response to exercise, have emerged as important mediators of inter-organ exercise-signalling (Severinsen & Pedersen, 2020) and modulate the autonomic and immune system in response to hypoxic and metabolic stress. In conclusion, the activation of endogenous responses to hypoxic and metabolic stress are powerful means to improve brain health and healthy aging. Based on the overlapping and distinct physiological responses to hypoxia and exercise, brain benefits of exercising at higher altitudes and advances in the development of customized strategies to improve brain resilience are promising approaches to target neurological diseases. While the safe performance of exercise in moderate altitudes is already considered an impactful way to improve brain health, the optimization of combined exercise and (artificially induced) hypoxia for specific target groups requires further in-depth investigation. References Burtscher, J., Mallet, R. T., Burtscher, M., & Millet, G. P. (2021). Hypoxia and brain aging: Neurodegeneration or neuroprotection? Ageing Research Reviews, 68, Article 101343. https://doi.org/10.1016/j.arr.2021.101343 Faeh, D., Gutzwiller, F., Bopp, M., & Group, S. N. C. S. (2009). Lower mortality from coronary heart disease and stroke at higher altitudes in Switzerland. Circulation, 120(6), 495-501. https://doi.org/10.1161/CIRCULATIONAHA.108.819250 Marques-Aleixo, I., Beleza, J., Sampaio, A., Stevanović, J., Coxito, P., Gonçalves, I., Ascensão, A., & Magalhães, J. (2020). Preventive and therapeutic potential of physical exercise in neurodegenerative diseases. Antioxidants & Redox Signaling, 34(8), 674–693. https://doi.org/10.1089/ars.2020.8075 Memme, J. M., Erlich, A. T., Phukan, G., & Hood, D. A. (2021). Exercise and mitochondrial health. The Journal of Physiology, 599(3), 803-817. https://doi.org/10.1113/jp278853 Severinsen, M. C. K., & Pedersen, B. K. (2020). Muscle-organ crosstalk: The emerging roles of myokines. Endocrine Reviews, 41(4), 594-609. https://doi.org/10.1210/endrev/bnaa016
Published: 2024
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237. Effects of 8-weeks of daily time restricted feeding and aerobic exercise on fat oxidation – A randomized controlled trial

Author: Florian Hofstaetter, Linda Rausch, Martin Niedermeier, Martin Kopp, and Justin Lawley
Subjects: fat oxidation, fatmax training, time restricted feeding, intermittent fasting, Sports, GV557-1198.995, Sports medicine, RC1200-1245
Abstract: Introduction & Purpose Substrate metabolism, especially lipid metabolism and thus fat oxidation, is of special interest to reduce the risk of metabolic diseases (diabetes, high cholesterol or triglycerides, etc), and improve athletic performance (Aird et al., 2018). Thus, patients and athletes are recommended to engage in exercise training at a mild to moderate intensity where fat oxidation is high. Fasting is known to increase lipolysis (i.e., fat oxidation) and therefore may represent a simple intervention to increase training induced adaptions in fat oxidation (Venables & Jeukendrup, 2008). However, breaking the fast with a carbohydrate meal prior to aerobic training may limit these benefits because carbohydrate consumption is known to prioritize carbohydrate oxidation during exercise (Achten & Jeukendrup, 2003). Therefore, we tested the hypothesis that 8 weeks of aerobic exercise training at a workload that maximizes fat oxidation would improve the maximal rate of fat oxidation during exercise. Moreover, engaging in a fasting regime would augment the improvements in fat oxidation, but breaking the fast prior to training with a carbohydrate rich snack would attenuate the improvements in fat oxidation. Methods Thirty-six participants (28 females, 8 males) were randomized into three groups. 1) One group fasted for at least 14 hours prior to training, 2) One group fasted, but consumed a carbohydrate rich snack 30 minutes prior to training, 3) One exercise only control group where participants could eat ad libitum. Pre-tests included anthropometric measurements, a bio-impedance-analyses, and cycle ergometry combined with indirect calorimetry to identify maximum rates of fat oxidation (fatmax). All participants exercised on a stationary bike 3x/week for 60 min at a heart rate that corresponded to 90-100% of their individualized fatmax values. Pre-test measurements were repeated after the intervention. Rates of fat and carbohydrate oxidation, energy expenditure and heart rate were analysed as workload matched and absolute data using a series of 3 x 2 mixed ANOVAs. Results 3 x 2 mixed ANOVA showed no group-by-time interactions for any workload-matched data (fatmax: p = 0.371, η²p = 0.058; CHO: p = 0.540, η²p = 0.037; EE: p = 0.470, η²p = 0.045; HR: p = 0.570, η²p = 0.033). No significant group-by-time interactions at the absolute maximal fat oxidation rate were observed (fatmax: p = 0.262, η²p = 0.078; CHO: p = 0.966, η²p = 0.002; EE: p = 0.111, η²p = 0.125; HR: p = 0.618, η²p = 0.029). Discussion and conclusion In the current study, the addition of a 16-hour fasting window did not provide any additional improvements in fat oxidation rates beyond an ad libitum control group. This is surprising as both low-intensity training (Achten & Jeukendrup, 2004) and TRF (Jong-Yeon et al., 2002) have independently been shown to improve fat oxidation. We conclude that fatmax training is an effective lifestyle intervention to improve fat oxidation in young healthy individuals. Collectively, these data suggest fatmax training independent of the fed state might be a useful lifestyle intervention in healthy individuals looking to maintain or improve their metabolic health and avoid future metabolic disease. References Achten, J., & Jeukendrup, A. E. (2003). The effect of pre-exercise carbohydrate feedings on the intensity that elicits maximal fat oxidation. Journal of Sports Sciences, 21(12), 1017–1025. https://doi.org/10.1080/02640410310001641403 Achten, J., & Jeukendrup, A. E. (2004). Optimizing fat oxidation through exercise and diet. Nutrition, 20(7-8), 716–727. https://doi.org/10.1016/j.nut.2004.04.005 Aird, T. P., Davies, R. W., & Carson, B. P. (2018). Effects of fasted vs fed-state exercise on performance and post-exercise metabolism: A systematic review and meta-analysis. Scandinavian Journal of Medicine and Science in Sports, 28(5), 1476–1493. https://doi.org/10.1111/sms.13054 Jong-Yeon, K., Hickner, R. C., Dohm, G. L., & Houmard, J. A. (2002). Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle. Metabolism, 51(4), 460–464. https://doi.org/10.1053/meta.2002.31326 Venables, M. C., & Jeukendrup, A. E. (2008). Endurance training and obesity: Effect on substrate metabolism and insulin sensitivity. Medicine & Science in Sports & Exercise, 40(3), 495–502. https://doi.org/10.1249/MSS.0b013e31815f256f
Published: 2024
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238. Single-cell RNA sequencing data locate ALDH1A2-mediated retinoic acid synthetic pathway to glomerular parietal epithelial cells

Author: Wen-Bin Liu, Damian Fermin, An-Long Xu, Jeffrey B. Kopp, and Qihe Xu
Subjects: Aldh1a2, retinoic acid, scRNA-seq, snRNA-seq, acute kidney injury, chronic kidney disease, Biology (General), QH301-705.5, Medicine
Abstract: Aldehyde dehydrogenase 1, family member A2, is a retinoic acid-synthesizing enzyme encoded by Aldh1a2 in mice and ALDH1A2 in humans. This enzyme is indispensable for kidney development, but its role in kidney physiology and pathophysiology remains to be fully defined. In this review, we mined single-cell and single-nucleus RNA sequencing databases of mouse and human kidneys and found that glomerular parietal epithelial cells (PECs) express a full set of genes encoding proteins needed for cellular vitamin A uptake, intracellular transport, and metabolism into retinoic acid. In particular, Aldh1a2/ALDH1A2 mRNAs are selectively enriched in mouse and human PECs. Aldh1a2 expression in PECs is greatly increased in a mouse model of anti-glomerular basement membrane glomerulonephritis and moderately induced in a mouse model of ischemia-reperfusion acute kidney injury. Aldh1a2 expression in PECs is substantially repressed in a chronic kidney disease mouse model combining diabetes, hypertension, and partial nephrectomy and is moderately repressed in mouse models of focal segmental glomerulosclerosis and diabetic nephropathy. Single-nucleus RNA sequencing data show that ALDH1A2 mRNA expression in PECs is diminished in patients with chronic kidney disease associated with diabetes, hypertension and polycystic kidney disease. In addition to data mining, we also performed Spearman’s rank correlation coefficient analyses and identified gene transcripts correlated with Aldh1a2/ALDH1A2 transcripts in mouse PECs and PEC subtypes, and in human PECs of healthy subjects and patients with AKI or CKD. Furthermore, we conducted Gene Ontology pathway analyses and identified the biological pathways enriched among these Aldh1a2/ALDH1A2-correlated genes. Our data mining and analyses led us to hypothesize that ALDH1A2-mediated retinoic acid synthesis in PECs plays a yet-undefined role in the kidney and that its dysregulation mediates injury. Conditional, PEC-selective Aldh1a2 knockout, RNA silencing and transgenic mouse models will be useful tools to test this hypothesis. Clinical studies on genetics, epigenetics, expression and functions of ALDH1A2 and other genes needed for retinoic acid biosynthesis and signaling are also warranted.
Published: 2024
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239. Multiplex imaging of localized prostate tumors reveals altered spatial organization of AR-positive cells in the microenvironment

Author: Çiğdem Ak, Zeynep Sayar, Guillaume Thibault, Erik A. Burlingame, M.J. Kuykendall, Jennifer Eng, Alex Chitsazan, Koei Chin, Andrew C. Adey, Christopher Boniface, Paul T. Spellman, George V. Thomas, Ryan P. Kopp, Emek Demir, Young Hwan Chang, Vasilis Stavrinides, and Sebnem Ece Eksi
Subjects: Microenvironment, Cancer, Omics, Science
Abstract: Summary: Mapping the spatial interactions of cancer, immune, and stromal cell states presents novel opportunities for patient stratification and for advancing immunotherapy. While single-cell studies revealed significant molecular heterogeneity in prostate cancer cells, the impact of spatial stromal cell heterogeneity remains poorly understood. Here, we used cyclic immunofluorescent imaging on whole-tissue sections to uncover novel spatial associations between cancer and stromal cells in low- and high-grade prostate tumors and tumor-adjacent normal tissues. Our results provide a spatial map of single cells and recurrent cellular neighborhoods in the prostate tumor microenvironment of treatment-naive patients. We report unique populations of mast cells that show distinct spatial associations with M2 macrophages and regulatory T cells. Our results show disease-specific neighborhoods that are primarily driven by androgen receptor-positive (AR+) stromal cells and identify inflammatory gene networks active in AR+ prostate stroma.
Published: 2024
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240. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.

Author: Mastracci, Teresa L, Apte, Minoti, Amundadottir, Laufey T, Alvarsson, Alexandra, Artandi, Steven, Bellin, Melena D, Bernal-Mizrachi, Ernesto, Caicedo, Alejandro, Campbell-Thompson, Martha, Cruz-Monserrate, Zobeida, El Ouaamari, Abdelfattah, Gaulton, Kyle J, Geisz, Andrea, Goodarzi, Mark O, Hara, Manami, Hull-Meichle, Rebecca L, Kleger, Alexander, Klein, Alison P, Kopp, Janel L, Kulkarni, Rohit N, Muzumdar, Mandar D, Naren, Anjaparavanda P, Oakes, Scott A, Olesen, Søren S, Phelps, Edward A, Powers, Alvin C, Stabler, Cherie L, Tirkes, Temel, Whitcomb, David C, Yadav, Dhiraj, Yong, Jing, Zaghloul, Norann A, Pandol, Stephen J, and Sander, Maike
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Rare Diseases, Cancer, Pancreatic Cancer, Diabetes, Metabolic and endocrine, Good Health and Well Being, Humans, Diabetes Mellitus, Islets of Langerhans, Pancreas, Pancreas, Exocrine, Pancreatic Diseases, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences
Abstract: The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine-endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics relevant to each area of research; these are summarized here. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
Published: 2023

241. Robust incorporation of historical information with known type I error rate inflation

Author: Calderazzo, Silvia and Kopp-Schneider, Annette
Subjects: Statistics - Methodology
Abstract: Bayesian clinical trials can benefit of available historical information through the elicitation of informative prior distributions. Concerns are however often raised about the potential for prior-data conflict and the impact of Bayes test decisions on frequentist operating characteristics, with particular attention being assigned to inflation of type I error rates. This motivates the development of principled borrowing mechanisms, that strike a balance between frequentist and Bayesian decisions. Ideally, the trust assigned to historical information defines the degree of robustness to prior-data conflict one is willing to sacrifice. However, such relationship is often not directly available when explicitly considering inflation of type I error rates. We build on available literature relating frequentist and Bayesian test decisions, and investigate a rationale for inflation of type I error rate which explicitly and linearly relates the amount of borrowing and the amount of type I error rate inflation in one-arm studies. A novel dynamic borrowing mechanism tailored to hypothesis testing is additionally proposed. We show that, while dynamic borrowing prevents the possibility to obtain a simple closed form type I error rate computation, an explicit upper bound can still be enforced. Connections with the robust mixture prior approach, particularly in relation to the choice of the mixture weight and robust component, are made. Simulations are performed to show the properties of the approach for normal and binomial outcomes.
Published: 2022

242. Profiling and Improving the PyTorch Dataloader for high-latency Storage: A Technical Report

Author: Svogor, Ivan, Eichenberger, Christian, Spanring, Markus, Neun, Moritz, and Kopp, Michael
Subjects: Computer Science - Machine Learning, Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Performance
Abstract: A growing number of Machine Learning Frameworks recently made Deep Learning accessible to a wider audience of engineers, scientists, and practitioners, by allowing straightforward use of complex neural network architectures and algorithms. However, since deep learning is rapidly evolving, not only through theoretical advancements but also with respect to hardware and software engineering, ML frameworks often lose backward compatibility and introduce technical debt that can lead to bottlenecks and sub-optimal resource utilization. Moreover, the focus is in most cases not on deep learning engineering, but rather on new models and theoretical advancements. In this work, however, we focus on engineering, more specifically on the data loading pipeline in the PyTorch Framework. We designed a series of benchmarks that outline performance issues of certain steps in the data loading process. Our findings show that for classification tasks that involve loading many files, like images, the training wall-time can be significantly improved. With our new, modified ConcurrentDataloader we can reach improvements in GPU utilization and significantly reduce batch loading time, up to 12X. This allows for the use of the cloud-based, S3-like object storage for datasets, and have comparable training time as if datasets are stored on local drives.
Published: 2022

243. More Ingredients for an Altarelli Cocktail at MiniBooNE

Author: Kelly, Kevin J. and Kopp, Joachim
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: The MiniBooNE excess persists as a significant puzzle in particle physics. Given that the MiniBooNE detector cannot discriminate between electron-like signals and backgrounds due to photons, the goal of this work is to study photon backgrounds in MiniBooNE in depth. We first consider a novel single-photon background arising from multi-nucleon scattering with coherently enhanced initial or final state radiation. This class of processes, which we dub "2p2h$\gamma$" (two-particle--two-hole + photon) can explain ${\sim}40$ of the ${\sim}560$ excess events observed by MiniBooNE in neutrino mode. Second, we consider the background from neutral-current single-$\pi^0$ production, where two photons from $\pi^0\to\gamma\gamma$ decay are mis-identified as an electron-like shower. We construct a phenomenological likelihood that reproduces MiniBooNE's $\pi^0\to\gamma\gamma$ background faithfully. Even with data-driven background estimation techniques, we find there is a residual dependence on the Monte Carlo generator used. Our results motivate a reduction in the significance of the MiniBooNE excess by $0.4\sigma$., Comment: v2: revised the discussion of Monte Carlo statistics, with result now in better agreement with MiniBooNE's, and leaving the anomaly largely intact. Matches version accepted by JHEP
Published: 2022
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244. Testing the mean field theory of scalar field dark matter

Author: Eberhardt, Andrew, Zamora, Alvaro, Kopp, Michael, and Abel, Tom
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract: Scalar field dark matter offers an interesting alternative to the traditional WIMP dark matter picture. Astrophysical and cosmological simulations are useful to constraining the mass of the dark matter particle in this model. This is particularly true at low mass where the wavelike nature of the dark matter particle manifests on astrophysical scales. These simulations typical use a classical field approximation. In this work, we look at extending these simulations to include quantum corrections. We look into both the ways in which large corrections impact the predictions of scalar field dark matter, and the timescales on which these corrections grow large. Corrections tend to lessen density fluctuations and increase the effect of "quantum pressure". During collapse, these corrections grow exponentially, quantum corrections would become important in about ~30 dynamical times. This implies that the predictions of classical field simulations may differ from those with quantum corrections for systems with short dynamical times., Comment: IDM conference proceedings
Published: 2022

245. Sketched Multi-view Subspace Learning for Hyperspectral Anomalous Change Detection

Author: Chang, Shizhen, Kopp, Michael, and Ghamisi, Pedram
Subjects: Computer Science - Computer Vision and Pattern Recognition
Abstract: In recent years, multi-view subspace learning has been garnering increasing attention. It aims to capture the inner relationships of the data that are collected from multiple sources by learning a unified representation. In this way, comprehensive information from multiple views is shared and preserved for the generalization processes. As a special branch of temporal series hyperspectral image (HSI) processing, the anomalous change detection task focuses on detecting very small changes among different temporal images. However, when the volume of datasets is very large or the classes are relatively comprehensive, existing methods may fail to find those changes between the scenes, and end up with terrible detection results. In this paper, inspired by the sketched representation and multi-view subspace learning, a sketched multi-view subspace learning (SMSL) model is proposed for HSI anomalous change detection. The proposed model preserves major information from the image pairs and improves computational complexity by using a sketched representation matrix. Furthermore, the differences between scenes are extracted by utilizing the specific regularizer of the self-representation matrices. To evaluate the detection effectiveness of the proposed SMSL model, experiments are conducted on a benchmark hyperspectral remote sensing dataset and a natural hyperspectral dataset, and compared with other state-of-the art approaches.
Published: 2022
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246. Persistent motion of a Brownian particle subject to repulsive feedback with time delay

Author: Kopp, Robin A. and Klapp, Sabine H. L.
Subjects: Condensed Matter - Soft Condensed Matter
Abstract: Based on analytical and numerical calculations we study the dynamics of an overdamped colloidal particle moving in two dimensions under time-delayed, non-linear feedback control. Specifically, the particle is subject to a force derived from a repulsive Gaussian potential depending on the difference between its instantaneous position, $\mathbf{r}(t)$, and its earlier position $\mathbf{r}(t-\tau)$, where $\tau$ is the delay time. Considering first the deterministic case, we provide analytical results for both, the case of small displacements and the dynamics at long times. In particular, at appropriate values of the feedback parameters, the particle approaches a steady state with a constant, non-zero velocity whose direction is constant as well. In the presence of noise, the direction of motion becomes randomized at long times, but the (numerically obtained) velocity autocorrelation still reveals some persistence of motion. Moreover, the mean-squared displacement (MSD) reveals a mixed regime at intermediate times with contributions of both, ballistic motion and diffusive translational motion, allowing us to extract an estimate for the effective propulsion velocity in presence of noise. We then analyze the data in terms of exact, known results for the MSD of active Brownian particles. The comparison indeed indicates a strong similarity between the dynamics of the particle under repulsive delayed feedback and active motion. This relation carries over to the behavior of the long-time diffusion coefficient $D_\mathrm{eff}$ which, similarly to active motion, is strongly enhanced compared to the free case. Finally we show that, for small delays, $D_\mathrm{eff}$ can be estimated analytically., Comment: 16 pages, 10 figures
Published: 2022
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247. Multi-messenger characterization of Mrk 501 during historically low X-ray and $\gamma$-ray activity

Author: MAGIC collaboration, Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., Baxter, J., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Foffano, L., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Grau, R., Green, D., Green, J. G., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., groups, Other, collaborations, Cerruti, M., Acosta-Pulido, J. A., Apolonio, G., Bachev, R., Baloković, M., Benítez, E., Björklund, I., Bozhilov, V., Brown, L. F., Bugg, A., Carbonell, W., Carnerero, M. I., Carosati, D., Casadio, C., Chamani, W., Chen, W. P., Chigladze, R. A., Damljanovic, G., Epps, K., Erkenov, A., Feige, M., Finke, J., Fuentes, A., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Heidemann, E., Hiriart, D., Hou, W. J., Hovatta, T., Ibryamov, S., Joner, M. D., Jorstad, S. G., Kania, J., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Korte, M., Kotas, B., Koyama, S., Kramer, J. A., Kunkel, L., Kurtanidze, S. O., Kurtanidze, O. M., Lähteenmäki, A., López, J. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Leto, C., Lorey, C., Mújica, R., Madejski, G. M., Marchili, N., Marscher, A. P., Minev, M., Modaressi, A., Morozova, D. A., Mufakharov, T., Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Ovcharov, E., Perri, M., Raiteri, C. M., Readhead, A. C. S., Reimer, A., Reinhart, D., Righini, S., Rosenlehner, K., Sadun, A. C., Savchenko, S. S., Scherbantin, A., Schneider, L., Schoch, K., Seifert, D., Semkov, E., Sigua, L. A., Singh, C., Sola, P., Sotnikova, Y., Spencer, M., Steineke, R., Stojanovic, M., Strigachev, A., Tornikoski, M., Traianou, E., Tramacere, A., Troitskaya, Yu. V., Troitskiy, I. S., Trump, J. B., Tsai, A., Valcheva, A., Vasilyev, A. A., Verrecchia, F., Villata, M., Vince, O., Vrontaki, K., Weaver, Z. R., Zaharieva, E., and Zottmann, N.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We study the broadband emission of Mrk 501 using multi-wavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi-LAT, NuSTAR, Swift, GASP-WEBT, and OVRO. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wavebands, with the highest occurring at X-rays and very-high-energy (VHE) $\gamma$-rays. A significant correlation ($>$3$\sigma$) between X-rays and VHE $\gamma$-rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between Swift-XRT and Fermi-LAT. We additionally find correlations between high-energy $\gamma$-rays and radio, with the radio lagging by more than 100 days, placing the $\gamma$-ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE $\gamma$-rays from mid-2017 to mid-2019 with a stable VHE flux ($>$0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2-year-long low-state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED towards the low-state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock., Comment: 55 pages, 30 figures, 14 tables, accepted by APJS. Corresponding authors are L. Heckmann, D. Paneque, S. Gasparyan, M. Cerruti, and N. Sahakyan
Published: 2022
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248. Predicting the Future of AI with AI: High-quality link prediction in an exponentially growing knowledge network

Author: Krenn, Mario, Buffoni, Lorenzo, Coutinho, Bruno, Eppel, Sagi, Foster, Jacob Gates, Gritsevskiy, Andrew, Lee, Harlin, Lu, Yichao, Moutinho, Joao P., Sanjabi, Nima, Sonthalia, Rishi, Tran, Ngoc Mai, Valente, Francisco, Xie, Yangxinyu, Yu, Rose, and Kopp, Michael
Subjects: Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract: A tool that could suggest new personalized research directions and ideas by taking insights from the scientific literature could significantly accelerate the progress of science. A field that might benefit from such an approach is artificial intelligence (AI) research, where the number of scientific publications has been growing exponentially over the last years, making it challenging for human researchers to keep track of the progress. Here, we use AI techniques to predict the future research directions of AI itself. We develop a new graph-based benchmark based on real-world data -- the Science4Cast benchmark, which aims to predict the future state of an evolving semantic network of AI. For that, we use more than 100,000 research papers and build up a knowledge network with more than 64,000 concept nodes. We then present ten diverse methods to tackle this task, ranging from pure statistical to pure learning methods. Surprisingly, the most powerful methods use a carefully curated set of network features, rather than an end-to-end AI approach. It indicates a great potential that can be unleashed for purely ML approaches without human knowledge. Ultimately, better predictions of new future research directions will be a crucial component of more advanced research suggestion tools., Comment: 13 pages, 7 figures. Comments welcome!
Published: 2022
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249. Immersed boundary parametrizations for full waveform inversion

Author: Bürchner, Tim, Kopp, Philipp, Kollmannsberger, Stefan, and Rank, Ernst
Subjects: Computer Science - Computational Engineering, Finance, and Science
Abstract: Full Waveform Inversion (FWI) is a successful and well-established inverse method for reconstructing material models from measured wave signals. In the field of seismic exploration, FWI has proven particularly successful in the reconstruction of smoothly varying material deviations. In contrast, non-destructive testing (NDT) often requires the detection and specification of sharp defects in a specimen. If the contrast between materials is low, FWI can be successfully applied to these problems as well. However, so far the method is not fully suitable to image defects such as voids, which are characterized by a high contrast in the material parameters. In this paper, we introduce a dimensionless scaling function $\gamma$ to model voids in the forward and inverse scalar wave equation problem. Depending on which material parameters this function $\gamma$ scales, different modeling approaches are presented, leading to three formulations of mono-parameter FWI and one formulation of two-parameter FWI. The resulting problems are solved by first-order optimization, where the gradient is computed by an ajdoint state method. The corresponding Fr\'echet kernels are derived for each approach and the associated minimization is performed using an L-BFGS algorithm. A comparison between the different approaches shows that scaling the density with $\gamma$ is most promising for parameterizing voids in the forward and inverse problem. Finally, in order to consider arbitrary complex geometries known a priori, this approach is combined with an immersed boundary method, the finite cell method (FCM)., Comment: 23 pages, 21 figures
Published: 2022
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250. CHEOPS finds KELT-1b darker than expected in visible light: Discrepancy between the CHEOPS and TESS eclipse depths

Author: Parviainen, H., Wilson, T. G., Lendl, M., Kitzmann, D., Pallé, E., Serrano, L. M., Valdes, E. Meier, Benz, W., Deline, A., Ehrenreich, D., Guterman, P., Heng, K., Demangeon, O. D. S., Bonfanti, A., Salmon, S., Singh, V., Santos, N. C., Sousa, S. G., Alibert, Y., Alonso, R., Anglada, G., Bárczy, T., Navascues, D. Barrado y, Barros, S. C. C., Baumjohann, W., Beck, M., Beck, T., Billot, N., Bonfils, X., Brandeker, A., Broeg, C., Cabrera, J., Charnoz, S., Cameron, A. Collier, Van Damme, C. Corral, Csizmadia, Sz., Davies, M. B., Deleuil, M., Delrez, L., Demory, B. -O., Erikson, A., Farinato, J., Fortier, A., Fossati, L., Fridlund, M., Gandolfi, D., Gillon, M., Güdel, M., Hoyer, S., Isaak, K. G., Kiss, L. L., Kopp, E., Laskar, J., Etangs, A. Lecavelier des, Lovis, C., Magrin, D., Maxted, P. F. L., Mecina, M., Nascimbeni, V., Olofsson, G., Ottensamer, R., Pagano, I., Peter, G., Piazza, D., Piotto, G., Pollacco, D., Queloz, D., Ragazzoi, R., Rando, N., Rauer, H., Ribas, I., Scandariato, G., Ségransan, D., Simon, A. E., Smith, A. M. S., Steller, M., Szabó, Gy. M., Thomas, N., Udry, S., VanGrootel, V., and Walton, N. A.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Recent TESS-based studies have suggested that the dayside of KELT-1b, a strongly-irradiated brown dwarf, is significantly brighter in visible light than what would be expected based on Spitzer observations in infrared. We observe eight eclipses of KELT-1b with CHEOPS (CHaracterising ExOPlanet Satellite) to measure its dayside brightness temperature in the bluest passband observed so far, and model the CHEOPS photometry jointly with the existing optical and NIR photometry from TESS, LBT, CFHT, and Spitzer. Our modelling leads to a self-consistent dayside spectrum for KELT-1b covering the CHEOPS, TESS, H , Ks, and Spitzer IRAC 3.6 and 4.5 ${\mu}$m bands, where our TESS, H , Ks, and Spitzer band estimates largely agree with the previous studies, but we discover a strong discrepancy between the CHEOPS and TESS bands. The CHEOPS observations yield a higher photometric precision than the TESS observations, but do not show a significant eclipse signal, while a deep eclipse is detected in the TESS band. The derived TESS geometric albedo of $0.36^{+0.12}_{-0.13}$ is difficult to reconcile with a CHEOPS geometric albedo that is consistent with zero because the two passbands have considerable overlap. Variability in cloud cover caused by the transport of transient nightside clouds to the dayside could provide an explanation for reconciling the TESS and CHEOPS geometric albedos, but this hypothesis needs to be tested by future observations., Comment: Accepted to A&A
Published: 2022
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