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213. Geocoding of Synthetic Aperture Radar Images Using Digital Vector Maps.

Author

Karjalainen, M.

Abstract

In this letter, a possible approach to automate synthetic aperture radar (SAR) geocoding (or to automatically refine the existing one) is presented. The procedure is based on edge detection, where ground control lines obtained from digital vector maps are located in the SAR images. In geocoding, affine, projective, and rigorous SAR sensor transformation models can be used. According to the experiments, the procedure seems to be accurate and reliable as long as the initial values of the geocoding transformation model are accurate enough. The procedure copes well with displacements of about ten pixels on SAR images, but good results have been obtained in cases of even larger displacements. According to the well-defined checkpoints, the resulting geocoding accuracies for test images were around a few pixels. When the rigorous SAR sensor model was used, the accuracies were less than two pixels in most cases. [ABSTRACT FROM PUBLISHER]

Published
2007
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215. Infantile 4-tert-octylphenol exposure transiently inhibits rat ovarian steroidogenesis and steroidogenic acute regulatory protein (StAR) expression

Author

Myllymäki, S.A., Karjalainen, M., Haavisto, T.E., Toppari, J., and Paranko, J.

Subjects
*PHENOLS, *OVARIES, *PROTEINS, *STEROIDS
Abstract

Abstract: Phenolic compounds, such as 4-tert-octylphenol (OP), have been shown to interfere with rat ovarian steroidogenesis. However, little is known about steroidogenic effects of infantile OP exposure on immature ovary. The aim of the present study was to investigate the effects of infantile OP exposure on plasma FSH, LH, estradiol, and progesterone levels in 14-day-old female rats. The effect on ovarian steroidogenic acute regulatory protein (StAR) and FSH receptor (FSHr) expression was analyzed by Western blotting. Ex vivo analysis was carried out for follicular estradiol, progesterone, testosterone, and cAMP production. Sprague–Dawley rats were given OP (0, 10, 50, or 100 mg/kg) subcutaneously on postnatal days 6, 8, 10, and 12. On postnatal day 14, plasma FSH was decreased and progesterone increased significantly at a dose of 100 mg OP/kg. In addition, the highest OP dose advanced the time of vaginal opening in puberty. OP had no effect on infantile LH and estradiol levels or ovarian FSHr content. Ovarian StAR protein content and ex vivo hormone and cAMP production were decreased at all OP doses compared to controls. However, hormone levels recovered independent on FSH and even increased above the control level during a prolonged culture. On postnatal day 35, no statistically significant differences were seen between control and OP-exposed animals in plasma FSH, LH, estradiol, and progesterone levels, or in ovarian StAR protein content. The results indicate that the effect of OP on the infantile ovary is reversible, while more permanent effects in the hypothalamus and pituitary, as described earlier, are involved in the reduction of circulating FSH levels and premature vaginal opening. [Copyright &y& Elsevier]

Published
2005
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216. Effect of β-sitosterol on precipitation of cholesterol from non-aqueous and aqueous solutions

Author

Christiansen, L., Karjalainen, M., Seppänen-Laakso, T., Hiltunen, R., and Yliruusi, J.

Subjects
*CHOLESTEROL, *PRECIPITATION (Chemistry), *SOLUBILITY
Abstract

The aim of the present work was to study the solubility and phase behaviour of the β-sitosterol–cholesterol mixed crystals in the presence and absence of water. Cholesterol, β-sitosterol and 3:1, 1:1 and 1:3 mixtures of these were co-precipitated from acetone and acetone–water solutions. Precipitated crystals were analysed using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), optical microscopy and Karl–Fischer titrimetry. The quantification of the sterols in solutions was preformed using GC–MS. The solubility of the sterols was mutually limiting. In the aqueous system, the solubility of both the sterols were significantly lower than in the absence of water, but the decrease in the solubility was considerably greater with the more hydrophobic β-sitosterol. In the aqueous system, the total sterol solubility decreased with the increasing proportion of β-sitosterol. The formation of new crystal structures, solid solutions of cholesterol and β-sitosterol, was observed in non-aqueous as well as in aqueous environments except with the lowest cholesterol proportion in the system, in which case mixed crystals with eutectic behaviour were formed. [Copyright &y& Elsevier]

Published
2003
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217. Conservative and operative treatment in cervical burst fractures.

Author

Koivikko, M. P., Myllynen, P., Karjalainen, M., Vornanen, M., and Santavirta, S.

Subjects
CERVICAL cancer, CERVIX uteri diseases, BONE fractures, UTERUS, BONE injuries, CERVIX erosion
Abstract

The aim of this study is to compare the results of non-operative and anterior operative treatment of cervical burst and flexion teardrop fractures. Sixty-nine consecutive patients treated during 1980 to 1995 were reviewed retrospectively. Thirty-four of them had been treated with skull traction or halo-vest and 35 with anterior decompression, bone grafting and fixation by an anterior Caspar plate. Neurological functioning on admission and at the end of the follow-up was assessed by using Frankel’s classification. Kyphosis and spinal canal encroachment by retropulsed fragments were measured radiographically. Operatively treated patients recovered more often with at least one Frankel grade (P = 0.027) and presented less narrowing of the spinal canal (P = 0.0006) and kyphotic deformity (P = 0.00003) at the end of the follow-up. In comparison with the conservative methods, the operative Caspar technique provided superior decompression and fixation as well as promoted the healing of cord injuries caused by burst and flexion teardrop fractures. [ABSTRACT FROM AUTHOR]

Published
2000
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222. Do molecular markers reflect patterns of differentiation in adaptive traits of conifers?

Author

Karhu, A., Hurme, P., Karjalainen, M., Karvonen, P., Kärkkäinen, K., Neale, D., and Savolainen, O.

Abstract

We have examined patterns of variation of several kinds of molecular markers (isozymes, RFLPs of ribosomal DNA and anonymous low-copy number DNA, RAPDs and microsatellites) and an adaptive trait [date of bud set in Scots pine ( Pinus sylvestris L.)]. The study included Finnish Scots pine populations (from latitude 60°N to 70°N) which experience a steep climatic gradient. Common garden experiments show that these populations are adapted to the location of their origin and genetically differentiated in adaptive quantitative traits, e.g. the date of bud set in first-year seedlings. In the northernmost population, bud set took place about 21 days earlier than in the southernmost population. Of the total variation in bud set, 36.4% was found among the populations. All molecular markers showed high levels of within-population variation, while differentiation among populations was low. Among all the studied markers, microsatellites were the most variable (H=0.77). Differences between populations were small, G was less than 0.02. Our study suggests that molecular markers may be poor predictors of the population differentiation of quantitative traits in Scots pine, as exemplified here by bud-set date. [ABSTRACT FROM AUTHOR]

Published
1996
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223. Operative treatment of unstable thoracolumbar fractures by the posterior approach with the use of Williams plates or Harrington rods.

Author

Karjalainen, M., Aho, A., Katevuo, K., and Aho, A J

Abstract

Copyright of International Orthopaedics is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1992
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224. Dimensionally reduced U(1)+Higgs theory in the broken phase.

Author

Karjalainen, M. and Peisa, J.

Abstract

We apply dimensional reduction to the finite temperature U(1)+Higgs theory and study the properties of the reduced 3-dimensional theory in the broken phase using lattice Monte Carlo simulations. We compute analytically the scalar condensate in optimized 2-loop perturbation theory and the correlators in 1-loop perturbation theory. These quantities are also calculated numerically. The two results for the condensate agree well but a 25% difference is observed for the scalar correlator, indicating the need for optimized 2-loop perturbative results. [ABSTRACT FROM AUTHOR]

Published
1997
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225. The Dental Fear Survey Schedule: a study with Finnish children.

Author

ALVESALO, I., MURTOMAA, H., MILGROM, P., HONKANEN, A., KARJALAINEN, M., and TAY, K.-M.

Abstract

Summary. The reliability and validity of the Dental Fear Survey Schedule for Children (DFSS-C) was examined in a sample of 828 school children in Finland. The DFSS-C mean was 22·1. Choking, injections and drilling were the most common fears. Internal consistency indicated a high level of reliability. Factor analysis (principal components, varimax rotation) found three factors accounting for 54% of the scale variance. Factors were defined as (1) fear of highly invasive procedures, such as injections and drilling; (2) fear of potential victimization, including fear of strangers, choking and hospitals; and (3) fear of less invasive procedures, such as opening the mouth and being examined by the dentist. The factor pattern was similar to results obtained with a sample of children in the United States. There were significant differences in fear score for children whose parents reported them fearful and/or reported them to have had a previous bad experience at the dentist. Boys (but not girls) who had a DMFT score of at least 1 had a significantly higher mean DFSS-C score (21·1) than those who were caries free (20·0). These data suggest the DFSS-C operates in Finland as it does in the United States, but that culture-specific minimal scores for determining high dental fear are needed. Résumé. La fiabilité et la validité de l'échelle de mesure de la dentaire chez les enfants (DFSS-C) ont été étudiées chez un échantillon de 828 écoliers de Finlande. Le DFSS-C moyen était de 22,1. Les peurs les plus fréquentes étaient celle de s'étrangler, de la piqûre et de la fraise. Un haut niveau de fiabilité a été trouvé. l'analyse factorielle a montré trois facteurs comptant pour 54% dans l'échelle de variance. Les facteurs étaient définis comme suit: (1) peur des procédures invasives comme les piqûres ou le fraisage; (2) peurs de sévices potentiels incluant la peur des étrangers, de l'étouffement et des hôpitaux; (3) peurs de procédures moins invasives telles que ouvrir la bouche et être examiné par un dentiste. Les résultats étaient similaries à ceux obtenus chez un groupe d'enfants aux Etats-Unis. Il y avait des différences significatives en ce qui concerne la peur pour les enfants dont les parents souffraient eux-même de peur ou avaient eu des expériences difficiles chez le dentiste. Les garçons, mais non les filles, qui avaient un indice CAO d'au moins 1, avaient un indice moyen DFSS-C significativement plus élevé (21,1) que ceux qui étaient sans caries (20,0) Zusammenfassung. Die Zuverlässigkeit und der Wert des 'DFSS-C' (für Angst) wurden als Probe von 828 Schulkindern in Finland untersucht. Der DFSS-C Durchshnitt war 22,1. Ersticken, Spritzen und Bohren waren am meisten gefürchtet. Interne Übereinstimmung besagt ein Hochstand an Zuverlässigkeit. Die Analyse der Faktoren (wichtigste Bestandteile, ...) hat 3 Faktoren die für die 54% Schwankungen der Skala verantwortlich sind, gefunden. Die Faktoren wurden definiert als: (1) Angst vor stark schädigenden Verfahren wie z.B.Spritzen und Bohren, (2) Angst vor erth. Schädigung inkl. Angst vor Fremden, Erstickung und Krankenhäusern, und (3) Angst vor weniger Schädigenden Verfahren wie z.B. Mundöffnen und Untersuchung durch den Zahnarzt. Das Faktoren Muster war den Resultaten der Probe fur Kinder in den USA ähnlich. Es gab bedeutende Unterschiede in bezug auf Angst von Kinder, deren Eltern sie als ängstlich und/oder als solche mit schlechten Erfahrungen beim Zahnarzt beshrieben haben Jungen und nicht Mädchen, die mindestens 1 kariösen-fehlenden-oder gefüllten Zahn hatten, hatten einer bedentend höheren DFSS-C Durchschnitt (21,1) als die kariesfrei waren (20,0). Diese Angaben deuten an, dass die DFSS-C in Finland ähnlich wie in den USA vorgehen, aber dass Kultur spezifische minimale Ergebnisse zur Feststellung der Angst vor Zahnbehandlung gebraucht werden. Resumen. La confiabilidad y validez del Examen el Miedo Dental en Ninos (DFSS-C) fue examinado en una muestra de 828 niños escolares de Finlandia. La media del DFSS-C fue de 22.1. Sofocamiento, inyecciones y preparaciones cavitarias con fresas fueron las situaciones que más miedo causaron. La consistencia interna indicó un alto grado de confiabilidad por parte del examen DFSS-C. El análisis del factor (componentes principales, rotación varimax) encontró tres factors responsables del 54% de la escala de varianza. Los factores fueron definidos como: (1) miedo a procedimiento muy invasivos, tales como inyecciones y preparaciones cavitarias; (2) miedo al potencial de ser víctima, incluyendo miedo a las personas extrañas, sofocamiento y hospitales; y (3) miedo a procedimientos menos invasivos, tal como abrir la boca y ser examinado por un odontólogo. El factor patron fue similar a los resultados obtenidos en una muestra de niños de los Estados Unidos de América. Hubo diferencias significativas en el miedo observado en niños en los cuales los padres reportar on que sus niños tenian miedo y/o reportaron que habían tenido un mala experiencia previa con el odontólogo. Los niños (pero no las niñas) con un valor DMFT de por lo menos 1 tenían un valor medio DFSS-C significativo más alto (21.1) que aquellos libres de caries (20.0). Los datos sugieren que el examen DFSS-C funciona en Finlandia similar que en los Estados Unidos de América, pero se necesitan los valores mínimos específicos a la cultura para determinar el maximo miedo al odontólogo. [ABSTRACT FROM AUTHOR]

Published
1993
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226. Immunocytochemical localization of receptor-bound human chorionic gonadotropin in pseudopregnant rat ovaries.

Author

Kinnunen, R, Karjalainen, M, and Rajaniemi, H

Abstract

Localization of receptor-bound human chorionic gonadotropin (hCG) in pseudopregnant rat ovarian cells was studied by the peroxidase-antiperoxidase (PAP) complex method. The animals were injected, 2,6,12, and 24 hr prior to killing with a single intravenous dose of hCG. The hormone localized to the periphery of the luteal and interstitial glandular cells. The luteal cells seemed to bind different amounts of the hormone, which suggests that the number of receptor varies from one cell to another or that the receptors are not similarly accessible to the circulating hormone in all cells. The hormone seemed to disappear unequally from the luteal cells, possibly due to the variable amounts of primarily bound hormone or to different removal mechanisms. The hormone was distributed unevenly at the luteal cell periphery. This observation supports previous findings that hCG preferentially binds to the cell surface regions directed towards the capillary areas. Compatible results were obtained with anti-hCG serum and with antisera against the hCG subunits. Our results support the previous autoradiographic evidence of the plasma membrane localization of luteinizing hormone receptor in the luteal cells, and are compatible with the concept that only a small fraction of the receptor-hormone complexes may be internalized.

Published
1981
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227. Immunocytochemical localization of receptor human chorionic gonadotropin complexes in rat leydig cells.

Author

Rajaniemi, H, Karjalainen, M, Veijola, M, Ritanen-Kaivamo, S, Kellokumpu, S, and Metsikkö, K

Abstract

Localization of receptor-bound human chorionic gonadotropin (hCG) in rat testis was studied by the peroxidase-antiperoxidase (PAP) complex method. The rats were injected with a single intravenous dose (1000 IU) of hCG. Three, 6, 12, and 24 hr after injection the testes were removed for localization of the hormone. The hormone localized to the periphery of the Leydig cells at all observation points. The intensity of the staining varied between the cells, suggesting that the number of receptors or the accessibility of the receptors to the circulating hormone varies from one cell to another. The staining surrounded the Leydig cells unevenly, but no progressive patching or capping was found. This observation suggests that hCG binds preferentially to the cell surface areas directed toward the capillaries. Compatible results were obtained with anti-hCG serum and with antisera against the hCG subunits. These results are consistent with previous observations that the luteinizing hormone (hCG) receptors accessible to the circulating hormone are located at the surface of the Leydig cells.

Published
1981
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230. Genome‐Wide Association Study of Temporomandibular Disorder‐Related Pain in Finnish Populations.

Author

Leppilahti, J. M., Knuutila, J., Pesonen, P., Vuollo, V., Männikkö, M., Karjalainen, M. K., Suominen, A. L., and Sipilä, K.

Subjects
*PUBLIC health surveillance, *MASTICATORY muscles, *JOINT diseases, *MUSCULOSKELETAL pain, *TEMPOROMANDIBULAR joint, *TEMPOROMANDIBULAR disorders
Abstract

ABSTRACT Background Objective Methods Results Conclusion Temporomandibular disorders (TMD) are multifactorial musculoskeletal pain and dysfunctions in temporomandibular joints (TMJs) and masticatory muscles. Genetic factors play a role in TMD‐related pain, but only a few genome‐wide association studies (GWAS) have been conducted.The aim of this GWAS was to explore genetic factors associated with painful TMD in Finnish populations.Data from two epidemiological surveys, the Northern Finland Birth Cohort 1966 (NFBC1966) and the Health 2000 Survey in Finland, including altogether 468 cases and 6833 controls, were used. Case definition was based on pain on palpation of masticatory muscles and/or TMJs. GWASs of the whole data and stratified by sex were conducted from both cohorts using additive models, followed by meta‐analysis of the two cohorts. Replications of the previously reported TMD risk loci (rs73460075, DMD; rs4794106, SGCA; rs73271865, SP4; rs60249166, RXP2; rs1531554, BAHCCI; rs5862730, OTUD4/SMAD1; rs10092633, SFRP1; rs34612513, SOX14/CLDN18; rs878962, TSPAN9) were also investigated.Four genome‐wide significant loci were found in sex‐stratified analysis of NFBC1966, including associations at three loci in males (rs1023114, PRIM2, p = 5 × 10−9; rs4244867, ALG10, p = 3 × 10−8; rs79841648, ADCYAP1, p = 4 × 10−9) and one locus in females (rs148476652, DNER, p = 4 × 10−9). However, the results could not be replicated in the Health 2000 Survey or in the meta‐analysis of these two cohorts. The previous TMD GWAS associations did not replicate in our data either.Several TMD pain‐associated variants were found in sex‐stratified analysis of NFBC1966, suggesting the role of neuroendocrine stress responses and central nervous system. These findings need to be confirmed in future studies. [ABSTRACT FROM AUTHOR]

Published
2024
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233. Virtual Orchestra Performance

Author

Tapio Takala, Hiipakka, J., Rami Hänninen, Ilmonen, T., Hannu Napari, Tapio Lokki, Savioja, L., Huopaniemi, J., Karjalainen, M., Tero Tolonen, Vesa Valimaki, and Seppo Välimäki

234. Bounds on Lorentz invariance violation from MAGIC observation of GRB 190114C

Author

Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babić, A., Banerjee, B., Barres de Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mender, S., Mićanović, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Perennes, C., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., and Nava, L.

Subjects
higher-order: 0, spectral, quantum gravity: model, Cherenkov counter: imaging, gamma ray: burst, invariance: Lorentz, 7. Clean energy, MAGIC, violation: Lorentz, photon: velocity, energy dependence
Abstract

Physical review letters 125(2), 1-7 (2020). doi:10.1103/PhysRevLett.125.021301, On January 14, 2019, the Major Atmospheric Gamma Imaging Cherenkov telescopes detected GRB 190114C above 0.2 TeV, recording the most energetic photons ever observed from a gamma-ray burst. We use this unique observation to probe an energy dependence of the speed of light in vacuo for photons as predicted by several quantum gravity models. Based on a set of assumptions on the possible intrinsic spectral and temporal evolution, we obtain competitive lower limits on the quadratic leading order of speed of light modification., Published by APS, College Park, Md.

235. Testing two-component models on very-high-energy gamma-ray emitting BL Lac objects

Author

Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babić, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., García López, R. J., Garczarczyk, Markus, Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Coto, R., López-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Mender, S., Mićanović, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tosti, L., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zarić, D., Nievas-Rosillo, M., Arcaro, C., D' Ammando, F., De Palma, F., Hodges, M., Hovatta, T., Kiehlmann, S., Max-Moerbeck, W., Readhead, A. C. S., Reeves, R., Takalo, L., Reinthal, R., Jormanainen, J., Wierda, F., Wagner, S. M., Berdyugin, A., Nabizadeh, A., Talebpour Sheshvan, N., Oksanen, A., Bachev, R., Strigachev, A., and Kehusmaa, P.

Subjects
7. Clean energy
Abstract

Astronomy and astrophysics 640, A132 - (2020). doi:10.1051/0004-6361/202037811, Context. It has become evident that one-zone synchrotron self-Compton models are not always adequate for very-high-energy (VHE) gamma-ray emitting blazars. While two-component models are performing better, they are difficult to constrain due to the large number of free parameters. Aims. In this work, we make a first attempt to take into account the observational constraints from Very Long Baseline Interferometry (VLBI) data, long-term light curves (radio, optical, and X-rays) and optical polarisation to limit the parameter space for a two-component model and test if it can still reproduce the observed spectral energy distribution (SED) of the blazars. Methods. We selected five TeV BL Lac objects based on the availability of VHE gamma-ray and optical polarisation data. We collected constraints for the jet parameters from VLBI observations. We evaluated the contributions of the two components to the optical flux by means of decomposition of long-term radio and optical light curves as well as modeling of the optical polarisation variability of the objects. We selected eight epochs for these five objects, based on the variability observed at VHE gamma rays, for which we constructed the SEDs that we then modeled with a two-component model. Results. We found parameter sets which can reproduce the broadband SED of the sources in the framework of two-component models considering all available observational constraints from VLBI observations. Moreover, the constraints obtained from the long-term behavior of the sources in the lower energy bands could be used to determine the region where the emission in each band originates. Finally, we attempted to use optical polarisation data to shed new light on the behavior of the two components in the optical band. Our observationally constrained two zone model allows explanation of the entire SED from radio to VHE with two co-located emission regions., Published by EDP Sciences, Les Ulis

236. BL Lac object 1ES 0647+250, a decade of MWL observations

Author

Otero-Santos, J., Dorner, D., Morcuende, D., Paneque, D., Fallah Ramazani, V., Prandini, E., Bonnoli, G., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Doro, M., Elsaesser, D., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Paiano, S., Palatiello, M., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.

237. Investigation of the correlation patterns and the Compton dominance variability of Mrk 421 in 2017

Author

Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Babi��, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batkovi��, I., Gonz��lez, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bo��njak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi��eira, E., Prester, D. Dominis, Donini, A., Doro, M., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., L��pez, R. J. Garc��a, Garczarczyk, Markus, Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi��, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H��tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jim��nez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L��pez-Coto, R., L��pez-Moya, M., L��pez-Oramas, A., Loporchio, S., de Oliveira Fraga, B. Machado, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Mart��nez, M., Mazin, D., Menchiari, S., Mender, S., Mi��anovi��, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti��, L., Pe��il, P., Perennes, C., Persic, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Rib��, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., ��nidari��, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri��, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi��, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zari��, D., Baack, D., Balbo, M., Biederbeck, N., Biland, A., Bretz, T., Buss, J., Dorner, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Mannheim, K., Neise, D., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Sliusar, V., Walter, R., D'Ammando, F., Horan, D., Lien, A. Y., Balokovi��, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., L��hteenm��ki, A., Tornikoski, M., Ramakrishnan, V., J��rvel��, E., Vera, R. J. C., Chamani, W., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chanishvili, R. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., Rizzi, N., and Bonnoli, G.

Subjects
electron, galaxies: active, flux: correlation, GeV, radiation mechanisms: non-thermal, 7. Clean energy, MAGIC, GLAST, blazar, gamma ray: VHE, ultraviolet, optical, spectral, TeV, BL Lacertae objects: individual: Mrk 421, X-ray: flux, model: leptonic, Lorentz
Abstract

Astronomy and astrophysics 655, A89 (2021). doi:10.1051/0004-6361/202141004, Aims. We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with a special focus on the multi-band flux correlations.Methods. The dataset has been collected through an extensive multi-wavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina, and Mets��hovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components.Results. The very-high-energy (VHE; E > 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow different patterns, partly due to substantial changes in the Compton dominance for a few days without a simultaneous increase in the X-ray flux (i.e., orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. The peak frequency of the synchrotron bump varies by two orders of magnitude throughout the campaign. Our multi-band correlation study also hints at an anti-correlation between UV-optical and X-ray at a significance higher than 3��. A VHE flare observed on MJD 57788 (2017 February 4) shows gamma-ray variability on multi-hour timescales, with a factor ten increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario. We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors, from �����$_{min}$=2��10$^4$ to �����$_{max}$=6��10$^5$.Key words: galaxies: active / BL Lacertae objects: individual: Mrk 421 / radiation mechanisms: non-thermal��� Light curves and spectral energy distributions data are only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/cat/J/A+A/655/A89������ Corresponding authors: A. Arbet Engels and D. Paneque; e-mail: contact.magic@mpp.mpg.de.��������� Also member of the MAGIC Collaboration.������������ Also member of the FACT Collaboration., Published by EDP Sciences, Les Ulis

238. Intensity interferometry with the MAGIC telescopes

Author

Delgado Mendez, C., Acciari, V. A., Colombo, E., Cortina, J., Diaz, C., Fink, D., Fiori, M., Hassan, T., Jiménez-Martínez, I., Lyard, E., Mangano, S., Mirzoyan, R., Naleto, G., Njoh Ekoume, T., Polo, M., Produit, N., Rodriguez, J. J., Schweizer, T., Walter, R., Wunderlich, C., Zampieri, L., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Contreras, J. L., Covino, S., D Amico, G., D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Yamamoto, T., and Zarić, D.

Subjects
Physics, Interferometry, Optics, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Solar and Stellar Astrophysics, MAGIC (telescope), Astrophysics::Cosmology and Extragalactic Astrophysics, business, Astrophysics::Galaxy Astrophysics, Intensity (physics)
Abstract

Due to their large mirror size, fast response to single photons, sensitivity and telescope baselines in the order of 100 m, Imaging Atmospheric Cherenkov Telescopes are ideally suited to perform intensity interferometry observations. In 2019 a test readout setup was installed in the two 17-m diameter MAGIC telescopes to allow performing interferometry measurements with them. The first on-sky measurements were able to detect correlated intensity fluctuations consistent with the stellar diameters of three different stars: Adhara (ϵ CMa), Benetnasch (η UMa) and Mirzam (β CMa). After the upgrade of the setup in 2021, MAGIC is now equipped with a high-duty-cycle intensity interferometer, already in operation. A technical description of the interferometer and first performance results obtained by measuring several known stellar diameter are presented., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)

242. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Author

van Zuydam, Natalie R, Ahlqvist, Emma, Sandholm, Niina, Deshmukh, Harshal, Rayner, N William, Abdalla, Moustafa, Ladenvall, Claes, Ziemek, Daniel, Fauman, Eric, Robertson, Neil R, Mckeigue, Paul M, Valo, Erkka, Forsblom, Carol, Harjutsalo, Valma, Perna, Annalisa, Rurali, Erica, Marcovecchio, M Loredana, Igo, Robert P, Salem, Rany M, Perico, Norberto, Lajer, Maria, Käräjämäki, Annemari, Imamura, Minako, Kubo, Michiaki, Takahashi, Atsushi, Sim, Xueling, Liu, Jianjun, van Dam, Rob M, Jiang, Guozhi, Tam, Claudia H T, Luk, Andrea O Y, Lee, Heung Man, Lim, Cadmon K P, Szeto, Cheuk Chun, Wing Yee, So, Chan, Juliana C N, Ang, Su Fen, Dorajoo, Rajkumar, Wang, Ling, Clara, Tan Si Hua, Mcknight, Amy-Jayne, Duffy, Seamus, Pezzolesi, Marcus G, Marre, Michel, Gyorgy, Beata, Hadjadj, Samy, Hiraki, Koivula, S, Uggeldahl, T, Forslund, T, Halonen, A, Koistinen, A, Koskiaho, P, Laukkanen, M, Saltevo, J, Tiihonen, M, Forsen, M, Granlund, H, Jonsson, Ac, Nyroos, B, Kinnunen, P, Orvola, A, Salonen, T, Vähänen, A, Paldanius, Kr, Riihelä, M, Ryysy, L, Laukkanen, Kh, Nyländen, P, Sademies, A, Anderson, S, Asplund, B, Byskata, U, Liedes, P, Kuusela, M, Virkkala, T, Nikkola, A, Ritola, E, Niska, Tm, Saarinen, H, Oukko-Ruponen, Se, Virtanen, T, Lyytinen, Va, Kari, Ph, Simonen, T, Kaprio, Sa, Kärkkäinen, J, Rantaeskola, B, Kääriäinen, Tp, Haaga, J, Pietiläinen, Al, Klemetti, S, Nyandoto, T, Rontu, E, Satuli-Autere, S, Toivonen, Kr, Lansimaki, Hv, Ahonen, R, Ivaska-Suomela, M, Jauhiainen, A, Laine, Mm, Pellonpää, T, Puranen, R, Airas, Ma, Laakso, J, Rautavaara, K, Erola, Rm, Jatkola, E, Lönnblad, Tr, Malm, A, Mäkelä, J, Rautamo, E, Hentunen, P, Lagerstam, J, Feodoroff, M, Gordin, D, Heikkilä, O, Hietala, K, Fagerudd, J, Korolainen, M, Kyllönen, L, Kytö, J, Lindh, S, Pettersson-Fernholm, K, Rosengård-Bärlund, M, Sandelin, A, Thorn, L, Tuomikangas, J, Vesisenaho, T, Wadén, J, Sipilä, V, Kalliomäki, Ft, Koskelainen, J, Nikkanen, R, Savolainen, N, Sulonen, H, Valtonen, E, Norvio, L, Hämäläinen, A, Toivanen, E, Parta, Ja, Pirttiniemi, I, Aranko, S, Ervasti, S, Kauppinen-Mäkelin, R, Kuusisto, A, Leppälä, T, Nikkilä, K, Pekkonen, L, Jokelainen, Ks, Kananen, K, Karjalainen, M, Kemppainen, P, Mankinen, Am, Reponen, A, Sankari, M, Suominen, P, Lappalainen, A, Liimatainen, M, Santaholma, J, Aimolahti, A, Huovinen, E, Ilkka, V, Lehtimäki, M, Pälikkö-Kontinen, E, Vanhanen, A, Koskinen, E, Siitonen, T, Huttunen, E, Ikäheimo, R, Karhapää, P, Kekäläinen, P, Laakso, M, Lakka, T, Lampainen, E, Moilanen, L, Tanskanen, S, Niskanen, L, Tuovinen, U, Vauhkonen, I, Voutilainen, E, Rcw, Ma, Chan, Jcn, Huang, Y, Lan, Hy, Lok, S, Tomlinson, B, Tsui, Skw, Yu, W, Yip, Kyl, Chan, Tf, Fan, X, So, Wy, Szeto, Cc, Tang, N, Luk, Ao, Tian, X, Jiang, G, Tam, Cht, Lee, Hm, Lim, Ckp, Chan, Kkh, Xie, F, Acw, Ng, Cheung, Gpy, Yeung, Mw, Mai, S, Zhang, S, Yu, P, Weng, M, Maxwell, Ap, Mcknight, Aj, Savage, Da, Walker, J, Thomas, S, Viberti, Gc, Boulton, Ajm, Marshall, S, Demaine, Ag, Millward, Ba, Bain, Sc, Sandholm, N, Forsblom, C, Harjutsalo, V, Mäkinen, Vp, Ahola, Aj, Dahlström, E, Lehto, M, Lithovius, R, Panduru, Nm, Parkkonen, M, Saraheimo, M, Söderlund, J, Soro-Paavonen, A, Syreeni, A, Thorn, Lm, Tolonen, N, Groop, Ph, Mckay, Gj, Salem, Rm, Isakova, T, Palmer, C, Guiducci, C, Taylor, A, Mirel, Db, Williams, Ww, Hirschhorn, Jn, Florez, Jc, Brennan, Ep, Sadlier, Dm, Martin, F, Godson, C, Mayer, L, Gubitosi-Klug, R, Bourne, P, Schutta, M, Lackaye, Me, Gregory, Ns, Kruger, D, Jones, Jk, Bhan, A, Golden, E, Aiello, L, Larkin, M, Nathan, D, Ziegler, G, Caulder, S, Pittman, C, Luttrell, L, Lopes-Virella, M, Johnson, M, Gunyou, K, Bergenstal, R, Vittetoe, B, Sivitz, W, Flaherty, N, Bantle, J, Hitt, S, Goldstein, D, Hainsworth, D, Cimino, L, Orchard, T, Wigley, C, Dagogo-Jack, S, Strowig, S, Raskin, P, Barnie, A, Zinman, B, Fahlstrom, R, Palmer, J, Harth, J, Driscoll, M, Mcdonald, C, Lipps Hagan, J, May, M, Levandoski, L, White, N, Gatcomb, P, Tamborlane, W, Adelman, D, Colson, S, Molitch, M, Lorenzi, G, Mudaliar, S, Johnsonbaugh, S, Miller, R, Canady, J, Schade, D, Bernal, Ml, Malone, J, Morrison, A, Martin, C, Herman, W, Pop-Busui, R, Cowie, C, Leschek, E, Cleary, P, Lachin, J, Braffett, B, Steffes, M, Arends, V, Blodi, B, Danis, R, Lawrence, D, Wabers, H, Soliman, E, Zhang, Zm, Campbell, C, Hensley, S, Keasler, L, Mark, M, Albertini, M, Boustany, C, Ehlgen, A, Gerl, M, Huber, J, Schölch, C, Zimdahl-Gelling, H, Groop, L, Agardh, E, Ahlqvist, E, Ajanki, T, Al Maghrabi, N, Almgren, P, Apelqvist, J, Bengtsson, E, Berglund, L, Björckbacka, H, Blom-Nilsson, U, Borell, M, Burström, A, Cilio, C, Cinthio, M, Dreja, K, Dunér, P, Engelbertsen, D, Fadista, J, Gomez, M, Goncalves, I, Hedblad, B, Hultgårdh, A, Johansson, Me, Kennbäck, C, Kravic, J, Ladenvall, C, Lernmark, Å, Lindholm, E, Ling, C, Luthman, H, Melander, O, Neptin, M, Nilsson, J, Nilsson, P, Nilsson, T, Nordin, G, Orho-Melander, M, Ottoson-Laakso, E, Persson, A, Persson, M, Persson, Må, Postma, J, Pranter, E, Rattik, S, Sterner, G, Tindberg, L, Wigren, M, Zetterqvist, A, Åkerlund, M, Ostling, G, Kanninen, T, Ahonen-Bishopp, A, Eliasson, A, Herrala, T, Tikka-Kleemola, P, Hamsten, A, Betsholtz, C, Björkholm, A, Foroogh, F, Genové, G, Gertow, K, Gigante, B, He, B, Leander, K, Mcleod, O, Nastase-Mannila, M, Patrakka, J, Silveira, A, Strawbridge, R, Tryggvason, K, Vikström, M, Ohrvik, J, Österholm, Am, Thorand, B, Gieger, C, Grallert, H, Ludwig, T, Nitz, B, Schneider, A, Wang-Sattler, R, Zierer, A, Remuzzi, G, Benigni, A, Donadelli, R, Lesti, Md, Noris, M, Perico, N, Perna, A, Piras, R, Ruggenenti, P, Rurali, E, Dunger, D, Chassin, L, Dalton, N, Deanfield, J, Horsford, J, Rice, C, Rudd, J, Walker, N, Whitehead, K, Wong, M, Colhoun, H, Adams, F, Akbar, T, Belch, J, Deshmukh, H, Dove, F, Ellingford, A, Farran, B, Ferguson, M, Henderson, G, Houston, G, Khan, F, Leese, G, Liu, Y, Livingstone, S, Looker, H, Mccann, M, Mcgurnaghan, S, Morris, A, Newton, D, Pearson, E, Reekie, G, Smith, N, Shore, A, Aizawa, K, Ball, C, Bellenger, N, Casanova, F, Frayling, T, Gates, P, Gooding, K, Hattersley, A, Ling, R, Mawson, D, Shandas, R, Strain, D, Thorn, C, Smith, U, Hammarstedt, A, Häring, H, Pedersen, O, Sesti, G, Fagerholm, E, Toppila, I, Valo, E, Salomaa, V, Havulinna, A, Kristiansson, K, Okamo, P, Peltola, T, Perola, M, Pietilä, A, Ripatti, S, Taimi, M, Ylä-Herttuala, S, Babu, M, Dijkstra, M, Gurzeler, E, Huusko, J, Kholová, I, Merentie, M, Poikolainen, M, Mccarthy, M, Groves, C, Juliusdottir, T, Karpe, F, Lagou, V, Rayner, W, Robertson, N, van Zuydam, N, Cobelli, C, Di Camillo, B, Finotello, F, Sambo, F, Toffolo, G, Trifoglio, E, Bellazzi, R, Barbarini, N, Bucalo, M, Larizza, C, Magni, P, Malovini, A, Marini, S, Mulas, F, Quaglini, S, Sacchi, L, Vitali, F, Ferrannini, E, Boldrini, B, Kozakova, M, Mari, A, Morizzo, C, Mota, L, Natali, A, Palombo, C, Venturi, E, Walker, M, Patrono, C, Pagliaccia, F, Rocca, B, Nuutila, P, Haukkala, J, Knuuti, J, Roivainen, A, Saraste, A, Mckeague, P, Colombo, M, Steckel-Hamann, B, Bokvist, K, Shankar, S, Thomas, M, Gan, Lm, Heinonen, S, Jönsson-Rylander, Ac, Momo, R, Schnecke, V, Unwin, R, Walentinsson, A, Whatling, C, Nogoceke, E, Pacheco, Gd, Formentini, I, Schindler, T, Tortoli, P, Bassi, L, Boni, E, Dallai, A, Guidi, F, Lenge, M, Matera, R, Ramalli, A, Ricci, S, Viti, J, Jablonka, B, Crowther, D, Gassenhuber, J, Hess, S, Hubschle, T, Juretschke, Hp, Rutten, H, Sadowski, T, Wohlfart, P, Brosnan, J, Clerin, V, Fauman, E, Hyde, C, Malarstig, A, Pullen, N, Tilley, M, Tuthill, T, Vangjeli, C, Linda T, Ziemek D., Ahluwalia, Tarunveer S, Almgren, Peter, Schulz, Christina-Alexandra, Orho-Melander, Marju, Linneberg, Allan, Christensen, Cramer, Witte, Daniel R, Grarup, Niels, Brandslund, Ivan, Melander, Olle, Paterson, Andrew D, Tregouet, David, Maxwell, Alexander P, Lim, Su Chi, Ronald C W, Ma, Tai, E Shyong, Maeda, Shiro, Lyssenko, Valeriya, Tuomi, Tiinamaija, Krolewski, Andrzej S, Rich, Stephen S, Hirschhorn, Joel N, Florez, Jose C, Dunger, David, Pedersen, Oluf, Hansen, Torben, Rossing, Peter, Remuzzi, Giuseppe, Brosnan, Mary Julia, Palmer, Colin N A, Groop, Per-Henrik, Colhoun, Helen M, Groop, Leif C, Mccarthy, Mark, I, Palombo, Carlo, Clinicum, Diabetes and Obesity Research Program, Research Programs Unit, Nefrologian yksikkö, Department of Medicine, Institute for Molecular Medicine Finland, Tiinamaija Tuomi Research Group, Endokrinologian yksikkö, Per Henrik Groop / Principal Investigator, Leif Groop Research Group, HUS Abdominal Center, HUS Internal Medicine and Rehabilitation, and Lee Kong Chian School of Medicine (LKCMedicine)

Subjects
0301 basic medicine, Male, endocrine system diseases, Endocrinology, Diabetes and Metabolism, LOCI, Genome-wide association study, Type 2 diabetes, Bioinformatics, Kidney Failure, 0302 clinical medicine, Genome-wide analysis, 80 and over, Diabetic Nephropathies, Renal Insufficiency, Chronic, Genome-wide analysis, Type 2 Diabetes, Aged, 80 and over, RISK, INSULIN-RESISTANCE, diabetes, Diabetes, STAGE RENAL-DISEASE, Single Nucleotide, Middle Aged, Type 2 Diabetes, SUSCEPTIBILITY GENES, Adult, Aged, Case-Control Studies, Diabetes Mellitus, Type 2, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Failure, Chronic, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic, OBESITY, BIOLOGICAL PATHWAYS, nephropathy, Medical genetics, Type 2, kidney, medicine.medical_specialty, Diabetic Nephropathies/epidemiology, Settore BIO/14 - FARMACOLOGIA, Renal Insufficiency, Chronic/complications, NEPHROPATHY, SNP, 030209 endocrinology & metabolism, Nephropathy, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Diabetes mellitus, Journal Article, Diabetes Mellitus, Internal Medicine, medicine, Medicine [Science], Polymorphism, Diabetic Kidney Disease, METAANALYSIS, Genetic heterogeneity, business.industry, Diabetes Mellitus, Type 2/complications, association, Case-control study, nutritional and metabolic diseases, Kidney Failure, Chronic/complications, FAT DISTRIBUTION, medicine.disease, 030104 developmental biology, 3121 General medicine, internal medicine and other clinical medicine, Microalbuminuria, genetic, business
Abstract

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10-8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD. ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore)

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243. Cross-calibration and combined analysis of the CTA-LST prototype and the MAGIC telescopes

Author

Ohtani, Y., Berti, A., Depaoli, D., Di Pierro, F., Green, D., Heckmann, L., Hütten, M., Inada, T., López-Coto, R., Medina, E., Moralejo, A., Morcuende, D., Pirola, G., Strzys, M., Suda, Y., Vovk, I., Abe, H., Aguasca, A., Agudo, I., Antonelli, L. A., Aramo, C., Armstrong, T., Artero, M., Asano, K., Ashkar, H., Aubert, P., Baktash, A., Bamba, A., Baquero Larriva, A., Baroncelli, L., Barres Almeida, U., Barrio, J. A., Batkovic, I., Becerra González, J., Bernardos, M. I., Biederbeck, N., Bigongiari, C., Blanch, O., Bonnoli, G., Bordas, P., Bose, D., Bulgarelli, A., Burelli, I., Buscemi, M., Cardillo, M., Caroff, S., Carosi, A., Cassol, F., Cerruti, M., Chai, Y., Cheng, K., Chikawa, M., Chytka, L., Contreras, J. L., Cortina, J., Costantini, H., Dalchenko, M., Angelis, A., Bony Lavergne, M., Deleglise, G., Delgado, C., Delgado Mengual, J., Della Volpe, D., Di Venere, L., Díaz, C., Dominik, R. M., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsässer, D., Emery, G., Escudero, J., Fiasson, A., Foffano, L., Fonseca, M. V., Freixas Coromina, L., Fukami, S., Fukazawa, Y., Garcia, E., Garcia López, R., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Grespan, P., Gunji, S., Hackfeld, J., Hadasch, D., Hahn, A., Hassan, T., Hayashi, K., Heller, M., Herrera Llorente, J., Hirotani, K., Hoffmann, D., Horns, D., Houles, J., Hrabovsky, M., Hrupec, D., Hui, D., Inome, Y., Iori, M., Ishio, K., Iwamura, Y., Jacquemont, M., Jimenez Martinez, I., Jouvin, L., Jakub Jurysek, Kagaya, M., Karas, V., Katagiri, H., Kataoka, J., Kerszberg, D., Kobayashi, Y., Kong, A., Kubo, H., Kushida, J., Lamanna, G., Lamastra, A., Le Flour, T., Longo, F., López-Moya, M., López-Oramas, A., Luque-Escamilla, P. L., Majumdar, P., Makariev, M., Mandat, D., Manganaro, M., Mannheim, K., Mariotti, M., Marquez, P., Marsella, G., Martí, J., Martinez, O., Martínez, G., Martínez, M., Marusevec, P., Mas, A., Maurin, G., Mazin, D., Mestre Guillen, E., Micanovic, S., Miceli, D., Miener, T., Miranda, J. M., Miranda, L. D. M., Mirzoyan, R., Mizuno, T., Molina, E., Montaruli, T., Monteiro, I., Moretti, E., Morselli, A., Mrakovcic, K., Murase, K., Nagai, A., Nakamori, T., Nickel, L., Nieto, D., Nievas, M., Nishijima, K., Noda, K., Nosek, D., Nöthe, M., Nozaki, S., Ohishi, M., Oka, T., Okazaki, N., Okumura, A., Orito, R., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Pech, M., Pecimotika, M., Poireau, V., Polo, M., Prandini, E., Prast, J., Priyadarshi, C., Prouza, M., Rando, R., Rhode, W., Ribó, M., Rizi, V., Rugliancich, A., Ruiz, J. E., Saito, T., Sakurai, S., Sanchez, D. A., Šarić, T., Saturni, F. G., Scherpenberg, J., Schleicher, B., Schubert, J. L., Schussler, F., Schweizer, T., Seglar Arroyo, M., Shellard, R. C., Sitarek, J., Sliusar, V., Spolon, A., Strišković, J., Sunada, Y., Tajima, H., Takahashi, M., Takahashi, H., Takata, J., Takeishi, R., Tam, P. H. T., Tanaka, S. J., Tateishi, D., Tejedor, L. A., Temnikov, P., Terada, Y., Terzic, T., Teshima, M., Tluczykont, M., Tokanai, F., Torres, D. F., Travnicek, P., Truzzi, S., Vacula, M., Vázquez Acosta, M., Verguilov, V., Verna, G., Viale, I., Vigorito, C. F., Vitale, V., Vuillaume, T., Walter, R., Will, M., Yamamoto, T., Yamazaki, R., Yoshida, T., Yoshikoshi, T., Zarić, D., Acciari, V. A., Ansoldi, S., Arbet Engels, A., Baack, D., Babić, A., Baquero, A., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Besenrieder, J., Bhattacharyya, W., Biland, A., Bökenkamp, H., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Covino, S., D Amico, G., D Elia, V., Da Vela, P., Dazzi, F., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Do Souto Espiñeira, E., Fallah Ramazani, V., Fattorini, A., Font, L., Fruck, C., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Green, J. G., Herrera, J., Hoang, J., Jiménez Martínez, I., Jormanainen, J., Karjalainen, M., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Mallamaci, M., Maneva, G., Maraschi, L., Menchiari, S., Mender, S., Moreno, V., Neustroev, V., Nigro, C., Nilsson, K., Paiano, S., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Puljak, I., Rico, J., Righi, C., Sahakyan, N., Satalecka, K., Schmidt, K., Šnidarić, I., Sobczynska, D., Stamerra, A., Strom, D., Surić, T., Tavecchio, F., Tosti, L., Tutone, A., Ubach, S., Vanzo, G., Ventura, S., and Wunderlich, C.

Subjects
Physics, Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, FOS: Physical sciences, Cosmic ray, Cherenkov Telescope Array, law.invention, Telescope, Crab Nebula, Air shower, law, Observatory, MAGIC (telescope), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Computer Science::Distributed, Parallel, and Cluster Computing
Abstract

The Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory, which will consist of three kinds of telescopes of different sizes. Among those, the Large Size Telescope (LST) will be the most sensitive in the low energy range starting from 20 GeV. The prototype LST (LST-1) proposed for CTA was inaugurated in October 2018 in the northern hemisphere site, La Palma (Spain), and is currently in its commissioning phase. MAGIC is a system of two gamma-ray Cherenkov telescopes of the current generation, located approximately 100 m away from LST-1, that have been operating in stereoscopic mode since 2009. Since LST-1 and MAGIC can observe the same air shower events, we can compare the brightness of showers, estimated energies of gamma rays, and other parameters event by event, which can be used to cross-calibrate the telescopes. Ultimately, by performing combined analyses of the events triggering the three telescopes, we can reconstruct the shower geometry more accurately, leading to better energy and angular resolutions, and a better discrimination of the background showers initiated by cosmic rays. For that purpose, as part of the commissioning of LST-1, we performed joint observations of established gamma-ray sources with LST-1 and MAGIC. Also, we have developed Monte Carlo simulations for such joint observations and an analysis pipeline which finds event coincidence in the offline analysis based on their timestamps. In this work, we present the first detection of an astronomical source, the Crab Nebula, with combined observation of LST-1 and MAGIC. Moreover, we show results of the inter-telescope cross-calibration obtained using Crab Nebula data taken during joint observations with LST-1 and MAGIC., Comment: 11 pages, 4 figures, Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021), Berlin, Germany

244. Search for Gamma-ray Line emission from Dark Matter annihilation in the Galactic Centre with the MAGIC telescopes

Author

Inada, T., Kerszberg, D., Hütten, M., Teshima, M., Rico, J., Ninci, D., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Almeida, U. B., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Oliveira Fraga, B. M., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.

245. Protons Spectrum from the MAGIC Telescopes data

Author

Temnikov, P., Verguilov, V., Maneva, G., Mirzoyan, R., Baack, D., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D’amico, G., D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.

247. Discovery of TXS 1515-273 at VHE gamma rays and modelling of its Spectral Energy Distribution

Author

D Ammando, F., Nabizadeh, A., Bissaldi, E., Orienti, M., Cutini, S., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D Amico, G., D Elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.

248. Multi-messenger characterization of Mrk501 during historically low X-ray and gamma-ray activity

Author

Heckmann, L., Paneque, D., Gasparyan, S., Cerruti, M., Sahakyan, N., Arbet-Engels, A., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D’amico, G., D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Dorota Sobczynska, Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., and Zarić, D.

249. Studying the long-term spectral and temporal evolution of 1ES1959+650

Author

Sakurai, S., Bhattacharyya, W., Dorner, D., Grespan, P., Morcuende, D., Prandini, E., Schleicher, B., Takahashi, M., Nabatame, Y., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., Barres Almeida, U., Barrio, J. A., Batković, I., Becerra González, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhatacharya, W., Bigongiari, C., Biland, A., Blanch, O., Bökenkamp, H., Bonnoli, G., Bošnjak, Ž, Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Giacomo D'Amico, D’elia, V., Da Vela, P., Dazzi, F., Angelis, A., Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Bario, J. A., Do Souto Espiñeira, E., Dominis Prester, D., Donini, A., Walter, R., Doro, M., Elsaeser, D., Fallah Ramazani, V., Fattorini, A., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., García López, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hütten, M., Inada, T., Ishio, K., Iwamura, Y., Jiménez Martínez, I., Jormanainen, J., Jouvin, L., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Machado Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Manheim, K., Maraschi, L., Mariotti, M., Martínez, M., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Neise, D., Moreno, V., Moretti, E., Nakamori, T., Nava, L., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Peñil, P., Persic, M., Pihet, M., Prada Moroni, P. G., Noethe, M., Priyadarshi, C., Puljak, I., Rhade, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Paravac, A., Satalecka, K., Saturni, F. G., Rhode, W., Schmidt, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Sliusar, V., Takeishi, R., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., Arbot Engels, A., Back, D., Balbo, M., Billand, A., Bretz, T., Buss, J., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Kalenski, A., Mannheim, K., and Mitchell, A.

Subjects
Physics, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astrophysics, Synchrotron, law.invention, Crab Nebula, law, Sky, MAGIC (telescope), Neutrino, Blazar, media_common, Flare
Abstract

The high-frequency peaked BL Lac type object (HBL) 1ES 1959+650 is one of the brightest blazars in the very-high-energy (VHE, E≳100 GeV) gamma-ray sky. HBLs have been proposed as possible neutrino emitters implying the presence of hadrons in the emission mechanisms. In 2002, AMANDA reported neutrino candidates from this source simultaneously observed with a gamma-ray flaring activity without an X-ray emission enhancement, interpreted as an orphan flare. Standard one-zone synchrotron self-Compton (SSC) emission models cannot explain this behavior. The MAGIC telescopes have been observing 1ES 1959+650 since 2004. An extreme outburst triggered by multiwavelength observations reaching 300% of the Crab nebula flux level above 300 GeV was detected in 2016. Leptonic and hadronic models are equally successful in describing the observed emission. To study the long-term behavior and the characteristics in different emission states of 1ES 1959+650, we have densely monitored it since 2017 for more than 300 hours. Together with the FACT monitoring (more than 2000 hours since 2012), this is the most intense monitoring for any blazar after Mrk421 and Mrk501 in the VHE range. The monitoring shows a decline of the VHE flux with occasional flaring episodes reaching in 2019 a low-state emission corresponding to 10% of the Crab nebula. We present the long-term monitoring study results using multiwavelength data from MAGIC, FACT, Fermi-LAT, Swift, OVRO, and Tuorla. Lastly, we discuss the differences in the broadband spectral energy distributions between the flaring states from 2016 and the low state in 2019., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)

250. First detection of VHE gamma-ray emission from TXS 1515���273, study of its X-ray variability and spectral energy distribution

Author

Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Artero, M., Asano, K., Baack, D., Babi��, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batkovi��, I., Gonz��lez, J. Becerra, Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bo��njak, ��., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espi��eira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. Fallah, Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., L��pez, R. J. Garc��a, Garczarczyk, Markus, Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi��, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H��tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jim��nez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L��pez-Coto, R., L��pez-Moya, M., L��pez-Oramas, A., Loporchio, S., Fraga, B. Machado de Oliveira, Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart��nez, M., Mazin, D., Menchiari, S., Mender, S., Mi��anovi��, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti��, L., Pe��il, P., Perennes, C., Persic, M., Moroni, P. G. Prada, Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Rib��, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., ��nidari��, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri��, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi��, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Bissaldi, E., Bonnoli, G., Cutini, S., D'Ammando, F., Nabizadeh, A., Marchini, A., and Orienti, M.

Subjects
Radiation mechanisms: non-thermal, objects: individual: TXS 1515���273, galaxies: active, 7. Clean energy
Abstract

Monthly notices of the Royal Astronomical Society 507(1), 1528 - 1545 (2021). doi:10.1093/mnras/stab1994, We report here on the first multiwavelength (MWL) campaign on the blazar TXS 1515���273, undertaken in 2019 and extending from radio to very-high-energy gamma-rays (VHE). Up until now, this blazar had not been the subject of any detailed MWL observations. It has a rather hard photon index at GeV energies and was considered a candidate extreme high-synchrotron-peaked source. MAGIC observations resulted in the first-time detection of the source in VHE with a statistical significance of 7.6��. The average integral VHE flux of the source is 6 �� 1 per cent of the Crab nebula flux above 400 GeV. X-ray coverage was provided by Swift-XRT, XMM���Newton, and NuSTAR. The long continuous X-ray observations were separated by ���9 h, both showing clear hour scale flares. In the XMM���Newton data, both the rise and decay time-scales are longer in the soft X-ray than in the hard X-ray band, indicating the presence of a particle cooling regime. The X-ray variability time-scales were used to constrain the size of the emission region and the strength of the magnetic field. The data allowed us to determine the synchrotron peak frequency and classify the source as a flaring high, but not extreme synchrotron-peaked object. Considering the constraints and variability patterns from the X-ray data, we model the broad-band spectral energy distribution. We applied a simple one-zone model, which could not reproduce the radio emission and the shape of the optical emission, and a two-component leptonic model with two interacting components, enabling us to reproduce the emission from radio to VHE band., Published by Oxford Univ. Press, Oxford

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