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201. Congenital Malformations in Children With Cerebral Palsy: Is Prematurity Protective?

Author

Sévère, Marcel, primary, Ng, Pamela, additional, Messerlian, Carmen, additional, Andersen, John, additional, Buckley, David, additional, Fehlings, Darcy, additional, Kirton, Adam, additional, Koclas, Louise, additional, Pigeon, Nicole, additional, Van Rensburg, Esias, additional, Wood, Ellen, additional, Shevell, Michael, additional, and Oskoui, Maryam, additional

Published
2020
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202. Guidelines for TMS/tES clinical services and research through the COVID-19 pandemic

Author

Bikson, Marom, primary, Hanlon, Colleen A., additional, Woods, Adam J., additional, Gillick, Bernadette T., additional, Charvet, Leigh, additional, Lamm, Claus, additional, Madeo, Graziella, additional, Holczer, Adrienn, additional, Almeida, Jorge, additional, Antal, Andrea, additional, Ay, Mohammad Reza, additional, Baeken, Chris, additional, Blumberger, Daniel M., additional, Campanella, Salvatore, additional, Camprodon, Joan A., additional, Christiansen, Lasse, additional, Loo, Colleen, additional, Crinion, Jennifer T., additional, Fitzgerald, Paul, additional, Gallimberti, Luigi, additional, Ghobadi-Azbari, Peyman, additional, Ghodratitoostani, Iman, additional, Grabner, Roland H., additional, Hartwigsen, Gesa, additional, Hirata, Akimasa, additional, Kirton, Adam, additional, Knotkova, Helena, additional, Krupitsky, Evgeny, additional, Marangolo, Paola, additional, Nakamura-Palacios, Ester M., additional, Potok, Weronika, additional, Praharaj, Samir K., additional, Ruff, Christian C., additional, Schlaug, Gottfried, additional, Siebner, Hartwig R., additional, Stagg, Charlotte J., additional, Thielscher, Axel, additional, Wenderoth, Nicole, additional, Yuan, Ti-Fei, additional, Zhang, Xiaochu, additional, and Ekhtiari, Hamed, additional

Published
2020
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209. Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial

Author

Barlow, Karen M., primary, Brooks, Brian L., additional, Esser, Michael J., additional, Kirton, Adam, additional, Mikrogianakis, Angelo, additional, Zemek, Roger L., additional, MacMaster, Frank P., additional, Nettel-Aguirre, Alberto, additional, Yeates, Keith Owen, additional, Kirk, Valerie, additional, Hutchison, James S., additional, Crawford, Susan, additional, Turley, Brenda, additional, Cameron, Candice, additional, Hill, Michael D., additional, Samuel, Tina, additional, Buchhalter, Jeffrey, additional, Richer, Lawrence, additional, Platt, Robert, additional, Boyd, Roslyn, additional, and Dewey, Deborah, additional

Published
2020
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215. Current Referral Practices for Diagnosis and Intervention for Children with Cerebral Palsy: A National Environmental Scan

Author

Boychuck, Zachary, primary, Andersen, John, additional, Fehlings, Darcy, additional, Kirton, Adam, additional, Oskoui, Maryam, additional, Shevell, Michael, additional, Majnemer, Annette, additional, Bergman, Howard, additional, Burko, Benjamin, additional, Dagenais, Emmanuelle, additional, Dagenais, Lynn, additional, Darsaklis, Vasiliki Betty, additional, Leduc, Denis, additional, Li, Patricia, additional, Shiller, Mitchell, additional, Snider, Laurie, additional, Thibault, Julie, additional, Ahmed, Sara, additional, Bussières, André, additional, Rodriguez, Rosario, additional, and Shikako Thomas, Keiko, additional

Published
2020
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223. Fibromuscular dysplasia and its neurological manifestations: a review

Author

Touzé, Emmanuel, Southerland, Andrew, Boulanger, Marion, Labeyrie, Paul-Emile, Azizi, Michel, Bouatia-Naji, Nabila, Debette, Stéphanie, Gornik, Heather, Hussain, Shazam, Jeunemaitre, Xavier, Joux, Julien, Kirton, Adam, Le Hello, Claire, Majersik, Jennifer, Mocco, J., Persu, Alexandre, Sharma, Aditya, Worrall, Bradford, Olin, Jeffrey, Plouin, Pierre-François, Service de neurologie, Hôpital Sainte-Anne, Laboratoire d'Accueil et de Recherche avec les Ions Accélérés (LARIA), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC AP-HP (hegp Ex-Broussais)/inserm, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU de la Martinique [Fort de France], Département de Médécine Vasculaire [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), and Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

225. Fibromuscular dysplasia of cervical and intracranial arteries

Author

Touzé, Emmanuel, Southerland, Andrew M, Labeyrie, Paul-Emile, Azizi, Michel, Boulanger, Marion, Boutia-Naji, Nabila, Debette, Stéphanie, Gornik, Heather L, Hussain, Shazam M, Jeunemaître, Xavier, Joux, Julien, Kirton, Adam, Le Hello, Claire, Majersik, Jennifer J, Mocco, J, Persu, Alexandre, Sharma, Aditya, Worrall, Bradford B, Olin, Jeffrey W, Plouin, Pierre-François, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, and UCL - (SLuc) Service de pathologie cardiovasculaire

Published
2019

232. Role of maxi-K+ channels in endothelin-induced vasoconstriction of mesenteric and submucosal arterioles

Author

Hill, Ceredwyn E., Kirton, Adam, Wu, Douglas D., and Vanner, Stephen J.

Subjects
Vasoconstriction -- Research, Endothelin -- Physiological aspects, Intestine, Small -- Physiological aspects, Smooth muscle -- Physiological aspects, Potassium channels -- Physiological aspects, Guinea pigs -- Physiological aspects, Biological sciences
Abstract

The mechanisms of action of endothelin and the maxi-potassium+ (maxi-K+) channels in the vasoconstriction of mesenteric and submucosal arteriole smooth muscle cells of the small intestine were investigated. Male albino guinea pigs were used as experimental models to determine the function of endothelin in resistance arterioles by measuring vasomotor activity in the vessels and monitoring membrane electrical properties in acutely dissociated smooth muscle cells. Results showed that opening maxi-K+ channels attenuated the impact of contraction induced by endothelin-1.

Published
1997

236. Cerebral palsy in Canadian Indigenous children.

Author

Chen, Anjellica, Dyck Holzinger, Sasha, Oskoui, Maryam, Shevell, Michael, Andersen, John, Buckley, David, Fehlings, Darcy, Burkholder, Lee, Kirton, Adam, Koclas, Louise, Pigeon, Nicole, Van Rensburg, Esias, Sheriko, Jordan, and Wood, Ellen

Subjects
INDIGENOUS children, ABORIGINAL Canadians, CEREBRAL palsy, CHILDREN with cerebral palsy, INDIGENOUS peoples
Abstract

Aim: To determine whether inequities in health outcomes for Indigenous Canadians are also present in cerebral palsy (CP) by comparing CP profiles between Indigenous and non‐Indigenous children. Method: Using the Canadian Cerebral Palsy Registry, we conducted a cross‐sectional study. CP motor subtype, gross motor severity, comorbidities, perinatal adversity, preterm birth, and parental education were compared between 94 Indigenous (53 males, 41 females) and 1555 non‐Indigenous (891 males, 664 females) children (all >5y). Multivariate analysis was done to analyze adverse CP factors, defined as CP gross motor severity and comorbidities. CP etiologies, either prenatal/perinatal or postnatal, were also compared. Results: Indigenous children with CP have higher odds of having low parental education (odds ratio [OR] 6.15, 95% confidence interval [CI] 3.36–11.3) and comorbidities (OR 4.46, 95% CI 1.62–12.3), especially cognitive (OR 4.52, 95% CI 2.27–9.05), communication (OR 2.66, 95% CI 1.54–4.61), and feeding (OR 2.25, 95% CI 1.33–3.83) impairment. Indigenous children also have higher CP gross motor severity (p=0.03). Indigenous children are also more likely to have non‐accidental head injury (n=4; OR 8.18, 95% CI 1.86–36.0) as the cause of their postnatal CP. Interpretation: Indigenous populations have worse health outcomes as a result of intergenerational impacts of colonization. Our study shows that Indigenous children with CP have increased comorbidities and higher CP gross motor severity, reinforcing the need for a multidisciplinary approach to management. Furthermore, targeted prevention programs against preventable causes of CP, such as non‐accidental head injury, may be beneficial. What this paper adds: Indigenous children with cerebral palsy (CP) have more severe motor impairment and more comorbidities.Non‐accidental head injury is a significant cause of postnatal CP. What this paper adds: Indigenous children with cerebral palsy (CP) have more severe motor impairment and more comorbidities.Non‐accidental head injury is a significant cause of postnatal CP. This article is commented on by King on page 500 of this issue. [ABSTRACT FROM AUTHOR]

Published
2021
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237. Goals of children with unilateral cerebral palsy in a brain stimulation arm rehabilitation trial.

Author

Metzler, Megan J, Haspels, Eva, Brunton, Laura, Andersen, John, Pritchard, Lesley, Herrero, Mia, Hodge, Jacquie, and Kirton, Adam

Subjects
BRAIN stimulation, CHILDREN with cerebral palsy, TRANSCRANIAL magnetic stimulation, GOAL (Psychology), REHABILITATION, FORELIMB
Abstract

Aim: To explore relationships between category classifications for children's rehabilitation goals, outcomes, and participant characteristics. Method: Children with hemiparetic cerebral palsy due to perinatal stroke rated self‐selected goals with the Canadian Occupational Performance Measure (COPM) and completed the Assisting Hand Assessment (AHA) and Box and Block Test (BBT), at baseline and 6 months, in a randomized, controlled 10‐day neuromodulation rehabilitation trial using repetitive transcranial magnetic stimulation. Goals were classified with the Canadian Model of Occupational Performance and Engagement and the International Classification of Functioning, Disability and Health. Analysis included standard linear regression. Results: Data for 45 participants (mean age 11y 7mo, SD 3y 10mo, range 6–19y, 29 males, 16 females) on 186 goals were included. Self‐care goal percentage corresponded with baseline BBT by age (standardized ß=–0.561, p=0.004). Leisure goal percentage corresponded with baseline BBT (standardized ß=0.419, p=0.010). AHA change corresponded with productivity goals (standardized ß=0.327, p=0.029) and age (standardized ß=0.481, p=0.002). COPM change corresponded with baseline COPM and age by AHA change (p<0.05). Interpretation: Younger children with lower motor function were more likely to select self‐care goals while those with better function tended to select leisure goals. Functional improvement corresponded with older age and productivity goals. COPM change scores reflected functional improvement among older children. Children chose functionally and developmentally appropriate goals. Consequently, children should be free to set goals that matter to them. What this paper adds: Children in a brain stimulation trial chose divergent upper extremity functional goals.Younger children with lower ability chose more self‐care goals.Children with higher ability chose more leisure goals.Older children's goal ratings reflected objective functional motor gains.Children chose goals appropriate to their function and level of development. What this paper adds: Children in a brain stimulation trial chose divergent upper extremity functional goals.Younger children with lower ability chose more self‐care goals.Children with higher ability chose more leisure goals.Older children's goal ratings reflected objective functional motor gains.Children chose goals appropriate to their function and level of development. [ABSTRACT FROM AUTHOR]

Published
2021
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238. Mortality after pediatric arterial ischemic stroke

Author

Beslow, Lauren A., Dowling, Michael M., Hassanein, Sahar M.A., Lynch, John K., Zafeiriou, Dimitrios, Sun, Lisa R., Kopyta, Ilona, Titomanlio, Luigi, Kolk, Anneli, Chan, Anthony, Biller, Jose, Grabowski, Eric F., Abdalla, Abdalla A., Mackay, Mark T., DeVeber, Gabrielle, Ashwal, Steve, Ferriero, Donna, Fullerton, Heather, Ichord, Rebecca, Kirkham, Fenella, O'Callaghan, Finbar, Pavlakis, Steve, Sebire, Guillaume, Willan, Andrew, Kirton, Adam, Goldenberg, Neil, Saengpattrachai, Montri, Crosswell, Hal, Rivkin, Michael, Bjornson, Bruce, Tatishvili, Nana, Brankovic-Sreckovic, Vesna, Bernard, Timothy, Armstrong, Jennifer, Humphreys, Peter, Heyer, Geoffrey, Fryer, Robert, Yeh, Ann, Billinghurst, Lori, Khoury, Chaouki, Abraham, Lisa, Whelan, Harry, Nowak-Gottl, Ulrike, Wainwright, Mark, Condie, John, Carpenter, Jessica, Holzhauer, Susanne, Guang, Yang, Zou, Li Ping, Taylor, J. Michael, and Pediatrics

Subjects
Heart Defects, Congenital, Male, Pediatrics, medicine.medical_specialty, Multivariate analysis, Heart disease, Infarction, Disease, Brain Ischemia, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, 030225 pediatrics, medicine, Humans, Hospital Mortality, Registries, Child, Stroke, business.industry, Infant, Newborn, Infant, Odds ratio, Hispanic or Latino, medicine.disease, Confidence interval, United States, Hospitalization, Child, Preschool, Pediatrics, Perinatology and Child Health, Multivariate Analysis, Female, business, 030217 neurology & neurosurgery
Abstract

OBJECTIVES: Cerebrovascular disease is among the top 10 causes of death in US children, but risk factors for mortality are poorly understood. Within an international registry, we identify predictors of in-hospital mortality after pediatric arterial ischemic stroke (AIS). METHODS: Neonates (0–28 days) and children (29 days– RESULTS: Fourteen of 915 neonates (1.5%) and 70 of 2273 children (3.1%) died during hospitalization. Of 48 cases with reported causes of death, 31 (64.6%) were stroke-related, with remaining deaths attributed to medical disease. In multivariable analysis, congenital heart disease (odds ratio [OR]: 3.88; 95% confidence interval [CI]: 1.23–12.29; P = .021), posterior plus anterior circulation stroke (OR: 5.36; 95% CI: 1.70–16.85; P = .004), and stroke presentation without seizures (OR: 3.95; 95% CI: 1.26–12.37; P = .019) were associated with in-hospital mortality for neonates. Hispanic ethnicity (OR: 3.12; 95% CI: 1.56–6.24; P = .001), congenital heart disease (OR: 3.14; 95% CI: 1.75–5.61; P < .001), and posterior plus anterior circulation stroke (OR: 2.71; 95% CI: 1.40–5.25; P = .003) were associated with in-hospital mortality for children. CONCLUSIONS: In-hospital mortality occurred in 2.6% of pediatric AIS cases. Most deaths were attributable to stroke. Risk factors for in-hospital mortality included congenital heart disease and posterior plus anterior circulation stroke. Presentation without seizures and Hispanic ethnicity were also associated with mortality for neonates and children, respectively. Awareness and study of risk factors for mortality represent opportunities to increase survival.

Published
2018

239. Supplemental material for Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy

Author

Ladhani, Noor Niyar N, Swartz, Richard H, Foley, Norine, Nerenberg, Kara, Smith, Eric E, Gord Gubitz, Dowlatshahi, Dariush, Potts, Jayson, Ray, Joel G, Barrett, Jon, Bushnell, Cheryl, Simerpreet Bal, Wee-Shian Chan, Chari, Radha, Amrani, Meryem El, Shital Gandhi, Hill, Michael D, James, Andra, Jeerakathil, Thomas, Jin, Albert, Kirton, Adam, Lanthier, Sylvain, Lausman, Andrea, Leffert, Lisa Rae, Mandzia, Jennifer, Menon, Bijoy, Pikula, Aleksandra, Poppe, Alexandre, Saposnik, Gustavo, Sharma, Mukul, Sanjit Bhogal, Smitko, Elisabeth, and M Patrice Lindsay

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material for Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy by Noor Niyar N Ladhani, Richard H Swartz, Norine Foley, Kara Nerenberg, Eric E Smith, Gord Gubitz, Dariush Dowlatshahi, Jayson Potts, Joel G Ray, Jon Barrett, Cheryl Bushnell, Simerpreet Bal, Wee-Shian Chan, Radha Chari, Meryem El Amrani, Shital Gandhi, Michael D Hill, Andra James, Thomas Jeerakathil, Albert Jin, Adam Kirton, Sylvain Lanthier, Andrea Lausman, Lisa Rae Leffert, Jennifer Mandzia, Bijoy Menon, Aleksandra Pikula, Alexandre Poppe, Gustavo Saposnik, Mukul Sharma, Sanjit Bhogal, Elisabeth Smitko and M Patrice Lindsay; on behalf of the Heart and Stroke Foundation Canadian Stroke Best Practice and Quality Advisory Committees; in collaboration with the Canadian Stroke Consortium in International Journal of Stroke

Published
2018
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240. Supplementary_Figure – Supplemental material for Intervention-Induced Motor Cortex Plasticity in Hemiparetic Children With Perinatal Stroke

Author

Hsing-Ching Kuo, Zewdie, Ephrem, Ciechanski, Patrick, Damji, Omar, and Kirton, Adam

Subjects
FOS: Clinical medicine, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, Supplementary_Figure for Intervention-Induced Motor Cortex Plasticity in Hemiparetic Children With Perinatal Stroke by Hsing-Ching Kuo, Ephrem Zewdie, Patrick Ciechanski, Omar Damji and Adam Kirton in Neurorehabilitation and Neural Repair

Published
2018
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241. Position Statement:Emerging genetic therapies for rare disorders

Author

Samia, Pauline, primary, Kirton, Adam, additional, Dale, Russell, additional, Tenembaum, Silvia, additional, Triki, Chahnez Charfi, additional, Hegde, Anaita, additional, Idro, Richard, additional, Kija, Edward, additional, Wilmshurst, Jo M, additional, Tein, Ingrid, additional, and Topaloğlu, Haluk, additional

Published
2019
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246. Profile of children with cerebral palsy spectrum disorder and a normal MRI study

Author

Springer, Arielle, primary, Dyck Holzinger, Sasha, additional, Andersen, John, additional, Buckley, David, additional, Fehlings, Darcy, additional, Kirton, Adam, additional, Koclas, Louise, additional, Pigeon, Nicole, additional, Van Rensburg, Esias, additional, Wood, Ellen, additional, Oskoui, Maryam, additional, and Shevell, Michael, additional

Published
2019
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248. Cognitive outcomes of childhood primary CNS vasculitis.

Author

Deschamps, Kristen, primary, Yeates, Keith Owen, additional, Fay-McClymont, Taryn B., additional, Twilt, Marinka, additional, Westmacott, Robyn, additional, Dropol, Anastasia, additional, Brooks, Brian L., additional, Kirton, Adam, additional, Gowdie, Peter, additional, Sheikh, Shehla, additional, and Benseler, Susanne M., additional

Published
2019
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