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1,446 results on '"Jones, Karen L"'

203. Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution

Author

Jalleh, Ryan, primary, Pham, Hung, additional, Marathe, Chinmay S., additional, Wu, Tongzhi, additional, Buttfield, Madeline D., additional, Hatzinikolas, Seva, additional, Malbert, Charles H., additional, Rigda, Rachael S., additional, Lange, Kylie, additional, Trahair, Laurence G., additional, Feinle-Bisset, Christine, additional, Rayner, Christopher K., additional, Horowitz, Michael, additional, and Jones, Karen L., additional

Published
2020
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205. Effects of sustained treatment with lixisenatide on gastric emptying and postprandial glucose metabolism in type 2 diabetes: a randomized controlled trial

Author

Rayner, Christopher K., primary, Watson, Linda E., primary, Phillips, Liza K., primary, Lange, Kylie, primary, Bound, Michelle J., primary, Grivell, Jacqueline, primary, Wu, Tongzhi, primary, Jones, Karen L., primary, Horowitz, Michael, primary, Ferrannini, Ele, primary, Tricò, Domenico, primary, Frascerra, Silvia, primary, Mari, Andrea, primary, and Natali, Andrea, primary

Published
2020
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208. Exenatide once weekly slows gastric emptying of solids and liquids in healthy, overweight people at steady‐state concentrations

Author

Jones, Karen L., primary, Huynh, Lian Q., additional, Hatzinikolas, Seva, additional, Rigda, Rachael S., additional, Phillips, Liza K., additional, Pham, Hung T., additional, Marathe, Chinmay S., additional, Wu, Tongzhi, additional, Malbert, Charles H., additional, Stevens, Julie E., additional, Lange, Kylie, additional, Rayner, Christopher K., additional, and Horowitz, Michael, additional

Published
2020
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212. Author Correction: Nanopore native RNA sequencing of a human poly(A) transcriptome

Author

Workman, Rachael E., primary, Tang, Alison D., additional, Tang, Paul S., additional, Jain, Miten, additional, Tyson, John R., additional, Razaghi, Roham, additional, Zuzarte, Philip C., additional, Gilpatrick, Timothy, additional, Payne, Alexander, additional, Quick, Joshua, additional, Sadowski, Norah, additional, Holmes, Nadine, additional, de Jesus, Jaqueline Goes, additional, Jones, Karen L., additional, Soulette, Cameron M., additional, Snutch, Terrance P., additional, Loman, Nicholas, additional, Paten, Benedict, additional, Loose, Matthew, additional, Simpson, Jared T., additional, Olsen, Hugh E., additional, Brooks, Angela N., additional, Akeson, Mark, additional, and Timp, Winston, additional

Published
2019
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219. Gastric Function

Author

Horowitz, Michael, primary, Jones, Karen L., additional, Akkermans, Louis M. A., additional, and Samsom, Melvin, additional

Published
2005
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223. Improving adult immunization rates in primary care clinics

Author

Jones, Karen L., Hammer, Anne L., Swenson, Carolyn, Appel, Alicia, Phibbs, Stephanie, Hill, Felicia, and Kennedy, Oddie

Subjects
Company business management, United States. Centers for Medicare and Medicaid Services -- Management, Adults -- Health aspects, Immunization -- Statistics, Immunization -- Health aspects
Abstract

EXECUTIVE SUMMARY * The goal of this effort was to improve adult immunization rates within a large urban health care system. * To measure improvement efforts, we calculated each month the percentage of adults 65 years and older who leave clinic visits with up-to-date pneumococcal vaccination were calculated. * This was accomplished through the development of three key aspects: standing orders, an immunization registry, and an algorithm to recommend vaccinations based on age and past vaccination history, but also on health history and risk factors for specific diseases., IF YOU WERE LOOKING TO purchase health insurance for yourself or perhaps the company for whom you work, the first stop you might make would be the National Committee for [...]

Published
2008

225. Effects of meal volume and posture on gastric emptying of solids and appetite

Author

Doran, Selena, Jones, Karen L., Andrews, Jane M., and Horowitz, Michael

Subjects
Appetite -- Physiological aspects, Stomach -- Physiological aspects, Biological sciences
Abstract

The effects of meal volume and subject posture on gastric emptying time were investigated in eight normal subjects who consumed either a large or small meal volume and made to lie on the left lateral decubitus position or remain sitting after the meal. Results reveal that meal volume increases gastric emptying time in a direct relationship. Posture had no effect on the emptying time of the stomach.

Published
1998

229. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age

Author

Cook, Caroline G., Andrews, Jane M., Jones, Karen L., Wittert, Gary A., Chapman, Ian M., Morley, John E., and Horowitz, Michael

Subjects
Pylorus -- Research, Intestine, Small -- Research, Old age -- Research, Biological sciences
Abstract

The effect of healthy aging on small intestinal nutrient infusion affecting appetite and pyloric motility was examined on healthy young and old male subjects Results of the research revealed that the effect of the stimulation of phasic pyloric pressure waves increased in healthy persons as compared to younger ones. Furthermore, increased feedback from small intestinal nutrients is not responsible for the physiological anorexia of aging.

Published
1997

233. Nanopore native RNA sequencing of a human poly(A) transcriptome.

Author

Workman, Rachael E, Workman, Rachael E, Tang, Alison D, Tang, Paul S, Jain, Miten, Tyson, John R, Razaghi, Roham, Zuzarte, Philip C, Gilpatrick, Timothy, Payne, Alexander, Quick, Joshua, Sadowski, Norah, Holmes, Nadine, de Jesus, Jaqueline Goes, Jones, Karen L, Soulette, Cameron M, Snutch, Terrance P, Loman, Nicholas, Paten, Benedict, Loose, Matthew, Simpson, Jared T, Olsen, Hugh E, Brooks, Angela N, Akeson, Mark, Timp, Winston, Workman, Rachael E, Workman, Rachael E, Tang, Alison D, Tang, Paul S, Jain, Miten, Tyson, John R, Razaghi, Roham, Zuzarte, Philip C, Gilpatrick, Timothy, Payne, Alexander, Quick, Joshua, Sadowski, Norah, Holmes, Nadine, de Jesus, Jaqueline Goes, Jones, Karen L, Soulette, Cameron M, Snutch, Terrance P, Loman, Nicholas, Paten, Benedict, Loose, Matthew, Simpson, Jared T, Olsen, Hugh E, Brooks, Angela N, Akeson, Mark, and Timp, Winston

Abstract

High-throughput complementary DNA sequencing technologies have advanced our understanding of transcriptome complexity and regulation. However, these methods lose information contained in biological RNA because the copied reads are often short and modifications are not retained. We address these limitations using a native poly(A) RNA sequencing strategy developed by Oxford Nanopore Technologies. Our study generated 9.9 million aligned sequence reads for the human cell line GM12878, using thirty MinION flow cells at six institutions. These native RNA reads had a median length of 771 bases, and a maximum aligned length of over 21,000 bases. Mitochondrial poly(A) reads provided an internal measure of read-length quality. We combined these long nanopore reads with higher accuracy short-reads and annotated GM12878 promoter regions to identify 33,984 plausible RNA isoforms. We describe strategies for assessing 3' poly(A) tail length, base modifications and transcript haplotypes.

Published
2019

236. Gastric emptying of oil and aqueous meal components in pancreatic insufficiency: effects of posture and on appetite

Author

Carney, Bernard I., Jones, Karen L., Horowitz, Michael, Sun, Wei Ming, Penagini, Roberto, and Meyer, James H.

Subjects
Gastroenterology -- Influence, Pancreatic insufficiency -- Research, Appetite -- Physiological aspects, Posture -- Physiological aspects, Biological sciences
Abstract

Pancreatic insufficiency affects gastric emptying of oil, intragastric distribution and satiation after a meal. This is confirmed by evaluating patients having cystic fibrosis and normal volunteers. In normal persons no difference in emptying of oil in various postures was found and they retained oil in the proximate stomach. Their hunger also decreased after a meal. Cystic fibrosis patients exhibited higher emptying in both postures, lower retention of oil in the proximate stomach and did not show less hunger after a meal.

Published
1995

238. Photochemical treatment of transition metal substituted disilanes, (eta5-C5H5)Fe(CO)2Si2Me4(C6H4X) (X = Cl, CF3, NMe2, OMe, H), including trapping of expelled silylene

Author

Jones, Karen L. and Pannell, Keith H.

Subjects
Transition metals -- Research, Photochemistry -- Methods, Silane -- Analysis, Rearrangements (Chemistry) -- Observations, Chemistry
Abstract

Photochemical treatment of transition metal substituted disilanes in inert hydrocarbon solvents results in the discharge of the SiMeAr and SiMe2 fragments to produce FpSiMe2Ar and FpSiMe3. Photolysis of Fp-disilanes induces some direct Si-Si cleavage in which fortuitous H2O plays a role. Siloxane materials are formed when SiMe2 reacts units CO in the presence of metal complexes.

Published
1993

245. Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit.

Author

Wu, Tongzhi, Rayner, Christopher K., Jones, Karen L., Horowitz, Michael, Feinle‐Bisset, Christine, Standfield, Scott D., Xie, Cong, Deacon, Carolyn F., Holst, Jens J., and Wewer Albrechtsen, Nicolai J.

Subjects
GLUCAGON, RADIOIMMUNOASSAY
Abstract

In our routine use of RIA for glucagon analysis, we began seeing unexpected plasma glucagon responses to oral and enteral glucose loads in both healthy humans and patients with type 2 diabetes, which differed markedly from responses seen in similar subjects in earlier studies. The relationships between the integrated glucagon response relative to baseline measured by Millipore radioimmunoassay (RIA) and Mercodia ELISA kits were evaluated by linear regression analysis (C and F). Our data also suggest that the RIA kit manufactured prior to the change of antibody for glucagon was acceptable for evaluation of circulating glucagon levels in clinical settings (although suppression by glucose was not always clearly shown, when compared with more sensitive assays11). [Extracted from the article]

Published
2022
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246. Nanopore native RNA sequencing of a human poly(A) transcriptome

Author

Workman, Rachael E., primary, Tang, Alison D., additional, Tang, Paul S., additional, Jain, Miten, additional, Tyson, John R., additional, Razaghi, Roham, additional, Zuzarte, Philip C., additional, Gilpatrick, Timothy, additional, Payne, Alexander, additional, Quick, Joshua, additional, Sadowski, Norah, additional, Holmes, Nadine, additional, de Jesus, Jaqueline Goes, additional, Jones, Karen L., additional, Soulette, Cameron M., additional, Snutch, Terrance P., additional, Loman, Nicholas, additional, Paten, Benedict, additional, Loose, Matthew, additional, Simpson, Jared T., additional, Olsen, Hugh E., additional, Brooks, Angela N., additional, Akeson, Mark, additional, and Timp, Winston, additional

Published
2019
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247. The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects

Author

Pham, Hung, primary, Holen, Iselin S., additional, Phillips, Liza K., additional, Hatzinikolas, Seva, additional, Huynh, Lian Q., additional, Wu, Tongzhi, additional, Hausken, Trygve, additional, Rayner, Christopher K., additional, Horowitz, Michael, additional, and Jones, Karen L., additional

Published
2019
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250. Nanopore native RNA sequencing of a human poly(A) transcriptome: RNA extraction, cDNA conversion and direct RNA and cDNA library preparation for Oxford Nanopore

Author

Workman, Rachael E., primary, Tang, Alison D., additional, Tang, Paul S., additional, Jain, Miten, additional, Tyson, John R., additional, Razaghi, Roham, additional, Zuzarte, Philip C., additional, Gilpatrick, Timothy, additional, Payne, Alexander, additional, Quick, Joshua, additional, Sadowski, Norah, additional, Holmes, Nadine, additional, Jesus, Jaqueline Goes de, additional, Jones, Karen L., additional, Snutch, Terrance P., additional, Loman, Nicholas, additional, Paten, Benedict, additional, Loose, Matthew, additional, Simpson, Jared T., additional, Olsen, Hugh E., additional, Brooks, Angela N., additional, Akeson, Mark, additional, and Timp, Winston, additional

Published
2019
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