2,896 results on '"J. Schwab"'
Search Results
202. Sternpunktbehandlung
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Adolf J. Schwab
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- 2022
203. Risk of Atrioventricular Block following Surgical Aortic Valve Replacement: A Computed Tomographic Analysis of Baseline Characteristics
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M. Claes, F. Pollari, I. Großmann, H. Mamdooh, J. Schwab, and T. Fischlein
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- 2022
204. Stromerzeugung aus Erneuerbaren Energien
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Adolf J. Schwab
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Gemas dem 1. Energiewirtschaftsgesetz (EnWG) aus dem Jahre 1935 erfolgte die Stromerzeugung in Deutschland vorrangig unter dem Gesichtspunkt minimaler Stromkosten bzw. -preise (s. a. 2.1.1 und 2.1.2). Der kostenoptimale Strommix aus fossil befeuerten Kraftwerken, Wasserkraftwerken und spater Kernkraftwerken richtete sich neben betrieblichen Erfordernissen nach den aktuellen Preisen bzw. Kosten fur die verschiedenen Primarenergietrager. Mit Ausnahme der Wasserkraft wurde die Nutzung Erneuerbarer Energien mittels Windradern und Solarzellen anfanglich vielfach belachelt.
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- 2022
205. Kurzschlussstromberechnung
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Adolf J. Schwab
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- 2022
206. Netzleittechnik
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Adolf J. Schwab
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- 2022
207. Smart Grids
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Adolf J. Schwab
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- 2022
208. Stromerzeugung in Kernkraftwerken
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Adolf J. Schwab
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Kernkraftwerke sind grundsatzlich auch thermische Kraftwerke bzw. Dampfkraftwerke. In ihnen wird jedoch die zum Verdampfen des Wassers benotigte Warme nicht durch Verbrennungsvorgange, sondern durch Freisetzen von Kernenergie in Kernreaktoren gewonnen. Ein Problem der Kernenergie ist ihre geteilte gesellschaftliche Akzeptanz angesichts mehrerer massiver Reaktorunfalle in anderen Landern und der Problematik der Endlagerung derzeit nur zwischengelagerter radioaktiver Abfalle.
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- 2022
209. Anhang
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Adolf J. Schwab
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- 2022
210. Verteilung elektrischer Energie vor der Energiewende
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Adolf J. Schwab
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- 2022
211. Vertical Profiles of Ozone Concentrations in the Lower Troposphere Downwind of New York City during LISTOS 2018-2019
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James J. Schwab, T. N. Knepp, Jie Zhang, Bhupal Shrestha, Margaret J. Schwab, Guillaume Gronoff, Maxim H. Couillard, Brennan Stutsrim, Cheng-Hsuan Lu, and Everette Joseph
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Pollution ,Shore ,Atmospheric Science ,geography ,Ozone ,geography.geographical_feature_category ,media_common.quotation_subject ,Low level jet ,Atmospheric sciences ,Troposphere ,chemistry.chemical_compound ,Geophysics ,chemistry ,Space and Planetary Science ,Sea breeze ,Earth and Planetary Sciences (miscellaneous) ,Environmental science ,Tropospheric ozone ,Long island sound ,media_common - Abstract
Twenty-six balloon-borne ozonesondes were launched near the north shore of central Long Island in the summers of 2018 and 2019 as part of the Long Island Sound Tropospheric Ozone Study (LISTOS). Wh...
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- 2021
212. Presynaptic inhibition in the striatum of the basal ganglia improves pattern classification and thus promotes superior goal selection
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David J Schwab and James C. eHouk
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Basal Ganglia ,Schizophrenia ,Striatum ,Pattern Classification ,presynaptic inhibition ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
This review article takes a multidisciplinary approach to understand how presynaptic inhibition in the striatum of the basal ganglia (BG) contributes to pattern classification and the selection of goals that control behavior. It is a difficult problem both because it is multidimensional and because it is has complex system dynamics. We focus on the striatum because, as the main site for input to the BG, it gets to decide what goals are important to consider.
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- 2015
- Full Text
- View/download PDF
213. Comparing Predictors of Complications After Anterior Cervical Diskectomy and Fusion, Total Disk Arthroplasty, and Combined Anterior Cervical Diskectomy and Fusion-Total Disk Arthroplasty With a Minimum 2-Year Follow-Up
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Sarah G Stroud, Cameron R. Moattari, Bassel G. Diebo, Jared M. Newman, Vincent Challier, Douglas A. Hollern, Virginie Lafage, George A. Beyer, John J. Kelly, Frank J. Schwab, Carl B. Paulino, Nicholas H. Post, Peter G. Passias, Ishaan Jain, Neil V. Shah, and Renaud Lafage
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Adult ,Male ,Reoperation ,Total Disc Replacement ,medicine.medical_specialty ,Time Factors ,Heart Diseases ,medicine.medical_treatment ,Logistic regression ,Patient Readmission ,Cohort Studies ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Cervical diskectomy ,medicine ,Humans ,Internal fixation ,Orthopedics and Sports Medicine ,030222 orthopedics ,business.industry ,030229 sport sciences ,Middle Aged ,medicine.disease ,Prosthesis Failure ,Pulmonary embolism ,Surgery ,Spinal Fusion ,medicine.anatomical_structure ,Cervical Vertebrae ,Female ,Implant ,Pulmonary Embolism ,Complication ,business ,Negative Results ,Diskectomy ,Follow-Up Studies ,Cohort study ,Cervical vertebrae - Abstract
INTRODUCTION Outcomes after anterior cervical diskectomy and fusion (ACDF) and cervical total disk arthroplasty (TDA) are satisfactory, but related morbidity and revision surgery rates are notable. This study sought to determine complication variations among ACDF, TDA, and combined ACDF-TDA as well as predictors of postoperative complications. METHODS Patients undergoing 1- to 2-level ACDF and/or TDA with at least a 2-year follow-up from 2009 to 2011 were identified from the Statewide Planning and Research Cooperative System database. Patient demographics, hospital-related parameters, mortality, and postoperative outcomes were compared, and their predictors were identified using multivariate logistic regression. RESULTS A total of 16,510 and 449 individuals underwent ACDF and cervical TDA, respectively, and 201 underwent ACDF-TDA. ACDF-TDA patients had the highest rates of cardiac complications and pulmonary embolism (PE) (P ≤ 0.006), whereas TDA patients had higher individual surgical and device/implant/internal fixation complications (P ≤ 0.025). ACDF-TDA patients experienced the lowest rate of revisions. Cervical TDA increased the odds of any surgical complications (OR = 2.5, P = 0.002), overall complications (OR = 1.57, P = 0.034), and revisions (OR = 2.29, P < 0.001). Deyo index predicted any medical/surgical complications (OR = 1.43 and 1.19, respectively). Female sex was associated with increased odds of readmission (OR 1.30, P < 0.001) but was protective against medical complications (OR = 0.81, P = 0.013). DISCUSSION Combined ACDF-TDA procedures were not associated with increases in 2-year individual or overall complications, readmissions, or revisions. LEVEL OF EVIDENCE Level 3-Therapeutic study.
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- 2019
214. Younger Patients Are Differentially Affected by Stiffness-Related Disability Following Adult Spinal Deformity Surgery
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Frank J. Schwab, Virginie Lafage, Justin S. Smith, David K. Hamilton, Han Jo Kim, Alan H. Daniels, Christopher I. Shaffrey, Peter G. Passias, Munish C. Gupta, Themistocles S. Protopsaltis, Robert Hart, Eric O. Klineberg, Wesley M. Durand, Michael P. Kelly, Doug Burton, Shay Bess, and Christopher P. Ames
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Adult ,Male ,medicine.medical_specialty ,Activities of daily living ,medicine.medical_treatment ,Scoliosis ,Lumbar vertebrae ,Disability Evaluation ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Lumbar ,Patient age ,Activities of Daily Living ,medicine ,Humans ,Range of Motion, Articular ,Aged ,Lumbar Vertebrae ,business.industry ,Age Factors ,Outcome measures ,Middle Aged ,medicine.disease ,Surgery ,Spinal Fusion ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Spinal fusion ,Spinal deformity ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
The Lumbar Stiffness Disability Index (LSDI) assesses impact of lumbar stiffness on activities of daily living. We hypothesized that patients60 years old would perceive greater lumbar stiffness-related functional limitation following fusion for adult spinal deformity.Patients completed the LSDI and Scoliosis Research Society 22 Questionnaire, Revised (SRS-22r) preoperatively and at 2 years postoperatively. The primary independent variable was patient age60 versus ≥60. Multivariable regression analyses were used.Analysis included 267 patients. Patients60 years old (51.3%) and ≥60 years old (48.7%) were evenly represented. In bivariable analysis, patients age60 exhibited lower LSDI at baseline versus patients age ≥60 (25.7 vs. 35.5, β -9.8, P0.0001), but a directionally smaller difference at 2 years (26.4 vs. 32.3, β -5.8, P = 0.0147). LSDI was associated with lower SRS-22r total score among both age groups at baseline and 2 years (all P0.0001); the association was stronger among patients age60 versus ≥60 at 2 years. LSDI was associated with SRS-22r satisfaction scores at 2 years among patients age60 (P0.0001), but not patients age ≥60 (P = 0.2250). The difference in SRS-22r satisfaction per unit LSDI between patients60 years old and ≥60 years old was significant (P = 0.0021).Among patients with adult spinal deformity managed operatively, higher LSDI was associated with inferior SRS-22r total score and satisfaction at 2 years postoperatively. The association between increased LSDI and worse patient-reported outcome measures was greater among patients age60 versus ≥60. Preoperative counseling is needed for patients age60 undergoing adult spinal deformity surgery regarding effects that lumbar stiffness may have on postoperative function and satisfaction.
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- 2019
215. The impact of sea-salt aerosols on particulate inorganic nitrogen deposition in the western Taiwan Strait region, China
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James J. Schwab, Shui-Ping Wu, Chung-Shin Yuan, Ning Zhang, Heng Zhu, Jin-Pei Yan, and Lu-Hong Dai
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inorganic chemicals ,Atmospheric Science ,Volatilisation ,food.ingredient ,010504 meteorology & atmospheric sciences ,Sea salt ,food and beverages ,010501 environmental sciences ,Particulates ,Atmospheric sciences ,01 natural sciences ,Aerosol ,chemistry.chemical_compound ,Deposition (aerosol physics) ,food ,Nitrate ,chemistry ,Environmental science ,Submarine pipeline ,Inorganic nitrogen ,0105 earth and related environmental sciences - Abstract
Sea-salt aerosol (SSA) has significant impact on the formation of secondary nitrate and its dry deposition in the coastal region. In this study, size-segregated aerosols were collected for water-soluble ions analysis in the coastal cities and sea cruises in the western Taiwan Strait of China from 2016 to 2017 to investigate the impact of SSA on particulate inorganic N deposition. The size distributions of NH4+ were characterized by a unimodal pattern peaking at 0.44–1.0 μm while NO3− exhibited typical bimodal distributions peaking at 0.44–1.0 μm and 2.5–10 μm. Furthermore, the fine mode peaks of NO3− became insignificant or disappeared in summer and fall due to the volatilization and dissociation of NH4NO3 at higher temperatures. Elevated sea-salt contributions in the largest size bin (>16 μm) during sea cruises were attributed to vessel induced wave breaking, while there was no peak for NO3− at this range due to its short atmospheric lifetime. Although the concentrations of particulate NH4+-N showed higher levels than those of NO3−-N for both coastal and marine aerosols, the dry deposition fluxes of the particulate NO3−-N were significant higher than those of the particulate NH4+-N due to their different size distributions. The contribution of SSA to particulate inorganic N deposition was estimated on average to be 20.33% and 36.91% in the coastal and offshore region, respectively, assuming all of the chlorine depletion was caused by the reaction between nitric acid and SSA in the coarse mode. In addition, dry deposition fluxes using constant deposition velocities for fine/coarse particles and NH4+/NO3− were higher than those using size-dependent dry deposition velocities. Considering the increasing human activities at the coastal urban zone in the western Taiwan Strait, the atmospheric N deposition could have an important ecological impact on the marine environment that is already under pressure from riverine inputs and urban waste discharges.
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- 2019
216. Predicting extended operative time and length of inpatient stay in cervical deformity corrective surgery
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Eric O. Klineberg, Breton Line, Gregory M. Mundis, Han Jo Kim, Shay Bess, Douglas C. Burton, Samantha R. Horn, Avery E. Brown, Christopher P. Ames, Katherine E. Pierce, Alan H. Daniels, Robert A. Hart, Cole Bortz, Themistocles S. Protopsaltis, Frank J. Schwab, Vedat Deviren, Virginie Lafage, Michael P. Kelly, Christopher I. Shaffrey, Peter G. Passias, Justin S. Smith, Haddy Alas, and Renaud Lafage
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Male ,medicine.medical_specialty ,Percentile ,medicine.medical_treatment ,Operative Time ,Corrective surgery ,Osteotomy ,Spinal Curvatures ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Physiology (medical) ,Cervical deformity ,medicine ,Humans ,Orthopedic Procedures ,Aged ,Retrospective Studies ,Inpatients ,Inpatient stay ,business.industry ,General Medicine ,Length of Stay ,Middle Aged ,Surgery ,Neurology ,030220 oncology & carcinogenesis ,Cervical Vertebrae ,Operative time ,Female ,Neurology (clinical) ,business ,Algorithms ,030217 neurology & neurosurgery - Abstract
It’s increasingly common for surgeons to operate on more challenging cases and higher risk patients, resulting in longer op-time and inpatient LOS. Factors predicting extended op-time and LOS for cervical deformity (CD) patients are understudied. This study identified predictors of extended op-time and length of stay (LOS) after CD-corrective surgery. CD patients with baseline (BL) radiographic data were included. Patients were stratified by extended LOS (ELOS; >75th percentile) and normal LOS (N-LOS; 12 h. A Conditional Variable Importance Table used non-replacement sampling set of Conditional Inference trees to identify influential factors. Mean comparison tests compared LOS and op-time for top factors. 142 surgical CD patients (61 yrs, 62%F, 8.2 levels fused). Op-time and LOS were 358 min and 7.2 days; 30% of patients experienced E-LOS (14 ± 13 days). Overlapping predictors of E-LOS and op-time included levels fused (>7 increased LOS 2.7 days; >5 increased op-time 96 min, P 38 kg/m2 increased LOS 8.1 days; >39 kg/m2 increased op-time 17 min), and osteotomy (LOS 2.0 days, op-time 62 min, P 42 mm increased LOS; >50 mm increased op-time, P @−0.9° increased LOS, >0.3° increased op-time, P
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- 2019
217. Decomposing the local arrow of time in interacting systems
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Christopher W. Lynn, Caroline M. Holmes, William Bialek, and David J. Schwab
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Neurons ,Statistical Mechanics (cond-mat.stat-mech) ,Entropy ,FOS: Biological sciences ,Quantitative Biology - Neurons and Cognition ,FOS: Physical sciences ,General Physics and Astronomy ,Neurons and Cognition (q-bio.NC) ,Condensed Matter - Statistical Mechanics - Abstract
We show that the evidence for a local arrow of time, which is equivalent to the entropy production in thermodynamic systems, can be decomposed. In a system with many degrees of freedom, there is a term that arises from the irreversible dynamics of the individual variables, and then a series of non--negative terms contributed by correlations among pairs, triplets, and higher--order combinations of variables. We illustrate this decomposition on simple models of noisy logical computations, and then apply it to the analysis of patterns of neural activity in the retina as it responds to complex dynamic visual scenes. We find that neural activity breaks detailed balance even when the visual inputs do not, and that this irreversibility arises primarily from interactions between pairs of neurons., 6 pages, 3 figures
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- 2021
218. A comparison of ultrasound echo intensity to magnetic resonance imaging as a metric for tongue fat evaluation
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Jason L Yu, Andrew Wiemken, Susan M Schultz, Brendan T Keenan, Chandra M Sehgal, and Richard J Schwab
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Sleep Apnea, Obstructive ,Tongue ,Physiology (medical) ,Animals ,Cattle ,Female ,Neurology (clinical) ,Sleep Disordered Breathing ,Magnetic Resonance Imaging ,Body Mass Index ,Ultrasonography - Abstract
Study Objectives Tongue fat is associated with obstructive sleep apnea (OSA). Magnetic resonance imaging (MRI) is the standard for quantifying tongue fat. Ultrasound echo intensity has been shown to correlate to the fat content in skeletal muscles but has yet to be studied in the tongue. The objective of this study is to evaluate the relationship between ultrasound echo intensity and tongue fat. Methods Ultrasound coronal cross-sections of ex-vivo cow tongues were recorded at baseline and following three 1 mL serial injections of fat into the tongue. In humans, adults with and without OSA had submental ultrasound coronal cross-sections of their posterior tongue. The average echo intensity of the tongues (cow/human) was calculated in ImageJ software. Head and neck MRIs were obtained on human subjects to quantify tongue fat volume. Echo intensity was compared to injected fat volume or MRI-derived tongue fat percentage. Results Echo intensity in cow tongues showed a positive correlation to injected fat volume (rho = 0.93, p < .001). In human subjects, echo intensity of the tongue base strongly correlated with MRI-calculated fat percentage for both the posterior tongue (rho = 0.95, p < .001) and entire tongue (rho = 0.62, p < .001). Larger tongue fat percentages (rho = 0.38, p = .001) and higher echo intensity (rho = 0.27, p = .024) were associated with more severe apnea-hypopnea index, adjusted for age, body mass index, sex, and race. Conclusions Ultrasound echo intensity is a viable surrogate measure for tongue fat volume and may provide a convenient modality to characterize tongue fat in OSA.
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- 2021
219. The Impact of Osteoporosis on Adverse Outcomes After Short Fusion for Degenerative Lumbar Disease
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Adam J, Wolfert, Alexander, Rompala, George A, Beyer, Neil V, Shah, Chibuokem P, Ikwuazom, David, Kim, Sharan T, Shah, Peter G, Passias, Virginie, Lafage, Frank J, Schwab, Carl B, Paulino, and Bassel G, Diebo
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Lumbar Vertebrae ,Postoperative Complications ,Spinal Fusion ,Lumbosacral Region ,Humans ,Osteoporosis ,Female ,Retrospective Studies - Abstract
Osteoporosis affects nearly 200 million individuals worldwide. There are little available data regarding outcomes in patients with osteoporosis who undergo short-segment lumbar fusion for degenerative disk disease (DDD). We sought to identify a relationship between osteoporosis and risk of adverse outcomes in patients with DDD undergoing short-segment lumbar fusion.Using the New York State Statewide Planning and Research Cooperative System, all patients with DDD who underwent 2- to 3-level lumbar fusion from 2009 through 2011 were identified. Patients with bone mineralization disorders and other systemic and endocrine disorders and surgical indications of trauma, systemic disease(s), and infection were excluded. Patients were stratified by the presence or absence of osteoporosis and compared for demographics, hospital-related parameters, and 2-year complications and revision surgeries. Multivariate binary logistic regression models were used to identify notable predictors of complications.A total of 29,028 patients (osteoporosis = 1,353 [4.7%], nonosteoporosis = 27,675 [95.3%]) were included. Patients with osteoporosis were older (66.9 vs 52.6 years), more often female (85.1% vs 48.4%), and White (82.8% vs 73.5%) (all P0.001). The Charlson/Deyo comorbidity index did not significantly differ between groups. Hospital lengths of stay and total charges were higher for patients with osteoporosis (4.9 vs 4.1 days; $74,484 vs $73,724; both P0.001). Medical complication rates were higher in patients with osteoporosis, including acute renal failure and deep-vein thrombosis (both P0.01). This cohort also had higher rates of implant-related (3.4% vs 1.9%) and wound (9.8% vs 5.9%) complications (both P0.01). Preoperative osteoporosis was strongly associated with 2-year medical and surgical complications (odds ratios, 1.6 and 1.7) as well as greater odds of revision surgeries (odds ratio, 1.3) (all P0.001).Patients with osteoporosis undergoing 2- to 3-level lumbar fusion for DDD were at higher risk of 2-year medical and surgical complications, especially implant-related and wound complications. These findings highlight the importance of rigorous preoperative metabolic workup and patients' optimization before spinal surgery.
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- 2021
220. Mechanical modifications of soft actuators for the use as a dynamic iris implant
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S. Martin, J. Schwab, P. Caballero Lopez, E. Benke, S. Reitelshofer, and J. Franke
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Prosthesis Implantation ,Visual Acuity ,Humans ,Iris ,Prostheses and Implants ,Aniridia - Abstract
Aniridia is a condition characterized by defects or absence of the iris. Since the eyes are a central point of attention in the human face, these deformities are often covered with cosmetic implants. However, patients suffer from the static pupil diameter of these implants, resulting in high light sensitivity or inadequate night vision. Therefore, we present a functional iris implant based on dielectric elastomer actuators. These electric drives are characterized by a silent and continuous adaptation as well as a small construction volume and a low heat emission. Since they normally exhibit in-plane uniaxial motion, this displacement must be focused to operate similarly to the iris sphincter. Therefore, we investigated possible mechanical modifications of the setups to generate a directional motion. The results of the study are presented and discussed.Clinical Relevance- The proposed system design enables the functional treatment of aniridia and other accidental iris defects. In addition, the system serves as a basis for later developments of e.g. functional lenses that allow focus adjustment.
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- 2021
221. Classification system for cervical spine deformity morphology: a validation study
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Philip K. Louie, Basel Sheikh Alshabab, Michael H. McCarthy, Sohrab Virk, James E. Dowdell, Michael E. Steinhaus, Francis Lovecchio, Andre M. Samuel, Kyle W. Morse, Frank J. Schwab, Todd J. Albert, Sheeraz A. Qureshi, Sravisht Iyer, Yoshihiro Katsuura, Russel C. Huang, Matthew E. Cunningham, Yu-Cheng Yao, Karen Weissmann, Renaud Lafage, Virginie Lafage, and Han Jo Kim
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Radiography ,Observer Variation ,Databases, Factual ,Cervical Vertebrae ,Humans ,Reproducibility of Results ,General Medicine ,Prospective Studies - Abstract
OBJECTIVE The objective of this study was to initially validate a recent morphological classification of cervical spine deformity pathology. METHODS The records of 10 patients for each of the 3 classification subgroups (flat neck, focal deformity, and cervicothoracic), as well as for 8 patients with coronal deformity only, were extracted from a prospective multicenter database of patients with cervical deformity (CD). A panel of 15 physicians of various training and professional levels (i.e., residents, fellows, and surgeons) categorized each patient into one of the 4 groups. The Fleiss kappa coefficient was utilized to evaluate intra- and interrater reliability. Accuracy, defined as properly selecting the main driver of deformity, was reported overall, by morphotype, and by reviewer experience. RESULTS The overall classification demonstrated a moderate to substantial agreement (round 1: interrater Fleiss kappa = 0.563, 95% CI 0.559–0.568; round 2: interrater Fleiss kappa = 0.612, 95% CI 0.606–0.619). Stratification by level of training demonstrated similar mean interrater coefficients (residents 0.547, fellows 0.600, surgeons 0.524). The mean intrarater score was 0.686 (range 0.531–0.823). A substantial agreement between rounds 1 and 2 was demonstrated in 81.8% of the raters, with a kappa score > 0.61. Stratification by level of training demonstrated similar mean intrarater coefficients (residents 0.715, fellows 0.640, surgeons 0.682). Of 570 possible questions, reviewers provided 419 correct answers (73.5%). When considering the true answer as being selected by at least one of the two main drivers of deformity, the overall accuracy increased to 86.0%. CONCLUSIONS This initial validation of a CD morphological classification system reiterates the importance of dynamic plain radiographs for the evaluation of patients with CD. The overall reliability of this CD morphological classification has been demonstrated. The overall accuracy of the classification system was not impacted by rater experience, demonstrating its simplicity.
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- 2021
222. Surgical Factors and Treatment Severity for Perioperative Complications Predict Hospital Length of Stay in Adult Spinal Deformity Surgery
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Hai V. Le, Joseph B. Wick, Renaud Lafage, Michael P. Kelly, Han Jo Kim, Munish C. Gupta, Shay Bess, Douglas C. Burton, Christopher P. Ames, Justin S. Smith, Christopher I. Shaffrey, Frank J. Schwab, Peter G. Passias, Themistocles S. Protopsaltis, Virginie Lafage, and Eric O. Klineberg
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Adult ,Postoperative Complications ,Quality of Life ,Humans ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Length of Stay ,Hospitals ,Retrospective Studies - Abstract
Retrospective review of prospectively collected multicenter registry data.The aim of this study was to determine whether surgical variables and complications as graded by treatment severity impact postoperative hospital length of stay (LOS).Surgical treatment can substantially improve quality of life for patients with adult spinal deformity (ASD). However, surgical treatment is associated with high complication rates, which may impact hospital LOS. Classifying complications by severity of subsequent treatment may allow surgeons to better understand complications and predict their impact on important outcome metrics, including LOS.Patients enrolled in a multicenter, prospectively enrolled database for ASD were assessed for study inclusion. Complications were graded based on intervention severity. Associations between LOS, complication intervention severity, and surgical variables (fusion length, use of interbody fusion, use of major osteotomy, primary versus revision surgery, same day vs. staged surgery, and surgical approach), were assessed. Two multivariate regression models were constructed to assess for independent associations with LOS.Of 1183 patients meeting inclusion criteria, 708 did not and 475 did experience a perioperative complication during their index hospitalization, with 660 and 436 included in the final cohorts, respectively. Among those with complications, intervention severities included 14.9% with no intervention, 68.6% with minor, 8.9% with moderate, and 7.6% with severe interventions. Multivariate regression modeling demonstrated that length of posterior fusion, use of major osteotomy, staged surgery, and severity of intervention for complications were significantly associated with LOS.Careful selection of surgical factors may help reduce hospital LOS following surgery for ASD. Classification of complications by treatment severity can help surgeons better understand and predict the implications of complications, in turn assisting with surgical planning and patient counseling.Level of Evidence: 4.
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- 2021
223. Epidemiology and infection control of carbapenem resistant Acinetobacter baumannii and Klebsiella pneumoniae at a German university hospital: a retrospective study of 5 years (2015–2019)
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Patrick Chhatwal, Dirk Schlüter, Frank J. Schwab, Stefan Ziesing, Ella Ebadi, Claas Baier, Nicolas Simon, Franz-Christoph Bange, Ralf-Peter Vonberg, and Svetlana Gerbel
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Acinetobacter baumannii ,medicine.medical_specialty ,Epidemiology ,Klebsiella pneumoniae ,Infectious and parasitic diseases ,RC109-216 ,Hospitals, University ,Medical microbiology ,Internal medicine ,medicine ,Humans ,Infection control ,Retrospective Studies ,Infection Control ,biology ,business.industry ,Research ,Incidence (epidemiology) ,Outbreak ,Retrospective cohort study ,biology.organism_classification ,Anti-Bacterial Agents ,Klebsiella Infections ,Infectious Diseases ,Carbapenems ,Screening ,Carbapenem resistant ,business - Abstract
Background Carbapenem resistant (CR) Klebsiella pneumoniae (Kp) and Acinetobacter baumannii (Ab) are emerging multidrug resistant bacteria with very limited treatment options in case of infection. Both are well-known causes of nosocomial infections and outbreaks in healthcare facilities. Methods A retrospective study was conducted to investigate the epidemiology of inpatients with CR Kp and CR Ab in a 1500-bed German university hospital from 2015 to 2019. We present our infection control concept including a weekly microbiologic screening for patients who shared the ward with a CR Kp or CR Ab index patient. Results Within 5 years, 141 CR Kp and 60 CR Ab cases were hospitalized corresponding to 118 unique patients (74 patients with CR Kp, 39 patients with CR Ab and 5 patients with both CR Ab and CR Kp). The mean incidence was 0.045 (CR Kp) and 0.019 (CR Ab) per 100 inpatient cases, respectively. Nosocomial acquisition occurred in 53 cases (37.6%) of the CR Kp group and in 12 cases (20.0%) of the CR Ab group. Clinical infection occurred in 24 cases (17.0%) of the CR Kp group and in 21 cases (35.0%) of the CR Ab group. 14 cases (9.9%) of the CR Kp group and 29 cases (48.3%) of the CR Ab group had a history of a hospital stay abroad within 12 months prior to admission to our hospital. The weekly microbiologic screening revealed 4 CR Kp cases caused by nosocomial transmission that would have been missed without repetitive screening. Conclusions CR Kp and CR Ab cases occurred infrequently. A history of a hospital stay abroad, particularly in the CR Ab group, warrants pre-emptive infection control measures. The weekly microbiologic screening needs further evaluation in terms of its efficiency.
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- 2021
224. Improvement and International Validation of the Predictive Probability of the Patient Demographics, Radiographic Index, and Surgical Invasiveness for Mechanical Failure (PRISM) Model for Preventive Procedures in Adult Spinal Deformity Surgery
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Kota Watanabe, Narihito Nagoshi, Osahiko Tsuji, R. Shay Bess, Morio Matsumoto, Christopher I. Shaffrey, Masaya Nakamura, Satoshi Suzuki, Mitsuru Yagi, Frank J. Schwab, Virginie Lafage, Nori Satoshi, Naobumi Hosogane, Justin S. Smith, Yohei Takahashi, and Christopher P. Ames
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Adult ,Male ,medicine.medical_specialty ,genetic structures ,Patient demographics ,Radiography ,Logistic regression ,Neurosurgical Procedures ,Cohort Studies ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Aged ,Demography ,Probability ,Retrospective Studies ,business.industry ,External validation ,Mechanical failure ,Middle Aged ,Surgery ,Spinal Fusion ,Cohort ,Spinal deformity ,Female ,Neurology (clinical) ,Prism ,business - Abstract
This is an international multicenter retrospective review of 219 surgically treated consecutive adult spinal deformity (ASD) patients who had a minimum of five fused segments, completed a 2-year follow-up.The purpose of this study was to add the indices of preventive procedures to improve and to validate the predictive probability of the PRISM (patient demographics, radiographic index, and surgical invasiveness for mechanical failure) for mechanical failure (MF) following ASD surgery.The PRISM was developed from the data of 321 ASD patients, which stratified the risk of MF from six types of risk.Data from 136 Japanese ASD patients (age 49 ± 21 yr, 88% female) were used to develop PRISM2, and data from 83 US ASD patients (age 58 ± 12 yr, 86% female) were used for the external validation. We analyzed the associations between three preventive procedures (UIV+1 tethering [TH], teriparatide [TP], and multirod [MR]) and MF by multivariate logistic regression analysis (MRA). The values for the nearest integer of the β of the procedures were added to the six indices of the original PRISM to establish the PRISM2. The discriminative ability of the PRISM/ PRISM2 for MF was evaluated using the area under the receiver operating characteristic curve (AUC) and the precision-recall (PR) curve. The Cochran-Armitage test was used to analyze the trend between PRISM/PRISM2 scores and MF.MF developed in 25% (34 cases). The β values for the preventive procedures calculated by MRA were TH: -2.5, TP: -3.0, and MR: -2.1. The Cochran-Armitage test showed an excellent trend between MF and PRISM/2. The diagnostic ability was superior for the PRISM2 compared with the PRISM (PRISM2; AUC = 0.94 [0.90-0.98], PRISM; AUC = 0.87 [0.81-0.93], difference = -0.07 [-0.11 to -0.03], P 0.01). The AUC of the PRISM2 was 0.70 [0.59-0.81, P 0.01] in the US patient cohort.We refined the PRISM by adding preventive procedures to the risk indices. Further validation and adjustment in a large different patient cohorts may improve the predictive probability of PRISM2.Level of Evidence: 3.
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- 2021
225. Comparing and Contrasting the Clinical Utility of Sagittal Spine Alignment Classification Frameworks: Roussouly Versus SRS-Schwab
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Cole Bortz, Bassel G. Diebo, Christopher I. Shaffrey, Oscar Krol, Virginie Lafage, Shay Bess, Daniel M. Sciubba, Lara Passfall, Andrew J. Schoenfeld, Nicholas Kummer, Justin S. Smith, Katherine E. Pierce, Eric O. Klineberg, Christopher P. Ames, Douglas C. Burton, Frank J. Schwab, Breton Line, Peter G. Passias, Munish C. Gupta, Renaud Lafage, and Richard A. Hostin
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Adult ,Univariate analysis ,medicine.medical_specialty ,business.industry ,Radiography ,Minimal clinically important difference ,Background data ,Retrospective cohort study ,Surgical planning ,Sagittal plane ,Spine ,medicine.anatomical_structure ,Scoliosis ,Internal medicine ,Spinal deformity ,Quality of Life ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Patient Reported Outcome Measures ,business ,Retrospective Studies - Abstract
Study design Retrospective cohort study of a prospectively collected database. Objective To compare clinical utility of two common classification systems for ASD and determine whether both should be considered in surgical planning to improve patient outcomes. Summary of background data Surgical restoration of appropriate Roussouly classification shape or SRS-Schwab adult spinal deformity (ASD) classification may improve outcomes. Methods ASD patients with pre- and 2-year postop (2Y) radiographic/HRQL data were grouped by "theoretical" and "current" Roussouly type. Univariate analyses assessed outcomes of patients who mismatched Roussouly types at both pre- and 2Y intervals (Mismatched) and those of preoperative mismatched patients who matched at 2-years (Matched). Subanalysis assessed outcomes of patients who improved in Schwab modifiers, and patients who both improved in both Schwab modifiers and matched Roussouly type by 2Y. Results Included: 515 ASD patients (59 ± 14yrs, 80%F). Preoperative breakdown of "current" Roussouly types: Type 1 (10%), 2 (54%), 3 (24%), and 4 (12%). Matched and Mismatched groups did not differ in rates of reaching MCID for any HRQL metrics by 2Y (all p > 0.10). Reoperation, PJK, and complications did not differ between Matched and Mismatched (all p > 0.10), but Roussouly Matched patients had toward lower rates of instrumentation failure (17.2% vs 24.8%, p=0.038). By 2Y, 28% of patients improved in PT Schwab modifier, 37% in SVA, and 46% in PI-LL. Patients who both Matched Roussouly at 2Y and improved in all Schwab modifiers met MCID for ODI and SRS Activity at higher rates than patients who did not. Conclusions Isolated restoration per the Roussouly system was not associated with superior outcomes. Patients who both matched Roussouly type and improved in Schwab modifiers had superior patient-reported outcomes at 2-years. Concurrent consideration of both systems may offer utility in establishing optimal realignment goals.Level of Evidence: 3.
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- 2021
226. Selected Mechanistic Aspects of Viral Inactivation by Peracetic Acid
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Kellogg J. Schwab, Joseph G. Jacangelo, Bradley W. Schmitz, and Hanwei Wang
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chemistry.chemical_classification ,Methionine ,viruses ,Tryptophan ,Cystine ,General Chemistry ,biochemical phenomena, metabolism, and nutrition ,Amino acid ,Disinfection ,chemistry.chemical_compound ,Mice ,chemistry ,Biochemistry ,Capsid ,Peracetic acid ,Environmental Chemistry ,Animals ,Virus Inactivation ,Nucleotide ,Peracetic Acid ,Cysteine ,Disinfectants ,Levivirus - Abstract
Peracetic acid (PAA) is an alternative to traditional wastewater disinfection as it has a high oxidation potential without producing chlorinated disinfection byproducts. Reports have shown the effectiveness of PAA to reduce waterborne viruses, but the mechanism of inactivation is understudied. This study evaluated PAA consumption by amino acids and nucleotides that are the building blocks of both viral capsids and genomes. Cysteine (>1.7 min-1) and methionine (>1.2 min-1) rapidly consumed PAA, while cystine (1.9 × 10-2 min-1) and tryptophan (1.4 × 10-4 min-1) reactions occurred at a slower rate. All other amino acids and nucleotides did not react significantly (p < 0.05) with PAA during experiments. Also, PAA treatment did not result in significant (p < 0.05) reductions of purified RNA from MS2 bacteriophage and murine norovirus. Data in this study suggest that PAA effectively inactivates viruses by targeting susceptible amino acids on capsid proteins and does not readily damage viral genomes. Knowledge of virus capsid structures and protein compositions can be used to qualitatively predict the relative resistance or susceptibility of virus types to PAA. Capsid structures containing a higher total number of target amino acids may be more susceptible to PAA reactions that damage structural integrity resulting in inactivation.
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- 2021
227. Adult Spinal Deformity Surgery Is Associated with Increased Productivity and Decreased Absenteeism From Work and School
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Frank J. Schwab, Wesley M. Durand, Jeffrey L. Gum, D. Kojo Hamilton, Michael Kelly, Virginie Lafage, Christopher I. Shaffrey, Alex Soroceanu, Khaled M. Kebaish, Christopher P. Ames, Han Jo Kim, Jacob Babu, Gregory M. Mundis, Robert A. Hart, Doug Burton, Peter G. Passias, Munish C. Gupta, Shay Bess, Robert K. Eastlack, Renaud Lafage, Justin S. Smith, Richard A. Hostin, Alan H. Daniels, Eric O. Klineberg, and Themistocles S. Protopsaltis
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Adult ,medicine.medical_specialty ,Schools ,business.industry ,medicine.medical_treatment ,Repeated measures design ,Retrospective cohort study ,Surgery ,Quality of life ,Spinal fusion ,Cohort ,Absenteeism ,Deformity ,Lordosis ,Quality of Life ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Neurology (clinical) ,medicine.symptom ,business ,Productivity ,Follow-Up Studies ,Retrospective Studies - Abstract
Retrospective cohort study.We hypothesized that adult spinal deformity (ASD) surgery would be associated with improved work- and school-related productivity, as well as decreased rates of absenteeism.ASD patients experience markedly decreased health-related quality of life along many dimensions.Only patients eligible for 2-year follow-up were included, and those with a history of previous spinal fusion were excluded. The primary outcome measures in this study were Scoliosis Research Society-22r score (SRS-22r) questions 9 and 17. A repeated measures mixed linear regression was used to analyze responses over time among patients managed operatively (OP) versus nonoperatively (NON-OP).In total, 1188 patients were analyzed. 66.6% were managed operatively. At baseline, the mean percentage of activity at work/school was 56.4% (standard deviation [SD] 35.4%), and the mean days off from work/school over the past 90 days was 1.6 (SD 1.8). Patients undergoing ASD surgery exhibited an 18.1% absolute increase in work/school productivity at 2-year follow-up versus baseline (P 0.0001), while no significant change was observed for the nonoperative cohort (P 0.5). Similarly, the OP cohort experienced 1.1 fewer absent days over the past 90 days at 2 years versus baseline (P 0.0001), while the NON-OP cohort showed no such difference (P 0.3). These differences were largely preserved after stratifying by baseline employment status, age group, sagittal vertical axis (SVA), pelvic incidence minus lumbar lordosis (PI-LL), and deformity curve type.ASD patients managed operatively exhibited an average increase in work/school productivity of 18.1% and decreased absenteeism of 1.1 per 90 days at 2-year follow-up, while patients managed nonoperatively did not exhibit change from baseline. Given the age distribution of patients in this study, these findings should be interpreted as pertaining primarily to obligations at work or within the home. Further study of the direct and indirect economic benefits of ASD surgery to patients is warranted.Level of Evidence: 3.
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- 2021
228. Insights into factors affecting size-segregated nitrate formation in a coastal city through measurements of dual isotopes
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Xiang Li, Shui-Ping Wu, Jie Zhang, and James J. Schwab
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Atmospheric Science ,General Environmental Science - Published
- 2022
229. Comparative investigation of PFAS adsorption onto activated carbon and anion exchange resins during long-term operation of a pilot treatment plant
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Steven J. Chow, Henry C. Croll, Nadezda Ojeda, Jamie Klamerus, Ryan Capelle, Joan Oppenheimer, Joseph G. Jacangelo, Kellogg J. Schwab, and Carsten Prasse
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Fluorocarbons ,Environmental Engineering ,Charcoal ,Ecological Modeling ,Humans ,Adsorption ,Pollution ,Waste Management and Disposal ,Anion Exchange Resins ,Water Pollutants, Chemical ,Water Purification ,Water Science and Technology ,Civil and Structural Engineering - Abstract
Widespread contamination of groundwater with per- and polyfluoroalkyl substances (PFAS) has required drinking water producers to quickly adopt practical and efficacious treatments to limit human exposure and deleterious health outcomes. This pilot-scale study comparatively investigated PFAS adsorption behaviors in granular activated carbon (GAC) and two strong-base gel anion exchange resin (AER) columns operated in parallel over a 441-day period to treat contaminated groundwater dominated by short-chain perfluorocarboxylic acids (PFCA). Highly-resolved breakthrough profiles of homologous series of 2-8 CF
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- 2022
230. A Hybrid Lagrangian–Eulerian Particle Model for Ecosystem Simulation
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Pengfei Xue, David J Schwab, Xing Zhou, Chenfu Huang, Ryan Kibler, and Xinyu Ye
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property-carrying particle model ,coupled models ,ecosystem simulation ,biophysical modeling ,Sandusky Bay ,Great Lakes ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
Current numerical methods for simulating biophysical processes in aquatic environments are typically constructed in a grid-based Eulerian framework or as an individual-based model in a particle-based Lagrangian framework. Often, the biogeochemical processes and physical (hydrodynamic) processes occur at different time and space scales, and changes in biological processes do not affect the hydrodynamic conditions. Therefore, it is possible to develop an alternative strategy to grid-based approaches for linking hydrodynamic and biogeochemical models that can significantly improve computational efficiency for this type of linked biophysical model. In this work, we utilize a new technique that links hydrodynamic effects and biological processes through a property-carrying particle model (PCPM) in a Lagrangian/Eulerian framework. The model is tested in idealized cases and its utility is demonstrated in a practical application to Sandusky Bay. Results show the integration of Lagrangian and Eulerian approaches allows for a natural coupling of mass transport (represented by particle movements and random walk) and biological processes in water columns which is described by a nutrient-phytoplankton-zooplankton-detritus (NPZD) biological model. This method is far more efficient than traditional tracer-based Eulerian biophysical models for 3-D simulation, particularly for a large domain and/or ensemble simulations.
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- 2018
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231. Experimental Implementation of Dynamic Access Ordering.
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Sally A. McKee, Robert H. Klenke, Andrew J. Schwab, William A. Wulf, Steven A. Moyer, James H. Aylor, and Charles Y. Hitchcock
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- 1994
232. Re-validation and adaptation of the Menstrual Practice Needs Scale to measure the menstrual experiences of adult women working in Mukono District, Uganda
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Julie Hennegan, Justine N. Bukenya, Simon P.S. Kibira, Petranilla Nakamya, Fredrick Edward Makumbi, Natalie Exum, and Kellogg J. Schwab
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bepress|Social and Behavioral Sciences|Other Social and Behavioral Sciences ,bepress|Social and Behavioral Sciences ,SocArXiv|Social and Behavioral Sciences|Other Social and Behavioral Sciences ,SocArXiv|Social and Behavioral Sciences - Abstract
Objectives. The Menstrual Practice Needs Scale (MPNS) is a comprehensive measure of menstrual self-care experience including access to sufficient, comfortable absorbents, supportive spaces for managing menstruation and for disposal and laundering of used materials. It addresses a critical measurement gap to improve quantitative menstrual health research. The scale was validated in a population of adolescent schoolgirls. This study appraises its performance among adult women.Methods. Seven cognitive interviews provided insights into the interpretability and acceptability of scale items. A cross sectional survey of 525 working women who had menstruated in the past six months (including 435 working in markets, 45 in schools and 45 working in health care facilities) in Mukono District, Uganda was used to test the dimensionality, reliability, and validity of the measure. Results. The 36 scale items were well understood by the study population. Dimensionality was tested for the 28 items relevant to women disposing of menstrual materials and 32 items relevant to those washing and reusing materials. The original subscale structure fit with the data, however fell short of recommended thresholds for those disposing of materials (RMSEA=0.069; CFI=0.840; TLI=0.824). An alternative sub-scale structure was an acceptable fit for those disposing (RMSEA = 0.051; CFI=0.911; TLI=0.897) and reusing materials (RMSEA=0.053; CFI=0.915; TLI=0.904). MPNS total and sub-scale scores demonstrated acceptable internal consistency. Higher scores reflected more positive menstrual experiences and were associated with greater wellbeing (total score r=0.24, p
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- 2021
233. The impact of lumbar alignment targets on mechanical complications after adult lumbar scoliosis surgery
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Brian L, Dial, Jeffrey M, Hills, Justin S, Smith, Juan Pablo, Sardi, Bruno, Lazaro, Christopher I, Shaffrey, Shay, Bess, Frank J, Schwab, Virginie, Lafage, Renaud, Lafage, Michael P, Kelly, and Keith H, Bridwell
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Adult ,Lumbar Vertebrae ,Postoperative Complications ,Spinal Fusion ,Scoliosis ,Lordosis ,Animals ,Humans ,Kyphosis ,Retrospective Studies - Abstract
The purpose of this study was to determine the discriminatory ability of age-adjusted alignment offset and the global alignment and proportion (GAP) score parameters to predict postoperative mechanical complications.Surgical patients from the Adult Symptomatic Lumbar Scoliosis cohort were reviewed at 2 year follow up. Age-adjusted alignment offsets and GAP parameters were calculated for each patient. A series of nonlinear logistic regression models were fit, and the odds of mechanical complications were calculated. The discriminatory ability of the GAP score, GAP score parameters, and age-adjusted alignment offsets were determined plotting receiver operative characteristic (ROC) with the C statistic (AUC).A total of 165 patients were included. A total of 49 mechanical complications occurred in 41 patients (21 proximal junctional kyphosis and 28 pseudoarthrosis). The GAP score had no discriminatory ability in this cohort. Relative lumbar lordosis 15 degrees greater than ideal lumbar lordosis was associated with greater mechanical complications. A lumbar distribution index of 90% was associated with fewer mechanical complications compared to a lumbar distribution index of 65%. Age-adjusted offset alignment targets had no discriminatory ability to predict mechanical complications.Radiographic alignment targets using either age-adjusted alignment target offset or GAP score parameters had minimal ability to predict mechanical complications in isolation. Mechanical complications following adult spinal deformity surgery are complex, and patient factors play a critical role. Clinical trial registeration This study was registered at ClinicalTrials.gov (number NCT00854828) in March 2009.
- Published
- 2021
234. Increasing Cost Efficiency in Adult Spinal Deformity Surgery: Identifying Predictors of Lower Total Costs
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Hamid Hassanzadeh, Justin D. Smith, Richard A. Hostin, Renaud Lafage, Haddy Alas, Peter G. Passias, Cole Bortz, Lawal Labaran, Eric O. Klineberg, Christopher I. Shaffrey, Brian J. Neuman, Frank J. Schwab, Virginie Lafage, Robert Hart, Waleed Ahmad, Breton Line, Avery E. Brown, Douglas C. Burton, Katherine E. Pierce, Jeffrey L. Gum, Sara Naessig, Khaled M. Kebaish, Christopher P. Ames, and Shay Bess
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Adult ,medicine.medical_specialty ,Cost efficiency ,Total cost ,business.industry ,Significant difference ,Retrospective cohort study ,Surgery ,Quality-adjusted life year ,Scoliosis ,Deformity ,Spinal deformity ,Quality of Life ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Neurology (clinical) ,Kyphosis ,Prospective Studies ,medicine.symptom ,business ,Depression (differential diagnoses) ,Retrospective Studies - Abstract
Retrospective study of a prospective multicenter database.The purpose of this study was to identify predictors of lower total surgery costs at 3 years for adult spinal deformity (ASD) patients.ASD surgery involves complex deformity correction.Inclusion criteria: surgical ASD (scoliosis ≥20°, sagittal vertical axis [SVA] ≥5 cm, pelvic tilt ≥25°, or thoracic kyphosis ≥60°) patients18 years. Total costs for surgery were calculated using the PearlDiver database. Cost per quality-adjusted life year was assessed. A Conditional Variable Importance Table used nonreplacement sampling set of 20,000 Conditional Inference trees to identify top factors associated with lower cost surgery for low (LSVA), moderate (MSVA), and high (HSVA) SRS Schwab SVA grades.Three hundred sixtee of 322 ASD patients met inclusion criteria. At 3-year follow up, the potential cost of ASD surgery ranged from $57,606.88 to $116,312.54. The average costs of surgery at 3 years was found to be $72,947.87, with no significant difference in costs between deformity groups (P 0.05). There were 152 LSVA patients, 53 MSVA patients, and 111 HSVA patients. For all patients, the top predictors of lower costs were frailty scores0.19, baseline (BL) SRS Activity1.5, BL Oswestry Disability Index50 (all P 0.05). For LSVA patients, no history of osteoporosis, SRS Activity scores1.5, age64, were the top predictors of lower costs (all P 0.05). Among MSVA patients, ASD invasiveness scores94.16, no past history of cancer, and frailty scores0.3 trended toward lower total costs (P = 0.071, P = 0.210). For HSVA, no history of smoking and body mass index27.8 trended toward lower costs (both P = 0.060).ASD surgery has the potential for improved cost efficiency, as costs ranged from $57,606.88 to $116,312.54. Predictors of lower costs included higher BL SRS activity, decreased frailty, and not having depression. Additionally, predictors of lower costs were identified for different BL deformity profiles, allowing for the optimization of cost efficiency for all patients.Level of Evidence: 3.
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- 2021
235. Does Achieving Global Spinal Alignment Lead to Higher Patient Satisfaction and Lower Disability in Adult Spinal Deformity?
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Douglas C. Burton, Gregory M. Mundis, Eric O. Klineberg, Han Jo Kim, Robert K. Eastlack, Frank J. Schwab, Christopher I. Shaffrey, Shay Bess, Christopher P. Ames, Virginie Lafage, Justin S. Smith, Basel Sheikh Alshabab, Renaud Lafage, and Munish C. Gupta
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Adult ,Male ,Multivariate statistics ,medicine.medical_specialty ,Multivariate analysis ,Pelvis ,Patient satisfaction ,Deformity ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Retrospective Studies ,business.industry ,Sagittal plane ,Spine ,medicine.anatomical_structure ,Clavicle ,Patient Satisfaction ,Coronal plane ,Cohort ,Physical therapy ,Quality of Life ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
STUDY DESIGN Multicenter retrospective review of prospective database. OBJECTIVE The aim of this study was to investigate potential associations between postoperative alignment and satisfaction. SUMMARY OF BACKGROUND DATA Achieving high satisfaction is the main goal of any treatment, including adult spinal deformity (ASD) surgery. Despite being one of the key elements, literature is sparse regarding postoperative factors influencing patient satisfaction. METHODS ASD patients with 2-year follow-up were retrospectively reviewed. Patients without revision after the index procedure were stratified according to deformity type: sagittal (T1 pelvic angle >22°), coronal (C7 plumb line [C7PL] >5 cm or MaxCobb >50°), or mixed. Bivariate correlation between satisfaction and postoperative data was conducted on the entire cohort as well as by type of preoperative deformity. Multivariate regression controlling for pre-op alignment and demographic information was used to identify independent predictors of 2Y satisfaction. RESULTS A total of 509 patients were included in the analysis (58.7 ± 14.8, 80% females). The quality of life significantly improved between pre- and 2-year (ΔOswestry Disability Index [ODI]: 17.6, p
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- 2021
236. Solubility of aerosol minor and trace elements in Xiamen Island, Southeast China: Size distribution, health risk and dry deposition
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Shui-Ping, Wu, Xiang, Li, Si-Han, Xiao, Jie, Zhang, and James J, Schwab
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Adult ,Aerosols ,Air Pollutants ,China ,Environmental Engineering ,Pollution ,Trace Elements ,Solubility ,Carcinogens ,Humans ,Environmental Chemistry ,Particle Size ,Child ,Waste Management and Disposal ,Environmental Monitoring - Abstract
Aerosol element solubility is essential to evaluate the damage to the environment and human health. In this work, the size distribution of total and soluble elements in eight particle size ranges with diameter0.25, 0.25-0.44, 0.44-1.0, 1.0-1.4, 1.4-2.5, 2.5-10, 10-16 and16 μm was investigated in Xiamen Island, southeast China from March 2018 to June 2020. The results showed that both total and soluble elements exhibited significant size dependence without obvious seasonal variations, and their relative contributions to PM
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- 2022
237. Growth and foraging behavior of hatchery propagated long-spined sea urchins, Diadema antillarum: Implications for aquaculture and restocking
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Md Mahbubul Hassan, Aaron R. Pilnick, Alex M. Petrosino, Jacob Harpring, Chloe J. Schwab, Keri L. O’Neil, and Joshua T. Patterson
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Animal Science and Zoology ,Aquatic Science - Published
- 2022
238. P101. Can AI identify patterns of complex adult spinal deformity with distinct perioperative outcomes?
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Renaud Lafage, Mitchell Stephen Fourman, Shay Bess, Douglas C. Burton, Alan H Daniels, Munish C Gupta, Richard A. Hostin, Khaled M. Kebaish, Christopher P. Ames, Michael P. Kelly, Han Jo Kim, Eric O. Klineberg, Lawrence G. Lenke, Stephen J. Lewis, Peter G Passias, Themistocles S Protopsaltis, Christopher I. Shaffrey, Frank J. Schwab, Virginie Lafage, null International Spine Study Group, and Justin S. Smith
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
239. 167. Neurologic outcomes of adult spinal deformity patients with baseline preoperative lower extremity weakness: will they improve following surgery?
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Fthimnir Hassan, Lawrence G. Lenke, Douglas C. Burton, Alan H. Daniels, Munish C. Gupta, Richard A. Hostin, Khaled M. Kebaish, Michael P. Kelly, Han Jo Kim, Eric O. Klineberg, Stephen J. Lewis, Peter G. Passias, Themistocles S. Protopsaltis, Frank J. Schwab, Christopher I. Shaffrey, Justin S. Smith, Breton Line, Virginie Lafage, Shay Bess, null International Spine Study Group, and Renaud Lafage
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
240. 31. Quantifying the contribution of lower limb compensation to upright posture: what happens if ASD patients do not compensate?
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Renaud Lafage, Jonathan Elysee, Shay Bess, Douglas C. Burton, Alan H. Daniels, Bassel G. Diebo, Munish C. Gupta, Richard A. Hostin, Khaled M. Kebaish, Michael P. Kelly, Han Jo Kim, Eric O. Klineberg, Lawrence G. Lenke, Stephen J. Lewis, Christopher P. Ames, Peter G. Passias, Themistocles S. Protopsaltis, Justin S. Smith, Frank J. Schwab, Virginie Lafage, null International Spine Study Group, and Christopher I. Shaffrey
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
241. P7. Percutaneous delivery of recombinant human bone morphongenetic protein-2 augments fusion in a nicotine impaired rabbit fusion model
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Sohrab S. Virk, Yu-Cheng Yao, Avani Sudhir Vaishnav, Frank J. Schwab, and Sheeraz A. Qureshi
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
242. 160. Survival analysis using fusion status after adult spinal deformity (ASD) surgery with minimum 4-year follow-up
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Thomas Buell, Justin S. Smith, Christopher I. Shaffrey, Shay Bess, Breton Line, Han Jo Kim, Eric O. Klineberg, Virginie Lafage, Renaud Lafage, Themistocles S. Protopsaltis, Peter G. Passias, Gregory M. Mundis, Robert K. Eastlack, Justin K. Scheer, Michael P. Kelly, Alan H. Daniels, Jeffrey L. Gum, Alexandra Soroceanu, Munish C. Gupta, Douglas C. Burton, Richard A. Hostin, Khaled M. Kebaish, Robert A. Hart, Frank J. Schwab, Christopher P. Ames, Nima Alan, Adam S. Kanter, David O. Okonkwo, D. Kojo Hamilton, and null International Spine Study Group
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
243. 165. Hounsfield units thresholds are associated with major intraoperative blood loss and implant complications within 90 days of adult spinal deformity surgery
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Kevin Mo, Micheal Raad, Jeffrey L. Gum, Alexandra Soroceanu, Han Jo Kim, Richard A. Hostin, Peter G. Passias, Renaud Lafage, Themistocles S. Protopsaltis, Munish C. Gupta, Christopher P. Ames, Eric O. Klineberg, D. Kojo Hamilton, Frank J. Schwab, Alan H. Daniels, Robert A. Hart, Breton Line, Christopher I. Shaffrey, Justin S. Smith, Shay Bess, Lawrence G. Lenke, Douglas C. Burton, Khaled M. Kebaish, and null International Spine Study Group
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
244. 147. Proximal junctional failure in primary thoracolumbar fusion/fixation to the sacrum/pelvis for adult symptomatic lumbar scoliosis: long-term follow-up of a prospective multicenter cohort of 160 patients
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Bruno C. Lazaro, Juan P. Sardi, Justin S. Smith, Michael P. Kelly, Brian Dial, Jeffrey M Hills, Christine R. Baldus, Elizabeth Yanik, Chun-Po Yen, Munish C. Gupta, Virginie Lafage, Christopher P. Ames, Shay Bess, Frank J. Schwab, Christopher I. Shaffrey, and Keith H. Bridwell
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
245. 178. All-cause mortality following cervical and thoracolumbar adult deformity surgery: incidence and causes
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Kevin Mo, Justin S. Smith, Peter G. Passias, Peter Tretiakov, Shay Bess, Kevin Wang, Samrat Yeramaneni, Brian J. Neuman, Richard A. Hostin, Jeffrey L. Gum, Renaud Lafage, Themistocles S. Protopsaltis, Munish C. Gupta, Christopher P. Ames, Eric O. Klineberg, D. Kojo Hamilton, Frank J. Schwab, Douglas C. Burton, Alan H. Daniels, Alexandra Soroceanu, Han Jo Kim, Robert A. Hart, Breton Line, Virginie Lafage, Christopher I. Shaffrey, Lawrence G. Lenke, Khaled M. Kebaish, and null International Spine Study Group
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
246. 52. Patients with additional medical comorbidities failed to maintain MCID+ status at five years following adult spinal deformity surgery
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Kevin Mo, Brian J. Neuman, Samrat Yeramaneni, Micheal Raad, Richard A. Hostin, Peter G. Passias, Jeffrey L. Gum, Renaud Lafage, Michael P. Kelly, Themistocles S. Protopsaltis, Munish C. Gupta, Christopher P. Ames, Eric O. Klineberg, D. Kojo Hamilton, Frank J. Schwab, Douglas C. Burton, Alan H. Daniels, Han Jo Kim, Robert A. Hart, Breton Line, Virginie Lafage, Christopher I. Shaffrey, Justin S. Smith, Shay Bess, Lawrence G. Lenke, Khaled M. Kebaish, and null International Spine Study Group
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
247. P125. Evaluating the impact of multiple sclerosis on 2-year postoperative outcomes following long fusion for adult spinal deformity: a propensity score matched analysis
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Ryan Kong, George A. Beyer, Hallie Tiburzi, Neil V Shah, Adam J Wolfert, Bana Hadid, David Kim, Daniel Alsoof, Jad Bou Monsef, Renaud Lafage, Peter G Passias, Frank J. Schwab, Alan H Daniels, Virginie Lafage, Bassel G. Diebo, and Carl B Paulino
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
248. 49. The impact of sagittal alignment on disability decreases after surgery as other factors become more influential: series of 925 patients with two-year follow-up
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Justin K. Scheer, Virginie Lafage, Justin S. Smith, Renaud Lafage, Peter G. Passias, Eric O. Klineberg, Robert A. Hart, Douglas C. Burton, Breton Line, Shay Bess, Christopher I. Shaffrey, Frank J. Schwab, Munish C. Gupta, Christopher P. Ames, and null International Spine Study Group
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Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
249. P103. Complex ASD patients receiving high dose TXA have significantly lower blood loss compared to low dose TXA without increased thromboembolic complications
- Author
-
Kevin Mo, Andrew Harris, Renaud Lafage, Brian J. Neuman, Richard A. Hostin, Samrat Yeramaneni, Alexandra Soroceanu, Han Jo Kim, Eric O. Klineberg, Jeffrey L. Gum, Munish C. Gupta, D. Kojo Hamilton, Frank J. Schwab, Douglas C. Burton, Alan H. Daniels, Peter G. Passias, Themistocles S. Protopsaltis, Michael P. Kelly, Breton Line, Christopher P. Ames, Virginie Lafage, Christopher I. Shaffrey, Justin S. Smith, Shay Bess, Lawrence G. Lenke, Khaled M. Kebaish, and null International Spine Study Group
- Subjects
Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
250. 142. Loss of sagittal correction >3 years after adult spinal deformity surgery
- Author
-
Francis C. Lovecchio, Renaud Lafage, Han Jo Kim, D. Kojo Hamilton, Jeffrey L. Gum, Alexandra Soroceanu, Peter G. Passias, Themistocles S. Protopsaltis, Gregory M. Mundis, Christopher I. Shaffrey, Christopher P. Ames, Eric O. Klineberg, Munish C. Gupta, Douglas C. Burton, Shay Bess, Justin S. Smith, Frank J. Schwab, null International Spine Study Group, and Virginie Lafage
- Subjects
Surgery ,Orthopedics and Sports Medicine ,Neurology (clinical) - Published
- 2022
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