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203. Recent Development Status of PoGOLite

Author

Kurita, K., Kanai, Y., Ueno, M., Kataoka, J., Kawai, N., Umeki, Y., Yoshida, H., Tanaka, T., Takahashi, H., Mizuno, T., Fukazawa, Y., Tajima, H., Kamae, T., Madejski, G., Varner, G., Kiss, M., Carlson, P., Klamra, W., Pearce, Mark, Ryde, F., Larsson, S., Florén, H. -G, Olofsson, G., Bogaert, G., Takahashi, T., Gunji, S., Collaboration, The PoGOLite, Kurita, K., Kanai, Y., Ueno, M., Kataoka, J., Kawai, N., Umeki, Y., Yoshida, H., Tanaka, T., Takahashi, H., Mizuno, T., Fukazawa, Y., Tajima, H., Kamae, T., Madejski, G., Varner, G., Kiss, M., Carlson, P., Klamra, W., Pearce, Mark, Ryde, F., Larsson, S., Florén, H. -G, Olofsson, G., Bogaert, G., Takahashi, T., Gunji, S., and Collaboration, The PoGOLite

Abstract

QC 20120214

Published
2009

204. The PoGOLite balloon-borne soft gamma-ray polarimeter

Author

Kiss, M., Larsson, Stefan, Bettolo, C., Bogaert, G., Florén, Hans-Gustav, Fukazawa, Y., Gunji, S., Hjalmarsdotter, Linnea, Kamae, T., Kanai, Y., Kataoka, J., Kawai, N., Klamra, W., Kurita, K., Madejski, G., Olofsson, Göran, Pearce, Mark, Ryde, Felix, Rydström, S., Tajima, H., Takahashi, H., Takahashi, T., Tanaka, T., Ueno, M., Umeki, Y., Varner, G., Yoshida, H., Kiss, M., Larsson, Stefan, Bettolo, C., Bogaert, G., Florén, Hans-Gustav, Fukazawa, Y., Gunji, S., Hjalmarsdotter, Linnea, Kamae, T., Kanai, Y., Kataoka, J., Kawai, N., Klamra, W., Kurita, K., Madejski, G., Olofsson, Göran, Pearce, Mark, Ryde, Felix, Rydström, S., Tajima, H., Takahashi, H., Takahashi, T., Tanaka, T., Ueno, M., Umeki, Y., Varner, G., and Yoshida, H.

Abstract

Linearly polarized radiation in the hard X-ray/soft gamma-ray band is expected from a large variety of astronomical sources. We discuss the importance of polarimetric studies for several classes of sources-pulsars, accreting black holes, magnetic neutron stars and jets from active galaxies-and then describe PoGOLite, a balloon-borne instrument which is currently under construction and will be able to measure the polarization of electromagnetic radiation from such extra-solar objects in the energy range 25-80 keV.

Published
2008
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205. PoGOLite - A high sensitivity balloon-borne soft gamma-ray polarimeter

Author

Kamae, T. Y., Andersson, V., Arimoto, M., Axelsson, M., Bettolo, C. M., Bjornsson, C. I., Bogaert, G., Carlson, P., Craig, W., Ekeberg, T., Engdegdrd, O., Fukazawa, Y., Gunji, S., Hjalmarsdotter, L., Iwan, B., Kanai, Y., Kataoka, J., Kawai, N., Kazejev, J., Kiss, M., Klamra, W., Larsson, S., Madejski, G., Mizuno, T., Ng, J., Pearce, M., Ryde, F., Suhonen, M., TaJima, H., Takahashi, H., Takahashi, T., Tanaka, T., Thurston, T., Ueno, M., Varneri, G., Yamamoto, K., Yamashita, Y., Ylinen, T., Yoshida, H., Kamae, T. Y., Andersson, V., Arimoto, M., Axelsson, M., Bettolo, C. M., Bjornsson, C. I., Bogaert, G., Carlson, P., Craig, W., Ekeberg, T., Engdegdrd, O., Fukazawa, Y., Gunji, S., Hjalmarsdotter, L., Iwan, B., Kanai, Y., Kataoka, J., Kawai, N., Kazejev, J., Kiss, M., Klamra, W., Larsson, S., Madejski, G., Mizuno, T., Ng, J., Pearce, M., Ryde, F., Suhonen, M., TaJima, H., Takahashi, H., Takahashi, T., Tanaka, T., Thurston, T., Ueno, M., Varneri, G., Yamamoto, K., Yamashita, Y., Ylinen, T., and Yoshida, H.

Abstract

We describe a new balloon-borne instrument (PoGOLite) capable of detecting 10% polarisation from 200 mCrab point-like sources between 25 and 80 keV in one 6-h flight. Polarisation measurements in the soft gamma-ray band are expected to provide a powerful probe into high energy emission mechanisms as well as the distribution of magnetic fields, radiation fields and interstellar matter. Synchrotron radiation, inverse Compton scattering and propagation through high magnetic fields are likely to produce high degrees of polarisation in the energy band of the instrument. We demonstrate, through tests at accelerators, with radioactive sources and through computer simulations, that PoGOLite will be able to detect degrees of polarisation as predicted by models for several classes of high energy sources. At present, only exploratory polarisation measurements have been carried out in the soft gamma-ray band. Reduction of the large background produced by cosmic-ray particles while securing a large effective area has been the greatest challenge. PoGOLite uses Compton scattering and photo-absorption in an array of 217 well-type phoswich detector cells made of plastic and BGO scintillators surrounded by a BGO anticoincidence shield and a thick polyethylene neutron shield. The narrow Held of view (FWHM = 1.25 msr, 2.0 deg x 2.0 deg) obtained with detector cells and the use of thick background shields warrant a large effective area for polarisation measurements (similar to 228 cm(2) at E = 40 keV) without sacrificing the signal-to-noise ratio. Simulation studies for an atmospheric overburden of 3-4 g/cm(2) indicate that neutrons and gamma-rays entering the PDC assembly through the shields are dominant backgrounds. Off-line event selection based on recorded phototube waveforms and Compton kinematics reduce the background to that expected for a similar to 100 mCrab source between 25 and 50 keV. A 6-h observation of the Crab pulsar will differentiate between the Polar Cap/Slot Gap, Out, Kamae, Tuneyoshi Andersson, Viktor Arimoto, Makoto Axelsson, Magnus Bettolo, Cecilia Marini Bjornsson, Claes-Ingvar Bogaert, Gilles Carlson, Per Craig, William Ekeberg, Tomas Engdegdrd, Olle Fukazawa, Yasushi Gunji, Shuichi Hjalmarsdotter, Linnea Iwan, Bianca Kanai, Yoshikazu Kataoka, Jun Kawai, Nobuyuki Kazejev, Jaroslav Kiss, Mozsi Klamra, Wlodzimierz Larsson, Stefan Madejski, Grzegorz Mizuno, Tsunefumi Ng, Johnny Pearce, Mark Ryde, Felix Suhonen, Markus TaJima, Hiroyasu Takahashi, Hiromitsu Takahashi, Tadayuki Tanaka, Takuya Thurston, Timothy Ueno, Masaru Varneri, Gary Yamamoto, Kazuhide Yamashita, Yuichiro Ylinen, Tomi Yoshida, Hiroaki

Published
2008

210. Data acquisition system for the PoGOLite astronomical hard X-ray polarimeter

Author

Tanaka, T., Arimoto, M., Axelsson, M., Bjornsson, C. I., Bogaert, G., Carlson, P., Cooney, M., Craig, W., Engdegard, O., Fukazawa, Y., Gunji, S., Hjalmarsdotter, L., Kamae, T., Kanai, Y., Kataoka, J., Katsuta, J., Kawai, N., Kazejev, J., Kiss, M., Klamra, W., Larsson, S., Madejski, G., Bettolo, C. M., Mizuno, T., Ng, J., Nomachi, M., Odaka, H., Pearce, M., Ruckman, L., Ryde, F., Tajima, H., Takahashi, H., Takahashi, T., Thurston, T., Ueno, M., Varner, G., Ylinen, Tomi, Yoshida, H., Yuasa, T., Tanaka, T., Arimoto, M., Axelsson, M., Bjornsson, C. I., Bogaert, G., Carlson, P., Cooney, M., Craig, W., Engdegard, O., Fukazawa, Y., Gunji, S., Hjalmarsdotter, L., Kamae, T., Kanai, Y., Kataoka, J., Katsuta, J., Kawai, N., Kazejev, J., Kiss, M., Klamra, W., Larsson, S., Madejski, G., Bettolo, C. M., Mizuno, T., Ng, J., Nomachi, M., Odaka, H., Pearce, M., Ruckman, L., Ryde, F., Tajima, H., Takahashi, H., Takahashi, T., Thurston, T., Ueno, M., Varner, G., Ylinen, Tomi, Yoshida, H., and Yuasa, T.

Abstract

The PoGOLite is a new balloon-borne instrument to measure the polarization of hard X-rays/soft gamma-rays in the 25-80 keV energy range for the first time. In order to detect the polarization, PoGOLite measures the azimuthal angle asymmetry of Compton scattering and the subsequent photo-absorption in an array of detectors. This array consists of 217 well-type phoswich detector cells (PDCs) surrounded by a side anti-coincidence shield (SAS) composed of 54 segments of BGO crystals. At balloon altitude, the intensity of backgrounds due to cosmic-ray charged particles, atmospheric gamma-rays and neutrons is extremely high, typically a few hundred Hz per unit. Hence the data acquisition (DAQ) system of PoGOLite is required to handle more than 270 signals simultaneously, and detect weak signals from astrophysical objects (100mCrab, 1.5 cs(-1) in 25-80 keV) under such a severe environment. We have developed a new DAQ system consisting of front-end electronics, waveform digitizer, Field Programmable Gate Array (FPGA) and a microprocessor. In this system, all output signals of PDC / SAS are fed into individual charge-sensitive amplifier and then digitized to 12 bit accuracy at 24 MSa/s by pipelined analog to digital converters. A DAQ board for the PDC records waveforms which will be examined in an off-line analysis to distinguish signals from the background events and measure the energy spectrum and polarization of targets. A board for the SAS records hit pattern to be used for background rejection. It also continuously records a pulse-height analysis (PHA) histogram to monitor incident background flux. These basic functions of the DAQ system were verified in a series of beam tests., Tanaka, T. Arimoto, M. Axelsson, M. Bjornsson, C.-I. Bogaert, G. Carlson, P. Cooney, M. Craig, W. Engdegard, O. Fukazawa, Y. Gunji, S. Hjalmarsdotter, L. Kamae, T. Kanai, Y. Kataoka, J. Katsuta, J. Kawai, N. Kazejev, J. Kiss, M. Klamra, W. Larsson, S. Madejski, G. Bettolo, C. Marini Mizuno, T. Ng, J. Nomachi, M. Odaka, H. Pearce, M. Ruckman, L. Ryde, F. Tajima, H. Takahashi, H. Takahashi, T. Thurston, T. Ueno, M. Varner, G. Ylinen, T. Yoshida, H. Yuasa, T. IEEE Nuclear Science Symposium/Medical Imaging Conference OCT 26-NOV 03, 2007 Honolulu, HI

Published
2007
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211. Human herpesvirus 8 in classic Kaposi sarcoma

Author

Lajos Kemény, Kiss M, Gyulai R, As, Kenderessy, Adám E, Nagy F, and Dobozy A

Subjects
Aged, 80 and over, CD4-Positive T-Lymphocytes, CD3 Complex, T-Lymphocytes, Herpesvirus 8, Human, Humans, Lymphocyte Count, CD8-Positive T-Lymphocytes, Middle Aged, Sarcoma, Kaposi, Aged
Abstract

Recent studies suggest the role of a new human herpesvirus (HHV8) in the pathogenesis of different forms of Kaposi sarcoma (KS). In the present work we investigated the presence of HHV8 sequences in KS tumour tissues from patient with classic KS. Since clear evidences point to the role of immune suppression in the development of AIDS-associated KS or patients receiving immunosuppressive therapy, immunological investigations were also performed. We could show a highly consequent association of HHV8 sequences with classic KS in the large series of patients supporting our previous findings that this virus might be in some way involved in the pathogenesis of this tumour. In addition immunological examination of the patients revealed a mild decrease in the CD4 positive cell number, a significantly reduced CD4/CD8 ratio, a diminished PHA reactivity and leukocyte migration factor production of lymphocytes. The changes observed in the present study are similar, but much less pronounced than those may be observed in HIV infection.

Published
1996

213. Rad52 SUMOylation affects the efficiency of the DNA repair

Author

Altmannova, V., primary, Eckert-Boulet, N., additional, Arneric, M., additional, Kolesar, P., additional, Chaloupkova, R., additional, Damborsky, J., additional, Sung, P., additional, Zhao, X., additional, Lisby, M., additional, Krejci, L., additional, Colavito, S., additional, Macris-Kiss, M., additional, Seong, C., additional, Gleeson, O., additional, Greene, E. C., additional, and Klein, H. L., additional

Published
2012
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220. Poster session V * Saturday 11 December 2010, 08:30-12:30

Author

Pham, Q. H., primary, Von Lueder, T. G., additional, Namtvedt, S. K., additional, Rosjo, H., additional, Omland, T., additional, Steine, K., additional, Timoteo, A. T., additional, Mota Carmo, M., additional, Simoes, M., additional, Branco, L. M., additional, Ferreira, R. C., additional, Kato, R., additional, Ito, J., additional, Tahara, T., additional, Yokoyama, Y., additional, Ashikaga, T., additional, Satoh, Y., additional, Na, J. O., additional, Hong, H. E., additional, Kim, M. N., additional, Shin, S. Y., additional, Choi, C. U., additional, Kim, E. J., additional, Rha, S. W., additional, Park, C. G., additional, Seo, H. S., additional, Oh, D. J., additional, Ticulescu, R., additional, Brigido, S., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Carerj, S., additional, Nicolosi, G. L., additional, Antonini-Canterin, F., additional, Onaindia Gandarias, J. J., additional, Romero, A., additional, Laraudogoitia, E., additional, Velasco, S., additional, Quintana, O., additional, Cacicedo, A., additional, Rodriguez, I., additional, Alarcon, J. A., additional, Gonzalez, J., additional, Lekuona, I., additional, Subinas, A., additional, Abdula, G., additional, Lund, L. H., additional, Winter, R., additional, Brodin, L., additional, Sahlen, A., additional, Masaki, M., additional, Cha, Y. M., additional, Yuasa, T., additional, Dong, K., additional, Dong, Y. X., additional, Mankad, S. V., additional, Oh, J. K., additional, Vallet, F., additional, Lequeux, B., additional, Diakov, C., additional, Sosner, P., additional, Christiaens, L., additional, Coisne, D., additional, Kihara, C., additional, Murata, K., additional, Wada, Y., additional, Uchida, K., additional, Ueyama, T., additional, Okuda, S., additional, Susa, T., additional, Matsuzaki, M., additional, Cho, E. J., additional, Choi, K. Y., additional, Kwon, B. J., additional, Kim, D. B., additional, Jang, S. W., additional, Cho, J. S., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, J. H., additional, Cikes, M., additional, Bijnens, B., additional, Velagic, V., additional, Kopjar, T., additional, Milicic, D., additional, Biocina, B., additional, Gasparovic, H., additional, Almuntaser, I., additional, Brown, A., additional, Foley, B., additional, Mulvihill, N., additional, Crean, P., additional, King, G., additional, Murphy, R., additional, Takata, Y., additional, Taniguchi, M., additional, Nobusada, S., additional, Sugawara, M., additional, Toh, N., additional, Kusano, K., additional, Itoh, H., additional, Wellnhofer, E., additional, Kriatselis, C., additional, Nedios, S., additional, Gerds-Li, J. H., additional, Fleck, E., additional, Poulsen, M. K., additional, Henriksen, J. E., additional, Dahl, J., additional, Johansen, A., additional, Haghfelt, T., additional, Hoilund-Carlsen, P. F., additional, Beck-Nielsen, H., additional, Moller, J. E., additional, Dankowski, R., additional, Wierzchowiecki, M., additional, Michalski, M., additional, Nowicka, A., additional, Szymanowska, K., additional, Pajak, A., additional, Poprawski, K., additional, Szyszka, A., additional, Kasner, M., additional, Westermann, D., additional, Schultheiss, H. P., additional, Tschoepe, C., additional, Watanabe, T., additional, Iwai-Takano, M., additional, Kobayashi, A., additional, Machii, H., additional, Takeishi, Y., additional, Paelinck, B. P., additional, Van Herck, P. L., additional, Bosmans, J. M., additional, Vrints, C. J., additional, Lamb, H. J., additional, Doltra, A., additional, Vidal, B., additional, Silva, E., additional, Poyatos, S., additional, Mont, L., additional, Berruezo, A., additional, Castel, A., additional, Tolosana, J. M., additional, Brugada, J., additional, Sitges, M., additional, Dencker, M., additional, Bjorgell, O., additional, Hlebowicz, J., additional, Szelenyi, Z. S., additional, Szenasi, G., additional, Kiss, M., additional, Prohaszka, Z., additional, Patocs, A., additional, Karadi, I., additional, Vereckei, A., additional, Saha, S. K., additional, Anderson, P. L., additional, Govind, S., additional, Govindan, M., additional, Moggridge, J. C., additional, Kiotsekoglou, A., additional, Gopal, A. S., additional, Loegstrup, B. B., additional, Christophersen, T. B., additional, Hoefsten, D. E., additional, Moeller, J. E., additional, Boetker, H. E., additional, Egstrup, K., additional, Graefe, M., additional, Huang, F. Q., additional, Zhang, R. S., additional, Le, T. T., additional, Tan, R. S., additional, Sattarzadeh Badkoubeh, R., additional, Tavoosi, A., additional, Elahian, A. R., additional, Drapkina, O., additional, Ivashkin, V. I., additional, Fazakas, A., additional, Pepo, L., additional, Janosi, O., additional, Kopitovic, I., additional, Goncalves, A., additional, Marcos-Alberca, P., additional, Almeria, C., additional, Feltes, G., additional, Rodriguez, E., additional, Garcia, E., additional, Hernandez-Antolin, R., additional, Macaya, C., additional, Silva Cardoso, J., additional, Zamorano, J. L., additional, Navarro, M. S., additional, Valentin, M., additional, Banes, C. M., additional, Rigo, F., additional, Grolla, E., additional, Tona, F., additional, Cuaia, V., additional, Moreo, A., additional, Badano, L., additional, Raviele, A., additional, Iliceto, S., additional, Tarzia, P., additional, Sestito, A., additional, Nerla, R., additional, Di Monaco, A., additional, Infusino, F., additional, Matera, D., additional, Greco, F., additional, Tacchino, R. M., additional, Lanza, G. A., additional, Crea, F., additional, Nemes, A., additional, Balazs, E., additional, Pinter, K. S., additional, Egyed, A., additional, Csanady, M., additional, Forster, T., additional, Holte, E., additional, Vegsundvag, J., additional, Hole, T., additional, Hegbom, K., additional, Wiseth, R., additional, Sharif, D., additional, Sharif-Rasslan, A., additional, Shahla, C., additional, Khalil, A., additional, Rosenschein, U., additional, Zagatina, A., additional, Zhuravskaya, N., additional, Tyurina, T. V., additional, Tagliamonte, E., additional, Cirillo, T., additional, Coppola, A., additional, Marinelli, U., additional, Romano, C., additional, Riccio, G., additional, Citro, R., additional, Astarita, C., additional, Capuano, N., additional, Quaranta, G., additional, Desiderio, A., additional, Frattini, S., additional, Faggiano, P., additional, Zilioli, V., additional, Locantore, E., additional, Longhi, S., additional, Bellandi, F., additional, Faden, G., additional, Triggiani, M., additional, Dei Cas, L., additional, Dalsgaard, M., additional, Kjaergaard, J., additional, Iversen, K., additional, Hassager, C., additional, Dinh, W., additional, Nickl, W. N., additional, Smettan, J. S., additional, Koehler, T. K., additional, Scheffold, T. D., additional, Coll Barroso, M. C. B., additional, Guelker, J. G., additional, Fueth, R. F., additional, Kamperidis, V., additional, Hadjimiltiades, S., additional, Sianos, G., additional, Efthimiadis, G., additional, Karvounis, H., additional, Parcharidis, G., additional, Styliadis, I. H., additional, Velasco Del Castillo, M. S., additional, Onaindia, J. J., additional, Telleria, M., additional, Carstensen, H. G., additional, Nordenberg, C., additional, Sogaard, P., additional, Fritz-Hansen, T., additional, Bech, J., additional, Galatius, S., additional, Jensen, J. S., additional, Mogelvang, R., additional, Bartko, P. E., additional, Graf, S., additional, Rosenhek, R., additional, Burwash, I. G., additional, Bergler-Klein, J., additional, Clavel, M.-A., additional, Baumgartner, H., additional, Pibarot, P., additional, Mundigler, G., additional, Kirilmaz, B., additional, Eser, I., additional, Tuzun, N., additional, Komur, B., additional, Dogan, H., additional, Taskiran Comez, A., additional, Ercan, E., additional, Cusma-Piccione, M., additional, Zito, C., additional, Oreto, G., additional, Piluso, S., additional, Tripepi, S., additional, Oreto, L., additional, Longordo, C., additional, Ciraci, L., additional, Di Bella, G., additional, Piatkowski, R., additional, Kochanowski, J., additional, Scislo, P., additional, Grabowski, M., additional, Marchel, M., additional, Roik, M., additional, Kosior, D., additional, Opolski, G., additional, Sknouril, L., additional, Dorda, M., additional, Holek, B., additional, Gajdusek, L., additional, Chovancik, J., additional, Branny, M., additional, Fiala, M., additional, Szymanski, P., additional, Lipczynska, M., additional, Klisiewicz, A., additional, Hoffman, P., additional, Jander, N., additional, Minners, J., additional, Martin, G., additional, Zeh, W., additional, Allgeier, M., additional, Gohlke-Baewolf, C., additional, Gohlke, H., additional, Nistri, S., additional, Porciani, M. C., additional, Attanasio, M., additional, Abbate, R., additional, Gensini, G. F., additional, Pepe, G., additional, Duncan, R. F., additional, Piantadosi, C., additional, Nelson, A. J., additional, Wittert, G., additional, Dundon, B., additional, Worthley, M. I., additional, Worthley, S. G., additional, Jung, P., additional, Berlinger, K., additional, Rieber, J., additional, Sohn, H. Z., additional, Schneider, P., additional, Leibig, M., additional, Koenig, A., additional, Klauss, V., additional, Tomkiewicz-Pajak, L., additional, Kolcz, J., additional, Olszowska, M., additional, Pieculewicz, M., additional, Podolec, P., additional, Przewlocki, T., additional, Suchon, E., additional, Sobien, B., additional, Wilkolek, P., additional, Ziembicka, A., additional, Hlawaty, M., additional, Van De Bruaene, A., additional, Hermans, H., additional, Buys, R., additional, Vanhees, L., additional, Delcroix, M., additional, Voigt, J.-U., additional, Budts, W., additional, De Cillis, E., additional, Acquaviva, T., additional, Basile, D., additional, Bortone, A. S., additional, Kalimanovska-Ostric, D., additional, Nastasovic, T., additional, Vujisic-Tesic, B., additional, Jovanovic, I., additional, Milakovic, B., additional, Dostanic, M., additional, Stosic, M., additional, Frogoudaki, A., additional, Andreou, K., additional, Parisis, J., additional, Triantafyllidi, E., additional, Gaitani, S., additional, Paraskevaidis, J., additional, Anastasiou-Nana, M., additional, De Pasquale, G., additional, Kuehn, A., additional, Petzuch, K., additional, Mueller, J., additional, Meierhofer, C., additional, Fratz, S., additional, Hager, A., additional, Hess, J., additional, Vogt, M., additional, Attenhofer Jost, C. H., additional, Dearani, J. A., additional, Scott, C. G., additional, Burkhart, H. M., additional, Connolly, H. M., additional, Vitarelli, A., additional, Battaglia, D., additional, Caranci, F., additional, Padella, V., additional, Continanza, G., additional, Dettori, O., additional, Capotosto, L., additional, Vitarelli, M., additional, De Cicco, V., additional, Cortez Morichetti, M., additional, Mohanan Nair, K. K., additional, Sasidaharan, B., additional, Thajudeen, A., additional, Tharakan, J. M., additional, Mertens, L., additional, Ahmad, N., additional, Kantor, P. K., additional, Grosse-Wortmann, L., additional, Friedberg, M. K., additional, Bernard, Y. F., additional, Morel, M. A., additional, Descotes-Genon, V., additional, Jehl, J., additional, Meneveau, N., additional, Schiele, F., additional, Kaldararova, M., additional, Simkova, I., additional, Tittel, P., additional, Masura, J., additional, Trojnarska, O., additional, Szczepaniak, L., additional, Mizia -Stec, K., additional, Cieplucha, A., additional, Bartczak, A., additional, Grajek, S., additional, Tykarski, A., additional, Gasior, Z., additional, Babovicvuksanovic, D., additional, Bonnichsen, C. R., additional, Morgan, G. J., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Lee, K. J., additional, Chaturvedi, R., additional, Benson, L., additional, Bradley, T., additional, Iancu, M. E., additional, Ghiorghiu, I., additional, Serban, M., additional, Craciunescu, I., additional, Hodo, A., additional, Morgan, J., additional, Roche, L., additional, Lee, K., additional, Milanesi, O., additional, Favero, V., additional, Padalino, M., additional, Biffanti, R., additional, Cerutti, A., additional, Maschietto, N., additional, Reffo, E., additional, Vida, V., additional, Stellin, G., additional, Irtyuga, O., additional, Gamazin, D., additional, Voronkina, I., additional, Tsoyi, N., additional, Gudkova, E., additional, Moiseeva, O., additional, Aggeli, C., additional, Kazazaki, C., additional, Felekos, I., additional, Lagoudakou, S., additional, Roussakis, G., additional, Skoumas, J., additional, Pitsavos, C., additional, Stefanadis, C., additional, Cueff, C., additional, Keenan, N., additional, Steg, P. G., additional, Cimadevilla, C., additional, Ducrocq, G., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Petrella, L., additional, Mazzola, A. M., additional, Villani, C. V., additional, Giancola, R. G., additional, Ciocca, M. C., additional, Di Eusanio, D. E. M., additional, Nolan, S., additional, Ionescu, A., additional, Skaug, T. R., additional, Amundsen, B. H., additional, Hergum, T., additional, Torp, H., additional, Haugen, B. O., additional, Lopez Aguilera, J., additional, Mesa Rubio, D., additional, Ruiz Ortiz, M., additional, Delgado Ortega, M., additional, Villanueva Fernandez, E., additional, Cejudo Diaz Del Campo, L., additional, Toledano Delgado, F., additional, Leon Del Pino, M., additional, Romo Pena, E., additional, Suarez De Lezo Cruz-Conde, J., additional, De Marco, E., additional, Colucci, A., additional, Comerci, G., additional, Gabrielli, F. A., additional, Natali, R., additional, Garramone, B., additional, Savino, M., additional, Lotrionte, M., additional, Sonaglioni, A., additional, Loperfido, F., additional, Zdravkovic, M., additional, Perunicic, J., additional, Krotin, M., additional, Ristic, M., additional, Vukomanovic, V., additional, Zaja, M., additional, Radovanovic, S., additional, Saric, J., additional, Zdravkovic, D., additional, Cotrim, C., additional, Almeida, A. R., additional, Miranda, R., additional, Almeida, A. G., additional, Picano, E., additional, Carrageta, M., additional, D'andrea, A., additional, Cocchia, R., additional, Riegler, L., additional, Golia, E., additional, Scarafile, R., additional, Caso, P., additional, Russo, M. G., additional, Bossone, E., additional, Calabro', R., additional, Noman, H., additional, Adel, A., additional, Elfaramawy, A. M. R., additional, Abdelraouf, M., additional, Elnaggar, W. A. E. L., additional, Baligh, E., additional, Sargento, L., additional, Silva, D., additional, Goncalves, S., additional, Ribeiro, S., additional, Vinhas Sousa, G., additional, Almeida, A., additional, Lopes, M., additional, Rodriguez-Manero, M., additional, Aguado Gil, L., additional, Azcarate, P., additional, Lloret Luna, P., additional, Macias Gallego, A., additional, Castano, S. A. R. A., additional, Garcia, M., additional, Pujol Salvador, C., additional, Barba, J., additional, Redondo, P., additional, Tomasoni, L., additional, Sitia, S., additional, Atzeni, F., additional, Gianturco, L., additional, Ricci, C., additional, Sarzi-Puttini, P., additional, Turiel, M., additional, De Gennaro Colonna, V., additional, Uejima, T., additional, Jaroch, J., additional, Polombo, C., additional, Hughes, A., additional, Vinereanu, D., additional, Evanvelista, A., additional, Leftheriotis, G., additional, Fraser, A. G., additional, Lewczuk, A., additional, Sobkowicz, B., additional, Tomaszuk-Kazberuk, A., additional, Sawicki, R., additional, Hirnle, T., additional, Michalski, B. W., additional, Filipiak, D., additional, Kasprzak, J. D., additional, Lipiec, P., additional, Dalen, H., additional, Mjolstad, O. C., additional, Klykken, B. E., additional, Graven, T., additional, Martensson, M., additional, Olsson, M., additional, Brodin, L.-A., additional, Enache, R., additional, Leiballi, E., additional, Penhall, A., additional, Perry, R., additional, Altman, M., additional, Sinhal, A., additional, Bennetts, J., additional, Chew, D. P., additional, Joseph, M. X., additional, Larsen, L. H., additional, Kristensen, T., additional, Kober, L. V., additional, Kofoed, K. F., additional, Moscoso Costa, F., additional, Ribeiras, R., additional, Brito, J., additional, Boshoff, S., additional, Neves, J., additional, Teles, R., additional, Canada, M., additional, Andrade, M. J., additional, Gouveia, R., additional, Silva, A., additional, Miskovic, A., additional, Poerner, T. P., additional, Stiller, C. S., additional, Goebel, B. G., additional, Moritz, A. M., additional, Stefani, L., additional, Galanti, G. G., additional, Moraldo, M., additional, Bergamini, C., additional, Pabari, P. A., additional, Dhutia, N. M., additional, Malaweera, A. S. N., additional, Willson, K., additional, Davies, J., additional, Hughes, A. D., additional, Xu, X. Y., additional, Francis, D. P., additional, Jasaityte, R., additional, Amundsen, B., additional, Barbosa, D., additional, Loeckx, D., additional, Kiss, G., additional, Orderud, F., additional, Robesyn, V., additional, Claus, P., additional, D'hooge, J., additional, Nao, T., additional, Miura, T., additional, Shams, K., additional, Samir, S., additional, Samir, R., additional, El-Sayed, M., additional, Anwar, A. M., additional, Nosir, Y., additional, Galal, A., additional, Chamsi-Pasha, H., additional, Ciobanu, A., additional, Dulgheru, R., additional, Bennett, S., additional, De Luca, A., additional, Toncelli, L., additional, Cappelli, F., additional, Cappelli, B., additional, Vono, M. C. R., additional, Galanti, G., additional, Zorman, Y., additional, Yilmazer, M. S., additional, Akyildiz, M., additional, Gurol, T., additional, Aydin, A., additional, Dagdeviren, B., additional, and Kalangos, A., additional

Published
2010
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222. A thermal-neutron detector with a phoswich system of LiCaAlF6 and BGO crystal scintillators onboard PoGOLite

Author

Takahashi, H, primary, Yonetani, M, additional, Matsuoka, M, additional, Mizuno, T, additional, Fukazawa, Y, additional, Yanagida, T, additional, Fujimoto, Y, additional, Yokota, Y, additional, Yoshikawa, A, additional, Kawaguchi, N, additional, Ishizu, S, additional, Fukuda, K, additional, Suyama, T, additional, Watanabe, K, additional, Tajima, H, additional, Kanai, Y, additional, Kawai, N, additional, Kataoka, J, additional, Katsuta, J, additional, Takahashi, T, additional, Gunji, S, additional, Axelsson, M, additional, Jackson, M, additional, Kiss, M, additional, Klamra, W, additional, Kole, M, additional, Larsson, S, additional, Mallol, P, additional, Pearce, M, additional, Ryde, F, additional, Rydstrom, S, additional, Olofsson, G, additional, Floren, H, additional, Kamae, T, additional, Madejski, G, additional, and Varner, G, additional

Published
2010
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227. PoGOLite: A balloon-borne soft gamma-ray polarimeter

Author

Jackson, M., primary, Pearce, M., additional, Takahashi, H., additional, Axelsson, M., additional, Floren, H-G., additional, Fukazawa, Y., additional, Gunji, S., additional, Kamae, T., additional, Kanai, Y., additional, Kataoka, J., additional, Kawai, N., additional, Kiss, M., additional, Klamra, W., additional, Larsson, S., additional, Madejski, G., additional, Maeda, K., additional, Mallol, P., additional, Bettolo, C. Marini, additional, Miyamoto, Y., additional, Mizuno, T., additional, Olofsson, G., additional, Ryde, F., additional, Rydstrom, S., additional, Stromberg, J-E., additional, Tajima, H., additional, Takahashi, T., additional, Tanaka, T., additional, Thurston, T., additional, Varner, G., additional, and Yoshida, H., additional

Published
2009
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233. A Monte Carlo method for calculating the energy response of plastic scintillators to polarized photons below 100keV

Author

Mizuno, T., primary, Kanai, Y., additional, Kataoka, J., additional, Kiss, M., additional, Kurita, K., additional, Pearce, M., additional, Tajima, H., additional, Takahashi, H., additional, Tanaka, T., additional, Ueno, M., additional, Umeki, Y., additional, Yoshida, H., additional, Arimoto, M., additional, Axelsson, M., additional, Marini Bettolo, C., additional, Bogaert, G., additional, Chen, P., additional, Craig, W., additional, Fukazawa, Y., additional, Gunji, S., additional, Kamae, T., additional, Katsuta, J., additional, Kawai, N., additional, Kishimoto, S., additional, Klamra, W., additional, Larsson, S., additional, Madejski, G., additional, Ng, J.S.T., additional, Ryde, F., additional, Rydström, S., additional, Takahashi, T., additional, Thurston, T.S., additional, and Varner, G., additional

Published
2009
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235. Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT.

Author

Farkas, A, Kemény, L, Szöny, B J, Bata-Csörgö, Z, Pivarcsi, A, Kiss, M, Széll, M, Koreck, A, Dobozy, A, Farkas, A, Kemény, L, Szöny, B J, Bata-Csörgö, Z, Pivarcsi, A, Kiss, M, Széll, M, Koreck, A, and Dobozy, A

Abstract

OBJECTIVE: Dithranol is highly effective in the treatment of psoriasis, however its mode of action is still not well known. Since interleukin-8 and interleukin-10 are involved in the pathogenesis of psoriasis, the aim of our study was to investigate the effect of dithranol on interleukin-8, interleukin-10 mRNA production and interleukin-10 receptor expression of the HaCaT keratinocyte cell line which is commonly used in experiments examining the effects of therapeutic drugs on keratinocytes. MATERIALS AND METHODS: Cultured HaCaT cells were treated with 0.1-0.5 microg/ml dithranol for 30 minutes. After 2 and 4 h total cellular RNA isolated from HaCaT cells was reverse transcribed (RT) to cDNA which was subjected to polymerase chain reaction (PCR) with specific primer pairs for interleukin-8, interleukin-10 and interleukin-10 receptor. For immunohistochemistry cultured HaCaT cells were stained with a monoclonal antibody against the human interleukin-10 receptor. RESULTS: Our results showed that dithranol treatment did not change the highly elevated level of interleukin-8 mRNA of HaCaT cells. Interleukin-10 mRNA signal with RT-PCR could not be detected in HaCaT cells. Depending on the concentration dithranol increased the mRNA production of interleukin-10 receptors in HaCaT cells. This dithranol induced dose dependent upregulation of IL-10 receptors in HaCaT cells was also observed on the protein level using immunohistochemistry. CONCLUSIONS: Since the interleukin-10 receptor expression of keratinocytes in psoriatic lesional skin is downregulated, the dithranol induced upregulation of the receptor in our model system might help to reveal the therapeutic action of the drug.

Published
2001
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236. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans.

Author

Szolnoky, G, Bata-Csörgö, Z, Kenderessy, A S, Kiss, M, Pivarcsi, A, Novák, Z, Nagy Newman, K, Michel, G, Ruzicka, T, Maródi, L, Dobozy, A, Kemény, L, Szolnoky, G, Bata-Csörgö, Z, Kenderessy, A S, Kiss, M, Pivarcsi, A, Novák, Z, Nagy Newman, K, Michel, G, Ruzicka, T, Maródi, L, Dobozy, A, and Kemény, L

Abstract

Human keratinocytes are known to kill Candida albicans in vitro, but the mechanism of killing is not yet understood. Here, we demonstrate that spontaneous, ultraviolet-B-light-induced, alpha-melanocyte-stimulating-hormone-induced, and interleukin-8-induced Candida killing by keratinocytes can be inhibited with mannan and mannosylated bovine serum albumin (Man-BSA). A polyclonal goat serum raised against the human macrophage mannose receptor stained suprabasal keratinocytes, but no staining was observed on keratinocytes with a monoclonal antibody (mAb15) specific for the human macrophage mannose receptor. Mannose-affinity chromatography of keratinocyte extract isolated a 200 kDa protein, and on the Western blot the goat antiserum reacted with a 200 kDa protein. In radioligand binding studies, the binding of 125I-Man-BSA to human keratinocytes was inhibited by mannan in a concentration-dependent manner. Analysis of the binding revealed a single class keratinocyte mannose receptor with a KD of 1.4 x 10(-8) M and a Bmax of 1 x 10(4) binding sites per cell. The binding of 125I-Man- BSA to keratinocytes proved to be time-dependent, acid-precipitable, and Ca2+- and trypsin-sensitive. After trypsinization the receptors underwent a rapid recovery at 37 degrees C. These results demonstrate the presence of mannose receptor on human keratinocytes, and its active involvement in the killing of Candida albicans.

Published
2001
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237. Beam test results of the polarized gamma-ray observer, PoGOLite

Author

Takahashi, H., primary, Matsuoka, M., additional, Umeki, Y., additional, Yoshida, H., additional, Tanaka, T., additional, Mizuno, T., additional, Fukazawa, Y., additional, Kamae, T., additional, Madejski, G., additional, Tajima, H., additional, Kiss, M., additional, Klamra, W., additional, Larsson, S., additional, Marini Bettolo, C., additional, Pearce, M., additional, Ryde, F., additional, Rydstrom, S., additional, Kurita, K., additional, Kanai, Y., additional, Arimoto, M., additional, Ueno, M., additional, Kataoka, J., additional, Kawai, N., additional, Axelsson, M., additional, Hjalmarsdotter, L., additional, Bogaert, G., additional, Gunji, S., additional, Takahashi, T., additional, Varner, G., additional, and Yuasa, T., additional

Published
2008
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238. The PoGOLite balloon-borne soft gamma-ray polarimeter

Author

Kiss, M., primary, Larsson, S., additional, Arimoto, M., additional, Axelsson, M., additional, Bettolo, C. Marini, additional, Bogaert, G., additional, Florén, H.-G., additional, Fukazawa, Y., additional, Gunji, S., additional, Hjalmarsdotter, L., additional, Kamae, T., additional, Kanai, Y., additional, Kataoka, J., additional, Kawai, N., additional, Klamra, W., additional, Kurita, K., additional, Madejski, G., additional, Mizuno, T., additional, Olofsson, G., additional, Pearce, M., additional, Ryde, F., additional, Rydström, S., additional, Tajima, H., additional, Takahashi, H., additional, Takahashi, T., additional, Tanaka, T., additional, Ueno, M., additional, Umeki, Y., additional, Varner, G., additional, Yoshida, H., additional, and Axelsson, Magnus, additional

Published
2008
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239. Performance assessment study of the balloon-borne astronomical soft gamma-ray polarimeter PoGOLite

Author

Arimoto, M., primary, Kanai, Y., additional, Ueno, M., additional, Kataoka, J., additional, Kawai, N., additional, Tanaka, T., additional, Yamamoto, K., additional, Takahashi, H., additional, Mizuno, T., additional, Fukazawa, Y., additional, Axelsson, M., additional, Kiss, M., additional, Marini Bettolo, C., additional, Carlson, P., additional, Klamra, W., additional, Pearce, M., additional, Chen, P., additional, Craig, B., additional, Kamae, T., additional, Madejski, G., additional, Ng, J.S.T., additional, Rogers, R., additional, Tajima, H., additional, Thurston, T.S., additional, Saito, Y., additional, Takahashi, T., additional, Gunji, S., additional, Bjornsson, C.-I., additional, Larsson, S., additional, Ryde, F., additional, Bogaert, G., additional, and Varner, G., additional

Published
2007
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240. Measuring energy dependent polarization in soft γ-rays using Compton scattering in PoGOLite

Author

Axelsson, M., primary, Engdegård, O., additional, Ryde, F., additional, Larsson, S., additional, Pearce, M., additional, Hjalmarsdotter, L., additional, Kiss, M., additional, Bettolo, C. Marini, additional, Arimoto, M., additional, Björnsson, C.-I., additional, Carlson, P., additional, Fukazawa, Y., additional, Kamae, T., additional, Kanai, Y., additional, Kataoka, J., additional, Kawai, N., additional, Klamra, W., additional, Madejski, G., additional, Mizuno, T., additional, Ng, J., additional, Tajima, H., additional, Takahashi, T., additional, Tanaka, T., additional, Ueno, M., additional, Varner, G., additional, and Yamamoto, K., additional

Published
2007
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242. Data acquisition system for the PoGOLite astronomical hard X-ray polarimeter

Author

Tanaka, T., primary, Arimoto, M., additional, Axelsson, M., additional, Bjornsson, C.-I., additional, Bogaert, G., additional, Carlson, P., additional, Cooney, M., additional, Craig, W., additional, Engdegard, O., additional, Fukazawa, Y., additional, Gunji, S., additional, Hjalmarsdotter, L., additional, Kamae, T., additional, Kanai, Y., additional, Kataoka, J., additional, Katsuta, J., additional, Kawai, N., additional, Kazejev, J., additional, Kiss, M., additional, Klamra, W., additional, Larsson, S., additional, Madejski, G., additional, Marini Bettolo, C., additional, Mizuno, T., additional, Ng, J., additional, Nomachi, M., additional, Odaka, H., additional, Pearce, M., additional, Ruckman, L., additional, Ryde, F., additional, Tajima, H., additional, Takahashi, H., additional, Takahashi, T., additional, Thurston, T., additional, Ueno, M., additional, Varner, G., additional, Ylinen, T., additional, Yoshida, H., additional, and Yuasa, T., additional

Published
2007
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243. High sensitivity balloon-borne hard X-ray/soft Gamma-Ray Polarimeter PoGOLite

Author

Mizuno, T., primary, Arimoto, M., additional, Axelsson, M., additional, Bjornsson, C. -I., additional, Bogaert, G., additional, Carlson, P., additional, Craig, W., additional, Fukazawa, Y., additional, Gunji, S., additional, Hjalmarsdotter, L., additional, Kamae, T., additional, Kanai, Y., additional, Kataoka, J., additional, Katsuta, J., additional, Kawai, N., additional, Kiss, M., additional, Klamra, W., additional, Larsson, S., additional, Madejski, G., additional, Marini Bettolo, C., additional, Ng, J., additional, Pearce, M., additional, Ryde, F., additional, Tajima, H., additional, Takahashi, H., additional, Takahashi, T., additional, Tanaka, T., additional, Thurston, T., additional, Ueno, M., additional, Varner, G., additional, and Yoshida, H., additional

Published
2007
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244. Beam test of a prototype phoswich detector assembly for the PoGOLite astronomical soft gamma-ray polarimeter

Author

Kanai, Y., primary, Ueno, M., additional, Kataoka, J., additional, Arimoto, M., additional, Kawai, N., additional, Yamamoto, K., additional, Mizuno, T., additional, Fukazawa, Y., additional, Kiss, M., additional, Ylinen, T., additional, Marini Bettolo, C., additional, Carlson, P., additional, Klamra, W., additional, Pearce, M., additional, Chen, P., additional, Craig, B., additional, Kamae, T., additional, Madejski, G., additional, Ng, J.S.T., additional, Rogers, R., additional, Tajima, H., additional, Thurston, T.S., additional, Saito, Y., additional, Takahashi, T., additional, Gunji, S., additional, Bjornsson, C.-I., additional, Larsson, S., additional, Ryde, F., additional, Bogaert, G., additional, and Kishimoto, S., additional

Published
2007
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