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202. Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristics

Author

Demark‐Wahnefried, Wendy, primary, Rogers, Laura Q., additional, Gibson, Justin T., additional, Harada, Shuko, additional, Frugé, Andrew D., additional, Oster, Robert A., additional, Grizzle, William E., additional, Norian, Lyse A., additional, Yang, Eddy S., additional, Della Manna, Deborah, additional, Jones, Lee W., additional, Azrad, Maria, additional, and Krontiras, Helen, additional

Published
2020
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203. Abnormal body composition is a predictor of adverse outcomes after autologous haematopoietic cell transplantation

Author

Armenian, Saro H., primary, Iukuridze, Aleksi, additional, Teh, Jennifer Berano, additional, Mascarenhas, Kristen, additional, Herrera, Alex, additional, McCune, Jeannine S., additional, Zain, Jasmine M., additional, Mostoufi‐Moab, Sogol, additional, McCormack, Shana, additional, Slavin, Thomas P., additional, Scott, Jessica M., additional, Jones, Lee W., additional, Sun, Can‐Lan, additional, Forman, Stephen J., additional, Wong, F. Lennie, additional, and Nakamura, Ryotaro, additional

Published
2020
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204. Association of post-diagnosis cardiorespiratory fitness with cause-specific mortality in cancer

Author

Groarke, John D, primary, Payne, David L, additional, Claggett, Brian, additional, Mehra, Mandeep R, additional, Gong, Jingyi, additional, Caron, Jesse, additional, Mahmood, Syed S, additional, Hainer, Jon, additional, Neilan, Tomas G, additional, Partridge, Ann H, additional, Di Carli, Marcelo, additional, Jones, Lee W, additional, and Nohria, Anju, additional

Published
2020
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206. Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer

Author

Scott, Jessica M., primary, Thomas, Samantha M., additional, Peppercorn, Jeffrey M., additional, Herndon, James E., additional, Douglas, Pamela S., additional, Khouri, Michel G., additional, Dang, Chau T., additional, Yu, Anthony F., additional, Catalina, Diane, additional, Ciolino, Cristi, additional, Capaci, Catherine, additional, Michalski, Meghan G., additional, Eves, Neil D., additional, and Jones, Lee W., additional

Published
2020
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207. Abstract P5-12-09: Patient-reported outcomes (PROs) during one year of adjuvant enzalutamide for the treatment of early stage androgen receptor positive (AR+) triple negative breast cancer

Author

Traina, Tiffany A, primary, Jones, Lee W, additional, Blinder, Victoria, additional, Scott, Jessica, additional, Boyle, Leigh Ann, additional, Arumov, Artavazd, additional, Alano, Tina, additional, Patil, Sujata, additional, DeFusco, Patricia, additional, Lamparella, Nicholas, additional, Robson, Mark, additional, and Gucalp, Ayca, additional

Published
2020
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209. Body weight and return to work among survivors of early-stage breast cancer

Author

Di Meglio, Antonio, primary, Menvielle, Gwenn, additional, Dumas, Agnes, additional, Gbenou, Arnauld, additional, Pinto, Sandrine, additional, Bovagnet, Thomas, additional, Martin, Elise, additional, Ferreira, Arlindo R., additional, Vanlemmens, Laurence, additional, Arsene, Olivier, additional, Ibrahim, Mahmoud, additional, Wassermann, Johanna, additional, Martin, Anne Laure, additional, Lemonnier, Jerome, additional, Del Mastro, Lucia, additional, Jones, Lee W., additional, Partridge, Ann H., additional, Ligibel, Jennifer A., additional, Andre, Fabrice, additional, Michiels, Stefan, additional, and Vaz Luis, Ines, additional

Published
2020
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218. Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial.

Author

Scott, Jessica M., Thomas, Samantha M., Herndon, James E., Douglas, Pamela S., Yu, Anthony F., Rusch, Valerie, Huang, James, Capaci, Catherine, Harrison, Jenna N., Stoeckel, Kurtis J., Nilsen, Tormod, Edvardsen, Elisabeth, Michalski, Meghan G., Eves, Neil D., and Jones, Lee W.

Subjects
EXERCISE therapy, CARDIOPULMONARY fitness, LUNG cancer, RANDOMIZED controlled trials, BODY composition, AEROBIC exercises
Abstract

Background: Poor cardiorespiratory fitness (CRF) is a cardinal feature of post‐treatment primary lung cancer. The most effective exercise therapy regimen to improve CRF has not been determined. Methods: In this parallel‐group factorial randomized controlled trial, lung cancer survivors with poor CRF (below age–sex sedentary values) were randomly allocated to receive 48 consecutive supervised sessions thrice weekly of (i) aerobic training (AT)—cycle ergometry at 55% to >95% of peak oxygen consumption (VO2peak); (ii) resistance training (RT)—lower and upper extremity exercises at 50–85% of maximal strength; (iii) combination training (CT)—AT plus RT; or (iv) stretching attention control (AC) for 16 weeks. The primary endpoint was change in CRF (VO2peak, mL O2·kg−1·min−1). Secondary endpoints were body composition, muscle strength, patient‐reported outcomes, tolerability (relative dose intensity of exercise), and safety. Analysis of covariance determined change in primary and secondary endpoints from baseline to post‐intervention (Week 17) with adjustment for baseline values of the endpoint and other relevant clinical covariates. Results: Ninety patients (65 ± 9 years; 66% female) were randomized (AT, n = 24; RT, n = 23; CT, n = 20; and AC, n = 23) of the planned n = 160. No serious adverse events were observed. For the overall cohort, the lost‐to‐follow‐up rate was 10%. Mean attendance was ≥75% in all groups. In intention‐to‐treat analysis, VO2peak increased 1.1 mL O2·kg−1·min−1 [95% confidence interval (CI): 0.0, 2.2, P = 0.04] and 1.4 mL O2·kg−1·min−1 (95% CI: 0.2, 2.5, P = 0.02) in AT and CT, respectively, compared with AC. There was no difference in VO2peak change between RT and AC (−0.1 mL O2·kg−1·min−1, 95% CI: −1.2, 1.0, P = 0.88). Favourable improvements in maximal strength and body composition were observed in RT and CT groups compared with AT and AC groups (Ps < 0.05). No between‐group changes were observed for any patient‐reported outcomes. Relative dose intensity of exercise was lower in RT and CT compared with AT (Ps < 0.05). Conclusions: In the context of a smaller than planned sample size, AT and CT significantly improved VO2peak in lung cancer survivors; however, the tolerability‐to‐benefit ratio was superior for AT and hence may be the preferred modality to target impaired CRF in post‐treatment lung cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2021
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238. Feasibility, Safety, and Efficacy of Aerobic Training in Pretreated Patients with Metastatic Breast Cancer: A Randomized Controlled Trial

Author

Scott, Jessica M., Iyengar, Neil M., Nilsen, Tormod S., Michalski, Meghan, Thomas, Samantha M., Herndon, James, Sasso, John, Yu, Anthony, Chandarlapaty, Sarat, Dang, Chau T., Comen, Elizabeth A., Dickler, Maura N., Peppercorn, Jeffrey M., and Jones, Lee W.

Subjects
Adult, Breast Neoplasms, Middle Aged, Article, Exercise Therapy, Young Adult, Oxygen Consumption, Treatment Outcome, Quality of Life, Feasibility Studies, Humans, Female, Patient Reported Outcome Measures, Exercise, Aged
Abstract

BACKGROUND: Investigation of exercise training in metastatic breast cancer has received minimal attention. We determined the feasibility and safety of aerobic training in metastatic breast cancer. METHODS: 65 women (21 to 80 years) with metastatic (stage IV) breast cancer (57% receiving chemotherapy; >40% ≥ 2 lines of prior therapy) were allocated to an aerobic training (n=33) or stretching (n=32) group. Aerobic training consisted of 36 supervised treadmill walking sessions delivered thrice-weekly between 55% to 80% of peak oxygen consumption (VO(2peak)) for 12 consecutive weeks. Stretching was matched to aerobic training on location, frequency, duration, and intervention length. The primary end point was aerobic training feasibility a priori defined as rate of lost to follow up (LTF) (0.05). Per protocol analyses indicated 14 of 33 (42%) patients receiving aerobic training had acceptable tolerability (relative dose intensity ≥70%), which led to improvements in VO(2)peak and functional capacity (p’s

Published
2018

240. Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors

Author

Meyerhardt, Jeffrey A, primary, Irwin, Melinda L, primary, Jones, Lee W, primary, Zhang, Sui, primary, Campbell, Nancy, primary, Brown, Justin C, primary, Pollak, Michael, primary, Sorrentino, Alexandra, primary, Cartmel, Brenda, primary, Harrigan, Maura, primary, Tolaney, Sara M, primary, Winer, Eric, primary, Ng, Kimmie, primary, Abrams, Thomas, primary, Fuchs, Charles S, primary, Sanft, Tara, primary, Douglas, Pamela S, primary, Hu, Frank, primary, and Ligibel, Jennifer A, primary

Published
2019
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244. Clonal Hematopoiesis

Author

Libby, Peter, primary, Sidlow, Robert, additional, Lin, Amy E., additional, Gupta, Dipti, additional, Jones, Lee W., additional, Moslehi, Javid, additional, Zeiher, Andreas, additional, Jaiswal, Siddhartha, additional, Schulz, Christian, additional, Blankstein, Ron, additional, Bolton, Kelly L., additional, Steensma, David, additional, Levine, Ross L., additional, and Ebert, Benjamin L., additional

Published
2019
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246. Oncologists’ Attitudes and Practice of Addressing Diet, Physical Activity, and Weight Management With Patients With Cancer: Findings of an ASCO Survey of the Oncology Workforce

Author

Ligibel, Jennifer A., primary, Jones, Lee W., additional, Brewster, Abenaa M., additional, Clinton, Steven K., additional, Korde, Larissa A., additional, Oeffinger, Kevin C., additional, Bender, Catherine M., additional, Tan, Winston, additional, Merrill, Janette K., additional, Katta, Sweatha, additional, and Alfano, Catherine M., additional

Published
2019
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247. Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Author

Tonorezos, Emily S., primary, Ford, Jennifer S., additional, Wang, Linwei, additional, Ness, Kirsten K., additional, Yasui, Yutaka, additional, Leisenring, Wendy, additional, Sklar, Charles A., additional, Robison, Leslie L., additional, Oeffinger, Kevin C., additional, Nathan, Paul C., additional, Armstrong, Gregory T., additional, Krull, Kevin, additional, and Jones, Lee W., additional

Published
2019
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248. Impact of Sarcopenia on Adverse Outcomes After Allogeneic Hematopoietic Cell Transplantation

Author

Armenian, Saro H, primary, Xiao, Meisi, additional, Berano Teh, Jennifer, additional, Lee, Brandyn, additional, Chang, Howard A, additional, Mascarenhas, Kristen, additional, Lee, Sean, additional, Iukuridze, Alex, additional, Xie, Jack J, additional, Scott, Jessica M, additional, Jones, Lee W, additional, Lennie Wong, F, additional, Forman, Stephen J, additional, and Nakamura, Ryotaro, additional

Published
2019
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250. A randomized controlled trial comparing changes in fitness with or without supervised exercise in patients initiated on enzalutamide and androgen deprivation therapy for non-metastatic castration-sensitive prostate cancer (EXTEND)

Author

Harrison, Michael R., Davis, Paul G., Khouri, Michel G., Bartlett, David B., Gupta, Rajan T., Armstrong, Andrew J., McNamara, Megan A., Zhang, Tian, Anand, Monika, Onyenwoke, Kelly, Edwardson, Sara, Craig, Danielle, Michalski, Meghan, Wu, Yuan, Oyekunle, Taofik, Coyne, Brian, Coburn, Aubrie, Jones, Lee W., and George, Daniel J.

Abstract

Background: Androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI) are associated with deleterious physical effects, which exercise may mitigate; however, exercise has never been studied in patients initiating treatment with ADT and an ARSI. Our objective was to determine whether supervised exercise prior to and during initial therapy could mitigate adverse effects of ADT plus enzalutamide. Methods: We conducted a single center trial in patients with recurrent prostate cancer treated with ADT and enzalutamide. We randomized 26 patients to 16 weeks of supervised exercise (aerobic and resistance), starting 4 weeks before initiation of ADT and enzalutamide, or usual care. The primary endpoint was change in peak oxygen uptake (VO2peak) as a measure of cardiorespiratory fitness (CRF). Secondary endpoints were functional capacity, maximal strength, body composition, patient-reported outcomes, safety, and feasibility. Analysis of covariance was used to compare outcomes for groups at Week 17 adjusted for baseline values. Results: The usual care group (N= 13) showed declines from baseline to week 17 in both absolute CRF (−0.31 L/min, −10.9%; p&lt; 0.01) and relative CRF (−3.2 mL/kg/min, −8.9%; p= 0.04); worse fatigue (p= 0.01); and worse quality of life (p= 0.01). At week 17, the exercise group (N= 13) demonstrated improved absolute CRF (between-group change +0.20 L/min, p= 0.05), leg strength (+48.6 kg, p&lt; 0.01) and functional capacity (+21.0 m, p= 0.01) at week 17. Conclusions: This is the first randomized controlled trial demonstrating a clinically significant decline in CRF in patients initiating ADT and enzalutamide. We show the effectiveness of short-term supervised exercise to mitigate declines in absolute CRF, and improve maximal leg strength and functional capacity. ClinicalTrials.gov Identifier: NCT02256111

Published
2022
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