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Abstract Background Partial Trisomy 11q syndrome (or Duplication 11q) has defined clinical features and is documented as a rare syndrome by National Organization of Rare Disorders (NORD). Deletion 1q44 (or Monosomy 1q44) is a well-defined syndrome, but there is controversy about the genes lying in 1q44 region, responsible for agenesis of the corpus callosum. We report a female child with the rare Partial Trisomy 11q syndrome and Deletion 1q44 syndrome. The genomic imbalance in the proband was used for molecular characterization of the critical genes in 1q44 region for agenesis of corpus callosum. Some genes in 11q14q25 may be responsible for laryngomalacia. Results We report a female child with dysmorphic features, microcephaly, growth retardation, seizures, acyanotic heart disease, and hand and foot deformities. She had agenesis of corpus callosum, laryngomalacia, anterior ectopic anus, esophageal reflux and respiratory distress. Chromosome analysis revealed a derivative chromosome 1. Her karyotype was 46,XX,der(1)t(1;11)(q44;q14)pat. The mother had a normal karyotype and the karyotype of the father was 46,XY,t(1;11)(q44;q14). SNP array analysis showed that the proband had a 54 Mb duplication of 11q14q25 and a 0.9 Mb deletion of the submicroscopic subtelomeric 1q44 region. Fluorescence Insitu Hybridisation confirmed the duplication of 11qter and deletion of 1qter. Conclusion Laryngomalacia or obstruction of the upper airway is the outcome of increased dosage of some genes due to Partial Trisomy 11q Syndrome. In association with other phenotypic features, agenesis of corpus callosum appears to be a landmark phenotype for Deletion 1q44 syndrome, the critical genes lying proximal to SMYD3 in 1q44 region.

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The study aimed to determine the more performance sheep between Jamuna basin indigenous and Muzaffarnagri cross breeds with respect to their morphometric, reproductive and productive traits for farmers' choice of Bangladesh. Farm visit, routine monitoring, spot observation and semi-structure questionnaire were used for field data collection. Morphometric traits like body weight (BWT), withers height (WH), heart girth (HG) and body length (BL) were studied both on matured rams and ewes of Jamuna basin indigenous and Muzaffarnagri cross breed sheep and scrotal circumference (SC) and testicular length (TL) on mature rams. Muzaffarnagri cross sheep had significantly higher body weight than Jamuna basin indigenous sheep. The ram traits were dominated over female except Jamuna basin indigenous ewes had higher body length than male. The age at first service (AFS), gestation length (GL), age at first lambing (AFL), lambing interval (LI) and post-partum interval (PPI) were found significantly shorter in Jamuna basin indigenous ewes than those of Muzaffarnagari cross breed ewes. The multiple births and number of female lambs were higher in Jamuna basin indigenous than those of Muzaffarnagari cross breed sheep. In reverse, single birth and number of male lambs were higher in Muzaffarnagari cross breed sheep than those of Jamuna basin indigenous sheep. The birth weight, 30 and 60 days weight, average daily gains at (0-30) and (30-60) days were significantly higher in Muzaffarnagari cross breed lambs than those of Jamuna basin indigenous lambs. Male lambs were dominated in weight and daily gain over female lambs in all age groups and breed difference were significant. Although Jamuna basin indigenous is comparatively more prolific in nature in reproductive traits but morphometric and productive features of Muzaffarnagari cross breed sheep may generate more money to fulfill the farmer's dream. [ABSTRACT FROM AUTHOR]

The cross-plane thermoelectric transport properties of La0.67Sr0.33MnO3 (LSMO)/LaMnO3 (LMO) oxide metal/semiconductor superlattices were investigated. The LSMO and LMO thin-film depositions were performed using pulsed laser deposition to achieve low resistivity constituent materials for LSMO/LMO superlattice heterostructures on (100)-strontium titanate substrates. X-ray diffraction and high-resolution reciprocal space mapping indicate that the superlattices are epitaxial and pseudomorphic. Cross-plane devices were fabricated by etching cylindrical pillar structures in superlattices using inductively, this coupled-plasma reactive-ion etching. The cross-plane electrical conductivity data for LSMO/LMO superlattices reveal a lowering of the effective barrier height to 223 meV as well as an increase in cross-plane conductivity by an order of magnitude compared to high resistivity superlattices. These results suggest that controlling the oxygen deficiency in the constituent materials enables modification of the effective barrier height and increases the cross-plane conductivity in oxide superlattices. The cross-plane LSMO/LMO superlattices showed a giant Seebeck coefficient of 2560 μV/K at 300 K that increases to 16 640 μV/K at 360 K. The giant increase in the Seebeck coefficient with temperature may include a collective contribution from the interplay of charge, spin current, and phonon drag. The low resistance oxide superlattices exhibited a room temperature cross-plane thermal conductivity of 0.92 W/m K, this indicating that the suppression of thermal conductivities due to the interfaces is preserved in both low and high resistivity superlattices. The high Seebeck coefficient, the order of magnitude improvement in cross-plane conductivity, and the low thermal conductivity in LSMO/LMO superlattices resulted in a two order of magnitude increase in cross-plane power factor and thermoelectric figure of merit (ZT), compared to the properties of superlattices with higher resistivity that were reported previously. The temperature dependence of the cross-plane power factor in low resistance superlattices suggests a direction for further investigations of the potential LSMO/LMO oxide superlattices for thermoelectric devices. [ABSTRACT FROM AUTHOR]

Lanthanum strontium manganate (La0.67Sr0.33MnO3, i.e., LSMO)/lanthanum manganate (LaMnO3, i.e., LMO) perovskite oxide metal/semiconductor superlattices were investigated as a potential p-type thermoelectric material. Growth was performed using pulsed laser deposition to achieve epitaxial LSMO (metal)/LMO (p-type semiconductor) superlattices on (100)-strontium titanate (STO) substrates. The magnitude of the in-plane Seebeck coefficient of LSMO thin films (<20 μV/K) is consistent with metallic behavior, while LMO thin films were p-type with a room temperature Seebeck coefficient of 140 μV/K. Thermal conductivity measurements via the photo-acoustic (PA) technique showed that LSMO/LMO superlattices exhibit a room temperature cross-plane thermal conductivity (0.89 W/m·K) that is significantly lower than the thermal conductivity of individual thin films of either LSMO (1.60 W/m·K) or LMO (1.29 W/m·K). The lower thermal conductivity of LSMO/LMO superlattices may help overcome one of the major limitations of oxides as thermoelectrics. In addition to a low cross-plane thermal conductivity, a high ZT requires a high power factor (S2σ). Cross-plane electrical transport measurements were carried out on cylindrical pillars etched in LSMO/LMO superlattices via inductively coupled plasma reactive ion etching. Cross-plane electrical resistivity data for LSMO/LMO superlattices showed a magnetic phase transition temperature (TP) or metal-semiconductor transition at ∼330 K, which is ∼80 K higher than the TP observed for in-plane resistivity of LSMO, LMO, or LSMO/LMO thin films. The room temperature cross-plane resistivity (ρc) was found to be greater than the in-plane resistivity by about three orders of magnitude. The magnitude and temperature dependence of the cross-plane conductivity of LSMO/LMO superlattices suggests the presence of a barrier with the effective barrier height of ∼300 meV. Although the magnitude of the cross-plane power factor is too low for thermoelectric applications by a factor of approximately 10-4-in part because the growth conditions chosen for this study yielded relatively high resistivity films-the temperature dependence of the resistivity and the potential for tuning the power factor by engineering strain, oxygen stoichiometry, and electronic band structure suggest that these epitaxial metal/semiconductor superlattices are deserving of further investigation. [ABSTRACT FROM AUTHOR]

Byline: Astik. Joshi, Alok. Joshi, Arun. Maseeh, Pankaj. Jha, Megha. Bhatt, Bhargava. Vyasa Background: The chronic debilitating conditions, i.e., diabetes and depression are associated with significant morbidity, mortality, and healthcare [...]

This article describes an actuator curve embedding (ACE) concept to model arbitrary lifting lines using body forces within large-eddy simulation (LES). The new method removes some inconsistencies in body-force projection of the actuator line model (ALM) commonly used to represent wind turbine blades in atmospheric boundary-layer simulations. The concept and algorithm of ACE are presented followed by selected results for various blade planform and tip shapes that signify both the predictive capability and the advantages of the ACE concept. Examples include an elliptic wing, the NREL Phase VI rotor in parked and rotating conditions, and the NREL 5-MW turbine. [ABSTRACT FROM AUTHOR]

The best Bangladeshi indigenous breeding rams (Wera breed) were selected by evaluating semen characteristics for using in future semen production and artificial insemination (AI) program. Of total rams (n=16), 12.5% (2/16) failed to show better performance and 87.5% (14/16) trained for semen collection. A total of 172 ejaculates were collected and evaluated during a period of 3 months. The mean frequency of semen collection was 12.3±7 and varied from 4 to 24. The quality of semen varied significantly among the rams (p<0.05). The selected 62.5% (10/16) best ram had the semen parameters ⩾ 0.5 ml volume, ⩾ 3 color (milky white), ⩾ 4 mass activity (vigorous movement with moderately rapid wave and eddies), ⩾ 80% sperm motility, ⩾ 90% sperm viability, ⩾ 2500 x 106 sperm/ml of concentration, ⩾ 85% sperm plasma membrane integrity, ⩾ 90% sperm acrosome integrity and ⩾ 80% normal sperm morphology. It was suggested that twice the number of ram may be selected before actual semen production and preservation. [ABSTRACT FROM AUTHOR]