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In this article, special type of RF Charger is proposed for Wireless RF power harvesting system. RF charger is consisted of impedance matching circuit, full bridge CMOS rectifier, active diode, hysteresis switch, and DC–DC booster. The proposed RF charger is to obtain maximum available RF power through adjusting impedance matching circuitries. The proposed RF charger is matched to Korean WCDMA frequency band from 1960 to 1980 MHz. The minimum input RF power for charging 5 V battery is −10 dBm. The RF to DC conversion efficiency of the RF charger is 81% at 30 mA load current with 5 V battery, and the maximum output voltage is 5.5 V. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1622–1625, 2015

PURPOSES : The key point of a multimodal LOS (level-of-service) evaluation system is that all of the modes are mutually associated to determine each mode`s LOS. For example, the LOS of the bicycle mode is measured based on not only bicycle volumes, but also automobile volumes. However, the Korea Highway Capacity Manual (KHCM) still focuses on the automobile mode in evaluating the LOS of the roads. Additionally, the KHCM`s LOS of the other modes, except for the automobile, is not consistent with actual road conditions. The KHCM, therefore, needs to develop and introduce a multimodal LOS system in order to evaluate the service conditions more accurately. METHODS: As a preliminary step to the introduction of multimodal LOS research, in this study the current problem of the KHCM`s LOS system through a close review and comparison with other HCMs (highway capacity manuals) was identified. Secondly, a field survey and investigation of the urban streets to apply the HCM`s multimodal LOS system was conducted. Finally, a comparison analysis of the results of the HCM and KHCM LOS was performed. RESULTS: In the study, it was found that the results of the LOS for the automobile mode did not show a significant difference between the HCM and KHCM. However, the LOS of the bicycle and pedestrian mode tended to be worse in the multimodal LOS system, which results from considering the effects of the automobile mode. Moreover, it was found that many cases have the potential to improve the overall LOS conditions, while reducing the automobile capacity. CONCLUSIONS: With the introduction of the multimodal LOS system, road diet and complete streets can be easily applied to ans actual road improvement project. Ultimately, the multimodal LOS system should be introduced into the KHCM, which can then be applied to traffic impact studies and other road improvement projects for more accurate evaluations.

Introduction In the seventh TNM classification, stage IIIA includes tumors with early stage of bowel wall invasion and regional lymph node metastasis. We investigated the validity of the current TNM classification of patients with stage IIIA colorectal cancer and identified prognostic factors of them for ameliorating treatment strategies for them. Methods This study included the participation of four tertiary hospitals. A total of 4,236 patients with Stages I–IIIB colorectal cancer were analyzed. The primary end point was the 5-year relapse-free survival. Results The 5-year relapse-free survival of patients with stage IIIA disease was similar to that of patients with stage IIA. The 5-year relapse-free survival was 88.9% in the chemotherapy group (n = 152) and 82.3% in the no-chemotherapy group (n = 36, P = 0.111). Tumor differentiation (moderate or poor) and venous invasion were independent prognostic factors of relapse-free survival. Conclusions The relapse-free survival of patients with stage IIIA tumors was similar to that of patients with stage IIA tumors, and the prognosis of stage IIIA tumors varied significantly by the tumor factors identified. These factors can be used to predict the risk of disease recurrence and to optimize the use of adjuvant chemotherapy. J. Surg. Oncol. 2015 111:882–890. © 2014 Wiley Periodicals, Inc.

This article presents an adaptive tuning technique for improving the power flatness of an X-band frequency multiplier. The major features are highlighted: a tunable band-pass filter, and a microcontroller process. Simulation and measurement results show the power flatness is improved from 5–5.5 dB to 0.5–1 dB. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1056–1060, 2015

Spatial thermal distribution of a chip is an essential information for dynamic thermal management. To get a rich thermal map, the sensor area is required to be reduced radically. However, squeezing the sensor size is about to face its physical limitation. In this background, we propose an area-efficient thermal sensing technique: hybrid temperature sensor network. The proposed sensor architecture fully exploits the spatial low-pass filtering effect of thermal systems, which implies that most of the thermal information resides in very low spatial frequency region. Our on-chip sensor network consists of a small number of accurate thermal sensors and a large number of tiny relative thermal sensors, responsible for low and high spatial frequency thermal information respectively. By combining these sensor readouts, a thermal map upsampler synthesizes a higher spatial resolution thermal map with a proposed guided upsampling algorithm.

Bong-Kyun Kim Jun-Seok Park Dae-Seuk Seo Wha-Jung Kim Yun-Yung KimAbstractIn recent years, a rapid growth in the population and urbanization led to an increasing industrial growth. The inadequate treated-wasted water from industry and various non-point sources causes significant negative effects on the stream water. For past few decades, extensive researches have been performed on water purification process. The purpose of this study is to investigate mechanical performance and water purification properties of porous concrete by using effective microorganisms through the site assessment test. The mechanical performance evaluation results showed that the increase void ration caused an decrease in the strength. The optimal mix rate was found to be 15% void rate From the site assessment, it was evaluated that the porous concrete improved the quality of the water and the purification ratios are 34.1 for SS, 14.6% for BOD, 34.9% for COD, 11.4% for T-N,and 12.6% for T-P. The porous concrete and the related purification technique can reduce the non-point pollution sources flowing into the river.Keywords : Effective micro-organisms, Porous concrete, Water purification, Site assessment test

Objectives: The clinical significance of aquaporin-1 (AQP1), aquaporin-3 (AQP3), and aquaporin-5 (AQP5) expression was analyzed in a large number of patients with colon cancer. Methods: AQP1, AQP3, and AQP5 expression was investigated based on the immunohistochemistry of tissue microarray specimens from 486 colon cancer patients who underwent curative surgery. Scores were given to the staining intensity and percentage of positive cells, and the staining score was defined as the sum of these scores then used to categorize the AQP expression as negative, weakly AQP-positive, or strongly AQP-positive. Results: A total of 298 (61.3%) patients were identified as strongly AQP1-positive (staining score ≥6), while 38 (7.8%) were strongly AQP3-positive and 145 (29.8%) were strongly AQP5-positive. The overexpression of AQP1, AQP3, and AQP5 was significantly correlated with lymph node metastasis in a multivariate logistic analysis (AQP1, p = 0.026; AQP3, p = 0.023; AQP5, p = 0.003). While the multivariate survival analysis, which included age, histology, TNM stage, and CEA level showed that the expression of AQP1, AQP3, and AQP5 had no effect on the overall survival and disease-free survival. Conclusions: The current study found a significant correlation between AQP1, AQP3, and AQP5 expression and lymph node metastasis in patients with surgically resected colon cancer.

Nerve-preserving surgery has been provided for patients with rectal cancer; however, sexual dysfunction remains a common complication of rectal cancer surgery. This study explored the efficacy of udenafil to treat erectile dysfunction in male patients who underwent total mesorectal excision (TME) for rectal cancer.We conducted a randomized, double-blind, placebo-controlled clinical trial involving 80 male patients who had decreased International Index of Erectile Function-5 (IIEF-5) scores after TME for rectal cancer. Patients received placebo (50 mg) or udenafil (50 mg) for 12 weeks. The primary outcome variable was the change in IIEF-5 scores. The secondary outcome variables were Sexual Encounter Profile (SEP) questions 2 (Q2) and 3 (Q3), and the Global Assessment Question (GAQ).Baseline IIEF-5 scores, SEP Q2 and Q3 responses, and spontaneous erection rates were consistent in both groups. At the end of treatment, the change in IIEF-5 scores from the baseline was significantly higher in the udenafil group than it was in the placebo group (mean IIEF-5 score, 4.8 ± 4.0 vs 2.0 ± 1.7; P.05). Responses to SEP Q2, SEP Q3, and GAQ were significantly higher in the udenafil group than they were in the placebo group (SEP Q2, P = .025; SEP Q3, P = .044; GAQ, P.001). Treatment-related adverse events (n = 4) were all mild in severity.Oral udenafil was deemed safe and effective for the treatment of erectile dysfunction in patients who underwent TME for rectal cancer.

This study aimed to evaluate the efficacy of post-operative oral nutrition supplementation after major gastrointestinal surgery.A prospective randomized controlled trial was conducted to evaluate 174 subjects who were discharged within 2 weeks after major gastrointestinal surgery. The subjects in the study group were prescribed 400 ml/day of Encover® from the day of discharge for 8 weeks, but no supplementation was allowed in the control group. The primary endpoint was the weight loss rate at 8 weeks after discharge compared with the pre-operative weight, and the secondary endpoints included changes in body weight, body mass index, Patient-Generated Subjective Global Assessment score/grade, hematological/ biochemical parameters, and adverse events evaluated at 2, 4, and 8 weeks after discharge.The weight loss rate at 8 weeks after discharge did not differ between two groups (4.23±5.49% vs 4.80±4.84%, p=0.481). The total lymphocyte count, the level of total cholesterol, total protein, and albumin were significantly higher in the study group after discharge. Diarrhea was the most frequent adverse event, and the incidence of adverse events with a severity score of=3 did not differ between groups (2.3% vs 1.2%).The utility of routine oral nutritional support after major gastrointestinal surgery was not proven in terms of weight loss at 8 weeks after discharge. However, it can be beneficial for early recovery of biochemical parameters.

OBJECTIVE We aimed to investigate the factors related to satisfaction with the pediatric emergency department service in Korea. METHODS This study examined data from the Korea Health Panel Data from 2010 to 2012. Pediatric patients who visited the emergency department at least once between 2010 and 2012 in Korea were included. Data were collected on patient satisfaction with the emergency department service, and factors related to the patient characteristics, emergency department service process, and medical institution. We compared the dissatisfied and satisfied groups, and calculated the odds ratios for satisfaction according to each variable. RESULTS A total of 1,505 emergency department visits from 947 pediatric patients during the 3-year period were analyzed. We estimated that about 79.5% of patients in the population were satisfied. The odds of expressing satisfaction were higher among males than in females, and among patients who were hospitalized after emergency department treatment compared to those who were transferred to another hospital. Conversely, the odds of expressing satisfaction were lower among patients who had a chronic disease, a financial source other than National Health Insurance, experienced hospitalization within 1 year. CONCLUSION Our study results might be helpful for establishing a satisfactory pediatric emergency medical service system. In the future, further prospective studies evaluating the causal relationships between the relevant factors and patient satisfaction are warranted.

Background Transversus abdominis plane (TAP) block has been used as a component of multimodal analgesia after abdominal operation. We introduced a new laparoscope-assisted TAP (LTAP) block technique using intraperitoneal injection and compared its analgesic effect with that of an ultrasound-guided TAP (UTAP) block in terms of postoperative pain control. Study Design A prospective, randomized, single-blinded non-inferiority clinical trial was conducted with patients undergoing elective laparoscopic colectomy for colon cancer. Eighty patients were randomly assigned (1:1 ratio) to the UTAP and LTAP groups. At the end of the operation, opioid consumption and numeric rating scores (NRS; 0 [no pain] to 10 [worst pain]) of pain were recorded at 2, 6, 24, and 48 hours postoperatively and were compared between the groups. The primary end point was pain NRS during rest at 24 hours after operation. Results Thirty-eight patients in the LTAP group and 35 patients in the UTAP group completed the study protocol. We found no significant difference in mean ± SD pain NRS during rest at 24 hours between the LTAP group (3.90 ± 1.7) and the UTAP group (4.5 ± 1.9). The mean difference in pain NRS during rest at 24 hours was 0.57 (95% CI −0.26 to 1.41). Because the lower boundary of a 95% CI for the differences in pain NRS was > −1, non-inferiority was established. There was no significant difference between the groups in NRS pain during rest, NRS pain on movement, and postoperative morphine consumption during the 48 hours after operation. Conclusions These results show our new LTAP block technique was non-inferior to the ultrasound-guided technique in providing a TAP block after laparoscopic colorectal operation.

The olfactory technology as an Information and Communication Technology provides immersive user experience and makes affective enhancement in digital contents technology area. Olfactory contents technology is divided into olfactory information recognition and olfactory contents representation. The olfactory recognition technology is likely to be applied to the medical field by detecting specific gas compounds in breath of patients and the air quality monitoring. In this paper, taking into consideration of the Internet of things concepts and characteristics of sensors, describes the multi-purpose connected electronic nose system. Attaching the multi-sensors is important to detect the various features, and system management for usability and connectivity has advantages for efficiency and accuracy of the electronic nose system as a sensor node.

This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2013. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) The research works on the thermal and fluid engineering have been reviewed as groups of fluid machinery, pipes and relative parts including orifices, dampers and ducts, fuel cells and power plants, cooling and air-conditioning, heat and mass transfer, two phase flow, and the flow around buildings and structures. Research issues dealing with home appliances, flows around buildings, nuclear power plant, and manufacturing processes are newly added in thermal and fluid engineering research area. (2) Research works on heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer and industrial heat exchangers. Researches on heat transfer characteristics included the results for general analytical model for desiccant wheels, the effects of water absorption on the thermal conductivity of insulation materials, thermal properties of Octadecane/xGnP shape-stabilized phase change materials and CO2 and CO2-Hydrate mixture, effect of ground source heat pump system, the heat flux meter location for the performance test of a refrigerator vacuum insulation panel, a parallel flow evaporator for a heat pump dryer, the condensation risk assessment of vacuum multi-layer glass and triple glass, optimization of a forced convection type PCM refrigeration module, surface temperature sensor using fluorescent nanoporous thin film. In the area of pool boiling and condensing heat transfer, researches on ammonia inside horizontal smooth small tube, R1234yf on various enhanced surfaces, HFC32/HFC152a on a plain surface, spray cooling up to critical heat flux on a low-fin enhanced surface were actively carried out. In the area of industrial heat exchangers, researches on a fin tube type adsorber, the mass-transfer kinetics of a fin-tube-type adsorption bed, fin-and-tube heat exchangers having sine wave fins and oval tubes, louvered fin heat exchanger were performed. (3) In the field of refrigeration, studies are categorized into three groups namely refrigeration cycle, refrigerant and modeling and control. In the category of refrigeration cycle, studies were focused on the enhancement or optimization of experimental or commercial systems including a R410a VRF(Various Refrigerant Flow) heat pump, a R134a 2-stage screw heat pump and a R134a double-heat source automotive air-conditioner system. In the category of refrigerant, studies were carried out for the application of alternative refrigerants or refrigeration technologies including CO2 water heaters, a R1234yf automotive air-conditioner, a R436b water cooler and a thermoelectric refrigerator. In the category of modeling and control, Korean Journal of Air-Conditioning and Refrigeration Engineering Vol. 26, No. 12 (2014), pp.605-619 http://dx.doi.org/10.6110/KJACR.2014.26.12.605

Recently, multiple glazing units, frames, complex fenestration systems, and windows with shading devices havebeen developed to save cooling energy in buildings. However, very little work has been conducted on developing a directexperimental test method of the solar heat gain coefficient(SHGC) for new fenestration techniques. This study aims to developand evaluate a test apparatus to measure the SHGC, according to the KS L 9107 test method. The performance of thesolar simulator was class A, B, and A, for spectral match, non-uniformity, and instability irradiance, respectively. The differences between the measured and calculated SHGC values were found to range between 0.001 and 0.011, and for all test specimens they agreed within 4%. These results establish the validity of the test apparatus. This system is thus expectedto be useful in assessing the energy performance for various types of fenestration. Key words KS L 9107, SHGC(태양열 취득률), Fenestration(창호), Cooling energy (냉방에너지), Test method(시험법)†Corresponding author, E-mail

The read range of UHF mobile readers can be extended by a booster for mobile RFID readers (BoMR). But in an environment where multiple BoMRs are installed, the read success rate may be decreased due to signal interference. This paper proposes three arbitration methods based on interference estimation with the purpose of enhancing the read success rate. A central arbitration server manages global information in centralized arbitration method (CAM) without broadcast/multicast communication facility. In fully distributed arbitration method (FDAM), all the arbitration messages are broadcasted from a BoMR to every BoMR, and each BoMR decides with broadcasted global information. Events in FDAM are serialized naturally with broadcasted messages. Cluster Distributed Arbitration Method (CDAM) forms clusters with multicasted BoMRs and a selected BoMR acts as an arbiter in the cluster. Such effects as lengthened read range, improved the read success rates of readers can be obtained by the proposed methods without any hardware modification. In order to evaluate the arbitration methods, the RFID system is modeled by using the DEVS formalism and simulated by using the DEVSim++.

This paper presents a standalone photovoltaics system allowing power lines facilitated in wider range, and the power management system for its higher efficiency. The system could be widely used for logistics and transportation industry especially for electric vehicle, unmanned aerial vehicle, variable message signs and etc. The proposed power management system detects the battery and environment information first, and then, it controls each and every load to overly perform the battery operating time extension and component-to-system level protection from the over-charge/discharge. A power management system prototype was evaluated using a large-scale light-emitting diode display system, simulation works, and scenario model. The result highlights longer battery operating time (3.2%~9.6%).

Little data are available about the learning curve for robotic rectal resection.The purpose of this work was to provide a multidimensional analysis of the learning process in patients undergoing robotic total mesorectal excision for rectal cancer.This was a retrospective review of a prospectively collected database designed to evaluate the results of robotic rectal resection.The study was conducted at a tertiary-care hospital.From December 2007 to August 2012, 167 patients who underwent robotic total mesorectal excision for rectal cancer were included.A single hybrid variable including operative time, conversion, perioperative morbidity, and circumferential margin was generated to measure the success of the procedure. A moving average method for operative time and a risk-adjusted cumulative sum analysis were used to derive the learning curve.Overall conversion was noted in 2 cases (1.2%). The cumulative sum plot of a single hybrid variable representing the success of each operation demonstrated that the composite event was more frequent at the beginning of the series and began to decrease after 32 cases. The moving average for robotic console time decreased steadily and showed 2 plateaus; the first plateau was noted after 33 cases, and the second plateau was noted after 72 cases. The learning process was divided into 3 phases based on 2 cutoff points. The robotic console time decreased significantly with each phase (p0.001). Complicated rectal cancer was more frequent in the later phases; however, the incidence of postoperative complications remained constant throughout the series (p = 0.82).This study is limited by a single surgeon's experience.The learning process for robotic total mesorectal excision has a greater effect on the first 32 cases. These results help form a basis for performance monitoring of robotic total mesorectal excision.

The purpose of this study was to investigate the diagnostic performance of MRI in stratifying tumors stage III (T3) in patients with rectal cancer by measuring the extramural depth of tumor invasion based on the Radiologic Society of North America (RSNA) proposal and to validate its role as a prognostic indicator.From January 2006 to July 2009, 146 patients with surgically and pathologically confirmed T3 rectal adenocarcinoma who underwent preoperative MRI were enrolled. Two blinded radiologists measured the maximum extramural depth of tumor invasion on T2-weighted images. To evaluate the diagnostic performance of MRI for stratifying subgroups, the study population was assigned into three subgroups (T3a, T3b, and T3c) according to extramural depth of tumor invasion (5, 5-10, and10 mm).To validate the role of extramural depth of tumor invasion as a prognostic indicator, Cox regression analysis was used for estimation of independent risk factors for postoperative recurrence. Three-year recurrence-free survival was evaluated by the Kaplan-Meier method with a log-rank test. Histopathologic reports were used as the reference standard.The overall accuracy of MRI for stratifying subgroups was 71.2% (104/146) and 77.4% (113/146) for reviewers 1 and 2. Extramural depth of tumor invasion was an independent risk factor for 3-year recurrence-free survival (hazard ratio, 2.186; 95% CI, 1.336-3.577; p = 0.002). Kaplan-Meier curves revealed a significant difference in 3-year recurrence-free survival rates for each subgroup (86%, 69%, and 43% for T3a, T3b, and T3c; p0.03).MRI can be used for prognostic stratification according to extramural depth of tumor invasion based on the RSNA proposal for patients with T3 rectal cancer.

Assuming an association between cancer and metabolism, oncogene-directed metabolic reprogramming in cancer has revealed new target strategies. For example, the LKB1-AMPK-mTOR signaling pathway genes are already known to alter the cell metabolism and to play a critical role in the malignant behavior of cancer. Accordingly, based on the assumption that genetic variations in the LKB1-AMPK-mTOR signaling pathway can change the intracellular signal in terms of metabolic reprogramming, the present study analyzed 18 single nucleotide polymorphisms (SNPs) of the STK11, PRKAA1, TSC1/2, and mTOR genes and their impact on the survival of patients with colorectal cancer. Seven hundred seventy-two patients with surgically resected colorectal adenocarcinoma were enrolled in the present study. Eighteen SNPs were selected from an in silico analysis based on previous evidence of association. The SNP genotyping was performed using a SEQUENOM MassARRAY. Among the 18 polymorphisms, three SNPs (STK11 rs741765, PRKAA1 rs461404, and TSC1 rs13295634) were significantly associated with disease-free survival (DFS) or overall survival (OS). In a multivariate analysis, the GG genotype of STK11, TT genotype of PRKAA1, and TG or GG genotype of TSC1 were identified as independent prognostic factors for a worse DFS (hazard ratio = 1.398, 1.408, and 1.388; p = 0.030, 0.013, and 0.002, respectively) and OS (hazard ratio = 1.431, 1.680, and 1.394; p = 0.038, 0.001, and 0.009, respectively). The present results suggest that genetic variants of the STK11, PRKAA1, and TSC1 genes could be used as prognostic biomarkers for patients with surgically resected colorectal cancer.

The effect of Mg–Ti deoxidation on the solidification structure of advanced high strength steel was investigated by observing the solidification structure and also the inclusion particles. The effect of precipitation of TiN, MgO, and “TiN–MgO” hybrid inclusion on the formation of fine equiaxed crystals was evaluated. The composition of inclusions was observed to change in the order of MgO “MgO(core) + TiN(surface)” Ti2O3 by reaction time, which corresponded to the change of solidification structure as “columnar equiaxed columnar.” This could be understood from the concept of lattice disregistry in between delta iron and MgO (3.97%), TiN (3.91%), and Ti2O3 (18.9%). However, even with very low disregistry between delta iron and MgO, the MgO itself did not work as an effective catalyst, indicating that there is another criterion for determining a good catalyst. The mechanism of the formation of TiN on MgO surface was schematically described. The precipitation of TiN on MgO surface was feasible although the content of Ti and N was lower than the equilibrium solubility product for the formation of TiN. Because disregistry between TiN and MgO is very low (0.05%), the precipitation of TiN on the surface of MgO is energetically more favorable.

The ultimate goal of environmental buildings is to minimize the use of fossil fuels and resources while providing a comfortable environment for occupants. Through continuous research and development, the physical performance of the buildings has been greatly improved for this purpose. However, focusing only on physical performance, it is seen that there is a big discrepancy between predicted and actual performance of building by treating occupants, who are the most affective object of building and energy consumption, as simple passive elements. These results increase the energy and cost of the building and become an obstacle to the construction of environmentally friendly buildings. Among occupant behavior, window opening is the biggest factor of increasing heating and cooling energy consumption. The purpose of this paper is to analyze the ventilation rate of each window opening for being embedded in an energy simulation program. A method to analyze the ventilation rate was carbon dioxide decay method as shown in Fig. 1. As a result, the ventilation rate was affected by the wind direction and speed, and floor level, but was somewhat constant because of monsoon effect in summer and winter of Korea.

There have been many attempts to identify relationships among concepts corresponding to terms from biomedical information ontologies such as the Unified Medical Language System (UMLS). In particular, vector representation of such concepts using information from UMLS definition texts is widely used to measure the relatedness between two biological concepts. However, conventional relatedness measures have a limited range of applicable word coverage, which limits the performance of these models. In this paper, we propose a concept-embedding model of a UMLS semantic relatedness measure to overcome the limitations of earlier models. We obtained context texts of biological concepts that are not defined in UMLS by utilizing Wikipedia as an external knowledgebase. Concept vector representations were then derived from the context texts of the biological concepts. The degree of relatedness between two concepts was defined as the cosine similarity between corresponding concept vectors. As a result, we validated that our method provides higher coverage and better performance than the conventional method.

e15161 Background: Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision has become the standard treatment for locally advanced rectal cancer (LARC). However, the effect of CRT varies from complete response to complete resistance, and predicting response to CRT have not been well characterized yet. Previous studies have shown the potential of micro-RNA (miRNA) based approaches to enhance tumor radiation response. Accordingly, the present study attempted to identify biomarkers to predict response for preoperative CRT using comprehensive miRNA analysis in patients with LARC. Methods: This study included 65 rectal cancer tissues and 90 serum samples from patients who diagnosed with LACR and received preoperative CRT at Kyungpook National University Chilgok Hospital. Tissue specimens and serum samples were collected before CRT to evaluate the biologic differences between the good CRT response group and the poor CRT response group. For discovery of specific miRNAs, 800 miRNAs were analyzed using NanoString in 30 rectal cancer tissues. Thereafter, a total of 65 tissues, and 90 serum samples were investigated using real-time PCR for validation. Results: The median age was 59 years (range, 30-82), and the ratio of male to female was 3.05 to 1. The pathologic stages after preoperative CRT were as follows: pathologic complete response (n=13, 14.4%), pathologic stage I (n=13, 14.4%), pathologic stage II (n=27, 30.0%), pathologic stage III (n=28, 31.1%), and pathologic stage IV (n=9, 10.0%). In the discovery set, 16 target miRNAs were detected. In the validation set with tissue specimens, expression of 3 miRNAs (miR-199a/b-3p ( p=0.032), miR-199a-5p ( p=0.023), miR-199b-5p ( p=0.005)) was significantly upregulated which was associated with better response of CRT. Moreover, among the 3 candidate miRNAs, miR-199b-5p level was significantly upregulated in serum, and it was also found to be related with better response of CRT in LARC (pathologic stage 0/I versus II/III/IV, p=0.027). Conclusions: In the present study, high level of exosomal miR-199b-5p was associated with better response, suggesting it to be a promising non-invasive biomarker to predict response of CRT in patients with LARC. Accordingly, specific miRNAs can be predictive biomarker or therapeutic target to overcome radiotherapy resistance in LARC with a functional study.

27 Background: Gastric adenomas are considered premalignant, and some can be interpreted as cancer according to different pathologic guidelines. The dysplastic lesions share histologic characteristics including mucin phenotype that are related prognosis. The prognosis of the lesions has been studied but tends to be researched separately. Moreover, the proposed prognostic factors are mostly derived from the study of surgical specimens, and most of them did not consider the anatomical changes after surgery. Previously researched prognostic factors of gastric dysplasia were evaluated on the recurrence after complete resection with endoscopic procedure. Methods: From 2005 to 2016, 1678 gastric dysplasia were endoscopically removed in Soonchunhyang university hospital, Seoul. They were followed up with endoscopy under a standardized protocol. For the 716 lesions were histologically evaluated including mucin phenotype with immunohistochemical stain of MUC5AC, MUC6, MUC2, and CD10. Recurrence of dysplastic lesions were analyzed for the 688 lesions with at least 1 year’s follow-up. Results: Five-hundred and forty-three malignant lesions including in situ lesions were completely resected with endoscopic procedures. Endoscopic submucosal dissection was performed on 603 lesions and other lesions were removed with endoscopic mucosal resection. Submucosal invasion was on 83 lesions of carcinoma. The mucin phenotype of lesions was immunohistochemically evaluated. During median 40 months of follow-up, there was 89 cases of recurrence (12.9%). Kaplan-Meier analysis of the recurrence-free survival were estimated and the elderly over 65 years of age showed statistical significance (p = 0.039). Conclusions: Completely resected early stage of gastric dysplasia showed relatively low recurrence rate. Previously proposed histologic features did not affect prognosis. However, the age of patient showed statistical significance on recurrence-free survival. Regular surveillance on elderly patients is important to improve the clinical outcome of gastric dysplasia.

Purpose Rectovaginal fistula (RVF) after low anterior resection for rectal cancer is a type of anastomotic leakage. The aim of this study was to find out the difference of leakage, according to RVF presence or absence and to identify the optimal strategy for RVF. Methods All female patients who underwent low anterior resection with colorectal anastomosis or coloanal anastomosis (n = 950) were retrospectively analyzed. Patients' demographics and perioperative outcomes were analyzed between the RVF group and leakage without the RVF (nRVF) group. We performed 4 types of procedures—primary repair, diverting stoma, redo coloanal anastomosis (RCA), and conservative procedure—to treat RVF, and calculated the success rates of each type of procedure. Results The leakage occurred in 47 patients (4.9%). Among them, 18 patients (1.9%) underwent an RVF and 29 (3.0%) underwent nRVF. The RVF group received more perioperative radiotherapy (27.8% vs. 3.4%, P < 0.015) and occurred late onset after surgery (181.3 ± 176.4 days vs. 23.2 ± 53.6 days, P < 0.001) more than did the nRVF group. In multivariate analysis for the risk factor of the RVF group, the RVF group was statistically associated with less than 5 cm of anastomosis more than was the no-leakage group. A total of 35 procedures were performed in 18 patients with RVF for treatment. RCA showed satisfactory success rates (85.7%, n = 6) and, primary repair (transanal or transvaginal) showed acceptable success rate (33.3%, n = 8). Conclusion After low anterior resection for rectal cancer, RVF was strongly correlated with a lower level of primary tumor location. Among the patients who underwent leakages, receipt of perioperative radiotherapy was significantly high in the RVF group than that of the nRVF group. Additionally, this study suggests that RCA might be considered another successful treatment strategy for RVF.

In recent decades, a combination of cytoreductive surgery and intraperitoneal chemotherapy has yielded improvements in the survival of patients with peritoneal carcinomatosis. Laparoscopic cytoreductive surgery and intraperitoneal chemotherapy comprise a challenging and rarely reported surgical procedure. Between November 2004 and February 2010, 29 patients underwent cytoreductive surgery and early postoperative intraperitoneal chemotherapy for peritoneal carcinomatosis secondary to colorectal cancer. Of the 29 patients, 15 underwent laparoscopic surgery and 14 underwent open surgery. The patient characteristics did not differ significantly between the two groups. Synchronous peritoneal carcinomatosis with a primary tumor was more common in the laparoscopic group, and the Gilly stage of peritoneal carcinomatosis was found more frequently in the open group. Complication rate and hospital stay were less in the laparoscopic group. However, the outcomes for the patients undergoing the combined treatment were similar between the two groups with respect to completeness of cytoreduction, operation morbidity, and overall survival. The laparoscopic group had a cytoreduction completeness of 86.7 % and an operative morbidity of 13.3 %. Operative mortality occurred for one patient after open surgery. Laparoscopic cytoreductive surgery and early postoperative intraperitoneal chemotherapy can be performed safely for selected patients with peritoneal carcinomatosis from colorectal cancer to a limited extent. Further studies with longer follow-up periods and larger numbers of patients are warranted to confirm the study findings.

Urinary and sexual dysfunction are recognized complications of rectal cancer surgery in men. This study compared robot-assisted total mesorectal excision (RTME) and laparoscopic total mesorectal excision (LTME) with regard to these functional outcomes. A series of 32 men who underwent RTME between February 1, 2009 and December 31, 2010 were matched 1:1 with patients who underwent LTME. The matching criteria were age, body mass index, tumor distance from the anal verge, neoadjuvant chemoradiation therapy, and tumor stage. Urinary and erectile function were evaluated using the International Prostatic Symptom Score (IPSS) and the five-item version of the International Index of Erectile Function (IIEF-5) scale. Data were collected from the two groups at baseline and at 3, 6, and 12 months after surgery and compared. The mean IPSS score did not differ between the two groups at baseline at any point of measurement. The mean baseline IIEF-5 score was similar between the two groups and was decreased at 3 months. The mean IIEF-5 score was significantly higher in the RTME group at 6 months than in the LTME group (14.1 ± 6.1 vs. 9.4 ± 6.6; p = 0.024). The interval decrease in IIEF-5 scores was significantly higher in the LTME group than in the RTME group at 6 months (4.9 ± 4.5 vs. 9.2 ± 4.7; p = 0.030). The men in the RTME group experienced earlier restoration of erectile function than did those in the LTME group. Bladder function was similar during the 12 months after RTME or LTME.

The thermodynamic equilibria between CaO-Al2O3-SiO2-CaF2-MgO(-MnO) slag and Fe-1.5 mass pct Mn-0.5 mass pct Si-0.5 mass pct Cr melt was investigated at 1873 K (1600 °C) in order to understand the effect of slag composition on the concentration of Al2O3 in the inclusions in Si-Mn-killed steels. The composition of the inclusions were mainly equal to (mol pct MnO)/(mol pct SiO2) = 0.8(±0.06) with Al2O3 content that was increased from about 10 to 40 mol pct by increasing the basicity of slag (CaO/SiO2 ratio) from about 0.7 to 2.1. The concentration ratio of the inclusion components, $$ {{X_{{{\text{Al}}_{2} {\text{O}}_{3} }} \cdot X_{\text{MnO}} } \mathord{\left/ {\vphantom {{X_{{{\text{Al}}_{2} {\text{O}}_{3} }} \cdot X_{\text{MnO}} } {X_{{{\text{SiO}}_{2} }} }}} \right. \kern-0pt} {X_{{{\text{SiO}}_{2} }} }} $$ , and the activity ratio of the steel components, $$ {{a_{\text{Al}}^{2} \cdot a_{\text{Mn}} \cdot a_{\text{O}}^{2} } \mathord{\left/ {\vphantom {{a_{\text{Al}}^{2} \cdot a_{\text{Mn}} \cdot a_{\text{O}}^{2} } {a_{\text{Si}} }}} \right. \kern-0pt} {a_{\text{Si}} }} $$ , showed a good linear relationship on a logarithmic scale, indicating that the activity coefficient ratio of the inclusion components, $$ {{\gamma_{{{\text{SiO}}_{2} }}^{i} } \mathord{\left/ {\vphantom {{\gamma_{{{\text{SiO}}_{2} }}^{i} } {\left( {\gamma_{{{\text{Al}}_{2} {\text{O}}_{3} }}^{i} \cdot \gamma_{\text{MnO}}^{i} } \right)}}} \right. \kern-0pt} {\left( {\gamma_{{{\text{Al}}_{2} {\text{O}}_{3} }}^{i} \cdot \gamma_{\text{MnO}}^{i} } \right)}} $$ , was not significantly changed. From the slag-steel-inclusion multiphase equilibria, the concentration of Al2O3 in the inclusions was expressed as a linear function of the activity ratio of the slag components, $$ {{a_{{{\text{Al}}_{2} {\text{O}}_{3} }}^{s} \cdot a_{\text{MnO}}^{s} } \mathord{\left/ {\vphantom {{a_{{{\text{Al}}_{2} {\text{O}}_{3} }}^{s} \cdot a_{\text{MnO}}^{s} } {a_{{{\text{SiO}}_{2} }}^{s} }}} \right. \kern-0pt} {a_{{{\text{SiO}}_{2} }}^{s} }} $$ on a logarithmic scale. Consequently, a compositional window of the slag for obtaining inclusions with a low liquidus temperature in the Si-Mn-killed steel treated in an alumina ladle is recommended.

Purpose We compared the outcomes of total knee arthroplasty (TKA) using the Genesis II prosthesis in which 3° of external rotation was incorporated into the femoral component and Nexgen LPS prosthesis in which the degree of external rotation was determined by the extent of intraoperative bone cutting. Materials and Methods Of the patients who underwent TKA for osteoarthritis between November 2006 and December 2009, 326 patients (572 knees) were included in this study. The prosthesis of choice was Genesis II in 199 knees and Nexgen LPS in 373 knees. The mean follow-up was 27 months (range, 24 to 51 months). The American Knee Society score (KSS) and function score (FS) were used for clinical assessments. The maximum flexion angle and patellar tilt were compared between the groups. Results At the final follow-up, no significant intergroup difference was observed regarding the KSS (p=0.217), FS (p=0.238), maximum flexion angle (p=0.124), and patellar tilt (p=0.156). Conclusions There was no significant difference in the clinical outcomes and patellar tilt between the prosthesis in which 3° of external rotation was incorporated into the femoral component and the prosthesis in which external rotation was determined based on bone cutting.

Wireless power transmission technology has been studied variety. Recently, wireless power transmission technology used by resonance and magnetic induction field is applied to various fields. However, magnetic resonance and inductive coupling are have drawbacks - power transmission distance is short. Microwave transmission and accept techniques have been developed to overcome short distance. However, improvement in efficiency is required. This paper, propose a high-efficiency microwave energy acceptor IC(EAIC). Suggested EAIC is consists of RF-DC converter and DC-DC converter. Wide Input power range is -15 dBm ~ 20 dBm. And output voltage is boosted up to 5.5 V by voltage boost-up circuit. EAIC can keep the output voltage constant. Available efficiency of RF-DC converter is 95.5 % at 4 dBm input. And DC-DC efficiency is 94.79 % at 1.1 mA load current. Fully EAIC efficiency is 90.5 %.

In this paper, a unified media application processor (UMAP) is presented for 2D/3D image analysis/synthesis applications on handheld devices. UMAP integrates parallel and sequential processing layers which consist of heterogeneous functional IPs for general media contents processing on today's application processors (AP). Based on the heterogeneous many-core platform, UMAP supports not only graphics and vision processing for real-time augmented reality (AR) but also disparity estimation and 3D display synthesis for 3D-view AR acceleration. A new concept of 3D-view AR which synthesizes 3D display contents from two vertically aligned stereo images and a self-constructed disparity map is introduced to achieve true realism for next generation mobile devices. For low-cost 3D-view AR processing, a homography-based disparity estimation (HDE) algorithm is proposed to construct a disparity map between two stereo images with small implementation overhead. For real-time and energy-efficient system organization, workload-balanced 3-stage pipelined architecture and a mixed-mode feature extraction engine (FEE) are also implemented in UMAP. The 3-stage pipelined system which consists of graphics, vision, and display operation stages reduces per-frame execution latency, while dynamic analog/digital mode reconfiguration based on mixed-mode FEE reduces per-frame energy dissipation, so real-time energy-efficient 3D-view AR can be realized in UMAP. FEE performs high-speed corner detection for vision processing based on four pairs of analog current contention logics (CCLs). Especially, a diode-connected current sensing stabilizer (CSS) in each CCL reduces minimum sensing current for corner detection, so average power consumed in CCL is reduced by 44.9%. In 2D or 3D-view AR processing, FEE with four CCLs replaces the parallel processing core cluster which is the most power hungry IP in UMAP, so 96.7% of cluster power and 99.1% of target detection time are saved in real operation. Based on the 3-stage pipelined architecture with the dynamic mode reconfiguration technique, the entire UMAP achieves up to 64.4% of energy reduction compared to the previous state-of-the-art media processors in full operation.

Conditions that overlay multicast tree must satisfy for the real-time application system of a video-conference, an internet broadcasting is two things. First, the degree of nodes in a tree must be proper value. Second, the diameter of the multicast tree, distance between longest two users should be short. If the path between two users in the tree is long, the delay time in data transmission between two users great. So, it is not suitable to the application system such as video-conferences. In this paper, the cost of the dijkstra algorithm calculate with proposed score-function through checking the extra bandwidth, the delay and the requested bandwidth. It is composed the tree through the dijkstra algorithm. Key Words : Degree of node, Dijkstra algorithm, Overlay multicast 본 연구는 미래창조과학부 및 정보통신산업진흥원의 대학IT연구센터육성 지원사업의 연구결과로 수행되었음" (NIPA-2013- H0301-13-1006) * Corresponding Author : Hyung-Ok Lee(Chonnam Univ.) Tel: +82-62-530-0422 email: narcis99@nate.com Received April 5, 2013 Revised May 27, 2013 Accepted July 11, 2013

This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2012. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. The conclusions are as follows : (1) The research works on thermal and fluid engineering have been reviewed as groups of fluid machinery, pipes and valves, fuel cells and power plants, ground-coupled heat pumps, and general heat and mass transfer systems. Research issues are mainly focused on new and renewable energy systems, such as fuel cells, ocean thermal energy conversion power plants, and ground-coupled heat pump systems. (2) Research works on the heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer, and industrial heat exchangers. Researches on heat transfer characteristics included the results for natural convection in a square enclosure with two hot circular cylinders, non-uniform grooved tube considering tube expansion, single-tube annular baffle system, broadcasting LED light with ion wind generator, mechanical property and microstructure of SA213 P92 boiler pipe steel, and flat plate using multiple tripping wires. In the area of pool boiling and condensing heat transfer, researches on the design of a micro-channel heat exchanger for a heat pump, numerical simulation of a heat pump evaporator considering the pressure drop in the distributor and capillary tubes, critical heat flux on a thermoexcel-E enhanced surface, and the performance of a fin-and-tube condenser with non-uniform air distribution and different tube types were actively carried out. In the area of industrial heat exchangers, researches on a plate heat exchanger type dehumidifier, fin-tube heat exchanger, an electric circuit transient analogy model in a vertical closed loop ground heat exchanger, heat transfer characteristics of a double skin window for plant factory, a regenerative heat exchanger depending on its porous structure, and various types of plate heat exchangers were performed. (3) In the field of refrigeration, various studies were executed to improve refrigeration system performance, and to evaluate the applicability of alternative refrigerants and new components. Various topics were presented in the area of refrigeration cycle. Research issues mainly focused on the enhancement of the system performance. In the alternative refrigerant area, studies on CO2, R32/R152a mixture, and R1234yf were performed. Studies on the design and performance analysis of various compressors and evaporator were executed. (4) In building mechanical system research fields, twenty-nine studies were conducted to achieve effective design of mechanical systems, and also to maximize the energy efficiency of buildings. The topics of the studies included heating and cooling, HVAC system, ventilation, renewable energy systems, and lighting systems in buildings. New designs and performance tests using numerical methods and experiments provide useful information and key data, which can improve the energy efficiency of buildings. (5) In the fields of the architectural environment, studies for various purposes, such as indoor environment, building energy, and renewable energy were performed. In particular, building energy-related researches and renewable energy systems have been mainly studied, reflecting interests in global climate change, and efforts to reduce building energy consumption by government and architectural specialists. In addition, many researches have been conducted regarding indoor environments.

A pattern-matching based image recognition accelerator (PRA) is presented for embedded vision applications. It is a hardware accelerator that performs interest point detection and matching for image-based recognition applications in real time in both mobile devices and vehicles. The proposed system is implemented as a small IP, and it has eight times higher throughput than state-of-the-art object recognition processors, which are implemented based on a heterogeneous many-core system. PRA has three key features: 1) joint algorithm–architecture optimizations for exploiting bit-level parallelism; 2) a low-power unified hardware platform for interest point detection and matching; and 3) scalable hardware architecture. PRA achieves $9.5\times$ performance improvement with only 30% of logic gates including static random-access memory (SRAM) compared to the state-of-the-art object recognition processors. It consists of 78.3 k logic gates and 128 kB SRAM, which are integrated in a test chip implemented for PRA verification. It achieves 94.3 frames per second (fps) in 1080 p full HD resolution at 200-MHz operating frequency while consuming 182 mW. Each complete operation for interest point detection and matching requires 2.09 cycles and 8 cycles on average, respectively, based on a unified bit-level matching accelerator, which is implemented only with 680 logic gates.

To assess the risk factors for clinical anastomotic leakage (AL) in patients undergoing laparoscopic surgery for rectal cancer.Little data are available about risk factors for AL after laparoscopic rectal cancer resection.This was a retrospective analysis of 1609 patients with rectal cancer who had undergone laparoscopic surgery for rectal cancer with sphincter preservation. Clinical data related to AL were collected from 11 institutions. Univariate and multivariate analyses were performed to determine the risk factors for AL.AL was noted in 101 (6.3%) of the patients. The leakage rate ranged from 2.0% to 10.3% for each hospital (P = 0.04). In patients without protective stomas (n = 1187), male sex [hazard ratio (HR), 3.468], advanced tumor stage (HR, 2.520), lower tumor level (HR, 2.418), preoperative chemoradiation (HR, 6.284), perioperative transfusion (HR, 10.705), and multiple firings of the linear stapler (HR, 6.181) were significantly associated with AL. Our theoretical model suggested that the HR for patients with 2 risk factors was significantly higher than that the HR for patients with no or only 1 risk factor.Male sex, low anastomosis, preoperative chemoradiation, advanced tumor stage, perioperative bleeding, and multiple firings of the linear stapler increased the risk of AL after laparoscopic surgery for rectal cancer. A diverting stoma might be mandatory in patients with 2 or more of the risk factors identified in this analysis.