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The effect of levodopa on muscle activity patterns in Parkinson’s disease (PD) patients is currently unclear. The aim of the present study was to compare the spatial distribution pattern of electromyographic activity during sustained isometric contraction in PD patients during on- and off-medication periods using multi-channel surface electromyography (SEMG). Ten female PD patients were recruited for the present study. All patients performed a sustained isometric knee extension at 10% maximum voluntary contraction task for 60 s. To evaluate alterations in the spatial SEMG potential distribution, the coefficient of variation (CV) of force, normalized root mean square (RMS), modified entropy, CV of the RMS, and correlation coefficients were calculated at during contraction task. The off-medication period exhibited more fluctuation during the contraction task than those in the on-medication period. The off-medication period exhibited less change in modified entropy, the CV of RMS, the correlation coefficient and patterns of spatial SEMG distribution. These data demonstrated that the heterogeneity and changes in the activation pattern are smaller in the off-medication period than in those in the on-medication period. These findings might indicate that levodopa enhanced the activation of muscle action potentials during force production.

We previously developed a novel technique to record surface electromyography (EMG) of the vastus intermedius (VI) in men. The purpose of the present study was to assess whether this technique can be applied to women in the same way. We measured the subcutaneous fat thickness at the site of electrode placement on VI using ultrasonography. Nine men and ten women performed isometric knee extensions at 25%, 50%, 75%, and 100% of the maximal voluntary contraction. During the tasks, surface EMG signals were recorded from the superficial region of VI with interelectrode distances (IEDs) of 10 mm (IED-10) and 20 mm (IED-20). The subcutaneous fat thickness in women was significantly greater than in men (women: 8.7 ± 2.1 mm; men: 5.6 ± 1.6 mm, p < 0.01). However, the amplitude and frequency of the EMG signal of VI at the different force levels were not affected by IEDs in either sex. These results suggest that surface EMG recording of VI with both IED-10 and IED-20 would be applicable to relatively lean women with a similar sensitivity to that in men.

Rhodium(I)-catalyzed asymmetric 1,4-addition of arylboronic acids 2 to coumarins 1 using ( S )-BICMAP as a chiral ligand gave the desired 4-arylchroman-2-one derivatives 2 in good yields and with high enantioselectivities (up to 99% ee).

To establish the per capita household waste arisings, door-to-door measurement of discharged waste was carried out. Survey was done in four 2-week phases over a period of 13 months. A questionnaire survey was also carried out to obtain data on household size and other household characteristics as well as the extent of reduce and recycle activities. The results showed that there is a big variance among households on waste arisings, and that household size is an important socio-economic factor in determining per capita waste generation.

Biomechanical and neurophysiological mechanisms of age-related gait dysfunction have not been fully understood. We aimed to investigate the relationship between region-specific electromyography (EMG) response of the rectus femoris (RF) muscle and lower extremity kinematics during swing phase of gait for the elderly. For thirteen elderly men (age: mean 71.3 years, standard deviation 5.7 years), multi-channel surface EMG from the proximal to distal regions of the RF muscle and lower extremity kinematics were measured during normal gait on a treadmill. At minimum foot clearance during swing phase, relationship between central locus activation (CLA), which is indicator of spatial distribution of surface EMG along the RF muscle and lower joint kinematics were calculated. No significant correlations were found between CLA and any joint angle (p > 0.05). The results of our study suggested that regional neuromuscular activation of the RF muscle is not associated to lower extremity joint movements and toe clearance strategy during gait in the elderly.

We found that the hydrazone–Pd-catalyzed direct intermolecular reaction of o-alkynylphenols with allylic acetates afforded the corresponding 2-substituted-3-allylbenzofuran derivatives. This reaction proceeded smoothly at room temperature using a hydrazone–Pd catalyst system.

INTRODUCTION We investigated the effect of workload and the use of pedal straps on the spatial distribution of neuromuscular activation within the rectus femoris (RF) muscle during pedaling movements. METHODS Eleven healthy men performed submaximal pedaling exercises on an electrically braked ergometer at different workloads and with or without pedal straps. During these tasks, surface electromyograms (SEMGs) were recorded from the RF using 36 electrode pairs, and central locus activation (CLA) was calculated along the longitudinal line of the muscle. RESULTS CLA moved markedly, indicating changes in spatial distribution of SEMG within the muscle, during a crank cycle under all conditions (P

This work addresses the semantic segmentation of images of street scenes for autonomous vehicles based on a new RGB-Thermal dataset, which is also introduced in this paper. An increasing interest in self-driving vehicles has brought the adaptation of semantic segmentation to self-driving systems. However, recent research relating to semantic segmentation is mainly based on RGB images acquired during times of poor visibility at night and under adverse weather conditions. Furthermore, most of these methods only focused on improving performance while ignoring time consumption. The aforementioned problems prompted us to propose a new convolutional neural network architecture for multi-spectral image segmentation that enables the segmentation accuracy to be retained during real-time operation. We benchmarked our method by creating an RGB-Thermal dataset in which thermal and RGB images are combined. We showed that the segmentation accuracy was significantly increased by adding thermal infrared information.

Objective The present study aimed to test the effect of the electrode position and inter-electrode distance on the evoked force by neuromuscular electrical stimulation (NMES) with a low current intensity and a single pair of electrodes. Knee extensor forces during NMES to quadriceps femoris muscles were compared among four different electrode configurations in seven healthy men. Electrodes were located at 10 cm proximal and 15 cm distal (P10-D15), 10 cm proximal and 10 cm distal (P10-D10), 5 cm proximal and 15 cm distal, and 5 cm proximal and 10 cm distal (P5-D10) to the center of the longitudinal axis of the quadriceps femoris muscles. Results The evoked force–time area for P5-D10 was significantly higher than those for P10-D15 and P10-D10 (p

This study aimed to examine muscle synergies involving the deeper muscles of the lower limb during level and uphill treadmill walking. Seven men and five women walked on a treadmill at three speeds (60, 80, and 100m/min) and two grades (level and 10% grade). Surface electromyographic (EMG) signals were recorded from 10 muscles of the lower limb, including vastus intermedius, adductor magnus, and adductor longus. Muscle synergies were extracted applying non-negative matrix factorization, and the relative co-activation across muscles and the temporal information of synergy recruitment were identified by the muscle synergy vector and synergy activation coefficient, respectively. Correlation coefficients between a pair of synergy vectors during level and uphill walking were analyzed as a similarity index, with the similarity criterion at r=0.76. Changes in synergy activation coefficients between the walking conditions were evaluated by cross-correlation analysis. The mean number of synergies ranged from 3.8 to 4.0 across all conditions, and they were not significantly different between level and uphill walking conditions. Similarity between walking conditions was high (r>0.76) for three muscle synergies, but not for one synergy that mainly consisted of the quadriceps femoris. The inter-condition similarity of the synergy activation coefficients was high for the four synergies, and a significant lag time for synergy 2, which consisted mainly of the activity of medial gastrocnemius, was found at 60 and 80m/min. The muscle synergies extracted from the lower limb involving the deeper muscles appear to be consistent during level and uphill treadmill walking.

This paper presents the results of an evaluation of three different types to geographical news classification methods: (1) simple keyword matching, a popular method in media and communications research; (2) geographical information extraction systems equipped with named-entity recognition and place name disambiguation mechanisms (Open Calais and Geoparser.io); (3) semi-supervised machine learning classifier developed by the author (Newsmap). Newsmap substitutes manual coding of news stories with dictionarybased labelling in creation of large training sets to extracts large number of geographical words without human involvement, and it also identifies multi-word names to reduce the ambiguity of the geographical traits fully automatically. The evaluation of classification accuracy of the three types of methods against 5,000 human-coded news summaries reveals that Newsmap outperforms the geographical information extraction systems in overall accuracy, while the simple keyword matching suffers from ambiguity of place names in countries with ambiguous place names.

Introduction: Our recent studies have demonstrated region-specific neural activation within the rectus femoris (RF) muscle. However, these studies involved a fixed joint angle or posture. In this study we investigated the effect of hip and knee joint angles on neural activation within RF using multichannel surface electromyography (SEMG). Methods: Eleven healthy men performed isometric maximal voluntary contraction (MVC) during knee extension and hip flexion at different hip or joint angles. During the contractions, SEMG of the RF was recorded using 46 electrode pairs covering most of the superficial area of the muscle. Results: During knee extension MVC, an increase in the hip joint angle was associated with a significant increase in SEMG amplitude in the proximal region and a decrease in the distal region (P

We report a new catalyst system, morpholine–NiCl2, for the Suzuki–Miyaura coupling of aryl chlorides with aryl- or alkenylboronic acids to give biaryl compounds. This catalyst system is easy to apply on a large scale because of its easy preparation and the use of inexpensive reagents. In addition, analysis of the residual nickel shows only 9.7 ppm remaining after normal work-up. This catalyst system has been applied to 26 compounds to give a variety of biaryl products, including hetero-biaryl compounds.

The surface interactions between xanthene (XN) dyes, including rhodamine B, rhodamine 3B, rhodamine 19, rhodamine 6G, rhodamine 110, and rhodamine 123, and tungsten(VI) oxide (WO3) colloid particles were investigated. These XN dyes were strongly adsorbed as a monolayer onto the WO3 surface via the electrostatic interaction between their peripheral cationic amino substituents and negatively surface-charged WO3 colloid particles, and most of the ones adsorbed eventually formed stable π-stacked dimers. The geometry of dimers formed on the WO3 colloid surface is discussed on the basis of the molecular exciton theory framework. Cationic XN dyes formed the approximately ideal face-to-face H-dimers on the WO3 colloid surface, whereas zwitterionic ones had a higher tendency to form the oblique J-dimers. Additionally, we have experimentally demonstrated the possibility of pH-induced switching between H- and J-aggregation modes of the XN dye’s dimers formed on the WO3 colloid surface. The findings lead to a better ...

A sustainable municipal waste recycling program is important to successfully increase the recycling rate in Malaysia. This paper evaluates and assesses the sustainability level of the recycling activities by Surau Al-Husna in Shah Alam, Malaysia. Five criteria were selected in the evaluation process. These criteria were divided into the continuous publicity of recycling programs, operation cost, participation rate/recyclables collection rate, dissemination of information regarding recycling and the enthusiasm level regarding environmental concerns. The results showed that Surau had a proper management system. However, several suggestions and recommendations were provided to improve the current recycling program. In conclusion, the Surau Al-Husna maintains sustainable recycling practices and is a good role model for sustainable recycling programs at the nationwide scale in Malaysia.

We aimed to test the effect of additional electrical muscle stimulation (EMS) during moderate-intensity voluntary pedaling exercise on metabolic and cardiovascular responses. Eleven healthy male subjects performed moderate-intensity pedaling exercise at a constant workload (80 % of ventilatory threshold) for 20 min while EMS was applied to thigh muscles from 5 to 10 min and from 15 to 20 min during the exercise. A significantly higher oxygen uptake (VO2), heart rate, and respiratory gas exchange ratio were observed during the exercise periods with EMS despite the constant workload. These changes were accompanied by an elevated blood lactate concentration, suggesting the existence of additional fast-twitch motor unit (MU) recruitment during the exercise with EMS. Our data suggest that the use of intermittent EMS during a constant load exercise mimics the high-intensity interval training, possibly due to additional fast-twitch MU recruitment and co-contractions of the quadriceps and hamstrings muscles, leading to higher anaerobic metabolism and a lower mechanical efficiency.

We report a new catalyst system, a morpholine–Pd(OAc)2 complex, for Suzuki–Miyaura coupling of aryl tosylates or mesylates with arylboronic acids to give biaryl compounds. The morpholine–Pd(OAc)2 catalyst system is proposed to be a precursor of the catalytically active species in the coupling reaction. Aryl chlorides and aryl triflates can also be used in this coupling reaction. Altogether, 22 biaryl compounds were obtained using this catalyst system.

Palladium-catalyzed decarboxylative coupling of benzoic acid derivatives with arylboroxins gave biaryls using a catalytic amount of Pd(TFA) 2 –hydrazone 1d system with Ag 2 CO 3 at 80 °C in good yields. We also found that decarboxylative coupling with aryl(trialkoxy)silanes gave biaryls using a Pd(TFA) 2 –hydrazone 1g system with AgF in good yields.

Prior research in patients has shown a positive correlation between morphological features associated with high-risk plaques and regions of high near-infrared autofluorescence (NIRAF) acquired via catheter-based multimodality optical coherence tomography (OCT)-NIRAF imaging. Subsequent ex vivo

Recent introduction of modern drainage systems has produced intensely dry conditions in rice farmlands and has degraded habitats for aquatic animals. In this study, we compared water beetle (Coleoptera) and water bug (Heteroptera) communities within rice fields cultivated under different management regimes: V-furrow no-till direct-seeding (DS) and conventional regimes. In DS fields, rice is sown in well-drained fields, and flooding is performed a month later than in conventional rice fields. DS fields are then continuously flooded until harvesting; unlike in conventional fields, where midseason drainage is performed in summer. We observed that DS fields supported higher densities of water beetles and water bugs than conventional fields, probably because of the high compatibility between the flooding period and the reproductive season of the insects. The species richness of water beetles was higher in DS fields than in conventional fields. Overall, DS fields showed higher water beetle and water bug abundance, but the effect was variable for individual species: seven species were more abundant in DS than in conventional fields, whereas two species showed opposite tendencies. Considering the differential responses among species to the management regimes, a mosaic of DS and conventional fields is preferable to either field alone for the conservation of aquatic insects in rice agroecosystems.

Shortly after the March 11th earthquake and tsunami in eastern Japan, a Task Team for Disaster Waste Management and Reconstruction was established within the Japan Society of Material Cycles and Waste Management (JSMCWM). One of the major tasks undertaken by the team was to create a manual entitled, Strategies for Separation and Treatment of Disaster Waste. In this paper, this JSMCWM manual is introduced, followed by a review of existing guidelines for disaster waste management in various countries. We identify useful guidelines created by international agencies, national and local governments. The JSMCWM manual adds our new experiences, especially characterized by a huge scale of disaster and tsunami information, to the existing knowledge with an emphasis on separation and subsequent treatment options. It should be desirable to share our knowledge and experiences, not only domestically but also with other countries in the world, especially regions that could be affected by large earthquake and tsunami events.

Introduction: We investigated the motor unit (MU) firing pattern in type 2 diabetes mellitus (T2DM) patients by means of multichannel surface electromyography (SEMG). Methods: Eight T2DM patients and 8 age-matched, healthy men performed a ramp-up contraction to 20% of maximal voluntary contraction (MVC). They also performed a sustained contraction at 10% of MVC during isometric knee extension. Multichannel SEMG signals recorded from the vastus lateralis muscle were decomposed with the convolution kernel compensation technique to extract individual MU firing patterns. Results: During the ramp contraction, the extent of MU firing modulation was significantly attenuated in T2DM. Variability of MU firing rate was significantly higher in T2DM at later periods during the sustained contraction. Conclusions: Our findings suggest that T2DM patients manifest characteristic MU activity patterns due possibly to some degree of neuromuscular impairment affecting the integrity of MU firing modulation. Muscle Nerve 48:806–813, 2013

Although the possibility that the vastus intermedius (VI) muscle contributes to flexion of the knee joint has been suggested previously, the detail of its functional role in knee flexion is not well understood. The purpose of this study was to examine the antagonist coactivation of VI during isometric knee flexion. Thirteen men performed 25-100% of maximal voluntary contraction (MVC) at 90°, 120°, and 150° knee joint angles. Surface electromyography (EMG) of the four individual muscles in the quadriceps femoris (QF) was recorded and normalized by the EMG signals during isometric knee extension at MVC. Cross-talk on VI EMG signal was assessed based on the median frequency response to selective cooling of hamstring muscles. Normalized EMG of the VI was significantly higher than that of the other synergistic QF muscles at each knee joint angle (all P0.05) with minimum cross-talk from the hamstrings to VI. There were significant correlations between the EMG signal of the hamstrings and VI (r=0.55-0.85, P0.001). These results suggest that VI acts as a primary antagonistic muscle of QF during knee flexion, and that VI is presumably a main contributor to knee joint stabilization.

Introduction Anatomical properties between proximal and other regions within the human rectus femoris (RF) muscle are nonuniform. We aimed to clarify the possible region-specific myoelectric manifestations of fatigue within the RF muscle by using an advanced surface electromyography (SEMG) technique. Methods Nine healthy men performed sustained contractions at 50% of maximal voluntary contraction until exhaustion during isometric knee extension and hip flexion. During these contractions, multi-channel SEMG was recorded from the RF by using 46 electrode pairs which cover most of the superficial area of the muscle. Results Fatigue-induced SEMG, i.e., an increase in root mean square and a decrease in median frequency, was not uniform within the muscle during both tasks and was greater in proximal regions. Conclusions Our findings suggest that myoelectric manifestations of fatigue within the human RF muscle are localized, and proximal regions are more fatigable than other regions within this muscle. Muscle Nerve, 48: 226–234, 2013

Disruption of the blood-brain barrier (BBB) can occur in various pathophysiological conditions. Administration of extraneous tracers that can pass the disrupted, but not the intact, BBB and detection of the extravasation have been widely used to assess BBB disruption in animal models. Although several fluorescent tracers have been successfully used, the administration of these tracers basically requires intravascular injection, which can be laborious when using small animals such as zebrafish. To identify fluorescent tracers that could be easily administered into various animal models and visualize the BBB disruption in vivo, we prepared nine structurally related indoline derivatives (IDs) as a minimum set of diverse fluorescent compounds. We found that one ID, ZMB741, had the highest affinity for serum albumin and emitted the strongest fluorescence in the presence of serum albumin of the nine IDs tested. The affinity to serum albumin and the fluorescence intensity was superior to those of Evans blue and indocyanine green that have been conventionally used to assess the BBB disruption. We showed that ZMB741 could be administered into zebrafish by static immersion or mice by intraperitoneal injection and visualizes the active disruption of their BBB. These results suggest that ZMB741 can be a convenient and versatile tool for in vivo fluorescent imaging of BBB disruption in various animal models. The strategy used in this study can also be applied to diversity-oriented libraries to identify novel fluorescent tracers that may be superior to ZMB741.

A survey to find out the level of recycling awareness of 400 students at Universiti Kebangsaan Malaysia (UKM), Bangi was conducted. The written questionnaires were focused on evaluation of waste management in UKM, recycling awareness and effective recycling bins design in UKM. The recycling facility was generally well supported, with predominantly positive recycling attitudes and self-reported recycling behaviour indicated for students. As conclusion, the survey conducted shows that the students are ready for recycling activities if the recycling facilities are provided and accessible to them.

In order to improve the performance of molten carbonates fuel cells, we have investigated the catalytic activity of LaNiO3 and NiO for the oxygen reduction reaction (ORR) on a meniscus electrode in Li/Na eutectic carbonates with La oxide. The apparent current density (i0) of LaNiO3 was slightly smaller than that of NiO. The partial pressure of CO2 (pCO2) and O2 (pO2) dependences of ORR were obtained on LaNiO3 and NiO, and the reaction mechanism of ORR on LaNiO3 was almost same to that on NiO at 923 K.

Despite recent advances in the synthesis of increasingly complex topologies at the molecular level, nano- and microscopic weaves have remained difficult to achieve. Only a few diaxial molecular weaves exist-these were achieved by templation with metals. Here, we present an extended triaxial supramolecular weave that consists of self-assembled organic threads. Each thread is formed by the self-assembly of a building block comprising a rigid oligoproline segment with two perylene-monoimide chromophores spaced at 18 Å. Upon π stacking of the chromophores, threads form that feature alternating up- and down-facing voids at regular distances. These voids accommodate incoming building blocks and establish crossing points through CH-π interactions on further assembly of the threads into a triaxial woven superstructure. The resulting micrometre-scale supramolecular weave proved to be more robust than non-woven self-assemblies of the same building block. The uniform hexagonal pores of the interwoven network were able to host iridium nanoparticles, which may be of interest for practical applications.

A large-scale quantitative analysis of geographic news coverage of Yahoo! News and Google News was conducted in the US and India using a content-analysis program to examine overrepresentation of developed countries in the US-based news portal sites. The results of the analysis show an absence of difference in the news coverage patterns of Yahoo! News and Google News between the US and India, which was predicted by the cultural imperialism thesis. However, it was found that Yahoo! News relies on western news agencies for news feeds, so it represents more developed countries; Google News has hundreds of news sources across the world, but its news coverage is highly concentrated and volatile. These findings can be explained by two ways by which western news agencies exercise their global influence on online news: news provision and agenda-setting.

Dye efflux assay evaluated by flow cytometry is useful for stem cell studies. The side population (SP) cells, characterized by the capacity to efflux Hoechst 33342 dye, have been shown to be enriched for hematopoietic stem cells (HSCs) in bone marrow. In addition, SP cells are isolated from various tissues and cell lines, and are also potential candidates for cancer stem cells. However, ultra violet (UV) light, which is not common for every flow cytometer, is required to excite Hoechst 33342. Here we showed that a fluorescent indoline dye ZMB793 can be excited by 488-nm laser, equipped in almost all the modern flow cytometers, and ZMB793-excluding cells showed SP phenotype. HSCs were exclusively enriched in the ZMB793-excluding cells, while ZMB793 was localized in cytosol of bone marrow lineage cells. The efflux of ZMB793 dye was mediated by ATP binding cassette (ABC) transporter Abcg2. Moreover, staining properties were affected by the side-chain structure of the dyes. These data indicate that the fluorescent dye ZMB793 could be used for the SP cell analysis.

Rice produces low-molecular-weight antimicrobial compounds known as phytoalexins, in response to not only pathogen attack but also abiotic stresses including ultraviolet (UV) irradiation. Rice phytoalexins are composed of diterpenoids and a flavonoid. Recent studies have indicated that endogenous jasmonyl-l-isoleucine (JA-Ile) is not necessarily required for the production of diterpenoid phytoalexins in blast-infected or CuCl2-treated rice leaves. However, JA-Ile is required for the accumulation of the flavonoid phytoalexin, sakuranetin. Here, we investigated the roles of JA-Ile in UV-induced phytoalexin production. We showed that UV-irradiation induces the biosynthesis of JA-Ile and its precursor jasmonic acid. We also showed that rice jasmonate biosynthesis mutants produced diterpenoid phytoalexins but not sakuranetin in response to UV, indicating that JA-Ile is required for the production of sakuranetin but not diterpenoid phytoalexins in UV-irradiated rice leaves.

Age-related changes in motor unit activation properties remain unclear for locomotor muscles such as quadriceps muscles, although these muscles are preferentially atrophied with aging and play important roles in daily living movements. The present study investigated and compared detailed motor unit firing characteristics for the vastus lateralis muscle during isometric contraction at low to moderate force levels in the elderly and young. Fourteen healthy elderly men and 15 healthy young men performed isometric ramp-up contraction to 70 % of the maximal voluntary contractions (MVC) during knee extension. Multichannel surface electromyograms were recorded from the vastus lateralis muscle using a two-dimensional grid of 64 electrodes and decomposed with the convolution kernel compensation technique to extract individual motor units. Motor unit firing rates in the young were significantly higher (~+29.7 %) than in the elderly (p 0.05). Firing rates at 60 % of the MVC force level for the motor units recruited at 0.05). These results suggest that the motor unit firing rate in the vastus lateralis muscle is affected by aging and muscle strength in the elderly and/or age-related strength loss is related to motor unit firing/recruitment properties.

Introduction: We quantified the alternate muscle activity among four synergists of the quadriceps femoris (QF), including the vastus intermedius (VI), during low-level sustained contraction. Methods: Surface electromyograms (EMGs) were recorded from the VI, vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) in 11 healthy men during isometric knee extension at 2.5% maximum voluntary contraction for 60 min to determine alternate muscle activity among the four synergists of the QF. Results: Alternate activity was primarily found between the RF and VI, VL, or VM, and rarely found among the vasti muscles. Multiple muscle comparison revealed the duration of alternate activity in the RF/VI+VL+VM combination remained high throughout the experiment, although the frequency of that combination did not. Conclusions: These results suggested that there is a fixed muscle combination, i.e., RF and the 3 vasti muscles, to perform low-intensity sustained contraction in the human QF. Muscle Nerve 46: 86–95, 2012

The purpose of this study was to compare the relationship between surface electromyography (EMG) and knee joint angle of the vastus intermedius muscle (VI) with the synergistic muscles in the quadriceps femoris (QF) muscle group. Fourteen healthy men performed maximal voluntary contractions during isometric knee extension at four knee joint angles from 90°, 115°, 140°, and 165° (180° being full extension). During the contractions, surface EMG was recorded at four muscle components of the QF muscle group: the VI, vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF) muscles. The root mean square of the surface EMG at each knee joint angle was calculated and normalized by that at a knee joint angle of 90° for individual muscles. The normalized RMS of the VI muscle was significantly lower than those of the VL and RF muscles at the knee joint angles of 115° and 165° and those of the VL, VM, and RF muscles at the knee joint angle of 140° (P

This is a study on the 2- bins recycling system at Universiti Kebangsaan Malaysia (UKM) year 2010 to reduce waste disposal at landfills. Fifty sets of 2-bins recycling system were allocated in the Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia (UKM). The number of recyclable items found in the recycling and mixed waste bins served as dependent measurements. Results indicated that the recycling containers successfully recovered recyclable items by 49.5%, but still a high proportion of recyclable items thrown into the mixed waste container which is 50.5% which indicates wrong bins usage. Awareness programs are required to increase rate of participation among students.

It is reported that the rate of locomotor muscle fatigue development during intermittent isometric exercise in hypoxia is accelerated compared with normoxia. In contrast, when sustained isometric contractions are used, some studies do not show any effect of hypoxia on fatigue development. Increased intramuscular pressure during sustained isometric exercise causes substantial and sustained ischemia, even in normoxia. Therefore, we hypothesized that the difference in muscle deoxygenation between normoxia and hypoxia would be small during sustained exercise compared with intermittent exercise and that this may contribute to the inconsistent findings.Subjects performed sustained and intermittent isometric, unilateral, and submaximal knee-extension exercises (60% maximal voluntary contraction to exhaustion) while breathing normoxic (inspired O2 fraction = 0.21) or hypoxic gas mixtures (inspired O2 fraction = 0.10-0.12). Muscle oxygenation (deoxyhemoglobin/myoglobin and tissue oxygenation index) using near-infrared spectroscopy and surface EMG were measured from the left vastus lateralis.During intermittent isometric exercise in hypoxia, increases in deoxyhemoglobin/myoglobin and reductions of tissue oxygenation index were larger (P0.05) than those in normoxia. The rate of rise in integrated EMG during intermittent exercise was accelerated (P0.05) in hypoxia. In contrast, there were no significant differences in changes in near-infrared spectroscopy variables and integrated EMG during sustained isometric exercise between normoxia and hypoxia.These results suggest that muscle deoxygenation is exaggerated during intermittent isometric exercise in hypoxia compared with normoxia, whereas during sustained isometric exercise, the extent of muscle deoxygenation is the same between normoxia and hypoxia. The different extent of muscle deoxygenation during sustained and intermittent isometric exercise in normoxia and hypoxia could affect muscle fatigability, which results from the varied rate of accumulation of metabolites.

Flounder metamorphosis, marked by eye migration, lateralized pigmentation, and tissue differentiation in the stomach and skeletal muscle, is stimulated by thyroid hormone (TH). It is known that tri-iodothyronine (T3) produced by iodothyronine deiodinase type-1 (Dio1) from thyroxine (T4) enters the blood, whereas T3 produced by Dio2 penetrates into the nucleus of the Dio2-expressing cells, and then Dio3 inactivates both T4 and T3. To better understand the distinct functions of these three deiodinases in T3 regulation during flounder metamorphosis, we examined the tissue expression patterns of dio1, dio2, and dio3 in larvae of the Japanese flounder, Paralichthys olivaceus, by section in situ hybridization (SISH). We found that each deiodinase is expressed in a spatially and temporally specific pattern. dio1 is expressed in liver parenchymal cells from pro-metamorphosis to early climax, while dio2 is expressed in limited regions of the eyes, tectum, and skeletal muscles from pro-metamorphosis to post-climax. Considering these findings together with reports on other vertebrates, we predict that the liver cells expressing dio1 supply T3 to the blood, and that this systemic T3 synchronizes metamorphosis of differentiating tissues throughout the larval body, whereas the eyes, tectum, and skeletal muscles autonomously produce additional T3 for local tissue differentiation. Finally, dio3 expression is detected in skeletal muscle and gastric gland blastemas, which both undergo marked tissue differentiation at metamorphic climax. We hypothesize that dio3 expression protects these tissues from basal T3 levels early in metamorphosis, ensuring, together with the T3 surge from the liver, the synchronization of tissue differentiation at metamorphic climax.