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201. Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia

Author: Comasco, Erika, Vumma, Ravi, Toffoletto, R., Johansson, Jessica, Flyckt, Lena, Lewander, Tommy, Oreland, Lars, Bjerkenstedt, Lars, Andreou, Dimitrios, Söderman, Erik, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G., Venizelos, Nikolaos, Comasco, Erika, Vumma, Ravi, Toffoletto, R., Johansson, Jessica, Flyckt, Lena, Lewander, Tommy, Oreland, Lars, Bjerkenstedt, Lars, Andreou, Dimitrios, Söderman, Erik, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G., and Venizelos, Nikolaos
Abstract: Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Moreover, the involvement of the different isoforms of the system L in tyrosine uptake and LAT1 tyrosine kinetics were studied in fibroblast cell lines of 10 patients with schizophrenia and 10 healthy controls. The results provide suggestive evidence of individual vulnerability to schizophrenia related to the LAT1 SNP rs9936204 genotype. A number of SNPs were nominally associated with CSF HVA and MHPG concentrations but did not survive correction for multiple testing. The LAT1 isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters (maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 isoform) did not differ between patients with schizophrenia and controls. The present genetic findings call for independent replication in larger samples, while the functional study seems to exclude a role of LAT1 in the aberrant transport of tyrosine in fibroblasts of patients with schizophrenia.
Published: 2017
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202. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Author: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Smoller, Jordan, Thompson, Paul M, Stein, Jason L, Medland, Sarah E, Hibar, Derrek P, Vasquez, Alejandro A, Renteria, Miguel E, Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J, Martin, Nicholas G, Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C, Andreassen, Ole A, Apostolova, Liana G, Appel, Katja, Armstrong, Nicola J, Aribisala, Benjamin, Bastin, Mark E, Bauer, Michael, Bearden, Carrie E, Bergmann, Ørjan, Binder, Elisabeth B, Blangero, John, Bockholt, Henry J, Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I, Booth, Tom, Bowman, Ian J, Bralten, Janita, Brouwer, Rachel M, Brunner, Han G, Brohawn, David G, Buckner, Randy L, Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R, Calhoun, Vince D, Cannon, Dara M, Cantor, Rita M, Carless, Melanie A, Caseras, Xavier, Cavalleri, Gianpiero L, Chakravarty, M. M, Chang, Kiki D, Ching, Christopher R K, Christoforou, Andrea, Cichon, Sven, Clark, Vincent P, Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Deary, Ian J, de Geus, Eco J C, den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I, Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D, Ehrlich, Stefan, Ekman, Carl J, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E, Foroud, Tatiana, Fox, Peter T, Francks, Clyde, Frangou, Sophia, Frey, Eva M, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C, Godlewska, Beata, Goldstein, Rita Z, Gollub, Randy L, Grabe, Hans J, Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E, Gur, Ruben C, Göring, Harald H H, Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B, Hall, Jeremy, Hardy, John, Hartman, Catharina A, Hass, Johanna, Hatton, Sean N, Haukvik, Unn K, Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B, Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J, Hollinshead, Marisa, Holmes, Avram J, Homuth, Georg, Hoogman, Martine, Hong, L. E, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E, Hwang, Kristy S, Jack, Clifford R, Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G, Kahn, René S, Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B J, Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A, Lauriello, John, Lawrie, Stephen M, Lee, Phil H, Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D, Li, Chiang-shan, Liberg, Benny, Liewald, David C, Liu, Xinmin, Lopez, Lorna M, Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W J, MacQueen, Glenda M, Malt, Ulrik F, Mandl, René, Manoach, Dara S, Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M, McMahon, Francis J, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Moses, Eric K, Mueller, Bryon A, Muñoz Maniega, Susana, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E, Nilsson, Lars-Göran, Nugent, Allison C, Nyberg, Lars, Olvera, Rene L, Oosterlaan, Jaap, Ophoff, Roel A, Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D, Penninx, Brenda W, Peterson, Charles P, Pfennig, Andrea, Phillips, Mary, Pike, G. B, Poline, Jean-Baptiste, Potkin, Steven G, Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L, Roffman, Joshua L, Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J, Royle, Natalie A, Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S, Salami, Alireza, Satterthwaite, Theodore D, Savitz, Jonathan, Saykin, Andrew J, Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G, Schork, Andrew J, Schulz, S. C, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M, Simmons, Andrew, Sisodiya, Sanjay M, Smith, Colin, Soares, Jair C, Sponheim, Scott R, Sprooten, Emma, Starr, John M, Steen, Vidar M, Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G, Teumer, Alexander, Toga, Arthur W, Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J, van Eijk, Kristel, van Erp, Theo G M, van Haren, Neeltje E M, van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C, Veltman, Dick J, Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M, Weale, Michael E, Weiner, Michael W, Wen, Wei, Westlye, Lars T, Whalley, Heather C, Whelan, Christopher D, White, Tonya, Winkler, Anderson M, Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P, Thalamuthu, Anbupalam, Schofield, Peter R, Freimer, Nelson B, Lawrence, Natalia S, Drevets, Wayne, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Smoller, Jordan, Thompson, Paul M, Stein, Jason L, Medland, Sarah E, Hibar, Derrek P, Vasquez, Alejandro A, Renteria, Miguel E, Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J, Martin, Nicholas G, Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C, Andreassen, Ole A, Apostolova, Liana G, Appel, Katja, Armstrong, Nicola J, Aribisala, Benjamin, Bastin, Mark E, Bauer, Michael, Bearden, Carrie E, Bergmann, Ørjan, Binder, Elisabeth B, Blangero, John, Bockholt, Henry J, Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I, Booth, Tom, Bowman, Ian J, Bralten, Janita, Brouwer, Rachel M, Brunner, Han G, Brohawn, David G, Buckner, Randy L, Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R, Calhoun, Vince D, Cannon, Dara M, Cantor, Rita M, Carless, Melanie A, Caseras, Xavier, Cavalleri, Gianpiero L, Chakravarty, M. M, Chang, Kiki D, Ching, Christopher R K, Christoforou, Andrea, Cichon, Sven, Clark, Vincent P, Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Deary, Ian J, de Geus, Eco J C, den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I, Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D, Ehrlich, Stefan, Ekman, Carl J, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E, Foroud, Tatiana, Fox, Peter T, Francks, Clyde, Frangou, Sophia, Frey, Eva M, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C, Godlewska, Beata, Goldstein, Rita Z, Gollub, Randy L, Grabe, Hans J, Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E, Gur, Ruben C, Göring, Harald H H, Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B, Hall, Jeremy, Hardy, John, Hartman, Catharina A, Hass, Johanna, Hatton, Sean N, Haukvik, Unn K, Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B, Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J, Hollinshead, Marisa, Holmes, Avram J, Homuth, Georg, Hoogman, Martine, Hong, L. E, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E, Hwang, Kristy S, Jack, Clifford R, Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G, Kahn, René S, Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B J, Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A, Lauriello, John, Lawrie, Stephen M, Lee, Phil H, Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D, Li, Chiang-shan, Liberg, Benny, Liewald, David C, Liu, Xinmin, Lopez, Lorna M, Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W J, MacQueen, Glenda M, Malt, Ulrik F, Mandl, René, Manoach, Dara S, Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M, McMahon, Francis J, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Moses, Eric K, Mueller, Bryon A, Muñoz Maniega, Susana, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E, Nilsson, Lars-Göran, Nugent, Allison C, Nyberg, Lars, Olvera, Rene L, Oosterlaan, Jaap, Ophoff, Roel A, Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D, Penninx, Brenda W, Peterson, Charles P, Pfennig, Andrea, Phillips, Mary, Pike, G. B, Poline, Jean-Baptiste, Potkin, Steven G, Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L, Roffman, Joshua L, Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J, Royle, Natalie A, Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S, Salami, Alireza, Satterthwaite, Theodore D, Savitz, Jonathan, Saykin, Andrew J, Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G, Schork, Andrew J, Schulz, S. C, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M, Simmons, Andrew, Sisodiya, Sanjay M, Smith, Colin, Soares, Jair C, Sponheim, Scott R, Sprooten, Emma, Starr, John M, Steen, Vidar M, Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G, Teumer, Alexander, Toga, Arthur W, Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J, van Eijk, Kristel, van Erp, Theo G M, van Haren, Neeltje E M, van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C, Veltman, Dick J, Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M, Weale, Michael E, Weiner, Michael W, Wen, Wei, Westlye, Lars T, Whalley, Heather C, Whelan, Christopher D, White, Tonya, Winkler, Anderson M, Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P, Thalamuthu, Anbupalam, Schofield, Peter R, Freimer, Nelson B, Lawrence, Natalia S, and Drevets, Wayne
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
Published: 2017

203. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Author: Marshall, Christian R., Howrigan, Daniel P., Merico, Daniele, Thiruvahindrapuram, Bhooma, Wu, Wenting, Greer, Douglas S., Antaki, Danny, Shetty, Aniket, Holmans, Peter A., Pinto, Dalila, Gujral, Madhusudan, Brandler, William M., Malhotra, Dheeraj, Wang, Zhouzhi, Fuentes Fajarado, Karin V., Maile, Michelle S., Ripke, Stephan, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amin, Farooq, Atkins, Joshua, Bacanu, Silviu A., Belliveau, Richard A., Bergen, Sarah E., Bertalan, Marcelo, Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Bulik-Sullivan, Brendan, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Cheng, Wei, Cloninger, C. Robert, Cohen, David, Cormican, Paul, Craddock, Nick, Crespo-Facorro, Benedicto, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E., Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farh, Kai How, Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedman, Joseph I., Forstner, Andreas J., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Gratten, Jacob, De Haan, Lieuwe, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Huang, Hailiang, Ikeda, Masashi, Joa, Inge, Kähler, Anna K., Kahn, René S., Kalaydjieva, Luba, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kelly, Brian J., Kennedy, James L., Kim, Yunjung, Knowles, James A., Konte, Bettina, Laurent, Claudine, Lee, Phil, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Levy, Deborah L., Liang, Kung Yee, Lieberman, Jeffrey, Lönnqvist, Jouko, Loughland, Carmel M., Magnusson, Patrik K E, Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Müller-Myhsok, Bertram, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, Oh, Sang Yun, Olincy, Ann, Olsen, Line, O'Neill, F. Anthony, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Perkins, Diana O., Pers, Tune Hannes, Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, H. B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Savitz, Adam, Schall, Ulrich, Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Silverman, Jeremy M., Smoller, Jordan W., Söderman, Erik, Spencer, Chris C A, Stahl, Eli A., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Thirumalai, Srinivas, Tooney, Paul A., Veijola, Juha, Visscher, Peter M., Waddington, John, Walsh, Dermot, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wormley, Brandon K., Wray, Naomi R., Wu, J. Q., Zai, Clement C., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D., Cichon, Sven, Collier, David A., Corvin, Aiden, Daly, Mark J., Darvasi, Ariel, Domenici, Enrico, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Levinson, Douglas F., Li, Qingqin S., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sklar, Pamela, St Clair, David, Walters, James T R, Werge, Thomas, Sullivan, Patrick F., O'Donovan, Michael C., Scherer, Stephen W., Neale, Benjamin M., Sebat, Jonathan, Marshall, Christian R., Howrigan, Daniel P., Merico, Daniele, Thiruvahindrapuram, Bhooma, Wu, Wenting, Greer, Douglas S., Antaki, Danny, Shetty, Aniket, Holmans, Peter A., Pinto, Dalila, Gujral, Madhusudan, Brandler, William M., Malhotra, Dheeraj, Wang, Zhouzhi, Fuentes Fajarado, Karin V., Maile, Michelle S., Ripke, Stephan, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amin, Farooq, Atkins, Joshua, Bacanu, Silviu A., Belliveau, Richard A., Bergen, Sarah E., Bertalan, Marcelo, Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Bulik-Sullivan, Brendan, Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Cheng, Wei, Cloninger, C. Robert, Cohen, David, Cormican, Paul, Craddock, Nick, Crespo-Facorro, Benedicto, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E., Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farh, Kai How, Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedman, Joseph I., Forstner, Andreas J., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Gratten, Jacob, De Haan, Lieuwe, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Huang, Hailiang, Ikeda, Masashi, Joa, Inge, Kähler, Anna K., Kahn, René S., Kalaydjieva, Luba, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kelly, Brian J., Kennedy, James L., Kim, Yunjung, Knowles, James A., Konte, Bettina, Laurent, Claudine, Lee, Phil, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Levy, Deborah L., Liang, Kung Yee, Lieberman, Jeffrey, Lönnqvist, Jouko, Loughland, Carmel M., Magnusson, Patrik K E, Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Müller-Myhsok, Bertram, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, Oh, Sang Yun, Olincy, Ann, Olsen, Line, O'Neill, F. Anthony, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Perkins, Diana O., Pers, Tune Hannes, Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, H. B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Savitz, Adam, Schall, Ulrich, Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Silverman, Jeremy M., Smoller, Jordan W., Söderman, Erik, Spencer, Chris C A, Stahl, Eli A., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Thirumalai, Srinivas, Tooney, Paul A., Veijola, Juha, Visscher, Peter M., Waddington, John, Walsh, Dermot, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wormley, Brandon K., Wray, Naomi R., Wu, J. Q., Zai, Clement C., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D., Cichon, Sven, Collier, David A., Corvin, Aiden, Daly, Mark J., Darvasi, Ariel, Domenici, Enrico, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Levinson, Douglas F., Li, Qingqin S., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sklar, Pamela, St Clair, David, Walters, James T R, Werge, Thomas, Sullivan, Patrick F., O'Donovan, Michael C., Scherer, Stephen W., Neale, Benjamin M., and Sebat, Jonathan
Abstract: Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10-6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10-11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10-5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
Published: 2017

204. No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

Author: Johnson, Emma C., Bjelland, Douglas W., Howrigan, Daniel P., Abdellaoui, Abdel, Breen, Gerome, Borglum, Anders, Cichon, Sven, Degenhardt, Franziska, Forstner, Andreas J., Frank, Josef, Genovese, Giulio, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffman, Per, Maier, Wolfgang, Mattheisen, Manuel, Morris, Derek, Mowry, Bryan, Müller-Mhysok, Betram, Neale, Benjamin, Nenadic, Igor, Nöthen, Markus M., O’Dushlaine, Colm, Rietschel, Marcella, Ruderfer, Douglas M., Rujescu, Dan, Schulze, Thomas G., Simonson, Matthew A., Stahl, Eli, Strohmaier, Jana, Witt, Stephanie H., Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T R, Farh, Kai How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C K, Chen, Ronald Y L, Chen, Eric Y H, Cheng, Wei, Cheung, Eric F C, Chong, Siow Ann, Robert Cloninger, C., Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Chee Keong, Jimmy Lee, Hong Lee, S., Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K E, Maher, Brion S., Mallet, Jacques, Marsal, Sara, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, Anthony O'Neill, F., Oh, Sang Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon Cheong, Spencer, Chris C A, Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Scott Stroup, T., Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Wolen, Aaron R., Wong, Emily H M, Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Riley, Brien P., Sham, Pak C., Sklar, Pamela, Clair, David S., Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., O'Donovan, Michael C., Sullivan, Patrick F., Keller, Matthew C., Biological Psychology, Johnson, Emma C, Bjelland, Douglas W, Howrigan, Daniel P, Abdellaoui, Abdel, Lee, S Hong, Keller, Matthew C, and Schizophrenia Working Group of the Psychiatric Genomics Consortium
Subjects: 0301 basic medicine, Male, Cancer Research, Heredity, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Genetics, Genetics (clinical), Social Sciences, Genome-wide association study, Disease, 030105 genetics & heredity, Runs of Homozygosity, Homozygosity, Consanguinity, Sociology, Polymorphism (computer science), Consortia, Medicine and Health Sciences, Genetics(clinical), Inbreeding, Ecology, Depression, Homozygote, Genomics, 3. Good health, Schizophrenia, Research Design, Physical Sciences, Female, Statistics (Mathematics), Research Article, lcsh:QH426-470, Evolution, Replication Studies, inbreeding, Single-nucleotide polymorphism, Biology, Genome Complexity, Research and Analysis Methods, Polymorphism, Single Nucleotide, 03 medical and health sciences, SDG 17 - Partnerships for the Goals, Behavior and Systematics, SDG 3 - Good Health and Well-being, Mental Health and Psychiatry, medicine, Confidence Intervals, Humans, replication study, Mood Disorders, Genome, Human, Biology and Life Sciences, Computational Biology, medicine.disease, schizophrenia, lcsh:Genetics, 030104 developmental biology, homozygosity, Mathematics, Genome-Wide Association Study
Abstract: It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest., Author Summary It is well known that mating between relatives increases the risk that a child will have a rare recessive genetic disease, but there has also been increasing interest and inconsistent findings on whether inbreeding is a risk factor for common, complex psychiatric disorders such as schizophrenia. The best powered study to date investigating this theory predicted that the odds of developing schizophrenia increase by approximately 17% for every additional percent of the genome that shows evidence of inbreeding. In this replication, we used genome-wide single nucleotide polymorphism data from 18,562 schizophrenia cases and 21,268 controls to quantify the degree to which they were inbred and to test the hypothesis that schizophrenia cases show higher mean levels of inbreeding. Contrary to the original study, we did not find evidence for distant inbreeding to play a role in schizophrenia risk. There are various confounding factors that could explain the discrepancy in results from the original study and our replication, and this should serve as a cautionary note–careful attention should be paid to issues like ascertainment when using the data from genome-wide case-control association studies for secondary analyses for which the data may not have originally been intended.
Published: 2016

205. Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Author: Satizabal, Claudia L, primary, Adams, Hieab HH, additional, Hibar, Derrek P, additional, White, Charles C, additional, Stein, Jason L, additional, Scholz, Markus, additional, Sargurupremraj, Murali, additional, Jahanshad, Neda, additional, Smith, Albert V, additional, Bis, Joshua C, additional, Jian, Xueqiu, additional, Luciano, Michelle, additional, Hofer, Edith, additional, Teumer, Alexander, additional, van der Lee, Sven J, additional, Yang, Jingyun, additional, Yanek, Lisa R, additional, Lee, Tom V, additional, Li, Shuo, additional, Hu, Yanhui, additional, Koh, Jia Yu, additional, Eicher, John D, additional, Desrivières, Sylvane, additional, Arias-Vasquez, Alejandro, additional, Chauhan, Ganesh, additional, Athanasiu, Lavinia, additional, Renteria, Miguel E, additional, Kim, Sungeun, additional, Höhn, David, additional, Armstrong, Nicola J, additional, Chen, Qiang, additional, Holmes, Avram J, additional, Braber, Anouk den, additional, Kloszewska, Iwona, additional, Andersson, Micael, additional, Espeseth, Thomas, additional, Grimm, Oliver, additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Milaneschi, Yuri, additional, Papmeyer, Martina, additional, Axelsson, Tomas, additional, Ehrlich, Stefan, additional, Roiz-Santiañez, Roberto, additional, Kraemer, Bernd, additional, Håberg, Asta K, additional, Jones, Hannah J, additional, Pike, G Bruce, additional, Stein, Dan J, additional, Stevens, Allison, additional, Bralten, Janita, additional, Vernooij, Meike W, additional, Harris, Tamara B, additional, Filippi, Irina, additional, Witte, A Veronica, additional, Guadalupe, Tulio, additional, Wittfeld, Katharina, additional, Mosley, Thomas H, additional, Becker, James T, additional, Doan, Nhat Trung, additional, Hagenaars, Saskia P, additional, Saba, Yasaman, additional, Cuellar-Partida, Gabriel, additional, Amin, Najaf, additional, Hilal, Saima, additional, Nho, Kwangsik, additional, Karbalai, Nazanin, additional, Arfanakis, Konstantinos, additional, Becker, Diane M, additional, Ames, David, additional, Goldman, Aaron L, additional, Lee, Phil H, additional, Boomsma, Dorret I, additional, Lovestone, Simon, additional, Giddaluru, Sudheer, additional, Le Hellard, Stephanie, additional, Mattheisen, Manuel, additional, Bohlken, Marc M, additional, Kasperaviciute, Dalia, additional, Schmaal, Lianne, additional, Lawrie, Stephen M, additional, Agartz, Ingrid, additional, Walton, Esther, additional, Tordesillas-Gutierrez, Diana, additional, Davies, Gareth E, additional, Shin, Jean, additional, Ipser, Jonathan C, additional, Vinke, Louis N, additional, Hoogman, Martine, additional, Knol, Maria J, additional, Jia, Tianye, additional, Burkhardt, Ralph, additional, Klein, Marieke, additional, Crivello, Fabrice, additional, Janowitz, Deborah, additional, Carmichael, Owen, additional, Haukvik, Unn K, additional, Aribisala, Benjamin S, additional, Schmidt, Helena, additional, Strike, Lachlan T, additional, Cheng, Ching-Yu, additional, Risacher, Shannon L, additional, Pütz, Benno, additional, Fleischman, Debra A, additional, Assareh, Amelia A, additional, Mattay, Venkata S, additional, Buckner, Randy L, additional, Mecocci, Patrizia, additional, Dale, Anders M, additional, Cichon, Sven, additional, Boks, Marco P, additional, Matarin, Mar, additional, Penninx, Brenda WJH, additional, Calhoun, Vince D, additional, Chakravarty, M Mallar, additional, Marquand, Andre, additional, Macare, Christine, additional, Masouleh, Shahrzad Kharabian, additional, Oosterlaan, Jaap, additional, Amouyel, Philippe, additional, Hegenscheid, Katrin, additional, Rotter, Jerome I, additional, Schork, Andrew J, additional, Liewald, David CM, additional, De Zubicaray, Greig I, additional, Wong, Tien Yin, additional, Shen, Li, additional, Sämann, Philipp G, additional, Brodaty, Henry, additional, Roffman, Joshua L, additional, De Geus, Eco JC, additional, Tsolaki, Magda, additional, Erk, Susanne, additional, Van Eijk, Kristel R, additional, Cavalleri, Gianpiero L, additional, Van der Wee, Nic JA, additional, McIntosh, Andrew M, additional, Gollub, Randy L, additional, Bulayeva, Kazima B, additional, Bernard, Manon, additional, Richards, Jennifer S, additional, Himali, Jayandra J, additional, Loeffler, Markus, additional, Rommelse, Nanda, additional, Hoffmann, Wolfgang, additional, Westlye, Lars T, additional, Valdés Hernández, Maria C, additional, Hansell, Narelle K, additional, Van Erp, Theo GM, additional, Wolf, Christiane, additional, Kwok, John BJ, additional, Vellas, Bruno, additional, Heinz, Andreas, additional, Loohuis, Loes M Olde, additional, Delanty, Norman, additional, Ho, Beng-Choon, additional, Ching, Christopher RK, additional, Shumskaya, Elena, additional, Hofman, Albert, additional, Van der Meer, Dennis, additional, Homuth, Georg, additional, Psaty, Bruce M, additional, Bastin, Mark, additional, Montgomery, Grant W, additional, Foroud, Tatiana M, additional, Reppermund, Simone, additional, Hottenga, Jouke-Jan, additional, Simmons, Andrew, additional, Meyer-Lindenberg, Andreas, additional, Cahn, Wiepke, additional, Whelan, Christopher D, additional, Van Donkelaar, Marjolein MJ, additional, Yang, Qiong, additional, Hosten, Norbert, additional, Green, Robert C, additional, Thalamuthu, Anbupalam, additional, Mohnke, Sebastian, additional, Pol, Hilleke E Hulshoff, additional, Lin, Honghuang, additional, Jack, Clifford R, additional, Schofield, Peter R, additional, Mühleisen, Thomas W, additional, Maillard, Pauline, additional, Potkin, Steven G, additional, Wen, Wei, additional, Fletcher, Evan, additional, Toga, Arthur W, additional, Gruber, Oliver, additional, Huentelman, Matthew, additional, Smith, George Davey, additional, Launer, Lenore J, additional, Nyberg, Lars, additional, Jönsson, Erik G, additional, Crespo-Facorro, Benedicto, additional, Koen, Nastassja, additional, Greve, Douglas, additional, Uitterlinden, André G, additional, Weinberger, Daniel R, additional, Steen, Vidar M, additional, Fedko, Iryna O, additional, Groenewold, Nynke A, additional, Niessen, Wiro J, additional, Toro, Roberto, additional, Tzourio, Christophe, additional, Longstreth, William T, additional, Ikram, M Kamran, additional, Smoller, Jordan W, additional, Van Tol, Marie-Jose, additional, Sussmann, Jessika E, additional, Paus, Tomas, additional, Lemaître, Hervé, additional, Mazoyer, Bernard, additional, Andreassen, Ole A, additional, Holsboer, Florian, additional, Veltman, Dick J, additional, Turner, Jessica A, additional, Pausova, Zdenka, additional, Schumann, Gunter, additional, Van Rooij, Daan, additional, Djurovic, Srdjan, additional, Deary, Ian J, additional, McMahon, Katie L, additional, Müller-Myhsok, Bertram, additional, Brouwer, Rachel M, additional, Soininen, Hilkka, additional, Pandolfo, Massimo, additional, Wassink, Thomas H, additional, Cheung, Joshua W, additional, Wolfers, Thomas, additional, Martinot, Jean-Luc, additional, Zwiers, Marcel P, additional, Nauck, Matthias, additional, Melle, Ingrid, additional, Martin, Nicholas G, additional, Kanai, Ryota, additional, Westman, Eric, additional, Kahn, René S, additional, Sisodiya, Sanjay M, additional, White, Tonya, additional, Saremi, Arvin, additional, van Bokhoven, Hans, additional, Brunner, Han G, additional, Völzke, Henry, additional, Wright, Margaret J, additional, Van 't Ent, Dennis, additional, Nöthen, Markus M, additional, Ophoff, Roel A, additional, Buitelaar, Jan K, additional, Fernández, Guillén, additional, Sachdev, Perminder S, additional, Rietschel, Marcella, additional, Van Haren, Neeltje EM, additional, Fisher, Simon E, additional, Beiser, Alexa S, additional, Francks, Clyde, additional, Saykin, Andrew J, additional, Mather, Karen A, additional, Romanczuk-Seiferth, Nina, additional, Hartman, Catharina A, additional, DeStefano, Anita L, additional, Heslenfeld, Dirk J, additional, Weiner, Michael W, additional, Walter, Henrik, additional, Hoekstra, Pieter J, additional, Nyquist, Paul A, additional, Franke, Barbara, additional, Bennett, David A, additional, Grabe, Hans J, additional, Johnson, Andrew D, additional, Chen, Christopher, additional, van Duijn, Cornelia M, additional, Lopez, Oscar L, additional, Fornage, Myriam, additional, Wardlaw, Joanna A, additional, Schmidt, Reinhold, additional, DeCarli, Charles, additional, De Jager, Philip L, additional, Villringer, Arno, additional, Debette, Stéphanie, additional, Gudnason, Vilmundur, additional, Medland, Sarah E, additional, Shulman, Joshua M, additional, Thompson, Paul M, additional, Seshadri, Sudha, additional, and Ikram, M Arfan, additional
Published: 2017
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206. The quality of severe mental disorder diagnoses in a national health registry as compared to research diagnoses based on structured interview

Author: Nesvåg, Ragnar, primary, Jönsson, Erik G., additional, Bakken, Inger Johanne, additional, Knudsen, Gun Peggy, additional, Bjella, Thomas D., additional, Reichborn-Kjennerud, Ted, additional, Melle, Ingrid, additional, and Andreassen, Ole A., additional
Published: 2017
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207. Novel genetic loci associated with hippocampal volume

Author: Hibar, Derrek P., primary, Adams, Hieab H. H., additional, Jahanshad, Neda, additional, Chauhan, Ganesh, additional, Stein, Jason L., additional, Hofer, Edith, additional, Renteria, Miguel E., additional, Bis, Joshua C., additional, Arias-Vasquez, Alejandro, additional, Ikram, M. Kamran, additional, Desrivières, Sylvane, additional, Vernooij, Meike W., additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Amin, Najaf, additional, Andersson, Micael, additional, Arfanakis, Konstantinos, additional, Aribisala, Benjamin S., additional, Armstrong, Nicola J., additional, Athanasiu, Lavinia, additional, Axelsson, Tomas, additional, Beecham, Ashley H., additional, Beiser, Alexa, additional, Bernard, Manon, additional, Blanton, Susan H., additional, Bohlken, Marc M., additional, Boks, Marco P., additional, Bralten, Janita, additional, Brickman, Adam M., additional, Carmichael, Owen, additional, Chakravarty, M. Mallar, additional, Chen, Qiang, additional, Ching, Christopher R. K., additional, Chouraki, Vincent, additional, Cuellar-Partida, Gabriel, additional, Crivello, Fabrice, additional, Den Braber, Anouk, additional, Doan, Nhat Trung, additional, Ehrlich, Stefan, additional, Giddaluru, Sudheer, additional, Goldman, Aaron L., additional, Gottesman, Rebecca F., additional, Grimm, Oliver, additional, Griswold, Michael E., additional, Guadalupe, Tulio, additional, Gutman, Boris A., additional, Hass, Johanna, additional, Haukvik, Unn K., additional, Hoehn, David, additional, Holmes, Avram J., additional, Hoogman, Martine, additional, Janowitz, Deborah, additional, Jia, Tianye, additional, Jørgensen, Kjetil N., additional, Karbalai, Nazanin, additional, Kasperaviciute, Dalia, additional, Kim, Sungeun, additional, Klein, Marieke, additional, Kraemer, Bernd, additional, Lee, Phil H., additional, Liewald, David C. M., additional, Lopez, Lorna M., additional, Luciano, Michelle, additional, Macare, Christine, additional, Marquand, Andre F., additional, Matarin, Mar, additional, Mather, Karen A., additional, Mattheisen, Manuel, additional, McKay, David R., additional, Milaneschi, Yuri, additional, Muñoz Maniega, Susana, additional, Nho, Kwangsik, additional, Nugent, Allison C., additional, Nyquist, Paul, additional, Loohuis, Loes M. Olde, additional, Oosterlaan, Jaap, additional, Papmeyer, Martina, additional, Pirpamer, Lukas, additional, Pütz, Benno, additional, Ramasamy, Adaikalavan, additional, Richards, Jennifer S., additional, Risacher, Shannon L., additional, Roiz-Santiañez, Roberto, additional, Rommelse, Nanda, additional, Ropele, Stefan, additional, Rose, Emma J., additional, Royle, Natalie A., additional, Rundek, Tatjana, additional, Sämann, Philipp G., additional, Saremi, Arvin, additional, Satizabal, Claudia L., additional, Schmaal, Lianne, additional, Schork, Andrew J., additional, Shen, Li, additional, Shin, Jean, additional, Shumskaya, Elena, additional, Smith, Albert V., additional, Sprooten, Emma, additional, Strike, Lachlan T., additional, Teumer, Alexander, additional, Tordesillas-Gutierrez, Diana, additional, Toro, Roberto, additional, Trabzuni, Daniah, additional, Trompet, Stella, additional, Vaidya, Dhananjay, additional, Van der Grond, Jeroen, additional, Van der Lee, Sven J., additional, Van der Meer, Dennis, additional, Van Donkelaar, Marjolein M. J., additional, Van Eijk, Kristel R., additional, Van Erp, Theo G. M., additional, Van Rooij, Daan, additional, Walton, Esther, additional, Westlye, Lars T., additional, Whelan, Christopher D., additional, Windham, Beverly G., additional, Winkler, Anderson M., additional, Wittfeld, Katharina, additional, Woldehawariat, Girma, additional, Wolf, Christiane, additional, Wolfers, Thomas, additional, Yanek, Lisa R., additional, Yang, Jingyun, additional, Zijdenbos, Alex, additional, Zwiers, Marcel P., additional, Agartz, Ingrid, additional, Almasy, Laura, additional, Ames, David, additional, Amouyel, Philippe, additional, Andreassen, Ole A., additional, Arepalli, Sampath, additional, Assareh, Amelia A., additional, Barral, Sandra, additional, Bastin, Mark E., additional, Becker, Diane M., additional, Becker, James T., additional, Bennett, David A., additional, Blangero, John, additional, van Bokhoven, Hans, additional, Boomsma, Dorret I., additional, Brodaty, Henry, additional, Brouwer, Rachel M., additional, Brunner, Han G., additional, Buckner, Randy L., additional, Buitelaar, Jan K., additional, Bulayeva, Kazima B., additional, Cahn, Wiepke, additional, Calhoun, Vince D., additional, Cannon, Dara M., additional, Cavalleri, Gianpiero L., additional, Cheng, Ching-Yu, additional, Cichon, Sven, additional, Cookson, Mark R., additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Curran, Joanne E., additional, Czisch, Michael, additional, Dale, Anders M., additional, Davies, Gareth E., additional, De Craen, Anton J. M., additional, De Geus, Eco J. C., additional, De Jager, Philip L., additional, De Zubicaray, Greig I., additional, Deary, Ian J., additional, Debette, Stéphanie, additional, DeCarli, Charles, additional, Delanty, Norman, additional, Depondt, Chantal, additional, DeStefano, Anita, additional, Dillman, Allissa, additional, Djurovic, Srdjan, additional, Donohoe, Gary, additional, Drevets, Wayne C., additional, Duggirala, Ravi, additional, Dyer, Thomas D., additional, Enzinger, Christian, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Fedko, Iryna O., additional, Fernández, Guillén, additional, Ferrucci, Luigi, additional, Fisher, Simon E., additional, Fleischman, Debra A., additional, Ford, Ian, additional, Fornage, Myriam, additional, Foroud, Tatiana M., additional, Fox, Peter T., additional, Francks, Clyde, additional, Fukunaga, Masaki, additional, Gibbs, J. Raphael, additional, Glahn, David C., additional, Gollub, Randy L., additional, Göring, Harald H. H., additional, Green, Robert C., additional, Gruber, Oliver, additional, Gudnason, Vilmundur, additional, Guelfi, Sebastian, additional, Håberg, Asta K., additional, Hansell, Narelle K., additional, Hardy, John, additional, Hartman, Catharina A., additional, Hashimoto, Ryota, additional, Hegenscheid, Katrin, additional, Heinz, Andreas, additional, Le Hellard, Stephanie, additional, Hernandez, Dena G., additional, Heslenfeld, Dirk J., additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J., additional, Hoffmann, Wolfgang, additional, Hofman, Albert, additional, Holsboer, Florian, additional, Homuth, Georg, additional, Hosten, Norbert, additional, Hottenga, Jouke-Jan, additional, Huentelman, Matthew, additional, Hulshoff Pol, Hilleke E., additional, Ikeda, Masashi, additional, Jack Jr, Clifford R., additional, Jenkinson, Mark, additional, Johnson, Robert, additional, Jönsson, Erik G., additional, Jukema, J. Wouter, additional, Kahn, René S., additional, Kanai, Ryota, additional, Kloszewska, Iwona, additional, Knopman, David S., additional, Kochunov, Peter, additional, Kwok, John B., additional, Lawrie, Stephen M., additional, Lemaître, Hervé, additional, Liu, Xinmin, additional, Longo, Dan L., additional, Lopez, Oscar L., additional, Lovestone, Simon, additional, Martinez, Oliver, additional, Martinot, Jean-Luc, additional, Mattay, Venkata S., additional, McDonald, Colm, additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, McMahon, Katie L., additional, Mecocci, Patrizia, additional, Melle, Ingrid, additional, Meyer-Lindenberg, Andreas, additional, Mohnke, Sebastian, additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mosley, Thomas H., additional, Mühleisen, Thomas W., additional, Müller-Myhsok, Bertram, additional, Nalls, Michael A., additional, Nauck, Matthias, additional, Nichols, Thomas E., additional, Niessen, Wiro J., additional, Nöthen, Markus M., additional, Nyberg, Lars, additional, Ohi, Kazutaka, additional, Olvera, Rene L., additional, Ophoff, Roel A., additional, Pandolfo, Massimo, additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Penninx, Brenda W. J. H., additional, Pike, G. Bruce, additional, Potkin, Steven G., additional, Psaty, Bruce M., additional, Reppermund, Simone, additional, Rietschel, Marcella, additional, Roffman, Joshua L., additional, Romanczuk-Seiferth, Nina, additional, Rotter, Jerome I., additional, Ryten, Mina, additional, Sacco, Ralph L., additional, Sachdev, Perminder S., additional, Saykin, Andrew J., additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Schofield, Peter R., additional, Sigursson, Sigurdur, additional, Simmons, Andrew, additional, Singleton, Andrew, additional, Sisodiya, Sanjay M., additional, Smith, Colin, additional, Smoller, Jordan W., additional, Soininen, Hilkka, additional, Steen, Vidar M., additional, Stott, David J., additional, Sussmann, Jessika E., additional, Thalamuthu, Anbupalam, additional, Toga, Arthur W., additional, Traynor, Bryan J., additional, Troncoso, Juan, additional, Tsolaki, Magda, additional, Tzourio, Christophe, additional, Uitterlinden, Andre G., additional, Hernández, Maria C. Valdés, additional, Van der Brug, Marcel, additional, van der Lugt, Aad, additional, van der Wee, Nic J. A., additional, Van Haren, Neeltje E. M., additional, van ’t Ent, Dennis, additional, Van Tol, Marie-Jose, additional, Vardarajan, Badri N., additional, Vellas, Bruno, additional, Veltman, Dick J., additional, Völzke, Henry, additional, Walter, Henrik, additional, Wardlaw, Joanna M., additional, Wassink, Thomas H., additional, Weale, Michael E., additional, Weinberger, Daniel R., additional, Weiner, Michael W., additional, Wen, Wei, additional, Westman, Eric, additional, White, Tonya, additional, Wong, Tien Y., additional, Wright, Clinton B., additional, Zielke, Ronald H., additional, Zonderman, Alan B., additional, Martin, Nicholas G., additional, Van Duijn, Cornelia M., additional, Wright, Margaret J., additional, Longstreth, W. T., additional, Schumann, Gunter, additional, Grabe, Hans J., additional, Franke, Barbara, additional, Launer, Lenore J., additional, Medland, Sarah E., additional, Seshadri, Sudha, additional, Thompson, Paul M., additional, and Ikram, M. Arfan, additional
Published: 2017
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208. Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Author: Sønderby, Ida E., Gústafsson, Ómar, Doan, Nhat Trung, Hibar, Derrek P., Martin-Brevet, Sandra, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Michael, Armstrong, Nicola J., Bernard, Manon, Blackburn, Nicholas, Blangero, John, Boomsma, Dorret I., Bralten, Janita, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M., Bülow, Robin, Calhoun, Vince, Caspers, Svenja, Cavalleri, Gianpiero, Chen, Chi-Hua, Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E., Dale, Anders M., Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco J. C., de Zubicaray, Greig I., de Zwarte, Sonja M. C., Delanty, Norman, den Braber, Anouk, Desrivières, Sylvane, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Espeseth, Thomas, Fisher, Simon E., Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C., Grabe, Hans, Groenewold, Nynke A., Haavik, Jan, Håberg, Asta, Hashimoto, Ryota, Hehir-Kwa, Jayne Y., Heinz, Andreas, Hillegers, Manon H. J., Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E., Ikeda, Masashi, Jahanshad, Neda, Jernigan, Terry, Jockwitz, Christiane, Johansson, Stefan, Jonsdottir, Gudrun A., Jönsson, Erik G., Kahn, Rene, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Knowles, Emma E. M., Kolskår, Knut K., Kwok, John B., Hellard, Stephanie Le, Leu, Costin, Liu, Jingyu, Lundervold, Astri J., Lundervold, Arvid, Martin, Nicholas G., Mather, Karen, Mathias, Samuel R., McCormack, Mark, McMahon, Katie L., McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Mühleisen, Thomas W., Murray, Robin, Nordvik, Jan E., Nyberg, Lars, Olde Loohuis, Loes M., Ophoff, Roel, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda, Peralta, Juan M., Pike, Bruce, Prieto, Carlos, Pudas, Sara, Quinlan, Erin, Quintana, Daniel S., Reinbold, Céline S., Marques, Tiago Reis, Reymond, Alexandre, Richard, Genevieve, Rodriguez-Herreros, Borja, Roiz-Santiañez, Roberto, Rokicki, Jarek, Rucker, James, Sachdev, Perminder, Sanders, Anne-Marthe, Sando, Sigrid B., Schmaal, Lianne, Schofield, Peter R., Schork, Andrew J., Schumann, Gunter, Shin, Jean, Shumskaya, Elena, Sisodiya, Sanjay, Steen, Vidar M., Stein, Dan J., Steinberg, Stacy, Strike, Lachlan, Teumer, Alexander, Thalamuthu, Anbu, Tordesillas-Gutierrez, Diana, Turner, Jessica, Ueland, Torill, Uhlmann, Anne, Ulfarsson, Magnus O., van ’t Ent, Dennis, van der Meer, Dennis, van Haren, Neeltje E. M., Vaskinn, Anja, Vassos, Evangelos, Walters, G. Bragi, Wang, Yunpeng, Wen, Wei, Whelan, Christopher D., Wittfeld, Katharina, Wright, Margie, Yamamori, Hidenaga, Zayats, Tetyana, Agartz, Ingrid, Westlye, Lars T., Jacquemont, Sébastien, Djurovic, Srdjan, Stefánsson, Hreinn, Stefánsson, Kári, Thompson, Paul, and Andreassen, Ole A.
Abstract: Prior to and following the publication of this article the authors noted that the complete list of authors was not included in the main article and was only present in Supplementary Table 1. The author list in the original article has now been updated to include all authors, and Supplementary Table 1 has been removed. All other supplementary files have now been updated accordingly. Furthermore, in Table 1 of this Article, the replication cohort for the row Close relative in data set, n(%) was incorrect. All values have now been corrected to 0(0%). The publishers would like to apologise for this error and the inconvenience it may have caused.
Published: 2020
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209. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Author: Sønderby, Ida E, Gústafsson, Ómar, Doan, Nhat Trung, Hibar, Derrek P, Martin-Brevet, Sandra, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Andersson, Michael, Armstrong, Nicola J, Bernard, Manon, Blackburn, Nicholas, Blangero, John, Boomsma, Dorret I, Bralten, Janita, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M, Bülow, Robin, Calhoun, Vince, Caspers, Svenja, Cavalleri, Gianpiero, Chen, Chi-Hua, Cichon, Sven, Ciufolini, Simone, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Dale, Anders M, Dalvie, Shareefa, Dazzan, Paola, de Geus, Eco J C, de Zubicaray, Greig I., de Zwarte, Sonja M. C., Delanty, Norman, den Braber, Anouk, Desrivières, Sylvane, Donohoe, Gary, Draganski, Bogdan, Ehrlich, Stefan, Espeseth, Thomas, Fisher, Simon E, Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Glahn, David C, Grabe, Hans, Groenewold, Nynke A., Haavik, Jan, Håberg, Asta, Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Heinz, Andreas, Hillegers, Manon H. J., Hoffmann, Per, Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E, Ikeda, Masashi, Jahanshad, Neda, Jernigan, Terry, Jockwitz, Christiane, Johansson, Stefan, Jonsdottir, Gudrun A, Jönsson, Erik G, Kahn, Rene, Kaufmann, Tobias, Kelly, Sinead, Kikuchi, Masataka, Knowles, Emma E M, Kolskår, Knut K, Kwok, John B, Hellard, Stephanie Le, Leu, Costin, Liu, Jingyu, Lundervold, Astri J, Lundervold, Arvid, Martin, Nicholas G., Mather, Karen, Mathias, Samuel R., McCormack, Mark, McMahon, Katie L., McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Mühleisen, Thomas W, Murray, Robin, Nordvik, Jan E, Nyberg, Lars, Olde Loohuis, Loes M, Ophoff, Roel, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda, Peralta, Juan M, Pike, Bruce, Prieto, Carlos, Pudas, Sara, Quinlan, Erin, Quintana, Daniel S, Reinbold, Céline S, Marques, Tiago Reis, Reymond, Alexandre, Richard, Genevieve, Rodriguez-Herreros, Borja, Roiz-Santiañez, Roberto, Rokicki, Jarek, Rucker, James, Sachdev, Perminder, Sanders, Anne-Marthe, Sando, Sigrid B, Schmaal, Lianne, Schofield, Peter R, Schork, Andrew J., Schumann, Gunter, Shin, Jean, Shumskaya, Elena, Sisodiya, Sanjay, Steen, Vidar M, Stein, Dan J, Steinberg, Stacy, Strike, Lachlan, Teumer, Alexander, Thalamuthu, Anbu, Tordesillas-Gutierrez, Diana, Turner, Jessica, Ueland, Torill, Uhlmann, Anne, Ulfarsson, Magnus O., van ’t Ent, Dennis, van der Meer, Dennis, van Haren, Neeltje E. M., Vaskinn, Anja, Vassos, Evangelos, Walters, G. Bragi, Wang, Yunpeng, Wen, Wei, Whelan, Christopher D, Wittfeld, Katharina, Wright, Margie, Yamamori, Hidenaga, Zayats, Tetyana, Agartz, Ingrid, Westlye, Lars T, Jacquemont, Sébastien, Djurovic, Srdjan, Stefánsson, Hreinn, Stefánsson, Kári, Thompson, Paul, and Andreassen, Ole A.
Abstract: Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β= −0.71 to −1.37; P< 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β= −0.95, P= 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P= 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
Published: 2020
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210. Suicide Ideation and Behavior as Risk Factors for Subsequent Suicide in Schizophrenia: A Nested Case-Control Study.

Author: Clapham, Eric, Bodén, Robert, Brandt, Lena, Jönsson, Erik G., Bahmanyar, Shahram, Ekbom, Anders, Ösby, Urban, and Reutfors, Johan
Subjects: SUICIDE risk factors, SUICIDE, RISK-taking behavior, SUICIDAL behavior, CASE-control method
Abstract: Objective: To investigate suicide ideation and behavior as risk factors for suicide in schizophrenia during varying time periods.Method: Cases were 84 patients who died by suicide within 5 years from diagnosis in a source population of patients discharged for the first time from psychiatric hospitals in Stockholm County, Sweden, with a schizophrenia spectrum diagnosis. One control was individually matched with each suicide case. Data were retrieved from clinical records in a blind fashion. Thoughts of death, thoughts of suicide, suicide plan, and suicide attempt during varying time periods were investigated as risk factors for subsequent completed suicide.Results: In adjusted analyses, thoughts of suicide, suicide plan, and suicide attempt were significantly associated with subsequent completed suicide in the following year. The highest suicide risk was found within a year following suicide attempt (adjusted OR 9.9, 95% confidence interval 2.5-39.0). The association between suicide ideation and behavior and subsequent suicide declined over time.Conclusions: Several types of suicide ideation and behavior were associated with suicide, and the association was stronger for suicidal behavior. The clinical significance of suicidal communication appears highest during the following month or/and year. Many suicides occurred without recorded short-term suicidal communication. [ABSTRACT FROM AUTHOR]
Published: 2019
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211. Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.

Author: Alnæs, Dag, Kaufmann, Tobias, van der Meer, Dennis, Córdova-Palomera, Aldo, Rokicki, Jaroslav, Moberget, Torgeir, Bettella, Francesco, Agartz, Ingrid, Barch, Deanna M., Bertolino, Alessandro, Brandt, Christine L., Cervenka, Simon, Djurovic, Srdjan, Doan, Nhat Trung, Eisenacher, Sarah, Fatouros-Bergman, Helena, Flyckt, Lena, Di Giorgio, Annabella, Haatveit, Beathe, and Jönsson, Erik G.
Subjects: FRONTOTEMPORAL lobar degeneration, 22Q11 deletion syndrome, SCHIZOPHRENIA, ECOLOGICAL disturbances, GRAFT versus host disease, MAGNETIC resonance imaging, GENOTYPE-environment interaction
Abstract: Importance: Between-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature.Objectives: To compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls.Design, Setting, and Participants: This case-control and polygenic risk analysis compared MRI-derived cortical thickness and subcortical volumes between healthy controls and patients with schizophrenia across 16 cohorts and tested for associations between PRS and MRI features in a control cohort from the UK Biobank. Data were collected from October 27, 2004, through April 12, 2018, and analyzed from December 3, 2017, through August 1, 2018.Main Outcomes and Measures: Mean and dispersion parameters were estimated using double generalized linear models. Vertex-wise analysis was used to assess cortical thickness, and regions-of-interest analyses were used to assess total cortical volume, total surface area, and white matter, subcortical, and hippocampal subfield volumes. Follow-up analyses included within-sample analysis, test of robustness of the PRS threshold, population covariates, outlier removal, and control for image quality.Results: A comparison of 1151 patients with schizophrenia (mean [SD] age, 33.8 [10.6] years; 68.6% male [n = 790] and 31.4% female [n = 361]) with 2010 healthy controls (mean [SD] age, 32.6 [10.4] years; 56.0% male [n = 1126] and 44.0% female [n = 884]) revealed higher heterogeneity in schizophrenia for cortical thickness and area (t = 3.34), cortical (t = 3.24) and ventricle (t range, 3.15-5.78) volumes, and hippocampal subfields (t range, 2.32-3.55). In the UK Biobank sample of 12 490 participants (mean [SD] age, 55.9 [7.5] years; 48.2% male [n = 6025] and 51.8% female [n = 6465]), higher PRS was associated with thinner frontal and temporal cortices and smaller left CA2/3 (t = -3.00) but was not significantly associated with dispersion.Conclusions and Relevance: This study suggests that schizophrenia is associated with substantial brain structural heterogeneity beyond the mean differences. These findings may reflect higher sensitivity to environmental and genetic perturbations in patients, supporting the heterogeneous nature of schizophrenia. A higher PRS was associated with thinner frontotemporal cortices and smaller hippocampal subfield volume, but not heterogeneity. This finding suggests that brain variability in schizophrenia results from interactions between environmental and genetic factors that are not captured by the PRS. Factors contributing to heterogeneity in frontotemporal cortices and hippocampus are key to furthering our understanding of how genetic and environmental factors shape brain biology in schizophrenia. [ABSTRACT FROM AUTHOR]
Published: 2019
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212. Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia

Author: Comasco, Erika, Vumma, Ravi, Toffoletto, Simone, Johansson, Jessica, Flyckt, Lena, Lewander, Tommy, Oreland, Lars, Bjerkenstedt, Lars, Andreou, Dimitrios, Söderman, Erik, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G., Venizelos, Nikolaos, Comasco, Erika, Vumma, Ravi, Toffoletto, Simone, Johansson, Jessica, Flyckt, Lena, Lewander, Tommy, Oreland, Lars, Bjerkenstedt, Lars, Andreou, Dimitrios, Söderman, Erik, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G., and Venizelos, Nikolaos
Abstract: Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5 /LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Moreover, the involvement of the different isoforms of the system in tyrosine uptake and LAT1 tyrosine kinetics were studied in fibroblast cell lines of 10 patients with schizophrenia and 10 healthy controls. The results provide suggestive evidence of individual vulnerability to schizophrenia related to the LAT1 SNP rs9936204 genotype. A number of SNPs were nominally associated with CSF HVA and MHPG concentrations but did not survive correction for multiple testing. The LAT1 isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters ( maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 isoform) did not differ between patients with schizophrenia and controls. The present genetic findings call for independent replication in larger samples, while the functional study seems to exclude a role of LAT1 in the aberrant transport of tyrosine in fibroblasts of patients with schizophrenia.
Published: 2016
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213. Suicide risk and antipsychotic side effects in schizophrenia : nested case-control study.

Author: Reutfors, Johan, Clapham, Eric, Bahmanyar, Shahram, Brandt, Lena, Jönsson, Erik G, Ekbom, Anders, Bodén, Robert, Ösby, Urban, Reutfors, Johan, Clapham, Eric, Bahmanyar, Shahram, Brandt, Lena, Jönsson, Erik G, Ekbom, Anders, Bodén, Robert, and Ösby, Urban
Abstract: OBJECTIVE: This study explores suicide risk in schizophrenia in relation to side effects from antipsychotic medication. METHODS: Among patients with a first clinical discharge diagnosis of schizophrenia or schizoaffective disorder in Stockholm County between 1984 and 2000 (n = 4000), those who died by suicide within 5 years from diagnosis were defined as cases (n = 84; 54% male). For each case, one individually matched control was identified from the same population. Information on antipsychotic side effects, including extrapyramidal symptoms (EPS) and akathisia, as well as prescriptions of anticholinergic medication, was retrieved from clinical records in a blinded fashion. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) of the association between suicide and side effects as well as anticholinergic medication were estimated using conditional logistic regression. RESULTS: A lower suicide risk was found in patients with a history of EPS (aOR 0.33, 95% CI 0.12-0.94). There was no statistically significant association between akathisia or anticholinergic medication use and the suicide risk. CONCLUSIONS: A lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients.
Published: 2016
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214. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, Thompson, Paul M, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, and Thompson, Paul M
Published: 2016

215. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Onderzoeksgroep 4, Brain, Risico & Preventie Ond., Onderzoeksgroep 2, Neurogenetica, Onderzoeksgroep 1, Affectieve & Psychotische Med., ZL Cerebrovasculaire Ziekten Medisch, Onderzoek, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, Thompson, Paul M, Onderzoeksgroep 4, Brain, Risico & Preventie Ond., Onderzoeksgroep 2, Neurogenetica, Onderzoeksgroep 1, Affectieve & Psychotische Med., ZL Cerebrovasculaire Ziekten Medisch, Onderzoek, Adams, Hieab H H, Hibar, Derrek P, Chouraki, Vincent, Stein, Jason L, Nyquist, Paul A, Rentería, Miguel E, Trompet, Stella, Arias-Vasquez, Alejandro, Seshadri, Sudha, Desrivières, Sylvane, Beecham, Ashley H, Jahanshad, Neda, Wittfeld, Katharina, Van der Lee, Sven J, Abramovic, Lucija, Alhusaini, Saud, Amin, Najaf, Andersson, Micael, Arfanakis, Konstantinos, Aribisala, Benjamin S, Armstrong, Nicola J, Athanasiu, Lavinia, Axelsson, Tomas, Beiser, Alexa, Bernard, Manon, Bis, Joshua C, Blanken, Laura M E, Blanton, Susan H, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brickman, Adam M, Carmichael, Owen, Chakravarty, M Mallar, Chauhan, Ganesh, Chen, Qiang, Ching, Christopher R K, Cuellar-Partida, Gabriel, Braber, Anouk Den, Doan, Nhat Trung, Ehrlich, Stefan, Filippi, Irina, Ge, Tian, Giddaluru, Sudheer, Goldman, Aaron L, Gottesman, Rebecca F, Greven, Corina U, Grimm, Oliver, Griswold, Michael E, Guadalupe, Tulio, Hass, Johanna, Haukvik, Unn K, Hilal, Saima, Hofer, Edith, Hoehn, David, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kasperaviciute, Dalia, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Liao, Jiemin, Liewald, David C M, Lopez, Lorna M, Luciano, Michelle, Macare, Christine, Marquand, Andre, Matarin, Mar, Mather, Karen A, Mattheisen, Manuel, Mazoyer, Bernard, McKay, David R, McWhirter, Rebekah, Milaneschi, Yuri, Mirza-Schreiber, Nazanin, Muetzel, Ryan L, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, Loohuis, Loes M Olde, Oosterlaan, Jaap, Papmeyer, Martina, Pappa, Irene, Pirpamer, Lukas, Pudas, Sara, Pütz, Benno, Rajan, Kumar B, Ramasamy, Adaikalavan, Richards, Jennifer S, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rommelse, Nanda, Rose, Emma J, Royle, Natalie A, Rundek, Tatjana, Sämann, Philipp G, Satizabal, Claudia L, Schmaal, Lianne, Schork, Andrew J, Shen, Li, Shin, Jean, Shumskaya, Elena, Smith, Albert V, Sprooten, Emma, Strike, Lachlan T, Teumer, Alexander, Thomson, Russell, Tordesillas-Gutierrez, Diana, Toro, Roberto, Trabzuni, Daniah, Vaidya, Dhananjay, Van der Grond, Jeroen, Van der Meer, Dennis, Van Donkelaar, Marjolein M J, Van Eijk, Kristel R, Van Erp, Theo G M, Van Rooij, Daan, Walton, Esther, Westlye, Lars T, Whelan, Christopher D, Windham, Beverly G, Winkler, Anderson M, Woldehawariat, Girma, Wolf, Christiane, Wolfers, Thomas, Xu, Bing, Yanek, Lisa R, Yang, Jingyun, Zijdenbos, Alex, Zwiers, Marcel P, Agartz, Ingrid, Aggarwal, Neelum T, Almasy, Laura, Ames, David, Amouyel, Philippe, Andreassen, Ole A, Arepalli, Sampath, Assareh, Amelia A, Barral, Sandra, Bastin, Mark E, Becker, Diane M, Becker, James T, Bennett, David A, Blangero, John, van Bokhoven, Hans, Boomsma, Dorret I, Brodaty, Henry, Brouwer, Rachel M, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Bulayeva, Kazima B, Cahn, Wiepke, Calhoun, Vince D, Cannon, Dara M, Cavalleri, Gianpiero L, Chen, Christopher, Cheng, Ching-Yu, Cichon, Sven, Cookson, Mark R, Corvin, Aiden, Crespo-Facorro, Benedicto, Curran, Joanne E, Czisch, Michael, Dale, Anders M, Davies, Gareth E, De Geus, Eco J C, De Jager, Philip L, de Zubicaray, Greig I, Delanty, Norman, Depondt, Chantal, DeStefano, Anita L, Dillman, Allissa, Djurovic, Srdjan, Donohoe, Gary, Drevets, Wayne C, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Espeseth, Thomas, Evans, Denis A, Fedko, Iryna O, Fernández, Guillén, Ferrucci, Luigi, Fisher, Simon E, Fleischman, Debra A, Ford, Ian, Foroud, Tatiana M, Fox, Peter T, Francks, Clyde, Fukunaga, Masaki, Gibbs, J Raphael, Glahn, David C, Gollub, Randy L, Göring, Harald H H, Grabe, Hans J, Green, Robert C, Gruber, Oliver, Gudnason, Vilmundur, Guelfi, Sebastian, Hansell, Narelle K, Hardy, John, Hartman, Catharina A, Hashimoto, Ryota, Hegenscheid, Katrin, Heinz, Andreas, Le Hellard, Stephanie, Hernandez, Dena G, Heslenfeld, Dirk J, Ho, Beng-Choon, Hoekstra, Pieter J, Hoffmann, Wolfgang, Hofman, Albert, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Hottenga, Jouke-Jan, Pol, Hilleke E Hulshoff, Ikeda, Masashi, Ikram, M Kamran, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Jönsson, Erik G, Jukema, J Wouter, Kahn, René S, Kanai, Ryota, Kloszewska, Iwona, Knopman, David S, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Lemaître, Hervé, Liu, Xinmin, Longo, Dan L, Longstreth, W T, Lopez, Oscar L, Lovestone, Simon, Martinez, Oliver, Martinot, Jean-Luc, Mattay, Venkata S, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McMahon, Francis J, Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Mohnke, Sebastian, Montgomery, Grant W, Morris, Derek W, Mosley, Thomas H, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Nalls, Michael A, Nauck, Matthias, Nichols, Thomas E, Niessen, Wiro J, Nöthen, Markus M, Nyberg, Lars, Ohi, Kazutaka, Olvera, Rene L, Ophoff, Roel A, Pandolfo, Massimo, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Pike, G Bruce, Potkin, Steven G, Psaty, Bruce M, Reppermund, Simone, Rietschel, Marcella, Roffman, Joshua L, Romanczuk-Seiferth, Nina, Rotter, Jerome I, Ryten, Mina, Sacco, Ralph L, Sachdev, Perminder S, Saykin, Andrew J, Schmidt, Reinhold, Schofield, Peter R, Sigurdsson, Sigurdur, Simmons, Andy, Singleton, Andrew, Sisodiya, Sanjay M, Smith, Colin, Smoller, Jordan W, Soininen, Hilkka, Srikanth, Velandai, Steen, Vidar M, Stott, David J, Sussmann, Jessika E, Thalamuthu, Anbupalam, Tiemeier, Henning, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Tzourio, Christophe, Uitterlinden, Andre G, Hernández, Maria C Valdés, Van der Brug, Marcel, Van der Lugt, Aad, Van der Wee, Nic J A, Van Duijn, Cornelia M, Van Haren, Neeltje E M, Van T Ent, Dennis, Van Tol, Marie-Jose, Vardarajan, Badri N, Veltman, Dick J, Vernooij, Meike W, Völzke, Henry, Walter, Henrik, Wardlaw, Joanna M, Wassink, Thomas H, Weale, Michael E, Weinberger, Daniel R, Weiner, Michael W, Wen, Wei, Westman, Eric, White, Tonya, Wong, Tien Y, Wright, Clinton B, Zielke, H Ronald, Zonderman, Alan B, Deary, Ian J, DeCarli, Charles, Schmidt, Helena, Martin, Nicholas G, De Craen, Anton J M, Wright, Margaret J, Launer, Lenore J, Schumann, Gunter, Fornage, Myriam, Franke, Barbara, Debette, Stéphanie, Medland, Sarah E, Ikram, M Arfan, and Thompson, Paul M
Published: 2016

216. CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis

Author: Carlborg, Andreas, Jokinen, Jussi, Jönsson, Erik G., Erhardt, Sophie, and Nordström, Peter
Published: 2013
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217. Consistent Functional Connectivity Alterations in Schizophrenia Spectrum Disorder: A Multisite Study

Author: Skåtun, Kristina C., primary, Kaufmann, Tobias, additional, Doan, Nhat Trung, additional, Alnæs, Dag, additional, Córdova-Palomera, Aldo, additional, Jönsson, Erik G., additional, Fatouros-Bergman, Helena, additional, Flyckt, Lena, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Agartz, Ingrid, additional, and Westlye, Lars T., additional
Published: 2016
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218. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Author: Guadalupe, Tulio, primary, Mathias, Samuel R., additional, vanErp, Theo G. M., additional, Whelan, Christopher D., additional, Zwiers, Marcel P., additional, Abe, Yoshinari, additional, Abramovic, Lucija, additional, Agartz, Ingrid, additional, Andreassen, Ole A., additional, Arias-Vásquez, Alejandro, additional, Aribisala, Benjamin S., additional, Armstrong, Nicola J., additional, Arolt, Volker, additional, Artiges, Eric, additional, Ayesa-Arriola, Rosa, additional, Baboyan, Vatche G., additional, Banaschewski, Tobias, additional, Barker, Gareth, additional, Bastin, Mark E., additional, Baune, Bernhard T., additional, Blangero, John, additional, Bokde, Arun L.W., additional, Boedhoe, Premika S.W., additional, Bose, Anushree, additional, Brem, Silvia, additional, Brodaty, Henry, additional, Bromberg, Uli, additional, Brooks, Samantha, additional, Büchel, Christian, additional, Buitelaar, Jan, additional, Calhoun, Vince D., additional, Cannon, Dara M., additional, Cattrell, Anna, additional, Cheng, Yuqi, additional, Conrod, Patricia J., additional, Conzelmann, Annette, additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Crivello, Fabrice, additional, Dannlowski, Udo, additional, de Zubicaray, Greig I., additional, de Zwarte, Sonja M.C., additional, Deary, Ian J., additional, Desrivières, Sylvane, additional, Doan, Nhat Trung, additional, Donohoe, Gary, additional, Dørum, Erlend S., additional, Ehrlich, Stefan, additional, Espeseth, Thomas, additional, Fernández, Guillén, additional, Flor, Herta, additional, Fouche, Jean-Paul, additional, Frouin, Vincent, additional, Fukunaga, Masaki, additional, Gallinat, Jürgen, additional, Garavan, Hugh, additional, Gill, Michael, additional, Suarez, Andrea Gonzalez, additional, Gowland, Penny, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Hagenaars, Saskia, additional, Hashimoto, Ryota, additional, Hauser, Tobias U., additional, Heinz, Andreas, additional, Hibar, Derrek P., additional, Hoekstra, Pieter J., additional, Hoogman, Martine, additional, Howells, Fleur M., additional, Hu, Hao, additional, Hulshoff Pol, Hilleke E., additional, Huyser, Chaim, additional, Ittermann, Bernd, additional, Jahanshad, Neda, additional, Jönsson, Erik G., additional, Jurk, Sarah, additional, Kahn, Rene S., additional, Kelly, Sinead, additional, Kraemer, Bernd, additional, Kugel, Harald, additional, Kwon, Jun Soo, additional, Lemaitre, Herve, additional, Lesch, Klaus-Peter, additional, Lochner, Christine, additional, Luciano, Michelle, additional, Marquand, Andre F., additional, Martin, Nicholas G., additional, Martínez-Zalacaín, Ignacio, additional, Martinot, Jean-Luc, additional, Mataix-Cols, David, additional, Mather, Karen, additional, McDonald, Colm, additional, McMahon, Katie L., additional, Medland, Sarah E., additional, Menchón, José M., additional, Morris, Derek W., additional, Mothersill, Omar, additional, Maniega, Susana Munoz, additional, Mwangi, Benson, additional, Nakamae, Takashi, additional, Nakao, Tomohiro, additional, Narayanaswaamy, Janardhanan C., additional, Nees, Frauke, additional, Nordvik, Jan E., additional, Onnink, A. Marten H., additional, Opel, Nils, additional, Ophoff, Roel, additional, Paillère Martinot, Marie-Laure, additional, Papadopoulos Orfanos, Dimitri, additional, Pauli, Paul, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Reddy, Janardhan YC., additional, Renteria, Miguel E., additional, Roiz-Santiáñez, Roberto, additional, Roos, Annerine, additional, Royle, Natalie A., additional, Sachdev, Perminder, additional, Sánchez-Juan, Pascual, additional, Schmaal, Lianne, additional, Schumann, Gunter, additional, Shumskaya, Elena, additional, Smolka, Michael N., additional, Soares, Jair C., additional, Soriano-Mas, Carles, additional, Stein, Dan J., additional, Strike, Lachlan T., additional, Toro, Roberto, additional, Turner, Jessica A., additional, Tzourio-Mazoyer, Nathalie, additional, Uhlmann, Anne, additional, Hernández, Maria Valdés, additional, van den Heuvel, Odile A., additional, van der Meer, Dennis, additional, van Haren, Neeltje E.M ., additional, Veltman, Dick J., additional, Venkatasubramanian, Ganesan, additional, Vetter, Nora C., additional, Vuletic, Daniella, additional, Walitza, Susanne, additional, Walter, Henrik, additional, Walton, Esther, additional, Wang, Zhen, additional, Wardlaw, Joanna, additional, Wen, Wei, additional, Westlye, Lars T., additional, Whelan, Robert, additional, Wittfeld, Katharina, additional, Wolfers, Thomas, additional, Wright, Margaret J., additional, Xu, Jian, additional, Xu, Xiufeng, additional, Yun, Je-Yeon, additional, Zhao, JingJing, additional, Franke, Barbara, additional, Thompson, Paul M., additional, Glahn, David C., additional, Mazoyer, Bernard, additional, Fisher, Simon E., additional, and Francks, Clyde, additional
Published: 2016
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219. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author: Adams, Hieab H H, primary, Hibar, Derrek P, additional, Chouraki, Vincent, additional, Stein, Jason L, additional, Nyquist, Paul A, additional, Rentería, Miguel E, additional, Trompet, Stella, additional, Arias-Vasquez, Alejandro, additional, Seshadri, Sudha, additional, Desrivières, Sylvane, additional, Beecham, Ashley H, additional, Jahanshad, Neda, additional, Wittfeld, Katharina, additional, Van der Lee, Sven J, additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Amin, Najaf, additional, Andersson, Micael, additional, Arfanakis, Konstantinos, additional, Aribisala, Benjamin S, additional, Armstrong, Nicola J, additional, Athanasiu, Lavinia, additional, Axelsson, Tomas, additional, Beiser, Alexa, additional, Bernard, Manon, additional, Bis, Joshua C, additional, Blanken, Laura M E, additional, Blanton, Susan H, additional, Bohlken, Marc M, additional, Boks, Marco P, additional, Bralten, Janita, additional, Brickman, Adam M, additional, Carmichael, Owen, additional, Chakravarty, M Mallar, additional, Chauhan, Ganesh, additional, Chen, Qiang, additional, Ching, Christopher R K, additional, Cuellar-Partida, Gabriel, additional, Braber, Anouk Den, additional, Doan, Nhat Trung, additional, Ehrlich, Stefan, additional, Filippi, Irina, additional, Ge, Tian, additional, Giddaluru, Sudheer, additional, Goldman, Aaron L, additional, Gottesman, Rebecca F, additional, Greven, Corina U, additional, Grimm, Oliver, additional, Griswold, Michael E, additional, Guadalupe, Tulio, additional, Hass, Johanna, additional, Haukvik, Unn K, additional, Hilal, Saima, additional, Hofer, Edith, additional, Hoehn, David, additional, Holmes, Avram J, additional, Hoogman, Martine, additional, Janowitz, Deborah, additional, Jia, Tianye, additional, Kasperaviciute, Dalia, additional, Kim, Sungeun, additional, Klein, Marieke, additional, Kraemer, Bernd, additional, Lee, Phil H, additional, Liao, Jiemin, additional, Liewald, David C M, additional, Lopez, Lorna M, additional, Luciano, Michelle, additional, Macare, Christine, additional, Marquand, Andre, additional, Matarin, Mar, additional, Mather, Karen A, additional, Mattheisen, Manuel, additional, Mazoyer, Bernard, additional, McKay, David R, additional, McWhirter, Rebekah, additional, Milaneschi, Yuri, additional, Mirza-Schreiber, Nazanin, additional, Muetzel, Ryan L, additional, Maniega, Susana Muñoz, additional, Nho, Kwangsik, additional, Nugent, Allison C, additional, Loohuis, Loes M Olde, additional, Oosterlaan, Jaap, additional, Papmeyer, Martina, additional, Pappa, Irene, additional, Pirpamer, Lukas, additional, Pudas, Sara, additional, Pütz, Benno, additional, Rajan, Kumar B, additional, Ramasamy, Adaikalavan, additional, Richards, Jennifer S, additional, Risacher, Shannon L, additional, Roiz-Santiañez, Roberto, additional, Rommelse, Nanda, additional, Rose, Emma J, additional, Royle, Natalie A, additional, Rundek, Tatjana, additional, Sämann, Philipp G, additional, Satizabal, Claudia L, additional, Schmaal, Lianne, additional, Schork, Andrew J, additional, Shen, Li, additional, Shin, Jean, additional, Shumskaya, Elena, additional, Smith, Albert V, additional, Sprooten, Emma, additional, Strike, Lachlan T, additional, Teumer, Alexander, additional, Thomson, Russell, additional, Tordesillas-Gutierrez, Diana, additional, Toro, Roberto, additional, Trabzuni, Daniah, additional, Vaidya, Dhananjay, additional, Van der Grond, Jeroen, additional, Van der Meer, Dennis, additional, Van Donkelaar, Marjolein M J, additional, Van Eijk, Kristel R, additional, Van Erp, Theo G M, additional, Van Rooij, Daan, additional, Walton, Esther, additional, Westlye, Lars T, additional, Whelan, Christopher D, additional, Windham, Beverly G, additional, Winkler, Anderson M, additional, Woldehawariat, Girma, additional, Wolf, Christiane, additional, Wolfers, Thomas, additional, Xu, Bing, additional, Yanek, Lisa R, additional, Yang, Jingyun, additional, Zijdenbos, Alex, additional, Zwiers, Marcel P, additional, Agartz, Ingrid, additional, Aggarwal, Neelum T, additional, Almasy, Laura, additional, Ames, David, additional, Amouyel, Philippe, additional, Andreassen, Ole A, additional, Arepalli, Sampath, additional, Assareh, Amelia A, additional, Barral, Sandra, additional, Bastin, Mark E, additional, Becker, Diane M, additional, Becker, James T, additional, Bennett, David A, additional, Blangero, John, additional, van Bokhoven, Hans, additional, Boomsma, Dorret I, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Brunner, Han G, additional, Buckner, Randy L, additional, Buitelaar, Jan K, additional, Bulayeva, Kazima B, additional, Cahn, Wiepke, additional, Calhoun, Vince D, additional, Cannon, Dara M, additional, Cavalleri, Gianpiero L, additional, Chen, Christopher, additional, Cheng, Ching-Yu, additional, Cichon, Sven, additional, Cookson, Mark R, additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Curran, Joanne E, additional, Czisch, Michael, additional, Dale, Anders M, additional, Davies, Gareth E, additional, De Geus, Eco J C, additional, De Jager, Philip L, additional, de Zubicaray, Greig I, additional, Delanty, Norman, additional, Depondt, Chantal, additional, DeStefano, Anita L, additional, Dillman, Allissa, additional, Djurovic, Srdjan, additional, Donohoe, Gary, additional, Drevets, Wayne C, additional, Duggirala, Ravi, additional, Dyer, Thomas D, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Evans, Denis A, additional, Fedko, Iryna O, additional, Fernández, Guillén, additional, Ferrucci, Luigi, additional, Fisher, Simon E, additional, Fleischman, Debra A, additional, Ford, Ian, additional, Foroud, Tatiana M, additional, Fox, Peter T, additional, Francks, Clyde, additional, Fukunaga, Masaki, additional, Gibbs, J Raphael, additional, Glahn, David C, additional, Gollub, Randy L, additional, Göring, Harald H H, additional, Grabe, Hans J, additional, Green, Robert C, additional, Gruber, Oliver, additional, Gudnason, Vilmundur, additional, Guelfi, Sebastian, additional, Hansell, Narelle K, additional, Hardy, John, additional, Hartman, Catharina A, additional, Hashimoto, Ryota, additional, Hegenscheid, Katrin, additional, Heinz, Andreas, additional, Le Hellard, Stephanie, additional, Hernandez, Dena G, additional, Heslenfeld, Dirk J, additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J, additional, Hoffmann, Wolfgang, additional, Hofman, Albert, additional, Holsboer, Florian, additional, Homuth, Georg, additional, Hosten, Norbert, additional, Hottenga, Jouke-Jan, additional, Hulshoff Pol, Hilleke E, additional, Ikeda, Masashi, additional, Ikram, M Kamran, additional, Jack, Clifford R, additional, Jenkinson, Mark, additional, Johnson, Robert, additional, Jönsson, Erik G, additional, Jukema, J Wouter, additional, Kahn, René S, additional, Kanai, Ryota, additional, Kloszewska, Iwona, additional, Knopman, David S, additional, Kochunov, Peter, additional, Kwok, John B, additional, Lawrie, Stephen M, additional, Lemaître, Hervé, additional, Liu, Xinmin, additional, Longo, Dan L, additional, Longstreth, W T, additional, Lopez, Oscar L, additional, Lovestone, Simon, additional, Martinez, Oliver, additional, Martinot, Jean-Luc, additional, Mattay, Venkata S, additional, McDonald, Colm, additional, McIntosh, Andrew M, additional, McMahon, Katie L, additional, McMahon, Francis J, additional, Mecocci, Patrizia, additional, Melle, Ingrid, additional, Meyer-Lindenberg, Andreas, additional, Mohnke, Sebastian, additional, Montgomery, Grant W, additional, Morris, Derek W, additional, Mosley, Thomas H, additional, Mühleisen, Thomas W, additional, Müller-Myhsok, Bertram, additional, Nalls, Michael A, additional, Nauck, Matthias, additional, Nichols, Thomas E, additional, Niessen, Wiro J, additional, Nöthen, Markus M, additional, Nyberg, Lars, additional, Ohi, Kazutaka, additional, Olvera, Rene L, additional, Ophoff, Roel A, additional, Pandolfo, Massimo, additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Penninx, Brenda W J H, additional, Pike, G Bruce, additional, Potkin, Steven G, additional, Psaty, Bruce M, additional, Reppermund, Simone, additional, Rietschel, Marcella, additional, Roffman, Joshua L, additional, Romanczuk-Seiferth, Nina, additional, Rotter, Jerome I, additional, Ryten, Mina, additional, Sacco, Ralph L, additional, Sachdev, Perminder S, additional, Saykin, Andrew J, additional, Schmidt, Reinhold, additional, Schofield, Peter R, additional, Sigurdsson, Sigurdur, additional, Simmons, Andy, additional, Singleton, Andrew, additional, Sisodiya, Sanjay M, additional, Smith, Colin, additional, Smoller, Jordan W, additional, Soininen, Hilkka, additional, Srikanth, Velandai, additional, Steen, Vidar M, additional, Stott, David J, additional, Sussmann, Jessika E, additional, Thalamuthu, Anbupalam, additional, Tiemeier, Henning, additional, Toga, Arthur W, additional, Traynor, Bryan J, additional, Troncoso, Juan, additional, Turner, Jessica A, additional, Tzourio, Christophe, additional, Uitterlinden, Andre G, additional, Hernández, Maria C Valdés, additional, Van der Brug, Marcel, additional, Van der Lugt, Aad, additional, Van der Wee, Nic J A, additional, Van Duijn, Cornelia M, additional, Van Haren, Neeltje E M, additional, Van ′t Ent, Dennis, additional, Van Tol, Marie-Jose, additional, Vardarajan, Badri N, additional, Veltman, Dick J, additional, Vernooij, Meike W, additional, Völzke, Henry, additional, Walter, Henrik, additional, Wardlaw, Joanna M, additional, Wassink, Thomas H, additional, Weale, Michael E, additional, Weinberger, Daniel R, additional, Weiner, Michael W, additional, Wen, Wei, additional, Westman, Eric, additional, White, Tonya, additional, Wong, Tien Y, additional, Wright, Clinton B, additional, Zielke, H Ronald, additional, Zonderman, Alan B, additional, Deary, Ian J, additional, DeCarli, Charles, additional, Schmidt, Helena, additional, Martin, Nicholas G, additional, De Craen, Anton J M, additional, Wright, Margaret J, additional, Launer, Lenore J, additional, Schumann, Gunter, additional, Fornage, Myriam, additional, Franke, Barbara, additional, Debette, Stéphanie, additional, Medland, Sarah E, additional, Ikram, M Arfan, additional, and Thompson, Paul M, additional
Published: 2016
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220. Suicide risk and antipsychotic side effects in schizophrenia: nested case-control study

Author: Reutfors, Johan, primary, Clapham, Eric, additional, Bahmanyar, Shahram, additional, Brandt, Lena, additional, Jönsson, Erik G., additional, Ekbom, Anders, additional, Bodén, Robert, additional, and Ösby, Urban, additional
Published: 2016
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221. Personality traits in established schizophrenia: aspects of usability and differences between patients and controls using the Swedish universities Scales of Personality

Author: Fagerberg, Tomas, primary, Söderman, Erik, additional, Gustavsson, J. Petter, additional, Agartz, Ingrid, additional, and Jönsson, Erik G., additional
Published: 2016
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222. Associations between a locus downstream DRD1 gene and cerebrospinal fluid dopamine metabolite concentrations in psychosis

Author: Andreou, Dimitrios, primary, Söderman, Erik, additional, Axelsson, Tomas, additional, Sedvall, Göran C., additional, Terenius, Lars, additional, Agartz, Ingrid, additional, and Jönsson, Erik G., additional
Published: 2016
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223. Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia

Author: Comasco, Erika, primary, Vumma, Ravi, additional, Toffoletto, Simone, additional, Johansson, Jessica, additional, Flyckt, Lena, additional, Lewander, Tommy, additional, Oreland, Lars, additional, Bjerkenstedt, Lars, additional, Andreou, Dimitrios, additional, Söderman, Erik, additional, Terenius, Lars, additional, Agartz, Ingrid, additional, Jönsson, Erik G., additional, and Venizelos, Nikolaos, additional
Published: 2016
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224. Psychiatric and neurological disorders in late adolescence and risk of convictions for violent crime in men

Author: Moberg, Tomas, Stenbacka, Marlene, Tengström, Anders, Jönsson, Erik G, Nordström, Peter, Jokinen, Jussi, Moberg, Tomas, Stenbacka, Marlene, Tengström, Anders, Jönsson, Erik G, Nordström, Peter, and Jokinen, Jussi
Abstract: Background: The relationship between mental illness and violent crime is complex because of the involvement of many other confounding risk factors. In the present study, we analysed psychiatric and neurological disorders in relation to the risk of convictions for violent crime, taking into account early behavioural and socio-economic risk factors. Methods: The study population consisted of 49,398 Swedish men, who were thoroughly assessed at conscription for compulsory military service during the years 1969-1970 and followed in national crime registers up to 2006. Five diagnostic groups were analysed: anxiety-depression/neuroses, personality disorders, substance-related disorders, mental retardation and neurological conditions. In addition, eight confounders measured at conscription and based on the literature on violence risk assessment, were added to the analyses. The relative risks of convictions for violent crime during 35 years after conscription were examined in relation to psychiatric diagnoses and other risk factors at conscription, as measured by odds ratios (ORs) and confidence intervals (CIs) from bivariate and multivariate logistic regression analyses. Results: In the bivariate analyses there was a significant association between receiving a psychiatric diagnosis at conscription and a future conviction for violent crime (OR = 3.83, 95 % CI = 3.47-4.22), whereas no significant association between neurological conditions and future violent crime (OR = 1.03, 95 % CI = 0.48-2.21) was found. In the fully adjusted multivariate logistic regression model, mental retardation had the strongest association with future violent crime (OR = 3.60, 95 % CI = 2.73-4.75), followed by substance-related disorders (OR = 2.81, 95 % CI = 2.18-3.62), personality disorders (OR = 2.66, 95 % CI = 2.21-3.19) and anxiety-depression (OR = 1.29, 95 % CI = 1.07-1.55). Among the other risk factors, early behavioural problem had the strongest association with convictions for violent crime
Published: 2015
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225. Suicide Risk and Side Effects from Antipsychotics in Schizophrenia : A Nested Case-Control Study

Author: Reutfors, Johan, Bahmanyar, Shahram, Brandt, Lena, Clapham, Eric, Jönsson, Erik G., Boden, Robert, Ekbom, Anders, Osby, Urban, Reutfors, Johan, Bahmanyar, Shahram, Brandt, Lena, Clapham, Eric, Jönsson, Erik G., Boden, Robert, Ekbom, Anders, and Osby, Urban
Published: 2015

226. Genetic architecture of subcortical brain structures in 38,851 individuals

Author: Satizabal, Claudia L., Adams, Hieab H. H., Hibar, Derrek P., White, Charles C., Knol, Maria J., Stein, Jason L., Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V., Smith, Albert V., Bis, Joshua C., Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J., Yang, Jingyun, Yanek, Lisa R., Lee, Tom V., Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D., Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E., Kim, Sungeun, Hoehn, David, Armstrong, Nicola J., Chen, Qiang, Holmes, Avram J., den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K., Jones, Hannah J., Pike, G. Bruce, Stein, Dan J., Stevens, Allison, Bralten, Janita, Vernooij, Meike W., Harris, Tamara B., Filippi, Irina, Witte, A. Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H., Becker, James T., Doan, Nhat Trung, Hagenaars, Saskia P., Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M., Ames, David, Goldman, Aaron L., Lee, Phil H., Boomsma, Dorret I., Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M., Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M., Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E., Shin, Jean, Ipser, Jonathan C., Vinke, Louis N., Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K., Aribisala, Benjamin S., Schmidt, Helena, Strike, Lachlan T., Cheng, Ching-Yu, Risacher, Shannon L., Pütz, Benno, Fleischman, Debra A., Assareh, Amelia A., Mattay, Venkata S., Buckner, Randy L., Mecocci, Patrizia, Dale, Anders M., Cichon, Sven, Boks, Marco P., Matarin, Mar, Penninx, Brenda W. J. H., Calhoun, Vince D., Chakravarty, M. Mallar, Marquand, Andre F., Macare, Christine, Kharabian Masouleh, Shahrzad, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome I., Schork, Andrew J., Liewald, David C. M., de Zubicaray, Greig I., Wong, Tien Yin, Shen, Li, Sämann, Philipp G., Brodaty, Henry, Roffman, Joshua L., de Geus, Eco J. C., Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R., Cavalleri, Gianpiero L., van der Wee, Nic J. A., McIntosh, Andrew M., Gollub, Randy L., Bulayeva, Kazima B., Bernard, Manon, Richards, Jennifer S., Himali, Jayandra J., Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T., Valdés Hernández, Maria C., Hansell, Narelle K., van Erp, Theo G. M., Wolf, Christiane, Kwok, John B. J., Vellas, Bruno, Heinz, Andreas, Olde Loohuis, Loes M., Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R. K., Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M., Bastin, Mark E., Montgomery, Grant W., Foroud, Tatiana M., Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D., van Donkelaar, Marjolein M. J., Yang, Qiong, Hosten, Norbert, Green, Robert C, Thalamuthu, Anbupalam, Mohnke, Sebastian, Hulshoff Pol, Hilleke E., Lin, Honghuang, Jack, Clifford R., Schofield, Peter R., Mühleisen, Thomas W., Maillard, Pauline, Potkin, Steven G., Wen, Wei, Fletcher, Evan, Toga, Arthur W., Gruber, Oliver, Huentelman, Matthew, Davey Smith, George, Launer, Lenore J., Nyberg, Lars, Jönsson, Erik G., Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N., Uitterlinden, André G., Weinberger, Daniel R., Steen, Vidar M., Fedko, Iryna O., Groenewold, Nynke A., Niessen, Wiro J., Toro, Roberto, Tzourio, Christophe, Longstreth, William T., Ikram, M. Kamran, Smoller, Jordan W., van Tol, Marie-Jose, Sussmann, Jessika E., Paus, Tomas, Lemaître, Hervé, Schroeter, Matthias L., Mazoyer, Bernard, Andreassen, Ole A., Holsboer, Florian, Depondt, Chantal, Veltman, Dick J., Turner, Jessica A., Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J., McMahon, Katie L., Müller-Myhsok, Bertram, Brouwer, Rachel M., Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H., Cheung, Joshua W., Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P., Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G., Kanai, Ryota, Westman, Eric, Kahn, René S., Sisodiya, Sanjay M., White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G., Völzke, Henry, Wright, Margaret J., van ‘t Ent, Dennis, Nöthen, Markus M., Ophoff, Roel A., Buitelaar, Jan K., Fernández, Guillén, Sachdev, Perminder S., Rietschel, Marcella, van Haren, Neeltje E. M., Fisher, Simon E., Beiser, Alexa S., Francks, Clyde, Saykin, Andrew J., Mather, Karen A., Romanczuk-Seiferth, Nina, Hartman, Catharina A., DeStefano, Anita L., Heslenfeld, Dirk J., Weiner, Michael W., Walter, Henrik, Hoekstra, Pieter J., Nyquist, Paul A., Franke, Barbara, Bennett, David A., Grabe, Hans J., Johnson, Andrew D., Chen, Christopher, van Duijn, Cornelia M., Lopez, Oscar L., Fornage, Myriam, Wardlaw, Joanna M., Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L., Villringer, Arno, Debette, Stéphanie, Gudnason, Vilmundur, Medland, Sarah E., Shulman, Joshua M., Thompson, Paul M., Seshadri, Sudha, and Ikram, M. Arfan
Abstract: Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophilaorthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Published: 2019
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227. Common brain disorders are associated with heritable patterns of apparent aging of the brain

Author: Kaufmann, Tobias, van der Meer, Dennis, Doan, Nhat Trung, Schwarz, Emanuel, Lund, Martina J., Agartz, Ingrid, Alnæs, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Bettella, Francesco, Beyer, Mona K., Bøen, Erlend, Borgwardt, Stefan, Brandt, Christine L., Buitelaar, Jan, Celius, Elisabeth G., Cervenka, Simon, Conzelmann, Annette, Córdova-Palomera, Aldo, Dale, Anders M., de Quervain, Dominique J. F., Di Carlo, Pasquale, Djurovic, Srdjan, Dørum, Erlend S., Eisenacher, Sarah, Elvsåshagen, Torbjørn, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Haatveit, Beathe, Håberg, Asta K., Harbo, Hanne F., Hartman, Catharina A., Heslenfeld, Dirk, Hoekstra, Pieter J., Høgestøl, Einar A., Jernigan, Terry L., Jonassen, Rune, Jönsson, Erik G., Kirsch, Peter, Kłoszewska, Iwona, Kolskår, Knut K., Landrø, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Lovestone, Simon, Lundervold, Arvid, Lundervold, Astri J., Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Norbom, Linn B., Nordvik, Jan Egil, Nyberg, Lars, Oosterlaan, Jaap, Papalino, Marco, Papassotiropoulos, Andreas, Pauli, Paul, Pergola, Giulio, Persson, Karin, Richard, Geneviève, Rokicki, Jaroslav, Sanders, Anne-Marthe, Selbæk, Geir, Shadrin, Alexey A., Smeland, Olav B., Soininen, Hilkka, Sowa, Piotr, Steen, Vidar M., Tsolaki, Magda, Ulrichsen, Kristine M., Vellas, Bruno, Wang, Lei, Westman, Eric, Ziegler, Georg C., Zink, Mathias, Andreassen, Ole A., and Westlye, Lars T.
Abstract: Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
Published: 2019
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228. Population‐based identity‐by‐descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Author: Harold, Denise, Connolly, Siobhan, Riley, Brien P., Kendler, Kenneth S., McCarthy, Shane E., McCombie, William R., Richards, Alex, Owen, Michael J., O'Donovan, Michael C., Walters, James, Donnelly, Peter, Bates, Lesley, Barroso, Ines, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Deloukas, Panos, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S., Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Viswanathan, Ananth C., Wood, Nicholas W., Spencer, Chris C. A., Band, Gavin, Bellenguez, Céline, Freeman, Colin, Hellenthal, Garrett, Giannoulatou, Eleni, Hopkins, Lucinda, Pirinen, Matti, Pearson, Richard, Strange, Amy, Su, Zhan, Vukcevic, Damjan, Langford, Cordelia, Hunt, Sarah E., Edkins, Sarah, Gwilliam, Rhian, Blackburn, Hannah, Bumpstead, Suzannah J., Dronov, Serge, Gillman, Matthew, Gray, Emma, Hammond, Naomi, Jayakumar, Alagurevathi, McCann, Owen T., Liddle, Jennifer, Potter, Simon C., Ravindrarajah, Radhi, Ricketts, Michelle, Waller, Matthew, Weston, Paul, Widaa, Sara, Whittaker, Pamela, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T. R., Farh, Kai‐How, Holmans, Peter A., Lee, Phil, Bulik‐Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C. K., Chan, Ronald Y. L., Chen, Eric Y. H., Cheng, Wei, Cheung, Eric F. C., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott‐Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti‐Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kalaydjieva, Luba, Karachanak‐Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova‐Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee, Jimmy, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung‐Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K. E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam‐Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin‐Germeys, Inez, Müller‐Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina‐Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F. Anthony, Oh, Sang‐Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic‐Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon‐Cheong, Spencer, Chris C. A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T. Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H. M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H. R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, Clair, David St, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., O'Donovan, Michael C., Donohoe, Gary, Gill, Michael, Corvin, Aiden, and Morris, Derek W.
Abstract: Genome‐wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of large copy number variants, are difficult to detect with GWAS. Exome and genome sequencing, which have accelerated the study of rare variants, are expensive so alternative methods are needed to aid detection of rare variants. Here we re‐analyze an Irish schizophrenia GWAS dataset (n= 3,473) by performing identity‐by‐descent (IBD) mapping followed by exome sequencing of individuals identified as sharing risk haplotypes to search for rare risk variants in coding regions. We identified 45 rare haplotypes (>1 cM) that were significantly more common in cases than controls. By exome sequencing 105 haplotype carriers, we investigated these haplotypes for functional coding variants that could be tested for association in independent GWAS samples. We identified one rare missense variant in PCNTbut did not find statistical support for an association with schizophrenia in a replication analysis. However, IBD mapping can prioritize both individual samples and genomic regions for follow‐up analysis but genome rather than exome sequencing may be more effective at detecting risk variants on rare haplotypes.
Published: 2019
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229. Psychiatric and neurological disorders in late adolescence and risk of convictions for violent crime in men

Author: Moberg, Tomas, primary, Stenbacka, Marlene, additional, Tengström, Anders, additional, Jönsson, Erik G., additional, Nordström, Peter, additional, and Jokinen, Jussi, additional
Published: 2015
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230. First- and second-generation antipsychotic drug treatment and subcortical brain morphology in schizophrenia

Author: Jørgensen, Kjetil N., primary, Nesvåg, Ragnar, additional, Gunleiksrud, Sindre, additional, Raballo, Andrea, additional, Jönsson, Erik G., additional, and Agartz, Ingrid, additional
Published: 2015
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231. Cerebrospinal fluid monoamine metabolite concentrations as intermediate phenotypes between glutamate-related genes and psychosis

Author: Andreou, Dimitrios, primary, Söderman, Erik, additional, Axelsson, Tomas, additional, Sedvall, Göran C., additional, Terenius, Lars, additional, Agartz, Ingrid, additional, and Jönsson, Erik G., additional
Published: 2015
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232. Quantitative Analysis of 18F-(E)-N-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4′-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease

Author: Fazio, Patrik, primary, Svenningsson, Per, additional, Forsberg, Anton, additional, Jönsson, Erik G., additional, Amini, Nahid, additional, Nakao, Ryuji, additional, Nag, Sangram, additional, Halldin, Christer, additional, Farde, Lars, additional, and Varrone, Andrea, additional
Published: 2015
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233. Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

Author: Andreou, Dimitrios, Söderman, Erik, Axelsson, Tomas, Sedvall, Göran C, Terenius, Lars, Agartz, Ingrid, Jönsson, Erik G, Andreou, Dimitrios, Söderman, Erik, Axelsson, Tomas, Sedvall, Göran C, Terenius, Lars, Agartz, Ingrid, and Jönsson, Erik G
Abstract: BACKGROUND: Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are the major monoamine metabolites in the central nervous system (CNS). Their cerebrospinal fluid (CSF) concentrations, reflecting the monoamine turnover rates in CNS, are partially under genetic influence and have been associated with schizophrenia. We have hypothesized that CSF monoamine metabolite concentrations represent intermediate steps between single nucleotide polymorphisms (SNPs) in genes implicated in monoaminergic pathways and psychosis. METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. RESULTS: There were 42 nominally significant associations between SNPs and CSF monoamine metabolite concentrations, which exceeded the expected number (20) of nominal associations given the total number of tests performed. The strongest association (p = 0.0004) was found between MAOB rs5905512, a SNP previously reported to be associated with schizophrenia in men, and MHPG concentrations in men with psychotic disorder. Further analyses in 111 healthy individuals revealed that 41 of the 42 nominal associations were restricted to patients with psychosis and were absent in healthy controls. CONCLUSIONS: The present study suggests that altered monoamine turnover rates in CNS reflect intermediate steps in the associations between SNPs and psychosis.
Published: 2014
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234. Risk factors for adult interpersonal violence in suicide attempters

Author: Moberg, Tomas, Stenbacka, Marlene, Jönsson, Erik G, Nordström, Peter, Asberg, Marie, Jokinen, Jussi, Moberg, Tomas, Stenbacka, Marlene, Jönsson, Erik G, Nordström, Peter, Asberg, Marie, and Jokinen, Jussi
Abstract: BACKGROUND: Suicidal and violent behaviours are interlinked and share common biological underpinnings. In the present study we analysed the association between violent behaviour as a child, childhood trauma, adult psychiatric illness, and substance abuse in relation to interpersonal violence as an adult in suicide attempters with mood disorders. METHODS: A total of 161 suicide attempters were diagnosed with Structured Clinical Interviews and assessed with the Karolinska Interpersonal Violence Scale (KIVS) measuring exposure to violence and expressed violent behaviour in childhood (between 6-14 years of age) and during adult life (15 years or older). Ninety five healthy volunteers were used as a comparison group. A logistic regression analysis was conducted with the two KIVS subscales, expressed violent behaviour as a child and exposure to violence in childhood together with substance abuse, personality disorder diagnoses and age as possible predictors of adult interpersonal violence in suicide attempters. RESULTS: Violent behaviour as a child, age and substance abuse were significant predictors of adult interpersonal violence. ROC analysis for the prediction model for adult violence with the KIVS subscale expressed violence as a child gave an AUC of 0.79. Using two predictors: violent behaviour as a child and substance abuse diagnosis gave an AUC of 0.84. The optimal cut-off for the KIVS subscale expressed violence as a child was higher for male suicide attempters. CONCLUSIONS: Violent behaviour in childhood and substance abuse are important risk factors for adult interpersonal violent behaviour in suicide attempters.
Published: 2014
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235. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Author: Thompson, Paul M., Stein, Jason L., Medland, Sarah E., Hibar, Derrek P., Vasquez, Alejandro Arias, Renteria, Miguel E., Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J., Martin, Nicholas G., Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C., Andreassen, Ole A., Apostolova, Liana G., Appel, Katja, Armstrong, Nicola J., Aribisala, Benjamin, Bastin, Mark E., Bauer, Michael, Bearden, Carrie E., Bergmann, Ørjan, Binder, Elisabeth B., Blangero, John, Bockholt, Henry J., Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I., Booth, Tom, Bowman, Ian J., Bralten, Janita, Brouwer, Rachel M., Brunner, Han G., Brohawn, David G., Buckner, Randy L., Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R., Calhoun, Vince D., Cannon, Dara M., Cantor, Rita M., Carless, Melanie A., Caseras, Xavier, Cavalleri, Gianpiero L., Chakravarty, M. Mallar, Chang, Kiki D., Ching, Christopher R. K., Christoforou, Andrea, Cichon, Sven, Clark, Vincent P., Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Deary, Ian J., de Geus, Eco J. C., den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I., Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana, Fox, Peter T., Francks, Clyde, Frangou, Sophia, Frey, Eva Maria, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C., Godlewska, Beata, Goldstein, Rita Z., Gollub, Randy L., Grabe, Hans J., Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E., Gur, Ruben C., Göring, Harald H. H., Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B., Hall, Jeremy, Hardy, John, Hartman, Catharina A., Hass, Johanna, Hatton, Sean N., Haukvik, Unn K., Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B., Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J., Hollinshead, Marisa, Holmes, Avram J., Homuth, Georg, Hoogman, Martine, Hong, L. Elliot, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Hwang, Kristy S., Jack, Clifford R., Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G., Kahn, René S., Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B. J., Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A., Lauriello, John, Lawrie, Stephen M., Lee, Phil H., Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D., Li, Chiang-shan, Liberg, Benny, Liewald, David C., Liu, Xinmin, Lopez, Lorna M., Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W. J., MacQueen, Glenda M., Malt, Ulrik F., Mandl, René, Manoach, Dara S., Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Moses, Eric K., Mueller, Bryon A., Muñoz Maniega, Susana, Mühleisen, Thomas W., Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E., Nilsson, Lars-Göran, Nugent, Allison C., Nyberg, Lars, Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D., Penninx, Brenda W., Peterson, Charles P., Pfennig, Andrea, Phillips, Mary, Pike, G. Bruce, Poline, Jean-Baptiste, Potkin, Steven G., Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L., Roffman, Joshua L., Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J., Royle, Natalie A., Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S., Salami, Alireza, Satterthwaite, Theodore D., Savitz, Jonathan, Saykin, Andrew J., Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G., Schork, Andrew J., Schulz, S. Charles, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M., Simmons, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soares, Jair C., Sponheim, Scott R., Sprooten, Emma, Starr, John M., Steen, Vidar M., Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G., Teumer, Alexander, Toga, Arthur W., Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J., van Eijk, Kristel, van Erp, Theo G. M., van Haren, Neeltje E. M., van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C., Veltman, Dick J., Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M., Weale, Michael E., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Whalley, Heather C., Whelan, Christopher D., White, Tonya, Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P., Thalamuthu, Anbupalam, Schofield, Peter R., Freimer, Nelson B., Lawrence, Natalia S., Drevets, Wayne, Thompson, Paul M., Stein, Jason L., Medland, Sarah E., Hibar, Derrek P., Vasquez, Alejandro Arias, Renteria, Miguel E., Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J., Martin, Nicholas G., Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C., Andreassen, Ole A., Apostolova, Liana G., Appel, Katja, Armstrong, Nicola J., Aribisala, Benjamin, Bastin, Mark E., Bauer, Michael, Bearden, Carrie E., Bergmann, Ørjan, Binder, Elisabeth B., Blangero, John, Bockholt, Henry J., Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I., Booth, Tom, Bowman, Ian J., Bralten, Janita, Brouwer, Rachel M., Brunner, Han G., Brohawn, David G., Buckner, Randy L., Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R., Calhoun, Vince D., Cannon, Dara M., Cantor, Rita M., Carless, Melanie A., Caseras, Xavier, Cavalleri, Gianpiero L., Chakravarty, M. Mallar, Chang, Kiki D., Ching, Christopher R. K., Christoforou, Andrea, Cichon, Sven, Clark, Vincent P., Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Deary, Ian J., de Geus, Eco J. C., den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I., Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana, Fox, Peter T., Francks, Clyde, Frangou, Sophia, Frey, Eva Maria, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C., Godlewska, Beata, Goldstein, Rita Z., Gollub, Randy L., Grabe, Hans J., Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E., Gur, Ruben C., Göring, Harald H. H., Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B., Hall, Jeremy, Hardy, John, Hartman, Catharina A., Hass, Johanna, Hatton, Sean N., Haukvik, Unn K., Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B., Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J., Hollinshead, Marisa, Holmes, Avram J., Homuth, Georg, Hoogman, Martine, Hong, L. Elliot, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Hwang, Kristy S., Jack, Clifford R., Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G., Kahn, René S., Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B. J., Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A., Lauriello, John, Lawrie, Stephen M., Lee, Phil H., Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D., Li, Chiang-shan, Liberg, Benny, Liewald, David C., Liu, Xinmin, Lopez, Lorna M., Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W. J., MacQueen, Glenda M., Malt, Ulrik F., Mandl, René, Manoach, Dara S., Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Moses, Eric K., Mueller, Bryon A., Muñoz Maniega, Susana, Mühleisen, Thomas W., Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E., Nilsson, Lars-Göran, Nugent, Allison C., Nyberg, Lars, Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D., Penninx, Brenda W., Peterson, Charles P., Pfennig, Andrea, Phillips, Mary, Pike, G. Bruce, Poline, Jean-Baptiste, Potkin, Steven G., Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L., Roffman, Joshua L., Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J., Royle, Natalie A., Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S., Salami, Alireza, Satterthwaite, Theodore D., Savitz, Jonathan, Saykin, Andrew J., Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G., Schork, Andrew J., Schulz, S. Charles, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M., Simmons, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soares, Jair C., Sponheim, Scott R., Sprooten, Emma, Starr, John M., Steen, Vidar M., Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G., Teumer, Alexander, Toga, Arthur W., Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J., van Eijk, Kristel, van Erp, Theo G. M., van Haren, Neeltje E. M., van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C., Veltman, Dick J., Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M., Weale, Michael E., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Whalley, Heather C., Whelan, Christopher D., White, Tonya, Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P., Thalamuthu, Anbupalam, Schofield, Peter R., Freimer, Nelson B., Lawrence, Natalia S., and Drevets, Wayne
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
Published: 2014

236. Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: An association study

Author: Holtze, Maria, Saetre, Peter, Erhardt, Sophie, Schwieler, Lilly, Werge, Thomas, Hansen, Thomas, Nielsen, Jimmi, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A., Hall, Håkan, Terenius, Lars, Agartz, Ingrid, Engberg, Göran, Jönsson, Erik G., and Schalling, Martin
Published: 2011
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237. Dystrobrevin-binding protein 1 gene ( DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers

Author: Andreou, Dimitrios, Saetre, Peter, Kähler, Anna K., Werge, Thomas, Andreassen, Ole A., Agartz, Ingrid, Sedvall, Göran C., Hall, Håkan, Terenius, Lars, and Jönsson, Erik G.
Published: 2011
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238. Consistent Functional Connectivity Alterations in Schizophrenia Spectrum Disorder: A Multisite Study.

Author: Skåtun, Kristina C., Kaufmann, Tobias, Nhat Trung Doan, Alnæs, Dag, Córdova-Palomera, Aldo, Jönsson, Erik G., Fatouros-Bergman, Helena, Flyckt, Lena, Melle, Ingrid, Andreassen, Ole A., Agartz, Ingrid, and Westlye, Lars T.
Subjects: BRAIN, MAGNETIC resonance imaging, MEDICAL cooperation, MULTIVARIATE analysis, RESEARCH, SCHIZOPHRENIA, STATISTICS
Abstract: Schizophrenia (SZ) is a severe mental illness with high heritability and complex etiology. Mounting evidence from neuroimaging has implicated disrupted brain network connectivity in the pathophysiology. However, previous findings are inconsistent, likely due to a combination of methodological and clinical variability and relatively small sample sizes. Few studies have used a data-driven approach for characterizing pathological interactions between regions in the whole brain and evaluated the generalizability across independent samples. To overcome this issue, we collected resting-state functional magnetic resonance imaging data from 3 independent samples (1 from Norway and 2 from Sweden) consisting of 182 persons with a SZ spectrum diagnosis and 348 healthy controls. We used a whole-brain data-driven definition of network nodes and regularized partial correlations to evaluate and compare putatively direct brain network node interactions between groups. The clinical utility of the functional connectivity features and the generalizability of effects across samples were evaluated by training and testing multivariate classifiers in the independent samples using machine learning. Univariate analyses revealed 14 network edges with consistent reductions in functional connectivity encompassing frontal, somatomotor, visual, auditory, and subcortical brain nodes in patients with SZ. We found a high overall accuracy in classifying patients and controls (up to 80%) using independent training and test samples, strongly supporting the generalizability of connectivity alterations across different scanners and heterogeneous samples. Overall, our findings demonstrate robust reductions in functional connectivity in SZ spectrum disorders, indicating disrupted information flow in sensory, subcortical, and frontal brain regions. [ABSTRACT FROM AUTHOR]
Published: 2017
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239. Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases

Author: Gusev, Alexander, primary, Lee, S. Hong, additional, Trynka, Gosia, additional, Finucane, Hilary, additional, Vilhjálmsson, Bjarni J., additional, Xu, Han, additional, Zang, Chongzhi, additional, Ripke, Stephan, additional, Bulik-Sullivan, Brendan, additional, Stahl, Eli, additional, Kähler, Anna K., additional, Hultman, Christina M., additional, Purcell, Shaun M., additional, McCarroll, Steven A., additional, Daly, Mark, additional, Pasaniuc, Bogdan, additional, Sullivan, Patrick F., additional, Neale, Benjamin M., additional, Wray, Naomi R., additional, Raychaudhuri, Soumya, additional, Price, Alkes L., additional, Neale, Benjamin M., additional, Corvin, Aiden, additional, Walters, James T.R., additional, Farh, Kai-How, additional, Holmans, Peter A., additional, Lee, Phil, additional, Collier, David A., additional, Huang, Hailiang, additional, Pers, Tune H., additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Albus, Margot, additional, Alexander, Madeline, additional, Amin, Farooq, additional, Bacanu, Silviu A., additional, Begemann, Martin, additional, Belliveau, Richard A., additional, Bene, Judit, additional, Bergen, Sarah E., additional, Bevilacqua, Elizabeth, additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Børglum, Anders D., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Catts, Stanley V., additional, Chambert, Kimberly D., additional, Chan, Raymond C.K., additional, Chen, Ronald Y.L., additional, Chen, Eric Y.H., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Cormican, Paul, additional, Craddock, Nick, additional, Crowley, James J., additional, Curtis, David, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, Degenhardt, Franziska, additional, Del Favero, Jurgen, additional, DeLisi, Lynn E., additional, Demontis, Ditte, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Djurovic, Srdjan, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Durmishi, Naser, additional, Eichhammer, Peter, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Essioux, Laurent, additional, Fanous, Ayman H., additional, Farrell, Martilias S., additional, Frank, Josef, additional, Franke, Lude, additional, Freedman, Robert, additional, Freimer, Nelson B., additional, Friedl, Marion, additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Gershon, Elliot S., additional, Giegling, Ina, additional, Giusti-Rodrguez, Paola, additional, Godard, Stephanie, additional, Goldstein, Jacqueline I., additional, Golimbet, Vera, additional, Gopal, Srihari, additional, Gratten, Jacob, additional, Grove, Jakob, additional, de Haan, Lieuwe, additional, Hammer, Christian, additional, Hamshere, Marian L., additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Hartmann, Annette M., additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hofman, Andrea, additional, Hollegaard, Mads V., additional, Hougaard, David M., additional, Ikeda, Masashi, additional, Joa, Inge, additional, Julià, Antonio, additional, Kahn, René S., additional, Kalaydjieva, Luba, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kelly, Brian J., additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Klovins, Janis, additional, Knowles, James A., additional, Konte, Bettina, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kuzelova-Ptackova, Hana, additional, Kähler, Anna K., additional, Laurent, Claudine, additional, Keong, Jimmy Lee Chee, additional, Legge, Sophie E., additional, Lerer, Bernard, additional, Li, Miaoxin, additional, Li, Tao, additional, Liang, Kung-Yee, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lnnqvist, Jouko, additional, Macek, Milan, additional, Magnusson, Patrik K.E., additional, Maher, Brion S., additional, Maier, Wolfgang, additional, Mallet, Jacques, additional, Marsal, Sara, additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, McCarley, Robert W., additional, McDonald, Colm, additional, McIntosh, Andrew M., additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Melle, Ingrid, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milani, Lili, additional, Milanova, Vihra, additional, Mokrab, Younes, additional, Morris, Derek W., additional, Mors, Ole, additional, Mortensen, Preben B., additional, Murphy, Kieran C., additional, Murray, Robin M., additional, Myin-Germeys, Inez, additional, Mller-Myhsok, Bertram, additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nikitina-Zake, Liene, additional, Nisenbaum, Laura, additional, Nordin, Annelie, additional, O’Callaghan, Eadbhard, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Van Os, Jim, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Papiol, Sergi, additional, Parkhomenko, Elena, additional, Pato, Michele T., additional, Paunio, Tiina, additional, Pejovic-Milovancevic, Milica, additional, Perkins, Diana O., additional, Pietilinen, Olli, additional, Pimm, Jonathan, additional, Pocklington, Andrew J., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Rasmussen, Henrik B., additional, Reichenberg, Abraham, additional, Reimers, Mark A., additional, Richards, Alexander L., additional, Roffman, Joshua L., additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Salomaa, Veikko, additional, Sanders, Alan R., additional, Schall, Ulrich, additional, Schubert, Christian R., additional, Schulze, Thomas G., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Shi, Jianxin, additional, Sigurdsson, Engilbert, additional, Silagadze, Teimuraz, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slominsky, Petr, additional, Smoller, Jordan W., additional, So, Hon-Cheong, additional, Spencer, Chris C.A., additional, Stahl, Eli A., additional, Stefansson, Hreinn, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Straub, Richard E., additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Sderman, Erik, additional, Thirumalai, Srinivas, additional, Toncheva, Draga, additional, Tooney, Paul A., additional, Tosato, Sarah, additional, Veijola, Juha, additional, Waddington, John, additional, Walsh, Dermot, additional, Wang, Dai, additional, Wang, Qiang, additional, Webb, Bradley T., additional, Weiser, Mark, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wormley, Brandon K., additional, Wu, Jing Qin, additional, Xi, Hualin Simon, additional, Zai, Clement C., additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Wray, Naomi R., additional, Stefansson, Kari, additional, Visscher, Peter M., additional, Adolfsson, Rolf, additional, Andreassen, Ole A., additional, Blackwood, Douglas H.R., additional, Bramon, Elvira, additional, Buxbaum, Joseph D., additional, Brglum, Anders D., additional, Cichon, Sven, additional, Darvasi, Ariel, additional, Domenici, Enrico, additional, Ehrenreich, Hannelore, additional, Esko, Tõnu, additional, Gejman, Pablo V., additional, Gill, Michael, additional, Gurling, Hugh, additional, Hultman, Christina M., additional, Iwata, Nakao, additional, Jablensky, Assen V., additional, Jönsson, Erik G., additional, Kendler, Kenneth S., additional, Kirov, George, additional, Knight, Jo, additional, Lencz, Todd, additional, Levinson, Douglas F., additional, Li, Qingqin S., additional, Liu, Jianjun, additional, Malhotra, Anil K., additional, McCarroll, Steven A., additional, McQuillin, Andrew, additional, Moran, Jennifer L., additional, Mowry, Bryan J., additional, Nthen, Markus M., additional, Ophoff, Roel A., additional, Owen, Michael J., additional, Palotie, Aarno, additional, Pato, Carlos N., additional, Petryshen, Tracey L., additional, Posthuma, Danielle, additional, Rietschel, Marcella, additional, Riley, Brien P., additional, Rujescu, Dan, additional, Sham, Pak C., additional, Sklar, Pamela, additional, St. Clair, David, additional, Weinberger, Daniel R., additional, Wendland, Jens R., additional, Werge, Thomas, additional, Daly, Mark J., additional, Sullivan, Patrick F., additional, O’Donovan, Michael C., additional, Chambert, Kimberly, additional, Moran, Jennifer L., additional, Akterin, Susanne, additional, Bergen, Sarah, additional, Magnusson, Patrik K.E., additional, Ruderfer, Douglas, additional, Scolnick, Edward, additional, Purcell, Shaun, additional, and McCarroll, Steve, additional
Published: 2014
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240. Risk factors for adult interpersonal violence in suicide attempters

Author: Moberg, Tomas, primary, Stenbacka, Marlene, additional, Jönsson, Erik G, additional, Nordström, Peter, additional, Åsberg, Marie, additional, and Jokinen, Jussi, additional
Published: 2014
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241. Reduced brain cortical folding in schizophrenia revealed in two independent samples

Author: Nesvåg, Ragnar, primary, Schaer, Marie, additional, Haukvik, Unn K., additional, Westlye, Lars T., additional, Rimol, Lars M., additional, Lange, Elisabeth H., additional, Hartberg, Cecilie B., additional, Ottet, Marie-Christine, additional, Melle, Ingrid, additional, Andreassen, Ole A., additional, Jönsson, Erik G., additional, Agartz, Ingrid, additional, and Eliez, Stephan, additional
Published: 2014
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242. Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

Author: Andreou, Dimitrios, primary, Söderman, Erik, additional, Axelsson, Tomas, additional, Sedvall, Göran C, additional, Terenius, Lars, additional, Agartz, Ingrid, additional, and Jönsson, Erik G, additional
Published: 2014
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243. No association between a putative functional promoter variant in the dopamine β-hydroxylase gene and schizophrenia

Author: Jönsson, Erik G., Jamra, Rami Abou, Schumacher, Johannes, Flyckt, Lena, Edman, Gunnar, Forslund, Kaj, Mattila-Evenden, Marja, Rylander, Gunnar, Åsberg, Marie, Bjerkenstedt, Lars, Wiesel, Frits-Axel, Propping, Peter, Cichon, Sven, Nöthen, Markus, and Sedvall, Göran C.
Published: 2003

244. Medication and suicide risk in schizophrenia : A nested case-control study

Author: Reutfors, Johan, Bahmanyar, Shahram, Jönsson, Erik G, Brandt, Lena, Bodén, Robert, Ekbom, Anders, Ösby, Urban, Reutfors, Johan, Bahmanyar, Shahram, Jönsson, Erik G, Brandt, Lena, Bodén, Robert, Ekbom, Anders, and Ösby, Urban
Abstract: INTRODUCTION: Patients with schizophrenia are at increased risk of suicide, but data from controlled studies of pharmacotherapy in relation to suicide risk is limited. AIM: To explore suicide risk in schizophrenia in relation to medication with antipsychotics, antidepressants, and lithium. METHODS: Of all patients with a first clinical discharge diagnosis of schizophrenia or schizoaffective disorder in Stockholm County between 1984 and 2000 (n=4000), patients who died by suicide within five years from diagnosis were defined as cases (n=84; 54% male). Individually matched controls were identified from the same population. Information on prescribed medication was retrieved from psychiatric records in a blinded way. Adjusted odds ratios [OR] of the association between medication and suicide were calculated by conditional logistic regression. RESULTS: Lower suicide risk was found in patients who had been prescribed a second generation antipsychotic (clozapine, olanzapine, risperidone, or ziprasidone; 12 cases and 20 controls): OR 0.29 (95% confidence interval [CI], 0.09-0.97). When the 6 cases and 8 controls who had been prescribed clozapine were excluded, the OR was 0.23 (95% CI 0.06-0.89). No significant association was observed between suicide and prescription of any antipsychotic, depot injection antipsychotics, antidepressants, SSRI, or lithium. CONCLUSIONS: Lower suicide risk for patients who had been prescribed second generation antipsychotics may be related to a pharmacological effect of these drugs, to differences in adherence, or to differences in other patient characteristics associated with lower suicide risk.
Published: 2013
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245. No association between a promoter dopamine <tex>D_{4}$</tex> receptor gene variant and schizophrenia

Author: Jönsson, Erik G., Ivo, Roland, Forslund, Kaj, Mattila-Evenden, Marja, Rylander, Gunnar, Cichon, Sven, Propping, Peter, Nöthen, Markus, Asberg, Marie, and Sedvall, Göran C.
Published: 2001

246. Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia

Author: Lindholm Carlstrom, Eva, Saetre, Peter, Rosengren, Anders, Thygesen, Johan H, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A, Werge, Thomas, Agartz, Ingrid, Hall, Håkan, Terenius, Lars, Jönsson, Erik G, Lindholm Carlstrom, Eva, Saetre, Peter, Rosengren, Anders, Thygesen, Johan H, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A, Werge, Thomas, Agartz, Ingrid, Hall, Håkan, Terenius, Lars, and Jönsson, Erik G
Abstract: BACKGROUND: The serotonin (5-hydroxytryptamin; 5-HT) system has a central role in the circuitry of cognition and emotions. Multiple lines of evidence suggest that genetic variation in the serotonin transporter gene (SLC6A4; 5-HTT) is associated with schizophrenia and suicidal behavior. In this study, we wanted to elucidate whether SLC6A4 variations is involved in attempted suicide among patients with schizophrenia in a Scandinavian case-control sample. METHODS: Patients diagnosed with schizophrenia from three Scandinavian samples were assessed for presence or absence of suicide attempts, based on record reviews and interview data. Seven SLC6A4 single nucleotide polymorphisms (SNPs) were genotyped in 837 schizophrenia patients and 1,473 control individuals. Association analyses and statistical evaluations were performed with the program UNPHASED (version 3.0.9). RESULTS: We observed an allele association between the SNP rs16965628, located in intron one of SLC6A4, and attempted suicide (adjusted P-value = 0.04), among patients with schizophrenia. No association was found to a diagnosis of schizophrenia, when patients were compared to healthy control individuals. CONCLUSION: The gene SLC6A4 appears to be involved in suicidal ideation among patients with schizophrenia. Independent replication is needed before more firm conclusions can be drawn.
Published: 2012

247. Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder

Author: Vassos, Evangelos, Steinberg, Stacy, Cichon, Sven, Breen, Gerome, Sigurdsson, Engilbert, Andreassen, Ole A, Djurovic, Srdjan, Morken, Gunnar, Grigoroiu-Serbanescu, Maria, Diaconu, Carmen C, Czerski, Piotr M, Hauser, Joanna, Babadjanova, Gulja, Abramova, Lilia I, Mühleisen, Thomas W, Nöthen, Markus M, Rietschel, Marcella, McGuffin, Peter, St Clair, David, Gustafsson, Omar, Melle, Ingrid, Pietiläinen, Olli P H, Ruggeri, Mirella, Tosato, Sarah, Werge, Thomas, Ophoff, Roel A, Rujescu, Dan, Børglum, Anders, Mors, Ole, Mortensen, Preben Bo, Demontis, Ditte, Hollegaard, Mads Vilhelm, van Winkel, Ruud, Kenis, Gunter, De Hert, Marc, Réthelyi, János M, Bitter, István, Rubino, I Alex, Golimbet, Vera, Kiemeney, Lambertus A, van den Berg, Leonard H, Franke, Barbara, Jönsson, Erik G, Farmer, Anne, Stefansson, Hreinn, Stefansson, Kari, Collier, David A, Vassos, Evangelos, Steinberg, Stacy, Cichon, Sven, Breen, Gerome, Sigurdsson, Engilbert, Andreassen, Ole A, Djurovic, Srdjan, Morken, Gunnar, Grigoroiu-Serbanescu, Maria, Diaconu, Carmen C, Czerski, Piotr M, Hauser, Joanna, Babadjanova, Gulja, Abramova, Lilia I, Mühleisen, Thomas W, Nöthen, Markus M, Rietschel, Marcella, McGuffin, Peter, St Clair, David, Gustafsson, Omar, Melle, Ingrid, Pietiläinen, Olli P H, Ruggeri, Mirella, Tosato, Sarah, Werge, Thomas, Ophoff, Roel A, Rujescu, Dan, Børglum, Anders, Mors, Ole, Mortensen, Preben Bo, Demontis, Ditte, Hollegaard, Mads Vilhelm, van Winkel, Ruud, Kenis, Gunter, De Hert, Marc, Réthelyi, János M, Bitter, István, Rubino, I Alex, Golimbet, Vera, Kiemeney, Lambertus A, van den Berg, Leonard H, Franke, Barbara, Jönsson, Erik G, Farmer, Anne, Stefansson, Hreinn, Stefansson, Kari, and Collier, David A
Abstract: Common genetic polymorphisms at chromosome 3p21.1, including rs2251219 in polybromo 1 (PBRM1), have been implicated in susceptibility to bipolar affective disorder (BP) through genome-wide association studies. Subsequent studies have suggested that this is also a risk locus for other psychiatric phenotypes, including major depression and schizophrenia.
Published: 2012

248. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia:No consistent evidence for an association in the nordic population

Author: Saetre, Peter, Grove, Jakob, Børglum, Anders, Mors, Ole, Werge, Thomas, Andreassen, Ole A, Vares, Maria, Agartz, Ingrid, Terenius, Lars, Jönsson, Erik G, Saetre, Peter, Grove, Jakob, Børglum, Anders, Mors, Ole, Werge, Thomas, Andreassen, Ole A, Vares, Maria, Agartz, Ingrid, Terenius, Lars, and Jönsson, Erik G
Abstract: Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in metabolic pathways of importance for nucleotide synthesis and methylation of DNA, membranes, proteins and lipids. The MTHFR gene includes a common polymorphism (rs1801133 or C677T), which is associated with enzyme activity. The T-allele of the C677T polymorphism has been associated with earlier age at onset of schizophrenia in a Scandinavian population, although no association was found in replication attempts in other populations. Extending the study to five Nordic samples consisting of 2,198 patients with schizophrenia, including the original Scandinavian samples, there was no significant association between MTHFR C677T polymorphism and age at onset in schizophrenia. The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population. © 2012 Wiley Periodicals, Inc.
Published: 2012

249. Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia

Author: Jönsson, Erik G, Saetre, Peter, Nyholm, Helena, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A, Skjødt, Celina, Thygesen, Johan H, Werge, Thomas, Hall, Håkan, Agartz, Ingrid, Terenius, Lars, Jönsson, Erik G, Saetre, Peter, Nyholm, Helena, Djurovic, Srdjan, Melle, Ingrid, Andreassen, Ole A, Skjødt, Celina, Thygesen, Johan H, Werge, Thomas, Hall, Håkan, Agartz, Ingrid, and Terenius, Lars
Published: 2012

250. Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)

Author: Djurovic, Srdjan, Le Hellard, Stephanie, Kähler, Anna K., Jönsson, Erik G., Agartz, Ingrid, Steen, Vidar M., Hall, Håkan, Wang, August G., Rasmussen, Henrik B., Melle, Ingrid, Werge, Thomas, and Andreassen, Ole A.
Published: 2009
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