1,111 results on '"Kayser, M."'
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202. Posttraumatisches Impingementsyndrom nach schultergelenknahen knöchernen Verletzungen
- Author
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Kayser, M., primary, Lies, A., additional, and Josten, Ch., additional
- Published
- 1988
- Full Text
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203. Kann die operative Therapie von Fersenbeinbrüchen Spätfolgen verhindern?
- Author
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Knopp, W., primary, Neumann, K., additional, Vogelheim, P., additional, and Kayser, M., additional
- Published
- 1988
- Full Text
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204. Precision electroweak measurements on the Z resonance
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Schael, S, Barate, R, Bruneliere, R, Buskulic, D, Bonis, De, Decamp, I, Ghez, D, Goy, P, Jezequel, C, Lees, S, Lucotte, Jp, Martin, A, Merle, F, Minard, E, Nief, Mn, Odier, Jy, Pietrzyk, P, Trocme, B, Bravo, B, Casado, S, Chmeissani, Mp, Comas, M, Crespo, P, Fernandez, Jm, E, Fernandez, Bosman, Garrido, M, Grauges, L, Juste, E, Martinez, A, Merino, M, Miquel, G, Mir, R, Orteu, Lm, Pacheco, S, Park, A, Perlas, Ic, Riu, J, Ruiz, I, Sanchez, H, Colaleo, F, Creanza, A, D, Filippis, De, N, Palma, De, Iaselli, M, Maggi, G, Nuzzo, M, Ranieri, S, Raso, A, Ruggieri, G, Selvaggi, F, Silvestris, G, Tempesta, L, Tricomi, P, Zito, A, Huang, G, Lin, X, Ouyang, J, Wang, Q, Xie, T, Xu, Y, Xue, R, Zhang, S, Zhang, J, Zhao, L, Abbaneo, W, Bazarko, D, Becker, A, Boix, U, Bird, G, Blucher, F, Bonvicini, E, B, Bright, Thomas, Barklow, P, Buchmuller, T, Cattaneo, O, Cerutti, M, Ciulli, F, Clerbaux, V, Drevermann, B, Forty, H, Frank, Rw, Greening, M, Hagelberg, Tc, Halley, R, Gianotti, Aw, Girone, F, Hansen, M, Harvey, Jb, Jacobsen, J, Hutchcroft, R, Janot, De, Jost, R, Knobloch, B, Kado, J, Lehraus, M, Lazeyras, I, Maley, P, Mato, R, May, P, Moutussi, J, A, Pepe, Altarelli, Ranjard, M, Rolandi, F, Schlatter, L, Schmitt, D, Schneider, B, Tejessy, O, Teubert, W, Tomalin, F, Tournefier, Ir, Veenhof, E, Valassi, R, Wiedenmann, A, Wright, W, Ajaltouni, Ae, Badaud, Z, Chazelle, F, Deschamps, G, Dessagne, O, Falvard, S, Ferdi, A, Fayolle, C, Gay, D, Guicheney, P, Henrard, C, Jousset, P, Michel, J, Monteil, B, Montret, S, Pallin, Jc, Pascolo, D, Perret, Jm, Podlyski, P, Bertelsen, F, Fernley, H, Hansen, T, Hansen, Jd, Hansen, Jr, Kraan, Ph, Lindahl, Ac, Mollerud, A, Nilsson, R, Rensch, Bs, Waananen, B, Daskalakis, A, Kyriakis, G, Markou, A, Simopoulou, C, Siotis, E, Vayaki, I, Zachariadou, A, Blondel, K, Bonneaud, A, Brient, G, Machefert, Jc, Rouge, E, Rumpf, A, Swynghedauw, M, Tanaka, M, Verderi, R, Videau, M, Focardi, H, Parrini, E, Corden, G, Georgiopoulos, M, Antonelli, C, Antonelli, A, Bencivenni, M, Bologna, G, Bossi, G, Campana, F, Capon, P, Chiarella, G, Felici, V, Laurelli, G, Mannocchi, P, Murtas, G, Passalacqua, Gp, Picchi, L, Colrain, P, P, Ten, Have, Hughes, I, Kennedy, Is, Knowles, J, Lynch, Ig, Morton, Jg, Negus, Wt, Oshea, P., Raine, V, Reeves, C, Scarr, P, Smith, Jm, Thompson, K., Turnbull, As, Wasserbaech, Rm, Cavanaugh, S, Dhamotharan, R, Geweniger, S, Hanke, C, Hansper, P, Hepp, G, Kluge, V, Putzer, Ee, Sommer, A, Stenzel, J, Tittel, H, Werner, K, Wunsch, W, Beuselinck, M, Binnie, R, Cameron, Dm, Davies, W, Dornan, G, Goodsir, Pj, Marinelli, S, Martin, N, Nash, Eb, Nowell, J, Rutherford, J, Sedgbeer, Sa, Thompson, Jk, White, Jc, Williams, R, Ghete, Md, Girtler, Vm, Kneringer, P, Kuhn, E, Rudolph, D, G, Bouhova, Thacker, Bowdery, E, Buck, Ck, Clarke, Pg, Ellis, Dp, Finch, G, Foster, Aj, Hughes, F, Jones, G, Rwl, Keemer, Pearson, Nr, Robertson, Mr, Sloan, Na, Smizanska, T, Snow, M, Williams, Sw, van der Aa, Delaere, O, Leibenguth, C, Lemaitre, G, Bauerdick, V, Lat, Blumenschein, U, Van, Gemmeren, Giehl, P, Holldorfer, I, Jakobs, F, Kasemann, K, Kayser, M, Kleinknecht, F, Muller, K, Quast, As, Renk, G, Rohne, B, Sander, E, Schmeling, Hg, Wachsmuth, S, Wanke, H, Zeitnitz, R, Ziegler, C, Aubert, T, Benchouk, Jj, Bonissent, C, Carr, A, Coyle, J, Curtil, P, Ealet, C, Etienne, A, Fouchez, F, Motsch, D, Payre, F, Rousseau, P, Tilquin, D, Talby, A, Thulasides, M, Aleppo, M, Ragusa, M, Buscher, F, David, V, Dietl, A, Ganis, H, Huttmann, G, Lutjens, K, Mannert, G, Manner, C, Moser, W, Settles, Hg, Seywerd, R, Villegas, H, Wolf, M, Azzurri, G, Boucrot, P, Callot, J, Chen, O, Cordier, S, Davier, A, Duflot, M, Grivaz, L, Heusse, Jf, Jacholkowska, P, Diberder, Le, Lefrancois, F, Mutz, J, Schune, Am, Serin, Mh, Veillet, L, Videau, Jj, Zerwas, I, Bagliesi, D, Bettarini, G, Boccali, S, Bozzi, T, Calderini, C, Dellorso, G, Fantechi, R, Ferrante, R, Fidecaro, I, Foa, F, Giammanco, L, Giassi, A, Gregorio, A, Ligabue, A, Lusiani, F, Marrocchesi, PIER SIMONE, Messineo, Ps, Palla, A, Rizzo, F, Sanguinetti, G, Sciaba, G, Sguazzoni, A, Spagnolo, G, Steinberger, P, Tenchini, J, Venturi, R, Vannini, A, Verdini, C, Awunor, Pg, Blair, O, Cowan, Ga, Garcia, Bellido, Green, A, Medcalf, Mg, Misiejuk, T, Strong, A, Teixeira, Dias, Botterill, P, Clifft, Dr, Edgecock, Rw, Edwards, Tr, Haywood, M, Norton, Sj, Ward, Pr, Bloch, Devaux, Boumediene, B, Colas, D, Emery, P, Fabbro, S, Kozanecki, B, Lancon, W, Lemaire, E, Locci, Mc, Perez, E, Rander, P, Renardy, J, Roussarie, Jf, Schuller, A, Schwindling, Jp, Tuchming, J, Vallage, B, Black, B, Dann, Sn, Kim, Jh, Konstantinidis, Hy, Litke, N, Mcneil, Am, Taylor, Ma, Booth, G, Cartwright, Cn, Combley, S, Hodgson, F, Lehto, Pn, Thompson, M, Affholderbach, Lf, Barberio, K, Bohrer, E, Brandt, A, Burkhardt, S, Feigl, H, Grupen, E, Hess, C, Lutters, J, Meinhard, G, H, Minguet, Rodriguez, Mirabito, J, Neugebauer, L, Ngac, E, Prange, A, Rivera, G, Saraiva, F, Schafer, P, Sieler, U, Smolik, U, Stephan, L, Trier, F, Apollonio, H, Borean, M, Bosisio, C, L, Della, Marina, Giannini, R, Gobbo, G, Musolino, B, Pitis, G, He, L, Kim, H, Putz, H, Rothberg, J, Armstrong, J, Bellantoni, Sr, Berkelman, L, Cinabro, K, Conway, D, Cranmer, Js, Elmer, K, Feng, P, Ferguson, Z, Dps, Gao, Gonzalez, Y, Grahl, S, Harton, J, Hayes, Jl, Hu, Oj, Jin, H, Johnson, S, Kile, Rp, Mcnamara, J, Nielsen, Pa, Orejudos, J, Pan, W, Saadi, Y, Scott, Y, Sharma, Ij, Walsh, V, Walsh, Am, Wear, J, J, von Wimmersperg Toeller, Wu, Jh, Wu, J, Wu, Sl, Yamartino, X, Zobernig, Jm, Dissertori, G, Abdallah, G, Abreu, J, Adam, P, Adye, W, Adzic, T, Ajinenko, P, Albrecht, I, Alderweireld, T, Alekseev, T, Alemany, Fernandez, Allmendinger, R, Allport, T, Almehed, Pp, Amaldi, S, Amapane, U, Amato, N, Anashkin, S, Anassontzis, E, Andersson, Eg, Andreazza, P, Andringa, A, Anjos, S, Antilous, N, Apel, P, Arnoud, Wd, Ask, Y, Asman, S, Augustin, B, Augustinus, Je, Baillon, A, Ballestrero, P, Bambade, A, Barao, P, Barbiellini, F, Barbier, G, Bardin, R, Barker, D, Baroncelli, G, Battaglia, A, Baubillier, M, Becks, M, Begalli, Kh, Behrmann, M, Beilliere, A, Belokopytov, P, Belous, Y, K, Ben, Haim, Benekos, E, Benvenuti, N, Berat, A, Berggren, C, Berntzon, M, Bertini, L, Bertrand, D, Besancon, D, Besson, M, Bianchi, N, Bigi, F, Bilenky, M, Bizouard, Ms, Bloch, Ma, Blom, D, Bluj, M, Bonesini, M, Bonivento, M, Boonekamp, W, Booth, M, Psl, Borgland, Borisov, Aw, Bosio, G, Botner, C, Boudinov, O, Bouquet, E, Bourdarios, B, Bowcock, C, Tjv, Boyko, Bozovic, I, Bozzo, I, Bracko, M, Branchini, M, Brenke, P, Brenner, T, Brodet, R, Bruckman, E, Brunet, P, Bugge, Jm, Buran, L, Burgsmueller, T, Buschbeck, T, Buschmann, B, Cabrera, P, Caccia, S, Calvi, M, Rozas, M, Ajc, Camporesi, Canale, T, Canepa, V, Carena, M, Carroll, F, Caso, L, Gimenez, C, Mvc, Castro, Cattai, N, Cavallo, A, Cerruti, F, Chabaud, C, Chapkin, V, Charpentier, M, Chaussard, P, Checchia, L, Chelkov, P, Chen, Ga, Chierici, M, Chliapnikov, R, Chochula, R, Chorowicz, P, Chudoba, V, Chung, J, Cieslik, Su, Collins, K, Colomer, P, Contri, M, Cortina, R, Cosme, E, Cossuti, G, Costa, F, Cowell, Mj, Crawley, Jh, Crennell, Hb, Crepe, D, Crosetti, S, Cuevas, G, Czellar, J, Dhondt, S, Dalmagne, J, Dalmau, B, Damgaard, J, Davenport, G, M, Silva, Da, T, Deghorain, W, Della, Ricca, Delpierre, G, Demaria, P, Angelis, De, Boer, De, W, Brabandere, De, S, Clercq, De, C, Lotto, De, Maria, De, Min, De, Paula, De, Dijkstra, L, Ciaccio, Di, Diodato, Di, Simone, Di, Djannati, A, Dolbeau, A, Doroba, J, Dracos, K, Drees, M, Drees, J, Dris, Ka, Duperrin, M, Durand, A, Ehret, Jd, Eigen, R, Ekelof, G, Ekspong, T, Ellert, G, Elsing, M, Engel, M, Erzen, Jp, Santo, B, Mce, Falk, Fanourakis, E, Fassouliotis, G, Fayot, D, Feindt, J, Fenyuk, M, Fernandez, A, Ferrari, J, Ferrer, P, Ferrer, Ribas, Ferro, E, Fichet, F, Firestone, S, Fischer, A, Flagmeyer, Pa, Foeth, U, Fokitis, H, Fontanelli, E, Franek, F, Frodesen, B, Fruhwirth, Ag, R, Fulda, Quenzer, Fuster, F, Galloni, J, Gamba, A, Gamblin, D, Gandelman, S, Garcia, M, Garcia, C, Gaspar, J, Gaspar, C, Gasparini, M, Gavillet, U, Gazis, P, Gele, E, Gerber, D, Gerdyukov, Jp, Ghodbane, L, Gil, N, Glege, I, Gokieli, F, Golob, R, Gomez, Ceballos, Goncalves, G, Caballero, P, Gopal, Ig, Gorn, G, Gorski, L, Gouz, M, Gracco, Y, Graziani, V, Green, E, Grefrath, C, Grimm, A, Gris, Hj, Grosdidier, P, Grzelak, G, Gunther, K, Guy, M, Haag, J, Hahn, C, Hahn, F, Hallgren, S, Hamacher, A, Hamilton, K, Hansen, K, Harris, J, Haug, Fj, Hauler, S, Hedberg, F, Heising, V, Hennecke, S, Henriques, M, Hernandez, R, Herquet, Jj, Herr, P, Hessing, H, Heuser, Tl, Higon, Jm, Hoffman, E, Holmgren, J, Holt, So, Holthuizen, Pj, Hoorelbeke, D, Houlden, S, Hrubec, Ma, Huber, J, Huet, M, Hughes, K, Hultqvist, Gj, Jackson, K, Jacobsson, Jn, Jalocha, R, Janik, P, Jarlskog, R, Jarlskog, C, Jarry, G, Jean, Marie, Jeans, B, Johansson, D, Johansson, Ek, Jonsson, Pd, Joram, P, Juillot, C, Jungermann, P, Kapusta, L, Karafasoulis, F, Katsanevas, K, Katsoufis, S, Keranen, E, Kernel, R, Kersevan, G, Kerzel, Bp, Khomenko, U, Khovanski, Ba, Kiiskinen, Nn, King, A, Kinvig, Bt, Kjaer, A, Klapp, Nj, Klein, O, Kluit, H, Knoblauch, P, Kokkinias, D, Konopliannikov, P, Koratzinos, A, Kostioukhine, M, Kourkoumelis, V, Kouznetsov, C, Krammer, O, Kreuter, M, Kriznic, C, Krstic, E, Krumstein, J, Kubinec, Z, Kucewicz, P, Kucharczyk, W, Kurowska, M, Kurvinen, J, Lamsa, K, Lanceri, J, Lane, L, Langefeld, Dw, Lapin, P, Laugier, V, Lauhakangas, Jp, Leder, R, Ledroit, G, Lefebure, F, Leinonen, V, Leisos, L, Leitner, A, Lemonne, R, Lenzen, J, Lepeltier, G, Lesiak, V, Lethuillier, T, Libby, M, Liebig, J, Liko, W, Lipniacka, D, Lippi, A, Loerstad, I, Lokajicek, B, Loken, M, Lopes, Jg, Lopez, Jh, Lopez, Femandez, Loukas, R, Lutz, D, Lyons, P, Macnaughton, L, Mahon, J, Maio, Jr, Malek, A, Malmgren, A, Tgm, Maltezos, Malychev, S, Mandl, V, Marco, F, Marco, J, Marechal, R, Margoni, B, Marin, M, Mariotti, Jc, Markou, C, Martinez, Rivero, Martinez, Vidal, Garcia, F, Smi, Masik, Mastroyiannopoulos, J, Matorras, N, Matteuzzi, F, Matthiae, C, Mazik, G, Mazzucato, J, Mazzucato, F, Mccubbin, M, Mckay, M, Mcnulty, R, Meroni, R, Meyer, C, Miagkov, Wt, Migliore, A, Mitaroff, E, Mjoernmark, W, Moa, U, Moch, T, Moeller, M, Moenig, R, Monge, K, Montenegro, R, Moraes, J, Moreau, D, Moreno, X, Morettini, S, Morton, P, Mueller, G, Muenich, U, Mulders, K, Mulet, Marquis, Mundim, C, Muresan, L, Murray, R, Muryn, W, Myatt, B, Myklebust, G, Naraghi, T, Nassiakou, F, Navarria, M, Navas, F, Nawrocki, S, Negri, K, Neufeld, P, Neumann, N, Neumeister, W, Nicolaidou, N, Nielsen, R, Nieuwenhuizen, Bs, Niezurawski, M, Nikolaenko, P, Nikolenko, V, Nomokonov, M, Normand, V, Nygren, A, Oblakowska, Mucha, Obraztsov, A, Olshevski, V, Onofre, A, Orava, A, Orazi, R, Osterberg, G, Ouraou, K, Oyanguren, A, Paganini, A, Paganoni, P, Paiano, M, Pain, S, Paiva, R, Palacios, R, Palka, Jp, Papadopoulou, H, Papageorgiou, Td, Pape, K, Parkes, L, Parodi, C., Parzefall, F, Passeri, U, Passon, A, Pavel, O, Pegoraro, T, Peralta, M, Perepelitsa, L, Pernicka, V, Perrotta, M, Petridou, A, Petrolini, C, Philips, A, Piana, Ht, Piedra, G, Pieri, J, Pierre, L, Pimenta, F, Piotto, M, Podobnik, E, Poireau, T, Pol, V, Polok, Me, Polycarpo, G, Poropat, E, Pozdniakov, P, Privitera, V, Pukhaeva, R, Pullia, N, Radojicic, A, Ragazzi, D, Rahmani, S, Rakoczy, H, Rames, D, Ramler, J, Ratoff, L, Read, Pn, Rebecchi, A, Redaelli, P, Regler, Ng, Rehn, M, Reid, J, Reinhardt, D, Renton, R, Resvanis, P, Richard, Lk, Ridky, F, Rinaudo, J, Ripp, Baudot, Rivero, I, Rodriguez, M, Rohne, D, Romero, O, Ronchese, A, Rosenberg, P, Rosinsky, Ei, Roudeau, P, Rovelli, R, Royon, T, Ruhlmann, Kleider, Ruiz, V, Ryabtchikov, A, Saarikko, D, Sacquin, H, Sadovsky, Y, Sajot, A, Salmi, G, Salt, L, Sampsonidis, J, Sannino, D, Savoy, Navarro, Scheidle, A, Schneider, T, Schwemling, H, Schwering, P, Schwickerath, B, Schyns, U, Mae, Scuri, Seager, F, Sedykh, P, Segar, Y, Seibert, A, Sekulin, N, Shellard, R, Sheridan, Rc, Siebel, A, Silvestre, M, Simard, R, Simonetto, L, Sisakian, F, Skaali, A, Smadja, Tb, Smirnov, G, Smirnova, N, Smith, O, Sokolov, Gr, Sopczak, A, Sosnowski, A, Spassov, R, Spiriti, T, Sponholz, E, Squarcia, P, Stampfer, S, Stanescu, D, Stanic, C, Stanitzki, S, Stapnes, M, Stevenson, S, Stocchi, K, Strauss, A, Strub, J, Stugu, R, Szczekowski, B, Szeptycka, M, Szumlak, M, Tabarelli, T, Taffard, T, Tegenfeldt, Ac, Terranova, F, Thomas, F, Timmermans, J, Tinti, J, Tkatchev, N, Tobin, L, Todorov, M, Todorovova, T, Toet, S, Tomaradze, Dz, Tome, A, Tonazzo, B, Tortora, A, Tortosa, L, Transtromer, P, Travnicek, G, Treille, P, Tristram, D, Trochimczuk, G, Trombini, M, Troncon, A, Tsirou, C, Turluer, A, Tyapkin, Ml, Tyapkin, Ia, Tzamarias, P, Ullaland, S, Uvarov, O, Valenti, V, Vallazza, G, Vander, Velde, Van, Apeldoorn, Van, Dam, Van den Boeck, Van, Doninck, Van, Eldik, Van, Lysebetten, Van, Remortel, Van, Vulpen, Vassilopoulos, I, Vegni, N, Velos, G, Ventura, F, Venus, L, Verbeure, W, Verdier, F, Verlato, P, Vertogradov, M, Verzi, Ls, Vilanova, V, Vitale, D, Vlasov, L, Vodopyanov, E, Vollmer, As, Voulgaris, C, Vrba, G, Wahlen, V, Walck, H, Washbrook, C, Weiser, Aj, Wetherell, C, Wicke, Am, Wickens, D, Wilkinson, J, Winter, G, Witek, M, Wlodek, M, Yi, T, Yushchenko, J, Zaitsev, O, Zalewska, A, Zalewski, A, Zavrtanik, P, Zevgolatakos, D, Zhuravlov, E, Zimin, V, Zintchenko, Ni, Zoller, A, Zucchelli, P, Zumerle, Gc, Zupan, G, Acciarri, M, Achard, M, Adriani, P, O, Aguilar, Benitez, Alcaraz, M, Alemanni, J, Allaby, G, Aloisio, J, Alviggi, A, Ambrosi, Mg, Anderhub, G, Andreev, H, Angelescu, Vp, Anselmo, T, Arefiev, F, Azemoon, A, Aziz, T, Bagnaia, T, Bajo, P, Baksay, A, Baksay, G, Balandras, L, Baldew, A, Ball, Sv, Banerjee, Rc, Barczyk, S, Barillere, A, Barone, R, Bartalini, L, Basile, P, Batalova, M, Battiston, N, Bay, R, Becattini, A, Behner, F, Bellucci, F, Berbeco, L, Berdugo, R, Berges, J, Bertucci, P, Betev, B, Bhattacharya, Bl, Biasini, S, Biglietti, M, Biland, M, Blaising, A, Blyth, Jj, Bobbink, Sc, Bohm, Bj, Boldizsar, A, Borgia, L, Bottai, B, Bourilkov, S, Bourquin, D, Braccini, M, Branson, S, Brigljevic, Jg, Brochu, V, Brock, F, Buffini, Ic, Buijs, A, Burger, A, Burger, Jd, Button, Wj, Cai, A, Campanelli, Xd, Capell, M, Romeo, M, Carlino, Gc, Cartacci, G, Casaus, A, Castellini, J, Cavallari, G, Cavallo, E, Cecchi, N, Cerrada, C, Cesaroni, M, Chamizo, F, Chang, M, Chaturvedi, Yh, Chemarin, Uk, Chen, M, Chen, A, Chen, G, Chen, Gm, Chen, Hf, Chiefari, Hs, Cifarelli, G, Cindolo, L, Civinini, F, Clare, C, Clare, I, Coignet, R, Colijn, G, Colino, Ap, Costantini, N, Cotorobai, S, Cozzoni, F, de la Cruz, Csilling, B, Cucciarelli, A, Dai, S, Van, Dalen, Dalessandro, Ja, Asmundis, De, Debreczeni, R, Deglon, J, Degre, P, Dehmelt, P, Deiters, K, Della, Volpe, Delmeire, D, Denes, E, Denotaristefani, P, F, Salvo, De, Diemoz, A, Dierckxsens, M, Van, Dierendonck, Lodovico, Di, Dionisi, F, Dittmar, C, Dominguez, M, Doria, A, Dova, A, 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Thaler, Fe, Thom, Jj, Trandafir, J, Turk, Ai, Usher, Jd, Vavra, T, Vella, J, Venuti, E, Verdier, Jp, Wagner, R, Waite, Sr, Walston, Ap, Wang, S, Watts, J, Weidemann, Sj, Weiss, Aw, Whitaker, Er, White, Js, Wickens, Sl, Williams, Fj, Williams, Da, Williams, Dc, Willocq, Sh, Wilson, S, Wisniewski, Rj, Wittlin, Wj, Woods, Jl, Word, M, Wright, Gb, Wyss, Tr, Yamamoto, J, Yang, Rk, Yashima, Xq, Yellin, J, Young, Sj, Yuta, Cc, Zapalac, H, Zdarko, G, Zeitlin, Rw, Zhou, C, Blondel, Alain, Schael, S, Barate, R, Bruneliere, R, Spagnolo, Stefania Antonia, S., Schael, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Napolitano, Marco, Patricelli, Sergio, Sciacca, Crisostomo, Lista, Luca, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALEPH, DELPHI, L3, OPAL, SLD, BARBIELLINI AMIDEI, Guido, Bosisio, Luciano, DELLA RICCA, Giuseppe, Giannini, Gianrossano, Gregorio, Anna, Lanceri, Livio, Poropat, Paolo, Vitale, Lorenzo, Buskulic, D, De Bonis, I, Decamp, D, Ghez, P, Goy, C, Jezequel, S, Lees, J, Lucotte, A, Martin, F, Merle, E, Minard, M, Nief, J, Odier, P, Pietrzyk, B, Trocme, B, Bravo, S, Casado, M, Chmeissani, M, Comas, P, Crespo, J, Fernandez, E, Fernandez Bosman, M, Garrido, L, Grauges, E, Juste, A, Martinez, M, Merino, G, Miquel, R, Mir, L, Orteu, S, Pacheco, A, Park, I, Perlas, J, Riu, I, Ruiz, H, Sanchez, F, Colaleo, A, Creanza, D, De Filippis, N, De Palma, M, Iaselli, G, Maggi, G, Maggi, M, Nuzzo, S, Ranieri, A, Raso, G, Ruggieri, F, Selvaggi, G, Silvestris, L, Tempesta, P, Tricomi, A, Zito, G, Huang, X, Lin, J, Ouyang, Q, Wang, T, Xie, Y, Xu, R, Xue, S, Zhang, J, Zhang, L, Zhao, W, Abbaneo, D, Bazarko, A, Becker, U, Boix, G, Bird, F, Blucher, E, Bonvicini, B, Bright Thomas, P, Barklow, T, Buchmuller, O, Cattaneo, M, Cerutti, F, Ciulli, V, Clerbaux, B, Drevermann, H, Forty, R, Frank, M, Greening, T, Hagelberg, R, Halley, A, Gianotti, F, Girone, M, Hansen, J, Harvey, J, Jacobsen, R, Hutchcroft, D, Janot, R, Jost, B, Knobloch, J, Kado, M, Lehraus, I, Lazeyras, P, Maley, R, Mato, P, May, J, Moutussi, A, Pepe Altarelli, M, Ranjard, F, Rolandi, L, Schlatter, D, Schmitt, B, Schneider, O, Tejessy, W, Teubert, F, Tomalin, I, Tournefier, E, Veenhof, R, Valassi, A, Wiedenmann, W, Wright, A, Ajaltouni, Z, Badaud, F, Chazelle, G, Deschamps, O, Dessagne, S, Falvard, A, Ferdi, C, Fayolle, D, Gay, P, Guicheney, C, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, J, Pallin, D, Pascolo, J, Perret, P, Podlyski, F, Bertelsen, H, Fernley, T, Hansen, P, Kraan, A, Lindahl, A, Mollerud, R, Nilsson, B, Rensch, B, Waananen, A, Daskalakis, G, Kyriakis, A, Markou, C, Simopoulou, E, Siotis, I, Vayaki, A, Zachariadou, K, Blondel, A, Bonneaud, G, Brient, J, Machefert, E, Rouge, A, Rumpf, M, Swynghedauw, M, Tanaka, R, Verderi, M, Videau, H, Focardi, E, Parrini, G, Corden, M, Georgiopoulos, C, Antonelli, A, Antonelli, M, Bencivenni, G, Bologna, G, Bossi, F, Campana, P, Capon, G, Chiarella, V, Felici, G, Laurelli, P, Mannocchi, G, Murtas, G, Passalacqua, L, Picchi, P, Colrain, P, Ten Have, I, Hughes, I, Kennedy, J, Knowles, I, Lynch, J, Morton, W, Negus, P, O'Shea, V, Raine, C, Reeves, P, Scarr, J, Smith, K, Thompson, A, Turnbull, R, Wasserbaech, S, Cavanaugh, R, Dhamotharan, S, Geweniger, C, Hanke, P, Hansper, G, Hepp, V, Kluge, E, Putzer, A, Sommer, J, Stenzel, H, Tittel, K, Werner, W, Wunsch, M, Beuselinck, R, Binnie, D, Cameron, W, Davies, G, Dornan, P, Goodsir, S, Marinelli, N, Martin, E, Nash, J, Nowell, J, Rutherford, S, Sedgbeer, J, Thompson, J, White, R, Williams, M, Ghete, V, Girtler, P, Kneringer, E, Kuhn, D, Rudolph, G, Bouhova Thacker, E, Bowdery, C, Buck, P, Clarke, D, Ellis, G, Finch, A, Foster, F, Hughes, G, Jones, R, Keemer, N, Pearson, M, Robertson, N, Sloan, T, Smizanska, M, Snow, S, Van Der Aa, O, Delaere, C, Leibenguth, G, Lemaitre, V, Bauerdick, L, Blumenschein, U, Van Gemmeren, P, Giehl, I, Holldorfer, F, Jakobs, K, Kasemann, M, Kayser, F, Kleinknecht, K, Muller, A, Quast, G, Renk, B, Rohne, E, Sander, H, Schmeling, S, Wachsmuth, H, Wanke, R, Zeitnitz, C, Ziegler, T, Aubert, J, Benchouk, C, Bonissent, A, Carr, J, 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Vandalen, Gj, Virtue, Cj, Vokurka, Eh, Vollmer, Cf, Wagner, Dl, Walker, Jp, Ward, Cp, Ward, Dr, Watkins, Pm, Watson, At, Watson, Nk, Whalley, Ma, Wilson, Ja, Wilson, Gw, Winterer, Vh, Wood, Nc, Wyatt, Tr, Zorn, Gt, Allen, Nj, Ash, Ww, Baird, Kg, Band, Hr, Barakat, Mb, Baranko, Gj, Barklow, Tl, Bashindzhagian, Gl, Bauer, Jm, Bazarko, Ao, Benvenuti, Ac, Bilei, Gm, Bower, Gr, Brau, Je, Bugg, Wm, Burnett, Th, Burrows, Pn, Caldwell, Do, Chadwick, Gb, Cohn, Ho, Coller, Ja, Convery, Mr, Cowan, Rf, Coyle, Pa, Coyne, Dg, Damerell, Cj, de Groot, N, de Sangro, R, Dervan, Pj, Dong, Dn, Du, Pyc, Eisenstein, Bi, Fernandez, Jp, Fero, Mj, Friedman, Ji, Garwin, El, Hallewell, Gd, Hart, El, Hitlin, Dg, Huffer, Me, Hughes, Ew, Izen, Jm, Jackson, Dj, Jaros, Ja, Jiang, Zy, Johnson, Jr, Johnson, Ra, Kamyshkov, Ya, Kang, Hj, Kelsey, Mh, Kendall, Hw, Kim, Yd, Krishna, Nm, Labs, Jf, Lauber, Ja, Leith, Dwg, Liu, Mx, Lynch, Hl, Markiewicz, Tw, Mcgowan, Jf, Mckemey, Ak, Meadows, Bt, Mockett, Pm, Moffeit, Kc, 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MCGOWAN, A.K. MCKEMEY, B.T. MEADOWS, R. MESSNER, P.M. MOCKETT, K.C. MOFFEIT, T.B. MOORE, M. MORII, B. MOURS, D. MULLER, G. MUELLER, V. MURZIN, T. NAGAMINE, S. NARITA, U. NAUENBERG, H. NEAL, G. NESOM, M. NUSSBAUM, Y. OHNISHI, N. OISHI, D. ONOPRIENKO, L.S. OSBORNE, R.S. PANVINI, C.H.PARK, H. PARK, T.J. PAVEL, I. PERUZZI, L. PESCARA, M. PICCOLO, L. PIEMONTESE, E. PIERONI, K.T. PITTS, R.J. PLANO, R. PREPOST, C.Y. PRESCOTT, G. PUNKAR, J. QUIGLEY, B.N. RATCLIFF, K. REEVES, T.W. REEVES, J. REIDY, P.L. REINERTSEN, P.E. RENSING, L.S. ROCHESTER, J.E. ROTHBERG, P.C. ROWSON, J.J. RUSSELL, O.H. SAXTON, T. SCHALK, R.H. SCHINDLER, U. SCHNEEKLOTH, B.A. SCHUMM, J. SCHWIENING, A. SEIDEN, S. SEN, V.V. SERBO, L. SERVOLI, M.H. SHAEVITZ, J.T. SHANK, G. SHAPIRO, D.J. SHERDEN, K.D. SHMAKOV, C. SIMOPOULOS, N.B. SINEV, S.R. SMITH, M.B. SMY, J.A. SNYDER, M.D. SOKOLOFF, H. STAENGLE, A. STAHL, P. STAMER, H. STEINER, R. STEINER, M.G. STRAUSS, D. SU, F. SUEKANE, A. SUGIYAMA, A. SUZUKI, S. SUZUKI, M. SWARTZ, A. SZUMILO, T. TAKAHASHI, F.E. TAYLOR, J.J. THALER, J. THOM, E. TORRENCE, A.I. TRANDAFIR, J.D. TURK, T. USHER, J. VA VRA, C. VANNINI, E. VELLA, J.P. VENUTI, R. VERDIER, P.G. VERDINI, D.L. WAGNER, S.R. WAGNER, A.P. WAITE, S. WALSTON, J. WANG, S.J. WATTS, A.W. WEIDEMANN, E.R. WEISS, J.S. WHITAKER, S.L. WHITE, F.J. WICKENS, D.A. WILLIAMS, D.C. WILLIAMS, S.H. WILLIAMS, S. WILLOCQ, R.J. WILSON, W.J. WISNIEWSKI, J.L. WITTLIN, M. WOODS, G.B. WORD, T.R. WRIGHT, J. WYSS, R.K. YAMAMOTO, J.M. YAMARTINO, X.Q. YANG, J. YASHIMA, S.J. YELLIN, C.C.YOUNG, H.YUTA, G. ZAPALAC, R.W. ZDARKO, C. ZEITLIN, J. ZHOU, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), GRUNEVALD M, NEWALD M, SCHAEL S, BARATE R, BRUNELIE, RE R, BUSKULIC D, DE BONIS I, DECAMP D, GHEZ P, GOY C, JE, ZE, QUEL S, LEES J, LUCOTTE A, MARTIN M, MERLE E, MINARD M, NIEF J, ODIER P, PIETRZYK B, TROCME, BRAVO S, CASADO MP, CHMEISSANI M, COMAS P, CRESPO JM, FERNANDEZ E, FERNANDEZ-BOSMAN M, GARRIDO L, GRAUGES E, JUSTE A, MARTINEZ M, MERINO G, MIQUEL R, MIR LM, ORTEU S, PACHECO A, PARK IC, PERLAS J, RIU I, RUIZ H, SANCHEZ F, COLALEO A, CREANZA D, DE FILIPPIS N, DE PALMA M, IASELLI G, MAGGI G, MAGGI M, NUZZO S, RANIERI, A, RASO, G, RUGGIERI F, SELVAGGI, G, SILVESTRIS L, TEMPESTA P, TRICOMI A, ZITO G, HUANG X, LIN J, OUYANG Q, WANG T, XIE Y, XU R, XUE S, ZHANG J, ZHANG L, ZHAO W, ABBANEO D, BAZARKO A, BECKER U, BOIX G, BIRD F, BLUCHER E, BONVICINI B, BRIGHT-THOMAS P, BARKLOW T, BUCHMU, LLER O, CATTANEO M, CERUTTI F, CIULLI V, CLERBAUX B, DREVERMANN H, FORTY RW, FRANK M, GREENING TC, HAGELBERG R, HALLEY AW, GIANOTTI F, GIRONE M, HANSEN JB, HARVEY J, JACOBSEN J, HUTCHCROFT DE, JANOT P, JOST B, KNOBLOCH J, KADO M, LEHRAUS I, LAZEYRAS P, and MALEY P
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Top quark ,FORWARD-BACKWARD ASYMMETRY ,PARTICLE PHYSICS ,LARGE ELECTRON POSITRON COLLIDER ,ALEPH ,DELPHI ,L3 ,OPAL ,General Physics and Astronomy ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,Settore FIS/04 - Fisica Nucleare e Subnucleare ,High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology (hep-ph) ,electron-positron physics ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Electroweak interaction ,Physics ,Quantum chromodynamics ,Electron–positron physics ,Electroweak interactions ,Decays of heavy intermediate gauge bosons ,Fermion–antifermion production ,Precision measurements at the Z resonance ,Tests of the Standard Model ,Radiative corrections ,Effective coupling constants ,Neutral weak current ,Z boson ,W boson ,Higgs boson ,Particle physics - Experiment ,Settore FIS/01 - Fisica Sperimentale ,FERMION-PAIR PRODUCTION ,HADRONIC-Z-DECAYS ,TOP-QUARK MASS ,ANGLE BHABHA SCATTERING ,W-BOSON MASS ,CROSS-SECTION ASYMMETRY ,Z-LINE-SHAPE ,SEMILEPTONIC BRANCHING RATIOS ,CARLO EVENT GENERATOR ,decays of heavy intermediate gauge bosons ,effective coupling constants ,electroweak interactions ,fermion-antifermion production ,higgs boson ,neutral weak current ,precision measurements at the z resonance ,radiative corrections ,tests of the standard model ,top quark ,w boson ,z boson ,Radiative correction ,High Energy Physics - Phenomenology ,FIS/01 - FISICA SPERIMENTALE ,Física nuclear ,Neutrino ,Particle physics ,FOS: Physical sciences ,ddc:500.2 ,Elementary particle physics ,LEP ,electroweak ,Decays of heavy intermediate gauge boson ,Effective coupling constant ,Partícules (Física nuclear) ,Standard Model ,electroweak theory, Z boson, DELPHI, ALEPH, OPAL, L3 ,0103 physical sciences ,010306 general physics ,Coupling constant ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,Fermion ,FORWARD-BACKWARD ASYMMETRY, FERMION-PAIR PRODUCTION, HADRONIC-Z-DECAYS, TOP-QUARK MASS, ANGLE BHABHA SCATTERING, W-BOSON MASS, CROSS-SECTION ASYMMETRY, Z-LINE-SHAPE, SEMILEPTONIC BRANCHING RATIOS, CARLO EVENT GENERATOR ,[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph] ,Experimental High Energy Physics ,Electron–positron physic ,High Energy Physics::Experiment ,FIS/04 - FISICA NUCLEARE E SUBNUCLEARE - Abstract
We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $\MZ$ and $\GZ$, and its couplings to fermions, for example the $\rho$ parameter and the effective electroweak mixing angle, are precisely measured. The number of light neutrino species is determined to be 2.9840+/-0.0082. The results are compared to the predictions of the Standard Model. Electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its Standard Model expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the masses of the top quark and the W Boson are predicted. These indirect constraints are compared to the direct measurements, providing a stringent test of the Standard Model. Using in addition the direct measurements of $\Mt$ and $\MW$, the mass of the as yet unobserved Standard Model Higgs boson is predicted., Comment: 302 pages, v2: minor corrections and updates of references. Accepted for publication by Physics Reports, v3: further small corrections and journal version
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- 2006
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205. Zur Minderung der Ototoxizität und Nephrotoxizität des Tobramycins
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Federspil, P., Schätzte, W., Kayser, M., and Sack, K.
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- 1979
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206. The Effective Mutation Rate at Y Chromosome Short Tandem Repeats, with Application to Human Population-Divergence Time
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Zhivotovsky, L. A., Underhill, P. A., Cinnioglu, C., Kayser, M., Morar, B., Kivisild, T., Scozzari, Rosaria, Cruciani, Fulvio, DESTRO-BISOL, Giovanni, Giovanni Destro Bisol, Spedini, G., Chambers, G. K., Herrera, R. J., Yong, K. K., Gresham, D., Tournev, I., Feldman, M. W., and Kalaydjieva, L.
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Male ,Mutation rate ,Human Y-chromosome DNA haplogroup ,Population ,Locus (genetics) ,Biology ,Y chromosome ,Haplogroup ,Polynesia ,White People ,03 medical and health sciences ,Genetics ,Humans ,Genetics(clinical) ,microsateliltes ,education ,Y-SNP ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,education.field_of_study ,Chromosomes, Human, Y ,Models, Genetic ,030305 genetics & heredity ,Chromosome Mapping ,Genetic Variation ,Articles ,Tandem Repeat Sequences ,Mutation ,y chromosome ,Microsatellite ,Female ,New Zealand - Abstract
We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9×10 −4 per 25 years, with a standard deviation across loci of 5.7×10 −4 , using data on microsatellite variation within Y chromosome haplogroups defined by unique-event polymorphisms in populations with documented short-term histories, as well as comparative data on worldwide populations at both the Y chromosome and various autosomal loci. This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria.
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- 2004
207. Der Einfluß der Urämie auf Arzneimittel abbauende Enzyme in Rattenlebermikrosomen
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Leber, H. W., Streitzig, P., Kayser, M., and Schütterle, G.
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- 1971
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208. Synthesis of Chondroitin Sulfate Oligosaccharides Using N‐(Tetrachlorophthaloyl)‐ and N‐(Trifluoroacetyl)galactosamine Building Blocks
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Macchione, Giuseppe, primary, Maza, Susana, additional, Mar Kayser, M., additional, de Paz, José L., additional, and Nieto, Pedro M., additional
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- 2014
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209. Biological Computation for Digital Design and Fabrication: A biologically-informed finite element approach to structural performance and material optimization of robotically deposited fibre structures
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Oxman, N. (author), Laucks, J. (author), Kayser, M. (author), Uribe, C.D.G. (author), Duro-Royo, J. (author), Oxman, N. (author), Laucks, J. (author), Kayser, M. (author), Uribe, C.D.G. (author), and Duro-Royo, J. (author)
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The formation of non-woven fibre structures generated by the Bombyx mori silkworm is explored as a computational approach for shape and material optimization. Biological case studies are presented and a design approach for the use of silkworms as entities that can compute fibrous material organization is given in the context of an architectural design installation. We demonstrate that in the absence of vertical axes the silkworm can spin flat silk patches of variable shape and density. We present experiments suggesting sufficient correlation between topographical surface features, spinning geometry and fibre density. The research represents a scalable approach for optimization-driven fibre-based structural design and suggests a biology-driven strategy for material computation.
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- 2013
210. Colorful DNA polymorphisms in humans
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Liu, F., Wen, B., Kayser, M., Liu, F., Wen, B., and Kayser, M.
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- 2013
211. Challenge in Focus: Financial and Fiscal Governance
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Hertie School of Governance, Berlin, Anheier, Helmut, Hallerberg, Mark, Kaul, Inge, Kayser, Mark, Hertie School of Governance, B ( Berlin ), Anheier, H ( Helmut ), Hallerberg, M ( Mark ), Kaul, I ( Inge ), Kayser, M ( Mark ), Clark, William Roberts, Copelovitch, Mark, Quagliata, Lucia, Walter, Stefanie, Hertie School of Governance, Berlin, Anheier, Helmut, Hallerberg, Mark, Kaul, Inge, Kayser, Mark, Hertie School of Governance, B ( Berlin ), Anheier, H ( Helmut ), Hallerberg, M ( Mark ), Kaul, I ( Inge ), Kayser, M ( Mark ), Clark, William Roberts, Copelovitch, Mark, Quagliata, Lucia, and Walter, Stefanie
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- 2013
212. Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization
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Maza, Susana, Kayser, M. Mar, Macchione, Giuseppe, López-Prados, Javier, Angulo, Jesús, Paz, José L. de, Nieto, Pedro M., Maza, Susana, Kayser, M. Mar, Macchione, Giuseppe, López-Prados, Javier, Angulo, Jesús, Paz, José L. de, and Nieto, Pedro M.
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Here, we present a novel approach for the chemical synthesis of chondroitin and dermatan sulfate oligosaccharides. A key point of this strategy is the preparation and use of an N-trifluoroacetyl galactosamine building block containing a 4,6-O-di-tert-butylsilylene group. Glycosylation reactions proceeded in good yields (74-91%) with our protecting group distribution. Using this approach, we have synthesized, for the first time, a chondroitin/dermatan sulfate-like tetrasaccharide that contains both types of uronic acids, d-glucuronic and l-iduronic acid. Moreover, we have employed a fluorescence polarization competition assay to evaluate the interactions between the synthesized oligosaccharides and FGF-2 (basic fibroblast growth factor). Our results show that this method, using standard instrumentation and minimal sample consumption, is a powerful tool for the rapid analysis of the glycosaminoglycan affinity for proteins in solution. This journal is © The Royal Society of Chemistry.
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- 2013
213. Reconstructing the Population History of European Romani from Genome-wide Data
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Mendizabal, I., Lao, O., Marigorta, U.M., Wollstein, A., Gusmao, L., Ferak, V., Ioana, M., Jordanova, A., Kaneva, R., Kouvatsi, A., Kucinskas, V., Makukh, H., Metspalu, A., Netea, M.G., de Pablo, R., Pamjav, H., Radojkovic, D., Rolleston, S.J., Sertic, J., Macek, M., Jr., Comas, D., Kayser, M., Mendizabal, I., Lao, O., Marigorta, U.M., Wollstein, A., Gusmao, L., Ferak, V., Ioana, M., Jordanova, A., Kaneva, R., Kouvatsi, A., Kucinskas, V., Makukh, H., Metspalu, A., Netea, M.G., de Pablo, R., Pamjav, H., Radojkovic, D., Rolleston, S.J., Sertic, J., Macek, M., Jr., Comas, D., and Kayser, M.
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Item does not contain fulltext, The Romani, the largest European minority group with approximately 11 million people [1], constitute a mosaic of languages, religions, and lifestyles while sharing a distinct social heritage. Linguistic [2] and genetic [3-8] studies have located the Romani origins in the Indian subcontinent. However, a genome-wide perspective on Romani origins and population substructure, as well as a detailed reconstruction of their demographic history, has yet to be provided. Our analyses based on genome-wide data from 13 Romani groups collected across Europe suggest that the Romani diaspora constitutes a single initial founder population that originated in north/northwestern India approximately 1.5 thousand years ago (kya). Our results further indicate that after a rapid migration with moderate gene flow from the Near or Middle East, the European spread of the Romani people was via the Balkans starting approximately 0.9 kya. The strong population substructure and high levels of homozygosity we found in the European Romani are in line with genetic isolation as well as differential gene flow in time and space with non-Romani Europeans. Overall, our genome-wide study sheds new light on the origins and demographic history of European Romani.
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- 2012
214. Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
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Raimondi, S, Gandini, S, Fargnoli, MC, Bagnardi, V, Maisonneuve, P, Specchia, C, Kumar, R, Nagore, E, Han, J, Hansson, J, Kanetsky, PA, Ghiorzo, P, Gruis, NA, Dwyer, T, Blizzard, L, Fernandez-de-Misa, R, Branicki, W, Debniak, T, Morling, N, Landi, MT, Palmieri, G, Ribas, G, Stratigos, A, Cornelius, L, Motokawa, T, Anno, S, Helsing, P, Wong, TH, Autier, P, Garcia-Borron, JC, Little, J, Newton-Bishop, J, Sera, F, Liu, F, Kayser, M, Nijsten, T, Raimondi, S, Gandini, S, Fargnoli, MC, Bagnardi, V, Maisonneuve, P, Specchia, C, Kumar, R, Nagore, E, Han, J, Hansson, J, Kanetsky, PA, Ghiorzo, P, Gruis, NA, Dwyer, T, Blizzard, L, Fernandez-de-Misa, R, Branicki, W, Debniak, T, Morling, N, Landi, MT, Palmieri, G, Ribas, G, Stratigos, A, Cornelius, L, Motokawa, T, Anno, S, Helsing, P, Wong, TH, Autier, P, Garcia-Borron, JC, Little, J, Newton-Bishop, J, Sera, F, Liu, F, Kayser, M, and Nijsten, T
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BACKGROUND: For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease. Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia. DESIGN AND METHODS: Based on our experience with the study design of the Melanocortin-1 receptor (MC1R) gene, SKin cancer and Phenotypic characteristics (M-SKIP) project, we describe the most important steps in planning and conducting a pooled-analysis of genetic epidemiological studies. We then present the statistical analysis plan that we are going to apply, giving particular attention to methods of analysis recently proposed to account for between-study heterogeneity and to explore the joint contribution of genetic, phenotypic and environmental factors in the development of a disease. Within the M-SKIP project, data on 10,959 skin cancer cases and 14,785 controls from 31 international investigators were checked for quality and recoded for standardization. We first proposed to fit the aggregated data with random-effects logistic regression models. However, for the M-SKIP project, a two-stage analysis will be preferred to overcome the problem regarding the availability of different study covariates. The joint contribution of MC1R variants and phenotypic characteristics to skin cancer development will be studied via logic regression modeling. DISCUSSION: Methodological guidelines to correctly design and conduct pooled-analyses are needed to facilitate application of such methods, thus providing a better summary of the actual findings on specific fields.
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- 2012
215. The Q2 mitochondrial haplogroup in Oceania.
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Kayser, M, Corser, CA, McLenachan, PA, Pierson, MJ, Harrison, GLA, Penny, D, Kayser, M, Corser, CA, McLenachan, PA, Pierson, MJ, Harrison, GLA, and Penny, D
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Many details surrounding the origins of the peoples of Oceania remain to be resolved, and as a step towards this we report seven new complete mitochondrial genomes from the Q2a haplogroup, from Papua New Guinea, Fiji and Kiribati. This brings the total to eleven Q2 genomes now available. The Q haplogroup (that includes Q2) is an old and diverse lineage in Near Oceania, and is reasonably common; within our sample set of 430, 97 are of the Q haplogroup. However, only 8 are Q2, and we report 7 here. The tree with all complete Q genomes is proven to be minimal. The dating estimate for the origin of Q2 (around 35 Kya) reinforces the understanding that humans have been in Near Oceania for tens of thousands of years; nevertheless the Polynesian maternal haplogroups remain distinctive. A major focus now, with regard to Polynesian ancestry, is to address the differences and timing of the 'Melanesian' contribution to the maternal and paternal lineages as people moved further and further into Remote Oceania. Input from other fields such as anthropology, history and linguistics is required for a better understanding and interpretation of the genetic data.
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- 2012
216. Melanocortin-1receptor, skincancer and phenotypic characteristics (MSKIP) project: study design and methods for pooling results of genetic epidemiological studies.
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Raimondi, S., Gandini, S., Fargnoli, M.C., Bagnardi, V., Maissonneuve, P., Specchia, C., Kumar, R., Nagore, E., Han, J., Hansson, J., Kanetsky, P.A., Ghiorzo, P., Gruis, N.A., Dwyer, T., Blizzard, L., Fernandez-de-Misa, R., Brainicki, W., Debniak, T., Landi, M.T., Morling, Niels, Palmieri, G., Ribas, G., Stratigos, A., Cornelius, L., Motokawa, T., Anno, S., Helsing, P., Wong, T.H., Autier, P., Garcia-Borron, J.C., Little, J., Newton-Bishop, J., Liu, F., Kayser, M., Nijsten, T., Raimondi, S., Gandini, S., Fargnoli, M.C., Bagnardi, V., Maissonneuve, P., Specchia, C., Kumar, R., Nagore, E., Han, J., Hansson, J., Kanetsky, P.A., Ghiorzo, P., Gruis, N.A., Dwyer, T., Blizzard, L., Fernandez-de-Misa, R., Brainicki, W., Debniak, T., Landi, M.T., Morling, Niels, Palmieri, G., Ribas, G., Stratigos, A., Cornelius, L., Motokawa, T., Anno, S., Helsing, P., Wong, T.H., Autier, P., Garcia-Borron, J.C., Little, J., Newton-Bishop, J., Liu, F., Kayser, M., and Nijsten, T.
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- 2012
217. Y-chromosomal diversity within Europe is clinal and influenced primarily by geography rather than language
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Rosser, Z. H., Zerjal, T., Hurles, M. E., Adojaan, M., Alavantic, D., Amorim, A., Amos, W., Armenteros, M., Arroyo, E., Barbujani, Guido, Beckman, L., BERTRANPETIT J., Bosch E., Bradley, D. G., Brede, G., Cooper, G., Corte Real, H. B. S. M., de Knijff, P., Decorte, R., Dubrova, Y. E., Evgrafov, O., Gilissen, A, Glisic, S., Golge, M, Hill, E. W., Jeziorowska, A, Kalaydjieva, L, Kayser, M, Kivisild, T, Kravchenko, S., Krumina, A, Kucinskas, V, Lavinha, J, Livshits, L. A., Malaspina, P, Syrrou, M, Mcelreavey, K, Meitinger, Ta, Mikelsaar, Av, Mitchell, Rj, Nafa, K, Nicholson, J, Nørby, S, Pandya, A, Parik, J, Patsalis, Pc, Pereira, L, Peterlin, B, Pielberg, G, Prata, Mj, Previderè, C, Roewer, L, Rootsi, S, Rubinsztein, Dc, Saillard, J, Santos, Fr, Stefanescu, G, Sykes, Bc, Tolun, A, Villems, R, Tyler Smith, C, and Jobling, Ma
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- 2000
218. Homocysteine and Familial Longevity: The Leiden Longevity Study
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Kayser, M, Wijsman, CA, van Heemst, D, Rozing, MP, Slagboom, PE, Beekman, M, de Craen, AJM, Maier, AB, Westendorp, RGJ, Blom, HJ, Mooijaart, SP, Kayser, M, Wijsman, CA, van Heemst, D, Rozing, MP, Slagboom, PE, Beekman, M, de Craen, AJM, Maier, AB, Westendorp, RGJ, Blom, HJ, and Mooijaart, SP
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Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity. We measured concentrations of total homocysteine in 1907 subjects from the Leiden Longevity Study consisting of 1309 offspring of nonagenarian siblings, who are enriched with familial factors promoting longevity, and 598 partners thereof as population controls. We found that homocysteine was related to age, creatinine, folate, vitamin B levels and medical history of hypertension and stroke in both groups (all p<0.001). However, levels of homocysteine did not differ between offspring enriched for longevity and their partners, and no differences in the age-related rise in homocysteine levels were found between groups (p for interaction 0.63). The results suggest that homocysteine metabolism is not likely to predict familial longevity.
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- 2011
219. Energie- und Emissionsbilanzen der Geothermieanlagen Neustadt-Glewe und Riehen
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Kayser, M., Kaltschmitt, M., and 4.1 Reservoir Technologies, 4.0 Chemistry and Material Cycles, Departments, GFZ Publication Database, Deutsches GeoForschungsZentrum
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550 - Earth sciences - Published
- 1999
220. Digital Quantification of Human Eye Color Highlights Genetic Association of Three New Loci
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McCarthy, MI, Liu, F, Wollstein, A, Hysi, PG, Ankra-Badu, GA, Spector, TD, Park, D, Zhu, G, Larsson, M, Duffy, DL, Montgomery, GW, Mackey, DA, Walsh, S, Lao, O, Hofman, A, Rivadeneira, F, Vingerling, JR, Uitterlinden, AG, Martin, NG, Hammond, CJ, Kayser, M, McCarthy, MI, Liu, F, Wollstein, A, Hysi, PG, Ankra-Badu, GA, Spector, TD, Park, D, Zhu, G, Larsson, M, Duffy, DL, Montgomery, GW, Mackey, DA, Walsh, S, Lao, O, Hofman, A, Rivadeneira, F, Vingerling, JR, Uitterlinden, AG, Martin, NG, Hammond, CJ, and Kayser, M
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Previous studies have successfully identified genetic variants in several genes associated with human iris (eye) color; however, they all used simplified categorical trait information. Here, we quantified continuous eye color variation into hue and saturation values using high-resolution digital full-eye photographs and conducted a genome-wide association study on 5,951 Dutch Europeans from the Rotterdam Study. Three new regions, 1q42.3, 17q25.3, and 21q22.13, were highlighted meeting the criterion for genome-wide statistically significant association. The latter two loci were replicated in 2,261 individuals from the UK and in 1,282 from Australia. The LYST gene at 1q42.3 and the DSCR9 gene at 21q22.13 serve as promising functional candidates. A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits.
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- 2010
221. Hundreds of variants clustered in genomic loci and biological pathways affect human height
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Allen, HL, Estrada, K, Lettre, G, Berndt, SI, Weedon, MN, Rivadeneira, F, Willer, CJ, Jackson, AU, Vedantam, S, Raychaudhuri, S, Ferreira, T, Wood, AR, Weyant, RJ, Segre, AV, Speliotes, EK, Wheeler, E, Soranzo, N, Park, J-H, Yang, J, Gudbjartsson, D, Heard-Costa, NL, Randall, JC, Qi, L, Smith, AV, Maegi, R, Pastinen, T, Liang, L, Heid, IM, Luan, J, Thorleifsson, G, Winkler, TW, Goddard, ME, Lo, KS, Palmer, C, Workalemahu, T, Aulchenko, YS, Johansson, A, Zillikens, MC, Feitosa, MF, Esko, T, Johnson, T, Ketkar, S, Kraft, P, Mangino, M, Prokopenko, I, Absher, D, Albrecht, E, Ernst, F, Glazer, NL, Hayward, C, Hottenga, J-J, Jacobs, KB, Knowles, JW, Kutalik, Z, Monda, KL, Polasek, O, Preuss, M, Rayner, NW, Robertson, NR, Steinthorsdottir, V, Tyrer, JP, Voight, BF, Wiklund, F, Xu, J, Zhao, JH, Nyholt, DR, Pellikka, N, Perola, M, Perry, JRB, Surakka, I, Tammesoo, M-L, Altmaier, EL, Amin, N, Aspelund, T, Bhangale, T, Boucher, G, Chasman, DI, Chen, C, Coin, L, Cooper, MN, Dixon, AL, Gibson, Q, Grundberg, E, Hao, K, Junttila, MJ, Kaplan, LM, Kettunen, J, Koenig, IR, Kwan, T, Lawrence, RW, Levinson, DF, Lorentzon, M, McKnight, B, Morris, AP, Mueller, M, Ngwa, JS, Purcell, S, Rafelt, S, Salem, RM, Salvi, E, Sanna, S, Shi, J, Sovio, U, Thompson, JR, Turchin, MC, Vandenput, L, Verlaan, DJ, Vitart, V, White, CC, Ziegler, A, Almgren, P, Balmforth, AJ, Campbell, H, Citterio, L, De Grandi, A, Dominiczak, A, Duan, J, Elliott, P, Elosua, R, Eriksson, JG, Freimer, NB, Geus, EJC, Glorioso, N, Haiqing, S, Hartikainen, A-L, Havulinna, AS, Hicks, AA, Hui, J, Igl, W, Illig, T, Jula, A, Kajantie, E, Kilpelaeinen, TO, Koiranen, M, Kolcic, I, Koskinen, S, Kovacs, P, Laitinen, J, Liu, J, Lokki, M-L, Marusic, A, Maschio, A, Meitinger, T, Mulas, A, Pare, G, Parker, AN, Peden, JF, Petersmann, A, Pichler, I, Pietilainen, KH, Pouta, A, Riddertrale, M, Rotter, JI, Sambrook, JG, Sanders, AR, Schmidt, CO, Sinisalo, J, Smit, JH, Stringham, HM, Walters, GB, Widen, E, Wild, SH, Willemsen, G, Zagato, L, Zgaga, L, Zitting, P, Alavere, H, Farrall, M, McArdle, WL, Nelis, M, Peters, MJ, Ripatti, S, vVan Meurs, JBJ, Aben, KK, Ardlie, KG, Beckmann, JS, Beilby, JP, Bergman, RN, Bergmann, S, Collins, FS, Cusi, D, den Heijer, M, Eiriksdottir, G, Gejman, PV, Hall, AS, Hamsten, A, Huikuri, HV, Iribarren, C, Kahonen, M, Kaprio, J, Kathiresan, S, Kiemeney, L, Kocher, T, Launer, LJ, Lehtimaki, T, Melander, O, Mosley, TH, Musk, AW, Nieminen, MS, O'Donnell, CJ, Ohlsson, C, Oostra, B, Palmer, LJ, Raitakari, O, Ridker, PM, Rioux, JD, Rissanen, A, Rivolta, C, Schunkert, H, Shuldiner, AR, Siscovick, DS, Stumvoll, M, Toenjes, A, Tuomilehto, J, van Ommen, G-J, Viikari, J, Heath, AC, Martin, NG, Montgomery, GW, Province, MA, Kayser, M, Arnold, AM, Atwood, LD, Boerwinkle, E, Chanock, SJ, Deloukas, P, Gieger, C, Gronberg, H, Hall, P, Hattersley, AT, Hengstenberg, C, Hoffman, W, Lathrop, GM, Salomaa, V, Schreiber, S, Uda, M, Waterworth, D, Wright, AF, Assimes, TL, Barroso, I, Hofman, A, Mohlke, KL, Boomsma, DI, Caulfield, MJ, Cupples, LA, Erdmann, J, Fox, CS, Gudnason, V, Gyllensten, U, Harris, TB, Hayes, RB, Jarvelin, M-R, Mooser, V, Munroe, PB, Ouwehand, WH, Penninx, BW, Pramstaller, PP, Quertermous, T, Rudan, I, Samani, NJ, Spector, TD, Voelzke, H, Watkins, H, Wilson, JF, Groop, LC, Haritunians, T, Hu, FB, Kaplan, RC, Metspalu, A, North, KE, Schlessinger, D, Wareham, NJ, Hunter, DJ, O'Connell, JR, Strachan, DP, Schadt, H-E, Thorsteinsdottir, U, Peltonen, L, Uitterlinden, AG, Visscher, PM, Chatterjee, N, Loos, RJF, Boehnke, M, McCarthy, MI, Ingelsson, E, Lindgren, CM, Abecasis, GR, Stefansson, K, Frayling, TM, Hirschhorn, JN, Allen, HL, Estrada, K, Lettre, G, Berndt, SI, Weedon, MN, Rivadeneira, F, Willer, CJ, Jackson, AU, Vedantam, S, Raychaudhuri, S, Ferreira, T, Wood, AR, Weyant, RJ, Segre, AV, Speliotes, EK, Wheeler, E, Soranzo, N, Park, J-H, Yang, J, Gudbjartsson, D, Heard-Costa, NL, Randall, JC, Qi, L, Smith, AV, Maegi, R, Pastinen, T, Liang, L, Heid, IM, Luan, J, Thorleifsson, G, Winkler, TW, Goddard, ME, Lo, KS, Palmer, C, Workalemahu, T, Aulchenko, YS, Johansson, A, Zillikens, MC, Feitosa, MF, Esko, T, Johnson, T, Ketkar, S, Kraft, P, Mangino, M, Prokopenko, I, Absher, D, Albrecht, E, Ernst, F, Glazer, NL, Hayward, C, Hottenga, J-J, Jacobs, KB, Knowles, JW, Kutalik, Z, Monda, KL, Polasek, O, Preuss, M, Rayner, NW, Robertson, NR, Steinthorsdottir, V, Tyrer, JP, Voight, BF, Wiklund, F, Xu, J, Zhao, JH, Nyholt, DR, Pellikka, N, Perola, M, Perry, JRB, Surakka, I, Tammesoo, M-L, Altmaier, EL, Amin, N, Aspelund, T, Bhangale, T, Boucher, G, Chasman, DI, Chen, C, Coin, L, Cooper, MN, Dixon, AL, Gibson, Q, Grundberg, E, Hao, K, Junttila, MJ, Kaplan, LM, Kettunen, J, Koenig, IR, Kwan, T, Lawrence, RW, Levinson, DF, Lorentzon, M, McKnight, B, Morris, AP, Mueller, M, Ngwa, JS, Purcell, S, Rafelt, S, Salem, RM, Salvi, E, Sanna, S, Shi, J, Sovio, U, Thompson, JR, Turchin, MC, Vandenput, L, Verlaan, DJ, Vitart, V, White, CC, Ziegler, A, Almgren, P, Balmforth, AJ, Campbell, H, Citterio, L, De Grandi, A, Dominiczak, A, Duan, J, Elliott, P, Elosua, R, Eriksson, JG, Freimer, NB, Geus, EJC, Glorioso, N, Haiqing, S, Hartikainen, A-L, Havulinna, AS, Hicks, AA, Hui, J, Igl, W, Illig, T, Jula, A, Kajantie, E, Kilpelaeinen, TO, Koiranen, M, Kolcic, I, Koskinen, S, Kovacs, P, Laitinen, J, Liu, J, Lokki, M-L, Marusic, A, Maschio, A, Meitinger, T, Mulas, A, Pare, G, Parker, AN, Peden, JF, Petersmann, A, Pichler, I, Pietilainen, KH, Pouta, A, Riddertrale, M, Rotter, JI, Sambrook, JG, Sanders, AR, Schmidt, CO, Sinisalo, J, Smit, JH, Stringham, HM, Walters, GB, Widen, E, Wild, SH, Willemsen, G, Zagato, L, Zgaga, L, Zitting, P, Alavere, H, Farrall, M, McArdle, WL, Nelis, M, Peters, MJ, Ripatti, S, vVan Meurs, JBJ, Aben, KK, Ardlie, KG, Beckmann, JS, Beilby, JP, Bergman, RN, Bergmann, S, Collins, FS, Cusi, D, den Heijer, M, Eiriksdottir, G, Gejman, PV, Hall, AS, Hamsten, A, Huikuri, HV, Iribarren, C, Kahonen, M, Kaprio, J, Kathiresan, S, Kiemeney, L, Kocher, T, Launer, LJ, Lehtimaki, T, Melander, O, Mosley, TH, Musk, AW, Nieminen, MS, O'Donnell, CJ, Ohlsson, C, Oostra, B, Palmer, LJ, Raitakari, O, Ridker, PM, Rioux, JD, Rissanen, A, Rivolta, C, Schunkert, H, Shuldiner, AR, Siscovick, DS, Stumvoll, M, Toenjes, A, Tuomilehto, J, van Ommen, G-J, Viikari, J, Heath, AC, Martin, NG, Montgomery, GW, Province, MA, Kayser, M, Arnold, AM, Atwood, LD, Boerwinkle, E, Chanock, SJ, Deloukas, P, Gieger, C, Gronberg, H, Hall, P, Hattersley, AT, Hengstenberg, C, Hoffman, W, Lathrop, GM, Salomaa, V, Schreiber, S, Uda, M, Waterworth, D, Wright, AF, Assimes, TL, Barroso, I, Hofman, A, Mohlke, KL, Boomsma, DI, Caulfield, MJ, Cupples, LA, Erdmann, J, Fox, CS, Gudnason, V, Gyllensten, U, Harris, TB, Hayes, RB, Jarvelin, M-R, Mooser, V, Munroe, PB, Ouwehand, WH, Penninx, BW, Pramstaller, PP, Quertermous, T, Rudan, I, Samani, NJ, Spector, TD, Voelzke, H, Watkins, H, Wilson, JF, Groop, LC, Haritunians, T, Hu, FB, Kaplan, RC, Metspalu, A, North, KE, Schlessinger, D, Wareham, NJ, Hunter, DJ, O'Connell, JR, Strachan, DP, Schadt, H-E, Thorsteinsdottir, U, Peltonen, L, Uitterlinden, AG, Visscher, PM, Chatterjee, N, Loos, RJF, Boehnke, M, McCarthy, MI, Ingelsson, E, Lindgren, CM, Abecasis, GR, Stefansson, K, Frayling, TM, and Hirschhorn, JN
- Abstract
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can ide
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- 2010
222. Microbial DNA fingerprinting of human fingerprints: dynamic colonization of fingertip microflora challenges human host inferences for forensic purposes
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Tims, S., van Wamel, W., Endtz, H.P., van Belkum, A., Kayser, M., Tims, S., van Wamel, W., Endtz, H.P., van Belkum, A., and Kayser, M.
- Abstract
Human fingertip microflora is transferred to touched objects and may provide forensically relevant information on individual hosts, such as on geographic origins, if endogenous microbial skin species/strains would be retrievable from physical fingerprints and would carry geographically restricted DNA diversity. We tested the suitability of physical fingerprints for revealing human host information, with geographic inference as example, via microbial DNA fingerprinting. We showed that the transient exogenous fingertip microflora is frequently different from the resident endogenous bacteria of the same individuals. In only 54% of the experiments, the DNA analysis of the transient fingertip microflora allowed the detection of defined, but often not the major, elements of the resident microflora. Although we found microbial persistency in certain individuals, time-wise variation of transient and resident microflora within individuals was also observed when resampling fingerprints after 3 weeks. While microbial species differed considerably in their frequency spectrum between fingerprint samples from volunteers in Europe and southern Asia, there was no clear geographic distinction between Staphylococcus strains in a cluster analysis, although bacterial genotypes did not overlap between both continental regions. Our results, though limited in quantity, clearly demonstrate that the dynamic fingerprint microflora challenges human host inferences for forensic purposes including geographic ones. Overall, our results suggest that human fingerprint microflora is too dynamic to allow for forensic marker developments for retrieving human information
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- 2010
223. Polymer-Supported Synthesis of Oligosaccharides Using a Diisopropylsiloxane Linker and Trichloroacetimidate Donors
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Kayser, M. Mar, Paz, José L. de, Nieto, Pedro M., Kayser, M. Mar, Paz, José L. de, and Nieto, Pedro M.
- Abstract
We describe herein the polymer-supported synthesis of biologically relevant oligosaccharides using a diisopropylsiloxane linker and trichloroacetimidates as glycosyl donors. Siloxane linkers offer important advantages over closely related silyl ethers since even sterically hindered alcohols can be directly loaded onto commercially available polymers, such as soluble polyethylene glycol (PEG), without prior manipulation of the support. Final products can be easily detached by mild fluoridolysis to afford OH-tagged sugar probes. We followed an acceptor-bound approach that fixed the nucleophile on the polymer, and we selected soluble PEG as the support due to higher reactivity of bound sugars and easy reaction monitoring. Following this strategy, the trisaccharide repeating unit of the capsular polysaccharide of Neisseriameningitidis (serogroup L) and the disaccharide containing the structural motif of hyaluronic acid were successfully synthesized.
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- 2010
224. Exploration of the use of an acylsulfonamide safety-catch linker for the polymer-supported synthesis of hyaluronic acid oligosaccharides
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Paz, José L. de, Kayser, M. Mar, Macchione, Giuseppe, Nieto, Pedro M., Paz, José L. de, Kayser, M. Mar, Macchione, Giuseppe, and Nieto, Pedro M.
- Abstract
The synthesis of hyaluronic acid oligosaccharides on polyethylene glycol (PEG) using an acylsulfonamide linker has been explored. Hyaluronic acid is a challenging synthetic target that usually involves the condensation of highly disarmed glucuronic acid building blocks. Amine-ended PEG monomethyl ether was efficiently functionalized with a hydroxyl-terminated acylsulfonamide linker. Suitably protected d-glucosamine (GlcN) and d-glucuronic acid (GlcA) monosaccharide building blocks were coupled to the polymer acceptor using the trichloroacetimidate glycosylation method. The sulfonamide safety-catch linker enables simultaneous cleavage of the monosaccharide from the polymer and orthogonal functionalization for further (bio)-conjugation of the sugar sample. Subsequent glycosylation of PEG-bound glycosyl acceptor to generate hyaluronic acid oligosaccharide chain failed. Model glycosylation experiments in solution and on soluble support using the same unreactive acceptors and donors allows for the synthesis of an orthogonally protected hyaluronic acid disaccharide and suggest that the encountered difficulties could be attributed to the presence of the N-acylsulfonamide.
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- 2010
225. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
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Estrada, K., Krawczak, M., Schreiber, S, van Duijn, K., Stolk, L., van Meurs, J.B.J., Liu, F., Penninx, B.W.J.H., Smit, J.H., Vogelzangs, N., Hottenga, J.J., Willemsen, G., de Geus, E.J.C., Lorentzon, M., von Eller-Eberstein, H., Lips, P.T.A.M., van Schoor, N.M., Pop, V., de Keijzer, J., Hofman, A., Aulchenko, Y.S., Oostra, B.A., Ohlsson, C., Boomsma, D.I., Uitterlinden, A.G., van Duijn, C.M., Rivadeneira, F.F., Kayser, M., Estrada, K., Krawczak, M., Schreiber, S, van Duijn, K., Stolk, L., van Meurs, J.B.J., Liu, F., Penninx, B.W.J.H., Smit, J.H., Vogelzangs, N., Hottenga, J.J., Willemsen, G., de Geus, E.J.C., Lorentzon, M., von Eller-Eberstein, H., Lips, P.T.A.M., van Schoor, N.M., Pop, V., de Keijzer, J., Hofman, A., Aulchenko, Y.S., Oostra, B.A., Ohlsson, C., Boomsma, D.I., Uitterlinden, A.G., van Duijn, C.M., Rivadeneira, F.F., and Kayser, M.
- Abstract
Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (P
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- 2009
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226. Three genome-wide association studies ans a linkage analysis identify HERC2 as a human iris color gene.
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Kayser, M., Liu, F., Janssens, A.C., Rivadeneira, F., Lao, O., van Duijn, K., Vermeulen, M., Arp, P., Jhamai, M.M., VanIJken, W.F., Den Dunnen, J.T., Heath, S., Zelenika, D., Despriet, D.D., Klaver, C.C., Vingerling, J.R., de Jong, P.T.V.M., Hofman, A., Aulchenko, Y.S., Uitterlinden, A.G., Oostra, B.A., van Duijn, C.M., Kayser, M., Liu, F., Janssens, A.C., Rivadeneira, F., Lao, O., van Duijn, K., Vermeulen, M., Arp, P., Jhamai, M.M., VanIJken, W.F., Den Dunnen, J.T., Heath, S., Zelenika, D., Despriet, D.D., Klaver, C.C., Vingerling, J.R., de Jong, P.T.V.M., Hofman, A., Aulchenko, Y.S., Uitterlinden, A.G., Oostra, B.A., and van Duijn, C.M.
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- 2008
227. Correlation between Genetic and Geographic Structure in Europe
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Lao, O., Lu, T.T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L.A., Comas, D., Holmlund, Gunilla, Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U., Werge, T., Rivadeneira, F., Hofman, A., Uitterlinden, A.G., Gieger, C., Wichmann, H.-E., Ruther, A., Schreiber, S., Becker, C., Nurnberg, P., Nelson, M.R., Krawczak, M., Kayser, M., Lao, O., Lu, T.T., Nothnagel, M., Junge, O., Freitag-Wolf, S., Caliebe, A., Balascakova, M., Bertranpetit, J., Bindoff, L.A., Comas, D., Holmlund, Gunilla, Kouvatsi, A., Macek, M., Mollet, I., Parson, W., Palo, J., Ploski, R., Sajantila, A., Tagliabracci, A., Gether, U., Werge, T., Rivadeneira, F., Hofman, A., Uitterlinden, A.G., Gieger, C., Wichmann, H.-E., Ruther, A., Schreiber, S., Becker, C., Nurnberg, P., Nelson, M.R., Krawczak, M., and Kayser, M.
- Abstract
Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry. © 2008 Elsevier Ltd. All rights reserved.
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- 2008
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228. Kein Fall wie er im Buche steht! Das Good-Syndrom - ein Fallbericht
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Nestler, O., additional, Krönert, C., additional, Eichhorst, B., additional, Kayser, M., additional, Wollina, U., additional, and Unger, L., additional
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- 2013
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229. Reproductive endocrinology
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Nazzaro, A., primary, Salerno, A., additional, Di Iorio, L., additional, Landino, G., additional, Marino, S., additional, Pastore, E., additional, Fabregues, F., additional, Iraola, A., additional, Casals, G., additional, Creus, M., additional, Peralta, S., additional, Penarrubia, J., additional, Manau, D., additional, Civico, S., additional, Balasch, J., additional, Lindgren, I., additional, Giwercman, Y. L., additional, Celik, E., additional, Turkcuoglu, I., additional, Ata, B., additional, Karaer, A., additional, Kirici, P., additional, Berker, B., additional, Park, J., additional, Kim, J., additional, Rhee, J., additional, Krishnan, M., additional, Rustamov, O., additional, Russel, R., additional, Fitzgerald, C., additional, Roberts, S., additional, Hapuarachi, S., additional, Tan, B. K., additional, Mathur, R. S., additional, van de Vijver, A., additional, Blockeel, C., additional, Camus, M., additional, Polyzos, N., additional, Van Landuyt, L., additional, Tournaye, H., additional, Turhan, N. O., additional, Hizli, D., additional, Kamalak, Z., additional, Kosus, A., additional, Kosus, N., additional, Kafali, H., additional, Lukaszuk, A., additional, Kunicki, M., additional, Liss, J., additional, Bednarowska, A., additional, Jakiel, G., additional, Lukaszuk, K., additional, Lukaszuk, M., additional, Olszak-Sokolowska, B., additional, Wasniewski, T., additional, Neuberg, M., additional, Cavalcanti, V., additional, Peluso, C., additional, Lechado, B. L., additional, Cordts, E. B., additional, Christofolini, D. M., additional, Barbosa, C. P., additional, Bianco, B., additional, Venetis, C. A., additional, Kolibianakis, E. M., additional, Bosdou, J., additional, Tarlatzis, B. C., additional, Onal, M., additional, Gungor, D. N., additional, Acet, M., additional, Kahraman, S., additional, Kuijper, E., additional, Twisk, J., additional, Caanen, M., additional, Korsen, T., additional, Hompes, P., additional, Kushnir, M., additional, Rockwood, A., additional, Meikle, W., additional, Lambalk, C. B., additional, Yan, X., additional, Dai, X., additional, Wang, J., additional, Zhao, N., additional, Cui, Y., additional, Liu, J., additional, Yarde, F., additional, Maas, A. H. E. M., additional, Franx, A., additional, Eijkemans, M. J. C., additional, Drost, J. T., additional, van Rijn, B. B., additional, van Eyck, J., additional, van der Schouw, Y. T., additional, Broekmans, F. J. M., additional, Martyn, F., additional, Anglim, B., additional, Wingfield, M., additional, Fang, T., additional, Yan, G. J., additional, Sun, H. X., additional, Hu, Y. L., additional, Chrudimska, J., additional, Krenkova, P., additional, Macek, M., additional, Teixeira da Silva, J., additional, Cunha, M., additional, Silva, J., additional, Viana, P., additional, Goncalves, A., additional, Barros, N., additional, Oliveira, C., additional, Sousa, M., additional, Barros, A., additional, Nelson, S. M., additional, Lloyd, S. M., additional, McConnachie, A., additional, Khader, A., additional, Fleming, R., additional, Lawlor, D. A., additional, Thuesen, L., additional, Andersen, A. N., additional, Loft, A., additional, Smitz, J., additional, Abdel-Rahman, M., additional, Ismail, S., additional, Silk, J., additional, Abdellah, M., additional, Abdellah, A. H., additional, Ruiz, F., additional, Cruz, M., additional, Piro, M., additional, Collado, D., additional, Garcia-Velasco, J. A., additional, Requena, A., additional, Kollmann, Z., additional, Bersinger, N. A., additional, McKinnon, B., additional, Schneider, S., additional, Mueller, M. D., additional, von Wolff, M., additional, Vaucher, A., additional, Weiss, B., additional, Stute, P., additional, Marti, U., additional, Chai, J., additional, Yeung, W. Y. T., additional, Lee, C. Y. V., additional, Li, W. H. R., additional, Ho, P. C., additional, Ng, H. Y. E., additional, Kim, S. M., additional, Kim, S. H., additional, Jee, B. C., additional, Ku, S., additional, Suh, C. S., additional, Choi, Y. M., additional, Kim, J. G., additional, Moon, S. Y., additional, Lee, J. H., additional, Kim, S. G., additional, Kim, Y. Y., additional, Kim, H. J., additional, Lee, K. H., additional, Park, I. H., additional, Sun, H. G., additional, Hwang, Y. I., additional, Sung, N. Y., additional, Choi, M. H., additional, Cha, S. H., additional, Park, C. W., additional, Kim, J. Y., additional, Yang, K. M., additional, Song, I. O., additional, Koong, M. K., additional, Kang, I. S., additional, Kim, H. O., additional, Haines, C., additional, Wong, W. Y., additional, Kong, W. 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D., additional, Ratnasabapathy, R., additional, Izzi-Engbeaya, C., additional, Lim, A., additional, Patel, D. A., additional, Ghatei, M. A., additional, Bloom, S. R., additional, Dhillo, W. S., additional, Colodron, M., additional, Guillen, J. J., additional, Garcia, D., additional, Coll, O., additional, Vassena, R., additional, Vernaeve, V., additional, Pazoki, H., additional, Bolouri, G., additional, Farokhi, F., additional, Azarbayjani, M. A., additional, Alebic, M. S., additional, Stojanovic, N., additional, Abali, R., additional, Yuksel, A., additional, Aktas, C., additional, Celik, C., additional, Guzel, S., additional, Erfan, G., additional, Sahin, O., additional, Zhongying, H., additional, Shangwei, L., additional, Qianhong, M., additional, Wei, F., additional, Lei, L., additional, Zhun, X., additional, Yan, W., additional, De Baerdemaeker, A., additional, Tilleman, K., additional, Vansteelandt, S., additional, Oliveira, J. B. A., additional, Baruffi, R. L. R., additional, Petersen, C. G., additional, Mauri, A. L., additional, Nascimento, A. M., additional, Vagnini, L., additional, Ricci, J., additional, Cavagna, M., additional, Massaro, F. C., additional, Pontes, A., additional, Franco, J. G., additional, El-khayat, W., additional, Elsadek, M., additional, Foroozanfard, F., additional, Saberi, H., additional, Moravvegi, A., additional, Kazemi, M., additional, Gidoni, Y. S., additional, Raziel, A., additional, Friedler, S., additional, Strassburger, D., additional, Hadari, D., additional, Kasterstein, E., additional, Ben-Ami, I., additional, Komarovsky, D., additional, Maslansky, B., additional, Bern, O., additional, Ron-El, R., additional, Izquierdo, M. P., additional, Araico, F., additional, Somova, O., additional, Feskov, O., additional, Feskova, I., additional, Bezpechnaya, I., additional, Zhylkova, I., additional, Tishchenko, O., additional, Oguic, S. K., additional, Baldani, D. P., additional, Skrgatic, L., additional, Simunic, V., additional, Vrcic, H., additional, Rogic, D., additional, Juras, J., additional, Goldstein, M. S., additional, Garcia De Miguel, L., additional, Campo, M. C., additional, Gurria, A., additional, Alonso, J., additional, Serrano, A., additional, Marban, E., additional, Shalev, L., additional, Yung, Y., additional, Yerushalmi, G., additional, Giovanni, C., additional, Has, J., additional, Maman, E., additional, Monterde, M., additional, Marzal, A., additional, Vega, O., additional, Rubio, J. m., additional, Diaz-Garcia, C., additional, Eapen, A., additional, Datta, A., additional, Kurinchi-selvan, A., additional, Birch, H., additional, Lockwood, G. M., additional, Ornek, M. C., additional, Ates, U., additional, Usta, T., additional, Goksedef, C. P., additional, Bruszczynska, A., additional, Glowacka, J., additional, Jaguszewska, K., additional, Oehninger, S., additional, Nelson, S., additional, Verweij, P., additional, Stegmann, B., additional, Ando, H., additional, Takayanagi, T., additional, Minamoto, H., additional, Suzuki, N., additional, Rubinshtein, N., additional, Saltek, S., additional, Demir, B., additional, Dilbaz, B., additional, Demirtas, C., additional, Kutteh, W., additional, Shapiro, B., additional, Witjes, H., additional, Gordon, K., additional, Lauritsen, M. P., additional, Pinborg, A., additional, Freiesleben, N. L., additional, Mikkelsen, A. L., additional, Bjerge, M. R., additional, Chakraborty, P., additional, Goswami, S. K., additional, Chakravarty, B. N., additional, Mittal, M., additional, Bajoria, R., additional, Narvekar, N., additional, Chatterjee, R., additional, Bentzen, J. G., additional, Johannsen, T. H., additional, Scheike, T., additional, Friis-Hansen, L., additional, Sunkara, S., additional, Coomarasamy, A., additional, Faris, R., additional, Braude, P., additional, Khalaf, Y., additional, Makedos, A., additional, Masouridou, S., additional, Chatzimeletiou, K., additional, Zepiridis, L., additional, Mitsoli, A., additional, Lainas, G., additional, Sfontouris, I., additional, Tzamtzoglou, A., additional, Kyrou, D., additional, Lainas, T., additional, Fermin, A., additional, Crisol, L., additional, Exposito, A., additional, Prieto, B., additional, Mendoza, R., additional, Matorras, R., additional, Louwers, Y., additional, Lao, O., additional, Kayser, M., additional, Palumbo, A., additional, Sanabria, V., additional, Rouleau, J. P., additional, Puopolo, M., additional, Hernandez, M. J., additional, Rubio, J. M., additional, Ozturk, S., additional, Sozen, B., additional, Yaba-Ucar, A., additional, Mutlu, D., additional, Demir, N., additional, Olsson, H., additional, Sandstrom, R., additional, Grundemar, L., additional, Papaleo, E., additional, Corti, L., additional, Rabellotti, E., additional, Vanni, V. S., additional, Potenza, M., additional, Molgora, M., additional, Vigano, P., additional, Candiani, M., additional, Fernandez-Sanchez, M., additional, Bosch, E., additional, Visnova, H., additional, Barri, P., additional, Fauser, B. J. C. M., additional, Arce, J. C., additional, Peluso, P., additional, Trevisan, C. M., additional, Fonseca, F. A., additional, Bakas, P., additional, Vlahos, N., additional, Hassiakos, D., additional, Tzanakaki, D., additional, Gregoriou, O., additional, Liapis, A., additional, Creatsas, G., additional, Adda-Herzog, E., additional, Steffann, J., additional, Sebag-Peyrelevade, S., additional, Poulain, M., additional, Benachi, A., additional, Fanchin, R., additional, Zhang, D., additional, Aybar, F., additional, Temel, S., additional, Hamdine, O., additional, Macklon, N. S., additional, Laven, J. S., additional, Cohlen, B. J., additional, Verhoeff, A., additional, van Dop, P. A., additional, Bernardus, R. E., additional, Oosterhuis, G. J. E., additional, Holleboom, C. A. G., additional, van den Dool-Maasland, G. C., additional, Verburg, H. J., additional, van der Heijden, P. F. M., additional, Blankhart, A., additional, Fauser, B. C. J. M., additional, Broekmans, F. J., additional, Bhattacharya, J., additional, Mitra, A., additional, Dutta, G. B., additional, Kundu, A., additional, Bhattacharya, M., additional, Kundu, S., additional, Pigny, P., additional, Dassonneville, A., additional, Catteau-Jonard, S., additional, Decanter, C., additional, Dewailly, D., additional, Pouly, J., additional, Olivennes, F., additional, Massin, N., additional, Celle, M., additional, Caizergues, N., additional, Gaudoin, M., additional, Messow, M., additional, Vanhove, L., additional, Peigne, M., additional, Thomas, P., additional, and Robin, G., additional
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- 2013
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230. Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization
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Maza, Susana, primary, Mar Kayser, M., additional, Macchione, Giuseppe, additional, López-Prados, Javier, additional, Angulo, Jesús, additional, de Paz, José L., additional, and Nieto, Pedro M., additional
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- 2013
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231. A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.
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Liu, F., Arias Vasquez, A., Sleegers, K., Aulchenko, Y.S., Kayser, M., Sanchez-Juan, P., Feng, B.J., Bertoli-Avella, A.M., Swieten, J. van, Axenovich, T.I., Heutink, P., Broeckhoven, C. van, Oostra, B.A., Duijn, C.M. van, Liu, F., Arias Vasquez, A., Sleegers, K., Aulchenko, Y.S., Kayser, M., Sanchez-Juan, P., Feng, B.J., Bertoli-Avella, A.M., Swieten, J. van, Axenovich, T.I., Heutink, P., Broeckhoven, C. van, Oostra, B.A., and Duijn, C.M. van
- Abstract
Contains fulltext : 52087.pdf (publisher's version ) (Closed access), Alzheimer disease (AD) is the most common cause of dementia. We conducted a genome screen of 103 patients with late-onset AD who were ascertained as part of the Genetic Research in Isolated Populations (GRIP) program that is conducted in a recently isolated population from the southwestern area of The Netherlands. All patients and their 170 closely related relatives were genotyped using 402 microsatellite markers. Extensive genealogy information was collected, which resulted in an extremely large and complex pedigree of 4,645 members. The pedigree was split into 35 subpedigrees, to reduce the computational burden of linkage analysis. Simulations aiming to evaluate the effect of pedigree splitting on false-positive probabilities showed that a LOD score of 3.64 corresponds to 5% genomewide type I error. Multipoint analysis revealed four significant and one suggestive linkage peaks. The strongest evidence of linkage was found for chromosome 1q21 (heterogeneity LOD [HLOD]=5.20 at marker D1S498). Approximately 30 cM upstream of this locus, we found another peak at 1q25 (HLOD=4.0 at marker D1S218). These two loci are in a previously established linkage region. We also confirmed the AD locus at 10q22-24 (HLOD=4.15 at marker D10S185). There was significant evidence of linkage of AD to chromosome 3q22-24 (HLOD=4.44 at marker D3S1569). For chromosome 11q24-25, there was suggestive evidence of linkage (HLOD=3.29 at marker D11S1320). We next tested for association between cognitive function and 4,173 single-nucleotide polymorphisms in the linked regions in an independent sample consisting of 197 individuals from the GRIP region. After adjusting for multiple testing, we were able to detect significant associations for cognitive function in four of five AD-linked regions, including the new region on chromosome 3q22-24 and regions 1q25, 10q22-24, and 11q25. With use of cognitive function as an endophenotype of AD, our study indicates the that the RGSL2, RALGPS2, and C1orf49 genes
- Published
- 2007
232. The attitude of grassland farmers towards nature conservation and agri-environment measures—A survey-based analysis.
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Hammes, V., Eggers, M., Isselstein, J., and Kayser, M.
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FARMERS' attitudes ,NATURE conservation ,AGRICULTURE & the environment ,AGRICULTURAL productivity ,AGRICULTURAL policy - Abstract
Grasslands have a multi-layer protection function for nature, biodiversity and climate. These functions can be fostered by an adapted management on grassland farms. Promoting nature protection alongside agricultural production is an aim of European agricultural policy. However, a number of studies indicate that existing Agri-environment measures (AEM) are not as effective as assumed, mainly because they are not sufficiently used by farmers. We investigated the view of grassland farmers on nature conservation and on existing AEM in four distinct regions on a west to east gradient in the North German Plain. We conducted a survey on 82 grassland farms inquiring basic farm data and asking questions on general agricultural issues and nature protection. The results indicate that the majority of all respondents is generally interested in nature conservation and believes it to be of concern for every farmer. In contrast, only a minority of grassland farmers is using the existing AEM to the full extend on their own farm. By applying the concept of farming styles, we classified farmers into four groups, namely Traditionalist, Idealist, Modernist, and Yield Optimizer. These farming styles groups differ in farm and management parameters, general attitudes towards agricultural issues, farming objectives and economic success. We found that in our survey the farming styles groups differ in their attitude towards nature conservation. However, they do not differ in the adoption of AEM and have different reasons for not taking part. We state that for a better implementation of AEM into agricultural practice a better communication, which is adapted to the different ways that farmers manage their farm and think and feel, is needed. Consequently, AEM need to be revised as well. [ABSTRACT FROM AUTHOR]
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- 2016
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233. DNA Commission of the International Society for Forensic Genetics (ISFG): an update of the recommendations on the use of Y-STRs in forensic analysis
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Gusmão, L, Butler, J M, Carracedo, A, Gill, P, Kayser, M, Mayr, W R, Morling, N, Prinz, M, Roewer, L, Tyler-Smith, C, Schneider, P M, Gusmão, L, Butler, J M, Carracedo, A, Gill, P, Kayser, M, Mayr, W R, Morling, N, Prinz, M, Roewer, L, Tyler-Smith, C, and Schneider, P M
- Abstract
Udgivelsesdato: 2006-Jul, The DNA Commission of the International Society of Forensic Genetics (ISFG) regularly publishes guidelines and recommendations concerning the application of DNA polymorphisms to the problems of human identification. A previous recommendation published in 2001 has already addressed Y-chromosome polymorphisms, with particular emphasis on short tandem repeats (STRs). Since then, the use of Y-STRs has become very popular, and numerous new loci have been introduced. The current recommendations address important aspects to clarify problems regarding the nomenclature, the definition of loci and alleles, population genetics and reporting methods
- Published
- 2006
234. Successful treatment of severe rheumatoid vasculitis by infliximab
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Unger, L, Kayser, M, and Nusslein, HG
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Infliximab -- Evaluation -- Complications and side effects ,Vasculitis -- Causes of -- Care and treatment -- Complications and side effects ,Rheumatoid arthritis -- Care and treatment -- Complications and side effects ,Health - Abstract
Rheumatoid vasculitis (RV) is a severe complication of rheumatoid arthritis (RA), which like a primary necrotising vasculitis can affect any organ but characteristically presents with painful cutaneous ulcers and systemic [...]
- Published
- 2003
235. Potassium leaching following silage maize on a productive sandy soil
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Kayser, M., primary, Benke, M., additional, and Isselstein, J., additional
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- 2012
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236. A Morphological Assessment of Bovine Chondrocytes Cultured on Poly(Ethyl Methacrylate)/Tetrahydrofurfuryl Methacrylate
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Sawtell, R. M., Kayser, M. V., and Downes, S.
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tetrahydrofurfuryl methacrylate ,Cartilage repair ,poly( ethyl methacrylate) ,hydroxyethyl methacrylate ,chondrocytes ,biomaterial ,in vitro ,tissue culture ,scanning electron microscopy ,Biomedical Engineering and Bioengineering - Abstract
A heterocyclic methacrylate polymer system, PEMA/THFMA, has shown potential as a biomaterial for cartilage repair in a rabbit model and has properties making it suitable for use clinically. The ability of the polymer system, PEMA/THFMA, and a related system, PEMA/HEMA, to support chondrocytes in vitro was assessed by scanning electron microscopy. Chondrocytes adhered to the surface of the PEMA/THFMA by day one, having a rounded morphology and clustered appearance opposed to the Thermanox® control, where the cells had spread out and become fibroblastic in appearance. The chondrocytes divided rapidly on the PEMA/ THFMA system by day three and had completely covered the surface by day seven. In contrast, chondrocytes did not adhere well to the more hydrophilic PEMA/ HEMA system. A few cells were seen on the surface by day one and by days three and seven, there was no evidence of cell growth or spreading across the surface. In conclusion, the PEMA/THFMA system can support chondrocytes in vitro, whereas the PEMA/HEMA system does not.
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- 1995
237. Phytodiversity of temperate permanent grasslands: ecosystem services for agriculture and livestock management for diversity conservation
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Wrage, N., primary, Strodthoff, J., additional, Cuchillo, H. M., additional, Isselstein, J., additional, and Kayser, M., additional
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- 2011
- Full Text
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238. Bridging Near and Remote Oceania: mtDNA and NRY Variation in the Solomon Islands
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Delfin, F., primary, Myles, S., additional, Choi, Y., additional, Hughes, D., additional, Illek, R., additional, van Oven, M., additional, Pakendorf, B., additional, Kayser, M., additional, and Stoneking, M., additional
- Published
- 2011
- Full Text
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239. Genetic Ancestry Affects the Phenotype of Normogonadotropic Anovulatory (WHOII) Subfertility
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Valkenburg, O., primary, Lao, O., additional, Schipper, I., additional, Louwers, Y., additional, Uitterlinden, A. G., additional, Kayser, M., additional, and Laven, J. S. E., additional
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- 2011
- Full Text
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240. EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner
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Nolt, M. J., primary, Lin, Y., additional, Hruska, M., additional, Murphy, J., additional, Sheffler-Colins, S. I., additional, Kayser, M. S., additional, Passer, J., additional, Bennett, M. V. L., additional, Zukin, R. S., additional, and Dalva, M. B., additional
- Published
- 2011
- Full Text
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241. Krankheiten des Sternoklavikulargelenkes
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Enderlein, M., primary, Kayser, M., additional, and Unger, L., additional
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- 2011
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242. The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease
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Kayser, M. S., primary and Dalmau, J., additional
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- 2011
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243. Unexpected Island Effects at an Extreme: Reduced Y Chromosome and Mitochondrial DNA Diversity in Nias
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van Oven, M., primary, Hammerle, J. M., additional, van Schoor, M., additional, Kushnick, G., additional, Pennekamp, P., additional, Zega, I., additional, Lao, O., additional, Brown, L., additional, Kennerknecht, I., additional, and Kayser, M., additional
- Published
- 2010
- Full Text
- View/download PDF
244. Estimating human age from T-cell DNA rearrangements
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Zubakov, D., primary, Liu, F., additional, van Zelm, M.C., additional, Vermeulen, J., additional, Oostra, B.A., additional, van Duijn, C.M., additional, Driessen, G.J., additional, van Dongen, J.J.M., additional, Kayser, M., additional, and Langerak, A.W., additional
- Published
- 2010
- Full Text
- View/download PDF
245. Population Genetic Structure in Indian Austroasiatic Speakers: The Role of Landscape Barriers and Sex-Specific Admixture
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Chaubey, G., primary, Metspalu, M., additional, Choi, Y., additional, Magi, R., additional, Romero, I. G., additional, Soares, P., additional, van Oven, M., additional, Behar, D. M., additional, Rootsi, S., additional, Hudjashov, G., additional, Mallick, C. B., additional, Karmin, M., additional, Nelis, M., additional, Parik, J., additional, Reddy, A. G., additional, Metspalu, E., additional, van Driem, G., additional, Xue, Y., additional, Tyler-Smith, C., additional, Thangaraj, K., additional, Singh, L., additional, Remm, M., additional, Richards, M. B., additional, Lahr, M. M., additional, Kayser, M., additional, Villems, R., additional, and Kivisild, T., additional
- Published
- 2010
- Full Text
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246. ChemInform Abstract: Structure and Reactivity of a Stabilized Phosphorane: Methyl( triphenylphosphoranylidene)acetate.
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KAYSER, M. H., primary and HOOPER, D. L., additional
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- 2010
- Full Text
- View/download PDF
247. ChemInform Abstract: Application of Yeast-Catalyzed Reductions to the Synthesis of (2R,3S)- Phenylisoserine.
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KEARNS, J., primary and KAYSER, M. M., additional
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- 2010
- Full Text
- View/download PDF
248. ChemInform Abstract: Synthesis of Enol Lactones Under a Solid/Liquid Phase-Transfer Wittig Reaction.
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ZHU, J., primary and KAYSER, M. M., additional
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- 2010
- Full Text
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249. ChemInform Abstract: Unsaturated Lactones: Synthesis and Applications.
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YU, H., primary and KAYSER, M. M., additional
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- 2010
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250. ChemInform Abstract: A “Designer Yeast” That Catalyzes the Kinetic Resolutions of 2-Alkyl- Substituted Cyclohexanones by Enantioselective Baeyer-Villiger Oxidations.
- Author
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STEWART, J. D., primary, REED, K. W., additional, ZHU, J., additional, CHEN, G., additional, and KAYSER, M. M., additional
- Published
- 2010
- Full Text
- View/download PDF
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